α-Synuclein Gene May Interact with Environmental Factors in Increasing Risk of Parkinson's Disease
Identifieur interne : 000A03 ( Pmc/Checkpoint ); précédent : 000A02; suivant : 000A04α-Synuclein Gene May Interact with Environmental Factors in Increasing Risk of Parkinson's Disease
Auteurs : Nicole M. Gatto [États-Unis] ; Shannon L. Rhodes [États-Unis] ; Angelika D. Manthripragada [États-Unis] ; Jeff Bronstein [États-Unis] ; Myles Cockburn [États-Unis] ; Matt Farrer [Canada] ; Beate Ritz [États-Unis]Source :
- Neuroepidemiology [ 0251-5350 ] ; 2010.
Abstract
Although of great interest and suggested in prior reports, possible α-synuclein
We used a population-based approach to examine whether the risk of Parkinson's disease (PD) depended on the combined presence of
Similar to recent meta- and pooled analyses, our data suggest a lower PD risk in subjects who were either homozygous or heterozygous for the
Url:
DOI: 10.1159/000315157
PubMed: 20664293
PubMed Central: 2945263
Affiliations:
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PMC:2945263Le document en format XML
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<author><name sortKey="Gatto, Nicole M" sort="Gatto, Nicole M" uniqKey="Gatto N" first="Nicole M." last="Gatto">Nicole M. Gatto</name>
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<author><name sortKey="Cockburn, Myles" sort="Cockburn, Myles" uniqKey="Cockburn M" first="Myles" last="Cockburn">Myles Cockburn</name>
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<author><name sortKey="Farrer, Matt" sort="Farrer, Matt" uniqKey="Farrer M" first="Matt" last="Farrer">Matt Farrer</name>
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<author><name sortKey="Ritz, Beate" sort="Ritz, Beate" uniqKey="Ritz B" first="Beate" last="Ritz">Beate Ritz</name>
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<affiliation wicri:level="1"><nlm:aff id="aff2">Department of Environmental Health Sciences, University of California Los Angeles, Calif., USA</nlm:aff>
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<affiliation wicri:level="1"><nlm:aff id="aff3">Department of Neurology, University of California Los Angeles, Calif., USA</nlm:aff>
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<wicri:regionArea>Department of Neurology, University of California Los Angeles, Calif.</wicri:regionArea>
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<sourceDesc><biblStruct><analytic><title xml:lang="en" level="a" type="main">α-Synuclein Gene May Interact with Environmental Factors in Increasing Risk of Parkinson's Disease</title>
<author><name sortKey="Gatto, Nicole M" sort="Gatto, Nicole M" uniqKey="Gatto N" first="Nicole M." last="Gatto">Nicole M. Gatto</name>
<affiliation wicri:level="1"><nlm:aff id="aff1">Department of Epidemiology, University of California Los Angeles, Calif., USA</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Department of Epidemiology, University of California Los Angeles, Calif.</wicri:regionArea>
<wicri:noRegion>Calif.</wicri:noRegion>
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<author><name sortKey="Rhodes, Shannon L" sort="Rhodes, Shannon L" uniqKey="Rhodes S" first="Shannon L." last="Rhodes">Shannon L. Rhodes</name>
<affiliation wicri:level="1"><nlm:aff id="aff1">Department of Epidemiology, University of California Los Angeles, Calif., USA</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Department of Epidemiology, University of California Los Angeles, Calif.</wicri:regionArea>
<wicri:noRegion>Calif.</wicri:noRegion>
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</author>
<author><name sortKey="Manthripragada, Angelika D" sort="Manthripragada, Angelika D" uniqKey="Manthripragada A" first="Angelika D." last="Manthripragada">Angelika D. Manthripragada</name>
<affiliation wicri:level="1"><nlm:aff id="aff1">Department of Epidemiology, University of California Los Angeles, Calif., USA</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Department of Epidemiology, University of California Los Angeles, Calif.</wicri:regionArea>
<wicri:noRegion>Calif.</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Bronstein, Jeff" sort="Bronstein, Jeff" uniqKey="Bronstein J" first="Jeff" last="Bronstein">Jeff Bronstein</name>
<affiliation wicri:level="1"><nlm:aff id="aff3">Department of Neurology, University of California Los Angeles, Calif., USA</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Department of Neurology, University of California Los Angeles, Calif.</wicri:regionArea>
<wicri:noRegion>Calif.</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Cockburn, Myles" sort="Cockburn, Myles" uniqKey="Cockburn M" first="Myles" last="Cockburn">Myles Cockburn</name>
<affiliation wicri:level="4"><nlm:aff id="aff4">Department of Preventive Medicine, University of Southern California, Los Angeles, Calif., USA</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Department of Preventive Medicine, University of Southern California, Los Angeles, Calif.</wicri:regionArea>
<orgName type="university">Université de Californie du Sud</orgName>
<placeName><settlement type="city">Los Angeles</settlement>
<region type="state">Californie</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Farrer, Matt" sort="Farrer, Matt" uniqKey="Farrer M" first="Matt" last="Farrer">Matt Farrer</name>
<affiliation wicri:level="1"><nlm:aff id="aff5">Department of Medical Genetics, University of British Columbia, Vancouver, B.C., Canada</nlm:aff>
<country xml:lang="fr">Canada</country>
<wicri:regionArea>Department of Medical Genetics, University of British Columbia, Vancouver, B.C.</wicri:regionArea>
<wicri:noRegion>B.C.</wicri:noRegion>
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</author>
<author><name sortKey="Ritz, Beate" sort="Ritz, Beate" uniqKey="Ritz B" first="Beate" last="Ritz">Beate Ritz</name>
<affiliation wicri:level="1"><nlm:aff id="aff1">Department of Epidemiology, University of California Los Angeles, Calif., USA</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Department of Epidemiology, University of California Los Angeles, Calif.</wicri:regionArea>
<wicri:noRegion>Calif.</wicri:noRegion>
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<affiliation wicri:level="1"><nlm:aff id="aff2">Department of Environmental Health Sciences, University of California Los Angeles, Calif., USA</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Department of Environmental Health Sciences, University of California Los Angeles, Calif.</wicri:regionArea>
<wicri:noRegion>Calif.</wicri:noRegion>
</affiliation>
<affiliation wicri:level="1"><nlm:aff id="aff3">Department of Neurology, University of California Los Angeles, Calif., USA</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Department of Neurology, University of California Los Angeles, Calif.</wicri:regionArea>
<wicri:noRegion>Calif.</wicri:noRegion>
</affiliation>
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</analytic>
<series><title level="j">Neuroepidemiology</title>
<idno type="ISSN">0251-5350</idno>
<idno type="eISSN">1423-0208</idno>
<imprint><date when="2010">2010</date>
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<front><div type="abstract" xml:lang="en"><sec><title>Background</title>
<p>Although of great interest and suggested in prior reports, possible α-synuclein <italic>(SNCA)</italic>
gene-environment interactions have not been well investigated in humans.</p>
</sec>
<sec><title>Methods</title>
<p>We used a population-based approach to examine whether the risk of Parkinson's disease (PD) depended on the combined presence of <italic>SNCA</italic>
variations and two important environmental factors, pesticide exposures and smoking.</p>
</sec>
<sec><title>Results/Conclusions</title>
<p>Similar to recent meta- and pooled analyses, our data suggest a lower PD risk in subjects who were either homozygous or heterozygous for the <italic>SNCA</italic>
REP1 259 genotype, and a higher risk in subjects who were either homozygous or heterozygous for the REP1 263 genotype, especially among subjects with an age of onset ≤68 years. More importantly, while analyses of interactions were limited by small cell sizes, risk due to <italic>SNCA</italic>
variations seemed to vary with pesticide exposure and smoking, especially in younger onset cases, suggesting an age-of-onset effect.</p>
</sec>
</div>
</front>
</TEI>
<pmc article-type="research-article"><pmc-comment>The publisher of this article does not allow downloading of the full text in XML form.</pmc-comment>
<front><journal-meta><journal-id journal-id-type="nlm-ta">Neuroepidemiology</journal-id>
<journal-id journal-id-type="iso-abbrev">Neuroepidemiology</journal-id>
<journal-id journal-id-type="publisher-id">NED</journal-id>
<journal-title-group><journal-title>Neuroepidemiology</journal-title>
</journal-title-group>
<issn pub-type="ppub">0251-5350</issn>
<issn pub-type="epub">1423-0208</issn>
<publisher><publisher-name>S. Karger AG</publisher-name>
<publisher-loc>Allschwilerstrasse 10, P.O. Box · Postfach · Case postale, CH–4009, Basel, Switzerland · Schweiz · Suisse, Phone: +41 61 306 11 11, Fax: +41 61 306 12 34, karger@karger.ch</publisher-loc>
</publisher>
</journal-meta>
<article-meta><article-id pub-id-type="pmid">20664293</article-id>
<article-id pub-id-type="pmc">2945263</article-id>
<article-id pub-id-type="doi">10.1159/000315157</article-id>
<article-id pub-id-type="publisher-id">ned0035-0191</article-id>
<article-categories><subj-group subj-group-type="heading"><subject>Original Paper</subject>
</subj-group>
</article-categories>
<title-group><article-title>α-Synuclein Gene May Interact with Environmental Factors in Increasing Risk of Parkinson's Disease</article-title>
</title-group>
<contrib-group><contrib contrib-type="author"><name><surname>Gatto</surname>
<given-names>Nicole M.</given-names>
</name>
<xref ref-type="aff" rid="aff1">a</xref>
</contrib>
<contrib contrib-type="author"><name><surname>Rhodes</surname>
<given-names>Shannon L.</given-names>
</name>
<xref ref-type="aff" rid="aff1">a</xref>
</contrib>
<contrib contrib-type="author"><name><surname>Manthripragada</surname>
<given-names>Angelika D.</given-names>
</name>
<xref ref-type="aff" rid="aff1">a</xref>
</contrib>
<contrib contrib-type="author"><name><surname>Bronstein</surname>
<given-names>Jeff</given-names>
</name>
<xref ref-type="aff" rid="aff3">c</xref>
</contrib>
<contrib contrib-type="author"><name><surname>Cockburn</surname>
<given-names>Myles</given-names>
</name>
<xref ref-type="aff" rid="aff4">d</xref>
</contrib>
<contrib contrib-type="author"><name><surname>Farrer</surname>
<given-names>Matt</given-names>
</name>
<xref ref-type="aff" rid="aff5">e</xref>
</contrib>
<contrib contrib-type="author"><name><surname>Ritz</surname>
<given-names>Beate</given-names>
</name>
<xref ref-type="aff" rid="aff1">a</xref>
<xref ref-type="aff" rid="aff2">b</xref>
<xref ref-type="aff" rid="aff3">c</xref>
<xref ref-type="corresp" rid="cor1">*</xref>
</contrib>
</contrib-group>
<aff id="aff1"><sup>a</sup>
Department of Epidemiology, University of California Los Angeles, Calif., USA</aff>
<aff id="aff2"><sup>b</sup>
Department of Environmental Health Sciences, University of California Los Angeles, Calif., USA</aff>
<aff id="aff3"><sup>c</sup>
Department of Neurology, University of California Los Angeles, Calif., USA</aff>
<aff id="aff4"><sup>d</sup>
Department of Preventive Medicine, University of Southern California, Los Angeles, Calif., USA</aff>
<aff id="aff5"><sup>e</sup>
Department of Medical Genetics, University of British Columbia, Vancouver, B.C., Canada</aff>
<author-notes><corresp id="cor1">*Prof. Beate Ritz, MD, PhD, Schools of Public Health and Medicine, UCLA, 650 Charles E. Young Drive, Box 951772, Los Angeles, CA 90095 1772 (USA), Tel. +1 310 206 7458, Fax +1 310 206 6039, E-Mail <email>britz@ucla.edu</email>
</corresp>
</author-notes>
<pub-date pub-type="ppub"><month>10</month>
<year>2010</year>
</pub-date>
<pub-date pub-type="epub"><day>24</day>
<month>7</month>
<year>2010</year>
</pub-date>
<pub-date pub-type="pmc-release"><day>1</day>
<month>10</month>
<year>2011</year>
</pub-date>
<pmc-comment> PMC Release delay is 12 months and 0 days and was based on the
. </pmc-comment>
<volume>35</volume>
<issue>3</issue>
<fpage>191</fpage>
<lpage>195</lpage>
<history><date date-type="received"><day>25</day>
<month>3</month>
<year>2010</year>
</date>
<date date-type="accepted"><day>11</day>
<month>5</month>
<year>2010</year>
</date>
</history>
<permissions><copyright-statement>Copyright © 2010 by S. Karger AG, Basel</copyright-statement>
<copyright-year>2010</copyright-year>
</permissions>
<abstract><sec><title>Background</title>
<p>Although of great interest and suggested in prior reports, possible α-synuclein <italic>(SNCA)</italic>
gene-environment interactions have not been well investigated in humans.</p>
</sec>
<sec><title>Methods</title>
<p>We used a population-based approach to examine whether the risk of Parkinson's disease (PD) depended on the combined presence of <italic>SNCA</italic>
variations and two important environmental factors, pesticide exposures and smoking.</p>
</sec>
<sec><title>Results/Conclusions</title>
<p>Similar to recent meta- and pooled analyses, our data suggest a lower PD risk in subjects who were either homozygous or heterozygous for the <italic>SNCA</italic>
REP1 259 genotype, and a higher risk in subjects who were either homozygous or heterozygous for the REP1 263 genotype, especially among subjects with an age of onset ≤68 years. More importantly, while analyses of interactions were limited by small cell sizes, risk due to <italic>SNCA</italic>
variations seemed to vary with pesticide exposure and smoking, especially in younger onset cases, suggesting an age-of-onset effect.</p>
</sec>
</abstract>
<kwd-group><title>Key Words</title>
<kwd>α-Synuclein</kwd>
<kwd>Pesticides</kwd>
<kwd>Parkinson's disease</kwd>
<kwd>Smoking</kwd>
<kwd>Age of onset</kwd>
<kwd>Paraquat</kwd>
<kwd>Interaction</kwd>
<kwd>REP1</kwd>
</kwd-group>
<counts><table-count count="2"></table-count>
<ref-count count="18"></ref-count>
<page-count count="5"></page-count>
</counts>
</article-meta>
</front>
</pmc>
<affiliations><list><country><li>Canada</li>
<li>États-Unis</li>
</country>
<region><li>Californie</li>
</region>
<settlement><li>Los Angeles</li>
</settlement>
<orgName><li>Université de Californie du Sud</li>
</orgName>
</list>
<tree><country name="États-Unis"><noRegion><name sortKey="Gatto, Nicole M" sort="Gatto, Nicole M" uniqKey="Gatto N" first="Nicole M." last="Gatto">Nicole M. Gatto</name>
</noRegion>
<name sortKey="Bronstein, Jeff" sort="Bronstein, Jeff" uniqKey="Bronstein J" first="Jeff" last="Bronstein">Jeff Bronstein</name>
<name sortKey="Cockburn, Myles" sort="Cockburn, Myles" uniqKey="Cockburn M" first="Myles" last="Cockburn">Myles Cockburn</name>
<name sortKey="Manthripragada, Angelika D" sort="Manthripragada, Angelika D" uniqKey="Manthripragada A" first="Angelika D." last="Manthripragada">Angelika D. Manthripragada</name>
<name sortKey="Rhodes, Shannon L" sort="Rhodes, Shannon L" uniqKey="Rhodes S" first="Shannon L." last="Rhodes">Shannon L. Rhodes</name>
<name sortKey="Ritz, Beate" sort="Ritz, Beate" uniqKey="Ritz B" first="Beate" last="Ritz">Beate Ritz</name>
<name sortKey="Ritz, Beate" sort="Ritz, Beate" uniqKey="Ritz B" first="Beate" last="Ritz">Beate Ritz</name>
<name sortKey="Ritz, Beate" sort="Ritz, Beate" uniqKey="Ritz B" first="Beate" last="Ritz">Beate Ritz</name>
</country>
<country name="Canada"><noRegion><name sortKey="Farrer, Matt" sort="Farrer, Matt" uniqKey="Farrer M" first="Matt" last="Farrer">Matt Farrer</name>
</noRegion>
</country>
</tree>
</affiliations>
</record>
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