Links to Exploration step
Le document en format XML
<record><TEI><teiHeader><fileDesc><titleStmt><title xml:lang="en">The effects of a mindfulness-based lifestyle program for adults with Parkinson’s disease: a mixed methods, wait list controlled randomised control study</title><author><name sortKey="Advocat, Jenny" sort="Advocat, Jenny" uniqKey="Advocat J" first="Jenny" last="Advocat">Jenny Advocat</name><affiliation><nlm:aff id="Aff1">Southern Academic Primary Care Research Unit, School of Primary Health Care, Monash University, Bldg 1, 270 Ferntree Gully Rd, Notting Hill, Victoria 3168 Australia</nlm:aff></affiliation></author><author><name sortKey="Enticott, Joanne" sort="Enticott, Joanne" uniqKey="Enticott J" first="Joanne" last="Enticott">Joanne Enticott</name><affiliation><nlm:aff id="Aff2">Department of Psychiatry, Southern Synergy, Monash University, 126-128 Cleeland Street, Dandenong, Victoria 3175 Australia</nlm:aff></affiliation></author><author><name sortKey="Vandenberg, Brooke" sort="Vandenberg, Brooke" uniqKey="Vandenberg B" first="Brooke" last="Vandenberg">Brooke Vandenberg</name><affiliation><nlm:aff id="Aff3">School of Primary Health Care, Monash University, Bldg 1, 270 Ferntree Gully Rd, Notting Hill, Victoria 3168 Australia</nlm:aff></affiliation></author><author><name sortKey="Hassed, Craig" sort="Hassed, Craig" uniqKey="Hassed C" first="Craig" last="Hassed">Craig Hassed</name><affiliation><nlm:aff id="Aff4">Department of General Practice, School of Primary Health Care, Monash University, Bldg 1, 270 Ferntree Gully Rd, Notting Hill, Victoria 3168 Australia</nlm:aff></affiliation></author><author><name sortKey="Hester, Jennifer" sort="Hester, Jennifer" uniqKey="Hester J" first="Jennifer" last="Hester">Jennifer Hester</name><affiliation><nlm:aff id="Aff1">Southern Academic Primary Care Research Unit, School of Primary Health Care, Monash University, Bldg 1, 270 Ferntree Gully Rd, Notting Hill, Victoria 3168 Australia</nlm:aff></affiliation><affiliation><nlm:aff id="Aff6">Brotherhood of St Laurence, Melbourne, Australia</nlm:aff></affiliation></author><author><name sortKey="Russell, Grant" sort="Russell, Grant" uniqKey="Russell G" first="Grant" last="Russell">Grant Russell</name><affiliation><nlm:aff id="Aff1">Southern Academic Primary Care Research Unit, School of Primary Health Care, Monash University, Bldg 1, 270 Ferntree Gully Rd, Notting Hill, Victoria 3168 Australia</nlm:aff></affiliation><affiliation><nlm:aff id="Aff4">Department of General Practice, School of Primary Health Care, Monash University, Bldg 1, 270 Ferntree Gully Rd, Notting Hill, Victoria 3168 Australia</nlm:aff></affiliation><affiliation><nlm:aff id="Aff5">Department of Family Medicine, University of Ottawa, Ottawa, ON Canada</nlm:aff></affiliation></author></titleStmt><publicationStmt><idno type="wicri:source">PMC</idno><idno type="pmid">27608621</idno><idno type="pmc">5016929</idno><idno type="url">http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5016929</idno><idno type="RBID">PMC:5016929</idno><idno type="doi">10.1186/s12883-016-0685-1</idno><date when="2016">2016</date><idno type="wicri:Area/Pmc/Corpus">000238</idno><idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Corpus" wicri:corpus="PMC">000238</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en" level="a" type="main">The effects of a mindfulness-based lifestyle program for adults with Parkinson’s disease: a mixed methods, wait list controlled randomised control study</title><author><name sortKey="Advocat, Jenny" sort="Advocat, Jenny" uniqKey="Advocat J" first="Jenny" last="Advocat">Jenny Advocat</name><affiliation><nlm:aff id="Aff1">Southern Academic Primary Care Research Unit, School of Primary Health Care, Monash University, Bldg 1, 270 Ferntree Gully Rd, Notting Hill, Victoria 3168 Australia</nlm:aff></affiliation></author><author><name sortKey="Enticott, Joanne" sort="Enticott, Joanne" uniqKey="Enticott J" first="Joanne" last="Enticott">Joanne Enticott</name><affiliation><nlm:aff id="Aff2">Department of Psychiatry, Southern Synergy, Monash University, 126-128 Cleeland Street, Dandenong, Victoria 3175 Australia</nlm:aff></affiliation></author><author><name sortKey="Vandenberg, Brooke" sort="Vandenberg, Brooke" uniqKey="Vandenberg B" first="Brooke" last="Vandenberg">Brooke Vandenberg</name><affiliation><nlm:aff id="Aff3">School of Primary Health Care, Monash University, Bldg 1, 270 Ferntree Gully Rd, Notting Hill, Victoria 3168 Australia</nlm:aff></affiliation></author><author><name sortKey="Hassed, Craig" sort="Hassed, Craig" uniqKey="Hassed C" first="Craig" last="Hassed">Craig Hassed</name><affiliation><nlm:aff id="Aff4">Department of General Practice, School of Primary Health Care, Monash University, Bldg 1, 270 Ferntree Gully Rd, Notting Hill, Victoria 3168 Australia</nlm:aff></affiliation></author><author><name sortKey="Hester, Jennifer" sort="Hester, Jennifer" uniqKey="Hester J" first="Jennifer" last="Hester">Jennifer Hester</name><affiliation><nlm:aff id="Aff1">Southern Academic Primary Care Research Unit, School of Primary Health Care, Monash University, Bldg 1, 270 Ferntree Gully Rd, Notting Hill, Victoria 3168 Australia</nlm:aff></affiliation><affiliation><nlm:aff id="Aff6">Brotherhood of St Laurence, Melbourne, Australia</nlm:aff></affiliation></author><author><name sortKey="Russell, Grant" sort="Russell, Grant" uniqKey="Russell G" first="Grant" last="Russell">Grant Russell</name><affiliation><nlm:aff id="Aff1">Southern Academic Primary Care Research Unit, School of Primary Health Care, Monash University, Bldg 1, 270 Ferntree Gully Rd, Notting Hill, Victoria 3168 Australia</nlm:aff></affiliation><affiliation><nlm:aff id="Aff4">Department of General Practice, School of Primary Health Care, Monash University, Bldg 1, 270 Ferntree Gully Rd, Notting Hill, Victoria 3168 Australia</nlm:aff></affiliation><affiliation><nlm:aff id="Aff5">Department of Family Medicine, University of Ottawa, Ottawa, ON Canada</nlm:aff></affiliation></author></analytic><series><title level="j">BMC Neurology</title><idno type="eISSN">1471-2377</idno><imprint><date when="2016">2016</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en"><sec><title>Background</title><p>Parkinson’s disease (PD) is the second commonest neurodegenerative disease in developed countries. Current treatment for PD is pharmacologically focused and can have significant side-effects. There is increasing interest in holistic approaches including mindfulness to help manage the challenges associated with living with PD. We hypothesised that there would be an improvement in PD associated function and wellbeing in participants after participating in a 6-week mindfulness-based lifestyle program, and that these improvements would be sustainable at 6 months. Our primary objective was to determine changes in function and wellbeing associated with PD.</p></sec><sec><title>Methods</title><p>An exploratory prospective, mixed-method, randomised control trial incorporating a before and after design with a waitlist control, with an embedded qualitative component was conducted in 2012–2013. Participants included community living adults with disability congruent to H&Y Stage 2 PD, aged 18–75, fluent in spoken and written English and able to attend at least four of six sessions of the program. Participants were randomised to the intervention or wait-list control groups at two locations. All participants in the wait-list control group eventually received the intervention. Two randomisation codes were created for each location. Allocation to the intervention or wait-list control was by random number generation. The program facilitator and participants were blinded to participant data.</p></sec><sec><title>Results</title><p>Group 1 included 35 participants and group 2 (the waitlist control), 37. Data was analysed from 24 (group 1) and 33 (group 2) participants. The intervention group, compared to the waitlist control, showed a small improvement in function and wellbeing associated with PD immediately after the program (t-score = −0.59) and at 6-month post intervention (t-score = −1.42) as reported by the PDQ-39 SI. However this finding was not significant (<italic>p</italic> = 0.56 and 0.16 respectively). A small yet significant effect size (<italic>β</italic> = 0.23) in PDQ-39 ADL was reported in group 1 after 6-months post-intervention. This showed a positive improvement in the ADL as reported by group 1 after 6-months (t-score −1.8, <italic>p</italic> = 0.04). Four secondary measures are reported.</p></sec><sec><title>Conclusions</title><p>Our findings suggest mindfulness-based lifestyle programs have potential to assist participants in managing the ongoing difficulties associated with a neurological condition such as Parkinson’s disease. Importantly, our study shows promise for the long term benefits of such programs. Improvements to participant activities in daily living and mindfulness were retained at 6-months post intervention. A more definitive study should be conducted in a larger sample of PD patients to further explore these findings and their impact on reducing stress and anxiety in PD patients.</p></sec><sec><title>Trial Registration</title><p>Australian New Zealand Clinical Trials Registry (ANZCTR) <ext-link ext-link-type="uri" xlink:href="http://www.anzctr.org.au/TrialSearch.aspx?searchTxt=12612000440820&conditionCategory=&conditionCode=&interventionCodeOperator=&interventionCode=&ageGroup=&healthyVolunteers=&gender=&allocationToIntervention=&dateOfRegistrationFrom=&">ACTRN12612000440820</ext-link>, 17<sup>th</sup> April 2012.</p></sec></div></front><back><div1 type="bibliography"><listBibl><biblStruct><analytic><author><name sortKey="Kalia, Lv" uniqKey="Kalia L">LV Kalia</name></author><author><name sortKey="Lang, Ae" uniqKey="Lang A">AE Lang</name></author></analytic></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct><analytic><author><name sortKey="Pringsheim, T" uniqKey="Pringsheim T">T Pringsheim</name></author><author><name sortKey="Jette, N" uniqKey="Jette N">N Jette</name></author><author><name sortKey="Frolkis, A" uniqKey="Frolkis A">A Frolkis</name></author><author><name sortKey="Steeves, Tdl" uniqKey="Steeves T">TDL Steeves</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Van Den Eeden, Sk" uniqKey="Van Den Eeden S">SK Van Den Eeden</name></author><author><name sortKey="Tanner, Cm" uniqKey="Tanner C">CM Tanner</name></author><author><name sortKey="Bernstein, Al" uniqKey="Bernstein A">AL Bernstein</name></author><author><name sortKey="Fross, Rd" uniqKey="Fross R">RD Fross</name></author><author><name sortKey="Leimpeter, A" uniqKey="Leimpeter A">A Leimpeter</name></author><author><name sortKey="Bloch, Da" uniqKey="Bloch D">DA Bloch</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Barone, P" uniqKey="Barone P">P Barone</name></author><author><name sortKey="Antonini, A" uniqKey="Antonini A">A Antonini</name></author><author><name sortKey="Colosimo, C" uniqKey="Colosimo C">C Colosimo</name></author><author><name sortKey="Marconi, R" uniqKey="Marconi R">R Marconi</name></author><author><name sortKey="Morgante, L" uniqKey="Morgante L">L Morgante</name></author><author><name sortKey="Avarello, Tp" uniqKey="Avarello T">TP Avarello</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Schrag, A" uniqKey="Schrag A">A Schrag</name></author><author><name sortKey="Hovris, A" uniqKey="Hovris A">A Hovris</name></author><author><name sortKey="Morley, D" uniqKey="Morley D">D Morley</name></author><author><name sortKey="Quinn, N" uniqKey="Quinn N">N Quinn</name></author><author><name sortKey="Jahanshahi, M" uniqKey="Jahanshahi M">M Jahanshahi</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Ott, Mj" uniqKey="Ott M">MJ Ott</name></author><author><name sortKey="Norris, Rl" uniqKey="Norris R">RL Norris</name></author><author><name sortKey="Bauer Wu, Sm" uniqKey="Bauer Wu S">SM Bauer-Wu</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Grossman, P" uniqKey="Grossman P">P Grossman</name></author><author><name sortKey="Tiefenthaler Gilmer, U" uniqKey="Tiefenthaler Gilmer U">U Tiefenthaler-Gilmer</name></author><author><name sortKey="Raysz, A" uniqKey="Raysz A">A Raysz</name></author><author><name sortKey="Kesper, U" uniqKey="Kesper U">U Kesper</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Pradhan, Ek" uniqKey="Pradhan E">EK Pradhan</name></author><author><name sortKey="Baumgarten, M" uniqKey="Baumgarten M">M Baumgarten</name></author><author><name sortKey="Langenberg, P" uniqKey="Langenberg P">P Langenberg</name></author><author><name sortKey="Handwerger, B" uniqKey="Handwerger B">B Handwerger</name></author><author><name sortKey="Gilpin, Ak" uniqKey="Gilpin A">AK Gilpin</name></author><author><name sortKey="Magyari, T" uniqKey="Magyari T">T Magyari</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Morone, Ne" uniqKey="Morone N">NE Morone</name></author><author><name sortKey="Greco, Cm" uniqKey="Greco C">CM Greco</name></author><author><name sortKey="Weiner, Dk" uniqKey="Weiner D">DK Weiner</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Bohlmeijer, E" uniqKey="Bohlmeijer E">E Bohlmeijer</name></author><author><name sortKey="Prenger, R" uniqKey="Prenger R">R Prenger</name></author><author><name sortKey="Taal, E" uniqKey="Taal E">E Taal</name></author><author><name sortKey="Cuijpers, P" uniqKey="Cuijpers P">P Cuijpers</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Grossman, P" uniqKey="Grossman P">P Grossman</name></author><author><name sortKey="Kappos, L" uniqKey="Kappos L">L Kappos</name></author><author><name sortKey="Gensicke, H" uniqKey="Gensicke H">H Gensicke</name></author><author><name sortKey="D Souza, M" uniqKey="D Souza M">M D'Souza</name></author><author><name sortKey="Mohr, Dc" uniqKey="Mohr D">DC Mohr</name></author><author><name sortKey="Penner, Ik" uniqKey="Penner I">IK Penner</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Jelinek, G" uniqKey="Jelinek G">G Jelinek</name></author><author><name sortKey="Hassed, C" uniqKey="Hassed C">C Hassed</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Kabat Zinn, J" uniqKey="Kabat Zinn J">J Kabat-Zinn</name></author><author><name sortKey="Wheeler, E" uniqKey="Wheeler E">E Wheeler</name></author><author><name sortKey="Light, T" uniqKey="Light T">T Light</name></author><author><name sortKey="Skillings, A" uniqKey="Skillings A">A Skillings</name></author><author><name sortKey="Scharf, Mj" uniqKey="Scharf M">MJ Scharf</name></author><author><name sortKey="Cropley, Tg" uniqKey="Cropley T">TG Cropley</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Hadgkiss, Ej" uniqKey="Hadgkiss E">EJ Hadgkiss</name></author><author><name sortKey="Jelinek, Ga" uniqKey="Jelinek G">GA Jelinek</name></author><author><name sortKey="Weiland, Tj" uniqKey="Weiland T">TJ Weiland</name></author><author><name sortKey="Rumbold, G" uniqKey="Rumbold G">G Rumbold</name></author><author><name sortKey="Mackinlay, Ca" uniqKey="Mackinlay C">CA Mackinlay</name></author><author><name sortKey="Gutbrod, S" uniqKey="Gutbrod S">S Gutbrod</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Pickut, Ba" uniqKey="Pickut B">BA Pickut</name></author><author><name sortKey="Vanneste, S" uniqKey="Vanneste S">S Vanneste</name></author><author><name sortKey="Hirsch, Ma" uniqKey="Hirsch M">MA Hirsch</name></author><author><name sortKey="Van Heck, W" uniqKey="Van Heck W">W Van Heck</name></author><author><name sortKey="Kerckhofs, E" uniqKey="Kerckhofs E">E Kerckhofs</name></author><author><name sortKey="Marien, P" uniqKey="Marien P">P Marien</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Fitzpatrick, L" uniqKey="Fitzpatrick L">L Fitzpatrick</name></author><author><name sortKey="Simpson, J" uniqKey="Simpson J">J Simpson</name></author><author><name sortKey="Smith, A" uniqKey="Smith A">A Smith</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Hoehn, M" uniqKey="Hoehn M">M Hoehn</name></author><author><name sortKey="Yahr, M" uniqKey="Yahr M">M Yahr</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Advocat, J" uniqKey="Advocat J">J Advocat</name></author><author><name sortKey="Russell, G" uniqKey="Russell G">G Russell</name></author><author><name sortKey="Enticott, J" uniqKey="Enticott J">J Enticott</name></author><author><name sortKey="Hassed, C" uniqKey="Hassed C">C Hassed</name></author><author><name sortKey="Hester, J" uniqKey="Hester J">J Hester</name></author><author><name sortKey="Vandenberg, B" uniqKey="Vandenberg B">B Vandenberg</name></author></analytic></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct><analytic><author><name sortKey="Jenkinson, C" uniqKey="Jenkinson C">C Jenkinson</name></author><author><name sortKey="Fitzpatrick, R" uniqKey="Fitzpatrick R">R Fitzpatrick</name></author><author><name sortKey="Peto, V" uniqKey="Peto V">V Peto</name></author><author><name sortKey="Greenhall, R" uniqKey="Greenhall R">R Greenhall</name></author><author><name sortKey="Hyman, N" uniqKey="Hyman N">N Hyman</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Walach, H" uniqKey="Walach H">H Walach</name></author><author><name sortKey="Buchheld, N" uniqKey="Buchheld N">N Buchheld</name></author><author><name sortKey="Buttenmuller, V" uniqKey="Buttenmuller V">V Buttenmüller</name></author><author><name sortKey="Kleinknecht, N" uniqKey="Kleinknecht N">N Kleinknecht</name></author><author><name sortKey="Schmidt, S" uniqKey="Schmidt S">S Schmidt</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Lovibond, S" uniqKey="Lovibond S">S Lovibond</name></author><author><name sortKey="Lovibond, P" uniqKey="Lovibond P">P Lovibond</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Wallston, Ka" uniqKey="Wallston K">KA Wallston</name></author></analytic></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct><analytic><author><name sortKey="Cohen, J" uniqKey="Cohen J">J Cohen</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Lovibond, Pf" uniqKey="Lovibond P">PF Lovibond</name></author><author><name sortKey="Lovibond, Sh" uniqKey="Lovibond S">SH Lovibond</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Mohr, B" uniqKey="Mohr B">B Mohr</name></author><author><name sortKey="Muller, V" uniqKey="Muller V">V Müller</name></author><author><name sortKey="Mattes, R" uniqKey="Mattes R">R Mattes</name></author><author><name sortKey="Rosin, R" uniqKey="Rosin R">R Rosin</name></author><author><name sortKey="Federmann, B" uniqKey="Federmann B">B Federmann</name></author><author><name sortKey="Strehl, U" uniqKey="Strehl U">U Strehl</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Payne, Ja" uniqKey="Payne J">JA Payne</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Schreurs, Kmg" uniqKey="Schreurs K">KMG Schreurs</name></author><author><name sortKey="De Ridder, Dtd" uniqKey="De Ridder D">DTD De Ridder</name></author><author><name sortKey="Bensing, Jm" uniqKey="Bensing J">JM Bensing</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Olanow, Cw" uniqKey="Olanow C">CW Olanow</name></author><author><name sortKey="Watts, Rl" uniqKey="Watts R">RL Watts</name></author><author><name sortKey="Koller, Wc" uniqKey="Koller W">WC Koller</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Cairns, V" uniqKey="Cairns V">V Cairns</name></author><author><name sortKey="Murray, C" uniqKey="Murray C">C Murray</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Bega, D" uniqKey="Bega D">D Bega</name></author><author><name sortKey="Zadikoff, C" uniqKey="Zadikoff C">C Zadikoff</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Gruber Baldini, Al" uniqKey="Gruber Baldini A">AL Gruber-Baldini</name></author><author><name sortKey="Ye, J" uniqKey="Ye J">J Ye</name></author><author><name sortKey="Anderson, Ke" uniqKey="Anderson K">KE Anderson</name></author><author><name sortKey="Shulman, Lm" uniqKey="Shulman L">LM Shulman</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Tang, Yy" uniqKey="Tang Y">YY Tang</name></author><author><name sortKey="Holzel, Bk" uniqKey="Holzel B">BK Holzel</name></author><author><name sortKey="Posner, Mi" uniqKey="Posner M">MI Posner</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Pickut, Ba" uniqKey="Pickut B">BA Pickut</name></author><author><name sortKey="Van Hecke, W" uniqKey="Van Hecke W">W Van Hecke</name></author><author><name sortKey="Kerckhofs, E" uniqKey="Kerckhofs E">E Kerckhofs</name></author><author><name sortKey="Marien, P" uniqKey="Marien P">P Marien</name></author><author><name sortKey="Vanneste, S" uniqKey="Vanneste S">S Vanneste</name></author><author><name sortKey="Cras, P" uniqKey="Cras P">P Cras</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Ma, Sh" uniqKey="Ma S">SH Ma</name></author><author><name sortKey="Teasdale, Jd" uniqKey="Teasdale J">JD Teasdale</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Grossman, P" uniqKey="Grossman P">P Grossman</name></author><author><name sortKey="Niemann, L" uniqKey="Niemann L">L Niemann</name></author><author><name sortKey="Schmidt, S" uniqKey="Schmidt S">S Schmidt</name></author><author><name sortKey="Walach, H" uniqKey="Walach H">H Walach</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Allen, Nb" uniqKey="Allen N">NB Allen</name></author><author><name sortKey="Chambers, R" uniqKey="Chambers R">R Chambers</name></author><author><name sortKey="Knight, W" uniqKey="Knight W">W Knight</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Souza, Rg" uniqKey="Souza R">RG Souza</name></author><author><name sortKey="Borges, V" uniqKey="Borges V">V Borges</name></author><author><name sortKey="Silva, Smcda" uniqKey="Silva S">SMCdA Silva</name></author><author><name sortKey="Ferraz, Hb" uniqKey="Ferraz H">HB Ferraz</name></author></analytic></biblStruct><biblStruct></biblStruct><biblStruct><analytic><author><name sortKey="Murman, Dl" uniqKey="Murman D">DL Murman</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Crane, C" uniqKey="Crane C">C Crane</name></author><author><name sortKey="Crane, Rs" uniqKey="Crane R">RS Crane</name></author><author><name sortKey="Eames, C" uniqKey="Eames C">C Eames</name></author><author><name sortKey="Fennell, Mjv" uniqKey="Fennell M">MJV Fennell</name></author><author><name sortKey="Silverton, S" uniqKey="Silverton S">S Silverton</name></author><author><name sortKey="Williams, Jmg" uniqKey="Williams J">JMG Williams</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Nyklicek, I" uniqKey="Nyklicek I">I Nyklicek</name></author><author><name sortKey="Kuijpers, Kf" uniqKey="Kuijpers K">KF Kuijpers</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Carmody, J" uniqKey="Carmody J">J Carmody</name></author><author><name sortKey="Baer, Ra" uniqKey="Baer R">RA Baer</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Cash, T" uniqKey="Cash T">T Cash</name></author><author><name sortKey="Ekouevi, V" uniqKey="Ekouevi V">V Ekouevi</name></author><author><name sortKey="Kilbourn, C" uniqKey="Kilbourn C">C Kilbourn</name></author><author><name sortKey="Lageman, S" uniqKey="Lageman S">S Lageman</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Delgado Rodriguez, M" uniqKey="Delgado Rodriguez M">M Delgado-Rodríguez</name></author><author><name sortKey="Llorca, J" uniqKey="Llorca J">J Llorca</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Jenkinson, C" uniqKey="Jenkinson C">C Jenkinson</name></author><author><name sortKey="Fitzpatrick, R" uniqKey="Fitzpatrick R">R Fitzpatrick</name></author><author><name sortKey="Peto, V" uniqKey="Peto V">V Peto</name></author><author><name sortKey="Harris, R" uniqKey="Harris R">R Harris</name></author><author><name sortKey="Saunders, P" uniqKey="Saunders P">P Saunders</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Kim, M" uniqKey="Kim M">M Kim</name></author><author><name sortKey="Dahlberg, A" uniqKey="Dahlberg A">A Dahlberg</name></author><author><name sortKey="Hagell, P" uniqKey="Hagell P">P Hagell</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Johnson, Ar" uniqKey="Johnson A">AR Johnson</name></author><author><name sortKey="Lawrence, Bj" uniqKey="Lawrence B">BJ Lawrence</name></author><author><name sortKey="Corti, Ej" uniqKey="Corti E">EJ Corti</name></author><author><name sortKey="Booth, L" uniqKey="Booth L">L Booth</name></author><author><name sortKey="Gasson, N" uniqKey="Gasson N">N Gasson</name></author><author><name sortKey="Thomas, Mg" uniqKey="Thomas M">MG Thomas</name></author></analytic></biblStruct></listBibl></div1></back></TEI><pmc article-type="research-article"><pmc-dir>properties open_access</pmc-dir>
<front><journal-meta><journal-id journal-id-type="nlm-ta">BMC Neurol</journal-id><journal-id journal-id-type="iso-abbrev">BMC Neurol</journal-id><journal-title-group><journal-title>BMC Neurology</journal-title></journal-title-group><issn pub-type="epub">1471-2377</issn><publisher><publisher-name>BioMed Central</publisher-name><publisher-loc>London</publisher-loc></publisher></journal-meta><article-meta><article-id pub-id-type="pmid">27608621</article-id><article-id pub-id-type="pmc">5016929</article-id><article-id pub-id-type="publisher-id">685</article-id><article-id pub-id-type="doi">10.1186/s12883-016-0685-1</article-id><article-categories><subj-group subj-group-type="heading"><subject>Research Article</subject></subj-group></article-categories><title-group><article-title>The effects of a mindfulness-based lifestyle program for adults with Parkinson’s disease: a mixed methods, wait list controlled randomised control study</article-title></title-group><contrib-group><contrib contrib-type="author" corresp="yes"><name><surname>Advocat</surname><given-names>Jenny</given-names></name><address><email>jenny.advocat@monash.edu</email></address><xref ref-type="aff" rid="Aff1">1</xref></contrib><contrib contrib-type="author"><name><surname>Enticott</surname><given-names>Joanne</given-names></name><address><email>Joanne.Enticott@monash.edu</email></address><xref ref-type="aff" rid="Aff2">2</xref></contrib><contrib contrib-type="author"><name><surname>Vandenberg</surname><given-names>Brooke</given-names></name><address><email>brooke.vandenberg@monash.edu</email></address><xref ref-type="aff" rid="Aff3">3</xref></contrib><contrib contrib-type="author"><name><surname>Hassed</surname><given-names>Craig</given-names></name><address><email>craig.hassed@monash.edu</email></address><xref ref-type="aff" rid="Aff4">4</xref></contrib><contrib contrib-type="author"><name><surname>Hester</surname><given-names>Jennifer</given-names></name><address><email>Jennifer.Hester@bsl.org.au</email></address><xref ref-type="aff" rid="Aff1">1</xref><xref ref-type="aff" rid="Aff6">6</xref></contrib><contrib contrib-type="author"><name><surname>Russell</surname><given-names>Grant</given-names></name><address><email>grant.russell@monash.edu</email></address><xref ref-type="aff" rid="Aff1">1</xref><xref ref-type="aff" rid="Aff4">4</xref><xref ref-type="aff" rid="Aff5">5</xref></contrib><aff id="Aff1"><label>1</label>Southern Academic Primary Care Research Unit, School of Primary Health Care, Monash University, Bldg 1, 270 Ferntree Gully Rd, Notting Hill, Victoria 3168 Australia</aff><aff id="Aff2"><label>2</label>Department of Psychiatry, Southern Synergy, Monash University, 126-128 Cleeland Street, Dandenong, Victoria 3175 Australia</aff><aff id="Aff3"><label>3</label>School of Primary Health Care, Monash University, Bldg 1, 270 Ferntree Gully Rd, Notting Hill, Victoria 3168 Australia</aff><aff id="Aff4"><label>4</label>Department of General Practice, School of Primary Health Care, Monash University, Bldg 1, 270 Ferntree Gully Rd, Notting Hill, Victoria 3168 Australia</aff><aff id="Aff5"><label>5</label>Department of Family Medicine, University of Ottawa, Ottawa, ON Canada</aff><aff id="Aff6"><label>6</label>Brotherhood of St Laurence, Melbourne, Australia</aff></contrib-group><pub-date pub-type="epub"><day>8</day><month>9</month><year>2016</year></pub-date><pub-date pub-type="pmc-release"><day>8</day><month>9</month><year>2016</year></pub-date><pub-date pub-type="collection"><year>2016</year></pub-date><volume>16</volume><issue>1</issue><elocation-id>166</elocation-id><history><date date-type="received"><day>19</day><month>1</month><year>2016</year></date><date date-type="accepted"><day>29</day><month>8</month><year>2016</year></date></history><permissions><copyright-statement>© The Author(s). 2016</copyright-statement><license license-type="OpenAccess"><license-p><bold>Open Access</bold>This article is distributed under the terms of the Creative Commons Attribution 4.0 International License (<ext-link ext-link-type="uri" xlink:href="http://creativecommons.org/licenses/by/4.0/">http://creativecommons.org/licenses/by/4.0/</ext-link>), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (<ext-link ext-link-type="uri" xlink:href="http://creativecommons.org/publicdomain/zero/1.0/">http://creativecommons.org/publicdomain/zero/1.0/</ext-link>) applies to the data made available in this article, unless otherwise stated.</license-p></license></permissions><abstract id="Abs1"><sec><title>Background</title><p>Parkinson’s disease (PD) is the second commonest neurodegenerative disease in developed countries. Current treatment for PD is pharmacologically focused and can have significant side-effects. There is increasing interest in holistic approaches including mindfulness to help manage the challenges associated with living with PD. We hypothesised that there would be an improvement in PD associated function and wellbeing in participants after participating in a 6-week mindfulness-based lifestyle program, and that these improvements would be sustainable at 6 months. Our primary objective was to determine changes in function and wellbeing associated with PD.</p></sec><sec><title>Methods</title><p>An exploratory prospective, mixed-method, randomised control trial incorporating a before and after design with a waitlist control, with an embedded qualitative component was conducted in 2012–2013. Participants included community living adults with disability congruent to H&Y Stage 2 PD, aged 18–75, fluent in spoken and written English and able to attend at least four of six sessions of the program. Participants were randomised to the intervention or wait-list control groups at two locations. All participants in the wait-list control group eventually received the intervention. Two randomisation codes were created for each location. Allocation to the intervention or wait-list control was by random number generation. The program facilitator and participants were blinded to participant data.</p></sec><sec><title>Results</title><p>Group 1 included 35 participants and group 2 (the waitlist control), 37. Data was analysed from 24 (group 1) and 33 (group 2) participants. The intervention group, compared to the waitlist control, showed a small improvement in function and wellbeing associated with PD immediately after the program (t-score = −0.59) and at 6-month post intervention (t-score = −1.42) as reported by the PDQ-39 SI. However this finding was not significant (<italic>p</italic> = 0.56 and 0.16 respectively). A small yet significant effect size (<italic>β</italic> = 0.23) in PDQ-39 ADL was reported in group 1 after 6-months post-intervention. This showed a positive improvement in the ADL as reported by group 1 after 6-months (t-score −1.8, <italic>p</italic> = 0.04). Four secondary measures are reported.</p></sec><sec><title>Conclusions</title><p>Our findings suggest mindfulness-based lifestyle programs have potential to assist participants in managing the ongoing difficulties associated with a neurological condition such as Parkinson’s disease. Importantly, our study shows promise for the long term benefits of such programs. Improvements to participant activities in daily living and mindfulness were retained at 6-months post intervention. A more definitive study should be conducted in a larger sample of PD patients to further explore these findings and their impact on reducing stress and anxiety in PD patients.</p></sec><sec><title>Trial Registration</title><p>Australian New Zealand Clinical Trials Registry (ANZCTR) <ext-link ext-link-type="uri" xlink:href="http://www.anzctr.org.au/TrialSearch.aspx?searchTxt=12612000440820&conditionCategory=&conditionCode=&interventionCodeOperator=&interventionCode=&ageGroup=&healthyVolunteers=&gender=&allocationToIntervention=&dateOfRegistrationFrom=&">ACTRN12612000440820</ext-link>, 17<sup>th</sup> April 2012.</p></sec></abstract><kwd-group xml:lang="en"><title>Keywords</title><kwd>Parkinson’s disease</kwd><kwd>Neurological disorder</kwd><kwd>Mindfulness</kwd><kwd>Group program</kwd><kwd>Meditation</kwd></kwd-group><funding-group><award-group><funding-source><institution>Parkinson's Victoria</institution></funding-source></award-group></funding-group><custom-meta-group><custom-meta><meta-name>issue-copyright-statement</meta-name><meta-value>© The Author(s) 2016</meta-value></custom-meta></custom-meta-group></article-meta></front><body><sec id="Sec1"><title>Background</title><p>Parkinson’s disease (PD) is the second commonest neurodegenerative disease in developed countries. [<xref ref-type="bibr" rid="CR1">1</xref>]. When adjusted by age, global incidence rates of PD range between 9.7 and 13.8 per 100,000 population [<xref ref-type="bibr" rid="CR2">2</xref>]. In 2014 there were nearly 70,000 people living with PD in Australia, approximately 14,500 more than in 2005, and 5,100 more than in 2011 [<xref ref-type="bibr" rid="CR3">3</xref>]. With many developed countries reporting increased ageing populations, the incidence of PD is expected to increase [<xref ref-type="bibr" rid="CR4">4</xref>, <xref ref-type="bibr" rid="CR5">5</xref>]. Despite this recognition, many diagnosed with PD continue to suffer poor quality of life, experiencing complex motor and non-motor symptoms affecting emotional, cognitive and physical well-being [<xref ref-type="bibr" rid="CR6">6</xref>].</p><p>Where PD is poorly self-managed, symptoms can lead to significant challenges in completing basic daily activities. Negative outcomes for people diagnosed with PD extend beyond the individual or patient level. Large proportions of the burden of disease are carried by those who care for PD sufferers and economically by health-systems [<xref ref-type="bibr" rid="CR2">2</xref>, <xref ref-type="bibr" rid="CR7">7</xref>]. These effects can be intensified by complex and, at times, invasive treatment options. Lifestyle-based interventions, incorporating mindfulness training, have been identified as improving self-management outcomes in patients with a variety of chronic [<xref ref-type="bibr" rid="CR8">8</xref>–<xref ref-type="bibr" rid="CR12">12</xref>] and neurological diseases [<xref ref-type="bibr" rid="CR13">13</xref>, <xref ref-type="bibr" rid="CR14">14</xref>].</p><p>Mindfulness is a form of meditation that has been defined as: “<italic>the awareness that emerges through paying attention on purpose, in the present moment, and nonjudgmentally to the unfolding of experience moment by moment</italic>” [<xref ref-type="bibr" rid="CR15">15</xref>]. One program for multiple sclerosis, utilising lifestyle and mindfulness training in conjunction with conventional medical care, found reduced costs of disease, reversal of disease progression and improvement in patient quality of life [<xref ref-type="bibr" rid="CR16">16</xref>]. Meta-analyses also suggest longer term improvements in patient mental health [<xref ref-type="bibr" rid="CR12">12</xref>]. In more recent years, programs encompassing mindfulness have begun to explore the neurobehavioral effects for people living with PD, with positive outcomes, including improved motor function, patient experience of pain [<xref ref-type="bibr" rid="CR17">17</xref>] and development of better coping mechanisms [<xref ref-type="bibr" rid="CR18">18</xref>]. The longitudinal benefit of such programs on the self-management of PD however, to the best of our knowledge, has not yet been explored.</p><p>This study aimed to investigate the impact of a 6 week mindfulness-based lifestyle program for community living adults with Hoehn and Yahr (H&Y) stage two PD [<xref ref-type="bibr" rid="CR19">19</xref>]. Our primary objective was to determine changes in function and wellbeing associated with PD. Secondary objectives were changes in health behaviours, mental health, and locus of control.</p><p>We hypothesised that there would be an improvement in PD associated function and wellbeing in participants after participating a 6 week mindfulness-based lifestyle program and that these improvements would be sustainable at 6 months.</p></sec><sec id="Sec2"><title>Methods</title><sec id="Sec3"><title>Study design</title><p>The study was an exploratory prospective, mixed-method, randomised clinical trial incorporating before and after design with a waitlist control, with an embedded qualitative component. The current paper presents the study’s quantitative data and findings. Qualitative findings will be reported separately. The intervention was participation in a 6-week mindfulness-based lifestyle program. All participants in the wait-list control group eventually received the intervention, but only after the intervention group. The study was conducted over 12 months between 2012 and 2013. A detailed description of the methodology has been previously published [<xref ref-type="bibr" rid="CR20">20</xref>].</p></sec><sec id="Sec4"><title>Advisory Group</title><p>An expert advisory group was formed to provide advice on recruitment and link clinicians and researchers. Apart from contributions to the Advisory Group, the funding body, Parkinson’s Victoria (PV), had no other involvement in the decisions and procedure concerning data collection, analysis, interpretation and academic dissemination.</p></sec><sec id="Sec5"><title>Setting</title><p>The intervention was delivered at two venues, located in two different inner-urban suburbs of Melbourne, Australia. Melbourne is a capital city in Australia with over four million people. In Australia, there are approximately 80,000 people living with Parkinson’s. In Victoria, more than 2,225 people are newly diagnosed with Parkinson’s every year [<xref ref-type="bibr" rid="CR21">21</xref>]. The suburbs chosen for the study were located close to Parkinson’s Victoria meeting group sites.</p></sec><sec id="Sec6"><title>Participants</title><p>The intervention group were participants attending the first 6-week mindfulness-based lifestyle program at each location. The control participants were those on a wait-list control group at each location. All the control participants were invited to attend the same program held at each site, but only after the intervention participants had completed the program.</p><p>Eligibility criteria were:<list list-type="bullet"><list-item><p>Between the ages of 18 and 70 at the time of recruitment</p></list-item><list-item><p>Fluent in spoken and written English</p></list-item><list-item><p>Able to attend at least four of six sessions of the mindfulness-based lifestyle program</p></list-item><list-item><p>Community living adults with disability congruent H&Y Stage 2 PD [<xref ref-type="bibr" rid="CR19">19</xref>]. This staging, for the purposes of the study, was determined by screening participants using the two below questions developed in conjunction with a neurologist. To be eligible, participants had to answer ‘yes’ to both questions:<list list-type="bullet"><list-item><p>○ ‘Do you have problems of shaking (tremor), stiffness or difficulty with movements on both sides of your body?’</p></list-item><list-item><p>○ ‘Most of the time, can you walk straight and stand up without assistance?’</p></list-item></list></p></list-item></list></p></sec><sec id="Sec7"><title>Recruitment</title><p>Volunteer participants were recruited from the PD community residing in metropolitan Melbourne. Target participants were initially invited to participate through a combination of written invitations from Parkinson’s Victoria sent to people listed on the Parkinson’s registry, advertisements in PV publications and through neurologists and primary care clinicians. In order to assist with the potential issue of slow recruitment, as seen in previous trials [<xref ref-type="bibr" rid="CR22">22</xref>], a recruitment officer (BV) was employed. The recruitment officer worked with the Advisory Group to develop additional recruitment strategies, including: the development of promotional materials (flyers, brochures, and posters), engaging with PD support groups, presenting at PD community events and utilising the M.J. Fox Foundations clinical trial finder [<xref ref-type="bibr" rid="CR23">23</xref>].</p></sec><sec id="Sec8"><title>Intervention</title><p>The intervention was a mindfulness-based lifestyle program involving facilitated, two hour group sessions once a week for a total of 6-weeks. The program was designed to introduce key lifestyle and mindfulness elements to participants. Typically, each session consisted of a 5–20 min mindfulness practice, led by the program facilitator and author of the model (CH), introduction to one of the ESSENCE elements (Fig. <xref rid="Fig1" ref-type="fig">1</xref>) and an open group discussion about participants’ thoughts and feelings about the program. The mindfulness practice included specific techniques, such as, attention to the breath, a ‘body scan’ and letting go of competing or negative thoughts. Participants were further introduced to strategies designed to help them to live better with a chronic disease and encouraged to use aspects of the program that were most relevant to them.<fig id="Fig1"><label>Fig. 1</label><caption><p>ESSENCE</p></caption><graphic xlink:href="12883_2016_685_Fig1_HTML" id="MO1"></graphic></fig></p><p>A 3 disc CD pack with guided mindfulness practices free-of-charge and printed information was given to participants to assist them with their practice outside of the group sessions. Participants were expected to continue their usual medical management and monitoring by their general practitioners and specialists.</p><p>Each intervention session was 2 h long and attended by a research assistant (BV) in addition to the course facilitator (CH). The research assistant was responsible for completing the attendance role, collecting observational data (discussed further below) and preparing the morning or afternoon tea.</p></sec><sec id="Sec9"><title>Data collection</title><sec id="Sec10"><title>Quantitative data</title><p>The primary outcome is the change in function and well-being associated with PD, measured by the validated Parkinson’s disease Questionnaire (PDQ-39) [<xref ref-type="bibr" rid="CR24">24</xref>], which captures information about PD-related symptoms and wellbeing. The questionnaire has 39 items each on a scale of 0 (never) to 5 (always or cannot do at all). Eight dimensions are reported: mobility (MOB) (10 items), activities of daily living (ADL) (6 items), emotional wellbeing (EMO) (6 items), stigma (STI) (4 items), social support (SOC) (3 items), cognitions (COG) (4 items), communication (COM) (3 items), and bodily discomfort (BOD) (3 items). A summary index score (PDQ-39-SI) provides an overall picture of health-related-quality-of-life (HRQoL).</p><p>Secondary outcomes are changes in health behaviours, mental health and locus of control measured by four validated, self-administered questionnaires. 1. mindfulness as measured by the Freiburg Mindfulness Inventory (FMI) [<xref ref-type="bibr" rid="CR25">25</xref>], 2. depression, anxiety and stress as measured by the DASS 21 [<xref ref-type="bibr" rid="CR26">26</xref>], 3. locus of control as measured using the multidimensional locus of control (LOC), Form B [<xref ref-type="bibr" rid="CR27">27</xref>], and 4. exercise and nutrition as measured in the Health Behaviours Questionnaire (HBQ)) [<xref ref-type="bibr" rid="CR28">28</xref>].</p><p>All participants completed the study questionnaires at three time points: (T0) baseline, (T1) week 7 after the intervention participants (but not wait-list controls) had completed the intervention and (T2) 6 months after the intervention had completed for all participants (both intervention and wait-list controls).</p><p>Study questionnaires were mailed or given to participants in person. Questionnaire packages included a self-addressed return envelope, cover letter with contact details for the researchers and a request that questionnaires be completed and returned within 1 week. Baseline (T0) questionnaires were mailed to all participants. At this time, participants were also emailed a link to an electronic instructional video, detailing each component of the questionnaire. Week 7 (T1) questionnaires were distributed to the intervention participants after the final session and if a participant was absent then the questionnaire was mailed. Wait-list control participants received the questionnaire in the mail. The 6 month (T2) questionnaires were all mailed. Follow up strategies were implemented if a survey was not returned within 2 week of the sent date, consisting of phone calls and emails to the participant made by a research assistant. Follow up was ceased at 4 weeks post sent date.</p></sec><sec id="Sec11"><title>Other quantitative data</title><p>We monitored participant attendance at the weekly intervention sessions. If a participant did not attend four or more sessions, this was recorded and their data excluded from the analysis. We also monitored participant adherence using a modified medical outcomes study [<xref ref-type="bibr" rid="CR29">29</xref>] and by participants self-rating their practice of the program exercises in the week prior on a 5-point Likert scale. Intervention participants were required to complete the adherence measure prior to leaving the fourth and final sessions. All participants were mailed the adherence measure along with the other study questionnaires at the 6-month post intervention point.</p></sec></sec><sec id="Sec12"><title>Sample size</title><p>In order to detect a change in the primary outcome measure of PDQ-39 having a change degree consistent with a medium-to-large effect in this study, a sample size of 80 participants was needed. This calculation assumed a dropout rate of 25 %, which is similar to rates experienced by other studies involving participants with PD [<xref ref-type="bibr" rid="CR22">22</xref>]. See the protocol paper for more information about the power and sample size calculations [<xref ref-type="bibr" rid="CR20">20</xref>].</p></sec><sec id="Sec13"><title>Randomisation</title><p>Participants were randomised to either the intervention or wait-list control groups at each location a week prior to commencement of the first programme. Two randomisation codes were created for each location. Allocation to the intervention or wait-list control was by random number generation (<ext-link ext-link-type="uri" xlink:href="http://www.randomizer.org">www.randomizer.org</ext-link>) using the permuted four block method.</p></sec><sec id="Sec14"><title>Blinding</title><p>The programme facilitator (CH) and participants were blinded to all participant data.</p></sec><sec id="Sec15"><title>Analysis</title><sec id="Sec16"><title>Quantitative data</title><p>At the 7-week data collection time point, intervention participants had completed the 6-week intervention but the wait-list controls had not; therefore analysis at this stage followed that of a standard two group RCT. This study used the baseline and 7-week data points and paired t-tests to examine differences in the outcome measures. At the 6-month data collection point, all participants in both groups had completed the intervention; therefore we did a before and after paired data analysis using baseline and 6-month data points to examine any long-term differences in the outcome measures. Effect size for the difference between the two groups was calculated using the t-statistic from the <italic>t</italic>-test using the pooled variance of the variables [<xref ref-type="bibr" rid="CR30">30</xref>].</p><p>Additionally, outcomes of the programme were correlated with participant scores for adherence using Pearson’s regression. We set a significance level of alpha = 0.05 for all outcomes in this exploratory study in order to identify any trends in the results.</p></sec></sec><sec id="Sec17"><title>Standard protocol, approvals, registration and patient consents</title><p>The study was approved the Monash University Human Research Ethics Committee project number CF11/2662-2011001553 and registered with the Australian and New Zealand Clinical Trial Register at <ext-link ext-link-type="uri" xlink:href="http://www.anzctr.org.au/">http://www.anzctr.org.au/</ext-link>, ACTRN12612000440820, 17<sup>th</sup> April 2012. All participants provided written informed consent prior to study involvement.</p></sec></sec><sec id="Sec18"><title>Results</title><p>Initial study eligibility criteria included an age limit for participants of 18–70 years. At the recommendation of the Advisory Group, the upper age limit was raised to 75 years to maximise recruitment and improve study power. Eighty-five participants were initially recruited. Twelve declined to participate, one was unavailable at the time of the study. Of the 72 randomised and invited to attend a session, 57 participants completed the intervention and 23 participants contributed to study data at 6-months (Fig. <xref rid="Fig2" ref-type="fig">2</xref>). At baseline the intervention and wait-list control groups were similar with regard to most demographic characteristics and baseline outcomes (Tables <xref rid="Tab1" ref-type="table">1</xref> and <xref rid="Tab2" ref-type="table">2</xref>).<fig id="Fig2"><label>Fig. 2</label><caption><p>Flow of participants</p></caption><graphic xlink:href="12883_2016_685_Fig2_HTML" id="MO2"></graphic></fig><table-wrap id="Tab1"><label>Table 1</label><caption><p>Baseline characteristics of ESSENCE participants</p></caption><table frame="hsides" rules="groups"><thead><tr><th colspan="2">Baseline characteristics of ESSENCE participants</th><th>Intervention group</th><th>Wait-list control group</th><th>Total (<italic>n</italic> = 57)</th></tr></thead><tbody><tr><td>Gender</td><td>Female, % (<italic>n</italic>)</td><td>66.7 % (16)</td><td>51.5 % (17)</td><td>57.9 % (33)</td></tr><tr><td rowspan="2">Age</td><td>Age year, mean (sd)</td><td>62.8 % (7.6)</td><td>63.7 % (8.6)</td><td>63.3 (8.1)</td></tr><tr><td>range</td><td>46–74</td><td>39–75</td><td>39–75</td></tr><tr><td rowspan="2">PD onset</td><td>Age at onset, mean (sd)</td><td>55.8 % (8.8)</td><td>55.1 % (10.5)</td><td>55.7 (9.9)</td></tr><tr><td>range</td><td>37–70</td><td>33–73</td><td>33–73</td></tr><tr><td>Current smoker</td><td>yes, % (<italic>n</italic>)</td><td>0 % (0)</td><td>6.1 % (2)</td><td>3.5 % (2)</td></tr><tr><td rowspan="2">Site</td><td>Camberwell, % (<italic>n</italic>)</td><td>70.8 % (17)</td><td>69.7 % (23)</td><td>70.2 % (41)</td></tr><tr><td>Essendon, % (<italic>n</italic>)</td><td>26.2 % (7)</td><td>30.3 % (10)</td><td>29.8 % (17)</td></tr><tr><td>COB</td><td>Born in Australia, % (<italic>n</italic>)</td><td>67 % (16)</td><td>79 % (26)</td><td>74 % (42)</td></tr><tr><td>Marital status</td><td>Married/defacto, % (<italic>n</italic>)</td><td>71 % (17)</td><td>79 % (26)</td><td>75 % (43)</td></tr><tr><td>Education</td><td>Above secondary school, % (<italic>n</italic>)</td><td>67 % (16)</td><td>85 % (28)</td><td>77 % (44)</td></tr></tbody></table></table-wrap><table-wrap id="Tab2"><label>Table 2</label><caption><p>Main outcome summary. Group 1 received the intervention first and Group 2 was the waitlist control. Group 2 received the intervention after the 7-week measures were collected</p></caption><table frame="hsides" rules="groups"><thead><tr><th rowspan="2" colspan="2">OutcomeS</th><th rowspan="2">Group</th><th rowspan="2">Baseline level, mean (SD)</th><th rowspan="2">7-week change (95 % CI)</th><th rowspan="2">6-Month follow-up change (95 % CI)</th><th colspan="3">7-week effects (change comparison between groups)</th><th colspan="3">6-Month follow-up effects (change from pre-intervention all individuals)</th></tr><tr><th>t</th><th><italic>p</italic> Value</th><th>Effect size</th><th>t</th><th><italic>p</italic> Value</th><th>Effect size</th></tr></thead><tbody><tr><td rowspan="4">Parkinson’s symptoms</td><td rowspan="2">PDQ39-SI</td><td>Intervention group</td><td>22.2 (12.4)</td><td>−0.54 (−3.41 to 2.32)</td><td>−0.89 (−3.71 to 1.93)</td><td rowspan="2">−0.59</td><td rowspan="2"></td><td rowspan="2">-</td><td rowspan="2">−1.42</td><td rowspan="2">0.16</td><td rowspan="2">-</td></tr><tr><td>Wait-list control</td><td>26.8 (17.5)</td><td>−1.53 (−3.64 to 0.57)</td><td>−2.54 (−6.76 to 1.67)</td></tr><tr><td rowspan="2">PDQ39-ADL</td><td>Intervention group</td><td>20.8 (14.6)</td><td>−2.43 (−8.11 to 3.25)</td><td>−2.54 (−6.87 to 1.80)</td><td rowspan="2">0.15</td><td rowspan="2">0.89</td><td rowspan="2">-</td><td rowspan="2">−1.80</td><td rowspan="2">0.04 <sup>b,a</sup></td><td rowspan="2">0.23<sup>b</sup> (small)</td></tr><tr><td>Wait-list control</td><td>26.9 (23.6)</td><td>−2.02 (−4.66 to 0.62)</td><td>−4.17(−10.75 to 2.42)</td></tr><tr><td rowspan="2">Mindfulness</td><td rowspan="2">FMI</td><td>Intervention group</td><td>37.1 (8.2)</td><td>4.88 (1.95 to 7.80)<sup>a</sup></td><td>0.95 (−1.91 to 3.82)</td><td rowspan="2">−3.02</td><td rowspan="2"><0.01<sup>a</sup></td><td rowspan="2">0.61 (medium)</td><td rowspan="2">2.35</td><td rowspan="2">0.02<sup>a</sup></td><td rowspan="2">0.32 (small)</td></tr><tr><td>Wait-list control</td><td>34.5 (8.8)</td><td>−1.06 (−3.81 to 1.68)</td><td>4.74 (0.67 to 8.81)</td></tr><tr><td rowspan="6">Depression (D)<break></break>Anxiety (A)<break></break>Stress (S)</td><td rowspan="2">DASS-D</td><td>Intervention group</td><td>4.50 (5.22)</td><td>1.92 (0.201 to 3.63)<sup>a</sup></td><td>0.78 (−0.90 to 2.47)</td><td rowspan="2">−0.66</td><td rowspan="2">0.51</td><td rowspan="2">-</td><td rowspan="2">−0.62</td><td rowspan="2">0.54</td><td rowspan="2">-</td></tr><tr><td>Wait-list control</td><td>7.19 (7.83)</td><td>1.06 (−0.84 to 2.97)</td><td>−1.75 (−4.63 to 1.13)</td></tr><tr><td rowspan="2">DASS-A</td><td>Intervention group</td><td>7.58 (4.79)</td><td>0.33 (−1.67 to 2.34)</td><td>−0.26 (−1.79 to 1.27)</td><td rowspan="2">−0.62</td><td rowspan="2">0.54</td><td rowspan="2">-</td><td rowspan="2">−0.89</td><td rowspan="2">0.38</td><td rowspan="2">-</td></tr><tr><td>Wait-list control</td><td>9.81 (7.56)</td><td>−0.63 (−2.92 to 1.67)</td><td>−0.92 (−3.21 to 1.38)</td></tr><tr><td rowspan="2">DASS-S</td><td>Intervention group</td><td>8.78 (6.35)</td><td>2.17 (0.12 to 4.23)<sup>a</sup></td><td>−1.0 (−2.89 to 0.89)</td><td rowspan="2">−2.61</td><td rowspan="2">0.01<sup>a</sup></td><td rowspan="2">0.32 (small)</td><td rowspan="2">−1.80</td><td rowspan="2">0.04 <sup>b,a</sup></td><td rowspan="2">0.27<sup>b</sup> (small)</td></tr><tr><td>Wait-list control</td><td>12.44 (9.65)</td><td>−1.63 (−3.68 to 0.43)</td><td>−1.42 (−3.58 to 0.75)</td></tr><tr><td rowspan="8">Locus of control:<break></break>Internal (I)<break></break>Chance (C)<break></break>Doctors (D)<break></break>Powerful Others (O)</td><td rowspan="2">LOC-I</td><td>Intervention group</td><td>19.6 (5.5)</td><td>0.13 (−1.79 to 2.04)</td><td>0.91 (−1.92 to 3.75)</td><td rowspan="2">0.99</td><td rowspan="2">0.33</td><td rowspan="2">-</td><td rowspan="2">0.07</td><td rowspan="2">0.94</td><td rowspan="2">-</td></tr><tr><td>Wait-list control</td><td>16.5 (5.5)</td><td>1.5 (−0.50 to 3.50)</td><td>−0.78 (−3.19 to 1.62)</td></tr><tr><td rowspan="2">LOC-C</td><td>Intervention group</td><td>16.0 (7.2)</td><td>1.33 (−1.09 to 3.76)</td><td>1.14 (−1.83 to 4.10)</td><td rowspan="2">−1.69</td><td rowspan="2">0.10</td><td rowspan="2">-</td><td rowspan="2">0.73</td><td rowspan="2">0.47</td><td rowspan="2">-</td></tr><tr><td>Wait-list control</td><td>18.6 (6.4)</td><td>−1.09 (−2.88 to 0.70)</td><td>0.39 (−2.75 to 3.53)</td></tr><tr><td rowspan="2">LOC-D</td><td>Intervention group</td><td>12.7 (3.7)</td><td>0.63 (−0.88 to 2.13)</td><td>0.22 (−1.11 to 1.56)</td><td rowspan="2">−1.80</td><td rowspan="2">0.04 <sup>b,a</sup></td><td rowspan="2">0.28<sup>b</sup> (small)</td><td rowspan="2">0.39</td><td rowspan="2">0.70</td><td rowspan="2">-</td></tr><tr><td>Wait-list control</td><td>11.8 (3.3)</td><td>−0.91 (−1.98 to 0.16)</td><td>0.16 (−1.34 to 1.66)</td></tr><tr><td rowspan="2">LOC-O</td><td>Intervention group</td><td>8.0 (3.7)</td><td>0.13 (−1.38 to 1.63)</td><td>0.23 (−1.30 to 1.76)</td><td rowspan="2">0.064</td><td rowspan="2">0.95</td><td rowspan="2">-</td><td rowspan="2">0.40</td><td rowspan="2">0.69</td><td rowspan="2">-</td></tr><tr><td>Wait-list control</td><td>8.0 (3.0)</td><td>0.18 (−0.93 to 1.29)</td><td>0.17 (−1.21 to 1.54)</td></tr><tr><td rowspan="2" colspan="2">Exercise (hours)</td><td>Intervention group</td><td>1.4 (2.0)</td><td>0.38 (−0.22 to 0.97)</td><td>−0.28 (−1.14 to 0.58)</td><td rowspan="2">−1.03</td><td rowspan="2">0.31</td><td rowspan="2">-</td><td rowspan="2">0.6717</td><td rowspan="2">0.50</td><td rowspan="2">-</td></tr><tr><td>Wait-list control</td><td>1.7 (2.4)</td><td>−0.32 (−1.41 to 0.77)</td><td>0.86 (−0.54 to 2.25)</td></tr><tr><td rowspan="2" colspan="2">Nutrition (fruit serves/day)</td><td>Intervention group</td><td>2.2 (1.2)</td><td>0 (−.41 to 0.41)</td><td>0.32 (−0.05 to 0.69)</td><td rowspan="2">0.68</td><td rowspan="2">0.50</td><td rowspan="2">-</td><td rowspan="2">−1.80</td><td rowspan="2">0.04 <sup>b,a</sup></td><td rowspan="2">0.28 (small)</td></tr><tr><td>Wait-list control</td><td>2.4 (1.3)</td><td>0.21 (−0.24 to 0.66)</td><td>0.29 (−0.31 to 0.90)</td></tr></tbody></table><table-wrap-foot><p><sup>a</sup>significant finding. <sup>b</sup> one-sided finding. Effect size is the Cohen's d: small ≥ .20, medium ≥ .50, large ≥ .80</p></table-wrap-foot></table-wrap></p><p>Severity of PD as measured at baseline by the PDQ39 was consistent with H&Y stage 2 PD in both intervention and wait-list control groups. Mindfulness, as indicated by FMI scores, was consistent with the normal Australian population in both groups [<xref ref-type="bibr" rid="CR25">25</xref>] and, on average, the wait-list controls were more <italic>mindful</italic> than the intervention individuals as indicated by a small yet significantly better FMI average score at baseline (<italic>t</italic> = 2.31, <italic>p</italic> = 0.04). Depression and stress average scores at baseline were consistent with the Australian population [<xref ref-type="bibr" rid="CR31">31</xref>], but average anxiety scores were poorer than the Australian population and consistent with ‘mild’ degree anxiety. Overall, 16 % (9/56) of all participants had moderate or greater depression, 16 % (9/55) had moderate stress and 39 % (22/56) had moderate anxiety. The wait-list controls on average appeared to have poorer depression, stress and anxiety scores however differences were not significant. For the four dimensions of locus of control (Internal (I), Chance, Doctors, Powerful Others), both groups had similar average scores at baseline, except for one dimension, the internal (LOC-I) aspect for which there was a slight but significant difference between the two groups (<italic>t</italic> = −2.06, <italic>p</italic> = 0.04). Both groups reported similar average hours of exercise per week and average nutritional intake of fruit serves per day (Table <xref rid="Tab2" ref-type="table">2</xref>).</p><sec id="Sec19"><title>7-week impact of intervention, RCT analysis</title><p>The analysis at 7-weeks followed that of a standard two group RCT and change scores compared to baseline are shown in Table <xref rid="Tab2" ref-type="table">2</xref>. There was no difference in the primary outcome of PDQ39 since baseline, nor was there a difference between the intervention and wait-list control groups.</p><p>Mindfulness significantly improved in the intervention group after completing the intervention, showing a significant difference compared to the wait-list controls (<italic>t</italic> = −3.02, <italic>p</italic> < 0.01) and a medium effect size (Cohen's <italic>d</italic> = 0.61). Mental health, as measured by the DASS, suggested a small increase in depression in the intervention group since baseline, although this difference was not significantly different between groups (<italic>t</italic> = −0.66, <italic>p</italic> = 0.51). Anxiety scores on average did not change. However, stress significantly increased in the intervention group after completing the intervention, showing a significant increase compared to the wait-list controls (<italic>t</italic> = −2.61, 0.01) and a small effect size (Cohen's <italic>d</italic> = 0.32).</p><p>Locus of control measures showed a significant difference between groups in one dimension only, the internal aspect (LOC-I). This represented a significant increase in perceived internal control in the intervention group after completing the intervention compared to the wait-list controls (<italic>t</italic> = −1.8, <italic>p</italic> = 0.04) and a small effect size (Cohen's <italic>d</italic> = 0.28). Health behaviours as measured by average weekly exercise and daily fruit intake did not change.</p></sec><sec id="Sec20"><title>6-month impact of intervention, pre- post analysis</title><p>The 6-month analysis differed from the 7-weeks analysis because all participants had received the intervention approximately 6 months prior; therefore this analysis was a before and after examination of scores using paired t-tests and all participants. Comparing the primary outcome, PDQ39, there was no measurable difference at 6 months compared to baseline scores. Of the eight dimensions of the PDQ39, only one suggested a possible improvement since baseline had occurred on average, and this was the activities in daily life (PDQ39-ADL) sub-category (<italic>t</italic> = −1.8, <italic>p</italic> = 0.04) and a small effect size (Cohen's <italic>d</italic> = 0.28).</p><p>Increased mindfulness on average was measured at 6 months, and this results was significant (<italic>t</italic> = 2.35, <italic>p</italic> = 0.02) with a small effect size (Cohen's <italic>d</italic> = 0.32).</p><p>Decreased stress on average was measured at 6 months, and this results was significant (<italic>t</italic> = −1.8, <italic>p</italic> = 0.04) with a small effect size (Cohen's <italic>d</italic> = 0.28).</p><p>Health behaviours as measured by average daily fruit intake improved, and this improvement was significant (<italic>t</italic> = −1.8, <italic>p</italic> = 0.04) with a small effect size (Cohen's <italic>d</italic> = 0.28). The average increase in fruit intake corresponded to an extra 1/3 serves extra per day or approximately 2 serves extra per week.</p></sec><sec id="Sec21"><title>Adherence analysis</title><p>Adherence data was plotted against the study measures. There were no significant correlations between adherence and any outcome measures during the program or in the week after the 6-week program. The 6 month difference scores showed no significant correlations with adherence except for the depression (DASS-d) measure, see Fig. <xref rid="Fig3" ref-type="fig">3</xref>. The correlation with increased depression and adherence was weak yet significant (Pearson’s <italic>r</italic> = 0.3, <italic>p</italic> = 0.02) at 6 months.<fig id="Fig3"><label>Fig. 3</label><caption><p>Adherence to the program (<italic>x-axis</italic>) and depression scores (<italic>y-axis</italic>) at 6 months after program completion. High adherence scores represent more practice of the program principles. Positive depression change scores represent greater depression at 6 months compared to baseline. The correlation between increased depression and adherence was weak, yet significant (Pearson’s <italic>r</italic> = 0.3, <italic>p</italic> = 0.02</p></caption><graphic xlink:href="12883_2016_685_Fig3_HTML" id="MO3"></graphic></fig></p></sec></sec><sec id="Sec22"><title>Discussion</title><p>Involvement in a mindfulness-based lifestyle program for community living adults with H&Y [<xref ref-type="bibr" rid="CR19">19</xref>] stage 2 PD resulted in a significant increase in mindfulness<italic>,</italic> stress-management and improvement in activities of daily living at 6 month follow up. This positive effect on participant motor function is not uncommon where behaviour-change is the central focus of the intervention [<xref ref-type="bibr" rid="CR32">32</xref>]. A similar study exploring the effects of the provision of behavioural advice on PD symptom management found improved motor performance and reduced tremor amongst PD participants when compared to a control group [<xref ref-type="bibr" rid="CR33">33</xref>]. Furthermore, improvements in function may be found where advice on behaviour-change is delivered within a supportive group setting [<xref ref-type="bibr" rid="CR33">33</xref>, <xref ref-type="bibr" rid="CR34">34</xref>]. The embedded qualitative study highlighted the group support that was part of the program had assisted participants in coping with PD, particularly when groups shared chronic disease management ‘tips’ and experiences [<xref ref-type="bibr" rid="CR35">35</xref>, <xref ref-type="bibr" rid="CR36">36</xref>]. The positive group dynamic of the mindfulness-based lifestyle program delivered in our study offered opportunities for participants to share ideas for better disease management and may be reflected in the significant increase in participants’ ADL after 6-months from receiving the program. This sustained effect was similarly noted in participant improvement in emotional well-being. Positive outcomes for motor and non-motor dysfunction are particularly reflected where mindfulness is strongly embedded [<xref ref-type="bibr" rid="CR37">37</xref>] and emphasised in intervention programs. Others have found that interventions which promote personal control may assist in reducing disability and improving quality of life in people with PD [<xref ref-type="bibr" rid="CR38">38</xref>].</p><p>Emerging evidence which suggests that mindfulness may lead to neuroplastic changes of regions in the brain involved in the regulation of emotion [<xref ref-type="bibr" rid="CR39">39</xref>, <xref ref-type="bibr" rid="CR40">40</xref>] and improvements in emotional well-being, particularly stress-management, anxiety and depression [<xref ref-type="bibr" rid="CR36">36</xref>, <xref ref-type="bibr" rid="CR41">41</xref>, <xref ref-type="bibr" rid="CR42">42</xref>] for people with chronic and neurological disease. Our study however showed a statistically but not clinically significant increase in depression following the intervention which returned to normal at 6 months. In the initial stages of learning mindfulness people can report more awareness of depressive symptoms that were already present [<xref ref-type="bibr" rid="CR43">43</xref>]. This may be further compounded by negative effects in changing PD medication dosage [<xref ref-type="bibr" rid="CR44">44</xref>] and the challenges associated with adapting to chronic disease, whereby making adjustments to a person’s social and work life can be stressful or create worry until the benefits of those changes start to make themselves obvious. It should be noted that severity of PD symptoms is evidenced to fluctuate throughout the year [<xref ref-type="bibr" rid="CR45">45</xref>] with poorer outcomes reported during busy social periods, such as Christmas, which is when our study took place. There also appeared to be a correlation between increased adherence to the program and depression at 6 months, which may need to be considered as a possible unwanted outcome in a bigger study.</p><p>We also found an increase in stress immediately after the 6-week program and then significant reduction compared to baseline in stress at 6 months post program, primarily associated with a recent PD diagnosis. Importantly these benefits appeared to be sustainable over longer periods of time signifying indicating the potential to improve mental well-being in those recently diagnosed with PD. Early treatment strategies which aid in the diminishment of symptom severity, or the stress associated in experiencing symptoms, are seen to have more meaningful impacts in improving quality of life [<xref ref-type="bibr" rid="CR46">46</xref>].</p><sec id="Sec23"><title>Mindfulness: a feasible therapeutic intervention</title><p>We found that mindfulness training may be a feasible therapeutic intervention within a population of persons with PD. Previous evidence has suggested greater benefits from mindfulness training particularly for depression but only after sustained or formal practice [<xref ref-type="bibr" rid="CR47">47</xref>]. Our findings indicate that by simply introducing mindfulness practices, benefits for people with PD can be achieved. After participating in only six sessions of a holistic lifestyle program which included up to 20 min of mindfulness training each week increases in participant mindfulness levels were found, and, importantly, appeared to be retained longitudinally. Despite many not engaging in continued formal practice, positive psychological benefits of the practice are still found [<xref ref-type="bibr" rid="CR48">48</xref>]. For participants in this study, knowledge of mindfulness techniques assisted with better management of anxiety and stress.</p><p>Although ad hoc utilisation of mindfulness techniques (as opposed to formal practice) appeared to bring benefit to the study population, it was evident that where mindfulness was practiced more regularly and formally participants were more likely to report positive improvements to their well-being. This finding is consistent with the literature. As mindfulness skills become more integrated into a regular routine, the greater the benefit in stress reduction and symptom management [<xref ref-type="bibr" rid="CR49">49</xref>, <xref ref-type="bibr" rid="CR50">50</xref>].</p><sec id="Sec24"><title>Limitations</title><p>An important limitation was the relatively small sample size of our exploratory study. A larger sample is now needed to confidently determine significant changes in patient outcomes. The programme was facilitated by the author of the model (CH) which may have introduced some bias. Furthermore, our inclusion criteria and choice of program location may have limited our study sample to only include participants of a higher socio-demographic status and lower disease severity than the general PD population and may, therefore, reduce the generalisability of our study findings. This effect is not uncommon in community based studies recruiting voluntary participants [<xref ref-type="bibr" rid="CR51">51</xref>]. Finally, our primary outcome measure (PDQ-39) and use of the DASS-21 anxiety sub-scale may also raise some limitations. Due to the ambiguity of scoring the PDQ-39 [<xref ref-type="bibr" rid="CR52">52</xref>, <xref ref-type="bibr" rid="CR53">53</xref>], and poor loading and internal consistency of the DASS-21 anxiety sub-scale, interpreting valid change magnitudes amongst a sample with early stage PD disease severity is challenging and may not reflect the true changes of disease progression from the patient perspective [<xref ref-type="bibr" rid="CR54">54</xref>]. Larger studies should be aware of these limitation when including the PDQ-31 and DASS-21 as outcome measures.</p></sec></sec></sec><sec id="Sec25"><title>Conclusions</title><p>This small, community based prospective mixed-method randomised clinical trial incorporating a before and after design with a waitlist control provides needed evidence about the value of incorporating mindfulness training into the treatment options available to people with PD. Our findings suggest that mindfulness-based lifestyle programs may have great potential to assist participants in managing ongoing difficulties associated with a neurological condition such as Parkinson’s disease. In particular, our study provides suggestive evidence of potential long term benefits for the management of PD after receiving a mindfulness-based lifestyle program, when delivered alongside conventional treatment during early stages of diagnosis. A more definitive study should be conducted in a larger sample of PD patients to further explore the suggested significant increases in activities of daily living and mindfulness in reducing outcomes of stress and anxiety in PD patients.</p></sec></body><back><glossary><title>Abbreviations</title><def-list><def-item><term>ADL</term><def><p>Activities of daily living</p></def></def-item><def-item><term>BOD</term><def><p>Bodily discomfort</p></def></def-item><def-item><term>COG</term><def><p>Cognitions</p></def></def-item><def-item><term>COM</term><def><p>Communication</p></def></def-item><def-item><term>DASS</term><def><p>Depression anxiety and stress scales</p></def></def-item><def-item><term>EMO</term><def><p>Emotional well-being</p></def></def-item><def-item><term>FMI</term><def><p>Freiberg mindfulness index</p></def></def-item><def-item><term>H&Y</term><def><p>Hoehn & Yahr</p></def></def-item><def-item><term>HBQ</term><def><p>Health behaviours questionnaire</p></def></def-item><def-item><term>HrQOL</term><def><p>Health related quality of life</p></def></def-item><def-item><term>LOC</term><def><p>Locus of control</p></def></def-item><def-item><term>MDB</term><def><p>Mobility</p></def></def-item><def-item><term>PD</term><def><p>Parkinson’s disease</p></def></def-item><def-item><term>PDQ</term><def><p>Parkinson’s disease questionnaire</p></def></def-item><def-item><term>PV</term><def><p>Parkinson’s victoria</p></def></def-item><def-item><term>SOC</term><def><p>Social support</p></def></def-item><def-item><term>STI</term><def><p>Stigma</p></def></def-item></def-list></glossary><ack><title>Acknowledgements</title><p>The authors gratefully acknowledge our funder Parkinson’s Victoria and all those who participated in the ESSENCE Mindfulness Lifestyle Research Program. We also gratefully acknowledge the input of all the member of the Advisory Board, including Dr Prue Morgan, Sharon Daborn, Dr Louise Cooper, Sarah McGregor and others. We also would like to acknowledge the assistance of Parkinson’s Victoria staff.</p><sec id="FPar1"><title>Funding</title><p>Funded by Parkinson’s Victoria.</p></sec><sec id="FPar2"><title>Availability of data and material</title><p>The datasets generated and analysed during the current study are not publicly available nor able to be shared due reasons of upholding patient privacy and confidentiality.</p></sec><sec id="FPar3"><title>Author’s contributions</title><p>JA conceived of the study, participated in its design, data collection, analysis, interpretation of data and drafting and revising the manuscript. JE participated in the design of the study, analysis and interpretation of data, involved in drafting and revising the manuscript. BV participated in the delivery of the study, data collection, analysis and interpretation of the data, drafting and revising of the manuscript. CH conceived of the study, participated in its design and delivery of the study, interpretation of data and involved in the revision of the manuscript. JH participated in the design of the study, analysis and interpretation of data, involved in drafting the manuscript. GR led the design of the study, interpretation of data, involved in drafting and revising the manuscript. All authors have read and approved the final manuscript.</p></sec><sec id="FPar4"><title>Competing interests</title><p>CH is the author of the program that was delivered in the trial. The authors declare that they have no other competing interests.</p></sec><sec id="FPar5"><title>Consent for publication</title><p>Not applicable.</p></sec><sec id="FPar6"><title>Ethics approval and consent to participate</title><p>All participants provided informed consent prior to their involvement in the study. The study was approved the Monash University Human Research Ethics Committee project number CF11/2662-2011001553.</p></sec></ack><ref-list id="Bib1"><title>References</title><ref id="CR1"><label>1.</label><element-citation publication-type="journal"><person-group person-group-type="author"><name><surname>Kalia</surname><given-names>LV</given-names></name><name><surname>Lang</surname><given-names>AE</given-names></name></person-group><article-title>Parkinson's disease</article-title><source>Lancet</source><year>2015</year><volume>386</volume><issue>9996</issue><fpage>896</fpage><lpage>912</lpage><pub-id pub-id-type="doi">10.1016/S0140-6736(14)61393-3</pub-id><pub-id pub-id-type="pmid">25904081</pub-id></element-citation></ref><ref id="CR2"><label>2.</label><element-citation publication-type="book"><person-group person-group-type="author"><collab>World Health Organization</collab></person-group><article-title>Neurological disorders: a public health approach (Dementia, Epilepsy, Headache disorders, Multiple sclerosis, Neuroinfections)</article-title><source>World Health Organization. Neurological disorders: public health challenges</source><year>2006</year><publisher-loc>Geneva</publisher-loc><publisher-name>WHO Press</publisher-name><fpage>41</fpage><lpage>110</lpage></element-citation></ref><ref id="CR3"><label>3.</label><mixed-citation publication-type="other">Parkinson's Australia. Living with Parkinson's disease. An updated economic analysis 2014. Delloite Access Economics Pty Ltd. 2015. <ext-link ext-link-type="uri" xlink:href="http://www.parkinsons.org.au/Documents/Living%20with%20Parkinsons%2027082015%20FINAL.pdf">http://www.parkinsons.org.au/Documents/Living%20with%20Parkinsons%2027082015%20FINAL.pdf</ext-link>. Accessed 23 May 2016.</mixed-citation></ref><ref id="CR4"><label>4.</label><element-citation publication-type="journal"><person-group person-group-type="author"><name><surname>Pringsheim</surname><given-names>T</given-names></name><name><surname>Jette</surname><given-names>N</given-names></name><name><surname>Frolkis</surname><given-names>A</given-names></name><name><surname>Steeves</surname><given-names>TDL</given-names></name></person-group><article-title>The prevalence of Parkinson's disease: a systematic review and meta-analysis</article-title><source>Mov Disord</source><year>2014</year><volume>29</volume><issue>13</issue><fpage>1583</fpage><lpage>90</lpage><pub-id pub-id-type="doi">10.1002/mds.25945</pub-id><pub-id pub-id-type="pmid">24976103</pub-id></element-citation></ref><ref id="CR5"><label>5.</label><element-citation publication-type="journal"><person-group person-group-type="author"><name><surname>Van Den Eeden</surname><given-names>SK</given-names></name><name><surname>Tanner</surname><given-names>CM</given-names></name><name><surname>Bernstein</surname><given-names>AL</given-names></name><name><surname>Fross</surname><given-names>RD</given-names></name><name><surname>Leimpeter</surname><given-names>A</given-names></name><name><surname>Bloch</surname><given-names>DA</given-names></name><etal></etal></person-group><article-title>Incidence of Parkinson’s disease: variation by age, gender, and race/ethnicity</article-title><source>Am J Epidemiol</source><year>2003</year><volume>157</volume><issue>11</issue><fpage>1015</fpage><lpage>22</lpage><pub-id pub-id-type="doi">10.1093/aje/kwg068</pub-id><pub-id pub-id-type="pmid">12777365</pub-id></element-citation></ref><ref id="CR6"><label>6.</label><element-citation publication-type="journal"><person-group person-group-type="author"><name><surname>Barone</surname><given-names>P</given-names></name><name><surname>Antonini</surname><given-names>A</given-names></name><name><surname>Colosimo</surname><given-names>C</given-names></name><name><surname>Marconi</surname><given-names>R</given-names></name><name><surname>Morgante</surname><given-names>L</given-names></name><name><surname>Avarello</surname><given-names>TP</given-names></name><etal></etal></person-group><article-title>The PRIAMO study: a multicenter assessment of nonmotor symptoms and their impact on quality of life in Parkinson's disease</article-title><source>Mov Disord</source><year>2009</year><volume>24</volume><issue>11</issue><fpage>1641</fpage><lpage>9</lpage><pub-id pub-id-type="doi">10.1002/mds.22643</pub-id><pub-id pub-id-type="pmid">19514014</pub-id></element-citation></ref><ref id="CR7"><label>7.</label><element-citation publication-type="journal"><person-group person-group-type="author"><name><surname>Schrag</surname><given-names>A</given-names></name><name><surname>Hovris</surname><given-names>A</given-names></name><name><surname>Morley</surname><given-names>D</given-names></name><name><surname>Quinn</surname><given-names>N</given-names></name><name><surname>Jahanshahi</surname><given-names>M</given-names></name></person-group><article-title>Caregiver-burden in Parkinson's disease is closely associated with psychiatric symptoms, falls, and disability</article-title><source>Parkinsonism Relat Disord</source><year>2006</year><volume>12</volume><issue>1</issue><fpage>35</fpage><lpage>41</lpage><pub-id pub-id-type="doi">10.1016/j.parkreldis.2005.06.011</pub-id><pub-id pub-id-type="pmid">16271496</pub-id></element-citation></ref><ref id="CR8"><label>8.</label><element-citation publication-type="journal"><person-group person-group-type="author"><name><surname>Ott</surname><given-names>MJ</given-names></name><name><surname>Norris</surname><given-names>RL</given-names></name><name><surname>Bauer-Wu</surname><given-names>SM</given-names></name></person-group><article-title>Mindfulness meditation for oncology patients: a discussion and critical review</article-title><source>Integr Cancer Ther</source><year>2006</year><volume>5</volume><issue>2</issue><fpage>98</fpage><lpage>108</lpage><pub-id pub-id-type="doi">10.1177/1534735406288083</pub-id><pub-id pub-id-type="pmid">16685074</pub-id></element-citation></ref><ref id="CR9"><label>9.</label><element-citation publication-type="journal"><person-group person-group-type="author"><name><surname>Grossman</surname><given-names>P</given-names></name><name><surname>Tiefenthaler-Gilmer</surname><given-names>U</given-names></name><name><surname>Raysz</surname><given-names>A</given-names></name><name><surname>Kesper</surname><given-names>U</given-names></name></person-group><article-title>Mindfulness training as an intervention for fibromyalgia: evidence of postintervention and 3-year follow-up benefits in well-being</article-title><source>Psychother Psychosom</source><year>2007</year><volume>76</volume><issue>4</issue><fpage>226</fpage><lpage>33</lpage><pub-id pub-id-type="doi">10.1159/000101501</pub-id><pub-id pub-id-type="pmid">17570961</pub-id></element-citation></ref><ref id="CR10"><label>10.</label><element-citation publication-type="journal"><person-group person-group-type="author"><name><surname>Pradhan</surname><given-names>EK</given-names></name><name><surname>Baumgarten</surname><given-names>M</given-names></name><name><surname>Langenberg</surname><given-names>P</given-names></name><name><surname>Handwerger</surname><given-names>B</given-names></name><name><surname>Gilpin</surname><given-names>AK</given-names></name><name><surname>Magyari</surname><given-names>T</given-names></name><etal></etal></person-group><article-title>Effect of mindfulness-based stress reduction in rheumatoid arthritis patients</article-title><source>Arthritis Rheum</source><year>2007</year><volume>57</volume><issue>7</issue><fpage>1134</fpage><lpage>42</lpage><pub-id pub-id-type="doi">10.1002/art.23010</pub-id><pub-id pub-id-type="pmid">17907231</pub-id></element-citation></ref><ref id="CR11"><label>11.</label><element-citation publication-type="journal"><person-group person-group-type="author"><name><surname>Morone</surname><given-names>NE</given-names></name><name><surname>Greco</surname><given-names>CM</given-names></name><name><surname>Weiner</surname><given-names>DK</given-names></name></person-group><article-title>Mindfulness meditation for the treatment of chronic low back pain in older adults: a randomized controlled pilot study</article-title><source>Pain</source><year>2008</year><volume>134</volume><issue>3</issue><fpage>310</fpage><lpage>9</lpage><pub-id pub-id-type="doi">10.1016/j.pain.2007.04.038</pub-id><pub-id pub-id-type="pmid">17544212</pub-id></element-citation></ref><ref id="CR12"><label>12.</label><element-citation publication-type="journal"><person-group person-group-type="author"><name><surname>Bohlmeijer</surname><given-names>E</given-names></name><name><surname>Prenger</surname><given-names>R</given-names></name><name><surname>Taal</surname><given-names>E</given-names></name><name><surname>Cuijpers</surname><given-names>P</given-names></name></person-group><article-title>The effects of mindfulness-based stress reduction therapy on mental health of adults with a chronic medical disease: a meta-analysis</article-title><source>J Psychosom Res</source><year>2010</year><volume>68</volume><issue>6</issue><fpage>539</fpage><lpage>44</lpage><pub-id pub-id-type="doi">10.1016/j.jpsychores.2009.10.005</pub-id><pub-id pub-id-type="pmid">20488270</pub-id></element-citation></ref><ref id="CR13"><label>13.</label><element-citation publication-type="journal"><person-group person-group-type="author"><name><surname>Grossman</surname><given-names>P</given-names></name><name><surname>Kappos</surname><given-names>L</given-names></name><name><surname>Gensicke</surname><given-names>H</given-names></name><name><surname>D'Souza</surname><given-names>M</given-names></name><name><surname>Mohr</surname><given-names>DC</given-names></name><name><surname>Penner</surname><given-names>IK</given-names></name><etal></etal></person-group><article-title>MS quality of life, depression, and fatigue improve after mindfulness training: a randomized trial</article-title><source>Neurology</source><year>2010</year><volume>75</volume><issue>13</issue><fpage>1141</fpage><lpage>9</lpage><pub-id pub-id-type="doi">10.1212/WNL.0b013e3181f4d80d</pub-id><pub-id pub-id-type="pmid">20876468</pub-id></element-citation></ref><ref id="CR14"><label>14.</label><element-citation publication-type="journal"><person-group person-group-type="author"><name><surname>Jelinek</surname><given-names>G</given-names></name><name><surname>Hassed</surname><given-names>C</given-names></name></person-group><article-title>Managing multiple sclerosis in primary care: are we forgetting something?</article-title><source>Qual Prim Care</source><year>2009</year><volume>17</volume><issue>1</issue><fpage>55</fpage><lpage>61</lpage><pub-id pub-id-type="pmid">19281675</pub-id></element-citation></ref><ref id="CR15"><label>15.</label><element-citation publication-type="journal"><person-group person-group-type="author"><name><surname>Kabat-Zinn</surname><given-names>J</given-names></name><name><surname>Wheeler</surname><given-names>E</given-names></name><name><surname>Light</surname><given-names>T</given-names></name><name><surname>Skillings</surname><given-names>A</given-names></name><name><surname>Scharf</surname><given-names>MJ</given-names></name><name><surname>Cropley</surname><given-names>TG</given-names></name><etal></etal></person-group><article-title>Influence of a mindfulness meditation-based stress reduction intervention on rates of skin clearing in patients with moderate to severe psoriasis undergoing phototherapy (UVB) and photochemotherapy (PUVA)</article-title><source>Psychosom Med</source><year>1998</year><volume>60</volume><issue>5</issue><fpage>625</fpage><lpage>32</lpage><pub-id pub-id-type="doi">10.1097/00006842-199809000-00020</pub-id><pub-id pub-id-type="pmid">9773769</pub-id></element-citation></ref><ref id="CR16"><label>16.</label><element-citation publication-type="journal"><person-group person-group-type="author"><name><surname>Hadgkiss</surname><given-names>EJ</given-names></name><name><surname>Jelinek</surname><given-names>GA</given-names></name><name><surname>Weiland</surname><given-names>TJ</given-names></name><name><surname>Rumbold</surname><given-names>G</given-names></name><name><surname>Mackinlay</surname><given-names>CA</given-names></name><name><surname>Gutbrod</surname><given-names>S</given-names></name><etal></etal></person-group><article-title>Health-related quality of life outcomes at 1 and 5 years after a residential retreat promoting lifestyle modification for people with multiple sclerosis</article-title><source>J Neurol Sci</source><year>2013</year><volume>34</volume><issue>2</issue><fpage>187</fpage><lpage>95</lpage><pub-id pub-id-type="doi">10.1007/s10072-012-0982-4</pub-id></element-citation></ref><ref id="CR17"><label>17.</label><element-citation publication-type="journal"><person-group person-group-type="author"><name><surname>Pickut</surname><given-names>BA</given-names></name><name><surname>Vanneste</surname><given-names>S</given-names></name><name><surname>Hirsch</surname><given-names>MA</given-names></name><name><surname>Van Heck</surname><given-names>W</given-names></name><name><surname>Kerckhofs</surname><given-names>E</given-names></name><name><surname>Marien</surname><given-names>P</given-names></name><etal></etal></person-group><article-title>Mindfulness training among individuals with Parkinson's disease: neurobehavioral effects</article-title><source>J Parkinsons Dis</source><year>2015</year><volume>2015</volume><fpage>1</fpage><lpage>6</lpage><pub-id pub-id-type="doi">10.1155/2015/816404</pub-id></element-citation></ref><ref id="CR18"><label>18.</label><element-citation publication-type="journal"><person-group person-group-type="author"><name><surname>Fitzpatrick</surname><given-names>L</given-names></name><name><surname>Simpson</surname><given-names>J</given-names></name><name><surname>Smith</surname><given-names>A</given-names></name></person-group><article-title>A qualitative analysis of mindfulness-based cognitive therapy (MBCT) in Parkinson's disease</article-title><source>Psychol Psychother-T</source><year>2010</year><volume>83</volume><fpage>179</fpage><lpage>92</lpage><pub-id pub-id-type="doi">10.1348/147608309X471514</pub-id></element-citation></ref><ref id="CR19"><label>19.</label><element-citation publication-type="journal"><person-group person-group-type="author"><name><surname>Hoehn</surname><given-names>M</given-names></name><name><surname>Yahr</surname><given-names>M</given-names></name></person-group><article-title>Parkinsonism: onset, progression, and mortality</article-title><source>Neurology</source><year>1967</year><volume>17</volume><fpage>427</fpage><pub-id pub-id-type="doi">10.1212/WNL.17.5.427</pub-id><pub-id pub-id-type="pmid">6067254</pub-id></element-citation></ref><ref id="CR20"><label>20.</label><element-citation publication-type="journal"><person-group person-group-type="author"><name><surname>Advocat</surname><given-names>J</given-names></name><name><surname>Russell</surname><given-names>G</given-names></name><name><surname>Enticott</surname><given-names>J</given-names></name><name><surname>Hassed</surname><given-names>C</given-names></name><name><surname>Hester</surname><given-names>J</given-names></name><name><surname>Vandenberg</surname><given-names>B</given-names></name></person-group><article-title>The effects of a mindfulness-based lifestyle programme for adults with Parkinson’s disease: protocol for a mixed methods, randomised two-group control study</article-title><source>BMJ Open</source><year>2013</year><volume>3</volume><issue>10</issue><pub-id pub-id-type="doi">10.1136/bmjopen-2013-003326</pub-id><pub-id pub-id-type="pmid">24114370</pub-id></element-citation></ref><ref id="CR21"><label>21.</label><mixed-citation publication-type="other">Better Health Channel. Parkinson's disease. Department of Health and Human Services. 2016. <ext-link ext-link-type="uri" xlink:href="https://www.betterhealth.vic.gov.au/health/conditionsandtreatments/parkinsons-disease">https://www.betterhealth.vic.gov.au/health/conditionsandtreatments/parkinsons-disease</ext-link>. Accessed 23 May 2016.</mixed-citation></ref><ref id="CR22"><label>22.</label><mixed-citation publication-type="other">The Michael J Fox Foundation. Clinical trials recruitment best practices manual. Michael J Fox Foundation for Parkinson’s Research. 2011. <ext-link ext-link-type="uri" xlink:href="https://www.michaeljfox.org/files/MJFF_Recruitment_Best_Practices_manual.pdf">https://www.michaeljfox.org/files/MJFF_Recruitment_Best_Practices_manual.pdf</ext-link>. Accessed 20 Oct 2012.</mixed-citation></ref><ref id="CR23"><label>23.</label><mixed-citation publication-type="other">The Michael J Fox Foundation. Fox trial Finder. Michael J Fox Foundation for Parkinson’s Research. 2016. <ext-link ext-link-type="uri" xlink:href="https://foxtrialfinder.michaeljfox.org/">https://foxtrialfinder.michaeljfox.org/</ext-link>. Accessed 20 Oct 2012.</mixed-citation></ref><ref id="CR24"><label>24.</label><element-citation publication-type="journal"><person-group person-group-type="author"><name><surname>Jenkinson</surname><given-names>C</given-names></name><name><surname>Fitzpatrick</surname><given-names>R</given-names></name><name><surname>Peto</surname><given-names>V</given-names></name><name><surname>Greenhall</surname><given-names>R</given-names></name><name><surname>Hyman</surname><given-names>N</given-names></name></person-group><article-title>The Parkinson’s Disease Questionnaire (PDQ-39): development and validation of a Parkinson’s disease summary index score</article-title><source>Age Ageing</source><year>1997</year><volume>26</volume><fpage>353</fpage><lpage>7</lpage><pub-id pub-id-type="doi">10.1093/ageing/26.5.353</pub-id><pub-id pub-id-type="pmid">9351479</pub-id></element-citation></ref><ref id="CR25"><label>25.</label><element-citation publication-type="journal"><person-group person-group-type="author"><name><surname>Walach</surname><given-names>H</given-names></name><name><surname>Buchheld</surname><given-names>N</given-names></name><name><surname>Buttenmüller</surname><given-names>V</given-names></name><name><surname>Kleinknecht</surname><given-names>N</given-names></name><name><surname>Schmidt</surname><given-names>S</given-names></name></person-group><article-title>Measuring mindfulness-the Freiburg Mindfulness Inventory (FMI)</article-title><source>Pers Indivd Dif</source><year>2006</year><volume>40</volume><fpage>1543</fpage><lpage>55</lpage><pub-id pub-id-type="doi">10.1016/j.paid.2005.11.025</pub-id></element-citation></ref><ref id="CR26"><label>26.</label><element-citation publication-type="book"><person-group person-group-type="author"><name><surname>Lovibond</surname><given-names>S</given-names></name><name><surname>Lovibond</surname><given-names>P</given-names></name></person-group><source>Manual for the depression anxiety stress scales</source><year>1995</year><edition>2</edition><publisher-loc>Sydney</publisher-loc><publisher-name>Psychology Foundation</publisher-name></element-citation></ref><ref id="CR27"><label>27.</label><element-citation publication-type="journal"><person-group person-group-type="author"><name><surname>Wallston</surname><given-names>KA</given-names></name></person-group><article-title>The validity of the multidimensional health locus of control scales</article-title><source>J Health Psychol</source><year>2005</year><volume>10</volume><issue>5</issue><fpage>623</fpage><lpage>31</lpage><pub-id pub-id-type="doi">10.1177/1359105305055304</pub-id><pub-id pub-id-type="pmid">16033784</pub-id></element-citation></ref><ref id="CR28"><label>28.</label><mixed-citation publication-type="other">Australian Bureau of Statistics. National health survey: users’ guide - electronic publication, 2007–08. Australian Bureau of Statistics. 2009. <ext-link ext-link-type="uri" xlink:href="http://www.abs.gov.au/AUSSTATS/abs@.nsf/allprimarymainfeatures/2851D0FD9C52AB56CA257ACC000E3DE1">http://www.abs.gov.au/AUSSTATS/abs@.nsf/allprimarymainfeatures/2851D0FD9C52AB56CA257ACC000E3DE1</ext-link>. Accessed 23 May 2016.</mixed-citation></ref><ref id="CR29"><label>29.</label><mixed-citation publication-type="other">Hays RD. The Medical Outcomes Study (MOS) measures of patient adherence. Rand Health. 1994. <ext-link ext-link-type="uri" xlink:href="http://www.texasrhp12.com/downloads/MOS_adherence_survey.pdf">http://www.texasrhp12.com/downloads/MOS_adherence_survey.pdf</ext-link>. Accessed 20 Oct 2012.</mixed-citation></ref><ref id="CR30"><label>30.</label><element-citation publication-type="book"><person-group person-group-type="author"><name><surname>Cohen</surname><given-names>J</given-names></name></person-group><source>Statistical power analysis for the behavioral sciences</source><year>1988</year><edition>2</edition><publisher-loc>Hillsdale</publisher-loc><publisher-name>Lawrence Earlbaum Associates</publisher-name></element-citation></ref><ref id="CR31"><label>31.</label><element-citation publication-type="journal"><person-group person-group-type="author"><name><surname>Lovibond</surname><given-names>PF</given-names></name><name><surname>Lovibond</surname><given-names>SH</given-names></name></person-group><article-title>The structure of negative emotional states: comparison of the Depression Anxiety Stress Scales (DASS) with the Beck Depression and Anxiety Inventories</article-title><source>Behav Res Ther</source><year>1995</year><volume>33</volume><issue>3</issue><fpage>335</fpage><lpage>43</lpage><pub-id pub-id-type="doi">10.1016/0005-7967(94)00075-U</pub-id><pub-id pub-id-type="pmid">7726811</pub-id></element-citation></ref><ref id="CR32"><label>32.</label><element-citation publication-type="journal"><person-group person-group-type="author"><name><surname>Mohr</surname><given-names>B</given-names></name><name><surname>Müller</surname><given-names>V</given-names></name><name><surname>Mattes</surname><given-names>R</given-names></name><name><surname>Rosin</surname><given-names>R</given-names></name><name><surname>Federmann</surname><given-names>B</given-names></name><name><surname>Strehl</surname><given-names>U</given-names></name><etal></etal></person-group><article-title>Behavioral treatment of Parkinson's disease leads to improvement of motor skills and to tremor reduction</article-title><source>Behav Ther</source><year>1996</year><volume>27</volume><issue>2</issue><fpage>235</fpage><lpage>55</lpage><pub-id pub-id-type="doi">10.1016/S0005-7894(96)80016-5</pub-id></element-citation></ref><ref id="CR33"><label>33.</label><element-citation publication-type="journal"><person-group person-group-type="author"><name><surname>Payne</surname><given-names>JA</given-names></name></person-group><article-title>Group learning for adults with disabilities or chronic disease</article-title><source>Rehabil Nurs</source><year>1995</year><volume>20</volume><issue>5</issue><fpage>268</fpage><lpage>72</lpage><pub-id pub-id-type="doi">10.1002/j.2048-7940.1995.tb01643.x</pub-id><pub-id pub-id-type="pmid">7569305</pub-id></element-citation></ref><ref id="CR34"><label>34.</label><element-citation publication-type="journal"><person-group person-group-type="author"><name><surname>Schreurs</surname><given-names>KMG</given-names></name><name><surname>De Ridder</surname><given-names>DTD</given-names></name><name><surname>Bensing</surname><given-names>JM</given-names></name></person-group><article-title>A one year study of coping, social support and quality of life in parkinson's disease</article-title><source>Psychol Health</source><year>2000</year><volume>15</volume><issue>1</issue><fpage>109</fpage><lpage>21</lpage><pub-id pub-id-type="doi">10.1080/08870440008400292</pub-id></element-citation></ref><ref id="CR35"><label>35.</label><element-citation publication-type="journal"><person-group person-group-type="author"><name><surname>Olanow</surname><given-names>CW</given-names></name><name><surname>Watts</surname><given-names>RL</given-names></name><name><surname>Koller</surname><given-names>WC</given-names></name></person-group><article-title>An algorithm (decision tree) for the management of Parkinson’s disease (2001): treatment guidelines</article-title><source>Neurology</source><year>2001</year><volume>56</volume><issue>suppl 5</issue><fpage>S1</fpage><lpage>88</lpage><pub-id pub-id-type="doi">10.1212/WNL.56.suppl_5.S1</pub-id><pub-id pub-id-type="pmid">11402154</pub-id></element-citation></ref><ref id="CR36"><label>36.</label><element-citation publication-type="journal"><person-group person-group-type="author"><name><surname>Cairns</surname><given-names>V</given-names></name><name><surname>Murray</surname><given-names>C</given-names></name></person-group><article-title>How do the features of mindfulness-based cognitive therapy contribute to positive therapeutic change? A Meta-synthesis of qualitative studies</article-title><source>Behav Cogn Psychoth</source><year>2015</year><volume>43</volume><issue>03</issue><fpage>342</fpage><lpage>59</lpage><pub-id pub-id-type="doi">10.1017/S1352465813000945</pub-id></element-citation></ref><ref id="CR37"><label>37.</label><element-citation publication-type="journal"><person-group person-group-type="author"><name><surname>Bega</surname><given-names>D</given-names></name><name><surname>Zadikoff</surname><given-names>C</given-names></name></person-group><article-title>Complementary & alternative management of Parkinson’s disease: an evidence-based review of eastern influenced practices</article-title><source>J Mov Disord</source><year>2014</year><volume>7</volume><issue>2</issue><fpage>57</fpage><lpage>66</lpage><pub-id pub-id-type="doi">10.14802/jmd.14009</pub-id><pub-id pub-id-type="pmid">25360229</pub-id></element-citation></ref><ref id="CR38"><label>38.</label><element-citation publication-type="journal"><person-group person-group-type="author"><name><surname>Gruber-Baldini</surname><given-names>AL</given-names></name><name><surname>Ye</surname><given-names>J</given-names></name><name><surname>Anderson</surname><given-names>KE</given-names></name><name><surname>Shulman</surname><given-names>LM</given-names></name></person-group><article-title>Effects of optimism/pessimism and locus of control on disability and quality of life in Parkinson's disease</article-title><source>Parkinsonism Rel Disord</source><year>2009</year><volume>15</volume><issue>9</issue><fpage>665</fpage><lpage>9</lpage><pub-id pub-id-type="doi">10.1016/j.parkreldis.2009.03.005</pub-id></element-citation></ref><ref id="CR39"><label>39.</label><element-citation publication-type="journal"><person-group person-group-type="author"><name><surname>Tang</surname><given-names>YY</given-names></name><name><surname>Holzel</surname><given-names>BK</given-names></name><name><surname>Posner</surname><given-names>MI</given-names></name></person-group><article-title>The neuroscience of mindfulness meditation</article-title><source>Nat Rev Neurosci</source><year>2015</year><volume>16</volume><issue>4</issue><fpage>213</fpage><lpage>25</lpage><pub-id pub-id-type="doi">10.1038/nrn3916</pub-id><pub-id pub-id-type="pmid">25783612</pub-id></element-citation></ref><ref id="CR40"><label>40.</label><element-citation publication-type="journal"><person-group person-group-type="author"><name><surname>Pickut</surname><given-names>BA</given-names></name><name><surname>Van Hecke</surname><given-names>W</given-names></name><name><surname>Kerckhofs</surname><given-names>E</given-names></name><name><surname>Marien</surname><given-names>P</given-names></name><name><surname>Vanneste</surname><given-names>S</given-names></name><name><surname>Cras</surname><given-names>P</given-names></name><etal></etal></person-group><article-title>Mindfulness based intervention in Parkinson's disease leads to structural brain changes on MRI: a randomized controlled longitudinal trial</article-title><source>Clin Neurol Neurosurg</source><year>2013</year><volume>115</volume><issue>12</issue><fpage>2419</fpage><lpage>25</lpage><pub-id pub-id-type="doi">10.1016/j.clineuro.2013.10.002</pub-id><pub-id pub-id-type="pmid">24184066</pub-id></element-citation></ref><ref id="CR41"><label>41.</label><element-citation publication-type="journal"><person-group person-group-type="author"><name><surname>Ma</surname><given-names>SH</given-names></name><name><surname>Teasdale</surname><given-names>JD</given-names></name></person-group><article-title>Mindfulness-based cognitive therapy for depression: replication and exploration of differential relapse prevention effects</article-title><source>J Consult Clin Psychol</source><year>2004</year><volume>72</volume><issue>1</issue><fpage>31</fpage><lpage>40</lpage><pub-id pub-id-type="doi">10.1037/0022-006X.72.1.31</pub-id><pub-id pub-id-type="pmid">14756612</pub-id></element-citation></ref><ref id="CR42"><label>42.</label><element-citation publication-type="journal"><person-group person-group-type="author"><name><surname>Grossman</surname><given-names>P</given-names></name><name><surname>Niemann</surname><given-names>L</given-names></name><name><surname>Schmidt</surname><given-names>S</given-names></name><name><surname>Walach</surname><given-names>H</given-names></name></person-group><article-title>Mindfulness-based stress reduction and health benefits</article-title><source>J Psychosom Res</source><year>2004</year><volume>57</volume><issue>1</issue><fpage>35</fpage><lpage>43</lpage><pub-id pub-id-type="doi">10.1016/S0022-3999(03)00573-7</pub-id><pub-id pub-id-type="pmid">15256293</pub-id></element-citation></ref><ref id="CR43"><label>43.</label><element-citation publication-type="journal"><person-group person-group-type="author"><name><surname>Allen</surname><given-names>NB</given-names></name><name><surname>Chambers</surname><given-names>R</given-names></name><name><surname>Knight</surname><given-names>W</given-names></name></person-group><article-title>Mindfulness-based psychotherapies: a review of conceptual foundations, empirical evidence and practical considerations</article-title><source>Aus NZ J Psychiatry</source><year>2006</year><volume>40</volume><issue>4</issue><fpage>285</fpage><lpage>94</lpage><pub-id pub-id-type="doi">10.1111/j.1440-1614.2006.01794.x</pub-id></element-citation></ref><ref id="CR44"><label>44.</label><element-citation publication-type="journal"><person-group person-group-type="author"><name><surname>Souza</surname><given-names>RG</given-names></name><name><surname>Borges</surname><given-names>V</given-names></name><name><surname>Silva</surname><given-names>SMCdA</given-names></name><name><surname>Ferraz</surname><given-names>HB</given-names></name></person-group><article-title>Quality of life scale in parkinson's disease PDQ-39 - (Brazilian Portuguese version) to assess patients with and without levodopa motor fluctuation</article-title><source>Arq Neuropsiquiatr</source><year>2007</year><volume>65</volume><fpage>787</fpage><lpage>91</lpage><pub-id pub-id-type="doi">10.1590/S0004-282X2007000500010</pub-id><pub-id pub-id-type="pmid">17952281</pub-id></element-citation></ref><ref id="CR45"><label>45.</label><mixed-citation publication-type="other">The Parkinson’s Disease and Movement Disorders Centre. What is Parkinson's disease? In: Neurology and Neurosurgery. Johns Hopkins Medicine. 2016. <ext-link ext-link-type="uri" xlink:href="http://www.hopkinsmedicine.org/neurology_neurosurgery/centers_clinics/movement_disorders/conditions/parkinsons_disease.html">http://www.hopkinsmedicine.org/neurology_neurosurgery/centers_clinics/movement_disorders/conditions/parkinsons_disease.html</ext-link>. Accessed 23 May 2016.</mixed-citation></ref><ref id="CR46"><label>46.</label><element-citation publication-type="journal"><person-group person-group-type="author"><name><surname>Murman</surname><given-names>DL</given-names></name></person-group><article-title>Early treatment of Parkinson's disease: opportunities for managed care</article-title><source>Am J Manag Care</source><year>2012</year><volume>18</volume><issue>7 Suppl</issue><fpage>S183</fpage><lpage>8</lpage><pub-id pub-id-type="pmid">23039867</pub-id></element-citation></ref><ref id="CR47"><label>47.</label><element-citation publication-type="journal"><person-group person-group-type="author"><name><surname>Crane</surname><given-names>C</given-names></name><name><surname>Crane</surname><given-names>RS</given-names></name><name><surname>Eames</surname><given-names>C</given-names></name><name><surname>Fennell</surname><given-names>MJV</given-names></name><name><surname>Silverton</surname><given-names>S</given-names></name><name><surname>Williams</surname><given-names>JMG</given-names></name><etal></etal></person-group><article-title>The effects of amount of home meditation practice in mindfulness based cognitive therapy on hazard of relapse to depression in the Staying Well after Depression Trial</article-title><source>Behav Res Ther</source><year>2014</year><volume>63</volume><fpage>17</fpage><lpage>24</lpage><pub-id pub-id-type="doi">10.1016/j.brat.2014.08.015</pub-id><pub-id pub-id-type="pmid">25261599</pub-id></element-citation></ref><ref id="CR48"><label>48.</label><element-citation publication-type="journal"><person-group person-group-type="author"><name><surname>Nyklicek</surname><given-names>I</given-names></name><name><surname>Kuijpers</surname><given-names>KF</given-names></name></person-group><article-title>Effects of mindfulness-based stress reduction intervention on psychological well-being and quality of life: is increased mindfulness indeed the mechanism?</article-title><source>Ann Behav Med</source><year>2008</year><volume>35</volume><issue>3</issue><fpage>331</fpage><lpage>40</lpage><pub-id pub-id-type="doi">10.1007/s12160-008-9030-2</pub-id><pub-id pub-id-type="pmid">18535870</pub-id></element-citation></ref><ref id="CR49"><label>49.</label><element-citation publication-type="journal"><person-group person-group-type="author"><name><surname>Carmody</surname><given-names>J</given-names></name><name><surname>Baer</surname><given-names>RA</given-names></name></person-group><article-title>Relationships between mindfulness practice and levels of mindfulness, medical and psychological symptoms and well-being in a mindfulness-based stress reduction program</article-title><source>J Behav Med</source><year>2008</year><volume>31</volume><issue>1</issue><fpage>23</fpage><lpage>33</lpage><pub-id pub-id-type="doi">10.1007/s10865-007-9130-7</pub-id><pub-id pub-id-type="pmid">17899351</pub-id></element-citation></ref><ref id="CR50"><label>50.</label><element-citation publication-type="journal"><person-group person-group-type="author"><name><surname>Cash</surname><given-names>T</given-names></name><name><surname>Ekouevi</surname><given-names>V</given-names></name><name><surname>Kilbourn</surname><given-names>C</given-names></name><name><surname>Lageman</surname><given-names>S</given-names></name></person-group><article-title>Pilot study of a mindfulness-based group intervention for individuals with Parkinson’s disease and their caregivers</article-title><source>Mindfulness</source><year>2015</year><volume>7</volume><issue>2</issue><fpage>361</fpage><lpage>71</lpage><pub-id pub-id-type="doi">10.1007/s12671-015-0452-1</pub-id></element-citation></ref><ref id="CR51"><label>51.</label><element-citation publication-type="journal"><person-group person-group-type="author"><name><surname>Delgado-Rodríguez</surname><given-names>M</given-names></name><name><surname>Llorca</surname><given-names>J</given-names></name></person-group><article-title>Bias</article-title><source>J Epidemiol Community Health</source><year>2004</year><volume>58</volume><issue>8</issue><fpage>635</fpage><lpage>41</lpage><pub-id pub-id-type="doi">10.1136/jech.2003.008466</pub-id><pub-id pub-id-type="pmid">15252064</pub-id></element-citation></ref><ref id="CR52"><label>52.</label><element-citation publication-type="book"><person-group person-group-type="author"><name><surname>Jenkinson</surname><given-names>C</given-names></name><name><surname>Fitzpatrick</surname><given-names>R</given-names></name><name><surname>Peto</surname><given-names>V</given-names></name><name><surname>Harris</surname><given-names>R</given-names></name><name><surname>Saunders</surname><given-names>P</given-names></name></person-group><source>The Parkinson's disease questionaire: PDQ-39 user manual</source><year>2008</year><publisher-loc>Oxford</publisher-loc><publisher-name>Health Services Research Unit, University of Oxford</publisher-name></element-citation></ref><ref id="CR53"><label>53.</label><element-citation publication-type="journal"><person-group person-group-type="author"><name><surname>Kim</surname><given-names>M</given-names></name><name><surname>Dahlberg</surname><given-names>A</given-names></name><name><surname>Hagell</surname><given-names>P</given-names></name></person-group><article-title>Respondent burden and patient-perceived validity of the PDQ-39</article-title><source>Acta Neurol Scand</source><year>2006</year><volume>113</volume><fpage>132</fpage><lpage>7</lpage><pub-id pub-id-type="doi">10.1111/j.1600-0404.2005.00549.x</pub-id><pub-id pub-id-type="pmid">16411975</pub-id></element-citation></ref><ref id="CR54"><label>54.</label><element-citation publication-type="journal"><person-group person-group-type="author"><name><surname>Johnson</surname><given-names>AR</given-names></name><name><surname>Lawrence</surname><given-names>BJ</given-names></name><name><surname>Corti</surname><given-names>EJ</given-names></name><name><surname>Booth</surname><given-names>L</given-names></name><name><surname>Gasson</surname><given-names>N</given-names></name><name><surname>Thomas</surname><given-names>MG</given-names></name><etal></etal></person-group><article-title>Suitability of the Depression, Anxiety, and Stress Scale in Parkinson’s disease</article-title><source>J Parkinsons Dis</source><year>2016</year><pub-id pub-id-type="pmid">27258699</pub-id></element-citation></ref></ref-list></back></pmc></record>Pour manipuler ce document sous Unix (Dilib)
EXPLOR_STEP=$WICRI_ROOT/Wicri/Canada/explor/ParkinsonCanadaV1/Data/Pmc/Corpus
HfdSelect -h $EXPLOR_STEP/biblio.hfd -nk 000238 | SxmlIndent | more
Ou
HfdSelect -h $EXPLOR_AREA/Data/Pmc/Corpus/biblio.hfd -nk 000238 | SxmlIndent | more
Pour mettre un lien sur cette page dans le réseau Wicri
{{Explor lien
|wiki= Wicri/Canada
|area= ParkinsonCanadaV1
|flux= Pmc
|étape= Corpus
|type= RBID
|clé=
|texte=
}}
| This area was generated with Dilib version V0.6.29. |  |