Health-related quality of life and economic impact of urinary incontinence due to detrusor overactivity associated with a neurologic condition: a systematic review
Identifieur interne : 000646 ( Pmc/Checkpoint ); précédent : 000645; suivant : 000647Health-related quality of life and economic impact of urinary incontinence due to detrusor overactivity associated with a neurologic condition: a systematic review
Auteurs : Crisanta I. Tapia [États-Unis] ; Kristin Khalaf [États-Unis] ; Karina Berenson [États-Unis] ; Denise Globe [États-Unis] ; Michael Chancellor [États-Unis] ; Lesley K. Carr [Canada]Source :
- Health and Quality of Life Outcomes [ 1477-7525 ] ; 2013.
Abstract
Patients with neurologic diseases often have neurogenic detrusor overactivity (NDO), which can result in a loss of voluntary bladder control and uncontrollable urinary incontinence (UI).The impact of UI due to NDO on patients’ lives has not been well studied. The objective of this review was to assess the health-related quality of life (HRQoL) and economic burden in patients with urgency UI due to NDO in select countries in North America, the European Union, Asia, and Australia.
Systematic literature searches and reviews of articles published in English (January 2000 to February 2011) were conducted using MEDLINE®, EMBASE®, and the Cochrane Library. Studies assessing the impact of UI on HRQoL of patients with an underlying neurologic condition of interest (i.e., multiple sclerosis, spinal cord injury, Parkinson’s disease, stroke, or spina bifida) were included. Economic studies in urgency UI also were included.
Of 876 citations generated in the initial search, a total of 27 articles were deemed relevant: 16 articles presented HRQoL data and 11 articles presented information on the economic burden of UI. Humanistic studies used a range of HRQoL instruments to measure HRQoL burden, and the economic studies included different cost components to quantify the economic burden, making meaningful comparisons challenging. Despite this heterogeneity, the literature suggests that HRQoL in patients with UI due to NDO is worse than patients with UI in general or those with the same underlying neurologic condition without UI. In addition, urgency UI also results in substantial economic costs.
Incontinent patients with underlying neurologic conditions have impaired HRQoL as well as substantial economic burden attributable to UI due to NDO. There is a need for urgency UI treatments that improve HRQoL of these patients and alleviate the economic burden of this condition.
Url:
DOI: 10.1186/1477-7525-11-13
PubMed: 23369111
PubMed Central: 3606444
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Tapia</name><affiliation wicri:level="1"><nlm:aff id="I1">Health Economics and Outcomes Research, Covance Market Access Services, Inc., 10300 Camput Point Dr, Suite 225, 92121-1511, San Diego, CA, USA</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Health Economics and Outcomes Research, Covance Market Access Services, Inc., 10300 Camput Point Dr, Suite 225, 92121-1511, San Diego, CA</wicri:regionArea><wicri:noRegion>CA</wicri:noRegion></affiliation></author><author><name sortKey="Khalaf, Kristin" sort="Khalaf, Kristin" uniqKey="Khalaf K" first="Kristin" last="Khalaf">Kristin Khalaf</name><affiliation wicri:level="1"><nlm:aff id="I2">Global Health Outcomes Strategy and Research, Allergan, 2525 Dupont Dr, 92612, Irvine, CA, USA</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Global Health Outcomes Strategy and Research, Allergan, 2525 Dupont Dr, 92612, Irvine, CA</wicri:regionArea><wicri:noRegion>CA</wicri:noRegion></affiliation></author><author><name sortKey="Berenson, Karina" sort="Berenson, Karina" uniqKey="Berenson K" first="Karina" last="Berenson">Karina Berenson</name><affiliation wicri:level="1"><nlm:aff id="I3">Health Economics and Outcomes Research, Covance Market Access Services, Inc., 9801 Washingtonian Blvd, 9th Floor, 20878, Gaithersburg, MD, USA</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Health Economics and Outcomes Research, Covance Market Access Services, Inc., 9801 Washingtonian Blvd, 9th Floor, 20878, Gaithersburg, MD</wicri:regionArea><wicri:noRegion>MD</wicri:noRegion></affiliation></author><author><name sortKey="Globe, Denise" sort="Globe, Denise" uniqKey="Globe D" first="Denise" last="Globe">Denise Globe</name><affiliation wicri:level="1"><nlm:aff id="I2">Global Health Outcomes Strategy and Research, Allergan, 2525 Dupont Dr, 92612, Irvine, CA, USA</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Global Health Outcomes Strategy and Research, Allergan, 2525 Dupont Dr, 92612, Irvine, CA</wicri:regionArea><wicri:noRegion>CA</wicri:noRegion></affiliation></author><author><name sortKey="Chancellor, Michael" sort="Chancellor, Michael" uniqKey="Chancellor M" first="Michael" last="Chancellor">Michael Chancellor</name><affiliation wicri:level="1"><nlm:aff id="I4">Department of Neurourology, William Beaumont Hospital, 3601 West 13 Mile Rd, 48073-6769, Royal Oak, MI, USA</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Neurourology, William Beaumont Hospital, 3601 West 13 Mile Rd, 48073-6769, Royal Oak, MI</wicri:regionArea><wicri:noRegion>MI</wicri:noRegion></affiliation></author><author><name sortKey="Carr, Lesley K" sort="Carr, Lesley K" uniqKey="Carr L" first="Lesley K" last="Carr">Lesley K. 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Tapia</name><affiliation wicri:level="1"><nlm:aff id="I1">Health Economics and Outcomes Research, Covance Market Access Services, Inc., 10300 Camput Point Dr, Suite 225, 92121-1511, San Diego, CA, USA</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Health Economics and Outcomes Research, Covance Market Access Services, Inc., 10300 Camput Point Dr, Suite 225, 92121-1511, San Diego, CA</wicri:regionArea><wicri:noRegion>CA</wicri:noRegion></affiliation></author><author><name sortKey="Khalaf, Kristin" sort="Khalaf, Kristin" uniqKey="Khalaf K" first="Kristin" last="Khalaf">Kristin Khalaf</name><affiliation wicri:level="1"><nlm:aff id="I2">Global Health Outcomes Strategy and Research, Allergan, 2525 Dupont Dr, 92612, Irvine, CA, USA</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Global Health Outcomes Strategy and Research, Allergan, 2525 Dupont Dr, 92612, Irvine, CA</wicri:regionArea><wicri:noRegion>CA</wicri:noRegion></affiliation></author><author><name sortKey="Berenson, Karina" sort="Berenson, Karina" uniqKey="Berenson K" first="Karina" last="Berenson">Karina Berenson</name><affiliation wicri:level="1"><nlm:aff id="I3">Health Economics and Outcomes Research, Covance Market Access Services, Inc., 9801 Washingtonian Blvd, 9th Floor, 20878, Gaithersburg, MD, USA</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Health Economics and Outcomes Research, Covance Market Access Services, Inc., 9801 Washingtonian Blvd, 9th Floor, 20878, Gaithersburg, MD</wicri:regionArea><wicri:noRegion>MD</wicri:noRegion></affiliation></author><author><name sortKey="Globe, Denise" sort="Globe, Denise" uniqKey="Globe D" first="Denise" last="Globe">Denise Globe</name><affiliation wicri:level="1"><nlm:aff id="I2">Global Health Outcomes Strategy and Research, Allergan, 2525 Dupont Dr, 92612, Irvine, CA, USA</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Global Health Outcomes Strategy and Research, Allergan, 2525 Dupont Dr, 92612, Irvine, CA</wicri:regionArea><wicri:noRegion>CA</wicri:noRegion></affiliation></author><author><name sortKey="Chancellor, Michael" sort="Chancellor, Michael" uniqKey="Chancellor M" first="Michael" last="Chancellor">Michael Chancellor</name><affiliation wicri:level="1"><nlm:aff id="I4">Department of Neurourology, William Beaumont Hospital, 3601 West 13 Mile Rd, 48073-6769, Royal Oak, MI, USA</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Neurourology, William Beaumont Hospital, 3601 West 13 Mile Rd, 48073-6769, Royal Oak, MI</wicri:regionArea><wicri:noRegion>MI</wicri:noRegion></affiliation></author><author><name sortKey="Carr, Lesley K" sort="Carr, Lesley K" uniqKey="Carr L" first="Lesley K" last="Carr">Lesley K. Carr</name><affiliation wicri:level="1"><nlm:aff id="I5">Division of Urology, Sunnybrook Health Sciences Centre, 2075 Bayview Ave, Unit MG501, M4N 3M5, Toronto, ON, Canada</nlm:aff><country xml:lang="fr">Canada</country><wicri:regionArea>Division of Urology, Sunnybrook Health Sciences Centre, 2075 Bayview Ave, Unit MG501, M4N 3M5, Toronto, ON</wicri:regionArea><wicri:noRegion>ON</wicri:noRegion></affiliation></author></analytic><series><title level="j">Health and Quality of Life Outcomes</title><idno type="eISSN">1477-7525</idno><imprint><date when="2013">2013</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en"><sec><title>Background</title><p>Patients with neurologic diseases often have neurogenic detrusor overactivity (NDO), which can result in a loss of voluntary bladder control and uncontrollable urinary incontinence (UI).The impact of UI due to NDO on patients’ lives has not been well studied. The objective of this review was to assess the health-related quality of life (HRQoL) and economic burden in patients with urgency UI due to NDO in select countries in North America, the European Union, Asia, and Australia.</p></sec><sec><title>Methods</title><p>Systematic literature searches and reviews of articles published in English (January 2000 to February 2011) were conducted using MEDLINE®, EMBASE®, and the Cochrane Library. Studies assessing the impact of UI on HRQoL of patients with an underlying neurologic condition of interest (i.e., multiple sclerosis, spinal cord injury, Parkinson’s disease, stroke, or spina bifida) were included. Economic studies in urgency UI also were included.</p></sec><sec><title>Results</title><p>Of 876 citations generated in the initial search, a total of 27 articles were deemed relevant: 16 articles presented HRQoL data and 11 articles presented information on the economic burden of UI. Humanistic studies used a range of HRQoL instruments to measure HRQoL burden, and the economic studies included different cost components to quantify the economic burden, making meaningful comparisons challenging. Despite this heterogeneity, the literature suggests that HRQoL in patients with UI due to NDO is worse than patients with UI in general or those with the same underlying neurologic condition without UI. In addition, urgency UI also results in substantial economic costs.</p></sec><sec><title>Conclusions</title><p>Incontinent patients with underlying neurologic conditions have impaired HRQoL as well as substantial economic burden attributable to UI due to NDO. 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<front><journal-meta><journal-id journal-id-type="nlm-ta">Health Qual Life Outcomes</journal-id><journal-id journal-id-type="iso-abbrev">Health Qual Life Outcomes</journal-id><journal-title-group><journal-title>Health and Quality of Life Outcomes</journal-title></journal-title-group><issn pub-type="epub">1477-7525</issn><publisher><publisher-name>BioMed Central</publisher-name></publisher></journal-meta><article-meta><article-id pub-id-type="pmid">23369111</article-id><article-id pub-id-type="pmc">3606444</article-id><article-id pub-id-type="publisher-id">1477-7525-11-13</article-id><article-id pub-id-type="doi">10.1186/1477-7525-11-13</article-id><article-categories><subj-group subj-group-type="heading"><subject>Review</subject></subj-group></article-categories><title-group><article-title>Health-related quality of life and economic impact of urinary incontinence due to detrusor overactivity associated with a neurologic condition: a systematic review</article-title></title-group><contrib-group><contrib contrib-type="author" id="A1"><name><surname>Tapia</surname><given-names>Crisanta I</given-names></name><xref ref-type="aff" rid="I1">1</xref><email>Crisanta.Tapia@covance.com</email></contrib><contrib contrib-type="author" corresp="yes" id="A2"><name><surname>Khalaf</surname><given-names>Kristin</given-names></name><xref ref-type="aff" rid="I2">2</xref><email>Khalaf_Kristin@Allergan.com</email></contrib><contrib contrib-type="author" id="A3"><name><surname>Berenson</surname><given-names>Karina</given-names></name><xref ref-type="aff" rid="I3">3</xref><email>Karina.Berenson@covance.com</email></contrib><contrib contrib-type="author" id="A4"><name><surname>Globe</surname><given-names>Denise</given-names></name><xref ref-type="aff" rid="I2">2</xref><email>Globe_Denise@Allergan.com</email></contrib><contrib contrib-type="author" id="A5"><name><surname>Chancellor</surname><given-names>Michael</given-names></name><xref ref-type="aff" rid="I4">4</xref><email>chancellormb@gmail.com</email></contrib><contrib contrib-type="author" id="A6"><name><surname>Carr</surname><given-names>Lesley K</given-names></name><xref ref-type="aff" rid="I5">5</xref><email>Lesley.Carr@sunnybrook.ca</email></contrib></contrib-group><aff id="I1"><label>1</label>Health Economics and Outcomes Research, Covance Market Access Services, Inc., 10300 Camput Point Dr, Suite 225, 92121-1511, San Diego, CA, USA</aff><aff id="I2"><label>2</label>Global Health Outcomes Strategy and Research, Allergan, 2525 Dupont Dr, 92612, Irvine, CA, USA</aff><aff id="I3"><label>3</label>Health Economics and Outcomes Research, Covance Market Access Services, Inc., 9801 Washingtonian Blvd, 9th Floor, 20878, Gaithersburg, MD, USA</aff><aff id="I4"><label>4</label>Department of Neurourology, William Beaumont Hospital, 3601 West 13 Mile Rd, 48073-6769, Royal Oak, MI, USA</aff><aff id="I5"><label>5</label>Division of Urology, Sunnybrook Health Sciences Centre, 2075 Bayview Ave, Unit MG501, M4N 3M5, Toronto, ON, Canada</aff><pub-date pub-type="collection"><year>2013</year></pub-date><pub-date pub-type="epub"><day>31</day><month>1</month><year>2013</year></pub-date><volume>11</volume><fpage>13</fpage><lpage>13</lpage><history><date date-type="received"><day>2</day><month>7</month><year>2012</year></date><date date-type="accepted"><day>25</day><month>1</month><year>2013</year></date></history><permissions><copyright-statement>Copyright ©2013 Tapia et al.; licensee BioMed Central Ltd.</copyright-statement><copyright-year>2013</copyright-year><copyright-holder>Tapia et al.; licensee BioMed Central Ltd.</copyright-holder><license license-type="open-access" xlink:href="http://creativecommons.org/licenses/by/2.0"><license-p>This is an Open Access article distributed under the terms of the Creative Commons Attribution License (<ext-link ext-link-type="uri" xlink:href="http://creativecommons.org/licenses/by/2.0">http://creativecommons.org/licenses/by/2.0</ext-link>), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.</license-p></license></permissions><self-uri xlink:href="http://www.hqlo.com/content/11/1/13"></self-uri><abstract><sec><title>Background</title><p>Patients with neurologic diseases often have neurogenic detrusor overactivity (NDO), which can result in a loss of voluntary bladder control and uncontrollable urinary incontinence (UI).The impact of UI due to NDO on patients’ lives has not been well studied. The objective of this review was to assess the health-related quality of life (HRQoL) and economic burden in patients with urgency UI due to NDO in select countries in North America, the European Union, Asia, and Australia.</p></sec><sec><title>Methods</title><p>Systematic literature searches and reviews of articles published in English (January 2000 to February 2011) were conducted using MEDLINE®, EMBASE®, and the Cochrane Library. Studies assessing the impact of UI on HRQoL of patients with an underlying neurologic condition of interest (i.e., multiple sclerosis, spinal cord injury, Parkinson’s disease, stroke, or spina bifida) were included. Economic studies in urgency UI also were included.</p></sec><sec><title>Results</title><p>Of 876 citations generated in the initial search, a total of 27 articles were deemed relevant: 16 articles presented HRQoL data and 11 articles presented information on the economic burden of UI. Humanistic studies used a range of HRQoL instruments to measure HRQoL burden, and the economic studies included different cost components to quantify the economic burden, making meaningful comparisons challenging. Despite this heterogeneity, the literature suggests that HRQoL in patients with UI due to NDO is worse than patients with UI in general or those with the same underlying neurologic condition without UI. In addition, urgency UI also results in substantial economic costs.</p></sec><sec><title>Conclusions</title><p>Incontinent patients with underlying neurologic conditions have impaired HRQoL as well as substantial economic burden attributable to UI due to NDO. There is a need for urgency UI treatments that improve HRQoL of these patients and alleviate the economic burden of this condition.</p></sec></abstract><kwd-group><kwd>Urinary incontinence</kwd><kwd>Overactive bladder</kwd><kwd>Quality of life</kwd><kwd>Burden of illness</kwd><kwd>Health resources</kwd><kwd>Economic burden</kwd></kwd-group></article-meta></front></pmc><affiliations><list><country><li>Canada</li><li>États-Unis</li></country></list><tree><country name="États-Unis"><noRegion><name sortKey="Tapia, Crisanta I" sort="Tapia, Crisanta I" uniqKey="Tapia C" first="Crisanta I" last="Tapia">Crisanta I. Tapia</name></noRegion><name sortKey="Berenson, Karina" sort="Berenson, Karina" uniqKey="Berenson K" first="Karina" last="Berenson">Karina Berenson</name><name sortKey="Chancellor, Michael" sort="Chancellor, Michael" uniqKey="Chancellor M" first="Michael" last="Chancellor">Michael Chancellor</name><name sortKey="Globe, Denise" sort="Globe, Denise" uniqKey="Globe D" first="Denise" last="Globe">Denise Globe</name><name sortKey="Khalaf, Kristin" sort="Khalaf, Kristin" uniqKey="Khalaf K" first="Kristin" last="Khalaf">Kristin Khalaf</name></country><country name="Canada"><noRegion><name sortKey="Carr, Lesley K" sort="Carr, Lesley K" uniqKey="Carr L" first="Lesley K" last="Carr">Lesley K. Carr</name></noRegion></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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