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<record><TEI><teiHeader><fileDesc><titleStmt><title xml:lang="en">The Human Proteome Organization Chromosome 6 Consortium: Integrating chromosome-centric and biology/disease driven strategies</title><author><name sortKey="Borchers, C H" sort="Borchers, C H" uniqKey="Borchers C" first="C. H." last="Borchers">C. H. Borchers</name><affiliation><nlm:aff id="A1">University of Victoria/Genome BC Proteomics Centre, Victoria, BC, Canada</nlm:aff></affiliation></author><author><name sortKey="Kast, J" sort="Kast, J" uniqKey="Kast J" first="J." last="Kast">J. Kast</name><affiliation><nlm:aff id="A2">Biomedical Research Centre, University of British Columbia, Vancouver, BC, Canada</nlm:aff></affiliation></author><author><name sortKey="Foster, L J" sort="Foster, L J" uniqKey="Foster L" first="L. J." last="Foster">L. J. Foster</name><affiliation><nlm:aff id="A3">Centre for High Throughput Biology, University of British Columbia, BC, Canada</nlm:aff></affiliation></author><author><name sortKey="Siu, K W M" sort="Siu, K W M" uniqKey="Siu K" first="K. W. M." last="Siu">K. W. M. Siu</name><affiliation><nlm:aff id="A4">Centre for Research in Mass Spectrometry, York University, Ontario, Canada</nlm:aff></affiliation></author><author><name sortKey="Overall, C M" sort="Overall, C M" uniqKey="Overall C" first="C. M." last="Overall">C. M. Overall</name><affiliation><nlm:aff id="A5">Centre for Blood Research, Faculty of Dentistry, University of British Columbia, Canada</nlm:aff></affiliation></author><author><name sortKey="Binkowski, T A" sort="Binkowski, T A" uniqKey="Binkowski T" first="T. A." last="Binkowski">T. A. Binkowski</name><affiliation><nlm:aff id="A6">Midwest Centre for Structural Genomics, Argonne National Laboratory and Computation Institute, University of Chicago, USA</nlm:aff></affiliation></author><author><name sortKey="Hildebrand, W H" sort="Hildebrand, W H" uniqKey="Hildebrand W" first="W. H." last="Hildebrand">W. H. Hildebrand</name><affiliation><nlm:aff id="A7">Department of Microbiology and Immunology, University of Oklahoma, OK, USA</nlm:aff></affiliation></author><author><name sortKey="Scherer, A" sort="Scherer, A" uniqKey="Scherer A" first="A." last="Scherer">A. Scherer</name><affiliation><nlm:aff id="A8">Australian Genome Research Facility, Walter and Eliza Hall Institute, Parkville, Australia</nlm:aff></affiliation></author><author><name sortKey="Mansoor, M" sort="Mansoor, M" uniqKey="Mansoor M" first="M." last="Mansoor">M. Mansoor</name><affiliation><nlm:aff id="A9">Department Medicine, University of British Columbia, Vancouver, BC, Canada</nlm:aff></affiliation></author><author><name sortKey="Keown, P A" sort="Keown, P A" uniqKey="Keown P" first="P. A." last="Keown">P. A. Keown</name><affiliation><nlm:aff id="A9">Department Medicine, University of British Columbia, Vancouver, BC, Canada</nlm:aff></affiliation><affiliation><nlm:aff id="A10">Department of Pathology and Laboratory Medicine, University of British Columbia, Vancouver, BC, Canada</nlm:aff></affiliation></author></titleStmt><publicationStmt><idno type="wicri:source">PMC</idno><idno type="pmid">23933161</idno><idno type="pmc">4096956</idno><idno type="url">http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4096956</idno><idno type="RBID">PMC:4096956</idno><idno type="doi">10.1016/j.jprot.2013.08.001</idno><date when="2013">2013</date><idno type="wicri:Area/Pmc/Corpus">000759</idno><idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Corpus" wicri:corpus="PMC">000759</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en" level="a" type="main">The Human Proteome Organization Chromosome 6 Consortium: Integrating chromosome-centric and biology/disease driven strategies</title><author><name sortKey="Borchers, C H" sort="Borchers, C H" uniqKey="Borchers C" first="C. H." last="Borchers">C. H. Borchers</name><affiliation><nlm:aff id="A1">University of Victoria/Genome BC Proteomics Centre, Victoria, BC, Canada</nlm:aff></affiliation></author><author><name sortKey="Kast, J" sort="Kast, J" uniqKey="Kast J" first="J." last="Kast">J. Kast</name><affiliation><nlm:aff id="A2">Biomedical Research Centre, University of British Columbia, Vancouver, BC, Canada</nlm:aff></affiliation></author><author><name sortKey="Foster, L J" sort="Foster, L J" uniqKey="Foster L" first="L. J." last="Foster">L. J. Foster</name><affiliation><nlm:aff id="A3">Centre for High Throughput Biology, University of British Columbia, BC, Canada</nlm:aff></affiliation></author><author><name sortKey="Siu, K W M" sort="Siu, K W M" uniqKey="Siu K" first="K. W. M." last="Siu">K. W. M. Siu</name><affiliation><nlm:aff id="A4">Centre for Research in Mass Spectrometry, York University, Ontario, Canada</nlm:aff></affiliation></author><author><name sortKey="Overall, C M" sort="Overall, C M" uniqKey="Overall C" first="C. M." last="Overall">C. M. Overall</name><affiliation><nlm:aff id="A5">Centre for Blood Research, Faculty of Dentistry, University of British Columbia, Canada</nlm:aff></affiliation></author><author><name sortKey="Binkowski, T A" sort="Binkowski, T A" uniqKey="Binkowski T" first="T. A." last="Binkowski">T. A. Binkowski</name><affiliation><nlm:aff id="A6">Midwest Centre for Structural Genomics, Argonne National Laboratory and Computation Institute, University of Chicago, USA</nlm:aff></affiliation></author><author><name sortKey="Hildebrand, W H" sort="Hildebrand, W H" uniqKey="Hildebrand W" first="W. H." last="Hildebrand">W. H. Hildebrand</name><affiliation><nlm:aff id="A7">Department of Microbiology and Immunology, University of Oklahoma, OK, USA</nlm:aff></affiliation></author><author><name sortKey="Scherer, A" sort="Scherer, A" uniqKey="Scherer A" first="A." last="Scherer">A. Scherer</name><affiliation><nlm:aff id="A8">Australian Genome Research Facility, Walter and Eliza Hall Institute, Parkville, Australia</nlm:aff></affiliation></author><author><name sortKey="Mansoor, M" sort="Mansoor, M" uniqKey="Mansoor M" first="M." last="Mansoor">M. Mansoor</name><affiliation><nlm:aff id="A9">Department Medicine, University of British Columbia, Vancouver, BC, Canada</nlm:aff></affiliation></author><author><name sortKey="Keown, P A" sort="Keown, P A" uniqKey="Keown P" first="P. A." last="Keown">P. A. Keown</name><affiliation><nlm:aff id="A9">Department Medicine, University of British Columbia, Vancouver, BC, Canada</nlm:aff></affiliation><affiliation><nlm:aff id="A10">Department of Pathology and Laboratory Medicine, University of British Columbia, Vancouver, BC, Canada</nlm:aff></affiliation></author></analytic><series><title level="j">Journal of proteomics</title><idno type="ISSN">1874-3919</idno><idno type="eISSN">1876-7737</idno><imprint><date when="2013">2013</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en"><p id="P1">The Human Proteome Project (HPP) is designed to generate a comprehensive map of the protein-based molecular architecture of the human body, to provide a resource to help elucidate biological and molecular function, and to advance diagnosis and treatment of diseases. Within this framework, the chromosome-based HPP (C-HPP) has allocated responsibility for mapping individual chromosomes by country or region, while the biology/disease HPP (B/D-HPP) coordinates these teams in cross-functional disease-based groups. Chromosome 6 (Ch6) provides an excellent model for integration of these two tasks. This metacentric chromosome has a complement of 1002–1034 genes that code for known, novel or putative proteins. Ch6 is functionally associated with more than 120 major human diseases, many with high population prevalence, devastating clinical impact and profound societal consequences. The unique combination of genomic, proteomic, metabolomic, phenomic and health services data being drawn together within the Ch6 program has enormous potential to advance personalized medicine by promoting robust biomarkers, subunit vaccines and new drug targets. The strong liaison between the clinical and laboratory teams, and the structured framework for technology transfer and health policy decisions within Canada will increase the speed and efficacy of this transition, and the value of this translational research.</p><sec id="S1"><title>Biological significance</title><p id="P2">Canada has been selected to play a leading role in the international Human Proteome Project, the global counterpart of the Human Genome Project designed to understand the structure and function of the human proteome in health and disease. Canada will lead an international team focusing on chromosome 6, which is functionally associated with more than 120 major human diseases, including immune and inflammatory disorders affecting the brain, skeletal system, heart and blood vessels, lungs, kidney, liver, gastrointestinal tract and endocrine system. Many of these chronic and persistent diseases have a high population prevalence, devastating clinical impact and profound societal consequences. As a result, they impose a multi-billion dollar economic burden on Canada and on all advanced societies through direct costs of patient care, the loss of health and productivity, and extensive caregiver burden. There is no definitive treatment at the present time for any of these disorders.</p><p id="P3">The manuscript outlines the research which will involve a systematic assessment of all chromosome 6 genes, development of a knowledge base, and development of assays and reagents for all chromosome 6 proteins. We feel that the informatic infrastructure and MRM assays developed will place the chromosome 6 consortium in an excellent position to be a leading player in this major international research initiative.</p></sec></div></front></TEI><pmc article-type="research-article"><pmc-comment>The publisher of this article does not allow downloading of the full text in XML form.</pmc-comment>
<pmc-dir>properties manuscript</pmc-dir>
<front><journal-meta><journal-id journal-id-type="nlm-journal-id">101475056</journal-id><journal-id journal-id-type="pubmed-jr-id">34573</journal-id><journal-id journal-id-type="nlm-ta">J Proteomics</journal-id><journal-id journal-id-type="iso-abbrev">J Proteomics</journal-id><journal-title-group><journal-title>Journal of proteomics</journal-title></journal-title-group><issn pub-type="ppub">1874-3919</issn><issn pub-type="epub">1876-7737</issn></journal-meta><article-meta><article-id pub-id-type="pmid">23933161</article-id><article-id pub-id-type="pmc">4096956</article-id><article-id pub-id-type="doi">10.1016/j.jprot.2013.08.001</article-id><article-id pub-id-type="manuscript">NIHMS604930</article-id><article-categories><subj-group subj-group-type="heading"><subject>Article</subject></subj-group></article-categories><title-group><article-title>The Human Proteome Organization Chromosome 6 Consortium: Integrating chromosome-centric and biology/disease driven strategies</article-title></title-group><contrib-group><contrib contrib-type="author"><name><surname>Borchers</surname><given-names>C.H.</given-names></name><xref ref-type="aff" rid="A1">a</xref></contrib><contrib contrib-type="author"><name><surname>Kast</surname><given-names>J.</given-names></name><xref ref-type="aff" rid="A2">b</xref></contrib><contrib contrib-type="author"><name><surname>Foster</surname><given-names>L.J.</given-names></name><xref ref-type="aff" rid="A3">c</xref></contrib><contrib contrib-type="author"><name><surname>Siu</surname><given-names>K.W.M.</given-names></name><xref ref-type="aff" rid="A4">d</xref></contrib><contrib contrib-type="author"><name><surname>Overall</surname><given-names>C.M.</given-names></name><xref ref-type="aff" rid="A5">e</xref></contrib><contrib contrib-type="author"><name><surname>Binkowski</surname><given-names>T.A.</given-names></name><xref ref-type="aff" rid="A6">f</xref></contrib><contrib contrib-type="author"><name><surname>Hildebrand</surname><given-names>W.H.</given-names></name><xref ref-type="aff" rid="A7">g</xref></contrib><contrib contrib-type="author"><name><surname>Scherer</surname><given-names>A.</given-names></name><xref ref-type="aff" rid="A8">h</xref></contrib><contrib contrib-type="author"><name><surname>Mansoor</surname><given-names>M.</given-names></name><xref ref-type="aff" rid="A9">i</xref></contrib><contrib contrib-type="author"><name><surname>Keown</surname><given-names>P.A.</given-names></name><xref ref-type="aff" rid="A9">i</xref><xref ref-type="aff" rid="A10">j</xref><xref rid="FN1" ref-type="author-notes">*</xref></contrib><on-behalf-of>for the Human Proteome Organization Chromosome 6 Consortium</on-behalf-of></contrib-group><aff id="A1"><label>a</label>University of Victoria/Genome BC Proteomics Centre, Victoria, BC, Canada</aff><aff id="A2"><label>b</label>Biomedical Research Centre, University of British Columbia, Vancouver, BC, Canada</aff><aff id="A3"><label>c</label>Centre for High Throughput Biology, University of British Columbia, BC, Canada</aff><aff id="A4"><label>d</label>Centre for Research in Mass Spectrometry, York University, Ontario, Canada</aff><aff id="A5"><label>e</label>Centre for Blood Research, Faculty of Dentistry, University of British Columbia, Canada</aff><aff id="A6"><label>f</label>Midwest Centre for Structural Genomics, Argonne National Laboratory and Computation Institute, University of Chicago, USA</aff><aff id="A7"><label>g</label>Department of Microbiology and Immunology, University of Oklahoma, OK, USA</aff><aff id="A8"><label>h</label>Australian Genome Research Facility, Walter and Eliza Hall Institute, Parkville, Australia</aff><aff id="A9"><label>i</label>Department Medicine, University of British Columbia, Vancouver, BC, Canada</aff><aff id="A10"><label>j</label>Department of Pathology and Laboratory Medicine, University of British Columbia, Vancouver, BC, Canada</aff><author-notes><corresp id="FN1"><label>*</label>Corresponding author at: Department of Pathology and Laboratory Medicine, University of British Columbia, Room 1559, Immunology, Vancouver General Hospital, Vancouver V5Z1M9, Canada. Tel.: +1 604 875 4393; fax: +1 604 875 4911. <email>paul_keown@yahoo.com</email> (P.A. Keown)</corresp></author-notes><pub-date pub-type="nihms-submitted"><day>15</day><month>6</month><year>2014</year></pub-date><pub-date pub-type="epub"><day>08</day><month>8</month><year>2013</year></pub-date><pub-date pub-type="ppub"><day>4</day><month>4</month><year>2014</year></pub-date><pub-date pub-type="pmc-release"><day>04</day><month>4</month><year>2015</year></pub-date><volume>100</volume><fpage>60</fpage><lpage>67</lpage><pmc-comment>elocation-id from pubmed: 10.1016/j.jprot.2013.08.001</pmc-comment>
<permissions><copyright-statement>© 2013 Elsevier B.V. All rights reserved.</copyright-statement><copyright-year>2013</copyright-year></permissions><abstract><p id="P1">The Human Proteome Project (HPP) is designed to generate a comprehensive map of the protein-based molecular architecture of the human body, to provide a resource to help elucidate biological and molecular function, and to advance diagnosis and treatment of diseases. Within this framework, the chromosome-based HPP (C-HPP) has allocated responsibility for mapping individual chromosomes by country or region, while the biology/disease HPP (B/D-HPP) coordinates these teams in cross-functional disease-based groups. Chromosome 6 (Ch6) provides an excellent model for integration of these two tasks. This metacentric chromosome has a complement of 1002–1034 genes that code for known, novel or putative proteins. Ch6 is functionally associated with more than 120 major human diseases, many with high population prevalence, devastating clinical impact and profound societal consequences. The unique combination of genomic, proteomic, metabolomic, phenomic and health services data being drawn together within the Ch6 program has enormous potential to advance personalized medicine by promoting robust biomarkers, subunit vaccines and new drug targets. The strong liaison between the clinical and laboratory teams, and the structured framework for technology transfer and health policy decisions within Canada will increase the speed and efficacy of this transition, and the value of this translational research.</p><sec id="S1"><title>Biological significance</title><p id="P2">Canada has been selected to play a leading role in the international Human Proteome Project, the global counterpart of the Human Genome Project designed to understand the structure and function of the human proteome in health and disease. Canada will lead an international team focusing on chromosome 6, which is functionally associated with more than 120 major human diseases, including immune and inflammatory disorders affecting the brain, skeletal system, heart and blood vessels, lungs, kidney, liver, gastrointestinal tract and endocrine system. Many of these chronic and persistent diseases have a high population prevalence, devastating clinical impact and profound societal consequences. As a result, they impose a multi-billion dollar economic burden on Canada and on all advanced societies through direct costs of patient care, the loss of health and productivity, and extensive caregiver burden. There is no definitive treatment at the present time for any of these disorders.</p><p id="P3">The manuscript outlines the research which will involve a systematic assessment of all chromosome 6 genes, development of a knowledge base, and development of assays and reagents for all chromosome 6 proteins. We feel that the informatic infrastructure and MRM assays developed will place the chromosome 6 consortium in an excellent position to be a leading player in this major international research initiative.</p></sec></abstract><kwd-group><kwd>Human Proteome Project</kwd><kwd>Proteomics</kwd><kwd>Chromosome 6</kwd></kwd-group></article-meta></front></pmc></record>Pour manipuler ce document sous Unix (Dilib)
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