Differential Response of Speed, Amplitude, and Rhythm to Dopaminergic Medications in Parkinson’s Disease
Identifieur interne : 000966 ( Pmc/Checkpoint ); précédent : 000965; suivant : 000967Differential Response of Speed, Amplitude, and Rhythm to Dopaminergic Medications in Parkinson’s Disease
Auteurs : Alberto J. Espay [États-Unis] ; Joe P. Giuffrida [États-Unis] ; Robert Chen [Canada] ; Megan Payne [États-Unis] ; Filomena Mazzella [Canada] ; Emily Dunn [États-Unis] ; Jennifer E. Vaughan [États-Unis] ; Andrew P. Duker [États-Unis] ; Alok Sahay [États-Unis] ; Sang Jin Kim [Canada] ; Fredy J. Revilla [États-Unis] ; Dustin A. Heldman [États-Unis]Source :
- Movement Disorders [ 0885-3185 ] ; 2011.
Abstract
Although movement impairment in Parkinson’s disease includes slowness (bradykinesia), decreased amplitude (hypokinesia), and dysrhythmia, clinicians are instructed to rate them in a combined 0–4 severity scale using the Unified Parkinson’s Disease Rating Scale motor subscale. The objective was to evaluate whether bradykinesia, hypokinesia, and dysrhythmia are associated with differential motor impairment and response to dopaminergic medications in patients with Parkinson’s disease. Eighty five Parkinson’s disease patients performed finger-tapping (item 23), hand-grasping (item 24), and pronation–supination (item 25) tasks OFF and ON medication while wearing motion sensors on the most affected hand. Speed, amplitude, and rhythm were rated using the Modified Bradykinesia Rating Scale. Quantitative variables representing speed (root mean square angular velocity), amplitude (excursion angle), and rhythm (coefficient of variation) were extracted from kinematic data. Fatigue was measured as decrements in speed and amplitude during the last 5 seconds compared with the first 5 seconds of movement. Amplitude impairments were worse and more prevalent than speed or rhythm impairments across all tasks (
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DOI: 10.1002/mds.23893
PubMed: 21953789
PubMed Central: 3318914
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Revilla</name><affiliation wicri:level="2"><nlm:aff id="A1">UC Neuroscience Institute, Department of Neurology, Gardner Center for Parkinson’s disease and Movement Disorders, University of Cincinnati, Cincinnati, Ohio, USA</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>UC Neuroscience Institute, Department of Neurology, Gardner Center for Parkinson’s disease and Movement Disorders, University of Cincinnati, Cincinnati, Ohio</wicri:regionArea><placeName><region type="state">Ohio</region></placeName></affiliation></author><author><name sortKey="Heldman, Dustin A" sort="Heldman, Dustin A" uniqKey="Heldman D" first="Dustin A." last="Heldman">Dustin A. 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Espay</name><affiliation wicri:level="2"><nlm:aff id="A1">UC Neuroscience Institute, Department of Neurology, Gardner Center for Parkinson’s disease and Movement Disorders, University of Cincinnati, Cincinnati, Ohio, USA</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>UC Neuroscience Institute, Department of Neurology, Gardner Center for Parkinson’s disease and Movement Disorders, University of Cincinnati, Cincinnati, Ohio</wicri:regionArea><placeName><region type="state">Ohio</region></placeName></affiliation></author><author><name sortKey="Giuffrida, Joe P" sort="Giuffrida, Joe P" uniqKey="Giuffrida J" first="Joe P." last="Giuffrida">Joe P. Giuffrida</name><affiliation wicri:level="2"><nlm:aff id="A2">Division of Movement Disorders, Great Lakes NeuroTechnologies Inc., Cleveland, Ohio, USA</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Division of Movement Disorders, Great Lakes NeuroTechnologies Inc., Cleveland, Ohio</wicri:regionArea><placeName><region type="state">Ohio</region></placeName></affiliation></author><author><name sortKey="Chen, Robert" sort="Chen, Robert" uniqKey="Chen R" first="Robert" last="Chen">Robert Chen</name><affiliation wicri:level="4"><nlm:aff id="A3">Toronto Western Research Institute and Division of Neurology, Department of Medicine, University of Toronto, Toronto, Ontario, Canada</nlm:aff><country xml:lang="fr">Canada</country><wicri:regionArea>Toronto Western Research Institute and Division of Neurology, Department of Medicine, University of Toronto, Toronto, Ontario</wicri:regionArea><orgName type="university">Université de Toronto</orgName><placeName><settlement type="city">Toronto</settlement><region type="state">Ontario</region></placeName></affiliation></author><author><name sortKey="Payne, Megan" sort="Payne, Megan" uniqKey="Payne M" first="Megan" last="Payne">Megan Payne</name><affiliation wicri:level="2"><nlm:aff id="A1">UC Neuroscience Institute, Department of Neurology, Gardner Center for Parkinson’s disease and Movement Disorders, University of Cincinnati, Cincinnati, Ohio, USA</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>UC Neuroscience Institute, Department of Neurology, Gardner Center for Parkinson’s disease and Movement Disorders, University of Cincinnati, Cincinnati, Ohio</wicri:regionArea><placeName><region type="state">Ohio</region></placeName></affiliation></author><author><name sortKey="Mazzella, Filomena" sort="Mazzella, Filomena" uniqKey="Mazzella F" first="Filomena" last="Mazzella">Filomena Mazzella</name><affiliation wicri:level="4"><nlm:aff id="A3">Toronto Western Research Institute and Division of Neurology, Department of Medicine, University of Toronto, Toronto, Ontario, Canada</nlm:aff><country xml:lang="fr">Canada</country><wicri:regionArea>Toronto Western Research Institute and Division of Neurology, Department of Medicine, University of Toronto, Toronto, Ontario</wicri:regionArea><orgName type="university">Université de Toronto</orgName><placeName><settlement type="city">Toronto</settlement><region type="state">Ontario</region></placeName></affiliation></author><author><name sortKey="Dunn, Emily" sort="Dunn, Emily" uniqKey="Dunn E" first="Emily" last="Dunn">Emily Dunn</name><affiliation wicri:level="2"><nlm:aff id="A1">UC Neuroscience Institute, Department of Neurology, Gardner Center for Parkinson’s disease and Movement Disorders, University of Cincinnati, Cincinnati, Ohio, USA</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>UC Neuroscience Institute, Department of Neurology, Gardner Center for Parkinson’s disease and Movement Disorders, University of Cincinnati, Cincinnati, Ohio</wicri:regionArea><placeName><region type="state">Ohio</region></placeName></affiliation></author><author><name sortKey="Vaughan, Jennifer E" sort="Vaughan, Jennifer E" uniqKey="Vaughan J" first="Jennifer E." last="Vaughan">Jennifer E. Vaughan</name><affiliation wicri:level="2"><nlm:aff id="A1">UC Neuroscience Institute, Department of Neurology, Gardner Center for Parkinson’s disease and Movement Disorders, University of Cincinnati, Cincinnati, Ohio, USA</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>UC Neuroscience Institute, Department of Neurology, Gardner Center for Parkinson’s disease and Movement Disorders, University of Cincinnati, Cincinnati, Ohio</wicri:regionArea><placeName><region type="state">Ohio</region></placeName></affiliation></author><author><name sortKey="Duker, Andrew P" sort="Duker, Andrew P" uniqKey="Duker A" first="Andrew P." last="Duker">Andrew P. Duker</name><affiliation wicri:level="2"><nlm:aff id="A1">UC Neuroscience Institute, Department of Neurology, Gardner Center for Parkinson’s disease and Movement Disorders, University of Cincinnati, Cincinnati, Ohio, USA</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>UC Neuroscience Institute, Department of Neurology, Gardner Center for Parkinson’s disease and Movement Disorders, University of Cincinnati, Cincinnati, Ohio</wicri:regionArea><placeName><region type="state">Ohio</region></placeName></affiliation></author><author><name sortKey="Sahay, Alok" sort="Sahay, Alok" uniqKey="Sahay A" first="Alok" last="Sahay">Alok Sahay</name><affiliation wicri:level="2"><nlm:aff id="A1">UC Neuroscience Institute, Department of Neurology, Gardner Center for Parkinson’s disease and Movement Disorders, University of Cincinnati, Cincinnati, Ohio, USA</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>UC Neuroscience Institute, Department of Neurology, Gardner Center for Parkinson’s disease and Movement Disorders, University of Cincinnati, Cincinnati, Ohio</wicri:regionArea><placeName><region type="state">Ohio</region></placeName></affiliation></author><author><name sortKey="Kim, Sang Jin" sort="Kim, Sang Jin" uniqKey="Kim S" first="Sang Jin" last="Kim">Sang Jin Kim</name><affiliation wicri:level="4"><nlm:aff id="A3">Toronto Western Research Institute and Division of Neurology, Department of Medicine, University of Toronto, Toronto, Ontario, Canada</nlm:aff><country xml:lang="fr">Canada</country><wicri:regionArea>Toronto Western Research Institute and Division of Neurology, Department of Medicine, University of Toronto, Toronto, Ontario</wicri:regionArea><orgName type="university">Université de Toronto</orgName><placeName><settlement type="city">Toronto</settlement><region type="state">Ontario</region></placeName></affiliation></author><author><name sortKey="Revilla, Fredy J" sort="Revilla, Fredy J" uniqKey="Revilla F" first="Fredy J." last="Revilla">Fredy J. Revilla</name><affiliation wicri:level="2"><nlm:aff id="A1">UC Neuroscience Institute, Department of Neurology, Gardner Center for Parkinson’s disease and Movement Disorders, University of Cincinnati, Cincinnati, Ohio, USA</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>UC Neuroscience Institute, Department of Neurology, Gardner Center for Parkinson’s disease and Movement Disorders, University of Cincinnati, Cincinnati, Ohio</wicri:regionArea><placeName><region type="state">Ohio</region></placeName></affiliation></author><author><name sortKey="Heldman, Dustin A" sort="Heldman, Dustin A" uniqKey="Heldman D" first="Dustin A." last="Heldman">Dustin A. Heldman</name><affiliation wicri:level="2"><nlm:aff id="A2">Division of Movement Disorders, Great Lakes NeuroTechnologies Inc., Cleveland, Ohio, USA</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Division of Movement Disorders, Great Lakes NeuroTechnologies Inc., Cleveland, Ohio</wicri:regionArea><placeName><region type="state">Ohio</region></placeName></affiliation></author></analytic><series><title level="j">Movement Disorders</title><idno type="ISSN">0885-3185</idno><idno type="eISSN">1531-8257</idno><imprint><date when="2011">2011</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en"><p id="P1">Although movement impairment in Parkinson’s disease includes slowness (bradykinesia), decreased amplitude (hypokinesia), and dysrhythmia, clinicians are instructed to rate them in a combined 0–4 severity scale using the Unified Parkinson’s Disease Rating Scale motor subscale. The objective was to evaluate whether bradykinesia, hypokinesia, and dysrhythmia are associated with differential motor impairment and response to dopaminergic medications in patients with Parkinson’s disease. Eighty five Parkinson’s disease patients performed finger-tapping (item 23), hand-grasping (item 24), and pronation–supination (item 25) tasks OFF and ON medication while wearing motion sensors on the most affected hand. Speed, amplitude, and rhythm were rated using the Modified Bradykinesia Rating Scale. Quantitative variables representing speed (root mean square angular velocity), amplitude (excursion angle), and rhythm (coefficient of variation) were extracted from kinematic data. Fatigue was measured as decrements in speed and amplitude during the last 5 seconds compared with the first 5 seconds of movement. Amplitude impairments were worse and more prevalent than speed or rhythm impairments across all tasks (<italic>P</italic> < .001); however, in the ON state, speed scores improved exclusively by clinical (<italic>P</italic> < 10<sup>−6</sup>) and predominantly by quantitative (<italic>P</italic> < .05) measures. Motor scores from OFF to ON improved in subjects who were strictly bradykinetic (<italic>P</italic> < .01) and both bradykinetic and hypokinetic (<italic>P</italic> < 10<sup>−6</sup>), but not in those strictly hypokinetic. Fatigue in speed and amplitude was not improved by medication. Hypokinesia is more prevalent than bradykinesia, but dopaminergic medications predominantly improve the latter. Parkinson’s disease patients may show different degrees of impairment in these movement components, which deserve separate measurement in research studies.</p></div></front></TEI><pmc article-type="research-article" xml:lang="en"><pmc-comment>The publisher of this article does not allow downloading of the full text in XML form.</pmc-comment>
<pmc-dir>properties manuscript</pmc-dir>
<front><journal-meta><journal-id journal-id-type="nlm-journal-id">8610688</journal-id><journal-id journal-id-type="pubmed-jr-id">5937</journal-id><journal-id journal-id-type="nlm-ta">Mov Disord</journal-id><journal-id journal-id-type="iso-abbrev">Mov. Disord.</journal-id><journal-title-group><journal-title>Movement Disorders</journal-title></journal-title-group><issn pub-type="ppub">0885-3185</issn><issn pub-type="epub">1531-8257</issn></journal-meta><article-meta><article-id pub-id-type="pmid">21953789</article-id><article-id pub-id-type="pmc">3318914</article-id><article-id pub-id-type="doi">10.1002/mds.23893</article-id><article-id pub-id-type="manuscript">NIHMS366465</article-id><article-categories><subj-group subj-group-type="heading"><subject>Article</subject></subj-group></article-categories><title-group><article-title>Differential Response of Speed, Amplitude, and Rhythm to Dopaminergic Medications in Parkinson’s Disease</article-title></title-group><contrib-group><contrib contrib-type="author"><name><surname>Espay</surname><given-names>Alberto J.</given-names></name><degrees>MD, MSc</degrees><xref ref-type="aff" rid="A1">1</xref><xref ref-type="corresp" rid="cor1">*</xref></contrib><contrib contrib-type="author"><name><surname>Giuffrida</surname><given-names>Joe P.</given-names></name><degrees>PhD</degrees><xref ref-type="aff" rid="A2">2</xref></contrib><contrib contrib-type="author"><name><surname>Chen</surname><given-names>Robert</given-names></name><degrees>MBBChir, MSc, FRCPC</degrees><xref ref-type="aff" rid="A3">3</xref></contrib><contrib contrib-type="author"><name><surname>Payne</surname><given-names>Megan</given-names></name><degrees>MS, MBA</degrees><xref ref-type="aff" rid="A1">1</xref></contrib><contrib contrib-type="author"><name><surname>Mazzella</surname><given-names>Filomena</given-names></name><degrees>BScN, RN</degrees><xref ref-type="aff" rid="A3">3</xref></contrib><contrib contrib-type="author"><name><surname>Dunn</surname><given-names>Emily</given-names></name><xref ref-type="aff" rid="A1">1</xref></contrib><contrib contrib-type="author"><name><surname>Vaughan</surname><given-names>Jennifer E.</given-names></name><degrees>BPhil</degrees><xref ref-type="aff" rid="A1">1</xref></contrib><contrib contrib-type="author"><name><surname>Duker</surname><given-names>Andrew P.</given-names></name><degrees>MD</degrees><xref ref-type="aff" rid="A1">1</xref></contrib><contrib contrib-type="author"><name><surname>Sahay</surname><given-names>Alok</given-names></name><degrees>MD</degrees><xref ref-type="aff" rid="A1">1</xref></contrib><contrib contrib-type="author"><name><surname>Kim</surname><given-names>Sang Jin</given-names></name><degrees>MD</degrees><xref ref-type="aff" rid="A3">3</xref></contrib><contrib contrib-type="author"><name><surname>Revilla</surname><given-names>Fredy J.</given-names></name><degrees>MD</degrees><xref ref-type="aff" rid="A1">1</xref></contrib><contrib contrib-type="author"><name><surname>Heldman</surname><given-names>Dustin A.</given-names></name><degrees>PhD</degrees><xref ref-type="aff" rid="A2">2</xref></contrib></contrib-group><aff id="A1"><label>1</label>UC Neuroscience Institute, Department of Neurology, Gardner Center for Parkinson’s disease and Movement Disorders, University of Cincinnati, Cincinnati, Ohio, USA</aff><aff id="A2"><label>2</label>Division of Movement Disorders, Great Lakes NeuroTechnologies Inc., Cleveland, Ohio, USA</aff><aff id="A3"><label>3</label>Toronto Western Research Institute and Division of Neurology, Department of Medicine, University of Toronto, Toronto, Ontario, Canada</aff><author-notes><corresp id="cor1"><label>*</label><bold>Correspondence to:</bold> Dr. Alberto J. Espay, Department of Neurology, University of Cincinnati, 260 Stetson St., Suite 2300 (PO Box 670525), Cincinnati, OH 45267-0525, USA; <email>alberto.espay@uc.edu</email></corresp></author-notes><pub-date pub-type="nihms-submitted"><day>27</day><month>3</month><year>2012</year></pub-date><pub-date pub-type="epub"><day>23</day><month>9</month><year>2011</year></pub-date><pub-date pub-type="ppub"><month>12</month><year>2011</year></pub-date><pub-date pub-type="pmc-release"><day>4</day><month>4</month><year>2012</year></pub-date><volume>26</volume><issue>14</issue><fpage>2504</fpage><lpage>2508</lpage><permissions><copyright-statement>© 2011 Movement Disorder Society</copyright-statement><copyright-year>2011</copyright-year></permissions><abstract><p id="P1">Although movement impairment in Parkinson’s disease includes slowness (bradykinesia), decreased amplitude (hypokinesia), and dysrhythmia, clinicians are instructed to rate them in a combined 0–4 severity scale using the Unified Parkinson’s Disease Rating Scale motor subscale. The objective was to evaluate whether bradykinesia, hypokinesia, and dysrhythmia are associated with differential motor impairment and response to dopaminergic medications in patients with Parkinson’s disease. Eighty five Parkinson’s disease patients performed finger-tapping (item 23), hand-grasping (item 24), and pronation–supination (item 25) tasks OFF and ON medication while wearing motion sensors on the most affected hand. Speed, amplitude, and rhythm were rated using the Modified Bradykinesia Rating Scale. Quantitative variables representing speed (root mean square angular velocity), amplitude (excursion angle), and rhythm (coefficient of variation) were extracted from kinematic data. Fatigue was measured as decrements in speed and amplitude during the last 5 seconds compared with the first 5 seconds of movement. Amplitude impairments were worse and more prevalent than speed or rhythm impairments across all tasks (<italic>P</italic> < .001); however, in the ON state, speed scores improved exclusively by clinical (<italic>P</italic> < 10<sup>−6</sup>) and predominantly by quantitative (<italic>P</italic> < .05) measures. Motor scores from OFF to ON improved in subjects who were strictly bradykinetic (<italic>P</italic> < .01) and both bradykinetic and hypokinetic (<italic>P</italic> < 10<sup>−6</sup>), but not in those strictly hypokinetic. Fatigue in speed and amplitude was not improved by medication. Hypokinesia is more prevalent than bradykinesia, but dopaminergic medications predominantly improve the latter. Parkinson’s disease patients may show different degrees of impairment in these movement components, which deserve separate measurement in research studies.</p></abstract><kwd-group><kwd>Parkinson’s disease</kwd><kwd>bradykinesia</kwd><kwd>UPDRS</kwd><kwd>MBRS</kwd><kwd>KinetiSense</kwd></kwd-group></article-meta></front></pmc><affiliations><list><country><li>Canada</li><li>États-Unis</li></country><region><li>Ohio</li><li>Ontario</li></region><settlement><li>Toronto</li></settlement><orgName><li>Université de Toronto</li></orgName></list><tree><country name="États-Unis"><region name="Ohio"><name sortKey="Espay, Alberto J" sort="Espay, Alberto J" uniqKey="Espay A" first="Alberto J." last="Espay">Alberto J. Espay</name></region><name sortKey="Duker, Andrew P" sort="Duker, Andrew P" uniqKey="Duker A" first="Andrew P." last="Duker">Andrew P. Duker</name><name sortKey="Dunn, Emily" sort="Dunn, Emily" uniqKey="Dunn E" first="Emily" last="Dunn">Emily Dunn</name><name sortKey="Giuffrida, Joe P" sort="Giuffrida, Joe P" uniqKey="Giuffrida J" first="Joe P." last="Giuffrida">Joe P. Giuffrida</name><name sortKey="Heldman, Dustin A" sort="Heldman, Dustin A" uniqKey="Heldman D" first="Dustin A." last="Heldman">Dustin A. Heldman</name><name sortKey="Payne, Megan" sort="Payne, Megan" uniqKey="Payne M" first="Megan" last="Payne">Megan Payne</name><name sortKey="Revilla, Fredy J" sort="Revilla, Fredy J" uniqKey="Revilla F" first="Fredy J." last="Revilla">Fredy J. Revilla</name><name sortKey="Sahay, Alok" sort="Sahay, Alok" uniqKey="Sahay A" first="Alok" last="Sahay">Alok Sahay</name><name sortKey="Vaughan, Jennifer E" sort="Vaughan, Jennifer E" uniqKey="Vaughan J" first="Jennifer E." last="Vaughan">Jennifer E. Vaughan</name></country><country name="Canada"><region name="Ontario"><name sortKey="Chen, Robert" sort="Chen, Robert" uniqKey="Chen R" first="Robert" last="Chen">Robert Chen</name></region><name sortKey="Kim, Sang Jin" sort="Kim, Sang Jin" uniqKey="Kim S" first="Sang Jin" last="Kim">Sang Jin Kim</name><name sortKey="Mazzella, Filomena" sort="Mazzella, Filomena" uniqKey="Mazzella F" first="Filomena" last="Mazzella">Filomena Mazzella</name></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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