Tryptophan Catabolism and Vitamin B-6 Status Are Affected by Gender and Lifestyle Factors in Healthy Young Adults123
Identifieur interne : 000594 ( Pmc/Corpus ); précédent : 000593; suivant : 000595Tryptophan Catabolism and Vitamin B-6 Status Are Affected by Gender and Lifestyle Factors in Healthy Young Adults123
Auteurs : Oana M. Deac ; James L. Mills ; Barry Shane ; Ivind Midttun ; Per M. Ueland ; John T. Brosnan ; Margaret E. Brosnan ; Eamon Laird ; Eileen R. Gibney ; Ruzong Fan ; Yifan Wang ; Lawrence C. Brody ; Anne M. MolloySource :
- The Journal of Nutrition [ 0022-3166 ] ; 2015.
Abstract
Url:
DOI: 10.3945/jn.114.203091
PubMed: 25833774
PubMed Central: 4381767
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<record><TEI><teiHeader><fileDesc><titleStmt><title xml:lang="en">Tryptophan Catabolism and Vitamin B-6 Status Are Affected by Gender and Lifestyle Factors in Healthy Young Adults<xref ref-type="author-notes" rid="fn1"><sup>1</sup></xref><xref ref-type="author-notes" rid="fn2"><sup>2</sup></xref><xref ref-type="author-notes" rid="fn3"><sup>3</sup></xref></title><author><name sortKey="Deac, Oana M" sort="Deac, Oana M" uniqKey="Deac O" first="Oana M" last="Deac">Oana M. Deac</name><affiliation><nlm:aff wicri:cut=" and" id="aff1">Schools of Medicine</nlm:aff></affiliation></author><author><name sortKey="Mills, James L" sort="Mills, James L" uniqKey="Mills J" first="James L" last="Mills">James L. Mills</name><affiliation><nlm:aff id="aff3">Division of Intramural Population Health Research,<italic>Eunice Kennedy Shriver</italic> National Institute of Child Health and Human Development, NIH, Bethesda, MD;</nlm:aff></affiliation></author><author><name sortKey="Shane, Barry" sort="Shane, Barry" uniqKey="Shane B" first="Barry" last="Shane">Barry Shane</name><affiliation><nlm:aff id="aff4">Nutritional Science and Toxicology, University of California, Berkeley, CA;</nlm:aff></affiliation></author><author><name sortKey="Midttun, Ivind" sort="Midttun, Ivind" uniqKey="Midttun " first=" Ivind" last="Midttun"> Ivind Midttun</name><affiliation><nlm:aff id="aff5">Bevital AS, Bergen, Norway;</nlm:aff></affiliation></author><author><name sortKey="Ueland, Per M" sort="Ueland, Per M" uniqKey="Ueland P" first="Per M" last="Ueland">Per M. Ueland</name><affiliation><nlm:aff id="aff6">Section of Pharmacology, Institute of Medicine, University of Bergen and Haukeland University Hospital, Bergen, Norway;</nlm:aff></affiliation></author><author><name sortKey="Brosnan, John T" sort="Brosnan, John T" uniqKey="Brosnan J" first="John T" last="Brosnan">John T. Brosnan</name><affiliation><nlm:aff id="aff7">Department of Biochemistry, Memorial University, Newfoundland, Canada;</nlm:aff></affiliation></author><author><name sortKey="Brosnan, Margaret E" sort="Brosnan, Margaret E" uniqKey="Brosnan M" first="Margaret E" last="Brosnan">Margaret E. Brosnan</name><affiliation><nlm:aff id="aff7">Department of Biochemistry, Memorial University, Newfoundland, Canada;</nlm:aff></affiliation></author><author><name sortKey="Laird, Eamon" sort="Laird, Eamon" uniqKey="Laird E" first="Eamon" last="Laird">Eamon Laird</name><affiliation><nlm:aff id="aff2">Biochemistry and Immunology, Trinity College Dublin, Dublin, Ireland;</nlm:aff></affiliation></author><author><name sortKey="Gibney, Eileen R" sort="Gibney, Eileen R" uniqKey="Gibney E" first="Eileen R" last="Gibney">Eileen R. Gibney</name><affiliation><nlm:aff wicri:cut="; and" id="aff8">Institute of Food and Health, University College Dublin, Dublin, Ireland</nlm:aff></affiliation></author><author><name sortKey="Fan, Ruzong" sort="Fan, Ruzong" uniqKey="Fan R" first="Ruzong" last="Fan">Ruzong Fan</name><affiliation><nlm:aff id="aff3">Division of Intramural Population Health Research,<italic>Eunice Kennedy Shriver</italic> National Institute of Child Health and Human Development, NIH, Bethesda, MD;</nlm:aff></affiliation></author><author><name sortKey="Wang, Yifan" sort="Wang, Yifan" uniqKey="Wang Y" first="Yifan" last="Wang">Yifan Wang</name><affiliation><nlm:aff id="aff3">Division of Intramural Population Health Research,<italic>Eunice Kennedy Shriver</italic> National Institute of Child Health and Human Development, NIH, Bethesda, MD;</nlm:aff></affiliation></author><author><name sortKey="Brody, Lawrence C" sort="Brody, Lawrence C" uniqKey="Brody L" first="Lawrence C" last="Brody">Lawrence C. Brody</name><affiliation><nlm:aff id="aff9">Molecular Pathogenesis Section, Genome Technology Branch, National Human Genome Research Institute, NIH, Bethesda, MD</nlm:aff></affiliation></author><author><name sortKey="Molloy, Anne M" sort="Molloy, Anne M" uniqKey="Molloy A" first="Anne M" last="Molloy">Anne M. Molloy</name><affiliation><nlm:aff wicri:cut=" and" id="aff1">Schools of Medicine</nlm:aff></affiliation><affiliation><nlm:aff id="aff2">Biochemistry and Immunology, Trinity College Dublin, Dublin, Ireland;</nlm:aff></affiliation></author></titleStmt><publicationStmt><idno type="wicri:source">PMC</idno><idno type="pmid">25833774</idno><idno type="pmc">4381767</idno><idno type="url">http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4381767</idno><idno type="RBID">PMC:4381767</idno><idno type="doi">10.3945/jn.114.203091</idno><date when="2015">2015</date><idno type="wicri:Area/Pmc/Corpus">000594</idno><idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Corpus" wicri:corpus="PMC">000594</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en" level="a" type="main">Tryptophan Catabolism and Vitamin B-6 Status Are Affected by Gender and Lifestyle Factors in Healthy Young Adults<xref ref-type="author-notes" rid="fn1"><sup>1</sup></xref><xref ref-type="author-notes" rid="fn2"><sup>2</sup></xref><xref ref-type="author-notes" rid="fn3"><sup>3</sup></xref></title><author><name sortKey="Deac, Oana M" sort="Deac, Oana M" uniqKey="Deac O" first="Oana M" last="Deac">Oana M. Deac</name><affiliation><nlm:aff wicri:cut=" and" id="aff1">Schools of Medicine</nlm:aff></affiliation></author><author><name sortKey="Mills, James L" sort="Mills, James L" uniqKey="Mills J" first="James L" last="Mills">James L. Mills</name><affiliation><nlm:aff id="aff3">Division of Intramural Population Health Research,<italic>Eunice Kennedy Shriver</italic> National Institute of Child Health and Human Development, NIH, Bethesda, MD;</nlm:aff></affiliation></author><author><name sortKey="Shane, Barry" sort="Shane, Barry" uniqKey="Shane B" first="Barry" last="Shane">Barry Shane</name><affiliation><nlm:aff id="aff4">Nutritional Science and Toxicology, University of California, Berkeley, CA;</nlm:aff></affiliation></author><author><name sortKey="Midttun, Ivind" sort="Midttun, Ivind" uniqKey="Midttun " first=" Ivind" last="Midttun"> Ivind Midttun</name><affiliation><nlm:aff id="aff5">Bevital AS, Bergen, Norway;</nlm:aff></affiliation></author><author><name sortKey="Ueland, Per M" sort="Ueland, Per M" uniqKey="Ueland P" first="Per M" last="Ueland">Per M. Ueland</name><affiliation><nlm:aff id="aff6">Section of Pharmacology, Institute of Medicine, University of Bergen and Haukeland University Hospital, Bergen, Norway;</nlm:aff></affiliation></author><author><name sortKey="Brosnan, John T" sort="Brosnan, John T" uniqKey="Brosnan J" first="John T" last="Brosnan">John T. Brosnan</name><affiliation><nlm:aff id="aff7">Department of Biochemistry, Memorial University, Newfoundland, Canada;</nlm:aff></affiliation></author><author><name sortKey="Brosnan, Margaret E" sort="Brosnan, Margaret E" uniqKey="Brosnan M" first="Margaret E" last="Brosnan">Margaret E. Brosnan</name><affiliation><nlm:aff id="aff7">Department of Biochemistry, Memorial University, Newfoundland, Canada;</nlm:aff></affiliation></author><author><name sortKey="Laird, Eamon" sort="Laird, Eamon" uniqKey="Laird E" first="Eamon" last="Laird">Eamon Laird</name><affiliation><nlm:aff id="aff2">Biochemistry and Immunology, Trinity College Dublin, Dublin, Ireland;</nlm:aff></affiliation></author><author><name sortKey="Gibney, Eileen R" sort="Gibney, Eileen R" uniqKey="Gibney E" first="Eileen R" last="Gibney">Eileen R. Gibney</name><affiliation><nlm:aff wicri:cut="; and" id="aff8">Institute of Food and Health, University College Dublin, Dublin, Ireland</nlm:aff></affiliation></author><author><name sortKey="Fan, Ruzong" sort="Fan, Ruzong" uniqKey="Fan R" first="Ruzong" last="Fan">Ruzong Fan</name><affiliation><nlm:aff id="aff3">Division of Intramural Population Health Research,<italic>Eunice Kennedy Shriver</italic> National Institute of Child Health and Human Development, NIH, Bethesda, MD;</nlm:aff></affiliation></author><author><name sortKey="Wang, Yifan" sort="Wang, Yifan" uniqKey="Wang Y" first="Yifan" last="Wang">Yifan Wang</name><affiliation><nlm:aff id="aff3">Division of Intramural Population Health Research,<italic>Eunice Kennedy Shriver</italic> National Institute of Child Health and Human Development, NIH, Bethesda, MD;</nlm:aff></affiliation></author><author><name sortKey="Brody, Lawrence C" sort="Brody, Lawrence C" uniqKey="Brody L" first="Lawrence C" last="Brody">Lawrence C. Brody</name><affiliation><nlm:aff id="aff9">Molecular Pathogenesis Section, Genome Technology Branch, National Human Genome Research Institute, NIH, Bethesda, MD</nlm:aff></affiliation></author><author><name sortKey="Molloy, Anne M" sort="Molloy, Anne M" uniqKey="Molloy A" first="Anne M" last="Molloy">Anne M. Molloy</name><affiliation><nlm:aff wicri:cut=" and" id="aff1">Schools of Medicine</nlm:aff></affiliation><affiliation><nlm:aff id="aff2">Biochemistry and Immunology, Trinity College Dublin, Dublin, Ireland;</nlm:aff></affiliation></author></analytic><series><title level="j">The Journal of Nutrition</title><idno type="ISSN">0022-3166</idno><idno type="eISSN">1541-6100</idno><imprint><date when="2015">2015</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en"><p><bold>Background:</bold> Abnormalities of tryptophan (Trp) metabolism through the kynurenine (Kyn) pathway have been reported in various diseases; however, nutritional and lifestyle factors that affect this pathway in healthy individuals are not well documented. </p><p><bold>Objective:</bold> Our aim was to examine the effect of vitamin B-6 status and lifestyle factors including the use of vitamin B-6 supplements, alcohol, smoking, and oral contraceptives on Trp and its Kyn metabolites in a cohort of 2436 healthy young adults aged 18–28 y. </p><p><bold>Methods:</bold> Anthropometric and lifestyle data were collected by questionnaire. Participants provided blood samples for analysis of Trp, Kyn, anthranilic acid, kynurenic acid (KA), 3-hydroxykynurenine (HK), 3-hydroxyanthranilic acid (HAA), and xanthurenic acid (XA). Vitamin B-6 species were also measured. </p><p><bold>Results:</bold> Serum Trp metabolites were 10–15% higher among men (<italic>n</italic> = 993) compared with women (<italic>n</italic> = 1443; <italic>P</italic> < 0.0001), except for HK and XA. In all participants, serum Trp was positively associated with plasma pyridoxal 5′-phosphate (PLP; <italic>r</italic> = 0.28, <italic>P</italic> < 0.0001), reaching a plateau at PLP concentrations of ∼83 nmol/L. HK was inversely associated with PLP (<italic>r</italic> = −0.14, <italic>P</italic> < 0.01). Users of vitamin B-6 supplements (<italic>n</italic> = 671) had 6% lower concentrations of HK than nonusers (<italic>n</italic> = 1765; <italic>P</italic> = 0.0006). Oral contraceptive users (<italic>n</italic> = 385) had lower concentrations of KA (20.7%) but higher XA (24.1%) and HAA (9.0%) than did nonusers (<italic>n</italic> = 1058; <italic>P</italic> < 0.0001). After adjustment for gender and other lifestyle variables, XA concentrations were 16% higher in heavy drinkers (<italic>n</italic> = 713) than in never or occasional drinkers (<italic>n</italic> = 975; <italic>P</italic> = 0.0007). Concentrations of 2 other essential amino acids, methionine and arginine, also were positively associated with serum Trp (<italic>r</italic> = 0.65 and 0.33, respectively; <italic>P</italic> < 0.0001). </p><p><bold>Conclusions:</bold> In this population of healthy young adults, gender has the largest influence on serum Kyn metabolite concentrations. The significant covariance of Trp with unrelated amino acids suggests that protein intake may be an important consideration in evaluating Kyn metabolism.</p></div></front></TEI><pmc article-type="research-article"><pmc-comment>The publisher of this article does not allow downloading of the full text in XML form.</pmc-comment>
<front><journal-meta><journal-id journal-id-type="nlm-ta">J Nutr</journal-id><journal-id journal-id-type="publisher-id">nutrition</journal-id><journal-id journal-id-type="hwp">nutrition</journal-id><journal-title-group><journal-title>The Journal of Nutrition</journal-title></journal-title-group><issn pub-type="ppub">0022-3166</issn><issn pub-type="epub">1541-6100</issn><publisher><publisher-name>American Society for Nutrition</publisher-name></publisher></journal-meta><article-meta><article-id pub-id-type="pmid">25833774</article-id><article-id pub-id-type="pmc">4381767</article-id><article-id pub-id-type="publisher-id">203091</article-id><article-id pub-id-type="doi">10.3945/jn.114.203091</article-id><article-categories><subj-group subj-group-type="heading"><subject>Nutrient Physiology, Metabolism, and Nutrient-Nutrient Interactions</subject></subj-group></article-categories><title-group><article-title>Tryptophan Catabolism and Vitamin B-6 Status Are Affected by Gender and Lifestyle Factors in Healthy Young Adults<xref ref-type="author-notes" rid="fn1"><sup>1</sup></xref><xref ref-type="author-notes" rid="fn2"><sup>2</sup></xref><xref ref-type="author-notes" rid="fn3"><sup>3</sup></xref></article-title></title-group><contrib-group><contrib contrib-type="author"><name><surname>Deac</surname><given-names>Oana M</given-names></name><xref ref-type="aff" rid="aff1"><sup>4</sup></xref></contrib><contrib contrib-type="author"><name><surname>Mills</surname><given-names>James L</given-names></name><xref ref-type="aff" rid="aff3"><sup>6</sup></xref></contrib><contrib contrib-type="author"><name><surname>Shane</surname><given-names>Barry</given-names></name><xref ref-type="aff" rid="aff4"><sup>7</sup></xref></contrib><contrib contrib-type="author"><name><surname>Midttun</surname><given-names>Øivind</given-names></name><xref ref-type="aff" rid="aff5"><sup>8</sup></xref></contrib><contrib contrib-type="author"><name><surname>Ueland</surname><given-names>Per M</given-names></name><xref ref-type="aff" rid="aff6"><sup>9</sup></xref></contrib><contrib contrib-type="author"><name><surname>Brosnan</surname><given-names>John T</given-names></name><xref ref-type="aff" rid="aff7"><sup>10</sup></xref></contrib><contrib contrib-type="author"><name><surname>Brosnan</surname><given-names>Margaret E</given-names></name><xref ref-type="aff" rid="aff7"><sup>10</sup></xref></contrib><contrib contrib-type="author"><name><surname>Laird</surname><given-names>Eamon</given-names></name><xref ref-type="aff" rid="aff2"><sup>5</sup></xref></contrib><contrib contrib-type="author"><name><surname>Gibney</surname><given-names>Eileen R</given-names></name><xref ref-type="aff" rid="aff8"><sup>11</sup></xref></contrib><contrib contrib-type="author"><name><surname>Fan</surname><given-names>Ruzong</given-names></name><xref ref-type="aff" rid="aff3"><sup>6</sup></xref></contrib><contrib contrib-type="author"><name><surname>Wang</surname><given-names>Yifan</given-names></name><xref ref-type="aff" rid="aff3"><sup>6</sup></xref></contrib><contrib contrib-type="author"><name><surname>Brody</surname><given-names>Lawrence C</given-names></name><xref ref-type="aff" rid="aff9"><sup>12</sup></xref></contrib><contrib contrib-type="author"><name><surname>Molloy</surname><given-names>Anne M</given-names></name><xref ref-type="aff" rid="aff1"><sup>4</sup></xref><xref ref-type="aff" rid="aff2"><sup>5</sup></xref><xref ref-type="corresp" rid="cor1">*</xref></contrib><aff id="aff1"><label>4</label>Schools of Medicine and</aff><aff id="aff2"><label>5</label>Biochemistry and Immunology, Trinity College Dublin, Dublin, Ireland;</aff><aff id="aff3"><label>6</label>Division of Intramural Population Health Research,<italic>Eunice Kennedy Shriver</italic> National Institute of Child Health and Human Development, NIH, Bethesda, MD;</aff><aff id="aff4"><label>7</label>Nutritional Science and Toxicology, University of California, Berkeley, CA;</aff><aff id="aff5"><label>8</label>Bevital AS, Bergen, Norway;</aff><aff id="aff6"><label>9</label>Section of Pharmacology, Institute of Medicine, University of Bergen and Haukeland University Hospital, Bergen, Norway;</aff><aff id="aff7"><label>10</label>Department of Biochemistry, Memorial University, Newfoundland, Canada;</aff><aff id="aff8"><label>11</label>Institute of Food and Health, University College Dublin, Dublin, Ireland; and</aff><aff id="aff9"><label>12</label>Molecular Pathogenesis Section, Genome Technology Branch, National Human Genome Research Institute, NIH, Bethesda, MD</aff></contrib-group><author-notes><corresp id="cor1"><label>*</label>To whom correspondence should be addressed. E-mail: <email>amolloy@tcd.ie</email>.</corresp><fn id="fn1" fn-type="supported-by"><label>1</label><p>Supported by the Health Research Board, Ireland, and the Intramural Research Program of the <italic>Eunice Kennedy Shriver</italic> National Institute of Child Health and Human Development, NIH, Bethesda, MD (contract N01HD33348).</p></fn><fn id="fn2" fn-type="conflict"><label>2</label><p>Author disclosures: OM Deac, JL Mills, B Shane, Ø Midttun, PM Ueland, JT Brosnan, ME Brosnan, E Laird, ER Gibney, R Fan, Y Wang, LC Brody, and AM Molloy, no conflicts of interest.</p></fn><fn id="fn3"><label>3</label><p>Supplemental Figure 1 and Supplemental Tables 1–3 are available from the “Online Supporting Material” link in the online posting of the article and from the same link in the online table of contents at <ext-link ext-link-type="uri" xlink:href="http://jn.nutrition.org">http://jn.nutrition.org</ext-link>.</p></fn></author-notes><pub-date pub-type="ppub"><month>4</month><year>2015</year></pub-date><pub-date pub-type="epub"><day>18</day><month>2</month><year>2015</year></pub-date><pub-date pub-type="pmc-release"><day>1</day><month>4</month><year>2016</year></pub-date><pmc-comment> PMC Release delay is 12 months and
0 days and was based on the
<volume>145</volume><issue>4</issue><fpage>701</fpage><lpage>707</lpage><history><date date-type="received"><day>4</day><month>9</month><year>2014</year></date><date date-type="rev-recd"><day>16</day><month>10</month><year>2014</year></date><date date-type="accepted"><day>21</day><month>1</month><year>2015</year></date></history><permissions><copyright-statement>© 2015 American Society for Nutrition</copyright-statement><copyright-year>2015</copyright-year></permissions><abstract><p><bold>Background:</bold> Abnormalities of tryptophan (Trp) metabolism through the kynurenine (Kyn) pathway have been reported in various diseases; however, nutritional and lifestyle factors that affect this pathway in healthy individuals are not well documented. </p><p><bold>Objective:</bold> Our aim was to examine the effect of vitamin B-6 status and lifestyle factors including the use of vitamin B-6 supplements, alcohol, smoking, and oral contraceptives on Trp and its Kyn metabolites in a cohort of 2436 healthy young adults aged 18–28 y. </p><p><bold>Methods:</bold> Anthropometric and lifestyle data were collected by questionnaire. Participants provided blood samples for analysis of Trp, Kyn, anthranilic acid, kynurenic acid (KA), 3-hydroxykynurenine (HK), 3-hydroxyanthranilic acid (HAA), and xanthurenic acid (XA). Vitamin B-6 species were also measured. </p><p><bold>Results:</bold> Serum Trp metabolites were 10–15% higher among men (<italic>n</italic> = 993) compared with women (<italic>n</italic> = 1443; <italic>P</italic> < 0.0001), except for HK and XA. In all participants, serum Trp was positively associated with plasma pyridoxal 5′-phosphate (PLP; <italic>r</italic> = 0.28, <italic>P</italic> < 0.0001), reaching a plateau at PLP concentrations of ∼83 nmol/L. HK was inversely associated with PLP (<italic>r</italic> = −0.14, <italic>P</italic> < 0.01). Users of vitamin B-6 supplements (<italic>n</italic> = 671) had 6% lower concentrations of HK than nonusers (<italic>n</italic> = 1765; <italic>P</italic> = 0.0006). Oral contraceptive users (<italic>n</italic> = 385) had lower concentrations of KA (20.7%) but higher XA (24.1%) and HAA (9.0%) than did nonusers (<italic>n</italic> = 1058; <italic>P</italic> < 0.0001). After adjustment for gender and other lifestyle variables, XA concentrations were 16% higher in heavy drinkers (<italic>n</italic> = 713) than in never or occasional drinkers (<italic>n</italic> = 975; <italic>P</italic> = 0.0007). Concentrations of 2 other essential amino acids, methionine and arginine, also were positively associated with serum Trp (<italic>r</italic> = 0.65 and 0.33, respectively; <italic>P</italic> < 0.0001). </p><p><bold>Conclusions:</bold> In this population of healthy young adults, gender has the largest influence on serum Kyn metabolite concentrations. The significant covariance of Trp with unrelated amino acids suggests that protein intake may be an important consideration in evaluating Kyn metabolism.</p></abstract><kwd-group><title>Keywords:</title><kwd>tryptophan</kwd><kwd>kynurenine</kwd><kwd>3-hydroxykynurenine</kwd><kwd>pyridoxal 5′-phosphate</kwd><kwd>vitamin B-6</kwd><kwd>protein</kwd></kwd-group><counts><page-count count="7"></page-count></counts></article-meta></front></pmc></record>Pour manipuler ce document sous Unix (Dilib)
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