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<record><TEI><teiHeader><fileDesc><titleStmt><title xml:lang="en">Increased Fragmentation of Rest-Activity Patterns Is Associated With a Characteristic Pattern of Cognitive Impairment in Older Individuals</title><author><name sortKey="Lim, Andrew S P" sort="Lim, Andrew S P" uniqKey="Lim A" first="Andrew S. P." last="Lim">Andrew S. P. Lim</name><affiliation><nlm:aff id="aff1">Department of Neurology, Beth Israel Deaconess Medical Center, Boston, MA</nlm:aff></affiliation><affiliation><nlm:aff id="aff2">Division of Neurology, Department of Medicine, Sunnybrook Health Sciences Centre, University of Toronto, Toronto, ON, Canada</nlm:aff></affiliation></author><author><name sortKey="Yu, Lei" sort="Yu, Lei" uniqKey="Yu L" first="Lei" last="Yu">Lei Yu</name><affiliation><nlm:aff id="aff3">Rush Alzheimer's Disease Center, Rush University Medical Center, Chicago, IL</nlm:aff></affiliation></author><author><name sortKey="Costa, Madalena D" sort="Costa, Madalena D" uniqKey="Costa M" first="Madalena D." last="Costa">Madalena D. Costa</name><affiliation><nlm:aff id="aff4">Margaret and H.A. Rey Institute of Nonlinear Dynamics in Physiology, Beth Israel Deaconess Medical Center, Boston, MA</nlm:aff></affiliation><affiliation><nlm:aff id="aff5">Wyss Institute for Biologically Inspired Engineering, Boston, MA</nlm:aff></affiliation></author><author><name sortKey="Leurgans, Sue E" sort="Leurgans, Sue E" uniqKey="Leurgans S" first="Sue E." last="Leurgans">Sue E. Leurgans</name><affiliation><nlm:aff id="aff3">Rush Alzheimer's Disease Center, Rush University Medical Center, Chicago, IL</nlm:aff></affiliation></author><author><name sortKey="Buchman, Aron S" sort="Buchman, Aron S" uniqKey="Buchman A" first="Aron S." last="Buchman">Aron S. Buchman</name><affiliation><nlm:aff id="aff3">Rush Alzheimer's Disease Center, Rush University Medical Center, Chicago, IL</nlm:aff></affiliation></author><author><name sortKey="Bennett, David A" sort="Bennett, David A" uniqKey="Bennett D" first="David A." last="Bennett">David A. Bennett</name><affiliation><nlm:aff id="aff3">Rush Alzheimer's Disease Center, Rush University Medical Center, Chicago, IL</nlm:aff></affiliation></author><author><name sortKey="Saper, Clifford B" sort="Saper, Clifford B" uniqKey="Saper C" first="Clifford B." last="Saper">Clifford B. Saper</name><affiliation><nlm:aff id="aff1">Department of Neurology, Beth Israel Deaconess Medical Center, Boston, MA</nlm:aff></affiliation></author></titleStmt><publicationStmt><idno type="wicri:source">PMC</idno><idno type="pmid">22547889</idno><idno type="pmc">3321422</idno><idno type="url">http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3321422</idno><idno type="RBID">PMC:3321422</idno><idno type="doi">10.5665/sleep.1820</idno><date when="2012">2012</date><idno type="wicri:Area/Pmc/Corpus">000682</idno><idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Corpus" wicri:corpus="PMC">000682</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en" level="a" type="main">Increased Fragmentation of Rest-Activity Patterns Is Associated With a Characteristic Pattern of Cognitive Impairment in Older Individuals</title><author><name sortKey="Lim, Andrew S P" sort="Lim, Andrew S P" uniqKey="Lim A" first="Andrew S. P." last="Lim">Andrew S. P. Lim</name><affiliation><nlm:aff id="aff1">Department of Neurology, Beth Israel Deaconess Medical Center, Boston, MA</nlm:aff></affiliation><affiliation><nlm:aff id="aff2">Division of Neurology, Department of Medicine, Sunnybrook Health Sciences Centre, University of Toronto, Toronto, ON, Canada</nlm:aff></affiliation></author><author><name sortKey="Yu, Lei" sort="Yu, Lei" uniqKey="Yu L" first="Lei" last="Yu">Lei Yu</name><affiliation><nlm:aff id="aff3">Rush Alzheimer's Disease Center, Rush University Medical Center, Chicago, IL</nlm:aff></affiliation></author><author><name sortKey="Costa, Madalena D" sort="Costa, Madalena D" uniqKey="Costa M" first="Madalena D." last="Costa">Madalena D. Costa</name><affiliation><nlm:aff id="aff4">Margaret and H.A. Rey Institute of Nonlinear Dynamics in Physiology, Beth Israel Deaconess Medical Center, Boston, MA</nlm:aff></affiliation><affiliation><nlm:aff id="aff5">Wyss Institute for Biologically Inspired Engineering, Boston, MA</nlm:aff></affiliation></author><author><name sortKey="Leurgans, Sue E" sort="Leurgans, Sue E" uniqKey="Leurgans S" first="Sue E." last="Leurgans">Sue E. Leurgans</name><affiliation><nlm:aff id="aff3">Rush Alzheimer's Disease Center, Rush University Medical Center, Chicago, IL</nlm:aff></affiliation></author><author><name sortKey="Buchman, Aron S" sort="Buchman, Aron S" uniqKey="Buchman A" first="Aron S." last="Buchman">Aron S. Buchman</name><affiliation><nlm:aff id="aff3">Rush Alzheimer's Disease Center, Rush University Medical Center, Chicago, IL</nlm:aff></affiliation></author><author><name sortKey="Bennett, David A" sort="Bennett, David A" uniqKey="Bennett D" first="David A." last="Bennett">David A. Bennett</name><affiliation><nlm:aff id="aff3">Rush Alzheimer's Disease Center, Rush University Medical Center, Chicago, IL</nlm:aff></affiliation></author><author><name sortKey="Saper, Clifford B" sort="Saper, Clifford B" uniqKey="Saper C" first="Clifford B." last="Saper">Clifford B. Saper</name><affiliation><nlm:aff id="aff1">Department of Neurology, Beth Israel Deaconess Medical Center, Boston, MA</nlm:aff></affiliation></author></analytic><series><title level="j">Sleep</title><idno type="ISSN">0161-8105</idno><idno type="eISSN">1550-9109</idno><imprint><date when="2012">2012</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en"><sec><title>Study Objectives:</title><p>Aging is accompanied by changes in cognitive function, and changes in rest-activity patterns. Previous work has demonstrated associations between global rest-activity measures and cognitive performance on a number of tasks. Recently, we demonstrated that aging is associated with changes in the minute-to-minute fragmentation of rest-activity patterns in addition to changes in amounts of rest and activity. Given the body of experimental evidence linking sleep fragmentation with decrements in cognitive function in animals and humans, we hypothesized that increased fragmentation of rest-activity patterns would be associated with decreased cognitive function in older individuals.</p></sec><sec><title>Design:</title><p>Cross-sectional.</p></sec><sec><title>Participants:</title><p>700 community-dwelling individuals from the Rush Memory and Aging Project.</p></sec><sec><title>Measurements and Results:</title><p>We obtained up to 11 days of actigraphic recordings in subjects' home environments and quantified the fragmentation of rest and activity using a recently developed state transition metric. We tested the associations between this metric and performance in 5 cognitive domains. Greater fragmentation of both rest and activity were associated with lower levels of cognitive performance, and this association was independent of total amounts of rest or activity. There was a characteristic pattern of cognitive deficits associated with rest and activity fragmentation, with preferential involvement of perceptual speed, semantic memory, working memory, and visuospatial abilities, and relative sparing of episodic memory.</p></sec><sec><title>Conclusions:</title><p>The fragmentation of periods of rest and activity is a clinically important characteristic of rest-activity patterns that correlates with cognitive performance in older individuals.</p></sec><sec><title>Citation:</title><p>Lim ASP; Yu L; Costa MD; Leurgans SE; Buchman AS; Bennett DA; Saper CB. Increased fragmentation of rest-activity patterns is associated with a characteristic pattern of cognitive impairment in older individuals. <italic>SLEEP</italic> 2012;35(5):633-640.</p></sec></div></front></TEI><pmc article-type="research-article"><pmc-comment>The publisher of this article does not allow downloading of the full text in XML form.</pmc-comment>
<front><journal-meta><journal-id journal-id-type="nlm-ta">Sleep</journal-id><journal-id journal-id-type="iso-abbrev">Sleep</journal-id><journal-id journal-id-type="publisher-id">Sleep</journal-id><journal-title-group><journal-title>Sleep</journal-title></journal-title-group><issn pub-type="ppub">0161-8105</issn><issn pub-type="epub">1550-9109</issn><publisher><publisher-name>Associated Professional Sleep Societies, LLC</publisher-name></publisher></journal-meta><article-meta><article-id pub-id-type="pmid">22547889</article-id><article-id pub-id-type="pmc">3321422</article-id><article-id pub-id-type="doi">10.5665/sleep.1820</article-id><article-categories><subj-group subj-group-type="heading"><subject>Fragmentation of Rest-Activity and Cognitive Impairment in Older Adults</subject></subj-group></article-categories><title-group><article-title>Increased Fragmentation of Rest-Activity Patterns Is Associated With a Characteristic Pattern of Cognitive Impairment in Older Individuals</article-title></title-group><contrib-group><contrib contrib-type="author"><name><surname>Lim</surname><given-names>Andrew S. P.</given-names></name><degrees>MD</degrees><xref ref-type="aff" rid="aff1"><sup>1</sup></xref><xref ref-type="aff" rid="aff2"><sup>2</sup></xref></contrib><contrib contrib-type="author"><name><surname>Yu</surname><given-names>Lei</given-names></name><degrees>PhD</degrees><xref ref-type="aff" rid="aff3"><sup>3</sup></xref></contrib><contrib contrib-type="author"><name><surname>Costa</surname><given-names>Madalena D.</given-names></name><degrees>PhD</degrees><xref ref-type="aff" rid="aff4"><sup>4</sup></xref><xref ref-type="aff" rid="aff5"><sup>5</sup></xref></contrib><contrib contrib-type="author"><name><surname>Leurgans</surname><given-names>Sue E.</given-names></name><degrees>PhD</degrees><xref ref-type="aff" rid="aff3"><sup>3</sup></xref></contrib><contrib contrib-type="author"><name><surname>Buchman</surname><given-names>Aron S.</given-names></name><degrees>MD</degrees><xref ref-type="aff" rid="aff3"><sup>3</sup></xref></contrib><contrib contrib-type="author"><name><surname>Bennett</surname><given-names>David A.</given-names></name><degrees>MD</degrees><xref ref-type="aff" rid="aff3"><sup>3</sup></xref></contrib><contrib contrib-type="author"><name><surname>Saper</surname><given-names>Clifford B.</given-names></name><degrees>MD, PhD</degrees><xref ref-type="aff" rid="aff1"><sup>1</sup></xref><xref ref-type="corresp" rid="cor1"></xref></contrib><aff id="aff1"><label>1</label>Department of Neurology, Beth Israel Deaconess Medical Center, Boston, MA</aff><aff id="aff2"><label>2</label>Division of Neurology, Department of Medicine, Sunnybrook Health Sciences Centre, University of Toronto, Toronto, ON, Canada</aff><aff id="aff3"><label>3</label>Rush Alzheimer's Disease Center, Rush University Medical Center, Chicago, IL</aff><aff id="aff4"><label>4</label>Margaret and H.A. Rey Institute of Nonlinear Dynamics in Physiology, Beth Israel Deaconess Medical Center, Boston, MA</aff><aff id="aff5"><label>5</label>Wyss Institute for Biologically Inspired Engineering, Boston, MA</aff></contrib-group><author-notes><corresp id="cor1">Address correspondence to: Clifford Saper, MD, PhD, <addr-line>Room CLS-717, 3 Blackfan Circle, Boston MA, 02215</addr-line><phone>(617) 735-3251</phone><fax>(617) 667-0810</fax><email>csaper@bidmc.harvard.edu</email></corresp></author-notes><pub-date pub-type="epub"><day>1</day><month>5</month><year>2012</year></pub-date><volume>35</volume><issue>5</issue><fpage>633</fpage><lpage>640</lpage><history><date date-type="received"><month>6</month><year>2011</year></date><date date-type="rev-recd"><month>10</month><year>2011</year></date><date date-type="accepted"><month>11</month><year>2011</year></date></history><permissions><copyright-statement>© 2012 Associated Professional Sleep Societies, LLC.</copyright-statement><copyright-year>2012</copyright-year></permissions><abstract><sec><title>Study Objectives:</title><p>Aging is accompanied by changes in cognitive function, and changes in rest-activity patterns. Previous work has demonstrated associations between global rest-activity measures and cognitive performance on a number of tasks. Recently, we demonstrated that aging is associated with changes in the minute-to-minute fragmentation of rest-activity patterns in addition to changes in amounts of rest and activity. Given the body of experimental evidence linking sleep fragmentation with decrements in cognitive function in animals and humans, we hypothesized that increased fragmentation of rest-activity patterns would be associated with decreased cognitive function in older individuals.</p></sec><sec><title>Design:</title><p>Cross-sectional.</p></sec><sec><title>Participants:</title><p>700 community-dwelling individuals from the Rush Memory and Aging Project.</p></sec><sec><title>Measurements and Results:</title><p>We obtained up to 11 days of actigraphic recordings in subjects' home environments and quantified the fragmentation of rest and activity using a recently developed state transition metric. We tested the associations between this metric and performance in 5 cognitive domains. Greater fragmentation of both rest and activity were associated with lower levels of cognitive performance, and this association was independent of total amounts of rest or activity. There was a characteristic pattern of cognitive deficits associated with rest and activity fragmentation, with preferential involvement of perceptual speed, semantic memory, working memory, and visuospatial abilities, and relative sparing of episodic memory.</p></sec><sec><title>Conclusions:</title><p>The fragmentation of periods of rest and activity is a clinically important characteristic of rest-activity patterns that correlates with cognitive performance in older individuals.</p></sec><sec><title>Citation:</title><p>Lim ASP; Yu L; Costa MD; Leurgans SE; Buchman AS; Bennett DA; Saper CB. Increased fragmentation of rest-activity patterns is associated with a characteristic pattern of cognitive impairment in older individuals. <italic>SLEEP</italic> 2012;35(5):633-640.</p></sec></abstract><kwd-group><kwd>Actigraphy</kwd><kwd>sleep fragmentation</kwd><kwd>cognition</kwd><kwd>aging</kwd></kwd-group></article-meta></front></pmc></record>Pour manipuler ce document sous Unix (Dilib)
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