A new MRI rating scale for progressive supranuclear palsy and multiple system atrophy: validity and reliability
Identifieur interne : 000991 ( Pmc/Checkpoint ); précédent : 000990; suivant : 000992A new MRI rating scale for progressive supranuclear palsy and multiple system atrophy: validity and reliability
Auteurs : Yan Rolland [France] ; Marc Vérin [France] ; Christine A. Payan [France] ; Simon Duchesne [Canada] ; Eduard Kraft [Allemagne] ; Till K. Hauser [Allemagne] ; Josef Jarosz [Royaume-Uni] ; Neil Deasy [Royaume-Uni] ; Luc Defevbre [France] ; Christine Delmaire [France] ; Didier Dormont [France] ; Albert C. Ludolph [Allemagne] ; Gilbert Bensimon [France] ; P Nigel Leigh [Royaume-Uni]Source :
- Journal of Neurology, Neurosurgery, and Psychiatry [ 0022-3050 ] ; 2011.
Abstract
To evaluate a standardised MRI acquisition protocol and a new image rating scale for disease severity in patients with progressive supranuclear palsy (PSP) and multiple systems atrophy (MSA) in a large multicentre study.
The MRI protocol consisted of two-dimensional sagittal and axial T1, axial PD, and axial and coronal T2 weighted acquisitions. The 32 item ordinal scale evaluated abnormalities within the basal ganglia and posterior fossa, blind to diagnosis. Among 760 patients in the study population (PSP=362, MSA=398), 627 had per protocol images (PSP=297, MSA=330). Intra-rater (n=60) and inter-rater (n=555) reliability were assessed through Cohen's statistic, and scale structure through principal component analysis (PCA) (n=441). Internal consistency and reliability were checked. Discriminant and predictive validity of extracted factors and total scores were tested for disease severity as per clinical diagnosis.
Intra-rater and inter-rater reliability were acceptable for 25 (78%) of the items scored (≥0.41). PCA revealed four meaningful clusters of covarying parameters (factor (F) F1: brainstem and cerebellum; F2: midbrain; F3: putamen; F4: other basal ganglia) with good to excellent internal consistency (Cronbach α 0.75–0.93) and moderate to excellent reliability (intraclass coefficient: F1: 0.92; F2: 0.79; F3: 0.71; F4: 0.49). The total score significantly discriminated for disease severity or diagnosis; factorial scores differentially discriminated for disease severity according to diagnosis (PSP: F1–F2; MSA: F2–F3). The total score was significantly related to survival in PSP (p<0.0007) or MSA (p<0.0005), indicating good predictive validity.
The scale is suitable for use in the context of multicentre studies and can reliably and consistently measure MRI abnormalities in PSP and MSA.
The study protocol was filed in the open clinical trial registry (
Url:
DOI: 10.1136/jnnp.2010.214890
PubMed: 21386111
PubMed Central: 3152869
Affiliations:
- Allemagne, Canada, France, Royaume-Uni
- Angleterre, Bade-Wurtemberg, District de Tübingen, Grand Londres, Région Bretagne, Île-de-France
- Londres, Paris, Rennes, Tübingen, Ulm
- Université d'Ulm
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Payan</name><affiliation wicri:level="3"><nlm:aff id="aff3">Département de Pharmacologie Clinique, Centre Hospitalo-Universitaire de la Pitié-Salpétrière, Assistance publique hôpitaux de Paris and UPMC Univ, Paris, France</nlm:aff><country xml:lang="fr">France</country><wicri:regionArea>Département de Pharmacologie Clinique, Centre Hospitalo-Universitaire de la Pitié-Salpétrière, Assistance publique hôpitaux de Paris and UPMC Univ, Paris</wicri:regionArea><placeName><region type="region">Île-de-France</region><region type="old region">Île-de-France</region><settlement type="city">Paris</settlement></placeName></affiliation></author><author><name sortKey="Duchesne, Simon" sort="Duchesne, Simon" uniqKey="Duchesne S" first="Simon" last="Duchesne">Simon Duchesne</name><affiliation wicri:level="1"><nlm:aff id="aff4">Department of Radiology and Robert Giffard Laval University Research Centre, Laval University, Quebec City, Canada</nlm:aff><country xml:lang="fr">Canada</country><wicri:regionArea>Department of Radiology and Robert Giffard Laval University Research Centre, Laval University, Quebec City</wicri:regionArea><wicri:noRegion>Quebec City</wicri:noRegion></affiliation></author><author><name sortKey="Kraft, Eduard" sort="Kraft, Eduard" uniqKey="Kraft E" first="Eduard" last="Kraft">Eduard Kraft</name><affiliation wicri:level="4"><nlm:aff id="aff5">Department of Neurology, University of Ulm, Baden-Wuerttemberg, Germany</nlm:aff><country xml:lang="fr">Allemagne</country><wicri:regionArea>Department of Neurology, University of Ulm, Baden-Wuerttemberg</wicri:regionArea><wicri:noRegion>Baden-Wuerttemberg</wicri:noRegion><orgName type="university">Université d'Ulm</orgName><placeName><settlement type="city">Ulm</settlement><region type="land" nuts="1">Bade-Wurtemberg</region><region type="district" nuts="2">District de Tübingen</region></placeName></affiliation></author><author><name sortKey="Hauser, Till K" sort="Hauser, Till K" uniqKey="Hauser T" first="Till K" last="Hauser">Till K. Hauser</name><affiliation wicri:level="3"><nlm:aff id="aff6">Department of Neuroradiology, University of Tübingen, Tübingen, Germany</nlm:aff><country xml:lang="fr">Allemagne</country><wicri:regionArea>Department of Neuroradiology, University of Tübingen, Tübingen</wicri:regionArea><placeName><region type="land" nuts="1">Bade-Wurtemberg</region><region type="district" nuts="2">District de Tübingen</region><settlement type="city">Tübingen</settlement></placeName></affiliation></author><author><name sortKey="Jarosz, Josef" sort="Jarosz, Josef" uniqKey="Jarosz J" first="Josef" last="Jarosz">Josef Jarosz</name><affiliation wicri:level="1"><nlm:aff id="aff7">Department of Neurology, Brighton and Sussex Medical School, Trafford Centre for Biomedical Research, University of Sussex Falmer, East Sussex, UK</nlm:aff><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>Department of Neurology, Brighton and Sussex Medical School, Trafford Centre for Biomedical Research, University of Sussex Falmer, East Sussex</wicri:regionArea><wicri:noRegion>East Sussex</wicri:noRegion></affiliation></author><author><name sortKey="Deasy, Neil" sort="Deasy, Neil" uniqKey="Deasy N" first="Neil" last="Deasy">Neil Deasy</name><affiliation wicri:level="3"><nlm:aff id="aff8">MRC Centre for Neurodegeneration Research, King's College London, Institute of Psychiatry, Department of Clinical Neuroscience, London, UK</nlm:aff><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>MRC Centre for Neurodegeneration Research, King's College London, Institute of Psychiatry, Department of Clinical Neuroscience, London</wicri:regionArea><placeName><settlement type="city">Londres</settlement><region type="country">Angleterre</region><region type="région" nuts="1">Grand Londres</region></placeName></affiliation></author><author><name sortKey="Defevbre, Luc" sort="Defevbre, Luc" uniqKey="Defevbre L" first="Luc" last="Defevbre">Luc Defevbre</name><affiliation wicri:level="1"><nlm:aff id="aff9">Department of Neurology Movement Disorders, Lille University, Salengro Hospital, Cedex Lille, France</nlm:aff><country xml:lang="fr">France</country><wicri:regionArea>Department of Neurology Movement Disorders, Lille University, Salengro Hospital, Cedex Lille</wicri:regionArea><wicri:noRegion>Cedex Lille</wicri:noRegion><wicri:noRegion>Cedex Lille</wicri:noRegion></affiliation></author><author><name sortKey="Delmaire, Christine" sort="Delmaire, Christine" uniqKey="Delmaire C" first="Christine" last="Delmaire">Christine Delmaire</name><affiliation wicri:level="1"><nlm:aff id="aff10">Department of Neuroradiology, Lille University, Salengro Hospital, Cedex Lille, France</nlm:aff><country xml:lang="fr">France</country><wicri:regionArea>Department of Neuroradiology, Lille University, Salengro Hospital, Cedex Lille</wicri:regionArea><wicri:noRegion>Cedex Lille</wicri:noRegion><wicri:noRegion>Cedex Lille</wicri:noRegion></affiliation></author><author><name sortKey="Dormont, Didier" sort="Dormont, Didier" uniqKey="Dormont D" first="Didier" last="Dormont">Didier Dormont</name><affiliation wicri:level="3"><nlm:aff id="aff11">Département de Neuroradiologie, Hôpital de la Pitié-Salpétrière, Assistance Publique Hôpitaux de Paris and UPMC Univ, Paris, France</nlm:aff><country xml:lang="fr">France</country><wicri:regionArea>Département de Neuroradiologie, Hôpital de la Pitié-Salpétrière, Assistance Publique Hôpitaux de Paris and UPMC Univ, Paris</wicri:regionArea><placeName><region type="region">Île-de-France</region><region type="old region">Île-de-France</region><settlement type="city">Paris</settlement></placeName></affiliation></author><author><name sortKey="Ludolph, Albert C" sort="Ludolph, Albert C" uniqKey="Ludolph A" first="Albert C" last="Ludolph">Albert C. Ludolph</name><affiliation wicri:level="4"><nlm:aff id="aff5">Department of Neurology, University of Ulm, Baden-Wuerttemberg, Germany</nlm:aff><country xml:lang="fr">Allemagne</country><wicri:regionArea>Department of Neurology, University of Ulm, Baden-Wuerttemberg</wicri:regionArea><wicri:noRegion>Baden-Wuerttemberg</wicri:noRegion><orgName type="university">Université d'Ulm</orgName><placeName><settlement type="city">Ulm</settlement><region type="land" nuts="1">Bade-Wurtemberg</region><region type="district" nuts="2">District de Tübingen</region></placeName></affiliation></author><author><name sortKey="Bensimon, Gilbert" sort="Bensimon, Gilbert" uniqKey="Bensimon G" first="Gilbert" last="Bensimon">Gilbert Bensimon</name><affiliation wicri:level="3"><nlm:aff id="aff3">Département de Pharmacologie Clinique, Centre Hospitalo-Universitaire de la Pitié-Salpétrière, Assistance publique hôpitaux de Paris and UPMC Univ, Paris, France</nlm:aff><country xml:lang="fr">France</country><wicri:regionArea>Département de Pharmacologie Clinique, Centre Hospitalo-Universitaire de la Pitié-Salpétrière, Assistance publique hôpitaux de Paris and UPMC Univ, Paris</wicri:regionArea><placeName><region type="region">Île-de-France</region><region type="old region">Île-de-France</region><settlement type="city">Paris</settlement></placeName></affiliation></author><author><name sortKey="Leigh, P Nigel" sort="Leigh, P Nigel" uniqKey="Leigh P" first="P Nigel" last="Leigh">P Nigel Leigh</name><affiliation wicri:level="1"><nlm:aff id="aff7">Department of Neurology, Brighton and Sussex Medical School, Trafford Centre for Biomedical Research, University of Sussex Falmer, East Sussex, UK</nlm:aff><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>Department of Neurology, Brighton and Sussex Medical School, Trafford Centre for Biomedical Research, University of Sussex Falmer, East Sussex</wicri:regionArea><wicri:noRegion>East Sussex</wicri:noRegion></affiliation></author></titleStmt><publicationStmt><idno type="wicri:source">PMC</idno><idno type="pmid">21386111</idno><idno type="pmc">3152869</idno><idno type="url">http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3152869</idno><idno type="RBID">PMC:3152869</idno><idno type="doi">10.1136/jnnp.2010.214890</idno><date when="2011">2011</date><idno type="wicri:Area/Pmc/Corpus">000A24</idno><idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Corpus" wicri:corpus="PMC">000A24</idno><idno type="wicri:Area/Pmc/Curation">000A24</idno><idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Curation">000A24</idno><idno type="wicri:Area/Pmc/Checkpoint">000991</idno><idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Checkpoint">000991</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en" level="a" type="main">A new MRI rating scale for progressive supranuclear palsy and multiple system atrophy: validity and reliability</title><author><name sortKey="Rolland, Yan" sort="Rolland, Yan" uniqKey="Rolland Y" first="Yan" last="Rolland">Yan Rolland</name><affiliation wicri:level="3"><nlm:aff id="aff1">Medical Imaging Department, Eugène Marquis Centre, Rennes, France</nlm:aff><country xml:lang="fr">France</country><wicri:regionArea>Medical Imaging Department, Eugène Marquis Centre, Rennes</wicri:regionArea><placeName><region type="region">Région Bretagne</region><region type="old region">Région Bretagne</region><settlement type="city">Rennes</settlement></placeName></affiliation></author><author><name sortKey="Verin, Marc" sort="Verin, Marc" uniqKey="Verin M" first="Marc" last="Vérin">Marc Vérin</name><affiliation wicri:level="3"><nlm:aff id="aff2">Department of Neurology, Pontchaillou University Hospital, Rennes, France</nlm:aff><country xml:lang="fr">France</country><wicri:regionArea>Department of Neurology, Pontchaillou University Hospital, Rennes</wicri:regionArea><placeName><region type="region">Région Bretagne</region><region type="old region">Région Bretagne</region><settlement type="city">Rennes</settlement></placeName></affiliation></author><author><name sortKey="Payan, Christine A" sort="Payan, Christine A" uniqKey="Payan C" first="Christine A" last="Payan">Christine A. Payan</name><affiliation wicri:level="3"><nlm:aff id="aff3">Département de Pharmacologie Clinique, Centre Hospitalo-Universitaire de la Pitié-Salpétrière, Assistance publique hôpitaux de Paris and UPMC Univ, Paris, France</nlm:aff><country xml:lang="fr">France</country><wicri:regionArea>Département de Pharmacologie Clinique, Centre Hospitalo-Universitaire de la Pitié-Salpétrière, Assistance publique hôpitaux de Paris and UPMC Univ, Paris</wicri:regionArea><placeName><region type="region">Île-de-France</region><region type="old region">Île-de-France</region><settlement type="city">Paris</settlement></placeName></affiliation></author><author><name sortKey="Duchesne, Simon" sort="Duchesne, Simon" uniqKey="Duchesne S" first="Simon" last="Duchesne">Simon Duchesne</name><affiliation wicri:level="1"><nlm:aff id="aff4">Department of Radiology and Robert Giffard Laval University Research Centre, Laval University, Quebec City, Canada</nlm:aff><country xml:lang="fr">Canada</country><wicri:regionArea>Department of Radiology and Robert Giffard Laval University Research Centre, Laval University, Quebec City</wicri:regionArea><wicri:noRegion>Quebec City</wicri:noRegion></affiliation></author><author><name sortKey="Kraft, Eduard" sort="Kraft, Eduard" uniqKey="Kraft E" first="Eduard" last="Kraft">Eduard Kraft</name><affiliation wicri:level="4"><nlm:aff id="aff5">Department of Neurology, University of Ulm, Baden-Wuerttemberg, Germany</nlm:aff><country xml:lang="fr">Allemagne</country><wicri:regionArea>Department of Neurology, University of Ulm, Baden-Wuerttemberg</wicri:regionArea><wicri:noRegion>Baden-Wuerttemberg</wicri:noRegion><orgName type="university">Université d'Ulm</orgName><placeName><settlement type="city">Ulm</settlement><region type="land" nuts="1">Bade-Wurtemberg</region><region type="district" nuts="2">District de Tübingen</region></placeName></affiliation></author><author><name sortKey="Hauser, Till K" sort="Hauser, Till K" uniqKey="Hauser T" first="Till K" last="Hauser">Till K. Hauser</name><affiliation wicri:level="3"><nlm:aff id="aff6">Department of Neuroradiology, University of Tübingen, Tübingen, Germany</nlm:aff><country xml:lang="fr">Allemagne</country><wicri:regionArea>Department of Neuroradiology, University of Tübingen, Tübingen</wicri:regionArea><placeName><region type="land" nuts="1">Bade-Wurtemberg</region><region type="district" nuts="2">District de Tübingen</region><settlement type="city">Tübingen</settlement></placeName></affiliation></author><author><name sortKey="Jarosz, Josef" sort="Jarosz, Josef" uniqKey="Jarosz J" first="Josef" last="Jarosz">Josef Jarosz</name><affiliation wicri:level="1"><nlm:aff id="aff7">Department of Neurology, Brighton and Sussex Medical School, Trafford Centre for Biomedical Research, University of Sussex Falmer, East Sussex, UK</nlm:aff><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>Department of Neurology, Brighton and Sussex Medical School, Trafford Centre for Biomedical Research, University of Sussex Falmer, East Sussex</wicri:regionArea><wicri:noRegion>East Sussex</wicri:noRegion></affiliation></author><author><name sortKey="Deasy, Neil" sort="Deasy, Neil" uniqKey="Deasy N" first="Neil" last="Deasy">Neil Deasy</name><affiliation wicri:level="3"><nlm:aff id="aff8">MRC Centre for Neurodegeneration Research, King's College London, Institute of Psychiatry, Department of Clinical Neuroscience, London, UK</nlm:aff><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>MRC Centre for Neurodegeneration Research, King's College London, Institute of Psychiatry, Department of Clinical Neuroscience, London</wicri:regionArea><placeName><settlement type="city">Londres</settlement><region type="country">Angleterre</region><region type="région" nuts="1">Grand Londres</region></placeName></affiliation></author><author><name sortKey="Defevbre, Luc" sort="Defevbre, Luc" uniqKey="Defevbre L" first="Luc" last="Defevbre">Luc Defevbre</name><affiliation wicri:level="1"><nlm:aff id="aff9">Department of Neurology Movement Disorders, Lille University, Salengro Hospital, Cedex Lille, France</nlm:aff><country xml:lang="fr">France</country><wicri:regionArea>Department of Neurology Movement Disorders, Lille University, Salengro Hospital, Cedex Lille</wicri:regionArea><wicri:noRegion>Cedex Lille</wicri:noRegion><wicri:noRegion>Cedex Lille</wicri:noRegion></affiliation></author><author><name sortKey="Delmaire, Christine" sort="Delmaire, Christine" uniqKey="Delmaire C" first="Christine" last="Delmaire">Christine Delmaire</name><affiliation wicri:level="1"><nlm:aff id="aff10">Department of Neuroradiology, Lille University, Salengro Hospital, Cedex Lille, France</nlm:aff><country xml:lang="fr">France</country><wicri:regionArea>Department of Neuroradiology, Lille University, Salengro Hospital, Cedex Lille</wicri:regionArea><wicri:noRegion>Cedex Lille</wicri:noRegion><wicri:noRegion>Cedex Lille</wicri:noRegion></affiliation></author><author><name sortKey="Dormont, Didier" sort="Dormont, Didier" uniqKey="Dormont D" first="Didier" last="Dormont">Didier Dormont</name><affiliation wicri:level="3"><nlm:aff id="aff11">Département de Neuroradiologie, Hôpital de la Pitié-Salpétrière, Assistance Publique Hôpitaux de Paris and UPMC Univ, Paris, France</nlm:aff><country xml:lang="fr">France</country><wicri:regionArea>Département de Neuroradiologie, Hôpital de la Pitié-Salpétrière, Assistance Publique Hôpitaux de Paris and UPMC Univ, Paris</wicri:regionArea><placeName><region type="region">Île-de-France</region><region type="old region">Île-de-France</region><settlement type="city">Paris</settlement></placeName></affiliation></author><author><name sortKey="Ludolph, Albert C" sort="Ludolph, Albert C" uniqKey="Ludolph A" first="Albert C" last="Ludolph">Albert C. Ludolph</name><affiliation wicri:level="4"><nlm:aff id="aff5">Department of Neurology, University of Ulm, Baden-Wuerttemberg, Germany</nlm:aff><country xml:lang="fr">Allemagne</country><wicri:regionArea>Department of Neurology, University of Ulm, Baden-Wuerttemberg</wicri:regionArea><wicri:noRegion>Baden-Wuerttemberg</wicri:noRegion><orgName type="university">Université d'Ulm</orgName><placeName><settlement type="city">Ulm</settlement><region type="land" nuts="1">Bade-Wurtemberg</region><region type="district" nuts="2">District de Tübingen</region></placeName></affiliation></author><author><name sortKey="Bensimon, Gilbert" sort="Bensimon, Gilbert" uniqKey="Bensimon G" first="Gilbert" last="Bensimon">Gilbert Bensimon</name><affiliation wicri:level="3"><nlm:aff id="aff3">Département de Pharmacologie Clinique, Centre Hospitalo-Universitaire de la Pitié-Salpétrière, Assistance publique hôpitaux de Paris and UPMC Univ, Paris, France</nlm:aff><country xml:lang="fr">France</country><wicri:regionArea>Département de Pharmacologie Clinique, Centre Hospitalo-Universitaire de la Pitié-Salpétrière, Assistance publique hôpitaux de Paris and UPMC Univ, Paris</wicri:regionArea><placeName><region type="region">Île-de-France</region><region type="old region">Île-de-France</region><settlement type="city">Paris</settlement></placeName></affiliation></author><author><name sortKey="Leigh, P Nigel" sort="Leigh, P Nigel" uniqKey="Leigh P" first="P Nigel" last="Leigh">P Nigel Leigh</name><affiliation wicri:level="1"><nlm:aff id="aff7">Department of Neurology, Brighton and Sussex Medical School, Trafford Centre for Biomedical Research, University of Sussex Falmer, East Sussex, UK</nlm:aff><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>Department of Neurology, Brighton and Sussex Medical School, Trafford Centre for Biomedical Research, University of Sussex Falmer, East Sussex</wicri:regionArea><wicri:noRegion>East Sussex</wicri:noRegion></affiliation></author></analytic><series><title level="j">Journal of Neurology, Neurosurgery, and Psychiatry</title><idno type="ISSN">0022-3050</idno><idno type="eISSN">1468-330X</idno><imprint><date when="2011">2011</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en"><sec><title>Aim</title><p>To evaluate a standardised MRI acquisition protocol and a new image rating scale for disease severity in patients with progressive supranuclear palsy (PSP) and multiple systems atrophy (MSA) in a large multicentre study.</p></sec><sec><title>Methods</title><p>The MRI protocol consisted of two-dimensional sagittal and axial T1, axial PD, and axial and coronal T2 weighted acquisitions. The 32 item ordinal scale evaluated abnormalities within the basal ganglia and posterior fossa, blind to diagnosis. Among 760 patients in the study population (PSP=362, MSA=398), 627 had per protocol images (PSP=297, MSA=330). Intra-rater (n=60) and inter-rater (n=555) reliability were assessed through Cohen's statistic, and scale structure through principal component analysis (PCA) (n=441). Internal consistency and reliability were checked. Discriminant and predictive validity of extracted factors and total scores were tested for disease severity as per clinical diagnosis.</p></sec><sec><title>Results</title><p>Intra-rater and inter-rater reliability were acceptable for 25 (78%) of the items scored (≥0.41). PCA revealed four meaningful clusters of covarying parameters (factor (F) F1: brainstem and cerebellum; F2: midbrain; F3: putamen; F4: other basal ganglia) with good to excellent internal consistency (Cronbach α 0.75–0.93) and moderate to excellent reliability (intraclass coefficient: F1: 0.92; F2: 0.79; F3: 0.71; F4: 0.49). The total score significantly discriminated for disease severity or diagnosis; factorial scores differentially discriminated for disease severity according to diagnosis (PSP: F1–F2; MSA: F2–F3). The total score was significantly related to survival in PSP (p<0.0007) or MSA (p<0.0005), indicating good predictive validity.</p></sec><sec><title>Conclusions</title><p>The scale is suitable for use in the context of multicentre studies and can reliably and consistently measure MRI abnormalities in PSP and MSA.</p></sec><sec><title>Clinical Trial Registration Number</title><p>The study protocol was filed in the open clinical trial registry (<ext-link ext-link-type="uri" xlink:href="http://www.clinicaltrials.gov">http://www.clinicaltrials.gov</ext-link>) with ID No NCT00211224.</p></sec></div></front><back><div1 type="bibliography"><listBibl><biblStruct><analytic><author><name sortKey="De Rijk, Mc" uniqKey="De Rijk M">MC de Rijk</name></author><author><name sortKey="Tzourio, C" uniqKey="Tzourio C">C Tzourio</name></author><author><name sortKey="Breteler, Mm" uniqKey="Breteler M">MM Breteler</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Schrag, A" 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<front><journal-meta><journal-id journal-id-type="nlm-ta">J Neurol Neurosurg Psychiatry</journal-id><journal-id journal-id-type="publisher-id">jnnp</journal-id><journal-id journal-id-type="hwp">jnnp</journal-id><journal-title-group><journal-title>Journal of Neurology, Neurosurgery, and Psychiatry</journal-title></journal-title-group><issn pub-type="ppub">0022-3050</issn><issn pub-type="epub">1468-330X</issn><publisher><publisher-name>BMJ Group</publisher-name><publisher-loc>BMA House, Tavistock Square, London, WC1H 9JR</publisher-loc></publisher></journal-meta><article-meta><article-id pub-id-type="pmid">21386111</article-id><article-id pub-id-type="pmc">3152869</article-id><article-id pub-id-type="publisher-id">jnnp214890</article-id><article-id pub-id-type="doi">10.1136/jnnp.2010.214890</article-id><article-categories><subj-group subj-group-type="heading"><subject>Research Paper</subject></subj-group><subj-group subj-group-type="hwp-journal-coll"><subject>1506</subject></subj-group></article-categories><title-group><article-title>A new MRI rating scale for progressive supranuclear palsy and multiple system atrophy: validity and reliability</article-title></title-group><contrib-group><contrib contrib-type="author"><name><surname>Rolland</surname><given-names>Yan</given-names></name><xref ref-type="aff" rid="aff1">1</xref></contrib><contrib contrib-type="author"><name><surname>Vérin</surname><given-names>Marc</given-names></name><xref ref-type="aff" rid="aff2">2</xref></contrib><contrib contrib-type="author"><name><surname>Payan</surname><given-names>Christine A</given-names></name><xref ref-type="aff" rid="aff3">3</xref></contrib><contrib contrib-type="author"><name><surname>Duchesne</surname><given-names>Simon</given-names></name><xref ref-type="aff" rid="aff4">4</xref></contrib><contrib contrib-type="author"><name><surname>Kraft</surname><given-names>Eduard</given-names></name><xref ref-type="aff" rid="aff5">5</xref></contrib><contrib contrib-type="author"><name><surname>Hauser</surname><given-names>Till K</given-names></name><xref ref-type="aff" rid="aff6">6</xref></contrib><contrib contrib-type="author"><name><surname>Jarosz</surname><given-names>Josef</given-names></name><xref ref-type="aff" rid="aff7">7</xref></contrib><contrib contrib-type="author"><name><surname>Deasy</surname><given-names>Neil</given-names></name><xref ref-type="aff" rid="aff8">8</xref></contrib><contrib contrib-type="author"><name><surname>Defevbre</surname><given-names>Luc</given-names></name><xref ref-type="aff" rid="aff9">9</xref></contrib><contrib contrib-type="author"><name><surname>Delmaire</surname><given-names>Christine</given-names></name><xref ref-type="aff" rid="aff10">10</xref></contrib><contrib contrib-type="author"><name><surname>Dormont</surname><given-names>Didier</given-names></name><xref ref-type="aff" rid="aff11">11</xref></contrib><contrib contrib-type="author"><name><surname>Ludolph</surname><given-names>Albert C</given-names></name><xref ref-type="aff" rid="aff5">5</xref></contrib><contrib contrib-type="author"><name><surname>Bensimon</surname><given-names>Gilbert</given-names></name><xref ref-type="aff" rid="aff3">3</xref></contrib><contrib contrib-type="author" corresp="yes"><name><surname>Leigh</surname><given-names>P Nigel</given-names></name><xref ref-type="aff" rid="aff7">7</xref></contrib><contrib contrib-type="author"><collab>on behalf of the NNIPPS Study Group</collab></contrib></contrib-group><aff id="aff1"><label>1</label>Medical Imaging Department, Eugène Marquis Centre, Rennes, France</aff><aff id="aff2"><label>2</label>Department of Neurology, Pontchaillou University Hospital, Rennes, France</aff><aff id="aff3"><label>3</label>Département de Pharmacologie Clinique, Centre Hospitalo-Universitaire de la Pitié-Salpétrière, Assistance publique hôpitaux de Paris and UPMC Univ, Paris, France</aff><aff id="aff4"><label>4</label>Department of Radiology and Robert Giffard Laval University Research Centre, Laval University, Quebec City, Canada</aff><aff id="aff5"><label>5</label>Department of Neurology, University of Ulm, Baden-Wuerttemberg, Germany</aff><aff id="aff6"><label>6</label>Department of Neuroradiology, University of Tübingen, Tübingen, Germany</aff><aff id="aff7"><label>7</label>Department of Neurology, Brighton and Sussex Medical School, Trafford Centre for Biomedical Research, University of Sussex Falmer, East Sussex, UK</aff><aff id="aff8"><label>8</label>MRC Centre for Neurodegeneration Research, King's College London, Institute of Psychiatry, Department of Clinical Neuroscience, London, UK</aff><aff id="aff9"><label>9</label>Department of Neurology Movement Disorders, Lille University, Salengro Hospital, Cedex Lille, France</aff><aff id="aff10"><label>10</label>Department of Neuroradiology, Lille University, Salengro Hospital, Cedex Lille, France</aff><aff id="aff11"><label>11</label>Département de Neuroradiologie, Hôpital de la Pitié-Salpétrière, Assistance Publique Hôpitaux de Paris and UPMC Univ, Paris, France</aff><author-notes><corresp><bold>Correspondence to</bold> Professor P N Leigh, Professor of Neurology, Brighton and Sussex Medical School, Trafford Centre for Biomedical Research University of Sussex, Falmer, East Sussex BN1 9RY; <email>bsms2899@bsms.ac.uk</email>or Dr Gilbert Bensimon, Département de Pharmacologie Clinique, Hôpital Pitié-Salpêtrière, 47 Bd de L'Hôpital, 75651 Paris Cedex 13, France; <email>gilbert.bensimon@psl.aphp.fr</email></corresp><fn fn-type="other"><p>GB and PNL contributed equally to this paper.</p></fn></author-notes><pub-date pub-type="epub"><day>8</day><month>3</month><year>2011</year></pub-date><pub-date pub-type="ppub"><month>9</month><year>2011</year></pub-date><pub-date pub-type="pmc-release"><day>8</day><month>3</month><year>2011</year></pub-date><pmc-comment> PMC Release delay is 0 months and 0 days and was based on the
<volume>82</volume><issue>9</issue><fpage>1025</fpage><lpage>1032</lpage><history><date date-type="received"><day>15</day><month>4</month><year>2010</year></date><date date-type="accepted"><day>6</day><month>1</month><year>2011</year></date></history><permissions><copyright-statement>© 2011, Published by the BMJ Publishing Group Limited. For permission to use (where not already granted under a licence) please go to http://group.bmj.com/group/rights-licensing/permissions.</copyright-statement><copyright-year>2011</copyright-year><license license-type="open-access"><license-p>This is an open-access article distributed under the terms of the Creative Commons Attribution Non-commercial License, which permits use, distribution, and reproduction in any medium, provided the original work is properly cited, the use is non commercial and is otherwise in compliance with the license. See: <ext-link ext-link-type="uri" xlink:href="http://creativecommons.org/licenses/by-nc/2.0/">http://creativecommons.org/licenses/by-nc/2.0/</ext-link> and <ext-link ext-link-type="uri" xlink:href="http://creativecommons.org/licenses/by-nc/2.0/legalcode">http://creativecommons.org/licenses/by-nc/2.0/legalcode</ext-link>.</license-p></license></permissions><self-uri xlink:title="pdf" xlink:type="simple" xlink:href="jnnp214890.pdf"></self-uri><abstract><sec><title>Aim</title><p>To evaluate a standardised MRI acquisition protocol and a new image rating scale for disease severity in patients with progressive supranuclear palsy (PSP) and multiple systems atrophy (MSA) in a large multicentre study.</p></sec><sec><title>Methods</title><p>The MRI protocol consisted of two-dimensional sagittal and axial T1, axial PD, and axial and coronal T2 weighted acquisitions. The 32 item ordinal scale evaluated abnormalities within the basal ganglia and posterior fossa, blind to diagnosis. Among 760 patients in the study population (PSP=362, MSA=398), 627 had per protocol images (PSP=297, MSA=330). Intra-rater (n=60) and inter-rater (n=555) reliability were assessed through Cohen's statistic, and scale structure through principal component analysis (PCA) (n=441). Internal consistency and reliability were checked. Discriminant and predictive validity of extracted factors and total scores were tested for disease severity as per clinical diagnosis.</p></sec><sec><title>Results</title><p>Intra-rater and inter-rater reliability were acceptable for 25 (78%) of the items scored (≥0.41). PCA revealed four meaningful clusters of covarying parameters (factor (F) F1: brainstem and cerebellum; F2: midbrain; F3: putamen; F4: other basal ganglia) with good to excellent internal consistency (Cronbach α 0.75–0.93) and moderate to excellent reliability (intraclass coefficient: F1: 0.92; F2: 0.79; F3: 0.71; F4: 0.49). The total score significantly discriminated for disease severity or diagnosis; factorial scores differentially discriminated for disease severity according to diagnosis (PSP: F1–F2; MSA: F2–F3). The total score was significantly related to survival in PSP (p<0.0007) or MSA (p<0.0005), indicating good predictive validity.</p></sec><sec><title>Conclusions</title><p>The scale is suitable for use in the context of multicentre studies and can reliably and consistently measure MRI abnormalities in PSP and MSA.</p></sec><sec><title>Clinical Trial Registration Number</title><p>The study protocol was filed in the open clinical trial registry (<ext-link ext-link-type="uri" xlink:href="http://www.clinicaltrials.gov">http://www.clinicaltrials.gov</ext-link>) with ID No NCT00211224.</p></sec></abstract></article-meta></front></pmc><affiliations><list><country><li>Allemagne</li><li>Canada</li><li>France</li><li>Royaume-Uni</li></country><region><li>Angleterre</li><li>Bade-Wurtemberg</li><li>District de Tübingen</li><li>Grand Londres</li><li>Région Bretagne</li><li>Île-de-France</li></region><settlement><li>Londres</li><li>Paris</li><li>Rennes</li><li>Tübingen</li><li>Ulm</li></settlement><orgName><li>Université d'Ulm</li></orgName></list><tree><country name="France"><region name="Région Bretagne"><name sortKey="Rolland, Yan" sort="Rolland, Yan" uniqKey="Rolland Y" first="Yan" last="Rolland">Yan Rolland</name></region><name sortKey="Bensimon, Gilbert" sort="Bensimon, Gilbert" uniqKey="Bensimon G" first="Gilbert" last="Bensimon">Gilbert Bensimon</name><name sortKey="Defevbre, Luc" sort="Defevbre, Luc" uniqKey="Defevbre L" first="Luc" last="Defevbre">Luc Defevbre</name><name sortKey="Delmaire, Christine" sort="Delmaire, Christine" uniqKey="Delmaire C" first="Christine" last="Delmaire">Christine Delmaire</name><name sortKey="Dormont, Didier" sort="Dormont, Didier" uniqKey="Dormont D" first="Didier" last="Dormont">Didier Dormont</name><name sortKey="Payan, Christine A" sort="Payan, Christine A" uniqKey="Payan C" first="Christine A" last="Payan">Christine A. Payan</name><name sortKey="Verin, Marc" sort="Verin, Marc" uniqKey="Verin M" first="Marc" last="Vérin">Marc Vérin</name></country><country name="Canada"><noRegion><name sortKey="Duchesne, Simon" sort="Duchesne, Simon" uniqKey="Duchesne S" first="Simon" last="Duchesne">Simon Duchesne</name></noRegion></country><country name="Allemagne"><region name="Bade-Wurtemberg"><name sortKey="Kraft, Eduard" sort="Kraft, Eduard" uniqKey="Kraft E" first="Eduard" last="Kraft">Eduard Kraft</name></region><name sortKey="Hauser, Till K" sort="Hauser, Till K" uniqKey="Hauser T" first="Till K" last="Hauser">Till K. Hauser</name><name sortKey="Ludolph, Albert C" sort="Ludolph, Albert C" uniqKey="Ludolph A" first="Albert C" last="Ludolph">Albert C. Ludolph</name></country><country name="Royaume-Uni"><noRegion><name sortKey="Jarosz, Josef" sort="Jarosz, Josef" uniqKey="Jarosz J" first="Josef" last="Jarosz">Josef Jarosz</name></noRegion><name sortKey="Deasy, Neil" sort="Deasy, Neil" uniqKey="Deasy N" first="Neil" last="Deasy">Neil Deasy</name><name sortKey="Leigh, P Nigel" sort="Leigh, P Nigel" uniqKey="Leigh P" first="P Nigel" last="Leigh">P Nigel Leigh</name></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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