Intranasal Delivery of Neural Stem/Progenitor Cells: A Noninvasive Passage to Target Intracerebral Glioma
Identifieur interne : 000810 ( Pmc/Checkpoint ); précédent : 000809; suivant : 000811Intranasal Delivery of Neural Stem/Progenitor Cells: A Noninvasive Passage to Target Intracerebral Glioma
Auteurs : Matthias Reitz ; Maria Demestre ; Jan Sedlacik [Allemagne] ; Hildegard Meissner ; Jens Fiehler [Allemagne] ; Seung U. Kim [Corée du Sud, Canada] ; Manfred Westphal ; Nils Ole SchmidtSource :
- Stem Cells Translational Medicine [ 2157-6564 ] ; 2012.
Abstract
This study investigates the feasibility of intranasal administration of neural stem/progenitor cells (NSPCs) as an alternative, noninvasive, and direct passage for the delivery of stem cells to target intracerebral pathologies such as malignant gliomas. Intranasal administration offers the possibility of multiple treatments potentially using tumor-targeting NSPCs with different therapeutic payloads during the disease course.
Url:
DOI: 10.5966/sctm.2012-0045
PubMed: 23283548
PubMed Central: 3659670
Affiliations:
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Kim</name><affiliation wicri:level="3"><nlm:aff id="aff3">Medical Research Institute, Chung-Ang University College of Medicine, Seoul, Korea;</nlm:aff><country xml:lang="fr">Corée du Sud</country><wicri:regionArea>Medical Research Institute, Chung-Ang University College of Medicine, Seoul</wicri:regionArea><placeName><settlement type="city">Séoul</settlement></placeName></affiliation><affiliation wicri:level="1"><nlm:aff id="aff4">Division of Neurology, Department of Medicine, University of British Columbia Hospital, Vancouver, British Columbia, Canada</nlm:aff><country xml:lang="fr">Canada</country><wicri:regionArea>Division of Neurology, Department of Medicine, University of British Columbia Hospital, Vancouver, British Columbia</wicri:regionArea><wicri:noRegion>British Columbia</wicri:noRegion></affiliation></author><author><name sortKey="Westphal, Manfred" sort="Westphal, Manfred" uniqKey="Westphal M" first="Manfred" last="Westphal">Manfred Westphal</name><affiliation><nlm:aff id="aff1"></nlm:aff></affiliation></author><author><name sortKey="Schmidt, Nils Ole" sort="Schmidt, Nils Ole" uniqKey="Schmidt N" first="Nils Ole" last="Schmidt">Nils Ole Schmidt</name><affiliation><nlm:aff id="aff1"></nlm:aff></affiliation></author></titleStmt><publicationStmt><idno type="wicri:source">PMC</idno><idno type="pmid">23283548</idno><idno type="pmc">3659670</idno><idno type="url">http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3659670</idno><idno type="RBID">PMC:3659670</idno><idno type="doi">10.5966/sctm.2012-0045</idno><date when="2012">2012</date><idno type="wicri:Area/Pmc/Corpus">000694</idno><idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Corpus" wicri:corpus="PMC">000694</idno><idno type="wicri:Area/Pmc/Curation">000694</idno><idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Curation">000694</idno><idno type="wicri:Area/Pmc/Checkpoint">000810</idno><idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Checkpoint">000810</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en" level="a" type="main">Intranasal Delivery of Neural Stem/Progenitor Cells: A Noninvasive Passage to Target Intracerebral Glioma</title><author><name sortKey="Reitz, Matthias" sort="Reitz, Matthias" uniqKey="Reitz M" first="Matthias" last="Reitz">Matthias Reitz</name><affiliation><nlm:aff id="aff1"></nlm:aff></affiliation></author><author><name sortKey="Demestre, Maria" sort="Demestre, Maria" uniqKey="Demestre M" first="Maria" last="Demestre">Maria Demestre</name><affiliation><nlm:aff id="aff1"></nlm:aff></affiliation></author><author><name sortKey="Sedlacik, Jan" sort="Sedlacik, Jan" uniqKey="Sedlacik J" first="Jan" last="Sedlacik">Jan Sedlacik</name><affiliation wicri:level="3"><nlm:aff id="aff2">Neuroradiology, University Medical Center Hamburg-Eppendorf, Hamburg, Germany;</nlm:aff><country xml:lang="fr">Allemagne</country><wicri:regionArea>Neuroradiology, University Medical Center Hamburg-Eppendorf, Hamburg</wicri:regionArea><placeName><settlement type="city">Hambourg</settlement><region type="land" nuts="2">Hambourg</region></placeName></affiliation></author><author><name sortKey="Meissner, Hildegard" sort="Meissner, Hildegard" uniqKey="Meissner H" first="Hildegard" last="Meissner">Hildegard Meissner</name><affiliation><nlm:aff id="aff1"></nlm:aff></affiliation></author><author><name sortKey="Fiehler, Jens" sort="Fiehler, Jens" uniqKey="Fiehler J" first="Jens" last="Fiehler">Jens Fiehler</name><affiliation wicri:level="3"><nlm:aff id="aff2">Neuroradiology, University Medical Center Hamburg-Eppendorf, Hamburg, Germany;</nlm:aff><country xml:lang="fr">Allemagne</country><wicri:regionArea>Neuroradiology, University Medical Center Hamburg-Eppendorf, Hamburg</wicri:regionArea><placeName><settlement type="city">Hambourg</settlement><region type="land" nuts="2">Hambourg</region></placeName></affiliation></author><author><name sortKey="Kim, Seung U" sort="Kim, Seung U" uniqKey="Kim S" first="Seung U." last="Kim">Seung U. Kim</name><affiliation wicri:level="3"><nlm:aff id="aff3">Medical Research Institute, Chung-Ang University College of Medicine, Seoul, Korea;</nlm:aff><country xml:lang="fr">Corée du Sud</country><wicri:regionArea>Medical Research Institute, Chung-Ang University College of Medicine, Seoul</wicri:regionArea><placeName><settlement type="city">Séoul</settlement></placeName></affiliation><affiliation wicri:level="1"><nlm:aff id="aff4">Division of Neurology, Department of Medicine, University of British Columbia Hospital, Vancouver, British Columbia, Canada</nlm:aff><country xml:lang="fr">Canada</country><wicri:regionArea>Division of Neurology, Department of Medicine, University of British Columbia Hospital, Vancouver, British Columbia</wicri:regionArea><wicri:noRegion>British Columbia</wicri:noRegion></affiliation></author><author><name sortKey="Westphal, Manfred" sort="Westphal, Manfred" uniqKey="Westphal M" first="Manfred" last="Westphal">Manfred Westphal</name><affiliation><nlm:aff id="aff1"></nlm:aff></affiliation></author><author><name sortKey="Schmidt, Nils Ole" sort="Schmidt, Nils Ole" uniqKey="Schmidt N" first="Nils Ole" last="Schmidt">Nils Ole Schmidt</name><affiliation><nlm:aff id="aff1"></nlm:aff></affiliation></author></analytic><series><title level="j">Stem Cells Translational Medicine</title><idno type="ISSN">2157-6564</idno><idno type="eISSN">2157-6580</idno><imprint><date when="2012">2012</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en"><p>This study investigates the feasibility of intranasal administration of neural stem/progenitor cells (NSPCs) as an alternative, noninvasive, and direct passage for the delivery of stem cells to target intracerebral pathologies such as malignant gliomas. Intranasal administration offers the possibility of multiple treatments potentially using tumor-targeting NSPCs with different therapeutic payloads during the disease course.</p></div></front></TEI><pmc article-type="research-article"><pmc-comment>The publisher of this article does not allow downloading of the full text in XML form.</pmc-comment>
<front><journal-meta><journal-id journal-id-type="nlm-ta">Stem Cells Transl Med</journal-id><journal-id journal-id-type="iso-abbrev">Stem Cells Transl Med</journal-id><journal-id journal-id-type="hwp">sctm</journal-id><journal-title-group><journal-title>Stem Cells Translational Medicine</journal-title></journal-title-group><issn pub-type="ppub">2157-6564</issn><issn pub-type="epub">2157-6580</issn><publisher><publisher-name>AlphaMed Press</publisher-name></publisher></journal-meta><article-meta><article-id pub-id-type="pmid">23283548</article-id><article-id pub-id-type="pmc">3659670</article-id><article-id pub-id-type="publisher-id">3812031</article-id><article-id pub-id-type="doi">10.5966/sctm.2012-0045</article-id><article-categories><subj-group subj-group-type="heading"><subject>Tissue-Specific Progenitor and Stem Cells</subject></subj-group></article-categories><title-group><article-title>Intranasal Delivery of Neural Stem/Progenitor Cells: A Noninvasive Passage to Target Intracerebral Glioma</article-title></title-group><contrib-group><contrib contrib-type="author"><name><surname>Reitz</surname><given-names>Matthias</given-names></name><xref ref-type="aff" rid="aff1"><sup>a</sup></xref></contrib><contrib contrib-type="author"><name><surname>Demestre</surname><given-names>Maria</given-names></name><xref ref-type="aff" rid="aff1"><sup>a</sup></xref></contrib><contrib contrib-type="author"><name><surname>Sedlacik</surname><given-names>Jan</given-names></name><xref ref-type="aff" rid="aff2"><sup>b</sup></xref></contrib><contrib contrib-type="author"><name><surname>Meissner</surname><given-names>Hildegard</given-names></name><xref ref-type="aff" rid="aff1"><sup>a</sup></xref></contrib><contrib contrib-type="author"><name><surname>Fiehler</surname><given-names>Jens</given-names></name><xref ref-type="aff" rid="aff2"><sup>b</sup></xref></contrib><contrib contrib-type="author"><name><surname>Kim</surname><given-names>Seung U.</given-names></name><xref ref-type="aff" rid="aff3"><sup>c</sup></xref><xref ref-type="aff" rid="aff4"><sup>d</sup></xref></contrib><contrib contrib-type="author"><name><surname>Westphal</surname><given-names>Manfred</given-names></name><xref ref-type="aff" rid="aff1"><sup>a</sup></xref></contrib><contrib contrib-type="author" corresp="yes"><name><surname>Schmidt</surname><given-names>Nils Ole</given-names></name><xref ref-type="aff" rid="aff1"><sup>a</sup></xref></contrib><aff id="aff1">Departments of<sup>a</sup>Neurosurgery and</aff><aff id="aff2"><sup>b</sup>Neuroradiology, University Medical Center Hamburg-Eppendorf, Hamburg, Germany;</aff><aff id="aff3"><sup>c</sup>Medical Research Institute, Chung-Ang University College of Medicine, Seoul, Korea;</aff><aff id="aff4"><sup>d</sup>Division of Neurology, Department of Medicine, University of British Columbia Hospital, Vancouver, British Columbia, Canada</aff></contrib-group><author-notes><corresp>Correspondence: Nils Ole Schmidt, M.D., Department of Neurosurgery, University Medical Center Hamburg-Eppendorf, Martinistrasse 52, 20246 Hamburg, Germany. Telephone:
<phone>49-40-7410-55592</phone>; Fax:
<fax>49-40-7410-58121</fax>; E-Mail: <email>nschmidt@uke.de</email></corresp></author-notes><pub-date pub-type="ppub"><month>12</month><year>2012</year></pub-date><pub-date pub-type="epub"><day>27</day><month>11</month><year>2012</year></pub-date><volume>1</volume><issue>12</issue><fpage>866</fpage><lpage>873</lpage><history><date date-type="received"><day>29</day><month>4</month><year>2012</year></date><date date-type="accepted"><day>13</day><month>9</month><year>2012</year></date></history><permissions><copyright-statement>©AlphaMed Press 1066-5099/2012/$20.00/0</copyright-statement><copyright-year>2012</copyright-year></permissions><self-uri xlink:title="pdf" xlink:type="simple" xlink:href="sct01212000866.pdf"></self-uri><abstract abstract-type="precis"><p>This study investigates the feasibility of intranasal administration of neural stem/progenitor cells (NSPCs) as an alternative, noninvasive, and direct passage for the delivery of stem cells to target intracerebral pathologies such as malignant gliomas. Intranasal administration offers the possibility of multiple treatments potentially using tumor-targeting NSPCs with different therapeutic payloads during the disease course.</p></abstract><abstract><p>Stem cell-based therapies for neurological disorders, including brain tumors, advance continuously toward clinical trials. Optimized cell delivery to the central nervous system remains a challenge since direct intracerebral injection is an invasive method with low transplantation efficiency. We investigated the feasibility of intranasal administration of neural stem/progenitor cells (NSPCs) as an alternative, noninvasive, and direct passage for the delivery of stem cells to target malignant gliomas. Tumor-targeting and migratory pathways of murine and human NSPCs were investigated by intravital magnetic resonance imaging and in histological time course analyses in the intracerebral U87, NCE-G55T2, and syngenic Gl261 glioblastoma models. Intranasally administered NSPCs displayed a rapid, targeted tumor tropism with significant numbers of NSPCs accumulating specifically at the intracerebral glioma site within 6 hours after intranasal delivery. Histological time series analysis revealed that NSPCs migrated within the first 24 hours mainly via olfactory pathways but also by systemic distribution via the microvasculature of the nasal mucosa. Intranasal application of NSPCs leads to a rapid, targeted migration of cells toward intracerebral gliomas. The directional distribution of cells accumulating intra- and peritumorally makes the intranasal delivery of NSPCs a promising noninvasive and convenient alternative delivery method for the treatment of malignant gliomas with the possibility of multiple dosing regimens.</p></abstract><kwd-group><kwd>Cell transplantation</kwd><kwd>Clinical translation</kwd><kwd>Neural stem cell</kwd><kwd>Glioma</kwd></kwd-group></article-meta></front></pmc><affiliations><list><country><li>Allemagne</li><li>Canada</li><li>Corée du Sud</li></country><region><li>Hambourg</li></region><settlement><li>Hambourg</li><li>Séoul</li></settlement></list><tree><noCountry><name sortKey="Demestre, Maria" sort="Demestre, Maria" uniqKey="Demestre M" first="Maria" last="Demestre">Maria Demestre</name><name sortKey="Meissner, Hildegard" sort="Meissner, Hildegard" uniqKey="Meissner H" first="Hildegard" last="Meissner">Hildegard Meissner</name><name sortKey="Reitz, Matthias" sort="Reitz, Matthias" uniqKey="Reitz M" first="Matthias" last="Reitz">Matthias Reitz</name><name sortKey="Schmidt, Nils Ole" sort="Schmidt, Nils Ole" uniqKey="Schmidt N" first="Nils Ole" last="Schmidt">Nils Ole Schmidt</name><name sortKey="Westphal, Manfred" sort="Westphal, Manfred" uniqKey="Westphal M" first="Manfred" last="Westphal">Manfred Westphal</name></noCountry><country name="Allemagne"><region name="Hambourg"><name sortKey="Sedlacik, Jan" sort="Sedlacik, Jan" uniqKey="Sedlacik J" first="Jan" last="Sedlacik">Jan Sedlacik</name></region><name sortKey="Fiehler, Jens" sort="Fiehler, Jens" uniqKey="Fiehler J" first="Jens" last="Fiehler">Jens Fiehler</name></country><country name="Corée du Sud"><noRegion><name sortKey="Kim, Seung U" sort="Kim, Seung U" uniqKey="Kim S" first="Seung U." last="Kim">Seung U. Kim</name></noRegion></country><country name="Canada"><noRegion><name sortKey="Kim, Seung U" sort="Kim, Seung U" uniqKey="Kim S" first="Seung U." last="Kim">Seung U. Kim</name></noRegion></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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