Dorsolateral Prefrontal Cortex Deactivation in Monkeys Reduces Preparatory Beta and Gamma Power in the Superior Colliculus
Identifieur interne : 000031 ( Pmc/Corpus ); précédent : 000030; suivant : 000032Dorsolateral Prefrontal Cortex Deactivation in Monkeys Reduces Preparatory Beta and Gamma Power in the Superior Colliculus
Auteurs : Jason L. Chan ; Michael J. Koval ; Thilo Womelsdorf ; Stephen G. Lomber ; Stefan EverlingSource :
- Cerebral Cortex (New York, NY) [ 1047-3211 ] ; 2014.
Abstract
Cognitive control requires the selection and maintenance of task-relevant stimulus–response associations, or rules. The dorsolateral prefrontal cortex (DLPFC) has been implicated by lesion, functional imaging, and neurophysiological studies to be involved in encoding rules, but the mechanisms by which it modulates other brain areas are poorly understood. Here, the functional relationship of the DLPFC with the superior colliculus (SC) was investigated by bilaterally deactivating the DLPFC while recording local field potentials (LFPs) in the SC in monkeys performing an interleaved pro- and antisaccade task. Event-related LFPs showed differences between pro- and antisaccades and responded prominently to stimulus presentation. LFP power after stimulus onset was higher for correct saccades than erroneous saccades. Deactivation of the DLPFC did not affect stimulus onset related LFP activity, but reduced high beta (20–30 Hz) and high gamma (60–150 Hz) power during the preparatory period for both pro- and antisaccades. Spike rate during the preparatory period was positively correlated with gamma power and this relationship was attenuated by DLPFC deactivation. These results suggest that top-down control of the SC by the DLPFC may be mediated by beta oscillations.
Url:
DOI: 10.1093/cercor/bhu154
PubMed: 25037923
PubMed Central: 4635915
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Koval</name><affiliation><nlm:aff id="af1"><addr-line>Graduate Program in Neuroscience</addr-line></nlm:aff></affiliation></author><author><name sortKey="Womelsdorf, Thilo" sort="Womelsdorf, Thilo" uniqKey="Womelsdorf T" first="Thilo" last="Womelsdorf">Thilo Womelsdorf</name><affiliation><nlm:aff id="af4"><addr-line>Department of Biology</addr-line>,<institution>Centre for Vision Research, York University</institution>,<addr-line>Toronto, ON</addr-line>,<country>Canada</country><addr-line>M3J 1P3</addr-line></nlm:aff></affiliation></author><author><name sortKey="Lomber, Stephen G" sort="Lomber, Stephen G" uniqKey="Lomber S" first="Stephen G." last="Lomber">Stephen G. Lomber</name><affiliation><nlm:aff id="af1"><addr-line>Graduate Program in Neuroscience</addr-line></nlm:aff></affiliation><affiliation><nlm:aff id="af2"><addr-line>Department of Physiology and Pharmacology</addr-line></nlm:aff></affiliation><affiliation><nlm:aff id="af3"><addr-line>Department of Psychology</addr-line>,<institution>University of Western Ontario</institution>,<addr-line>London, ON</addr-line>,<country>Canada</country><addr-line>N6A 3K7</addr-line></nlm:aff></affiliation></author><author><name sortKey="Everling, Stefan" sort="Everling, Stefan" uniqKey="Everling S" first="Stefan" last="Everling">Stefan Everling</name><affiliation><nlm:aff id="af1"><addr-line>Graduate Program in Neuroscience</addr-line></nlm:aff></affiliation><affiliation><nlm:aff id="af2"><addr-line>Department of Physiology and Pharmacology</addr-line></nlm:aff></affiliation><affiliation><nlm:aff id="af3"><addr-line>Department of Psychology</addr-line>,<institution>University of Western Ontario</institution>,<addr-line>London, ON</addr-line>,<country>Canada</country><addr-line>N6A 3K7</addr-line></nlm:aff></affiliation><affiliation><nlm:aff id="af5"><institution>Robarts Research Institute</institution>,<addr-line>London, ON</addr-line>,<country>Canada</country><addr-line>N6A 5B7</addr-line></nlm:aff></affiliation></author></titleStmt><publicationStmt><idno type="wicri:source">PMC</idno><idno type="pmid">25037923</idno><idno type="pmc">4635915</idno><idno type="url">http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4635915</idno><idno type="RBID">PMC:4635915</idno><idno type="doi">10.1093/cercor/bhu154</idno><date when="2014">2014</date><idno type="wicri:Area/Pmc/Corpus">000031</idno><idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Corpus" wicri:corpus="PMC">000031</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en" level="a" type="main">Dorsolateral Prefrontal Cortex Deactivation in Monkeys Reduces Preparatory Beta and Gamma Power in the Superior Colliculus</title><author><name sortKey="Chan, Jason L" sort="Chan, Jason L" uniqKey="Chan J" first="Jason L." last="Chan">Jason L. Chan</name><affiliation><nlm:aff id="af1"><addr-line>Graduate Program in Neuroscience</addr-line></nlm:aff></affiliation></author><author><name sortKey="Koval, Michael J" sort="Koval, Michael J" uniqKey="Koval M" first="Michael J." last="Koval">Michael J. Koval</name><affiliation><nlm:aff id="af1"><addr-line>Graduate Program in Neuroscience</addr-line></nlm:aff></affiliation></author><author><name sortKey="Womelsdorf, Thilo" sort="Womelsdorf, Thilo" uniqKey="Womelsdorf T" first="Thilo" last="Womelsdorf">Thilo Womelsdorf</name><affiliation><nlm:aff id="af4"><addr-line>Department of Biology</addr-line>,<institution>Centre for Vision Research, York University</institution>,<addr-line>Toronto, ON</addr-line>,<country>Canada</country><addr-line>M3J 1P3</addr-line></nlm:aff></affiliation></author><author><name sortKey="Lomber, Stephen G" sort="Lomber, Stephen G" uniqKey="Lomber S" first="Stephen G." last="Lomber">Stephen G. Lomber</name><affiliation><nlm:aff id="af1"><addr-line>Graduate Program in Neuroscience</addr-line></nlm:aff></affiliation><affiliation><nlm:aff id="af2"><addr-line>Department of Physiology and Pharmacology</addr-line></nlm:aff></affiliation><affiliation><nlm:aff id="af3"><addr-line>Department of Psychology</addr-line>,<institution>University of Western Ontario</institution>,<addr-line>London, ON</addr-line>,<country>Canada</country><addr-line>N6A 3K7</addr-line></nlm:aff></affiliation></author><author><name sortKey="Everling, Stefan" sort="Everling, Stefan" uniqKey="Everling S" first="Stefan" last="Everling">Stefan Everling</name><affiliation><nlm:aff id="af1"><addr-line>Graduate Program in Neuroscience</addr-line></nlm:aff></affiliation><affiliation><nlm:aff id="af2"><addr-line>Department of Physiology and Pharmacology</addr-line></nlm:aff></affiliation><affiliation><nlm:aff id="af3"><addr-line>Department of Psychology</addr-line>,<institution>University of Western Ontario</institution>,<addr-line>London, ON</addr-line>,<country>Canada</country><addr-line>N6A 3K7</addr-line></nlm:aff></affiliation><affiliation><nlm:aff id="af5"><institution>Robarts Research Institute</institution>,<addr-line>London, ON</addr-line>,<country>Canada</country><addr-line>N6A 5B7</addr-line></nlm:aff></affiliation></author></analytic><series><title level="j">Cerebral Cortex (New York, NY)</title><idno type="ISSN">1047-3211</idno><idno type="eISSN">1460-2199</idno><imprint><date when="2014">2014</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en"><p>Cognitive control requires the selection and maintenance of task-relevant stimulus–response associations, or rules. The dorsolateral prefrontal cortex (DLPFC) has been implicated by lesion, functional imaging, and neurophysiological studies to be involved in encoding rules, but the mechanisms by which it modulates other brain areas are poorly understood. Here, the functional relationship of the DLPFC with the superior colliculus (SC) was investigated by bilaterally deactivating the DLPFC while recording local field potentials (LFPs) in the SC in monkeys performing an interleaved pro- and antisaccade task. Event-related LFPs showed differences between pro- and antisaccades and responded prominently to stimulus presentation. LFP power after stimulus onset was higher for correct saccades than erroneous saccades. Deactivation of the DLPFC did not affect stimulus onset related LFP activity, but reduced high beta (20–30 Hz) and high gamma (60–150 Hz) power during the preparatory period for both pro- and antisaccades. Spike rate during the preparatory period was positively correlated with gamma power and this relationship was attenuated by DLPFC deactivation. These results suggest that top-down control of the SC by the DLPFC may be mediated by beta oscillations.</p></div></front></TEI><pmc article-type="research-article"><pmc-comment>The publisher of this article does not allow downloading of the full text in XML form.</pmc-comment>
<front><journal-meta><journal-id journal-id-type="nlm-ta">Cereb Cortex</journal-id><journal-id journal-id-type="iso-abbrev">Cereb. Cortex</journal-id><journal-id journal-id-type="publisher-id">cercor</journal-id><journal-id journal-id-type="hwp">cercor</journal-id><journal-title-group><journal-title>Cerebral Cortex (New York, NY)</journal-title></journal-title-group><issn pub-type="ppub">1047-3211</issn><issn pub-type="epub">1460-2199</issn><publisher><publisher-name>Oxford University Press</publisher-name></publisher></journal-meta><article-meta><article-id pub-id-type="pmid">25037923</article-id><article-id pub-id-type="pmc">4635915</article-id><article-id pub-id-type="doi">10.1093/cercor/bhu154</article-id><article-id pub-id-type="publisher-id">bhu154</article-id><article-categories><subj-group subj-group-type="heading"><subject>Articles</subject></subj-group></article-categories><title-group><article-title>Dorsolateral Prefrontal Cortex Deactivation in Monkeys Reduces Preparatory Beta and Gamma Power in the Superior Colliculus</article-title></title-group><contrib-group><contrib contrib-type="author"><name><surname>Chan</surname><given-names>Jason L.</given-names></name><xref ref-type="aff" rid="af1">1</xref></contrib><contrib contrib-type="author"><name><surname>Koval</surname><given-names>Michael J.</given-names></name><xref ref-type="aff" rid="af1">1</xref></contrib><contrib contrib-type="author"><name><surname>Womelsdorf</surname><given-names>Thilo</given-names></name><xref ref-type="aff" rid="af4">4</xref></contrib><contrib contrib-type="author"><name><surname>Lomber</surname><given-names>Stephen G.</given-names></name><xref ref-type="aff" rid="af1">1</xref><xref ref-type="aff" rid="af2">2</xref><xref ref-type="aff" rid="af3">3</xref></contrib><contrib contrib-type="author"><name><surname>Everling</surname><given-names>Stefan</given-names></name><xref ref-type="aff" rid="af1">1</xref><xref ref-type="aff" rid="af2">2</xref><xref ref-type="aff" rid="af3">3</xref><xref ref-type="aff" rid="af5">5</xref></contrib><aff id="af1"><label>1</label><addr-line>Graduate Program in Neuroscience</addr-line></aff><aff id="af2"><label>2</label><addr-line>Department of Physiology and Pharmacology</addr-line></aff><aff id="af3"><label>3</label><addr-line>Department of Psychology</addr-line>,<institution>University of Western Ontario</institution>,<addr-line>London, ON</addr-line>,<country>Canada</country><addr-line>N6A 3K7</addr-line></aff><aff id="af4"><label>4</label><addr-line>Department of Biology</addr-line>,<institution>Centre for Vision Research, York University</institution>,<addr-line>Toronto, ON</addr-line>,<country>Canada</country><addr-line>M3J 1P3</addr-line></aff><aff id="af5"><label>5</label><institution>Robarts Research Institute</institution>,<addr-line>London, ON</addr-line>,<country>Canada</country><addr-line>N6A 5B7</addr-line></aff></contrib-group><author-notes><corresp>Address correspondence to Stefan Everling, Robarts Research Institute, 1151 Richmond Street North, London, Ontario, Canada N6A 5B7. Email: <email>severlin@uwo.ca</email></corresp></author-notes><pub-date pub-type="ppub"><month>12</month><year>2015</year></pub-date><pub-date pub-type="epub"><day>17</day><month>7</month><year>2014</year></pub-date><pub-date pub-type="pmc-release"><day>1</day><month>12</month><year>2016</year></pub-date><pmc-comment> PMC Release delay is 12 months and
0 days and was based on the
<volume>25</volume><issue>12</issue><fpage>4704</fpage><lpage>4714</lpage><permissions><copyright-statement>© The Author 2014. Published by Oxford University Press. All rights reserved. For Permissions, please e-mail: journals.permissions@oup.com</copyright-statement><copyright-year>2014</copyright-year></permissions><self-uri content-type="pdf" xlink:type="simple" xlink:href="bhu154.pdf"></self-uri><abstract><p>Cognitive control requires the selection and maintenance of task-relevant stimulus–response associations, or rules. The dorsolateral prefrontal cortex (DLPFC) has been implicated by lesion, functional imaging, and neurophysiological studies to be involved in encoding rules, but the mechanisms by which it modulates other brain areas are poorly understood. Here, the functional relationship of the DLPFC with the superior colliculus (SC) was investigated by bilaterally deactivating the DLPFC while recording local field potentials (LFPs) in the SC in monkeys performing an interleaved pro- and antisaccade task. Event-related LFPs showed differences between pro- and antisaccades and responded prominently to stimulus presentation. LFP power after stimulus onset was higher for correct saccades than erroneous saccades. Deactivation of the DLPFC did not affect stimulus onset related LFP activity, but reduced high beta (20–30 Hz) and high gamma (60–150 Hz) power during the preparatory period for both pro- and antisaccades. Spike rate during the preparatory period was positively correlated with gamma power and this relationship was attenuated by DLPFC deactivation. These results suggest that top-down control of the SC by the DLPFC may be mediated by beta oscillations.</p></abstract><kwd-group><kwd>antisaccade</kwd><kwd>cortical deactivation</kwd><kwd>local field potential</kwd><kwd>oscillation</kwd><kwd>top-down control</kwd></kwd-group></article-meta></front></pmc></record>Pour manipuler ce document sous Unix (Dilib)
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