Simultaneous blockade of dopamine and noradrenaline reuptake promotes disadvantageous decision making in a rat gambling task
Identifieur interne : 000793 ( Pmc/Corpus ); précédent : 000792; suivant : 000794Simultaneous blockade of dopamine and noradrenaline reuptake promotes disadvantageous decision making in a rat gambling task
Auteurs : Petra J. J. Baarendse ; Catharine A. Winstanley ; Louk J. M. J. VanderschurenSource :
- Psychopharmacology [ 0033-3158 ] ; 2012.
Abstract
The inability to make profitable long-term decisions has been implicated in several psychiatric disorders. There is emerging evidence to support a role for dopamine (DA) in decision making, but our understanding of the role of noradrenaline (NA) and serotonin (5-HT) in decision making, and of possible interactions between the three monoamines, is limited. Moreover, impulsivity has been associated with aberrant decision making, but the underlying mechanisms are incompletely understood.
To improve our understanding of the neuropharmacological mechanisms of decision making and impulse control.
We investigated the effects of amphetamine (0.25-1.0 mg/kg), and selective reuptake inhibitors of DA (GBR12909; 2.5-10 mg/kg), NA (atomoxetine; 0.3-3.0 mg/kg) and 5-HT (citalopram; 0.3-3.0 mg/kg) in a rat gambling task (rGT). Since the rGT allows for detection of impulsive action, i.e., premature responding, we also assessed the relationship between decision making and impulsivity.
In the rGT, rats developed an optimal choice strategy from the first session onwards. Elevation of endogenous DA or NA levels increased and decreased impulsivity, respectively, but did not alter decision making. However, simultaneous blockade of DA and NA disrupted decision making, reflected by a relative decrease in choice for the advantageous choice options. Increasing 5-HT neurotransmission did not affect decision making or impulsivity.
These data suggest important, but complementary or redundant roles of DA and NA neurotransmission in decision making processes based on reward probability and punishment. Moreover, impulse control and decision making in the rGT rely on dissociable mechanisms.
Url:
DOI: 10.1007/s00213-012-2857-z
PubMed: 22968659
PubMed Central: 3531574
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PMC:3531574Le document en format XML
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<author><name sortKey="Baarendse, Petra J J" sort="Baarendse, Petra J J" uniqKey="Baarendse P" first="Petra J. J." last="Baarendse">Petra J. J. Baarendse</name>
<affiliation><nlm:aff id="A1">Dept. of Neuroscience and Pharmacology, Rudolf Magnus Institute of Neuroscience, UMC Utrecht, Utrecht, The Netherlands</nlm:aff>
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<author><name sortKey="Winstanley, Catharine A" sort="Winstanley, Catharine A" uniqKey="Winstanley C" first="Catharine A." last="Winstanley">Catharine A. Winstanley</name>
<affiliation><nlm:aff id="A3">Department of Psychology, University of British Columbia, Vancouver, British Columbia V6T 1Z4, Canada</nlm:aff>
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<author><name sortKey="Vanderschuren, Louk J M J" sort="Vanderschuren, Louk J M J" uniqKey="Vanderschuren L" first="Louk J. M. J." last="Vanderschuren">Louk J. M. J. Vanderschuren</name>
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<affiliation><nlm:aff id="A2">Dept. of Animals in Science and Society, Division of Behavioural Neuroscience, Faculty of Veterinary Medicine, Utrecht University, Utrecht, The Netherlands</nlm:aff>
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<author><name sortKey="Winstanley, Catharine A" sort="Winstanley, Catharine A" uniqKey="Winstanley C" first="Catharine A." last="Winstanley">Catharine A. Winstanley</name>
<affiliation><nlm:aff id="A3">Department of Psychology, University of British Columbia, Vancouver, British Columbia V6T 1Z4, Canada</nlm:aff>
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<author><name sortKey="Vanderschuren, Louk J M J" sort="Vanderschuren, Louk J M J" uniqKey="Vanderschuren L" first="Louk J. M. J." last="Vanderschuren">Louk J. M. J. Vanderschuren</name>
<affiliation><nlm:aff id="A1">Dept. of Neuroscience and Pharmacology, Rudolf Magnus Institute of Neuroscience, UMC Utrecht, Utrecht, The Netherlands</nlm:aff>
</affiliation>
<affiliation><nlm:aff id="A2">Dept. of Animals in Science and Society, Division of Behavioural Neuroscience, Faculty of Veterinary Medicine, Utrecht University, Utrecht, The Netherlands</nlm:aff>
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<series><title level="j">Psychopharmacology</title>
<idno type="ISSN">0033-3158</idno>
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<front><div type="abstract" xml:lang="en"><sec id="S1"><title>Rationale</title>
<p id="P1">The inability to make profitable long-term decisions has been implicated in several psychiatric disorders. There is emerging evidence to support a role for dopamine (DA) in decision making, but our understanding of the role of noradrenaline (NA) and serotonin (5-HT) in decision making, and of possible interactions between the three monoamines, is limited. Moreover, impulsivity has been associated with aberrant decision making, but the underlying mechanisms are incompletely understood.</p>
</sec>
<sec id="S2"><title>Objective</title>
<p id="P2">To improve our understanding of the neuropharmacological mechanisms of decision making and impulse control.</p>
</sec>
<sec id="S3"><title>Methods</title>
<p id="P3">We investigated the effects of amphetamine (0.25-1.0 mg/kg), and selective reuptake inhibitors of DA (GBR12909; 2.5-10 mg/kg), NA (atomoxetine; 0.3-3.0 mg/kg) and 5-HT (citalopram; 0.3-3.0 mg/kg) in a rat gambling task (rGT). Since the rGT allows for detection of impulsive action, i.e., premature responding, we also assessed the relationship between decision making and impulsivity.</p>
</sec>
<sec id="S4"><title>Results</title>
<p id="P4">In the rGT, rats developed an optimal choice strategy from the first session onwards. Elevation of endogenous DA or NA levels increased and decreased impulsivity, respectively, but did not alter decision making. However, simultaneous blockade of DA and NA disrupted decision making, reflected by a relative decrease in choice for the advantageous choice options. Increasing 5-HT neurotransmission did not affect decision making or impulsivity.</p>
</sec>
<sec id="S5"><title>Conclusions</title>
<p id="P5">These data suggest important, but complementary or redundant roles of DA and NA neurotransmission in decision making processes based on reward probability and punishment. Moreover, impulse control and decision making in the rGT rely on dissociable mechanisms.</p>
</sec>
</div>
</front>
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<pmc article-type="research-article"><pmc-comment>The publisher of this article does not allow downloading of the full text in XML form.</pmc-comment>
<pmc-dir>properties manuscript</pmc-dir>
<front><journal-meta><journal-id journal-id-type="nlm-journal-id">7608025</journal-id>
<journal-id journal-id-type="pubmed-jr-id">6790</journal-id>
<journal-id journal-id-type="nlm-ta">Psychopharmacology (Berl)</journal-id>
<journal-id journal-id-type="iso-abbrev">Psychopharmacology (Berl.)</journal-id>
<journal-title-group><journal-title>Psychopharmacology</journal-title>
</journal-title-group>
<issn pub-type="ppub">0033-3158</issn>
<issn pub-type="epub">1432-2072</issn>
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<article-meta><article-id pub-id-type="pmid">22968659</article-id>
<article-id pub-id-type="pmc">3531574</article-id>
<article-id pub-id-type="doi">10.1007/s00213-012-2857-z</article-id>
<article-id pub-id-type="manuscript">NIHMS407347</article-id>
<article-categories><subj-group subj-group-type="heading"><subject>Article</subject>
</subj-group>
</article-categories>
<title-group><article-title>Simultaneous blockade of dopamine and noradrenaline reuptake promotes disadvantageous decision making in a rat gambling task</article-title>
</title-group>
<contrib-group><contrib contrib-type="author"><name><surname>Baarendse</surname>
<given-names>Petra J.J.</given-names>
</name>
<xref ref-type="aff" rid="A1">1</xref>
</contrib>
<contrib contrib-type="author"><name><surname>Winstanley</surname>
<given-names>Catharine A.</given-names>
</name>
<xref ref-type="aff" rid="A3">3</xref>
</contrib>
<contrib contrib-type="author"><name><surname>Vanderschuren</surname>
<given-names>Louk J.M.J.</given-names>
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<xref ref-type="aff" rid="A1">1</xref>
<xref ref-type="aff" rid="A2">2</xref>
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<aff id="A1"><label>1</label>
Dept. of Neuroscience and Pharmacology, Rudolf Magnus Institute of Neuroscience, UMC Utrecht, Utrecht, The Netherlands</aff>
<aff id="A2"><label>2</label>
Dept. of Animals in Science and Society, Division of Behavioural Neuroscience, Faculty of Veterinary Medicine, Utrecht University, Utrecht, The Netherlands</aff>
<aff id="A3"><label>3</label>
Department of Psychology, University of British Columbia, Vancouver, British Columbia V6T 1Z4, Canada</aff>
<author-notes><corresp id="CR1">Corresponding author: Louk J.M.J. Vanderschuren, PhD, Rudolf Magnus Institute of Neuroscience, Dept. of Neuroscience and Pharmacology, University Medical Center Utrecht, Universiteitsweg 100, 3584 CG Utrecht, The Netherlands, tel: +31-88-7568811, fax: +31-88-7568155, <email>l.j.m.j.vanderschuren@umcutrecht.nl</email>
</corresp>
</author-notes>
<pub-date pub-type="nihms-submitted"><day>13</day>
<month>9</month>
<year>2012</year>
</pub-date>
<pub-date pub-type="epub"><day>12</day>
<month>9</month>
<year>2012</year>
</pub-date>
<pub-date pub-type="ppub"><month>2</month>
<year>2013</year>
</pub-date>
<pub-date pub-type="pmc-release"><day>01</day>
<month>2</month>
<year>2014</year>
</pub-date>
<volume>225</volume>
<issue>3</issue>
<fpage>719</fpage>
<lpage>731</lpage>
<abstract><sec id="S1"><title>Rationale</title>
<p id="P1">The inability to make profitable long-term decisions has been implicated in several psychiatric disorders. There is emerging evidence to support a role for dopamine (DA) in decision making, but our understanding of the role of noradrenaline (NA) and serotonin (5-HT) in decision making, and of possible interactions between the three monoamines, is limited. Moreover, impulsivity has been associated with aberrant decision making, but the underlying mechanisms are incompletely understood.</p>
</sec>
<sec id="S2"><title>Objective</title>
<p id="P2">To improve our understanding of the neuropharmacological mechanisms of decision making and impulse control.</p>
</sec>
<sec id="S3"><title>Methods</title>
<p id="P3">We investigated the effects of amphetamine (0.25-1.0 mg/kg), and selective reuptake inhibitors of DA (GBR12909; 2.5-10 mg/kg), NA (atomoxetine; 0.3-3.0 mg/kg) and 5-HT (citalopram; 0.3-3.0 mg/kg) in a rat gambling task (rGT). Since the rGT allows for detection of impulsive action, i.e., premature responding, we also assessed the relationship between decision making and impulsivity.</p>
</sec>
<sec id="S4"><title>Results</title>
<p id="P4">In the rGT, rats developed an optimal choice strategy from the first session onwards. Elevation of endogenous DA or NA levels increased and decreased impulsivity, respectively, but did not alter decision making. However, simultaneous blockade of DA and NA disrupted decision making, reflected by a relative decrease in choice for the advantageous choice options. Increasing 5-HT neurotransmission did not affect decision making or impulsivity.</p>
</sec>
<sec id="S5"><title>Conclusions</title>
<p id="P5">These data suggest important, but complementary or redundant roles of DA and NA neurotransmission in decision making processes based on reward probability and punishment. Moreover, impulse control and decision making in the rGT rely on dissociable mechanisms.</p>
</sec>
</abstract>
<kwd-group><kwd>Decision making</kwd>
<kwd>Impulsivity</kwd>
<kwd>Dopamine</kwd>
<kwd>Serotonin</kwd>
<kwd>Noradrenaline</kwd>
<kwd>Rat gambling task</kwd>
</kwd-group>
<funding-group><award-group><funding-source country="United States">National Institute on Drug Abuse : NIDA</funding-source>
<award-id>R01 DA022628 || DA</award-id>
</award-group>
</funding-group>
</article-meta>
</front>
</pmc>
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