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<record><TEI><teiHeader><fileDesc><titleStmt><title xml:lang="en">DJ-1 and αSYN in LRRK2 CSF do not correlate with striatal dopaminergic function</title><author><name sortKey="Shi, Min" sort="Shi, Min" uniqKey="Shi M" first="Min" last="Shi">Min Shi</name><affiliation><nlm:aff id="A1">Department of Pathology, University of Washington School of Medicine, Seattle, WA, USA</nlm:aff></affiliation></author><author><name sortKey="Furay, Amy" sort="Furay, Amy" uniqKey="Furay A" first="Amy" last="Furay">Amy Furay</name><affiliation><nlm:aff id="A1">Department of Pathology, University of Washington School of Medicine, Seattle, WA, USA</nlm:aff></affiliation></author><author><name sortKey="Sossi, Vesna" sort="Sossi, Vesna" uniqKey="Sossi V" first="Vesna" last="Sossi">Vesna Sossi</name><affiliation><nlm:aff id="A2">Department of Physics & Astronomy, University of British Columbia, Vancouver Hospital and Health Sciences Centre, Purdy Pavilion, Vancouver, BC V6T2B5 Canada</nlm:aff></affiliation></author><author><name sortKey="Aasly, Jan O" sort="Aasly, Jan O" uniqKey="Aasly J" first="Jan O." last="Aasly">Jan O. Aasly</name><affiliation><nlm:aff id="A3">Department of Neurology, St. Olavs Hospital, Trondheim, Norway</nlm:aff></affiliation></author><author><name sortKey="Armaly, Jeff" sort="Armaly, Jeff" uniqKey="Armaly J" first="Jeff" last="Armaly">Jeff Armaly</name><affiliation><nlm:aff id="A1">Department of Pathology, University of Washington School of Medicine, Seattle, WA, USA</nlm:aff></affiliation></author><author><name sortKey="Wang, Yu" sort="Wang, Yu" uniqKey="Wang Y" first="Yu" last="Wang">Yu Wang</name><affiliation><nlm:aff id="A1">Department of Pathology, University of Washington School of Medicine, Seattle, WA, USA</nlm:aff></affiliation><affiliation><nlm:aff id="A4">Department of Neurosurgery, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China</nlm:aff></affiliation></author><author><name sortKey="Wszolek, Zbigniew K" sort="Wszolek, Zbigniew K" uniqKey="Wszolek Z" first="Zbigniew K." last="Wszolek">Zbigniew K. Wszolek</name><affiliation><nlm:aff id="A5">Department of Neurology, Mayo Clinic Florida, Jacksonville, FL, USA</nlm:aff></affiliation></author><author><name sortKey="Uitti, Ryan J" sort="Uitti, Ryan J" uniqKey="Uitti R" first="Ryan J." last="Uitti">Ryan J. Uitti</name><affiliation><nlm:aff id="A5">Department of Neurology, Mayo Clinic Florida, Jacksonville, FL, USA</nlm:aff></affiliation></author><author><name sortKey="Hasegawa, Kazuko" sort="Hasegawa, Kazuko" uniqKey="Hasegawa K" first="Kazuko" last="Hasegawa">Kazuko Hasegawa</name><affiliation><nlm:aff id="A6">Department of Neurology, National Hospital Organization, Sagamihara National Hospital, Kanagawa, Japan</nlm:aff></affiliation></author><author><name sortKey="Yokoyama, Teruo" sort="Yokoyama, Teruo" uniqKey="Yokoyama T" first="Teruo" last="Yokoyama">Teruo Yokoyama</name><affiliation><nlm:aff id="A6">Department of Neurology, National Hospital Organization, Sagamihara National Hospital, Kanagawa, Japan</nlm:aff></affiliation></author><author><name sortKey="Zabetian, Cyrus P" sort="Zabetian, Cyrus P" uniqKey="Zabetian C" first="Cyrus P." last="Zabetian">Cyrus P. Zabetian</name><affiliation><nlm:aff id="A7">Geriatric Research, Education, and Clinical Center, Veterans Affairs Puget Sound Health Care System, Seattle, WA, USA</nlm:aff></affiliation><affiliation><nlm:aff id="A8">Parkinson’s Disease Research, Education, and Clinical Center, Veterans Affairs Puget Sound Health Care System, Seattle, WA, USA</nlm:aff></affiliation><affiliation><nlm:aff id="A9">Department of Neurology, University of Washington School of Medicine, Seattle, WA, USA</nlm:aff></affiliation></author><author><name sortKey="Leverenz, James B" sort="Leverenz, James B" uniqKey="Leverenz J" first="James B." last="Leverenz">James B. Leverenz</name><affiliation><nlm:aff id="A8">Parkinson’s Disease Research, Education, and Clinical Center, Veterans Affairs Puget Sound Health Care System, Seattle, WA, USA</nlm:aff></affiliation><affiliation><nlm:aff id="A9">Department of Neurology, University of Washington School of Medicine, Seattle, WA, USA</nlm:aff></affiliation><affiliation><nlm:aff id="A10">Department of Psychiatry and Behavioral Sciences, University of Washington School of Medicine, Seattle, WA, USA</nlm:aff></affiliation><affiliation><nlm:aff id="A11">Mental Illness Research, Education, and Clinical Center, Veterans Affairs Puget Sound Health Care System, Seattle, WA, USA</nlm:aff></affiliation></author><author><name sortKey="Stoessl, A Jon" sort="Stoessl, A Jon" uniqKey="Stoessl A" first="A. Jon" last="Stoessl">A. Jon Stoessl</name><affiliation><nlm:aff id="A12">Pacific Parkinson’s Research Centre, University of British Columbia & Vancouver Coastal Health, Vancouver, BC V6T2B5 Canada</nlm:aff></affiliation></author><author><name sortKey="Zhang, Jing" sort="Zhang, Jing" uniqKey="Zhang J" first="Jing" last="Zhang">Jing Zhang</name><affiliation><nlm:aff id="A1">Department of Pathology, University of Washington School of Medicine, Seattle, WA, USA</nlm:aff></affiliation></author></titleStmt><publicationStmt><idno type="wicri:source">PMC</idno><idno type="pmid">22019052</idno><idno type="pmc">3279603</idno><idno type="url">http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3279603</idno><idno type="RBID">PMC:3279603</idno><idno type="doi">10.1016/j.neurobiolaging.2011.09.015</idno><date when="2011">2011</date><idno type="wicri:Area/Pmc/Corpus">000474</idno><idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Corpus" wicri:corpus="PMC">000474</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en" level="a" type="main">DJ-1 and αSYN in LRRK2 CSF do not correlate with striatal dopaminergic function</title><author><name sortKey="Shi, Min" sort="Shi, Min" uniqKey="Shi M" first="Min" last="Shi">Min Shi</name><affiliation><nlm:aff id="A1">Department of Pathology, University of Washington School of Medicine, Seattle, WA, USA</nlm:aff></affiliation></author><author><name sortKey="Furay, Amy" sort="Furay, Amy" uniqKey="Furay A" first="Amy" last="Furay">Amy Furay</name><affiliation><nlm:aff id="A1">Department of Pathology, University of Washington School of Medicine, Seattle, WA, USA</nlm:aff></affiliation></author><author><name sortKey="Sossi, Vesna" sort="Sossi, Vesna" uniqKey="Sossi V" first="Vesna" last="Sossi">Vesna Sossi</name><affiliation><nlm:aff id="A2">Department of Physics & Astronomy, University of British Columbia, Vancouver Hospital and Health Sciences Centre, Purdy Pavilion, Vancouver, BC V6T2B5 Canada</nlm:aff></affiliation></author><author><name sortKey="Aasly, Jan O" sort="Aasly, Jan O" uniqKey="Aasly J" first="Jan O." last="Aasly">Jan O. Aasly</name><affiliation><nlm:aff id="A3">Department of Neurology, St. Olavs Hospital, Trondheim, Norway</nlm:aff></affiliation></author><author><name sortKey="Armaly, Jeff" sort="Armaly, Jeff" uniqKey="Armaly J" first="Jeff" last="Armaly">Jeff Armaly</name><affiliation><nlm:aff id="A1">Department of Pathology, University of Washington School of Medicine, Seattle, WA, USA</nlm:aff></affiliation></author><author><name sortKey="Wang, Yu" sort="Wang, Yu" uniqKey="Wang Y" first="Yu" last="Wang">Yu Wang</name><affiliation><nlm:aff id="A1">Department of Pathology, University of Washington School of Medicine, Seattle, WA, USA</nlm:aff></affiliation><affiliation><nlm:aff id="A4">Department of Neurosurgery, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China</nlm:aff></affiliation></author><author><name sortKey="Wszolek, Zbigniew K" sort="Wszolek, Zbigniew K" uniqKey="Wszolek Z" first="Zbigniew K." last="Wszolek">Zbigniew K. Wszolek</name><affiliation><nlm:aff id="A5">Department of Neurology, Mayo Clinic Florida, Jacksonville, FL, USA</nlm:aff></affiliation></author><author><name sortKey="Uitti, Ryan J" sort="Uitti, Ryan J" uniqKey="Uitti R" first="Ryan J." last="Uitti">Ryan J. Uitti</name><affiliation><nlm:aff id="A5">Department of Neurology, Mayo Clinic Florida, Jacksonville, FL, USA</nlm:aff></affiliation></author><author><name sortKey="Hasegawa, Kazuko" sort="Hasegawa, Kazuko" uniqKey="Hasegawa K" first="Kazuko" last="Hasegawa">Kazuko Hasegawa</name><affiliation><nlm:aff id="A6">Department of Neurology, National Hospital Organization, Sagamihara National Hospital, Kanagawa, Japan</nlm:aff></affiliation></author><author><name sortKey="Yokoyama, Teruo" sort="Yokoyama, Teruo" uniqKey="Yokoyama T" first="Teruo" last="Yokoyama">Teruo Yokoyama</name><affiliation><nlm:aff id="A6">Department of Neurology, National Hospital Organization, Sagamihara National Hospital, Kanagawa, Japan</nlm:aff></affiliation></author><author><name sortKey="Zabetian, Cyrus P" sort="Zabetian, Cyrus P" uniqKey="Zabetian C" first="Cyrus P." last="Zabetian">Cyrus P. Zabetian</name><affiliation><nlm:aff id="A7">Geriatric Research, Education, and Clinical Center, Veterans Affairs Puget Sound Health Care System, Seattle, WA, USA</nlm:aff></affiliation><affiliation><nlm:aff id="A8">Parkinson’s Disease Research, Education, and Clinical Center, Veterans Affairs Puget Sound Health Care System, Seattle, WA, USA</nlm:aff></affiliation><affiliation><nlm:aff id="A9">Department of Neurology, University of Washington School of Medicine, Seattle, WA, USA</nlm:aff></affiliation></author><author><name sortKey="Leverenz, James B" sort="Leverenz, James B" uniqKey="Leverenz J" first="James B." last="Leverenz">James B. Leverenz</name><affiliation><nlm:aff id="A8">Parkinson’s Disease Research, Education, and Clinical Center, Veterans Affairs Puget Sound Health Care System, Seattle, WA, USA</nlm:aff></affiliation><affiliation><nlm:aff id="A9">Department of Neurology, University of Washington School of Medicine, Seattle, WA, USA</nlm:aff></affiliation><affiliation><nlm:aff id="A10">Department of Psychiatry and Behavioral Sciences, University of Washington School of Medicine, Seattle, WA, USA</nlm:aff></affiliation><affiliation><nlm:aff id="A11">Mental Illness Research, Education, and Clinical Center, Veterans Affairs Puget Sound Health Care System, Seattle, WA, USA</nlm:aff></affiliation></author><author><name sortKey="Stoessl, A Jon" sort="Stoessl, A Jon" uniqKey="Stoessl A" first="A. Jon" last="Stoessl">A. Jon Stoessl</name><affiliation><nlm:aff id="A12">Pacific Parkinson’s Research Centre, University of British Columbia & Vancouver Coastal Health, Vancouver, BC V6T2B5 Canada</nlm:aff></affiliation></author><author><name sortKey="Zhang, Jing" sort="Zhang, Jing" uniqKey="Zhang J" first="Jing" last="Zhang">Jing Zhang</name><affiliation><nlm:aff id="A1">Department of Pathology, University of Washington School of Medicine, Seattle, WA, USA</nlm:aff></affiliation></author></analytic><series><title level="j">Neurobiology of Aging</title><idno type="ISSN">0197-4580</idno><idno type="eISSN">1558-1497</idno><imprint><date when="2011">2011</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en"><p id="P2">Previous studies demonstrated decreased levels of DJ-1 and α-synuclein (αSYN) in human cerebrospinal fluid (CSF) in patients with Parkinson’s disease (PD), but neither marker correlated with PD severity, raising the possibility that they may be excellent progression markers during early or preclinical phases of PD. Individuals carrying the leucine-rich repeat kinase 2 (LRRK2) gene mutation are at increased risk for PD, and the phenotype of LRRK2 patients is almost identical to sporadic PD. To determine whether dopaminergic dysfunction in the basal ganglia, as determined by positron emission tomography (PET) scans, correlates with CSF levels of DJ-1 and αSYN during preclinical stages, Luminex assays were used to analyze CSF samples from asymptomatic LRRK2 mutation carriers, along with carriers who presented with a clinical diagnosis of PD. The data revealed no statistically significant relationship between PET scan evidence of loss of striatal dopaminergic function and the CSF biomarkers DJ-1 and αSYN, except for a weak correlation between DJ-1 and MP binding, suggesting that the use of these potential biomarkers on their own to screen LRRK2 gene mutation carriers for PD is not appropriate.</p></div></front></TEI><pmc article-type="research-article" xml:lang="en"><pmc-comment>The publisher of this article does not allow downloading of the full text in XML form.</pmc-comment>
<pmc-dir>properties manuscript</pmc-dir>
<front><journal-meta><journal-id journal-id-type="nlm-journal-id">8100437</journal-id><journal-id journal-id-type="pubmed-jr-id">6047</journal-id><journal-id journal-id-type="nlm-ta">Neurobiol Aging</journal-id><journal-title-group><journal-title>Neurobiology of Aging</journal-title></journal-title-group><issn pub-type="ppub">0197-4580</issn><issn pub-type="epub">1558-1497</issn></journal-meta><article-meta><article-id pub-id-type="pmid">22019052</article-id><article-id pub-id-type="pmc">3279603</article-id><article-id pub-id-type="doi">10.1016/j.neurobiolaging.2011.09.015</article-id><article-id pub-id-type="manuscript">NIHMS334807</article-id><article-categories><subj-group subj-group-type="heading"><subject>Article</subject></subj-group></article-categories><title-group><article-title>DJ-1 and αSYN in LRRK2 CSF do not correlate with striatal dopaminergic function</article-title></title-group><contrib-group><contrib contrib-type="author"><name><surname>Shi</surname><given-names>Min</given-names></name><xref rid="A1" ref-type="aff">a</xref><xref rid="FN2" ref-type="author-notes">*</xref></contrib><contrib contrib-type="author"><name><surname>Furay</surname><given-names>Amy</given-names></name><xref rid="A1" ref-type="aff">a</xref><xref rid="FN2" ref-type="author-notes">*</xref></contrib><contrib contrib-type="author"><name><surname>Sossi</surname><given-names>Vesna</given-names></name><xref rid="A2" ref-type="aff">b</xref></contrib><contrib contrib-type="author"><name><surname>Aasly</surname><given-names>Jan O.</given-names></name><xref rid="A3" ref-type="aff">c</xref></contrib><contrib contrib-type="author"><name><surname>Armaly</surname><given-names>Jeff</given-names></name><xref rid="A1" ref-type="aff">a</xref></contrib><contrib contrib-type="author"><name><surname>Wang</surname><given-names>Yu</given-names></name><xref rid="A1" ref-type="aff">a</xref><xref rid="A4" ref-type="aff">d</xref></contrib><contrib contrib-type="author"><name><surname>Wszolek</surname><given-names>Zbigniew K.</given-names></name><xref rid="A5" ref-type="aff">e</xref></contrib><contrib contrib-type="author"><name><surname>Uitti</surname><given-names>Ryan J.</given-names></name><xref rid="A5" ref-type="aff">e</xref></contrib><contrib contrib-type="author"><name><surname>Hasegawa</surname><given-names>Kazuko</given-names></name><xref rid="A6" ref-type="aff">f</xref></contrib><contrib contrib-type="author"><name><surname>Yokoyama</surname><given-names>Teruo</given-names></name><xref rid="A6" ref-type="aff">f</xref></contrib><contrib contrib-type="author"><name><surname>Zabetian</surname><given-names>Cyrus P.</given-names></name><xref rid="A7" ref-type="aff">g</xref><xref rid="A8" ref-type="aff">h</xref><xref rid="A9" ref-type="aff">i</xref></contrib><contrib contrib-type="author"><name><surname>Leverenz</surname><given-names>James B.</given-names></name><xref rid="A8" ref-type="aff">h</xref><xref rid="A9" ref-type="aff">i</xref><xref rid="A10" ref-type="aff">j</xref><xref rid="A11" ref-type="aff">k</xref></contrib><contrib contrib-type="author"><name><surname>Stoessl</surname><given-names>A. Jon</given-names></name><xref rid="A12" ref-type="aff">l</xref></contrib><contrib contrib-type="author"><name><surname>Zhang</surname><given-names>Jing</given-names></name><xref rid="A1" ref-type="aff">a</xref><xref rid="FN1" ref-type="author-notes">†</xref></contrib></contrib-group><aff id="A1"><label>a</label>Department of Pathology, University of Washington School of Medicine, Seattle, WA, USA</aff><aff id="A2"><label>b</label>Department of Physics & Astronomy, University of British Columbia, Vancouver Hospital and Health Sciences Centre, Purdy Pavilion, Vancouver, BC V6T2B5 Canada</aff><aff id="A3"><label>c</label>Department of Neurology, St. Olavs Hospital, Trondheim, Norway</aff><aff id="A4"><label>d</label>Department of Neurosurgery, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China</aff><aff id="A5"><label>e</label>Department of Neurology, Mayo Clinic Florida, Jacksonville, FL, USA</aff><aff id="A6"><label>f</label>Department of Neurology, National Hospital Organization, Sagamihara National Hospital, Kanagawa, Japan</aff><aff id="A7"><label>g</label>Geriatric Research, Education, and Clinical Center, Veterans Affairs Puget Sound Health Care System, Seattle, WA, USA</aff><aff id="A8"><label>h</label>Parkinson’s Disease Research, Education, and Clinical Center, Veterans Affairs Puget Sound Health Care System, Seattle, WA, USA</aff><aff id="A9"><label>i</label>Department of Neurology, University of Washington School of Medicine, Seattle, WA, USA</aff><aff id="A10"><label>j</label>Department of Psychiatry and Behavioral Sciences, University of Washington School of Medicine, Seattle, WA, USA</aff><aff id="A11"><label>k</label>Mental Illness Research, Education, and Clinical Center, Veterans Affairs Puget Sound Health Care System, Seattle, WA, USA</aff><aff id="A12"><label>l</label>Pacific Parkinson’s Research Centre, University of British Columbia & Vancouver Coastal Health, Vancouver, BC V6T2B5 Canada</aff><author-notes><corresp id="FN1"><label>†</label>Address correspondence to: Jing Zhang, Department of Pathology, University of Washington School of Medicine, HMC Box 359635, 325 9<sup>th</sup> Ave, Seattle, WA 98104, USA. Phone: 1-206-897-5245, Fax: 1-206-897-5452, <email>zhangj@uw.edu</email></corresp><fn id="FN2" fn-type="equal"><label>*</label><p>The authors have contributed equally.</p></fn></author-notes><pub-date pub-type="nihms-submitted"><day>7</day><month>11</month><year>2011</year></pub-date><pub-date pub-type="epub"><day>21</day><month>10</month><year>2011</year></pub-date><pub-date pub-type="ppub"><month>4</month><year>2012</year></pub-date><pub-date pub-type="pmc-release"><day>1</day><month>4</month><year>2013</year></pub-date><volume>33</volume><issue>4</issue><fpage>836.e5</fpage><lpage>836.e7</lpage><permissions><copyright-statement>© 2011 Elsevier Inc. All rights reserved.</copyright-statement><copyright-year>2011</copyright-year></permissions><abstract><p id="P2">Previous studies demonstrated decreased levels of DJ-1 and α-synuclein (αSYN) in human cerebrospinal fluid (CSF) in patients with Parkinson’s disease (PD), but neither marker correlated with PD severity, raising the possibility that they may be excellent progression markers during early or preclinical phases of PD. Individuals carrying the leucine-rich repeat kinase 2 (LRRK2) gene mutation are at increased risk for PD, and the phenotype of LRRK2 patients is almost identical to sporadic PD. To determine whether dopaminergic dysfunction in the basal ganglia, as determined by positron emission tomography (PET) scans, correlates with CSF levels of DJ-1 and αSYN during preclinical stages, Luminex assays were used to analyze CSF samples from asymptomatic LRRK2 mutation carriers, along with carriers who presented with a clinical diagnosis of PD. The data revealed no statistically significant relationship between PET scan evidence of loss of striatal dopaminergic function and the CSF biomarkers DJ-1 and αSYN, except for a weak correlation between DJ-1 and MP binding, suggesting that the use of these potential biomarkers on their own to screen LRRK2 gene mutation carriers for PD is not appropriate.</p></abstract><kwd-group><kwd>Parkinson’s Disease</kwd><kwd>LRRK2</kwd><kwd>gene mutation</kwd><kwd>biomarker</kwd><kwd>DJ-1</kwd><kwd>α-synuclein</kwd></kwd-group><funding-group><award-group><funding-source country="United States">National Institute of Environmental Health Sciences : NIEHS</funding-source><award-id>R01 ES019277-01A1 || ES</award-id></award-group><award-group><funding-source country="United States">National Institute of Environmental Health Sciences : NIEHS</funding-source><award-id>R01 ES016873-03 || ES</award-id></award-group><award-group><funding-source country="United States">National Institute on Aging : NIA</funding-source><award-id>R01 AG033398-05 || AG</award-id></award-group></funding-group></article-meta></front></pmc></record>Pour manipuler ce document sous Unix (Dilib)
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