ParkinsonCanadaV1, Pmc, Checkpoint, bibRecord, 000451

Linking neuroscience with modern concepts of impulse control disorders in Parkinson’s disease

Identifieur interne : 000451 ( Pmc/Checkpoint ); précédent : 000450; suivant : 000452

Linking neuroscience with modern concepts of impulse control disorders in Parkinson’s disease

Auteurs : T. Celeste Napier [États-Unis] ; Jean-Christophe Corvol [France] ; Anthony A. Grace [États-Unis] ; Jamie D. Roitman [États-Unis] ; James Rowe [Royaume-Uni] ; Valerie Voon [Royaume-Uni] ; Antonio P. Strafella [Canada]

Source :

Movement disorders : official journal of the Movement Disorder Society [ 0885-3185 ] ; 2014.

RBID : PMC:4318759

Abstract

Patients with Parkinson’s disease (PD) may experience impulse control disorders (ICDs) when on dopamine agonist therapy for their motor symptoms. In the last few years, there has been a rapid growth of interest for the recognition of these aberrant behaviors and their neurobiological correlates. Recent advances in neuroimaging are helping to identify the neuroanatomical networks responsible for these ICDs, and together with psychopharmacological assessments are providing new insights into the brain status of impulsive behavior. The genetic associations that may be unique to ICDs in PD are also being identified. Complementing human studies, electrophysiological and biochemical studies in animal models are providing insights into neuropathological mechanisms associated with these disorders. New animal models of ICDs in PD patients are being implemented that should provide critical means to identify efficacious therapies for PD-related motor deficits while avoiding ICD side effects. Here, we provide an overview of these recent advances, with a particular emphasis on the neurobiological correlates reported in animal models and patients along with their genetic underpinnings.

Url:

http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4318759

DOI: 10.1002/mds.26068
PubMed: 25476402
PubMed Central: 4318759

Affiliations:

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<front><div type="abstract" xml:lang="en"><p id="P2">Patients with Parkinson’s disease (PD) may experience impulse control disorders (ICDs) when on dopamine agonist therapy for their motor symptoms. In the last few years, there has been a rapid growth of interest for the recognition of these aberrant behaviors and their neurobiological correlates. Recent advances in neuroimaging are helping to identify the neuroanatomical networks responsible for these ICDs, and together with psychopharmacological assessments are providing new insights into the brain status of impulsive behavior. The genetic associations that may be unique to ICDs in PD are also being identified. Complementing human studies, electrophysiological and biochemical studies in animal models are providing insights into neuropathological mechanisms associated with these disorders. New animal models of ICDs in PD patients are being implemented that should provide critical means to identify efficacious therapies for PD-related motor deficits while avoiding ICD side effects. Here, we provide an overview of these recent advances, with a particular emphasis on the neurobiological correlates reported in animal models and patients along with their genetic underpinnings.</p>
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<title-group><article-title>Linking neuroscience with modern concepts of impulse control disorders in Parkinson’s disease</article-title>
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<contrib-group><contrib contrib-type="author"><name><surname>Napier</surname>
<given-names>T. Celeste</given-names>
</name>
<xref ref-type="aff" rid="A1">1</xref>
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<contrib contrib-type="author"><name><surname>Corvol</surname>
<given-names>Jean-Christophe</given-names>
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<xref ref-type="aff" rid="A2">2</xref>
<xref ref-type="author-notes" rid="FN1">*</xref>
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<contrib contrib-type="author"><name><surname>Grace</surname>
<given-names>Anthony A.</given-names>
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<contrib contrib-type="author"><name><surname>Roitman</surname>
<given-names>Jamie D.</given-names>
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<xref ref-type="aff" rid="A4">4</xref>
<xref ref-type="author-notes" rid="FN1">*</xref>
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<contrib contrib-type="author"><name><surname>Rowe</surname>
<given-names>James</given-names>
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<xref ref-type="aff" rid="A5">5</xref>
<xref ref-type="author-notes" rid="FN1">*</xref>
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<contrib contrib-type="author"><name><surname>Voon</surname>
<given-names>Valerie</given-names>
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<xref ref-type="aff" rid="A6">6</xref>
<xref ref-type="author-notes" rid="FN1">*</xref>
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<contrib contrib-type="author"><name><surname>Strafella</surname>
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<aff id="A1"><label>1</label>
Departments of Pharmacology and Psychiatry, Center for Compulsive Behavior and Addiction, Rush University Medical Center, Chicago, IL, USA</aff>
<aff id="A2"><label>2</label>
UPMC, APHP, ICM, INSERM CIC-1422 and UMRS 1027, Department of Neurology, Pitié-Salpêtrière Hospital, Paris, France</aff>
<aff id="A3"><label>3</label>
Departments of Neuroscience, Psychiatry and Psychology, Center for Neuroscience, University of Pittsburgh, Pittsburgh, PA, USA</aff>
<aff id="A4"><label>4</label>
Department of Psychology and Laboratory of Integrative Neuroscience, University of Illinois at Chicago, Chicago, IL USA</aff>
<aff id="A5"><label>5</label>
Department of Clinical Neurosciences; Behavioural and Clinical Neuroscience Institute; and Medical Research Council Cognition and Brain Sciences Unit, University of Cambridge, Cambridge, UK</aff>
<aff id="A6"><label>6</label>
Department of Clinical Neurosciences; University of Cambridge, Cambridge, UK</aff>
<aff id="A7"><label>7</label>
Morton and Gloria Shulman Movement Disorder Unit - E.J. Safra Parkinson Disease Program, Toronto Western Hospital and Research Institute, UHN & Research Imaging Centre, Centre for Addiction and Mental Health, University of Toronto, Ontario, Canada</aff>
<author-notes><corresp id="cor1"><bold>Corresponding Author:</bold>
 1. T. Celeste Napier, Ph.D., Director, Center for Compulsive Behavior and Addiction, Professor, Departments of Pharmacology and Psychiatry, Rush University Medical Center, Suites 424 and 426, Cohn Research Building, 1735 W. Harrison Str., Chicago 60612, voice phone: 312 563-2428, Fax: 312 563-2403, <email>Celeste_Napier@Rush.edu</email>
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<fn id="FN1" fn-type="equal"><label>*</label>
<p id="P1">These authors contributed equally to this report; names listed alphabetically.</p>
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<pub-date pub-type="nihms-submitted"><day>29</day>
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<year>2014</year>
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<year>2014</year>
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<pub-date pub-type="ppub"><month>2</month>
<year>2015</year>
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<pub-date pub-type="pmc-release"><day>01</day>
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<volume>30</volume>
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<lpage>149</lpage>
<pmc-comment>elocation-id from pubmed: 10.1002/mds.26068</pmc-comment>
      <abstract><p id="P2">Patients with Parkinson’s disease (PD) may experience impulse control disorders (ICDs) when on dopamine agonist therapy for their motor symptoms. In the last few years, there has been a rapid growth of interest for the recognition of these aberrant behaviors and their neurobiological correlates. Recent advances in neuroimaging are helping to identify the neuroanatomical networks responsible for these ICDs, and together with psychopharmacological assessments are providing new insights into the brain status of impulsive behavior. The genetic associations that may be unique to ICDs in PD are also being identified. Complementing human studies, electrophysiological and biochemical studies in animal models are providing insights into neuropathological mechanisms associated with these disorders. New animal models of ICDs in PD patients are being implemented that should provide critical means to identify efficacious therapies for PD-related motor deficits while avoiding ICD side effects. Here, we provide an overview of these recent advances, with a particular emphasis on the neurobiological correlates reported in animal models and patients along with their genetic underpinnings.</p>
</abstract>
<kwd-group><kwd>Dopamine agonists</kwd>
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<kwd>basal ganglia</kwd>
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<tree><country name="États-Unis"><noRegion><name sortKey="Napier, T Celeste" sort="Napier, T Celeste" uniqKey="Napier T" first="T. Celeste" last="Napier">T. Celeste Napier</name>
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<country name="France"><region name="Île-de-France"><name sortKey="Corvol, Jean Christophe" sort="Corvol, Jean Christophe" uniqKey="Corvol J" first="Jean-Christophe" last="Corvol">Jean-Christophe Corvol</name>
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<country name="Canada"><region name="Ontario"><name sortKey="Strafella, Antonio P" sort="Strafella, Antonio P" uniqKey="Strafella A" first="Antonio P." last="Strafella">Antonio P. Strafella</name>
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	La maladie de Parkinson au Canada (serveur d'exploration)
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La maladie de Parkinson au Canada (serveur d'exploration)

Linking neuroscience with modern concepts of impulse control disorders in Parkinson’s disease

Linking neuroscience with modern concepts of impulse control disorders in Parkinson’s disease

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