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<record><TEI><teiHeader><fileDesc><titleStmt><title xml:lang="en">Emerging complexity of the HuD/ELAVl4 gene; implications for neuronal development, function, and dysfunction</title><author><name sortKey="Bronicki, Lucas M" sort="Bronicki, Lucas M" uniqKey="Bronicki L" first="Lucas M." last="Bronicki">Lucas M. Bronicki</name></author><author><name sortKey="Jasmin, Bernard J" sort="Jasmin, Bernard J" uniqKey="Jasmin B" first="Bernard J." last="Jasmin">Bernard J. Jasmin</name></author></titleStmt><publicationStmt><idno type="wicri:source">PMC</idno><idno type="pmid">23861535</idno><idno type="pmc">3708524</idno><idno type="url">http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3708524</idno><idno type="RBID">PMC:3708524</idno><idno type="doi">10.1261/rna.039164.113</idno><date when="2013">2013</date><idno type="wicri:Area/Pmc/Corpus">000680</idno><idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Corpus" wicri:corpus="PMC">000680</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en" level="a" type="main">Emerging complexity of the HuD/ELAVl4 gene; implications for neuronal development, function, and dysfunction</title><author><name sortKey="Bronicki, Lucas M" sort="Bronicki, Lucas M" uniqKey="Bronicki L" first="Lucas M." last="Bronicki">Lucas M. Bronicki</name></author><author><name sortKey="Jasmin, Bernard J" sort="Jasmin, Bernard J" uniqKey="Jasmin B" first="Bernard J." last="Jasmin">Bernard J. Jasmin</name></author></analytic><series><title level="j">RNA</title><idno type="ISSN">1355-8382</idno><idno type="eISSN">1469-9001</idno><imprint><date when="2013">2013</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en"><p>HuD is an RNA-binding protein that has been implicated in a wide variety of regulatory processes involving mRNA metabolism in neurons. This review provides a detailed overview of our current understanding of the roles of HuD in the nervous system.</p></div></front></TEI><pmc article-type="research-article"><pmc-comment>The publisher of this article does not allow downloading of the full text in XML form.</pmc-comment>
<front><journal-meta><journal-id journal-id-type="nlm-ta">RNA</journal-id><journal-id journal-id-type="iso-abbrev">RNA</journal-id><journal-id journal-id-type="publisher-id">RNA</journal-id><journal-title-group><journal-title>RNA</journal-title></journal-title-group><issn pub-type="ppub">1355-8382</issn><issn pub-type="epub">1469-9001</issn><publisher><publisher-name>Cold Spring Harbor Laboratory Press</publisher-name></publisher></journal-meta><article-meta><article-id pub-id-type="pmid">23861535</article-id><article-id pub-id-type="pmc">3708524</article-id><article-id pub-id-type="medline">9509184</article-id><article-id pub-id-type="publisher-id">NC</article-id><article-id pub-id-type="doi">10.1261/rna.039164.113</article-id><article-categories><subj-group subj-group-type="heading"><subject>Reviews</subject></subj-group></article-categories><title-group><article-title>Emerging complexity of the HuD/ELAVl4 gene; implications for neuronal development, function, and dysfunction</article-title><alt-title alt-title-type="left-running">Bronicki and Jasmin</alt-title><alt-title alt-title-type="right-running">Expression, function, and regulation of HuD</alt-title></title-group><contrib-group><contrib contrib-type="author"><name><surname>Bronicki</surname><given-names>Lucas M.</given-names></name></contrib><contrib contrib-type="author"><name><surname>Jasmin</surname><given-names>Bernard J.</given-names></name><xref ref-type="corresp" rid="cor1">1</xref></contrib></contrib-group><aff>Department of Cellular and Molecular Medicine, Faculty of Medicine, University of Ottawa, Ottawa, Ontario, Canada K1H 8M5</aff><author-notes><corresp id="cor1"><label>1</label><bold>Corresponding author</bold><bold>E-mail <email xlink:type="simple">jasmin@uottawa.ca</email></bold></corresp></author-notes><pub-date pub-type="ppub"><month>8</month><year>2013</year></pub-date><volume>19</volume><issue>8</issue><fpage>1019</fpage><lpage>1037</lpage><permissions><copyright-statement>© 2013; Published by Cold Spring Harbor Laboratory Press for the RNA Society</copyright-statement><copyright-year>2013</copyright-year><license license-type="creative-commons" xlink:href="http://creativecommons.org/licenses/by-nc/3.0/"><license-p>This article is distributed exclusively by the RNA Society for the first 12 months after the full-issue publication date (see <ext-link ext-link-type="uri" xlink:href="http://rnajournal.cshlp.org/site/misc/terms.xhtml">http://rnajournal.cshlp.org/site/misc/terms.xhtml</ext-link>). After 12 months, it is available under a Creative Commons License (Attribution-NonCommercial 3.0 Unported), as described at <ext-link ext-link-type="uri" xlink:href="http://creativecommons.org/licenses/by-nc/3.0/">http://creativecommons.org/licenses/by-nc/3.0/</ext-link>.</license-p></license></permissions><self-uri content-type="pdf" xlink:type="simple" xlink:href="1019.pdf"></self-uri><abstract abstract-type="precis"><p>HuD is an RNA-binding protein that has been implicated in a wide variety of regulatory processes involving mRNA metabolism in neurons. This review provides a detailed overview of our current understanding of the roles of HuD in the nervous system.</p></abstract><abstract><p>Precise control of messenger RNA (mRNA) processing and abundance are increasingly being recognized as critical for proper spatiotemporal gene expression, particularly in neurons. These regulatory events are governed by a large number of <italic>trans</italic>-acting factors found in neurons, most notably RNA-binding proteins (RBPs) and micro-RNAs (miRs), which bind to specific <italic>cis</italic>-acting elements or structures within mRNAs. Through this binding mechanism, <italic>trans</italic>-acting factors, particularly RBPs, control all aspects of mRNA metabolism, ranging from altering the transcription rate to mediating mRNA degradation. In this context the best-characterized neuronal RBP, the Hu/ELAVl family member HuD, is emerging as a key component in multiple regulatory processes—including pre-mRNA processing, mRNA stability, and translation—governing the fate of a substantial amount of neuronal mRNAs. Through its ability to regulate mRNA metabolism of diverse groups of functionally similar genes, HuD plays important roles in neuronal development and function. Furthermore, compelling evidence indicates supplementary roles for HuD in neuronal plasticity, in particular, recovery from axonal injury, learning and memory, and multiple neurological diseases. The purpose of this review is to provide a detailed overview of the current knowledge surrounding the expression and roles of HuD in the nervous system. Additionally, we outline the present understanding of the molecular mechanisms presiding over the localization, abundance, and function of HuD in neurons.</p></abstract><kwd-group><kwd>HuD/ELAVl4</kwd><kwd>RNA-binding protein</kwd><kwd>mRNA metabolism</kwd><kwd>post-transcriptional regulation</kwd></kwd-group></article-meta></front></pmc></record>Pour manipuler ce document sous Unix (Dilib)
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