Walking in circles: navigation deficits from Parkinson's disease but not from cerebellar ataxia
Identifieur interne : 000470 ( Pmc/Corpus ); précédent : 000469; suivant : 000471Walking in circles: navigation deficits from Parkinson's disease but not from cerebellar ataxia
Auteurs : Caroline Paquette ; Erika Franzén ; Geoffrey Melvill Jones ; Fay B. HorakSource :
- Neuroscience [ 0306-4522 ] ; 2011.
Abstract
Little is known on the role of neuronal structures for spatial navigation. Our goal was to examine how Parkinson's disease (PD) and cerebellar ataxia, as human lesion models of the basal ganglia and cerebellum, affect spatial navigation round a circular walking path, blindfolded. Twelve subjects with idiopathic PD (ON and OFF medication), 8 subjects with cerebellar ataxia and a control group of 20 age-matched healthy subjects participated. All groups performed well when walking around the circle with eyes open. In the eyes-closed condition, control subjects overshot the outlined trajectory but returned to their initial position, thus walking a further distance with eyes closed than with eyes open. When OFF medication, PD subjects navigated a larger radius than controls with eyes closed. When ON levodopa, PD subjects walked a similar distance as controls but with even larger errors in endpoint. Surprisingly, cerebellar patients navigated the circular walking task in the eyes closed condition with even more accuracy (i.e. following the outlined circle) than control and PD subjects. We conclude that blindfolded navigation around a previously seen circle requires intact basal ganglia, but not cerebellar input.
Url:
DOI: 10.1016/j.neuroscience.2011.06.020
PubMed: 21704129
PubMed Central: 3156363
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PMC:3156363Le document en format XML
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<author><name sortKey="Paquette, Caroline" sort="Paquette, Caroline" uniqKey="Paquette C" first="Caroline" last="Paquette">Caroline Paquette</name>
<affiliation><nlm:aff id="A1"> Department of Neurology, Oregon Health & Science University, Portland, Oregon, USA, 505 NW 185 Avenue, Beaverton, OR 97006 USA</nlm:aff>
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<author><name sortKey="Franzen, Erika" sort="Franzen, Erika" uniqKey="Franzen E" first="Erika" last="Franzén">Erika Franzén</name>
<affiliation><nlm:aff id="A1"> Department of Neurology, Oregon Health & Science University, Portland, Oregon, USA, 505 NW 185 Avenue, Beaverton, OR 97006 USA</nlm:aff>
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<affiliation><nlm:aff id="A2"> Department of Neurobiology, Care Sciences and Society, Karolinska Institutet and Department of Physical Therapy, Karolinska University Hospital, Stockholm, Sweden, Institutionen for Neurobiologi, Vardvetenskap och Samhalle (NVS), Sektionen for sjukgymnastik, 23 100, 141 83 HUDDINGE Sweden</nlm:aff>
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<author><name sortKey="Jones, Geoffrey Melvill" sort="Jones, Geoffrey Melvill" uniqKey="Jones G" first="Geoffrey Melvill" last="Jones">Geoffrey Melvill Jones</name>
<affiliation><nlm:aff id="A3"> Department of clinical Neurosciences, University of Calgary, Alberta, Canada, Heritage Medical Research Building, University of Calgary, 3330 Hospital Drive N.W., Calgary AB, T2N 4N1 Canada</nlm:aff>
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<author><name sortKey="Horak, Fay B" sort="Horak, Fay B" uniqKey="Horak F" first="Fay B" last="Horak">Fay B. Horak</name>
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<series><title level="j">Neuroscience</title>
<idno type="ISSN">0306-4522</idno>
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<front><div type="abstract" xml:lang="en"><p id="P1">Little is known on the role of neuronal structures for spatial navigation. Our goal was to examine how Parkinson's disease (PD) and cerebellar ataxia, as human lesion models of the basal ganglia and cerebellum, affect spatial navigation round a circular walking path, blindfolded. Twelve subjects with idiopathic PD (ON and OFF medication), 8 subjects with cerebellar ataxia and a control group of 20 age-matched healthy subjects participated. All groups performed well when walking around the circle with eyes open. In the eyes-closed condition, control subjects overshot the outlined trajectory but returned to their initial position, thus walking a further distance with eyes closed than with eyes open. When OFF medication, PD subjects navigated a larger radius than controls with eyes closed. When ON levodopa, PD subjects walked a similar distance as controls but with even larger errors in endpoint. Surprisingly, cerebellar patients navigated the circular walking task in the eyes closed condition with even more accuracy (i.e. following the outlined circle) than control and PD subjects. We conclude that blindfolded navigation around a previously seen circle requires intact basal ganglia, but not cerebellar input.</p>
</div>
</front>
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<front><journal-meta><journal-id journal-id-type="nlm-journal-id">7605074</journal-id>
<journal-id journal-id-type="pubmed-jr-id">6087</journal-id>
<journal-id journal-id-type="nlm-ta">Neuroscience</journal-id>
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<article-categories><subj-group subj-group-type="heading"><subject>Article</subject>
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<title-group><article-title>Walking in circles: navigation deficits from Parkinson's disease but not from cerebellar ataxia</article-title>
</title-group>
<contrib-group><contrib contrib-type="author"><name><surname>Paquette</surname>
<given-names>Caroline</given-names>
</name>
<xref rid="A1" ref-type="aff">a</xref>
<xref rid="FN2" ref-type="author-notes">1</xref>
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<contrib contrib-type="author"><name><surname>Franzén</surname>
<given-names>Erika</given-names>
</name>
<xref rid="A1" ref-type="aff">a</xref>
<xref rid="A2" ref-type="aff">b</xref>
<email>erika.franzen@ki.se</email>
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<contrib contrib-type="author"><name><surname>Jones</surname>
<given-names>Geoffrey Melvill</given-names>
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<xref rid="A3" ref-type="aff">c</xref>
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<contrib contrib-type="author"><name><surname>Horak</surname>
<given-names>Fay B</given-names>
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<xref rid="A1" ref-type="aff">a</xref>
<email>horakf@ohsu.edu</email>
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<aff id="A1"><label>a</label>
Department of Neurology, Oregon Health & Science University, Portland, Oregon, USA, 505 NW 185 Avenue, Beaverton, OR 97006 USA</aff>
<aff id="A2"><label>b</label>
Department of Neurobiology, Care Sciences and Society, Karolinska Institutet and Department of Physical Therapy, Karolinska University Hospital, Stockholm, Sweden, Institutionen for Neurobiologi, Vardvetenskap och Samhalle (NVS), Sektionen for sjukgymnastik, 23 100, 141 83 HUDDINGE Sweden</aff>
<aff id="A3"><label>c</label>
Department of clinical Neurosciences, University of Calgary, Alberta, Canada, Heritage Medical Research Building, University of Calgary, 3330 Hospital Drive N.W., Calgary AB, T2N 4N1 Canada</aff>
<author-notes><corresp id="FN1">Corresponding author: Caroline Paquette (<email>caroline.paquette@mail.mcgill.ca</email>
), Neuroplasticity Laboratory, Department of Neurology, McGill University at SMBD-Jewish General Hospital & Lady Davis Institute, 3755 Cote Ste-Catherine Road, Room E224.1, Montreal, Quebec H3T 1E2 Canada, ph: 1-514-340-8222 x.4311, fax: 1-514-340-7922</corresp>
<fn id="FN2" fn-type="present-address"><label>1</label>
<p>Present Address: Neuroplasticity Laboratory, Department of Neurology & Neurosurgery, McGill University at SMBD-Jewish General Hospital & Lady Davis Institute, Montreal, Quebec, Canada</p>
</fn>
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<pub-date pub-type="nihms-submitted"><day>21</day>
<month>6</month>
<year>2011</year>
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<pub-date pub-type="epub"><day>14</day>
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<year>2011</year>
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<pub-date pub-type="ppub"><day>8</day>
<month>9</month>
<year>2011</year>
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<pub-date pub-type="pmc-release"><day>8</day>
<month>9</month>
<year>2012</year>
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<volume>190</volume>
<fpage>177</fpage>
<lpage>183</lpage>
<permissions><copyright-statement>© 2011 IBRO. Published by Elsevier Ltd. All rights reserved.</copyright-statement>
<copyright-year>2011</copyright-year>
</permissions>
<abstract><p id="P1">Little is known on the role of neuronal structures for spatial navigation. Our goal was to examine how Parkinson's disease (PD) and cerebellar ataxia, as human lesion models of the basal ganglia and cerebellum, affect spatial navigation round a circular walking path, blindfolded. Twelve subjects with idiopathic PD (ON and OFF medication), 8 subjects with cerebellar ataxia and a control group of 20 age-matched healthy subjects participated. All groups performed well when walking around the circle with eyes open. In the eyes-closed condition, control subjects overshot the outlined trajectory but returned to their initial position, thus walking a further distance with eyes closed than with eyes open. When OFF medication, PD subjects navigated a larger radius than controls with eyes closed. When ON levodopa, PD subjects walked a similar distance as controls but with even larger errors in endpoint. Surprisingly, cerebellar patients navigated the circular walking task in the eyes closed condition with even more accuracy (i.e. following the outlined circle) than control and PD subjects. We conclude that blindfolded navigation around a previously seen circle requires intact basal ganglia, but not cerebellar input.</p>
</abstract>
<kwd-group><kwd>Levodopa</kwd>
<kwd>Kinematics</kwd>
<kwd>Task Performance and Analysis</kwd>
<kwd>Gait</kwd>
<kwd>Navigation</kwd>
</kwd-group>
<funding-group><award-group><funding-source country="United States">National Institute on Aging : NIA</funding-source>
<award-id>R37 AG006457-24 || AG</award-id>
</award-group>
<award-group><funding-source country="United States">National Institute on Deafness and Other Communication Disorders : NIDCD</funding-source>
<award-id>R01 DC004082-09 || DC</award-id>
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