Essential tremor is not a neurodegenerative disease
Identifieur interne : 000834 ( Pmc/Checkpoint ); précédent : 000833; suivant : 000835Essential tremor is not a neurodegenerative disease
Auteurs : Ali H. Rajput [Canada] ; Charles H. Adler [États-Unis] ; Holly A. Shill [États-Unis] ; Alex Rajput [Canada]Source :
- Neurodegenerative disease management [ 1758-2024 ] ; 2012.
Abstract
The pathophysiology of essential tremor (ET) remains unknown. Standard neuropathological studies have reported no consistent changes but a detailed study found neurodegeneration in all ET cases – 24% demonstrated lower brainstem Lewy body (LB) inclusions and 76% experienced a loss of cerebellar Purkinje cells (PCs) and its sequelae. We review the evidence on neurodegeneration in ET. The prevalence of LB inclusions in ET brains is similar to that in the asymptomatic general population. These incidental LB disease cases have evidence for reduced striatal tyrosine hydroxylase levels, as found in Parkinson’s disease, but there is no evidence for reduced tyrosine hydroxylase levels in ET patients. Reduced mean PC counts in ET cases compared with the controls reported by some studies could not be replicated by others. Most ET cases have the same number of PCs as controls of a comparable age. Neither the lower brainstem LB inclusions nor the cerebellar PC loss represent the neurodegenerative basis of ET. Further studies are needed to determine the pathophysiology of ET.
Url:
DOI: 10.2217/nmt.12.23
PubMed: 23105950
PubMed Central: 3478956
Affiliations:
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Adler</name><affiliation wicri:level="1"><nlm:aff id="A2">Parkinson’s Disease & Movement Disorders Center, Mayo Clinic Scottsdale, 13400 East Shea Boulevard, Scottsdale, AZ 85259, USA</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Parkinson’s Disease & Movement Disorders Center, Mayo Clinic Scottsdale, 13400 East Shea Boulevard, Scottsdale, AZ 85259</wicri:regionArea><wicri:noRegion>AZ 85259</wicri:noRegion></affiliation></author><author><name sortKey="Shill, Holly A" sort="Shill, Holly A" uniqKey="Shill H" first="Holly A" last="Shill">Holly A. Shill</name><affiliation wicri:level="1"><nlm:aff id="A3">Banner Sun Health Research Institute, 10515 W. Santa Fe Drive, Sun City, AZ 85351, USA</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Banner Sun Health Research Institute, 10515 W. 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Rajput</name><affiliation wicri:level="1"><nlm:aff id="A1">Movement Disorders Program, Neurology Division, University of Saskatchewan/Saskatoon Health Region, 103 Hospital Drive, Saskatoon, SK, S7N 0W8, Canada</nlm:aff><country xml:lang="fr">Canada</country><wicri:regionArea>Movement Disorders Program, Neurology Division, University of Saskatchewan/Saskatoon Health Region, 103 Hospital Drive, Saskatoon, SK, S7N 0W8</wicri:regionArea><wicri:noRegion>S7N 0W8</wicri:noRegion></affiliation></author><author><name sortKey="Adler, Charles H" sort="Adler, Charles H" uniqKey="Adler C" first="Charles H" last="Adler">Charles H. Adler</name><affiliation wicri:level="1"><nlm:aff id="A2">Parkinson’s Disease & Movement Disorders Center, Mayo Clinic Scottsdale, 13400 East Shea Boulevard, Scottsdale, AZ 85259, USA</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Parkinson’s Disease & Movement Disorders Center, Mayo Clinic Scottsdale, 13400 East Shea Boulevard, Scottsdale, AZ 85259</wicri:regionArea><wicri:noRegion>AZ 85259</wicri:noRegion></affiliation></author><author><name sortKey="Shill, Holly A" sort="Shill, Holly A" uniqKey="Shill H" first="Holly A" last="Shill">Holly A. Shill</name><affiliation wicri:level="1"><nlm:aff id="A3">Banner Sun Health Research Institute, 10515 W. Santa Fe Drive, Sun City, AZ 85351, USA</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Banner Sun Health Research Institute, 10515 W. Santa Fe Drive, Sun City, AZ 85351</wicri:regionArea><wicri:noRegion>AZ 85351</wicri:noRegion></affiliation></author><author><name sortKey="Rajput, Alex" sort="Rajput, Alex" uniqKey="Rajput A" first="Alex" last="Rajput">Alex Rajput</name><affiliation wicri:level="1"><nlm:aff id="A1">Movement Disorders Program, Neurology Division, University of Saskatchewan/Saskatoon Health Region, 103 Hospital Drive, Saskatoon, SK, S7N 0W8, Canada</nlm:aff><country xml:lang="fr">Canada</country><wicri:regionArea>Movement Disorders Program, Neurology Division, University of Saskatchewan/Saskatoon Health Region, 103 Hospital Drive, Saskatoon, SK, S7N 0W8</wicri:regionArea><wicri:noRegion>S7N 0W8</wicri:noRegion></affiliation></author></analytic><series><title level="j">Neurodegenerative disease management</title><idno type="ISSN">1758-2024</idno><idno type="eISSN">1758-2032</idno><imprint><date when="2012">2012</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en"><title>SUMMARY</title><p id="P1">The pathophysiology of essential tremor (ET) remains unknown. Standard neuropathological studies have reported no consistent changes but a detailed study found neurodegeneration in all ET cases – 24% demonstrated lower brainstem Lewy body (LB) inclusions and 76% experienced a loss of cerebellar Purkinje cells (PCs) and its sequelae. We review the evidence on neurodegeneration in ET. The prevalence of LB inclusions in ET brains is similar to that in the asymptomatic general population. These incidental LB disease cases have evidence for reduced striatal tyrosine hydroxylase levels, as found in Parkinson’s disease, but there is no evidence for reduced tyrosine hydroxylase levels in ET patients. Reduced mean PC counts in ET cases compared with the controls reported by some studies could not be replicated by others. Most ET cases have the same number of PCs as controls of a comparable age. Neither the lower brainstem LB inclusions nor the cerebellar PC loss represent the neurodegenerative basis of ET. Further studies are needed to determine the pathophysiology of ET.</p></div></front></TEI><pmc article-type="research-article"><pmc-comment>The publisher of this article does not allow downloading of the full text in XML form.</pmc-comment>
<pmc-dir>properties manuscript</pmc-dir>
<front><journal-meta><journal-id journal-id-type="nlm-journal-id">101517977</journal-id><journal-id journal-id-type="pubmed-jr-id">39348</journal-id><journal-id journal-id-type="nlm-ta">Neurodegener Dis Manag</journal-id><journal-id journal-id-type="iso-abbrev">Neurodegener Dis Manag</journal-id><journal-title-group><journal-title>Neurodegenerative disease management</journal-title></journal-title-group><issn pub-type="ppub">1758-2024</issn><issn pub-type="epub">1758-2032</issn></journal-meta><article-meta><article-id pub-id-type="pmid">23105950</article-id><article-id pub-id-type="pmc">3478956</article-id><article-id pub-id-type="doi">10.2217/nmt.12.23</article-id><article-id pub-id-type="manuscript">NIHMS405996</article-id><article-categories><subj-group subj-group-type="heading"><subject>Article</subject></subj-group></article-categories><title-group><article-title>Essential tremor is not a neurodegenerative disease</article-title></title-group><contrib-group><contrib contrib-type="author"><name><surname>Rajput</surname><given-names>Ali H</given-names></name><xref ref-type="aff" rid="A1">1</xref><xref rid="FN1" ref-type="author-notes">*</xref></contrib><contrib contrib-type="author"><name><surname>Adler</surname><given-names>Charles H</given-names></name><xref ref-type="aff" rid="A2">2</xref></contrib><contrib contrib-type="author"><name><surname>Shill</surname><given-names>Holly A</given-names></name><xref ref-type="aff" rid="A3">3</xref></contrib><contrib contrib-type="author"><name><surname>Rajput</surname><given-names>Alex</given-names></name><xref ref-type="aff" rid="A1">1</xref></contrib></contrib-group><aff id="A1"><label>1</label>Movement Disorders Program, Neurology Division, University of Saskatchewan/Saskatoon Health Region, 103 Hospital Drive, Saskatoon, SK, S7N 0W8, Canada</aff><aff id="A2"><label>2</label>Parkinson’s Disease & Movement Disorders Center, Mayo Clinic Scottsdale, 13400 East Shea Boulevard, Scottsdale, AZ 85259, USA</aff><aff id="A3"><label>3</label>Banner Sun Health Research Institute, 10515 W. Santa Fe Drive, Sun City, AZ 85351, USA</aff><author-notes><corresp id="FN1"><label>*</label>Author for correspondence: Tel.: +1 306 966 8009; Fax: +1 306 966 8030; <email>ali.rajput@saskatoonhealthregion.ca</email></corresp></author-notes><pub-date pub-type="nihms-submitted"><day>29</day><month>9</month><year>2012</year></pub-date><pub-date pub-type="ppub"><month>6</month><year>2012</year></pub-date><pub-date pub-type="pmc-release"><day>01</day><month>4</month><year>2013</year></pub-date><volume>2</volume><issue>3</issue><fpage>259</fpage><lpage>268</lpage><permissions><copyright-statement>© 2012 Future Medicine Ltd</copyright-statement><copyright-year>2012</copyright-year></permissions><abstract><title>SUMMARY</title><p id="P1">The pathophysiology of essential tremor (ET) remains unknown. Standard neuropathological studies have reported no consistent changes but a detailed study found neurodegeneration in all ET cases – 24% demonstrated lower brainstem Lewy body (LB) inclusions and 76% experienced a loss of cerebellar Purkinje cells (PCs) and its sequelae. We review the evidence on neurodegeneration in ET. The prevalence of LB inclusions in ET brains is similar to that in the asymptomatic general population. These incidental LB disease cases have evidence for reduced striatal tyrosine hydroxylase levels, as found in Parkinson’s disease, but there is no evidence for reduced tyrosine hydroxylase levels in ET patients. Reduced mean PC counts in ET cases compared with the controls reported by some studies could not be replicated by others. Most ET cases have the same number of PCs as controls of a comparable age. Neither the lower brainstem LB inclusions nor the cerebellar PC loss represent the neurodegenerative basis of ET. Further studies are needed to determine the pathophysiology of ET.</p></abstract><funding-group><award-group><funding-source country="United States">National Institute on Aging : NIA</funding-source><award-id>P30 AG019610 || AG</award-id></award-group></funding-group></article-meta></front></pmc><affiliations><list><country><li>Canada</li><li>États-Unis</li></country></list><tree><country name="Canada"><noRegion><name sortKey="Rajput, Ali H" sort="Rajput, Ali H" uniqKey="Rajput A" first="Ali H" last="Rajput">Ali H. Rajput</name></noRegion><name sortKey="Rajput, Alex" sort="Rajput, Alex" uniqKey="Rajput A" first="Alex" last="Rajput">Alex Rajput</name></country><country name="États-Unis"><noRegion><name sortKey="Adler, Charles H" sort="Adler, Charles H" uniqKey="Adler C" first="Charles H" last="Adler">Charles H. Adler</name></noRegion><name sortKey="Shill, Holly A" sort="Shill, Holly A" uniqKey="Shill H" first="Holly A" last="Shill">Holly A. Shill</name></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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