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<record><TEI><teiHeader><fileDesc><titleStmt><title xml:lang="en">Replication of association between <italic>ELAVL4</italic> and Parkinson disease: the <italic>Gene</italic>PD study</title><author><name sortKey="Destefano, Anita L" sort="Destefano, Anita L" uniqKey="Destefano A" first="Anita L." last="Destefano">Anita L. Destefano</name></author><author><name sortKey="Latourelle, Jeanne" sort="Latourelle, Jeanne" uniqKey="Latourelle J" first="Jeanne" last="Latourelle">Jeanne Latourelle</name></author><author><name sortKey="Lew, Mark F" sort="Lew, Mark F" uniqKey="Lew M" first="Mark F." last="Lew">Mark F. Lew</name></author><author><name sortKey="Suchowersky, Oksana" sort="Suchowersky, Oksana" uniqKey="Suchowersky O" first="Oksana" last="Suchowersky">Oksana Suchowersky</name></author><author><name sortKey="Klein, Christine" sort="Klein, Christine" uniqKey="Klein C" first="Christine" last="Klein">Christine Klein</name></author><author><name sortKey="Golbe, Lawrence I" sort="Golbe, Lawrence I" uniqKey="Golbe L" first="Lawrence I." last="Golbe">Lawrence I. Golbe</name></author><author><name sortKey="Mark, Margery H" sort="Mark, Margery H" uniqKey="Mark M" first="Margery H." last="Mark">Margery H. Mark</name></author><author><name sortKey="Growdon, John H" sort="Growdon, John H" uniqKey="Growdon J" first="John H." last="Growdon">John H. Growdon</name></author><author><name sortKey="Wooten, G Fredrick" sort="Wooten, G Fredrick" uniqKey="Wooten G" first="G. Fredrick" last="Wooten">G. Fredrick Wooten</name></author><author><name sortKey="Watts, Ray" sort="Watts, Ray" uniqKey="Watts R" first="Ray" last="Watts">Ray Watts</name></author><author><name sortKey="Guttman, Mark" sort="Guttman, Mark" uniqKey="Guttman M" first="Mark" last="Guttman">Mark Guttman</name></author><author><name sortKey="Racette, Brad A" sort="Racette, Brad A" uniqKey="Racette B" first="Brad A." last="Racette">Brad A. Racette</name></author><author><name sortKey="Perlmutter, Joel S" sort="Perlmutter, Joel S" uniqKey="Perlmutter J" first="Joel S." last="Perlmutter">Joel S. Perlmutter</name></author><author><name sortKey="Marlor, Lynn" sort="Marlor, Lynn" uniqKey="Marlor L" first="Lynn" last="Marlor">Lynn Marlor</name></author><author><name sortKey="Shill, Holly A" sort="Shill, Holly A" uniqKey="Shill H" first="Holly A." last="Shill">Holly A. Shill</name></author><author><name sortKey="Singer, Carlos" sort="Singer, Carlos" uniqKey="Singer C" first="Carlos" last="Singer">Carlos Singer</name></author><author><name sortKey="Goldwurm, Stefano" sort="Goldwurm, Stefano" uniqKey="Goldwurm S" first="Stefano" last="Goldwurm">Stefano Goldwurm</name></author><author><name sortKey="Pezzoli, Gianni" sort="Pezzoli, Gianni" uniqKey="Pezzoli G" first="Gianni" last="Pezzoli">Gianni Pezzoli</name></author><author><name sortKey="Saint Hilaire, Marie H" sort="Saint Hilaire, Marie H" uniqKey="Saint Hilaire M" first="Marie H." last="Saint-Hilaire">Marie H. Saint-Hilaire</name></author><author><name sortKey="Hendricks, Audrey E" sort="Hendricks, Audrey E" uniqKey="Hendricks A" first="Audrey E." last="Hendricks">Audrey E. Hendricks</name></author><author><name sortKey="Gower, Adam" sort="Gower, Adam" uniqKey="Gower A" first="Adam" last="Gower">Adam Gower</name></author><author><name sortKey="Williamson, Sally" sort="Williamson, Sally" uniqKey="Williamson S" first="Sally" last="Williamson">Sally Williamson</name></author><author><name sortKey="Nagle, Michael W" sort="Nagle, Michael W" uniqKey="Nagle M" first="Michael W." last="Nagle">Michael W. Nagle</name></author><author><name sortKey="Wilk, Jemma B" sort="Wilk, Jemma B" uniqKey="Wilk J" first="Jemma B." last="Wilk">Jemma B. Wilk</name></author><author><name sortKey="Massood, Tiffany" sort="Massood, Tiffany" uniqKey="Massood T" first="Tiffany" last="Massood">Tiffany Massood</name></author><author><name sortKey="Huskey, Karen W" sort="Huskey, Karen W" uniqKey="Huskey K" first="Karen W." last="Huskey">Karen W. Huskey</name></author><author><name sortKey="Baker, Kenneth B" sort="Baker, Kenneth B" uniqKey="Baker K" first="Kenneth B." last="Baker">Kenneth B. Baker</name></author><author><name sortKey="Itin, Ilia" sort="Itin, Ilia" uniqKey="Itin I" first="Ilia" last="Itin">Ilia Itin</name></author><author><name sortKey="Litvan, Irene" sort="Litvan, Irene" uniqKey="Litvan I" first="Irene" last="Litvan">Irene Litvan</name></author><author><name sortKey="Nicholson, Garth" sort="Nicholson, Garth" uniqKey="Nicholson G" first="Garth" last="Nicholson">Garth Nicholson</name></author><author><name sortKey="Corbett, Alastair" sort="Corbett, Alastair" uniqKey="Corbett A" first="Alastair" last="Corbett">Alastair Corbett</name></author><author><name sortKey="Nance, Martha" sort="Nance, Martha" uniqKey="Nance M" first="Martha" last="Nance">Martha Nance</name></author><author><name sortKey="Drasby, Edward" sort="Drasby, Edward" uniqKey="Drasby E" first="Edward" last="Drasby">Edward Drasby</name></author><author><name sortKey="Isaacson, Stuart" sort="Isaacson, Stuart" uniqKey="Isaacson S" first="Stuart" last="Isaacson">Stuart Isaacson</name></author><author><name sortKey="Burn, David J" sort="Burn, David J" uniqKey="Burn D" first="David J." last="Burn">David J. Burn</name></author><author><name sortKey="Chinnery, Patrick F" sort="Chinnery, Patrick F" uniqKey="Chinnery P" first="Patrick F." last="Chinnery">Patrick F. Chinnery</name></author><author><name sortKey="Pramstaller, Peter P" sort="Pramstaller, Peter P" uniqKey="Pramstaller P" first="Peter P." last="Pramstaller">Peter P. Pramstaller</name></author><author><name sortKey="Al Hinti, Jomana" sort="Al Hinti, Jomana" uniqKey="Al Hinti J" first="Jomana" last="Al-Hinti">Jomana Al-Hinti</name></author><author><name sortKey="Moller, Anette T" sort="Moller, Anette T" uniqKey="Moller A" first="Anette T." last="Moller">Anette T. Moller</name></author><author><name sortKey="Ostergaard, Karen" sort="Ostergaard, Karen" uniqKey="Ostergaard K" first="Karen" last="Ostergaard">Karen Ostergaard</name></author><author><name sortKey="Sherman, Scott J" sort="Sherman, Scott J" uniqKey="Sherman S" first="Scott J." last="Sherman">Scott J. Sherman</name></author><author><name sortKey="Roxburgh, Richard" sort="Roxburgh, Richard" uniqKey="Roxburgh R" first="Richard" last="Roxburgh">Richard Roxburgh</name></author><author><name sortKey="Snow, Barry" sort="Snow, Barry" uniqKey="Snow B" first="Barry" last="Snow">Barry Snow</name></author><author><name sortKey="Slevin, John T" sort="Slevin, John T" uniqKey="Slevin J" first="John T." last="Slevin">John T. Slevin</name></author><author><name sortKey="Cambi, Franca" sort="Cambi, Franca" uniqKey="Cambi F" first="Franca" last="Cambi">Franca Cambi</name></author><author><name sortKey="Gusella, James F" sort="Gusella, James F" uniqKey="Gusella J" first="James F." last="Gusella">James F. Gusella</name></author><author><name sortKey="Myers, Richard H" sort="Myers, Richard H" uniqKey="Myers R" first="Richard H." last="Myers">Richard H. Myers</name></author></titleStmt><publicationStmt><idno type="wicri:source">PMC</idno><idno type="pmid">18587682</idno><idno type="pmc">2716559</idno><idno type="url">http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2716559</idno><idno type="RBID">PMC:2716559</idno><idno type="doi">10.1007/s00439-008-0526-4</idno><date when="2008">2008</date><idno type="wicri:Area/Pmc/Corpus">000412</idno><idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Corpus" wicri:corpus="PMC">000412</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en" level="a" type="main">Replication of association between <italic>ELAVL4</italic> and Parkinson disease: the <italic>Gene</italic>PD study</title><author><name sortKey="Destefano, Anita L" sort="Destefano, Anita L" uniqKey="Destefano A" first="Anita L." last="Destefano">Anita L. Destefano</name></author><author><name sortKey="Latourelle, Jeanne" sort="Latourelle, Jeanne" uniqKey="Latourelle J" first="Jeanne" last="Latourelle">Jeanne Latourelle</name></author><author><name sortKey="Lew, Mark F" sort="Lew, Mark F" uniqKey="Lew M" first="Mark F." last="Lew">Mark F. Lew</name></author><author><name sortKey="Suchowersky, Oksana" sort="Suchowersky, Oksana" uniqKey="Suchowersky O" first="Oksana" last="Suchowersky">Oksana Suchowersky</name></author><author><name sortKey="Klein, Christine" sort="Klein, Christine" uniqKey="Klein C" first="Christine" last="Klein">Christine Klein</name></author><author><name sortKey="Golbe, Lawrence I" sort="Golbe, Lawrence I" uniqKey="Golbe L" first="Lawrence I." last="Golbe">Lawrence I. Golbe</name></author><author><name sortKey="Mark, Margery H" sort="Mark, Margery H" uniqKey="Mark M" first="Margery H." last="Mark">Margery H. Mark</name></author><author><name sortKey="Growdon, John H" sort="Growdon, John H" uniqKey="Growdon J" first="John H." last="Growdon">John H. Growdon</name></author><author><name sortKey="Wooten, G Fredrick" sort="Wooten, G Fredrick" uniqKey="Wooten G" first="G. Fredrick" last="Wooten">G. Fredrick Wooten</name></author><author><name sortKey="Watts, Ray" sort="Watts, Ray" uniqKey="Watts R" first="Ray" last="Watts">Ray Watts</name></author><author><name sortKey="Guttman, Mark" sort="Guttman, Mark" uniqKey="Guttman M" first="Mark" last="Guttman">Mark Guttman</name></author><author><name sortKey="Racette, Brad A" sort="Racette, Brad A" uniqKey="Racette B" first="Brad A." last="Racette">Brad A. Racette</name></author><author><name sortKey="Perlmutter, Joel S" sort="Perlmutter, Joel S" uniqKey="Perlmutter J" first="Joel S." last="Perlmutter">Joel S. Perlmutter</name></author><author><name sortKey="Marlor, Lynn" sort="Marlor, Lynn" uniqKey="Marlor L" first="Lynn" last="Marlor">Lynn Marlor</name></author><author><name sortKey="Shill, Holly A" sort="Shill, Holly A" uniqKey="Shill H" first="Holly A." last="Shill">Holly A. Shill</name></author><author><name sortKey="Singer, Carlos" sort="Singer, Carlos" uniqKey="Singer C" first="Carlos" last="Singer">Carlos Singer</name></author><author><name sortKey="Goldwurm, Stefano" sort="Goldwurm, Stefano" uniqKey="Goldwurm S" first="Stefano" last="Goldwurm">Stefano Goldwurm</name></author><author><name sortKey="Pezzoli, Gianni" sort="Pezzoli, Gianni" uniqKey="Pezzoli G" first="Gianni" last="Pezzoli">Gianni Pezzoli</name></author><author><name sortKey="Saint Hilaire, Marie H" sort="Saint Hilaire, Marie H" uniqKey="Saint Hilaire M" first="Marie H." last="Saint-Hilaire">Marie H. Saint-Hilaire</name></author><author><name sortKey="Hendricks, Audrey E" sort="Hendricks, Audrey E" uniqKey="Hendricks A" first="Audrey E." last="Hendricks">Audrey E. Hendricks</name></author><author><name sortKey="Gower, Adam" sort="Gower, Adam" uniqKey="Gower A" first="Adam" last="Gower">Adam Gower</name></author><author><name sortKey="Williamson, Sally" sort="Williamson, Sally" uniqKey="Williamson S" first="Sally" last="Williamson">Sally Williamson</name></author><author><name sortKey="Nagle, Michael W" sort="Nagle, Michael W" uniqKey="Nagle M" first="Michael W." last="Nagle">Michael W. Nagle</name></author><author><name sortKey="Wilk, Jemma B" sort="Wilk, Jemma B" uniqKey="Wilk J" first="Jemma B." last="Wilk">Jemma B. Wilk</name></author><author><name sortKey="Massood, Tiffany" sort="Massood, Tiffany" uniqKey="Massood T" first="Tiffany" last="Massood">Tiffany Massood</name></author><author><name sortKey="Huskey, Karen W" sort="Huskey, Karen W" uniqKey="Huskey K" first="Karen W." last="Huskey">Karen W. Huskey</name></author><author><name sortKey="Baker, Kenneth B" sort="Baker, Kenneth B" uniqKey="Baker K" first="Kenneth B." last="Baker">Kenneth B. Baker</name></author><author><name sortKey="Itin, Ilia" sort="Itin, Ilia" uniqKey="Itin I" first="Ilia" last="Itin">Ilia Itin</name></author><author><name sortKey="Litvan, Irene" sort="Litvan, Irene" uniqKey="Litvan I" first="Irene" last="Litvan">Irene Litvan</name></author><author><name sortKey="Nicholson, Garth" sort="Nicholson, Garth" uniqKey="Nicholson G" first="Garth" last="Nicholson">Garth Nicholson</name></author><author><name sortKey="Corbett, Alastair" sort="Corbett, Alastair" uniqKey="Corbett A" first="Alastair" last="Corbett">Alastair Corbett</name></author><author><name sortKey="Nance, Martha" sort="Nance, Martha" uniqKey="Nance M" first="Martha" last="Nance">Martha Nance</name></author><author><name sortKey="Drasby, Edward" sort="Drasby, Edward" uniqKey="Drasby E" first="Edward" last="Drasby">Edward Drasby</name></author><author><name sortKey="Isaacson, Stuart" sort="Isaacson, Stuart" uniqKey="Isaacson S" first="Stuart" last="Isaacson">Stuart Isaacson</name></author><author><name sortKey="Burn, David J" sort="Burn, David J" uniqKey="Burn D" first="David J." last="Burn">David J. Burn</name></author><author><name sortKey="Chinnery, Patrick F" sort="Chinnery, Patrick F" uniqKey="Chinnery P" first="Patrick F." last="Chinnery">Patrick F. Chinnery</name></author><author><name sortKey="Pramstaller, Peter P" sort="Pramstaller, Peter P" uniqKey="Pramstaller P" first="Peter P." last="Pramstaller">Peter P. Pramstaller</name></author><author><name sortKey="Al Hinti, Jomana" sort="Al Hinti, Jomana" uniqKey="Al Hinti J" first="Jomana" last="Al-Hinti">Jomana Al-Hinti</name></author><author><name sortKey="Moller, Anette T" sort="Moller, Anette T" uniqKey="Moller A" first="Anette T." last="Moller">Anette T. Moller</name></author><author><name sortKey="Ostergaard, Karen" sort="Ostergaard, Karen" uniqKey="Ostergaard K" first="Karen" last="Ostergaard">Karen Ostergaard</name></author><author><name sortKey="Sherman, Scott J" sort="Sherman, Scott J" uniqKey="Sherman S" first="Scott J." last="Sherman">Scott J. Sherman</name></author><author><name sortKey="Roxburgh, Richard" sort="Roxburgh, Richard" uniqKey="Roxburgh R" first="Richard" last="Roxburgh">Richard Roxburgh</name></author><author><name sortKey="Snow, Barry" sort="Snow, Barry" uniqKey="Snow B" first="Barry" last="Snow">Barry Snow</name></author><author><name sortKey="Slevin, John T" sort="Slevin, John T" uniqKey="Slevin J" first="John T." last="Slevin">John T. Slevin</name></author><author><name sortKey="Cambi, Franca" sort="Cambi, Franca" uniqKey="Cambi F" first="Franca" last="Cambi">Franca Cambi</name></author><author><name sortKey="Gusella, James F" sort="Gusella, James F" uniqKey="Gusella J" first="James F." last="Gusella">James F. Gusella</name></author><author><name sortKey="Myers, Richard H" sort="Myers, Richard H" uniqKey="Myers R" first="Richard H." last="Myers">Richard H. Myers</name></author></analytic><series><title level="j">Human genetics</title><idno type="ISSN">0340-6717</idno><idno type="eISSN">1432-1203</idno><imprint><date when="2008">2008</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en"><p id="P1">Genetic variants in embryonic lethal, abnormal vision, Drosophila-like 4 (<italic>ELAVL4</italic>) have been reported to be associated with onset age of Parkinson disease (PD) or risk for PD affection in Caucasian populations. In the current study we genotyped three single nucleotide polymorphisms in <italic>ELAVL4</italic> in a Caucasian study sample consisting of 712 PD patients and 312 unrelated controls from the <italic>Gene</italic>PD study. The minor allele of rs967582 was associated with increased risk of PD (odds ratio = 1.46, nominal <italic>P</italic> value = 0.011) in the <italic>Gene</italic>PD population. The minor allele of rs967582 was also the risk allele for PD affection or earlier onset age in the previously studied populations. This replication of association with rs967582 in a third cohort further implicates <italic>ELAVL4</italic> as a PD susceptibility gene.</p></div></front></TEI><pmc article-type="research-article" xml:lang="EN"><pmc-comment>The publisher of this article does not allow downloading of the full text in XML form.</pmc-comment>
<pmc-dir>properties manuscript</pmc-dir>
<front><journal-meta><journal-id journal-id-type="nlm-journal-id">7613873</journal-id><journal-id journal-id-type="pubmed-jr-id">4137</journal-id><journal-id journal-id-type="nlm-ta">Hum Genet</journal-id><journal-title>Human genetics</journal-title><issn pub-type="ppub">0340-6717</issn><issn pub-type="epub">1432-1203</issn></journal-meta><article-meta><article-id pub-id-type="pmid">18587682</article-id><article-id pub-id-type="pmc">2716559</article-id><article-id pub-id-type="manuscript">NIHMS99146</article-id><article-id pub-id-type="doi">10.1007/s00439-008-0526-4</article-id><article-categories><subj-group subj-group-type="heading"><subject>Article</subject></subj-group></article-categories><title-group><article-title>Replication of association between <italic>ELAVL4</italic> and Parkinson disease: the <italic>Gene</italic>PD study</article-title></title-group><contrib-group><contrib contrib-type="author"><name><surname>DeStefano</surname><given-names>Anita L.</given-names></name><email>adestef@bu.edu</email><aff id="A1">Department of Biostatistics, Boston University School of Public Health, 715 Albany Street, Crosstown Center, 3rd floor, Boston, MA 02118, USA</aff><aff id="A2">Department of Neurology, Boston University School of Medicine, Boston, MA 02118, USA</aff></contrib><contrib contrib-type="author"><name><surname>Latourelle</surname><given-names>Jeanne</given-names></name><aff id="A3">Department of Neurology, Boston University School of Medicine, Boston, MA 02118, USA</aff></contrib><contrib contrib-type="author"><name><surname>Lew</surname><given-names>Mark F.</given-names></name><aff id="A4">Department of Neurology, University Southern California School of Medicine, Los Angeles, CA 90033, USA</aff></contrib><contrib contrib-type="author"><name><surname>Suchowersky</surname><given-names>Oksana</given-names></name><aff id="A5">Department of Clinical Neuroscience, University of Calgary, Calgary, AB, Canada T2N-4N1</aff></contrib><contrib contrib-type="author"><name><surname>Klein</surname><given-names>Christine</given-names></name><aff id="A6">Department of Neurology, University of Lübeck, 23538 Lübeck, Germany</aff></contrib><contrib contrib-type="author"><name><surname>Golbe</surname><given-names>Lawrence I.</given-names></name><aff id="A7">Department of Neurology, University of Medicine and Dentistry of New Jersey-Robert Wood Johnson Medical School, New Brunswick, NJ 08903, USA</aff></contrib><contrib contrib-type="author"><name><surname>Mark</surname><given-names>Margery H.</given-names></name><aff id="A8">Department of Neurology, University of Medicine and Dentistry of New Jersey-Robert Wood Johnson Medical School, New Brunswick, NJ 08903, USA</aff></contrib><contrib contrib-type="author"><name><surname>Growdon</surname><given-names>John H.</given-names></name><aff id="A9">Department of Neurology, Massachusetts General Hospital, Boston, MA 02114, USA</aff></contrib><contrib contrib-type="author"><name><surname>Wooten</surname><given-names>G. Fredrick</given-names></name><aff id="A10">Department of Neurology, University of Virginia Health System, Charlottesville, VA 22908, USA</aff></contrib><contrib contrib-type="author"><name><surname>Watts</surname><given-names>Ray</given-names></name><aff id="A11">Department of Neurology, University of Alabama at Birmingham, Birmingham, AL 35233, USA</aff></contrib><contrib contrib-type="author"><name><surname>Guttman</surname><given-names>Mark</given-names></name><aff id="A12">Department of Medicine, University of Toronto, Toronto, Canada L6B-1C9</aff></contrib><contrib contrib-type="author"><name><surname>Racette</surname><given-names>Brad A.</given-names></name><aff id="A13">Department of Neurology, Washington University School of Medicine, Saint Louis, MO 63110, USA</aff></contrib><contrib contrib-type="author"><name><surname>Perlmutter</surname><given-names>Joel S.</given-names></name><aff id="A14">Department of Neurology, Washington University School of Medicine, Saint Louis, MO 63110, USA</aff></contrib><contrib contrib-type="author"><name><surname>Marlor</surname><given-names>Lynn</given-names></name><aff id="A15">Barrow Neurological Institute, Phoenix, AZ 85013, USA</aff></contrib><contrib contrib-type="author"><name><surname>Shill</surname><given-names>Holly A.</given-names></name><aff id="A16">Sun Health Research Institute, Sun City, AZ 85351, USA</aff></contrib><contrib contrib-type="author"><name><surname>Singer</surname><given-names>Carlos</given-names></name><aff id="A17">Department of Neurology, University of Miami, Miami, FL 33136, USA</aff></contrib><contrib contrib-type="author"><name><surname>Goldwurm</surname><given-names>Stefano</given-names></name><aff id="A18">Parkinson Institute, Istituti Clinici di Perfezionamento, 39100 Milan, Italy</aff></contrib><contrib contrib-type="author"><name><surname>Pezzoli</surname><given-names>Gianni</given-names></name><aff id="A19">Parkinson Institute, Istituti Clinici di Perfezionamento, 39100 Milan, Italy</aff></contrib><contrib contrib-type="author"><name><surname>Saint-Hilaire</surname><given-names>Marie H.</given-names></name><aff id="A20">Department of Neurology, Boston University School of Medicine, Boston, MA 02118, USA</aff></contrib><contrib contrib-type="author"><name><surname>Hendricks</surname><given-names>Audrey E.</given-names></name><aff id="A21">Department of Biostatistics, Boston University School of Public Health, 715 Albany Street, Crosstown Center, 3rd floor, Boston, MA 02118, USA</aff></contrib><contrib contrib-type="author"><name><surname>Gower</surname><given-names>Adam</given-names></name><aff id="A22">Department of Bioinformatics, Boston University, Boston, MA 02215, USA</aff></contrib><contrib contrib-type="author"><name><surname>Williamson</surname><given-names>Sally</given-names></name><aff id="A23">Department of Neurology, Boston University School of Medicine, Boston, MA 02118, USA</aff></contrib><contrib contrib-type="author"><name><surname>Nagle</surname><given-names>Michael W.</given-names></name><aff id="A24">Department of Neurology, Boston University School of Medicine, Boston, MA 02118, USA</aff></contrib><contrib contrib-type="author"><name><surname>Wilk</surname><given-names>Jemma B.</given-names></name><aff id="A25">Department of Neurology, Boston University School of Medicine, Boston, MA 02118, USA</aff></contrib><contrib contrib-type="author"><name><surname>Massood</surname><given-names>Tiffany</given-names></name><aff id="A26">Department of Neurology, Boston University School of Medicine, Boston, MA 02118, USA</aff></contrib><contrib contrib-type="author"><name><surname>Huskey</surname><given-names>Karen W.</given-names></name><aff id="A27">Department of Biostatistics, Boston University School of Public Health, 715 Albany Street, Crosstown Center, 3rd floor, Boston, MA 02118, USA</aff><aff id="A28">Department of Neurology, Boston University School of Medicine, Boston, MA 02118, USA</aff></contrib><contrib contrib-type="author"><name><surname>Baker</surname><given-names>Kenneth B.</given-names></name><aff id="A29">Departments of Neurology and Neuroscience, Cleveland Clinic Foundation, Cleveland, OH 44195, USA</aff></contrib><contrib contrib-type="author"><name><surname>Itin</surname><given-names>Ilia</given-names></name><aff id="A30">Departments of Neurology and Neuroscience, Cleveland Clinic Foundation, Cleveland, OH 44195, USA</aff></contrib><contrib contrib-type="author"><name><surname>Litvan</surname><given-names>Irene</given-names></name><aff id="A31">Department of Neurology, University of Louisville School of Medicine, Louisville, KY 40202, USA</aff></contrib><contrib contrib-type="author"><name><surname>Nicholson</surname><given-names>Garth</given-names></name><aff id="A32">Neurology Department, University of Sydney ANZAC Research Institute, Concord Hospital, Sydney, Australia</aff></contrib><contrib contrib-type="author"><name><surname>Corbett</surname><given-names>Alastair</given-names></name><aff id="A33">Neurology Department, University of Sydney ANZAC Research Institute, Concord Hospital, Sydney, Australia</aff></contrib><contrib contrib-type="author"><name><surname>Nance</surname><given-names>Martha</given-names></name><aff id="A34">Struthers Parkinson’s Center, Minneapolis, MN 55427, USA</aff></contrib><contrib contrib-type="author"><name><surname>Drasby</surname><given-names>Edward</given-names></name><aff id="A35">Port City Neurology, Scarborough, ME 04074, USA</aff></contrib><contrib contrib-type="author"><name><surname>Isaacson</surname><given-names>Stuart</given-names></name><aff id="A36">Parkinson’s Disease and Movement Disorder Center of Boca Raton, Boca Raton, FL 33486, USA</aff></contrib><contrib contrib-type="author"><name><surname>Burn</surname><given-names>David J.</given-names></name><aff id="A37">Institute for Ageing and Health/Regional Neurosciences Centre, Newcastle University, NE4 6BE Newcastle upon Tyne, UK</aff></contrib><contrib contrib-type="author"><name><surname>Chinnery</surname><given-names>Patrick F.</given-names></name><aff id="A38">Institute for Ageing and Health/Regional Neurosciences Centre, Newcastle University, NE4 6BE Newcastle upon Tyne, UK</aff></contrib><contrib contrib-type="author"><name><surname>Pramstaller</surname><given-names>Peter P.</given-names></name><aff id="A39">Department of Neurology, General Regional Hospital Bolzano, 39100 Bolzano, Italy</aff></contrib><contrib contrib-type="author"><name><surname>Al-hinti</surname><given-names>Jomana</given-names></name><aff id="A40">Department of Neurology, University of Arkansas for Medical Sciences, Little Rock, AR 72205, USA</aff></contrib><contrib contrib-type="author"><name><surname>Moller</surname><given-names>Anette T.</given-names></name><aff id="A41">Department of Neurology, Aarhus University Hospital, 8000 Aarhus, Denmark</aff></contrib><contrib contrib-type="author"><name><surname>Ostergaard</surname><given-names>Karen</given-names></name><aff id="A42">Department of Neurology, Aarhus University Hospital, 8000 Aarhus, Denmark</aff></contrib><contrib contrib-type="author"><name><surname>Sherman</surname><given-names>Scott J.</given-names></name><aff id="A43">Department of Neurology, University of Arizona, Tucson, AZ 85724, USA</aff></contrib><contrib contrib-type="author"><name><surname>Roxburgh</surname><given-names>Richard</given-names></name><aff id="A44">Department of Neurology, Auckland City Hospital, Auckland, New Zealand</aff></contrib><contrib contrib-type="author"><name><surname>Snow</surname><given-names>Barry</given-names></name><aff id="A45">Department of Neurology, Auckland City Hospital, Auckland, New Zealand</aff></contrib><contrib contrib-type="author"><name><surname>Slevin</surname><given-names>John T.</given-names></name><aff id="A46">Department of Neurology, University of Kentucky College of Medicine, Lexington, KY 40536, USA</aff></contrib><contrib contrib-type="author"><name><surname>Cambi</surname><given-names>Franca</given-names></name><aff id="A47">Department of Neurology, University of Kentucky College of Medicine, Lexington, KY 40536, USA</aff></contrib><contrib contrib-type="author"><name><surname>Gusella</surname><given-names>James F.</given-names></name><aff id="A48">Molecular Neurogenetics Unit, Center for Human Genetic Research, Massachusetts General Hospital, Harvard Medical School Boston, MA 02114 Boston, USA</aff></contrib><contrib contrib-type="author"><name><surname>Myers</surname><given-names>Richard H.</given-names></name><aff id="A49">Department of Neurology, Boston University School of Medicine, Boston, MA 02118, USA</aff></contrib></contrib-group><pub-date pub-type="nihms-submitted"><day>4</day><month>3</month><year>2009</year></pub-date><pub-date pub-type="epub"><day>29</day><month>6</month><year>2008</year></pub-date><pub-date pub-type="ppub"><month>8</month><year>2008</year></pub-date><pub-date pub-type="pmc-release"><day>1</day><month>8</month><year>2009</year></pub-date><volume>124</volume><issue>1</issue><fpage>95</fpage><lpage>99</lpage><permissions><copyright-statement>© Springer-Verlag 2008</copyright-statement><copyright-year>2008</copyright-year></permissions><abstract><p id="P1">Genetic variants in embryonic lethal, abnormal vision, Drosophila-like 4 (<italic>ELAVL4</italic>) have been reported to be associated with onset age of Parkinson disease (PD) or risk for PD affection in Caucasian populations. In the current study we genotyped three single nucleotide polymorphisms in <italic>ELAVL4</italic> in a Caucasian study sample consisting of 712 PD patients and 312 unrelated controls from the <italic>Gene</italic>PD study. The minor allele of rs967582 was associated with increased risk of PD (odds ratio = 1.46, nominal <italic>P</italic> value = 0.011) in the <italic>Gene</italic>PD population. The minor allele of rs967582 was also the risk allele for PD affection or earlier onset age in the previously studied populations. This replication of association with rs967582 in a third cohort further implicates <italic>ELAVL4</italic> as a PD susceptibility gene.</p></abstract><contract-num rid="NS1">R01 NS036711-09</contract-num><contract-sponsor id="NS1">National Institute of Neurological Disorders and Stroke : NINDS</contract-sponsor></article-meta></front></pmc></record>Pour manipuler ce document sous Unix (Dilib)
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