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Dysfunction of the Default Mode Network in Parkinson Disease

Identifieur interne : 000B27 ( Pmc/Checkpoint ); précédent : 000B26; suivant : 000B28

Dysfunction of the Default Mode Network in Parkinson Disease

Auteurs : Thilo Van Eimeren ; Oury Monchi ; Benedicte Ballanger ; Antonio P. Strafella

Source :

Archives of neurology [ 0003-9942 ] ; 2009.

RBID : PMC:2972248

Abstract

Objective

To examine the integrity of the default mode network in patients with Parkinson disease (PD). Previous functional neuroimaging experiments have studied executive deficits in patients with PD with regard to task-related brain activation. However, recent studies suggest that executive performance also relies on the integrity of the default mode network (ie, medial prefrontal cortex, posterior cingulate cortex, precuneus, and lateral parietal and medial temporal cortices), characterized by a deactivation of these cortical areas during the performance of executive tasks.

Design

We used functional magnetic resonance imaging to investigate cortical deactivations during a card-sorting task (retrieval and manipulation of short-term memory contents) compared with a simple sensory-motor matching task. In addition, a functional connectivity analysis was performed.

Setting

Tertiary outpatient clinic.

Participants

Seven patients with mild to moderate PD (not taking medication) and 7 healthy controls.

Main Outcome Measure

Cortical deactivations.

Results

Both groups showed comparable deactivation of the medial prefrontal cortex but different deactivation in the posterior cingulate cortex and the precuneus. Compared with controls, patients with PD not only showed less deactivation of the posterior cingulate cortex and the precuneus, they even demonstrated a reversed pattern of activation and deactivation. Connectivity analysis yielded that in contrast to healthy individuals, medial prefrontal cortex and the rostral ventromedial caudate nucleus were functionally disconnected in PD.

Conclusions

We describe specific malfunctioning of the default mode network during an executive task in PD. This finding is plausibly linked to dopamine depletion and may critically contribute to the understanding of executive deficits in PD.

Url:

http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2972248

DOI: 10.1001/archneurol.2009.97
PubMed: 19597090
PubMed Central: 2972248

Affiliations:

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PMC:2972248

Le document en format XML

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<author><name sortKey="Van Eimeren, Thilo" sort="Van Eimeren, Thilo" uniqKey="Van Eimeren T" first="Thilo" last="Van Eimeren">Thilo Van Eimeren</name>
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<author><name sortKey="Monchi, Oury" sort="Monchi, Oury" uniqKey="Monchi O" first="Oury" last="Monchi">Oury Monchi</name>
</author>
<author><name sortKey="Ballanger, Benedicte" sort="Ballanger, Benedicte" uniqKey="Ballanger B" first="Benedicte" last="Ballanger">Benedicte Ballanger</name>
</author>
<author><name sortKey="Strafella, Antonio P" sort="Strafella, Antonio P" uniqKey="Strafella A" first="Antonio P." last="Strafella">Antonio P. Strafella</name>
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<series><title level="j">Archives of neurology</title>
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<front><div type="abstract" xml:lang="en"><sec id="S1"><title>Objective</title>
<p id="P1">To examine the integrity of the default mode network in patients with Parkinson disease (PD). Previous functional neuroimaging experiments have studied executive deficits in patients with PD with regard to task-related brain activation. However, recent studies suggest that executive performance also relies on the integrity of the default mode network (ie, medial prefrontal cortex, posterior cingulate cortex, precuneus, and lateral parietal and medial temporal cortices), characterized by a deactivation of these cortical areas during the performance of executive tasks.</p>
</sec>
<sec id="S2"><title>Design</title>
<p id="P2">We used functional magnetic resonance imaging to investigate cortical deactivations during a card-sorting task (retrieval and manipulation of short-term memory contents) compared with a simple sensory-motor matching task. In addition, a functional connectivity analysis was performed.</p>
</sec>
<sec id="S3"><title>Setting</title>
<p id="P3">Tertiary outpatient clinic.</p>
</sec>
<sec id="S4"><title>Participants</title>
<p id="P4">Seven patients with mild to moderate PD (not taking medication) and 7 healthy controls.</p>
</sec>
<sec id="S5"><title>Main Outcome Measure</title>
<p id="P5">Cortical deactivations.</p>
</sec>
<sec id="S6"><title>Results</title>
<p id="P6">Both groups showed comparable deactivation of the medial prefrontal cortex but different deactivation in the posterior cingulate cortex and the precuneus. Compared with controls, patients with PD not only showed less deactivation of the posterior cingulate cortex and the precuneus, they even demonstrated a reversed pattern of activation and deactivation. Connectivity analysis yielded that in contrast to healthy individuals, medial prefrontal cortex and the rostral ventromedial caudate nucleus were functionally disconnected in PD.</p>
</sec>
<sec id="S7"><title>Conclusions</title>
<p id="P7">We describe specific malfunctioning of the default mode network during an executive task in PD. This finding is plausibly linked to dopamine depletion and may critically contribute to the understanding of executive deficits in PD.</p>
</sec>
</div>
</front>
</TEI>
<pmc article-type="research-article"><pmc-comment>The publisher of this article does not allow downloading of the full text in XML form.</pmc-comment>
  <pmc-dir>properties manuscript</pmc-dir>
  <front><journal-meta><journal-id journal-id-type="nlm-journal-id">0372436</journal-id>
<journal-id journal-id-type="pubmed-jr-id">804</journal-id>
<journal-id journal-id-type="nlm-ta">Arch Neurol</journal-id>
<journal-id journal-id-type="iso-abbrev">Arch. Neurol.</journal-id>
<journal-title-group><journal-title>Archives of neurology</journal-title>
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<issn pub-type="ppub">0003-9942</issn>
<issn pub-type="epub">1538-3687</issn>
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<article-meta><article-id pub-id-type="pmid">19597090</article-id>
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<article-id pub-id-type="doi">10.1001/archneurol.2009.97</article-id>
<article-id pub-id-type="manuscript">CAMS1533</article-id>
<article-categories><subj-group subj-group-type="heading"><subject>Article</subject>
</subj-group>
</article-categories>
<title-group><article-title>Dysfunction of the Default Mode Network in Parkinson Disease</article-title>
<subtitle>A Functional Magnetic Resonance Imaging Study</subtitle>
</title-group>
<contrib-group><contrib contrib-type="author"><name><surname>van Eimeren</surname>
<given-names>Thilo</given-names>
<prefix>Dr.</prefix>
</name>
<degrees>MD</degrees>
</contrib>
<contrib contrib-type="author"><name><surname>Monchi</surname>
<given-names>Oury</given-names>
<prefix>Dr.</prefix>
</name>
<degrees>PhD</degrees>
</contrib>
<contrib contrib-type="author"><name><surname>Ballanger</surname>
<given-names>Benedicte</given-names>
<prefix>Dr.</prefix>
</name>
<degrees>PhD</degrees>
</contrib>
<contrib contrib-type="author"><name><surname>Strafella</surname>
<given-names>Antonio P.</given-names>
<prefix>Dr.</prefix>
</name>
<degrees>MD, PhD, FRCPC</degrees>
</contrib>
<aff id="A1">Division of Brain, Imaging and Behaviour–Systems Neuroscience, Toronto Western Research Institute, and Movement Disorders Centre, Toronto Western Hospital, University Health Network (Drs van Eimeren, Ballanger, and Strafella), and PET Imaging Centre, Centre for Addiction and Mental Health (Drs van Eimeren, Ballanger, and Strafella), University of Toronto, Toronto, Ontario, and Centre de Recherche de l’Institut Universitaire de Gériatrie, Université de Montréal, Montréal, Québec (Dr Monchi), Canada</aff>
</contrib-group>
<author-notes><corresp id="FN1">Correspondence: Antonio P. Strafella, MD, PhD, FRCPC, Toronto Western Hospital/Institute and CAMH PET Centre, 250 College St, Toronto, ON M5T 1R8, Canada <email>antonio.strafella@uhnres.utoronto.ca</email>
</corresp>
</author-notes>
<pub-date pub-type="nihms-submitted"><day>26</day>
<month>10</month>
<year>2010</year>
</pub-date>
<pub-date pub-type="ppub"><month>7</month>
<year>2009</year>
</pub-date>
<pub-date pub-type="pmc-release"><day>03</day>
<month>11</month>
<year>2010</year>
</pub-date>
<volume>66</volume>
<issue>7</issue>
<fpage>877</fpage>
<lpage>883</lpage>
<abstract><sec id="S1"><title>Objective</title>
<p id="P1">To examine the integrity of the default mode network in patients with Parkinson disease (PD). Previous functional neuroimaging experiments have studied executive deficits in patients with PD with regard to task-related brain activation. However, recent studies suggest that executive performance also relies on the integrity of the default mode network (ie, medial prefrontal cortex, posterior cingulate cortex, precuneus, and lateral parietal and medial temporal cortices), characterized by a deactivation of these cortical areas during the performance of executive tasks.</p>
</sec>
<sec id="S2"><title>Design</title>
<p id="P2">We used functional magnetic resonance imaging to investigate cortical deactivations during a card-sorting task (retrieval and manipulation of short-term memory contents) compared with a simple sensory-motor matching task. In addition, a functional connectivity analysis was performed.</p>
</sec>
<sec id="S3"><title>Setting</title>
<p id="P3">Tertiary outpatient clinic.</p>
</sec>
<sec id="S4"><title>Participants</title>
<p id="P4">Seven patients with mild to moderate PD (not taking medication) and 7 healthy controls.</p>
</sec>
<sec id="S5"><title>Main Outcome Measure</title>
<p id="P5">Cortical deactivations.</p>
</sec>
<sec id="S6"><title>Results</title>
<p id="P6">Both groups showed comparable deactivation of the medial prefrontal cortex but different deactivation in the posterior cingulate cortex and the precuneus. Compared with controls, patients with PD not only showed less deactivation of the posterior cingulate cortex and the precuneus, they even demonstrated a reversed pattern of activation and deactivation. Connectivity analysis yielded that in contrast to healthy individuals, medial prefrontal cortex and the rostral ventromedial caudate nucleus were functionally disconnected in PD.</p>
</sec>
<sec id="S7"><title>Conclusions</title>
<p id="P7">We describe specific malfunctioning of the default mode network during an executive task in PD. This finding is plausibly linked to dopamine depletion and may critically contribute to the understanding of executive deficits in PD.</p>
</sec>
</abstract>
<funding-group><award-group><funding-source country="Canada">Canadian Institutes of Health Research : </funding-source>
<award-id>64423 || </award-id>
</award-group>
</funding-group>
</article-meta>
</front>
</pmc>
<affiliations><list></list>
<tree><noCountry><name sortKey="Ballanger, Benedicte" sort="Ballanger, Benedicte" uniqKey="Ballanger B" first="Benedicte" last="Ballanger">Benedicte Ballanger</name>
<name sortKey="Monchi, Oury" sort="Monchi, Oury" uniqKey="Monchi O" first="Oury" last="Monchi">Oury Monchi</name>
<name sortKey="Strafella, Antonio P" sort="Strafella, Antonio P" uniqKey="Strafella A" first="Antonio P." last="Strafella">Antonio P. Strafella</name>
<name sortKey="Van Eimeren, Thilo" sort="Van Eimeren, Thilo" uniqKey="Van Eimeren T" first="Thilo" last="Van Eimeren">Thilo Van Eimeren</name>
</noCountry>
</tree>
</affiliations>
</record>

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	La maladie de Parkinson au Canada (serveur d'exploration)
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La maladie de Parkinson au Canada (serveur d'exploration)

Dysfunction of the Default Mode Network in Parkinson Disease

Dysfunction of the Default Mode Network in Parkinson Disease

Source :

Abstract

Links toward previous steps (curation, corpus...)

Links to Exploration step

Le document en format XML

Pour manipuler ce document sous Unix (Dilib)

Pour mettre un lien sur cette page dans le réseau Wicri

Pour générer des pages wiki