Electrical Stimulation of the Insular Region Attenuates Nicotine-Taking and Nicotine-Seeking Behaviors
Identifieur interne : 000010 ( Pmc/Corpus ); précédent : 000009; suivant : 000011Electrical Stimulation of the Insular Region Attenuates Nicotine-Taking and Nicotine-Seeking Behaviors
Auteurs : Abhiram Pushparaj ; Clement Hamani ; Wilson Yu ; Damian S. Shin ; Bin Kang ; José N. Nobrega ; Bernard Le FollSource :
- Neuropsychopharmacology [ 0893-133X ] ; 2012.
Abstract
Pharmacological inactivation of the granular insular cortex is able to block nicotine-taking and -seeking behaviors in rats. In this study, we explored the potential of modulating activity in the insular region using electrical stimulation. Animals were trained to self-administer nicotine (0.03 mg/kg per infusion) under a fixed ratio-5 (FR-5) schedule of reinforcement followed by a progressive ratio (PR) schedule. Evaluation of the effect of stimulation in the insular region was performed on nicotine self-administration under FR-5 and PR schedules, as well on reinstatement of nicotine-seeking behavior induced by nicotine-associated cues or nicotine-priming injections. The effect of stimulation was also examined in brain slices containing insular neurons. Stimulation significantly attenuated nicotine-taking, under both schedules of reinforcement, as well as nicotine-seeking behavior induced by cues and priming. These effects appear to be specific to nicotine-associated behaviors, as stimulation did not have any effect on food-taking behavior. They appear to be anatomically specific, as stimulation surrounding the insular region had no effect on behavior. Stimulation of brain slices containing the insular region was found to inactivate insular neurons. Our results suggest that deep brain stimulation to modulate insular activity should be further explored.
Url:
DOI: 10.1038/npp.2012.235
PubMed: 23249816
PubMed Central: 3572467
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Shin</name><affiliation><nlm:aff id="aff4"><institution>Center for Neuropharmacology and Neuroscience, Albany Medical College</institution>, Albany, NY,<country>USA</country></nlm:aff></affiliation></author><author><name sortKey="Kang, Bin" sort="Kang, Bin" uniqKey="Kang B" first="Bin" last="Kang">Bin Kang</name><affiliation><nlm:aff id="aff1"><institution>Translational Addiction Research Laboratory, Campbell Family Mental Health Research Institute, Centre for Addiction and Mental Health (CAMH)</institution>, Toronto, ON,<country>Canada</country></nlm:aff></affiliation></author><author><name sortKey="Nobrega, Jose N" sort="Nobrega, Jose N" uniqKey="Nobrega J" first="José N" last="Nobrega">José N. Nobrega</name><affiliation><nlm:aff id="aff2"><institution>Research Imaging Centre, Campbell Family Mental Health Research Institute, Centre for Addiction and Mental Health</institution>, Toronto, ON,<country>Canada</country></nlm:aff></affiliation><affiliation><nlm:aff id="aff5"><institution>Departments of Psychiatry, Pharmacology, Psychology, University of Toronto</institution>, Toronto, ON,<country>Canada</country></nlm:aff></affiliation></author><author><name sortKey="Le Foll, Bernard" sort="Le Foll, Bernard" uniqKey="Le Foll B" first="Bernard" last="Le Foll">Bernard Le Foll</name><affiliation><nlm:aff id="aff1"><institution>Translational Addiction Research Laboratory, Campbell Family Mental Health Research Institute, Centre for Addiction and Mental Health (CAMH)</institution>, Toronto, ON,<country>Canada</country></nlm:aff></affiliation><affiliation><nlm:aff id="aff6"><institution>Departments of Family and Community Medicine, Pharmacology, Psychiatry, Institute of Medical Sciences, University of Toronto</institution>, Toronto,<country>Canada</country></nlm:aff></affiliation><affiliation><nlm:aff id="aff7"><institution>Addiction Program, Centre for Addiction and Mental Health</institution>, Toronto, ON,<country>Canada</country></nlm:aff></affiliation></author></titleStmt><publicationStmt><idno type="wicri:source">PMC</idno><idno type="pmid">23249816</idno><idno type="pmc">3572467</idno><idno type="url">http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3572467</idno><idno type="RBID">PMC:3572467</idno><idno type="doi">10.1038/npp.2012.235</idno><date when="2012">2012</date><idno type="wicri:Area/Pmc/Corpus">000010</idno><idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Corpus" wicri:corpus="PMC">000010</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en" level="a" type="main">Electrical Stimulation of the Insular Region Attenuates Nicotine-Taking and Nicotine-Seeking Behaviors</title><author><name sortKey="Pushparaj, Abhiram" sort="Pushparaj, Abhiram" uniqKey="Pushparaj A" first="Abhiram" last="Pushparaj">Abhiram Pushparaj</name><affiliation><nlm:aff id="aff1"><institution>Translational Addiction Research Laboratory, Campbell Family Mental Health Research Institute, Centre for Addiction and Mental Health (CAMH)</institution>, Toronto, ON,<country>Canada</country></nlm:aff></affiliation></author><author><name sortKey="Hamani, Clement" sort="Hamani, Clement" uniqKey="Hamani C" first="Clement" last="Hamani">Clement Hamani</name><affiliation><nlm:aff id="aff2"><institution>Research Imaging Centre, Campbell Family Mental Health Research Institute, Centre for Addiction and Mental Health</institution>, Toronto, ON,<country>Canada</country></nlm:aff></affiliation><affiliation><nlm:aff id="aff3"><institution>Division of Neurosurgery, Toronto Western Hospital</institution>, Toronto, ON,<country>Canada</country></nlm:aff></affiliation></author><author><name sortKey="Yu, Wilson" sort="Yu, Wilson" uniqKey="Yu W" first="Wilson" last="Yu">Wilson Yu</name><affiliation><nlm:aff id="aff4"><institution>Center for Neuropharmacology and Neuroscience, Albany Medical College</institution>, Albany, NY,<country>USA</country></nlm:aff></affiliation></author><author><name sortKey="Shin, Damian S" sort="Shin, Damian S" uniqKey="Shin D" first="Damian S" last="Shin">Damian S. Shin</name><affiliation><nlm:aff id="aff4"><institution>Center for Neuropharmacology and Neuroscience, Albany Medical College</institution>, Albany, NY,<country>USA</country></nlm:aff></affiliation></author><author><name sortKey="Kang, Bin" sort="Kang, Bin" uniqKey="Kang B" first="Bin" last="Kang">Bin Kang</name><affiliation><nlm:aff id="aff1"><institution>Translational Addiction Research Laboratory, Campbell Family Mental Health Research Institute, Centre for Addiction and Mental Health (CAMH)</institution>, Toronto, ON,<country>Canada</country></nlm:aff></affiliation></author><author><name sortKey="Nobrega, Jose N" sort="Nobrega, Jose N" uniqKey="Nobrega J" first="José N" last="Nobrega">José N. Nobrega</name><affiliation><nlm:aff id="aff2"><institution>Research Imaging Centre, Campbell Family Mental Health Research Institute, Centre for Addiction and Mental Health</institution>, Toronto, ON,<country>Canada</country></nlm:aff></affiliation><affiliation><nlm:aff id="aff5"><institution>Departments of Psychiatry, Pharmacology, Psychology, University of Toronto</institution>, Toronto, ON,<country>Canada</country></nlm:aff></affiliation></author><author><name sortKey="Le Foll, Bernard" sort="Le Foll, Bernard" uniqKey="Le Foll B" first="Bernard" last="Le Foll">Bernard Le Foll</name><affiliation><nlm:aff id="aff1"><institution>Translational Addiction Research Laboratory, Campbell Family Mental Health Research Institute, Centre for Addiction and Mental Health (CAMH)</institution>, Toronto, ON,<country>Canada</country></nlm:aff></affiliation><affiliation><nlm:aff id="aff6"><institution>Departments of Family and Community Medicine, Pharmacology, Psychiatry, Institute of Medical Sciences, University of Toronto</institution>, Toronto,<country>Canada</country></nlm:aff></affiliation><affiliation><nlm:aff id="aff7"><institution>Addiction Program, Centre for Addiction and Mental Health</institution>, Toronto, ON,<country>Canada</country></nlm:aff></affiliation></author></analytic><series><title level="j">Neuropsychopharmacology</title><idno type="ISSN">0893-133X</idno><idno type="eISSN">1740-634X</idno><imprint><date when="2012">2012</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en"><p>Pharmacological inactivation of the granular insular cortex is able to block nicotine-taking and -seeking behaviors in rats. In this study, we explored the potential of modulating activity in the insular region using electrical stimulation. Animals were trained to self-administer nicotine (0.03 mg/kg per infusion) under a fixed ratio-5 (FR-5) schedule of reinforcement followed by a progressive ratio (PR) schedule. Evaluation of the effect of stimulation in the insular region was performed on nicotine self-administration under FR-5 and PR schedules, as well on reinstatement of nicotine-seeking behavior induced by nicotine-associated cues or nicotine-priming injections. The effect of stimulation was also examined in brain slices containing insular neurons. Stimulation significantly attenuated nicotine-taking, under both schedules of reinforcement, as well as nicotine-seeking behavior induced by cues and priming. These effects appear to be specific to nicotine-associated behaviors, as stimulation did not have any effect on food-taking behavior. They appear to be anatomically specific, as stimulation surrounding the insular region had no effect on behavior. Stimulation of brain slices containing the insular region was found to inactivate insular neurons. Our results suggest that deep brain stimulation to modulate insular activity should be further explored.</p></div></front></TEI><pmc article-type="research-article"><pmc-comment>The publisher of this article does not allow downloading of the full text in XML form.</pmc-comment>
<front><journal-meta><journal-id journal-id-type="nlm-ta">Neuropsychopharmacology</journal-id><journal-id journal-id-type="iso-abbrev">Neuropsychopharmacology</journal-id><journal-title-group><journal-title>Neuropsychopharmacology</journal-title></journal-title-group><issn pub-type="ppub">0893-133X</issn><issn pub-type="epub">1740-634X</issn><publisher><publisher-name>Nature Publishing Group</publisher-name></publisher></journal-meta><article-meta><article-id pub-id-type="pmid">23249816</article-id><article-id pub-id-type="pmc">3572467</article-id><article-id pub-id-type="pii">npp2012235</article-id><article-id pub-id-type="doi">10.1038/npp.2012.235</article-id><article-categories><subj-group subj-group-type="heading"><subject>Original Article</subject></subj-group></article-categories><title-group><article-title>Electrical Stimulation of the Insular Region Attenuates Nicotine-Taking and Nicotine-Seeking Behaviors</article-title><alt-title alt-title-type="running">Electrical stimulation of insula on nicotine IVSA</alt-title></title-group><contrib-group><contrib contrib-type="author"><name><surname>Pushparaj</surname><given-names>Abhiram</given-names></name><xref ref-type="aff" rid="aff1">1</xref></contrib><contrib contrib-type="author"><name><surname>Hamani</surname><given-names>Clement</given-names></name><xref ref-type="aff" rid="aff2">2</xref><xref ref-type="aff" rid="aff3">3</xref></contrib><contrib contrib-type="author"><name><surname>Yu</surname><given-names>Wilson</given-names></name><xref ref-type="aff" rid="aff4">4</xref></contrib><contrib contrib-type="author"><name><surname>Shin</surname><given-names>Damian S</given-names></name><xref ref-type="aff" rid="aff4">4</xref></contrib><contrib contrib-type="author"><name><surname>Kang</surname><given-names>Bin</given-names></name><xref ref-type="aff" rid="aff1">1</xref></contrib><contrib contrib-type="author"><name><surname>Nobrega</surname><given-names>José N</given-names></name><xref ref-type="aff" rid="aff2">2</xref><xref ref-type="aff" rid="aff5">5</xref></contrib><contrib contrib-type="author"><name><surname>Le Foll</surname><given-names>Bernard</given-names></name><xref ref-type="aff" rid="aff1">1</xref><xref ref-type="aff" rid="aff6">6</xref><xref ref-type="aff" rid="aff7">7</xref><xref ref-type="corresp" rid="caf1">*</xref></contrib><aff id="aff1"><label>1</label><institution>Translational Addiction Research Laboratory, Campbell Family Mental Health Research Institute, Centre for Addiction and Mental Health (CAMH)</institution>, Toronto, ON,<country>Canada</country></aff><aff id="aff2"><label>2</label><institution>Research Imaging Centre, Campbell Family Mental Health Research Institute, Centre for Addiction and Mental Health</institution>, Toronto, ON,<country>Canada</country></aff><aff id="aff3"><label>3</label><institution>Division of Neurosurgery, Toronto Western Hospital</institution>, Toronto, ON,<country>Canada</country></aff><aff id="aff4"><label>4</label><institution>Center for Neuropharmacology and Neuroscience, Albany Medical College</institution>, Albany, NY,<country>USA</country></aff><aff id="aff5"><label>5</label><institution>Departments of Psychiatry, Pharmacology, Psychology, University of Toronto</institution>, Toronto, ON,<country>Canada</country></aff><aff id="aff6"><label>6</label><institution>Departments of Family and Community Medicine, Pharmacology, Psychiatry, Institute of Medical Sciences, University of Toronto</institution>, Toronto,<country>Canada</country></aff><aff id="aff7"><label>7</label><institution>Addiction Program, Centre for Addiction and Mental Health</institution>, Toronto, ON,<country>Canada</country></aff></contrib-group><author-notes><corresp id="caf1"><label>*</label><institution>Translational Addiction Research Laboratory, Campbell Family Mental Health Research Institute, Centre for Addiction and Mental Health (CAMH)</institution>, 33 Russell Street, Toronto, ON, <country>Canada</country> M5S 2S1, Tel: +416 535 8501; ext 4772, Fax: +416 595 6922, E-mail: <email>bernard_lefoll@camh.net</email></corresp></author-notes><pub-date pub-type="ppub"><month>03</month><year>2013</year></pub-date><pub-date pub-type="epreprint"><day>15</day><month>11</month><year>2012</year></pub-date><pub-date pub-type="epub"><day>19</day><month>12</month><year>2012</year></pub-date><volume>38</volume><issue>4</issue><fpage>690</fpage><lpage>698</lpage><history><date date-type="received"><day>25</day><month>09</month><year>2012</year></date><date date-type="rev-recd"><day>07</day><month>11</month><year>2012</year></date><date date-type="accepted"><day>08</day><month>11</month><year>2012</year></date></history><permissions><copyright-statement>Copyright © 2013 American College of Neuropsychopharmacology</copyright-statement><copyright-year>2013</copyright-year><copyright-holder>American College of Neuropsychopharmacology</copyright-holder></permissions><abstract><p>Pharmacological inactivation of the granular insular cortex is able to block nicotine-taking and -seeking behaviors in rats. In this study, we explored the potential of modulating activity in the insular region using electrical stimulation. Animals were trained to self-administer nicotine (0.03 mg/kg per infusion) under a fixed ratio-5 (FR-5) schedule of reinforcement followed by a progressive ratio (PR) schedule. Evaluation of the effect of stimulation in the insular region was performed on nicotine self-administration under FR-5 and PR schedules, as well on reinstatement of nicotine-seeking behavior induced by nicotine-associated cues or nicotine-priming injections. The effect of stimulation was also examined in brain slices containing insular neurons. Stimulation significantly attenuated nicotine-taking, under both schedules of reinforcement, as well as nicotine-seeking behavior induced by cues and priming. These effects appear to be specific to nicotine-associated behaviors, as stimulation did not have any effect on food-taking behavior. They appear to be anatomically specific, as stimulation surrounding the insular region had no effect on behavior. Stimulation of brain slices containing the insular region was found to inactivate insular neurons. Our results suggest that deep brain stimulation to modulate insular activity should be further explored.</p></abstract><kwd-group><kwd>insula</kwd><kwd>nicotine</kwd><kwd>self-administration</kwd><kwd>deep brain stimulation</kwd><kwd>rats</kwd><kwd>relapse</kwd></kwd-group><kwd-group kwd-group-type="author-keywords"><kwd>Addiction & Substance Abuse</kwd><kwd>Animal models</kwd><kwd>Behavioral Science</kwd><kwd>deep brain stimulation</kwd><kwd>Insula</kwd><kwd>Nicotine</kwd><kwd>Psychopharmacology</kwd><kwd>self-administration</kwd></kwd-group></article-meta></front></pmc></record>Pour manipuler ce document sous Unix (Dilib)
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