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<record><TEI><teiHeader><fileDesc><titleStmt><title xml:lang="en">Dopamine neurons implanted into people with Parkinson’s disease survive without pathology for 14 years</title><author><name sortKey="Mendez, Ivar" sort="Mendez, Ivar" uniqKey="Mendez I" first="Ivar" last="Mendez">Ivar Mendez</name><affiliation><nlm:aff id="A1">Dalhousie University and Queen Elizabeth II Health Sciences Centre, Division of Neurosurgery and Departments of Anatomy & Neurobiology and Pharmacology, 1976 Summer Street, Halifax, Nova Scotia B3H 3A7, Canada.</nlm:aff></affiliation></author><author><name sortKey="Vi Uela, Angel" sort="Vi Uela, Angel" uniqKey="Vi Uela A" first="Angel" last="Vi Uela">Angel Vi Uela</name><affiliation><nlm:aff id="A2">Harvard University and McLean Hospital, US National Institute of Neurological Disorders and Stroke (NINDS) Udall Parkinson’s Disease Research Center of Excellence, 115 Mill Street, Belmont, Massachusetts 02478, USA.</nlm:aff></affiliation></author><author><name sortKey="Astradsson, Arnar" sort="Astradsson, Arnar" uniqKey="Astradsson A" first="Arnar" last="Astradsson">Arnar Astradsson</name><affiliation><nlm:aff id="A2">Harvard University and McLean Hospital, US National Institute of Neurological Disorders and Stroke (NINDS) Udall Parkinson’s Disease Research Center of Excellence, 115 Mill Street, Belmont, Massachusetts 02478, USA.</nlm:aff></affiliation></author><author><name sortKey="Mukhida, Karim" sort="Mukhida, Karim" uniqKey="Mukhida K" first="Karim" last="Mukhida">Karim Mukhida</name><affiliation><nlm:aff id="A1">Dalhousie University and Queen Elizabeth II Health Sciences Centre, Division of Neurosurgery and Departments of Anatomy & Neurobiology and Pharmacology, 1976 Summer Street, Halifax, Nova Scotia B3H 3A7, Canada.</nlm:aff></affiliation></author><author><name sortKey="Hallett, Penelope" sort="Hallett, Penelope" uniqKey="Hallett P" first="Penelope" last="Hallett">Penelope Hallett</name><affiliation><nlm:aff id="A2">Harvard University and McLean Hospital, US National Institute of Neurological Disorders and Stroke (NINDS) Udall Parkinson’s Disease Research Center of Excellence, 115 Mill Street, Belmont, Massachusetts 02478, USA.</nlm:aff></affiliation></author><author><name sortKey="Robertson, Harold" sort="Robertson, Harold" uniqKey="Robertson H" first="Harold" last="Robertson">Harold Robertson</name><affiliation><nlm:aff id="A1">Dalhousie University and Queen Elizabeth II Health Sciences Centre, Division of Neurosurgery and Departments of Anatomy & Neurobiology and Pharmacology, 1976 Summer Street, Halifax, Nova Scotia B3H 3A7, Canada.</nlm:aff></affiliation></author><author><name sortKey="Tierney, Travis" sort="Tierney, Travis" uniqKey="Tierney T" first="Travis" last="Tierney">Travis Tierney</name><affiliation><nlm:aff id="A2">Harvard University and McLean Hospital, US National Institute of Neurological Disorders and Stroke (NINDS) Udall Parkinson’s Disease Research Center of Excellence, 115 Mill Street, Belmont, Massachusetts 02478, USA.</nlm:aff></affiliation></author><author><name sortKey="Holness, Renn" sort="Holness, Renn" uniqKey="Holness R" first="Renn" last="Holness">Renn Holness</name><affiliation><nlm:aff id="A1">Dalhousie University and Queen Elizabeth II Health Sciences Centre, Division of Neurosurgery and Departments of Anatomy & Neurobiology and Pharmacology, 1976 Summer Street, Halifax, Nova Scotia B3H 3A7, Canada.</nlm:aff></affiliation></author><author><name sortKey="Dagher, Alain" sort="Dagher, Alain" uniqKey="Dagher A" first="Alain" last="Dagher">Alain Dagher</name><affiliation><nlm:aff id="A3">McGill University and Montreal Neurological Institute, McConnell Brain Imaging Centre, 3801 University Street, Montreal, Quebec H3A 2B4, Canada.</nlm:aff></affiliation></author><author><name sortKey="Trojanowski, John Q" sort="Trojanowski, John Q" uniqKey="Trojanowski J" first="John Q" last="Trojanowski">John Q. Trojanowski</name><affiliation><nlm:aff id="A4">Center for Neurodegenerative Disease Research, Department of Pathology and Laboratory Medicine, Institute on Aging of the University of Pennsylvania, NINDS Udall Parkinson’s Disease Research Center of Excellence, 3600 Spruce Street, Philadelphia, Pennsylvania 19104, USA.</nlm:aff></affiliation></author><author><name sortKey="Isacson, Ole" sort="Isacson, Ole" uniqKey="Isacson O" first="Ole" last="Isacson">Ole Isacson</name><affiliation><nlm:aff id="A2">Harvard University and McLean Hospital, US National Institute of Neurological Disorders and Stroke (NINDS) Udall Parkinson’s Disease Research Center of Excellence, 115 Mill Street, Belmont, Massachusetts 02478, USA.</nlm:aff></affiliation></author></titleStmt><publicationStmt><idno type="wicri:source">PMC</idno><idno type="pmid">18391961</idno><idno type="pmc">2656682</idno><idno type="url">http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2656682</idno><idno type="RBID">PMC:2656682</idno><idno type="doi">10.1038/nm1752</idno><date when="2008">2008</date><idno type="wicri:Area/Pmc/Corpus">000447</idno><idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Corpus" wicri:corpus="PMC">000447</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en" level="a" type="main">Dopamine neurons implanted into people with Parkinson’s disease survive without pathology for 14 years</title><author><name sortKey="Mendez, Ivar" sort="Mendez, Ivar" uniqKey="Mendez I" first="Ivar" last="Mendez">Ivar Mendez</name><affiliation><nlm:aff id="A1">Dalhousie University and Queen Elizabeth II Health Sciences Centre, Division of Neurosurgery and Departments of Anatomy & Neurobiology and Pharmacology, 1976 Summer Street, Halifax, Nova Scotia B3H 3A7, Canada.</nlm:aff></affiliation></author><author><name sortKey="Vi Uela, Angel" sort="Vi Uela, Angel" uniqKey="Vi Uela A" first="Angel" last="Vi Uela">Angel Vi Uela</name><affiliation><nlm:aff id="A2">Harvard University and McLean Hospital, US National Institute of Neurological Disorders and Stroke (NINDS) Udall Parkinson’s Disease Research Center of Excellence, 115 Mill Street, Belmont, Massachusetts 02478, USA.</nlm:aff></affiliation></author><author><name sortKey="Astradsson, Arnar" sort="Astradsson, Arnar" uniqKey="Astradsson A" first="Arnar" last="Astradsson">Arnar Astradsson</name><affiliation><nlm:aff id="A2">Harvard University and McLean Hospital, US National Institute of Neurological Disorders and Stroke (NINDS) Udall Parkinson’s Disease Research Center of Excellence, 115 Mill Street, Belmont, Massachusetts 02478, USA.</nlm:aff></affiliation></author><author><name sortKey="Mukhida, Karim" sort="Mukhida, Karim" uniqKey="Mukhida K" first="Karim" last="Mukhida">Karim Mukhida</name><affiliation><nlm:aff id="A1">Dalhousie University and Queen Elizabeth II Health Sciences Centre, Division of Neurosurgery and Departments of Anatomy & Neurobiology and Pharmacology, 1976 Summer Street, Halifax, Nova Scotia B3H 3A7, Canada.</nlm:aff></affiliation></author><author><name sortKey="Hallett, Penelope" sort="Hallett, Penelope" uniqKey="Hallett P" first="Penelope" last="Hallett">Penelope Hallett</name><affiliation><nlm:aff id="A2">Harvard University and McLean Hospital, US National Institute of Neurological Disorders and Stroke (NINDS) Udall Parkinson’s Disease Research Center of Excellence, 115 Mill Street, Belmont, Massachusetts 02478, USA.</nlm:aff></affiliation></author><author><name sortKey="Robertson, Harold" sort="Robertson, Harold" uniqKey="Robertson H" first="Harold" last="Robertson">Harold Robertson</name><affiliation><nlm:aff id="A1">Dalhousie University and Queen Elizabeth II Health Sciences Centre, Division of Neurosurgery and Departments of Anatomy & Neurobiology and Pharmacology, 1976 Summer Street, Halifax, Nova Scotia B3H 3A7, Canada.</nlm:aff></affiliation></author><author><name sortKey="Tierney, Travis" sort="Tierney, Travis" uniqKey="Tierney T" first="Travis" last="Tierney">Travis Tierney</name><affiliation><nlm:aff id="A2">Harvard University and McLean Hospital, US National Institute of Neurological Disorders and Stroke (NINDS) Udall Parkinson’s Disease Research Center of Excellence, 115 Mill Street, Belmont, Massachusetts 02478, USA.</nlm:aff></affiliation></author><author><name sortKey="Holness, Renn" sort="Holness, Renn" uniqKey="Holness R" first="Renn" last="Holness">Renn Holness</name><affiliation><nlm:aff id="A1">Dalhousie University and Queen Elizabeth II Health Sciences Centre, Division of Neurosurgery and Departments of Anatomy & Neurobiology and Pharmacology, 1976 Summer Street, Halifax, Nova Scotia B3H 3A7, Canada.</nlm:aff></affiliation></author><author><name sortKey="Dagher, Alain" sort="Dagher, Alain" uniqKey="Dagher A" first="Alain" last="Dagher">Alain Dagher</name><affiliation><nlm:aff id="A3">McGill University and Montreal Neurological Institute, McConnell Brain Imaging Centre, 3801 University Street, Montreal, Quebec H3A 2B4, Canada.</nlm:aff></affiliation></author><author><name sortKey="Trojanowski, John Q" sort="Trojanowski, John Q" uniqKey="Trojanowski J" first="John Q" last="Trojanowski">John Q. Trojanowski</name><affiliation><nlm:aff id="A4">Center for Neurodegenerative Disease Research, Department of Pathology and Laboratory Medicine, Institute on Aging of the University of Pennsylvania, NINDS Udall Parkinson’s Disease Research Center of Excellence, 3600 Spruce Street, Philadelphia, Pennsylvania 19104, USA.</nlm:aff></affiliation></author><author><name sortKey="Isacson, Ole" sort="Isacson, Ole" uniqKey="Isacson O" first="Ole" last="Isacson">Ole Isacson</name><affiliation><nlm:aff id="A2">Harvard University and McLean Hospital, US National Institute of Neurological Disorders and Stroke (NINDS) Udall Parkinson’s Disease Research Center of Excellence, 115 Mill Street, Belmont, Massachusetts 02478, USA.</nlm:aff></affiliation></author></analytic><series><title level="j">Nature medicine</title><idno type="ISSN">1078-8956</idno><idno type="eISSN">1546-170X</idno><imprint><date when="2008">2008</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en"><p id="P4">Postmortem analysis of five subjects with Parkinson’s disease9–14 years after transplantation of fetal midbrain cell suspensions revealed surviving grafts that included dopamine and serotonin neurons without pathology. These findings are important for the understanding of the etiopathogenesis of midbrain dopamine neuron degeneration and future use of cell replacement therapies.</p></div></front></TEI><pmc article-type="research-article" xml:lang="EN"><pmc-comment>The publisher of this article does not allow downloading of the full text in XML form.</pmc-comment>
<pmc-dir>properties manuscript</pmc-dir>
<front><journal-meta><journal-id journal-id-type="nlm-journal-id">9502015</journal-id><journal-id journal-id-type="pubmed-jr-id">8791</journal-id><journal-id journal-id-type="nlm-ta">Nat Med</journal-id><journal-title>Nature medicine</journal-title><issn pub-type="ppub">1078-8956</issn><issn pub-type="epub">1546-170X</issn></journal-meta><article-meta><article-id pub-id-type="pmid">18391961</article-id><article-id pub-id-type="pmc">2656682</article-id><article-id pub-id-type="manuscript">NIHMS82029</article-id><article-id pub-id-type="doi">10.1038/nm1752</article-id><article-categories><subj-group subj-group-type="heading"><subject>Article</subject></subj-group></article-categories><title-group><article-title>Dopamine neurons implanted into people with Parkinson’s disease survive without pathology for 14 years</article-title></title-group><contrib-group><contrib contrib-type="author"><name><surname>Mendez</surname><given-names>Ivar</given-names></name><xref ref-type="aff" rid="A1">1</xref><xref ref-type="author-notes" rid="FN1">5</xref></contrib><contrib contrib-type="author"><name><surname>Viñuela</surname><given-names>Angel</given-names></name><xref ref-type="aff" rid="A2">2</xref><xref ref-type="author-notes" rid="FN1">5</xref></contrib><contrib contrib-type="author"><name><surname>Astradsson</surname><given-names>Arnar</given-names></name><xref ref-type="aff" rid="A2">2</xref></contrib><contrib contrib-type="author"><name><surname>Mukhida</surname><given-names>Karim</given-names></name><xref ref-type="aff" rid="A1">1</xref></contrib><contrib contrib-type="author"><name><surname>Hallett</surname><given-names>Penelope</given-names></name><xref ref-type="aff" rid="A2">2</xref></contrib><contrib contrib-type="author"><name><surname>Robertson</surname><given-names>Harold</given-names></name><xref ref-type="aff" rid="A1">1</xref></contrib><contrib contrib-type="author"><name><surname>Tierney</surname><given-names>Travis</given-names></name><xref ref-type="aff" rid="A2">2</xref></contrib><contrib contrib-type="author"><name><surname>Holness</surname><given-names>Renn</given-names></name><xref ref-type="aff" rid="A1">1</xref></contrib><contrib contrib-type="author"><name><surname>Dagher</surname><given-names>Alain</given-names></name><xref ref-type="aff" rid="A3">3</xref></contrib><contrib contrib-type="author"><name><surname>Trojanowski</surname><given-names>John Q</given-names></name><xref ref-type="aff" rid="A4">4</xref></contrib><contrib contrib-type="author"><name><surname>Isacson</surname><given-names>Ole</given-names></name><xref ref-type="aff" rid="A2">2</xref></contrib></contrib-group><aff id="A1"><label>1</label>Dalhousie University and Queen Elizabeth II Health Sciences Centre, Division of Neurosurgery and Departments of Anatomy & Neurobiology and Pharmacology, 1976 Summer Street, Halifax, Nova Scotia B3H 3A7, Canada.</aff><aff id="A2"><label>2</label>Harvard University and McLean Hospital, US National Institute of Neurological Disorders and Stroke (NINDS) Udall Parkinson’s Disease Research Center of Excellence, 115 Mill Street, Belmont, Massachusetts 02478, USA.</aff><aff id="A3"><label>3</label>McGill University and Montreal Neurological Institute, McConnell Brain Imaging Centre, 3801 University Street, Montreal, Quebec H3A 2B4, Canada.</aff><aff id="A4"><label>4</label>Center for Neurodegenerative Disease Research, Department of Pathology and Laboratory Medicine, Institute on Aging of the University of Pennsylvania, NINDS Udall Parkinson’s Disease Research Center of Excellence, 3600 Spruce Street, Philadelphia, Pennsylvania 19104, USA.</aff><author-notes><fn id="FN1" fn-type="equal"><label>5</label><p id="P1">These authors contributed equally to this work.</p></fn><fn id="FN2"><p id="P2"><bold>AUTHOR CONTRIBUTIONS</bold></p><p id="P3">I.M. and A.V. designed research, performed research, analyzed data and wrote the paper. A.A. and P.H. performed research, analyzed data and wrote the paper. K.M. analyzed data and wrote the paper. H.R., T.T., R.H. and A.D. performed research and analyzed data. J.Q.T. performed neuropathology staining, analyzed raw data, evaluated and interpreted data and wrote the paper. O.I. designed research, performed research, analyzed raw data, evaluated and interpreted data and wrote the paper.</p></fn><corresp id="cor1">Correspondence should be addressed to O.I. (<email>isacson@hms.harvard.edu</email>)</corresp></author-notes><pub-date pub-type="nihms-submitted"><day>29</day><month>12</month><year>2008</year></pub-date><pub-date pub-type="epub"><day>6</day><month>4</month><year>2008</year></pub-date><pub-date pub-type="ppub"><month>5</month><year>2008</year></pub-date><pub-date pub-type="pmc-release"><day>17</day><month>3</month><year>2009</year></pub-date><volume>14</volume><issue>5</issue><fpage>507</fpage><lpage>509</lpage><related-article journal-id-type="nlm-ta" journal-id="Nat Med" related-article-type="commentary" page="483" id="N0x1ca3540N0x2874ee8" xlink:href="18463652" ext-link-type="pubmed" vol="14"></related-article><abstract><p id="P4">Postmortem analysis of five subjects with Parkinson’s disease9–14 years after transplantation of fetal midbrain cell suspensions revealed surviving grafts that included dopamine and serotonin neurons without pathology. These findings are important for the understanding of the etiopathogenesis of midbrain dopamine neuron degeneration and future use of cell replacement therapies.</p></abstract><contract-num rid="NS1">P50 NS039793-08</contract-num><contract-sponsor id="NS1">National Institute of Neurological Disorders and Stroke : NINDS</contract-sponsor></article-meta></front></pmc></record>Pour manipuler ce document sous Unix (Dilib)
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