Increased striatal dopamine release in Parkinsonian patients with pathological gambling: a [11C] raclopride PET study
Identifieur interne : 000B16 ( Pmc/Checkpoint ); précédent : 000B15; suivant : 000B17Increased striatal dopamine release in Parkinsonian patients with pathological gambling: a [11C] raclopride PET study
Auteurs : T. D. L. Steeves [Canada] ; J. Miyasaki [Canada] ; M. Zurowski [Canada] ; A. E. Lang [Canada] ; G. Pellecchia [Canada] ; T. Van Eimeren [Canada] ; P. Rusjan [Canada] ; S. Houle [Canada] ; A. P. Strafella [Canada]Source :
- Brain : a journal of neurology [ 0006-8950 ] ; 2009.
Abstract
Pathological gambling is an impulse control disorder reported in association with dopamine agonists used to treat Parkinson’s disease. Although impulse control disorders are conceptualized as lying within the spectrum of addictions, little neurobiological evidence exists to support this belief. Functional imaging studies have consistently demonstrated abnormalities of dopaminergic function in patients with drug addictions, but to date no study has specifically evaluated dopaminergic function in Parkinson’s disease patients with impulse control disorders. We describe results of a [11C] raclopride positron emission tomography (PET) study comparing dopaminergic function during gambling in Parkinson’s disease patients, with and without pathological gambling, following dopamine agonists. Patients with pathological gambling demonstrated greater decreases in binding potential in the ventral striatum during gambling (13.9%) than control patients (8.1%), likely reflecting greater dopaminergic release. Ventral striatal bindings at baseline during control task were also lower in patients with pathological gambling. Although prior imaging studies suggest that abnormality in dopaminergic binding and dopamine release may be markers of vulnerability to addiction, this study presents the first evidence of these phenomena in pathological gambling. The emergence of pathological gambling in a number of Parkinson’s disease patients may provide a model into the pathophysiology of this disorder.
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DOI: 10.1093/brain/awp054
PubMed: 19346328
PubMed Central: 3479148
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D. L." last="Steeves">T. D. L. Steeves</name><affiliation wicri:level="1"><nlm:aff id="A1">Movement Disorders Centre, Toronto Western Hospital, UHN, Ontario, Canada</nlm:aff><country xml:lang="fr">Canada</country><wicri:regionArea>Movement Disorders Centre, Toronto Western Hospital, UHN, Ontario</wicri:regionArea><wicri:noRegion>Ontario</wicri:noRegion></affiliation><affiliation wicri:level="1"><nlm:aff id="A2">PET Imaging Centre, Centre for Addiction and Mental Health, Ontario, Canada</nlm:aff><country xml:lang="fr">Canada</country><wicri:regionArea>PET Imaging Centre, Centre for Addiction and Mental Health, Ontario</wicri:regionArea><wicri:noRegion>Ontario</wicri:noRegion></affiliation></author><author><name sortKey="Miyasaki, J" sort="Miyasaki, J" uniqKey="Miyasaki J" first="J." last="Miyasaki">J. Miyasaki</name><affiliation wicri:level="1"><nlm:aff id="A1">Movement Disorders Centre, Toronto Western Hospital, UHN, Ontario, Canada</nlm:aff><country xml:lang="fr">Canada</country><wicri:regionArea>Movement Disorders Centre, Toronto Western Hospital, UHN, Ontario</wicri:regionArea><wicri:noRegion>Ontario</wicri:noRegion></affiliation></author><author><name sortKey="Zurowski, M" sort="Zurowski, M" uniqKey="Zurowski M" first="M." last="Zurowski">M. Zurowski</name><affiliation wicri:level="1"><nlm:aff id="A3">Psychiatry Department, Toronto Western Hospital, UHN, Ontario, Canada</nlm:aff><country xml:lang="fr">Canada</country><wicri:regionArea>Psychiatry Department, Toronto Western Hospital, UHN, Ontario</wicri:regionArea><wicri:noRegion>Ontario</wicri:noRegion></affiliation></author><author><name sortKey="Lang, A E" sort="Lang, A E" uniqKey="Lang A" first="A. E." last="Lang">A. E. Lang</name><affiliation wicri:level="1"><nlm:aff id="A1">Movement Disorders Centre, Toronto Western Hospital, UHN, Ontario, Canada</nlm:aff><country xml:lang="fr">Canada</country><wicri:regionArea>Movement Disorders Centre, Toronto Western Hospital, UHN, Ontario</wicri:regionArea><wicri:noRegion>Ontario</wicri:noRegion></affiliation></author><author><name sortKey="Pellecchia, G" sort="Pellecchia, G" uniqKey="Pellecchia G" first="G." last="Pellecchia">G. Pellecchia</name><affiliation wicri:level="1"><nlm:aff id="A2">PET Imaging Centre, Centre for Addiction and Mental Health, Ontario, Canada</nlm:aff><country xml:lang="fr">Canada</country><wicri:regionArea>PET Imaging Centre, Centre for Addiction and Mental Health, Ontario</wicri:regionArea><wicri:noRegion>Ontario</wicri:noRegion></affiliation></author><author><name sortKey="Van Eimeren, T" sort="Van Eimeren, T" uniqKey="Van Eimeren T" first="T." last="Van Eimeren">T. Van Eimeren</name><affiliation wicri:level="1"><nlm:aff id="A2">PET Imaging Centre, Centre for Addiction and Mental Health, Ontario, Canada</nlm:aff><country xml:lang="fr">Canada</country><wicri:regionArea>PET Imaging Centre, Centre for Addiction and Mental Health, Ontario</wicri:regionArea><wicri:noRegion>Ontario</wicri:noRegion></affiliation></author><author><name sortKey="Rusjan, P" sort="Rusjan, P" uniqKey="Rusjan P" first="P." last="Rusjan">P. Rusjan</name><affiliation wicri:level="1"><nlm:aff id="A2">PET Imaging Centre, Centre for Addiction and Mental Health, Ontario, Canada</nlm:aff><country xml:lang="fr">Canada</country><wicri:regionArea>PET Imaging Centre, Centre for Addiction and Mental Health, Ontario</wicri:regionArea><wicri:noRegion>Ontario</wicri:noRegion></affiliation></author><author><name sortKey="Houle, S" sort="Houle, S" uniqKey="Houle S" first="S." last="Houle">S. Houle</name><affiliation wicri:level="1"><nlm:aff id="A2">PET Imaging Centre, Centre for Addiction and Mental Health, Ontario, Canada</nlm:aff><country xml:lang="fr">Canada</country><wicri:regionArea>PET Imaging Centre, Centre for Addiction and Mental Health, Ontario</wicri:regionArea><wicri:noRegion>Ontario</wicri:noRegion></affiliation></author><author><name sortKey="Strafella, A P" sort="Strafella, A P" uniqKey="Strafella A" first="A. P." last="Strafella">A. P. Strafella</name><affiliation wicri:level="1"><nlm:aff id="A1">Movement Disorders Centre, Toronto Western Hospital, UHN, Ontario, Canada</nlm:aff><country xml:lang="fr">Canada</country><wicri:regionArea>Movement Disorders Centre, Toronto Western Hospital, UHN, Ontario</wicri:regionArea><wicri:noRegion>Ontario</wicri:noRegion></affiliation><affiliation wicri:level="1"><nlm:aff id="A2">PET Imaging Centre, Centre for Addiction and Mental Health, Ontario, Canada</nlm:aff><country xml:lang="fr">Canada</country><wicri:regionArea>PET Imaging Centre, Centre for Addiction and Mental Health, Ontario</wicri:regionArea><wicri:noRegion>Ontario</wicri:noRegion></affiliation><affiliation wicri:level="4"><nlm:aff id="A4">Division of Brain, Imaging and Behaviour – Systems Neuroscience, Toronto Western Research Institute, UHN, University of Toronto, Ontario, Canada</nlm:aff><country xml:lang="fr">Canada</country><wicri:regionArea>Division of Brain, Imaging and Behaviour – Systems Neuroscience, Toronto Western Research Institute, UHN, University of Toronto, Ontario</wicri:regionArea><orgName type="university">Université de Toronto</orgName><placeName><settlement type="city">Toronto</settlement><region type="state">Ontario</region></placeName></affiliation></author></analytic><series><title level="j">Brain : a journal of neurology</title><idno type="ISSN">0006-8950</idno><idno type="eISSN">1460-2156</idno><imprint><date when="2009">2009</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en"><p id="P1">Pathological gambling is an impulse control disorder reported in association with dopamine agonists used to treat Parkinson’s disease. Although impulse control disorders are conceptualized as lying within the spectrum of addictions, little neurobiological evidence exists to support this belief. Functional imaging studies have consistently demonstrated abnormalities of dopaminergic function in patients with drug addictions, but to date no study has specifically evaluated dopaminergic function in Parkinson’s disease patients with impulse control disorders. We describe results of a [<sup>11</sup>C] raclopride positron emission tomography (PET) study comparing dopaminergic function during gambling in Parkinson’s disease patients, with and without pathological gambling, following dopamine agonists. Patients with pathological gambling demonstrated greater decreases in binding potential in the ventral striatum during gambling (13.9%) than control patients (8.1%), likely reflecting greater dopaminergic release. Ventral striatal bindings at baseline during control task were also lower in patients with pathological gambling. Although prior imaging studies suggest that abnormality in dopaminergic binding and dopamine release may be markers of vulnerability to addiction, this study presents the first evidence of these phenomena in pathological gambling. The emergence of pathological gambling in a number of Parkinson’s disease patients may provide a model into the pathophysiology of this disorder.</p></div></front></TEI><pmc article-type="research-article"><pmc-comment>The publisher of this article does not allow downloading of the full text in XML form.</pmc-comment>
<pmc-dir>properties manuscript</pmc-dir>
<front><journal-meta><journal-id journal-id-type="nlm-journal-id">0372537</journal-id><journal-id journal-id-type="pubmed-jr-id">1917</journal-id><journal-id journal-id-type="nlm-ta">Brain</journal-id><journal-id journal-id-type="iso-abbrev">Brain</journal-id><journal-title-group><journal-title>Brain : a journal of neurology</journal-title></journal-title-group><issn pub-type="ppub">0006-8950</issn><issn pub-type="epub">1460-2156</issn></journal-meta><article-meta><article-id pub-id-type="pmid">19346328</article-id><article-id pub-id-type="pmc">3479148</article-id><article-id pub-id-type="doi">10.1093/brain/awp054</article-id><article-id pub-id-type="manuscript">CAMS2369</article-id><article-categories><subj-group subj-group-type="heading"><subject>Article</subject></subj-group></article-categories><title-group><article-title>Increased striatal dopamine release in Parkinsonian patients with pathological gambling: a [<sup>11</sup>C] raclopride PET study</article-title></title-group><contrib-group><contrib contrib-type="author"><name><surname>Steeves</surname><given-names>T. D. L.</given-names></name><xref ref-type="aff" rid="A1">1</xref><xref ref-type="aff" rid="A2">2</xref></contrib><contrib contrib-type="author"><name><surname>Miyasaki</surname><given-names>J.</given-names></name><xref ref-type="aff" rid="A1">1</xref></contrib><contrib contrib-type="author"><name><surname>Zurowski</surname><given-names>M.</given-names></name><xref ref-type="aff" rid="A3">3</xref></contrib><contrib contrib-type="author"><name><surname>Lang</surname><given-names>A. E.</given-names></name><xref ref-type="aff" rid="A1">1</xref></contrib><contrib contrib-type="author"><name><surname>Pellecchia</surname><given-names>G.</given-names></name><xref ref-type="aff" rid="A2">2</xref></contrib><contrib contrib-type="author"><name><surname>Van Eimeren</surname><given-names>T.</given-names></name><xref ref-type="aff" rid="A2">2</xref></contrib><contrib contrib-type="author"><name><surname>Rusjan</surname><given-names>P.</given-names></name><xref ref-type="aff" rid="A2">2</xref></contrib><contrib contrib-type="author"><name><surname>Houle</surname><given-names>S.</given-names></name><xref ref-type="aff" rid="A2">2</xref></contrib><contrib contrib-type="author"><name><surname>Strafella</surname><given-names>A. P.</given-names></name><xref ref-type="aff" rid="A1">1</xref><xref ref-type="aff" rid="A2">2</xref><xref ref-type="aff" rid="A4">4</xref></contrib></contrib-group><aff id="A1"><label>1</label>Movement Disorders Centre, Toronto Western Hospital, UHN, Ontario, Canada</aff><aff id="A2"><label>2</label>PET Imaging Centre, Centre for Addiction and Mental Health, Ontario, Canada</aff><aff id="A3"><label>3</label>Psychiatry Department, Toronto Western Hospital, UHN, Ontario, Canada</aff><aff id="A4"><label>4</label>Division of Brain, Imaging and Behaviour – Systems Neuroscience, Toronto Western Research Institute, UHN, University of Toronto, Ontario, Canada</aff><author-notes><corresp id="FN1">Correspondence to: Antonio P. Strafella, MD, PhD, FRCPC, Toronto Western Hospital/Institute & CAMH-PET Imaging Centre, University of Toronto, Toronto, ON, Canada, <email>antonio.strafella@uhnres.utoronto.ca</email> or <email>antonio.strafella@camhpet.ca</email></corresp></author-notes><pub-date pub-type="nihms-submitted"><day>7</day><month>9</month><year>2012</year></pub-date><pub-date pub-type="epub"><day>03</day><month>4</month><year>2009</year></pub-date><pub-date pub-type="ppub"><month>5</month><year>2009</year></pub-date><pub-date pub-type="pmc-release"><day>23</day><month>10</month><year>2012</year></pub-date><volume>132</volume><issue>Pt 5</issue><fpage>1376</fpage><lpage>1385</lpage><permissions><copyright-statement>© The Author (2009). Published by Oxford University Press on behalf of the Guarantors of Brain. All rights reserved.</copyright-statement><copyright-year>2009</copyright-year></permissions><abstract><p id="P1">Pathological gambling is an impulse control disorder reported in association with dopamine agonists used to treat Parkinson’s disease. Although impulse control disorders are conceptualized as lying within the spectrum of addictions, little neurobiological evidence exists to support this belief. Functional imaging studies have consistently demonstrated abnormalities of dopaminergic function in patients with drug addictions, but to date no study has specifically evaluated dopaminergic function in Parkinson’s disease patients with impulse control disorders. We describe results of a [<sup>11</sup>C] raclopride positron emission tomography (PET) study comparing dopaminergic function during gambling in Parkinson’s disease patients, with and without pathological gambling, following dopamine agonists. Patients with pathological gambling demonstrated greater decreases in binding potential in the ventral striatum during gambling (13.9%) than control patients (8.1%), likely reflecting greater dopaminergic release. Ventral striatal bindings at baseline during control task were also lower in patients with pathological gambling. Although prior imaging studies suggest that abnormality in dopaminergic binding and dopamine release may be markers of vulnerability to addiction, this study presents the first evidence of these phenomena in pathological gambling. The emergence of pathological gambling in a number of Parkinson’s disease patients may provide a model into the pathophysiology of this disorder.</p></abstract><kwd-group><kwd>Parkinson’s disease</kwd><kwd>dopamine</kwd><kwd>impulse control disorders</kwd><kwd>pathological gambling</kwd><kwd>PET</kwd><kwd>functional imaging</kwd></kwd-group><funding-group><award-group><funding-source country="Canada">Canadian Institutes of Health Research : </funding-source><award-id>64423 || </award-id></award-group></funding-group></article-meta></front></pmc><affiliations><list><country><li>Canada</li></country><region><li>Ontario</li></region><settlement><li>Toronto</li></settlement><orgName><li>Université de Toronto</li></orgName></list><tree><country name="Canada"><noRegion><name sortKey="Steeves, T D L" sort="Steeves, T D L" uniqKey="Steeves T" first="T. D. L." last="Steeves">T. D. L. Steeves</name></noRegion><name sortKey="Houle, S" sort="Houle, S" uniqKey="Houle S" first="S." last="Houle">S. Houle</name><name sortKey="Lang, A E" sort="Lang, A E" uniqKey="Lang A" first="A. E." last="Lang">A. E. Lang</name><name sortKey="Miyasaki, J" sort="Miyasaki, J" uniqKey="Miyasaki J" first="J." last="Miyasaki">J. Miyasaki</name><name sortKey="Pellecchia, G" sort="Pellecchia, G" uniqKey="Pellecchia G" first="G." last="Pellecchia">G. Pellecchia</name><name sortKey="Rusjan, P" sort="Rusjan, P" uniqKey="Rusjan P" first="P." last="Rusjan">P. Rusjan</name><name sortKey="Steeves, T D L" sort="Steeves, T D L" uniqKey="Steeves T" first="T. D. L." last="Steeves">T. D. L. Steeves</name><name sortKey="Strafella, A P" sort="Strafella, A P" uniqKey="Strafella A" first="A. P." last="Strafella">A. P. Strafella</name><name sortKey="Strafella, A P" sort="Strafella, A P" uniqKey="Strafella A" first="A. P." last="Strafella">A. P. Strafella</name><name sortKey="Strafella, A P" sort="Strafella, A P" uniqKey="Strafella A" first="A. P." last="Strafella">A. P. Strafella</name><name sortKey="Van Eimeren, T" sort="Van Eimeren, T" uniqKey="Van Eimeren T" first="T." last="Van Eimeren">T. Van Eimeren</name><name sortKey="Zurowski, M" sort="Zurowski, M" uniqKey="Zurowski M" first="M." last="Zurowski">M. Zurowski</name></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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