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<record><TEI><teiHeader><fileDesc><titleStmt><title xml:lang="en">Genetic perspective on the role of the autophagy-lysosome pathway in Parkinson disease</title><author><name sortKey="Gan Or, Ziv" sort="Gan Or, Ziv" uniqKey="Gan Or Z" first="Ziv" last="Gan-Or">Ziv Gan-Or</name><affiliation><nlm:aff id="af0001"><institution>The Department of Human Genetics; McGill University</institution>; Montreal, QC<country>Canada</country></nlm:aff></affiliation><affiliation><nlm:aff id="af0002"><institution>Montreal Neurological Institute; McGill University</institution>; Montreal, QC<country>Canada</country></nlm:aff></affiliation></author><author><name sortKey="Dion, Patrick A" sort="Dion, Patrick A" uniqKey="Dion P" first="Patrick A" last="Dion">Patrick A. Dion</name><affiliation><nlm:aff id="af0001"><institution>The Department of Human Genetics; McGill University</institution>; Montreal, QC<country>Canada</country></nlm:aff></affiliation><affiliation><nlm:aff id="af0002"><institution>Montreal Neurological Institute; McGill University</institution>; Montreal, QC<country>Canada</country></nlm:aff></affiliation><affiliation><nlm:aff id="af0003"><institution>The Department of Neurology & Neurosurgery; McGill University</institution>; Montreal, QC<country>Canada</country></nlm:aff></affiliation></author><author><name sortKey="Rouleau, Guy A" sort="Rouleau, Guy A" uniqKey="Rouleau G" first="Guy A" last="Rouleau">Guy A. Rouleau</name><affiliation><nlm:aff id="af0001"><institution>The Department of Human Genetics; McGill University</institution>; Montreal, QC<country>Canada</country></nlm:aff></affiliation><affiliation><nlm:aff id="af0002"><institution>Montreal Neurological Institute; McGill University</institution>; Montreal, QC<country>Canada</country></nlm:aff></affiliation><affiliation><nlm:aff id="af0003"><institution>The Department of Neurology & Neurosurgery; McGill University</institution>; Montreal, QC<country>Canada</country></nlm:aff></affiliation></author></titleStmt><publicationStmt><idno type="wicri:source">PMC</idno><idno type="pmid">26207393</idno><idno type="pmc">4590678</idno><idno type="url">http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4590678</idno><idno type="RBID">PMC:4590678</idno><idno type="doi">10.1080/15548627.2015.1067364</idno><date when="2015">2015</date><idno type="wicri:Area/Pmc/Corpus">000103</idno><idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Corpus" wicri:corpus="PMC">000103</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en" level="a" type="main">Genetic perspective on the role of the autophagy-lysosome pathway in Parkinson disease</title><author><name sortKey="Gan Or, Ziv" sort="Gan Or, Ziv" uniqKey="Gan Or Z" first="Ziv" last="Gan-Or">Ziv Gan-Or</name><affiliation><nlm:aff id="af0001"><institution>The Department of Human Genetics; McGill University</institution>; Montreal, QC<country>Canada</country></nlm:aff></affiliation><affiliation><nlm:aff id="af0002"><institution>Montreal Neurological Institute; McGill University</institution>; Montreal, QC<country>Canada</country></nlm:aff></affiliation></author><author><name sortKey="Dion, Patrick A" sort="Dion, Patrick A" uniqKey="Dion P" first="Patrick A" last="Dion">Patrick A. Dion</name><affiliation><nlm:aff id="af0001"><institution>The Department of Human Genetics; McGill University</institution>; Montreal, QC<country>Canada</country></nlm:aff></affiliation><affiliation><nlm:aff id="af0002"><institution>Montreal Neurological Institute; McGill University</institution>; Montreal, QC<country>Canada</country></nlm:aff></affiliation><affiliation><nlm:aff id="af0003"><institution>The Department of Neurology & Neurosurgery; McGill University</institution>; Montreal, QC<country>Canada</country></nlm:aff></affiliation></author><author><name sortKey="Rouleau, Guy A" sort="Rouleau, Guy A" uniqKey="Rouleau G" first="Guy A" last="Rouleau">Guy A. Rouleau</name><affiliation><nlm:aff id="af0001"><institution>The Department of Human Genetics; McGill University</institution>; Montreal, QC<country>Canada</country></nlm:aff></affiliation><affiliation><nlm:aff id="af0002"><institution>Montreal Neurological Institute; McGill University</institution>; Montreal, QC<country>Canada</country></nlm:aff></affiliation><affiliation><nlm:aff id="af0003"><institution>The Department of Neurology & Neurosurgery; McGill University</institution>; Montreal, QC<country>Canada</country></nlm:aff></affiliation></author></analytic><series><title level="j">Autophagy</title><idno type="ISSN">1554-8627</idno><idno type="eISSN">1554-8635</idno><imprint><date when="2015">2015</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en"><p>Parkinson disease (PD), once considered as a prototype of a sporadic disease, is now known to be considerably affected by various genetic factors, which interact with environmental factors and the normal process of aging, leading to PD. Large studies determined that the hereditary component of PD is at least 27%, and in some populations, single genetic factors are responsible for more than 33% of PD patients. Interestingly, many of these genetic factors, such as <italic>LRRK2</italic>, <italic>GBA</italic>, <italic>SMPD1</italic>, <italic>SNCA</italic>, <italic>PARK2</italic>, <italic>PINK1</italic>, <italic>PARK7</italic>, <italic>SCARB2</italic>, and others, are involved in the autophagy-lysosome pathway (ALP). Some of these genes encode lysosomal enzymes, whereas others correspond to proteins that are involved in transport to the lysosome, mitophagy, or other autophagic-related functions. Is it possible that all these factors converge into a single pathway that causes PD? In this review, we will discuss these genetic findings and the role of the ALP in the pathogenesis of PD and will try to answer this question. We will suggest a novel hypothesis for the pathogenic mechanism of PD that involves the lysosome and the different autophagy pathways.</p></div></front></TEI><pmc article-type="review-article"><pmc-comment>The publisher of this article does not allow downloading of the full text in XML form.</pmc-comment>
<front><journal-meta><journal-id journal-id-type="nlm-ta">Autophagy</journal-id><journal-id journal-id-type="iso-abbrev">Autophagy</journal-id><journal-id journal-id-type="pmc">KAUP</journal-id><journal-title-group><journal-title>Autophagy</journal-title></journal-title-group><issn pub-type="ppub">1554-8627</issn><issn pub-type="epub">1554-8635</issn><publisher><publisher-name>Taylor & Francis</publisher-name></publisher></journal-meta><article-meta><article-id pub-id-type="pmid">26207393</article-id><article-id pub-id-type="pmc">4590678</article-id><article-id pub-id-type="publisher-id">1067364</article-id><article-id pub-id-type="doi">10.1080/15548627.2015.1067364</article-id><article-categories><subj-group subj-group-type="heading"><subject>Review</subject></subj-group></article-categories><title-group><article-title>Genetic perspective on the role of the autophagy-lysosome pathway in Parkinson disease</article-title></title-group><contrib-group><contrib contrib-type="author"><name><surname>Gan-Or</surname><given-names>Ziv</given-names></name><xref ref-type="aff" rid="af0001"><sup>1</sup></xref><xref ref-type="aff" rid="af0002"><sup>2</sup></xref><xref ref-type="corresp" rid="an0001"><sup>*</sup></xref></contrib><contrib contrib-type="author"><name><surname>Dion</surname><given-names>Patrick A</given-names></name><xref ref-type="aff" rid="af0001"><sup>1</sup></xref><xref ref-type="aff" rid="af0002"><sup>2</sup></xref><xref ref-type="aff" rid="af0003"><sup>3</sup></xref></contrib><contrib contrib-type="author"><name><surname>Rouleau</surname><given-names>Guy A</given-names></name><xref ref-type="aff" rid="af0001"><sup>1</sup></xref><xref ref-type="aff" rid="af0002"><sup>2</sup></xref><xref ref-type="aff" rid="af0003"><sup>3</sup></xref></contrib><aff id="af0001"><label>1</label><institution>The Department of Human Genetics; McGill University</institution>; Montreal, QC<country>Canada</country></aff><aff id="af0002"><label>2</label><institution>Montreal Neurological Institute; McGill University</institution>; Montreal, QC<country>Canada</country></aff><aff id="af0003"><label>3</label><institution>The Department of Neurology & Neurosurgery; McGill University</institution>; Montreal, QC<country>Canada</country></aff></contrib-group><author-notes><corresp id="an0001"><label>*</label>Correspondence to: Ziv Gan-Or; Email: <email xlink:href="ziv.gan-or@mcgill.ca">ziv.gan-or@mcgill.ca</email></corresp></author-notes><pub-date pub-type="collection"><month>9</month><year>2015</year></pub-date><pub-date pub-type="epub"><day>24</day><month>7</month><year>2015</year></pub-date><volume>11</volume><issue>9</issue><fpage seq="2">1443</fpage><lpage>1457</lpage><history><date date-type="received"><day>31</day><month>3</month><year>2015</year></date><date date-type="rev-recd"><day>10</day><month>6</month><year>2015</year></date><date date-type="accepted"><day>24</day><month>6</month><year>2015</year></date></history><permissions><copyright-statement>© 2015 Taylor & Francis Group, LLC</copyright-statement><copyright-year>2015</copyright-year><copyright-holder>Taylor & Francis Group, LLC</copyright-holder></permissions><self-uri content-type="pdf" xlink:href="kaup-11-09-1067364.pdf"></self-uri><abstract><p>Parkinson disease (PD), once considered as a prototype of a sporadic disease, is now known to be considerably affected by various genetic factors, which interact with environmental factors and the normal process of aging, leading to PD. Large studies determined that the hereditary component of PD is at least 27%, and in some populations, single genetic factors are responsible for more than 33% of PD patients. Interestingly, many of these genetic factors, such as <italic>LRRK2</italic>, <italic>GBA</italic>, <italic>SMPD1</italic>, <italic>SNCA</italic>, <italic>PARK2</italic>, <italic>PINK1</italic>, <italic>PARK7</italic>, <italic>SCARB2</italic>, and others, are involved in the autophagy-lysosome pathway (ALP). Some of these genes encode lysosomal enzymes, whereas others correspond to proteins that are involved in transport to the lysosome, mitophagy, or other autophagic-related functions. Is it possible that all these factors converge into a single pathway that causes PD? In this review, we will discuss these genetic findings and the role of the ALP in the pathogenesis of PD and will try to answer this question. We will suggest a novel hypothesis for the pathogenic mechanism of PD that involves the lysosome and the different autophagy pathways.</p></abstract><kwd-group kwd-group-type="author"><title>Keywords</title><kwd>autophagy</kwd><kwd>GBA</kwd><kwd>genetics</kwd><kwd>LRRK2</kwd><kwd>LAMP2A</kwd><kwd>lysosome</kwd><kwd>mitophagy</kwd><kwd>Parkinson disease</kwd><kwd>SNCA</kwd></kwd-group><counts><fig-count count="2"></fig-count><table-count count="0"></table-count><ref-count count="208"></ref-count><page-count count="15"></page-count></counts></article-meta></front></pmc></record>Pour manipuler ce document sous Unix (Dilib)
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