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<record><TEI><teiHeader><fileDesc><titleStmt><title xml:lang="en">Shaping plasticity to enhance recovery after injury</title>
<author><name sortKey="Dancause, Numa" sort="Dancause, Numa" uniqKey="Dancause N" first="Numa" last="Dancause">Numa Dancause</name>
<affiliation><nlm:aff id="A1">Département de Physiologie, Université de Montréal, Chemin de la Tour Montréal, Québec, Canada</nlm:aff>
</affiliation>
</author>
<author><name sortKey="Nudo, Randolph J" sort="Nudo, Randolph J" uniqKey="Nudo R" first="Randolph J." last="Nudo">Randolph J. Nudo</name>
<affiliation><nlm:aff id="A2">Landon Center on Aging, Kansas University Medical Center, Kansas City, Kansas, USA</nlm:aff>
</affiliation>
</author>
</titleStmt>
<publicationStmt><idno type="wicri:source">PMC</idno>
<idno type="pmid">21763529</idno>
<idno type="pmc">3245976</idno>
<idno type="url">http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3245976</idno>
<idno type="RBID">PMC:3245976</idno>
<idno type="doi">10.1016/B978-0-444-53355-5.00015-4</idno>
<date when="2011">2011</date>
<idno type="wicri:Area/Pmc/Corpus">000466</idno>
<idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Corpus" wicri:corpus="PMC">000466</idno>
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<sourceDesc><biblStruct><analytic><title xml:lang="en" level="a" type="main">Shaping plasticity to enhance recovery after injury</title>
<author><name sortKey="Dancause, Numa" sort="Dancause, Numa" uniqKey="Dancause N" first="Numa" last="Dancause">Numa Dancause</name>
<affiliation><nlm:aff id="A1">Département de Physiologie, Université de Montréal, Chemin de la Tour Montréal, Québec, Canada</nlm:aff>
</affiliation>
</author>
<author><name sortKey="Nudo, Randolph J" sort="Nudo, Randolph J" uniqKey="Nudo R" first="Randolph J." last="Nudo">Randolph J. Nudo</name>
<affiliation><nlm:aff id="A2">Landon Center on Aging, Kansas University Medical Center, Kansas City, Kansas, USA</nlm:aff>
</affiliation>
</author>
</analytic>
<series><title level="j">Progress in brain research</title>
<idno type="ISSN">0079-6123</idno>
<idno type="eISSN">1875-7855</idno>
<imprint><date when="2011">2011</date>
</imprint>
</series>
</biblStruct>
</sourceDesc>
</fileDesc>
<profileDesc><textClass></textClass>
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</teiHeader>
<front><div type="abstract" xml:lang="en"><p id="P1">The past decade of neuroscience research has provided considerable evidence that the adult brain can undergo substantial reorganization following injury. For example, following an ischemic lesion, such as occurs following a stroke, there is a cascade of molecular, genetic, physiological and anatomical events that allows the remaining structures in the brain to reorganize. Often, these events are associated with recovery, suggesting that they contribute to it. Indeed, the term plasticity in stroke research has had a positive connotation historically. But more recently, efforts have been made to differentiate beneficial from detrimental changes. These notions are timely now that neurorehabilitative research is developing novel treatments to modulate, increase, or inhibit plasticity in targeted brain regions. We will review basic principles of plasticity and some of the new and exciting approaches that are currently being investigated to shape plasticity following injury in the central nervous system.</p>
</div>
</front>
</TEI>
<pmc article-type="research-article" xml:lang="en"><pmc-comment>The publisher of this article does not allow downloading of the full text in XML form.</pmc-comment>
<pmc-dir>properties manuscript</pmc-dir>
<front><journal-meta><journal-id journal-id-type="nlm-journal-id">0376441</journal-id>
<journal-id journal-id-type="pubmed-jr-id">6691</journal-id>
<journal-id journal-id-type="nlm-ta">Prog Brain Res</journal-id>
<journal-title-group><journal-title>Progress in brain research</journal-title>
</journal-title-group>
<issn pub-type="ppub">0079-6123</issn>
<issn pub-type="epub">1875-7855</issn>
</journal-meta>
<article-meta><article-id pub-id-type="pmid">21763529</article-id>
<article-id pub-id-type="pmc">3245976</article-id>
<article-id pub-id-type="doi">10.1016/B978-0-444-53355-5.00015-4</article-id>
<article-id pub-id-type="manuscript">NIHMS340726</article-id>
<article-categories><subj-group subj-group-type="heading"><subject>Article</subject>
</subj-group>
</article-categories>
<title-group><article-title>Shaping plasticity to enhance recovery after injury</article-title>
</title-group>
<contrib-group><contrib contrib-type="author"><name><surname>Dancause</surname>
<given-names>Numa</given-names>
</name>
<xref ref-type="aff" rid="A1">†</xref>
<xref ref-type="corresp" rid="cor1">*</xref>
</contrib>
<contrib contrib-type="author"><name><surname>Nudo</surname>
<given-names>Randolph J.</given-names>
</name>
<xref ref-type="aff" rid="A2">‡</xref>
</contrib>
</contrib-group>
<aff id="A1"><label>†</label>
Département de Physiologie, Université de Montréal, Chemin de la Tour Montréal, Québec, Canada</aff>
<aff id="A2"><label>‡</label>
Landon Center on Aging, Kansas University Medical Center, Kansas City, Kansas, USA</aff>
<author-notes><corresp id="cor1"><label>*</label>
Corresponding author. Phone : (514) 343-6317 Fax: (514) 343-6113 <email>numa.dancause@umontreal.ca</email>
</corresp>
</author-notes>
<pub-date pub-type="nihms-submitted"><day>28</day>
<month>11</month>
<year>2011</year>
</pub-date>
<pub-date pub-type="ppub"><year>2011</year>
</pub-date>
<pub-date pub-type="pmc-release"><day>1</day>
<month>1</month>
<year>2012</year>
</pub-date>
<volume>192</volume>
<fpage>273</fpage>
<lpage>295</lpage>
<permissions><copyright-statement>Copyright © 2011 Elsevier B.V. All rights reserved.</copyright-statement>
<copyright-year>2011</copyright-year>
</permissions>
<abstract><p id="P1">The past decade of neuroscience research has provided considerable evidence that the adult brain can undergo substantial reorganization following injury. For example, following an ischemic lesion, such as occurs following a stroke, there is a cascade of molecular, genetic, physiological and anatomical events that allows the remaining structures in the brain to reorganize. Often, these events are associated with recovery, suggesting that they contribute to it. Indeed, the term plasticity in stroke research has had a positive connotation historically. But more recently, efforts have been made to differentiate beneficial from detrimental changes. These notions are timely now that neurorehabilitative research is developing novel treatments to modulate, increase, or inhibit plasticity in targeted brain regions. We will review basic principles of plasticity and some of the new and exciting approaches that are currently being investigated to shape plasticity following injury in the central nervous system.</p>
</abstract>
<kwd-group><kwd>Cortex</kwd>
<kwd>Stimulation</kwd>
<kwd>Plasticity</kwd>
<kwd>Recovery</kwd>
<kwd>Rehabilitation</kwd>
<kwd>Stroke</kwd>
</kwd-group>
<funding-group><award-group><funding-source country="United States">National Institute of Neurological Disorders and Stroke : NINDS</funding-source>
<award-id>R37 NS030853-18 || NS</award-id>
</award-group>
</funding-group>
</article-meta>
</front>
</pmc>
</record>
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