Persistent loss of tyrosine hydroxylase immunoreactivity in the substantia nigra after neuroleptic withdrawal
Identifieur interne : 000358 ( Pmc/Corpus ); précédent : 000357; suivant : 000359Persistent loss of tyrosine hydroxylase immunoreactivity in the substantia nigra after neuroleptic withdrawal
Auteurs : M. Mazurek ; S. Savedia ; R. Bobba ; S. Garside ; P. RosebushSource :
- Journal of Neurology, Neurosurgery, and Psychiatry [ 0022-3050 ] ; 1998.
Abstract
A 37 year woman developed neuroleptic induced parkinsonism that persisted long after the drug had been discontinued. This prompted a study of the effect of an eight week course of haloperidol (HAL) followed by two week withdrawal, on dopaminergic neurons of the substantia nigra in rats. Animals treated with HAL showed a highly significant 32%-46% loss of tyrosine hydroxylase (TH) immunoreactive neurons in the substantia nigra, and 20% contraction of the TH stained dendritic arbour. Neuroleptic drug induced downregulation of nigral dopaminergic neurons may help to explain the persistent parkinsonism found in many patients after withdrawal of medication.
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PubMed: 9647315
PubMed Central: 2170106
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<record><TEI><teiHeader><fileDesc><titleStmt><title xml:lang="en">Persistent loss of tyrosine hydroxylase immunoreactivity in the
substantia nigra after neuroleptic withdrawal</title><author><name sortKey="Mazurek, M" sort="Mazurek, M" uniqKey="Mazurek M" first="M." last="Mazurek">M. Mazurek</name></author><author><name sortKey="Savedia, S" sort="Savedia, S" uniqKey="Savedia S" first="S." last="Savedia">S. Savedia</name></author><author><name sortKey="Bobba, R" sort="Bobba, R" uniqKey="Bobba R" first="R." last="Bobba">R. Bobba</name></author><author><name sortKey="Garside, S" sort="Garside, S" uniqKey="Garside S" first="S." last="Garside">S. Garside</name></author><author><name sortKey="Rosebush, P" sort="Rosebush, P" uniqKey="Rosebush P" first="P." last="Rosebush">P. Rosebush</name></author></titleStmt><publicationStmt><idno type="wicri:source">PMC</idno><idno type="pmid">9647315</idno><idno type="pmc">2170106</idno><idno type="url">http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2170106</idno><idno type="RBID">PMC:2170106</idno><date when="1998">1998</date><idno type="wicri:Area/Pmc/Corpus">000358</idno><idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Corpus" wicri:corpus="PMC">000358</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en" level="a" type="main">Persistent loss of tyrosine hydroxylase immunoreactivity in the
substantia nigra after neuroleptic withdrawal</title><author><name sortKey="Mazurek, M" sort="Mazurek, M" uniqKey="Mazurek M" first="M." last="Mazurek">M. Mazurek</name></author><author><name sortKey="Savedia, S" sort="Savedia, S" uniqKey="Savedia S" first="S." last="Savedia">S. Savedia</name></author><author><name sortKey="Bobba, R" sort="Bobba, R" uniqKey="Bobba R" first="R." last="Bobba">R. Bobba</name></author><author><name sortKey="Garside, S" sort="Garside, S" uniqKey="Garside S" first="S." last="Garside">S. Garside</name></author><author><name sortKey="Rosebush, P" sort="Rosebush, P" uniqKey="Rosebush P" first="P." last="Rosebush">P. Rosebush</name></author></analytic><series><title level="j">Journal of Neurology, Neurosurgery, and Psychiatry</title><idno type="ISSN">0022-3050</idno><idno type="eISSN">1468-330X</idno><imprint><date when="1998">1998</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en"><p>A 37 year woman developed neuroleptic induced parkinsonism that
persisted long after the drug had been discontinued. This prompted a
study of the effect of an eight week course of haloperidol (HAL)
followed by two week withdrawal, on dopaminergic neurons of the
substantia nigra in rats. Animals treated with HAL showed a highly
significant 32%-46% loss of tyrosine hydroxylase (TH) immunoreactive
neurons in the substantia nigra, and 20% contraction of the TH stained
dendritic arbour. Neuroleptic drug induced downregulation of nigral
dopaminergic neurons may help to explain the persistent parkinsonism
found in many patients after withdrawal of medication.
</p></div></front></TEI><pmc article-type="brief-report"><pmc-comment>The publisher of this article does not allow downloading of the full text in XML form.</pmc-comment>
<front><journal-meta><journal-id journal-id-type="nlm-ta">J Neurol Neurosurg Psychiatry</journal-id><journal-title>Journal of Neurology, Neurosurgery, and Psychiatry</journal-title><issn pub-type="ppub">0022-3050</issn><issn pub-type="epub">1468-330X</issn><publisher><publisher-name>BMJ Group</publisher-name></publisher></journal-meta><article-meta><article-id pub-id-type="pmid">9647315</article-id><article-id pub-id-type="pmc">2170106</article-id><article-categories><subj-group subj-group-type="heading"><subject>Short Report</subject></subj-group></article-categories><title-group><article-title>Persistent loss of tyrosine hydroxylase immunoreactivity in the
substantia nigra after neuroleptic withdrawal</article-title></title-group><contrib-group><contrib contrib-type="author"><name><surname>Mazurek</surname><given-names>M.</given-names></name></contrib><contrib contrib-type="author"><name><surname>Savedia</surname><given-names>S.</given-names></name></contrib><contrib contrib-type="author"><name><surname>Bobba</surname><given-names>R.</given-names></name></contrib><contrib contrib-type="author"><name><surname>Garside</surname><given-names>S.</given-names></name></contrib><contrib contrib-type="author"><name><surname>Rosebush</surname><given-names>P.</given-names></name></contrib></contrib-group><aff>Department of Medicine (Neurology), McMaster University Medical Centre, Hamilton, Ontario, Canada.</aff><pub-date pub-type="ppub"><month>6</month><year>1998</year></pub-date><volume>64</volume><issue>6</issue><fpage>799</fpage><lpage>801</lpage><self-uri xlink:role="pdf" xlink:type="simple" xlink:href="http://jnnp.bmj.com/cgi/reprint/64/6/799.pdf"></self-uri><self-uri xlink:role="abstract" xlink:type="simple" xlink:href="http://jnnp.bmj.com/cgi/content/abstract/64/6/799"></self-uri><self-uri xlink:role="fulltext" xlink:type="simple" xlink:href="http://jnnp.bmj.com/cgi/content/full/64/6/799"></self-uri><abstract><p>A 37 year woman developed neuroleptic induced parkinsonism that
persisted long after the drug had been discontinued. This prompted a
study of the effect of an eight week course of haloperidol (HAL)
followed by two week withdrawal, on dopaminergic neurons of the
substantia nigra in rats. Animals treated with HAL showed a highly
significant 32%-46% loss of tyrosine hydroxylase (TH) immunoreactive
neurons in the substantia nigra, and 20% contraction of the TH stained
dendritic arbour. Neuroleptic drug induced downregulation of nigral
dopaminergic neurons may help to explain the persistent parkinsonism
found in many patients after withdrawal of medication.
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