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<record><TEI><teiHeader><fileDesc><titleStmt><title xml:lang="en">REM Sleep Characteristics in Narcolepsy and REM Sleep Behavior Disorder</title><author><name sortKey="Dauvilliers, Yves" sort="Dauvilliers, Yves" uniqKey="Dauvilliers Y" first="Yves" last="Dauvilliers">Yves Dauvilliers</name><affiliation><nlm:aff id="aff1">Department of Neurology, Hôpital Gui de Chauliac, Inserm, U888, Université de Montpellier 1, Montpellier, France</nlm:aff></affiliation></author><author><name sortKey="Rompre, Sylvie" sort="Rompre, Sylvie" uniqKey="Rompre S" first="Sylvie" last="Rompré">Sylvie Rompré</name><affiliation><nlm:aff id="aff2">Sleep Disorders Center, Hôpital du Sacré-Cœur, Université de Montréal, Canada</nlm:aff></affiliation></author><author><name sortKey="Gagnon, Jean Francis" sort="Gagnon, Jean Francis" uniqKey="Gagnon J" first="Jean-Françis" last="Gagnon">Jean-Françis Gagnon</name><affiliation><nlm:aff id="aff2">Sleep Disorders Center, Hôpital du Sacré-Cœur, Université de Montréal, Canada</nlm:aff></affiliation></author><author><name sortKey="Vendette, Melanie" sort="Vendette, Melanie" uniqKey="Vendette M" first="Mélanie" last="Vendette">Mélanie Vendette</name><affiliation><nlm:aff id="aff2">Sleep Disorders Center, Hôpital du Sacré-Cœur, Université de Montréal, Canada</nlm:aff></affiliation></author><author><name sortKey="Petit, Dominique" sort="Petit, Dominique" uniqKey="Petit D" first="Dominique" last="Petit">Dominique Petit</name><affiliation><nlm:aff id="aff2">Sleep Disorders Center, Hôpital du Sacré-Cœur, Université de Montréal, Canada</nlm:aff></affiliation></author><author><name sortKey="Montplaisir, Jacques" sort="Montplaisir, Jacques" uniqKey="Montplaisir J" first="Jacques" last="Montplaisir">Jacques Montplaisir</name><affiliation><nlm:aff id="aff2">Sleep Disorders Center, Hôpital du Sacré-Cœur, Université de Montréal, Canada</nlm:aff></affiliation></author></titleStmt><publicationStmt><idno type="wicri:source">PMC</idno><idno type="pmid">17682654</idno><idno type="pmc">1978363</idno><idno type="url">http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1978363</idno><idno type="RBID">PMC:1978363</idno><date when="2007">2007</date><idno type="wicri:Area/Pmc/Corpus">000691</idno><idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Corpus" wicri:corpus="PMC">000691</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en" level="a" type="main">REM Sleep Characteristics in Narcolepsy and REM Sleep Behavior Disorder</title><author><name sortKey="Dauvilliers, Yves" sort="Dauvilliers, Yves" uniqKey="Dauvilliers Y" first="Yves" last="Dauvilliers">Yves Dauvilliers</name><affiliation><nlm:aff id="aff1">Department of Neurology, Hôpital Gui de Chauliac, Inserm, U888, Université de Montpellier 1, Montpellier, France</nlm:aff></affiliation></author><author><name sortKey="Rompre, Sylvie" sort="Rompre, Sylvie" uniqKey="Rompre S" first="Sylvie" last="Rompré">Sylvie Rompré</name><affiliation><nlm:aff id="aff2">Sleep Disorders Center, Hôpital du Sacré-Cœur, Université de Montréal, Canada</nlm:aff></affiliation></author><author><name sortKey="Gagnon, Jean Francis" sort="Gagnon, Jean Francis" uniqKey="Gagnon J" first="Jean-Françis" last="Gagnon">Jean-Françis Gagnon</name><affiliation><nlm:aff id="aff2">Sleep Disorders Center, Hôpital du Sacré-Cœur, Université de Montréal, Canada</nlm:aff></affiliation></author><author><name sortKey="Vendette, Melanie" sort="Vendette, Melanie" uniqKey="Vendette M" first="Mélanie" last="Vendette">Mélanie Vendette</name><affiliation><nlm:aff id="aff2">Sleep Disorders Center, Hôpital du Sacré-Cœur, Université de Montréal, Canada</nlm:aff></affiliation></author><author><name sortKey="Petit, Dominique" sort="Petit, Dominique" uniqKey="Petit D" first="Dominique" last="Petit">Dominique Petit</name><affiliation><nlm:aff id="aff2">Sleep Disorders Center, Hôpital du Sacré-Cœur, Université de Montréal, Canada</nlm:aff></affiliation></author><author><name sortKey="Montplaisir, Jacques" sort="Montplaisir, Jacques" uniqKey="Montplaisir J" first="Jacques" last="Montplaisir">Jacques Montplaisir</name><affiliation><nlm:aff id="aff2">Sleep Disorders Center, Hôpital du Sacré-Cœur, Université de Montréal, Canada</nlm:aff></affiliation></author></analytic><series><title level="j">Sleep</title><idno type="ISSN">0161-8105</idno><idno type="eISSN">1550-9109</idno><imprint><date when="2007">2007</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en"><sec><title>Study Objectives:</title><p>To assess the presence of polysomnographic characteristics of REM sleep behavior disorder (RBD) in narcolepsy; and to quantify REM sleep parameters in patients with narcolepsy, in patients with “idiopathic” RBD, and in normal controls.</p></sec><sec><title>Design:</title><p>Sleep laboratory study</p></sec><sec><title>Participants:</title><p>Sixteen patients with narcolepsy and cataplexy matched for age and sex with 16 patients with “idiopathic” RBD and with 16 normal controls were studied.</p></sec><sec><title>Measurements and Results:</title><p>Higher percentages of REM sleep without atonia, phasic electromyographic (EMG) activity, and REM density were found in patients with narcolepsy than normal controls. In contrast, RBD patients had a higher percentage of REM sleep without atonia but a lower REM density than patients with narcolepsy and normal controls. Based on a threshold of 80% for percentage of REM sleep with atonia, 50% of narcoleptics and 87.5% of RBD patients had abnormal REM sleep muscle activity. No significant behavioral manifestation in REM sleep was noted in either narcoleptics or controls. We also found a higher frequency of periodic leg movements during wake (PLMW) and during sleep (PLMS) in narcoleptic patients compared to controls.</p></sec><sec><title>Conclusions:</title><p>The present study demonstrates abnormalities in REM sleep motor regulation with an increased frequency of REM sleep without atonia, phasic EMG events and PLMS in narcoleptic patients when compared to controls. These abnormalities were seen more prominently in patients with RBD than in narcoleptics, with the exception of the PLMS index. We proposed that dysfunctions in hypocretin/dopaminergic system may lead to motor dyscontrol in REM sleep that results in dissociated sleep/wake states.</p></sec><sec><title>Citation:</title><p>Dauvilliers Y; Rompré S; Gagnon JF et al. REM sleep characteristics in narcolepsy and REM sleep behavior disorder. <italic>SLEEP</italic> 2007;30(7):844-849.</p></sec></div></front></TEI><pmc article-type="research-article"><pmc-comment>The publisher of this article does not allow downloading of the full text in XML form.</pmc-comment>
<front><journal-meta><journal-id journal-id-type="nlm-ta">Sleep</journal-id><journal-id journal-id-type="publisher-id">Sleep</journal-id><journal-title>Sleep</journal-title><issn pub-type="ppub">0161-8105</issn><issn pub-type="epub">1550-9109</issn><publisher><publisher-name>Associated Professional Sleep Societies, LLC</publisher-name></publisher></journal-meta><article-meta><article-id pub-id-type="pmid">17682654</article-id><article-id pub-id-type="pmc">1978363</article-id><article-categories><subj-group subj-group-type="heading"><subject>REM Sleep</subject></subj-group></article-categories><title-group><article-title>REM Sleep Characteristics in Narcolepsy and REM Sleep Behavior Disorder</article-title></title-group><contrib-group><contrib contrib-type="author"><name><surname>Dauvilliers</surname><given-names>Yves</given-names></name><degrees>MD, PhD</degrees><xref ref-type="aff" rid="aff1"><sup>1</sup></xref></contrib><contrib contrib-type="author"><name><surname>Rompré</surname><given-names>Sylvie</given-names></name><xref ref-type="aff" rid="aff2"><sup>2</sup></xref></contrib><contrib contrib-type="author"><name><surname>Gagnon</surname><given-names>Jean-Françis</given-names></name><degrees>PhD</degrees><xref ref-type="aff" rid="aff2"><sup>2</sup></xref></contrib><contrib contrib-type="author"><name><surname>Vendette</surname><given-names>Mélanie</given-names></name><degrees>BSc</degrees><xref ref-type="aff" rid="aff2"><sup>2</sup></xref></contrib><contrib contrib-type="author"><name><surname>Petit</surname><given-names>Dominique</given-names></name><degrees>PhD</degrees><xref ref-type="aff" rid="aff2"><sup>2</sup></xref></contrib><contrib contrib-type="author"><name><surname>Montplaisir</surname><given-names>Jacques</given-names></name><degrees>MD, PhD</degrees><xref ref-type="aff" rid="aff2"><sup>2</sup></xref><xref ref-type="corresp" rid="cor1"></xref></contrib><aff id="aff1"><label>1</label>Department of Neurology, Hôpital Gui de Chauliac, Inserm, U888, Université de Montpellier 1, Montpellier, France</aff><aff id="aff2"><label>2</label>Sleep Disorders Center, Hôpital du Sacré-Cœur, Université de Montréal, Canada</aff></contrib-group><author-notes><corresp id="cor1">Address correspondence to: Jacques Montplaisir, MD, PhD,
<addr-line>Centre d'étude du sommeil et des rythmes biologiques, Hôpital du Sacré-Coeur de Montréal, 5400 boul. Gouin Ouest, Montreal, Quebec, Canada, H4J 1C5</addr-line><phone>(514) 338-2693</phone><fax>(514) 338-2531</fax><email>jy.montplaisir@umontreal.ca</email></corresp></author-notes><pub-date pub-type="ppub"><day>1</day><month>7</month><year>2007</year></pub-date><volume>30</volume><issue>7</issue><fpage>844</fpage><lpage>849</lpage><history><date date-type="received"><month>2</month><year>2007</year></date><date date-type="accepted"><month>4</month><year>2007</year></date></history><copyright-statement>© 2007 Associated Professional Sleep Societies, LLC.</copyright-statement><copyright-year>2007</copyright-year><abstract><sec><title>Study Objectives:</title><p>To assess the presence of polysomnographic characteristics of REM sleep behavior disorder (RBD) in narcolepsy; and to quantify REM sleep parameters in patients with narcolepsy, in patients with “idiopathic” RBD, and in normal controls.</p></sec><sec><title>Design:</title><p>Sleep laboratory study</p></sec><sec><title>Participants:</title><p>Sixteen patients with narcolepsy and cataplexy matched for age and sex with 16 patients with “idiopathic” RBD and with 16 normal controls were studied.</p></sec><sec><title>Measurements and Results:</title><p>Higher percentages of REM sleep without atonia, phasic electromyographic (EMG) activity, and REM density were found in patients with narcolepsy than normal controls. In contrast, RBD patients had a higher percentage of REM sleep without atonia but a lower REM density than patients with narcolepsy and normal controls. Based on a threshold of 80% for percentage of REM sleep with atonia, 50% of narcoleptics and 87.5% of RBD patients had abnormal REM sleep muscle activity. No significant behavioral manifestation in REM sleep was noted in either narcoleptics or controls. We also found a higher frequency of periodic leg movements during wake (PLMW) and during sleep (PLMS) in narcoleptic patients compared to controls.</p></sec><sec><title>Conclusions:</title><p>The present study demonstrates abnormalities in REM sleep motor regulation with an increased frequency of REM sleep without atonia, phasic EMG events and PLMS in narcoleptic patients when compared to controls. These abnormalities were seen more prominently in patients with RBD than in narcoleptics, with the exception of the PLMS index. We proposed that dysfunctions in hypocretin/dopaminergic system may lead to motor dyscontrol in REM sleep that results in dissociated sleep/wake states.</p></sec><sec><title>Citation:</title><p>Dauvilliers Y; Rompré S; Gagnon JF et al. REM sleep characteristics in narcolepsy and REM sleep behavior disorder. <italic>SLEEP</italic> 2007;30(7):844-849.</p></sec></abstract><kwd-group><kwd>Narcolepsy</kwd><kwd>cataplexy</kwd><kwd>REM sleep</kwd><kwd>Muscle tone</kwd><kwd>PLM</kwd><kwd>RBD</kwd></kwd-group></article-meta></front></pmc></record>Pour manipuler ce document sous Unix (Dilib)
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