Studying variability in human brain aging in a population-based German cohort—rationale and design of 1000BRAINS
Identifieur interne : 000409 ( Pmc/Checkpoint ); précédent : 000408; suivant : 000410Studying variability in human brain aging in a population-based German cohort—rationale and design of 1000BRAINS
Auteurs : Svenja Caspers [Allemagne] ; Susanne Moebus [Allemagne] ; Silke Lux [Allemagne] ; Noreen Pundt [Allemagne] ; Holger Schütz [Allemagne] ; Thomas W. Mühleisen [Allemagne] ; Vincent Gras [Allemagne] ; Simon B. Eickhoff [Allemagne] ; Sandro Romanzetti [Allemagne] ; Tony Stöcker [Allemagne] ; Rüdiger Stirnberg [Allemagne] ; Mehmet E. Kirlangic [Allemagne] ; Martina Minnerop [Allemagne] ; Peter Pieperhoff [Allemagne] ; Ulrich Mödder [Allemagne] ; Samir Das [Canada] ; Alan C. Evans [Canada] ; Karl-Heinz Jöckel [Allemagne] ; Raimund Erbel [Allemagne] ; Sven Cichon [Allemagne, Suisse] ; Markus M. Nöthen [Allemagne] ; Dieter Sturma [Allemagne] ; Andreas Bauer [Allemagne] ; N. Jon Shah [Allemagne] ; Karl Zilles [Allemagne] ; Katrin Amunts [Allemagne]Source :
- Frontiers in Aging Neuroscience [ 1663-4365 ] ; 2014.
Abstract
The ongoing 1000 brains study (1000BRAINS) is an epidemiological and neuroscientific investigation of structural and functional variability in the human brain during aging. The two recruitment sources are the 10-year follow-up cohort of the German Heinz Nixdorf Recall (HNR) Study, and the HNR MultiGeneration Study cohort, which comprises spouses and offspring of HNR subjects. The HNR is a longitudinal epidemiological investigation of cardiovascular risk factors, with a comprehensive collection of clinical, laboratory, socioeconomic, and environmental data from population-based subjects aged 45–75 years on inclusion. HNR subjects underwent detailed assessments in 2000, 2006, and 2011, and completed annual postal questionnaires on health status. 1000BRAINS accesses these HNR data and applies a separate protocol comprising: neuropsychological tests of attention, memory, executive functions and language; examination of motor skills; ratings of personality, life quality, mood and daily activities; analysis of laboratory and genetic data; and state-of-the-art magnetic resonance imaging (MRI, 3 Tesla) of the brain. The latter includes (i) 3D-T1- and 3D-T2-weighted scans for structural analyses and myelin mapping; (ii) three diffusion imaging sequences optimized for diffusion tensor imaging, high-angular resolution diffusion imaging for detailed fiber tracking and for diffusion kurtosis imaging; (iii) resting-state and task-based functional MRI; and (iv) fluid-attenuated inversion recovery and MR angiography for the detection of vascular lesions and the mapping of white matter lesions. The unique design of 1000BRAINS allows: (i) comprehensive investigation of various influences including genetics, environment and health status on variability in brain structure and function during aging; and (ii) identification of the impact of selected influencing factors on specific cognitive subsystems and their anatomical correlates.
Url:
DOI: 10.3389/fnagi.2014.00149
PubMed: 25071558
PubMed Central: 4094912
Affiliations:
Links toward previous steps (curation, corpus...)
Links to Exploration step
PMC:4094912Le document en format XML
<record><TEI><teiHeader><fileDesc><titleStmt><title xml:lang="en">Studying variability in human brain aging in a population-based German cohort—rationale and design of 1000BRAINS</title><author><name sortKey="Caspers, Svenja" sort="Caspers, Svenja" uniqKey="Caspers S" first="Svenja" last="Caspers">Svenja Caspers</name><affiliation wicri:level="1"><nlm:aff id="aff1"><institution>Institute of Neuroscience and Medicine (INM-1, INM-2, INM-4, INM-8), Research Centre Jülich</institution><country>Jülich, Germany</country></nlm:aff><country xml:lang="fr">Allemagne</country><wicri:regionArea></wicri:regionArea></affiliation></author><author><name sortKey="Moebus, Susanne" sort="Moebus, Susanne" uniqKey="Moebus S" first="Susanne" last="Moebus">Susanne Moebus</name><affiliation wicri:level="1"><nlm:aff id="aff2"><institution>Institute of Medical Informatics, Biometry and Epidemiology, University of Duisburg-Essen</institution><country>Essen, Germany</country></nlm:aff><country xml:lang="fr">Allemagne</country><wicri:regionArea></wicri:regionArea></affiliation></author><author><name sortKey="Lux, Silke" sort="Lux, Silke" uniqKey="Lux S" first="Silke" last="Lux">Silke Lux</name><affiliation wicri:level="1"><nlm:aff id="aff1"><institution>Institute of Neuroscience and Medicine (INM-1, INM-2, INM-4, INM-8), Research Centre Jülich</institution><country>Jülich, Germany</country></nlm:aff><country xml:lang="fr">Allemagne</country><wicri:regionArea></wicri:regionArea></affiliation></author><author><name sortKey="Pundt, Noreen" sort="Pundt, Noreen" uniqKey="Pundt N" first="Noreen" last="Pundt">Noreen Pundt</name><affiliation wicri:level="1"><nlm:aff id="aff2"><institution>Institute of Medical Informatics, Biometry and Epidemiology, University of Duisburg-Essen</institution><country>Essen, Germany</country></nlm:aff><country xml:lang="fr">Allemagne</country><wicri:regionArea></wicri:regionArea></affiliation></author><author><name sortKey="Schutz, Holger" sort="Schutz, Holger" uniqKey="Schutz H" first="Holger" last="Schütz">Holger Schütz</name><affiliation wicri:level="1"><nlm:aff id="aff1"><institution>Institute of Neuroscience and Medicine (INM-1, INM-2, INM-4, INM-8), Research Centre Jülich</institution><country>Jülich, Germany</country></nlm:aff><country xml:lang="fr">Allemagne</country><wicri:regionArea></wicri:regionArea></affiliation></author><author><name sortKey="Muhleisen, Thomas W" sort="Muhleisen, Thomas W" uniqKey="Muhleisen T" first="Thomas W." last="Mühleisen">Thomas W. Mühleisen</name><affiliation wicri:level="1"><nlm:aff id="aff1"><institution>Institute of Neuroscience and Medicine (INM-1, INM-2, INM-4, INM-8), Research Centre Jülich</institution><country>Jülich, Germany</country></nlm:aff><country xml:lang="fr">Allemagne</country><wicri:regionArea></wicri:regionArea></affiliation><affiliation wicri:level="1"><nlm:aff id="aff3"><institution>Department of Genomics, Life & Brain Center, University of Bonn</institution><country>Bonn, Germany</country></nlm:aff><country xml:lang="fr">Allemagne</country><wicri:regionArea></wicri:regionArea></affiliation><affiliation wicri:level="1"><nlm:aff id="aff4"><institution>Institute of Human Genetics, University of Bonn</institution><country>Bonn, Germany</country></nlm:aff><country xml:lang="fr">Allemagne</country><wicri:regionArea></wicri:regionArea></affiliation></author><author><name sortKey="Gras, Vincent" sort="Gras, Vincent" uniqKey="Gras V" first="Vincent" last="Gras">Vincent Gras</name><affiliation wicri:level="1"><nlm:aff id="aff1"><institution>Institute of Neuroscience and Medicine (INM-1, INM-2, INM-4, INM-8), Research Centre Jülich</institution><country>Jülich, Germany</country></nlm:aff><country xml:lang="fr">Allemagne</country><wicri:regionArea></wicri:regionArea></affiliation></author><author><name sortKey="Eickhoff, Simon B" sort="Eickhoff, Simon B" uniqKey="Eickhoff S" first="Simon B." last="Eickhoff">Simon B. Eickhoff</name><affiliation wicri:level="1"><nlm:aff id="aff1"><institution>Institute of Neuroscience and Medicine (INM-1, INM-2, INM-4, INM-8), Research Centre Jülich</institution><country>Jülich, Germany</country></nlm:aff><country xml:lang="fr">Allemagne</country><wicri:regionArea></wicri:regionArea></affiliation><affiliation wicri:level="1"><nlm:aff id="aff5"><institution>Institute for Clinical Neuroscience and Medical Psychology, University of Düsseldorf</institution><country>Düsseldorf, Germany</country></nlm:aff><country xml:lang="fr">Allemagne</country><wicri:regionArea></wicri:regionArea></affiliation></author><author><name sortKey="Romanzetti, Sandro" sort="Romanzetti, Sandro" uniqKey="Romanzetti S" first="Sandro" last="Romanzetti">Sandro Romanzetti</name><affiliation wicri:level="1"><nlm:aff id="aff1"><institution>Institute of Neuroscience and Medicine (INM-1, INM-2, INM-4, INM-8), Research Centre Jülich</institution><country>Jülich, Germany</country></nlm:aff><country xml:lang="fr">Allemagne</country><wicri:regionArea></wicri:regionArea></affiliation></author><author><name sortKey="Stocker, Tony" sort="Stocker, Tony" uniqKey="Stocker T" first="Tony" last="Stöcker">Tony Stöcker</name><affiliation wicri:level="1"><nlm:aff id="aff1"><institution>Institute of Neuroscience and Medicine (INM-1, INM-2, INM-4, INM-8), Research Centre Jülich</institution><country>Jülich, Germany</country></nlm:aff><country xml:lang="fr">Allemagne</country><wicri:regionArea></wicri:regionArea></affiliation></author><author><name sortKey="Stirnberg, Rudiger" sort="Stirnberg, Rudiger" uniqKey="Stirnberg R" first="Rüdiger" last="Stirnberg">Rüdiger Stirnberg</name><affiliation wicri:level="1"><nlm:aff id="aff1"><institution>Institute of Neuroscience and Medicine (INM-1, INM-2, INM-4, INM-8), Research Centre Jülich</institution><country>Jülich, Germany</country></nlm:aff><country xml:lang="fr">Allemagne</country><wicri:regionArea></wicri:regionArea></affiliation></author><author><name sortKey="Kirlangic, Mehmet E" sort="Kirlangic, Mehmet E" uniqKey="Kirlangic M" first="Mehmet E." last="Kirlangic">Mehmet E. Kirlangic</name><affiliation wicri:level="1"><nlm:aff id="aff1"><institution>Institute of Neuroscience and Medicine (INM-1, INM-2, INM-4, INM-8), Research Centre Jülich</institution><country>Jülich, Germany</country></nlm:aff><country xml:lang="fr">Allemagne</country><wicri:regionArea></wicri:regionArea></affiliation></author><author><name sortKey="Minnerop, Martina" sort="Minnerop, Martina" uniqKey="Minnerop M" first="Martina" last="Minnerop">Martina Minnerop</name><affiliation wicri:level="1"><nlm:aff id="aff1"><institution>Institute of Neuroscience and Medicine (INM-1, INM-2, INM-4, INM-8), Research Centre Jülich</institution><country>Jülich, Germany</country></nlm:aff><country xml:lang="fr">Allemagne</country><wicri:regionArea></wicri:regionArea></affiliation></author><author><name sortKey="Pieperhoff, Peter" sort="Pieperhoff, Peter" uniqKey="Pieperhoff P" first="Peter" last="Pieperhoff">Peter Pieperhoff</name><affiliation wicri:level="1"><nlm:aff id="aff1"><institution>Institute of Neuroscience and Medicine (INM-1, INM-2, INM-4, INM-8), Research Centre Jülich</institution><country>Jülich, Germany</country></nlm:aff><country xml:lang="fr">Allemagne</country><wicri:regionArea></wicri:regionArea></affiliation></author><author><name sortKey="Modder, Ulrich" sort="Modder, Ulrich" uniqKey="Modder U" first="Ulrich" last="Mödder">Ulrich Mödder</name><affiliation wicri:level="1"><nlm:aff id="aff1"><institution>Institute of Neuroscience and Medicine (INM-1, INM-2, INM-4, INM-8), Research Centre Jülich</institution><country>Jülich, Germany</country></nlm:aff><country xml:lang="fr">Allemagne</country><wicri:regionArea></wicri:regionArea></affiliation></author><author><name sortKey="Das, Samir" sort="Das, Samir" uniqKey="Das S" first="Samir" last="Das">Samir Das</name><affiliation wicri:level="1"><nlm:aff id="aff6"><institution>McConnell Brain Imaging Center, Montreal Neurological Institute, McGill University</institution><country>Montreal, QC, Canada</country></nlm:aff><country xml:lang="fr">Canada</country><wicri:regionArea></wicri:regionArea></affiliation></author><author><name sortKey="Evans, Alan C" sort="Evans, Alan C" uniqKey="Evans A" first="Alan C." last="Evans">Alan C. Evans</name><affiliation wicri:level="1"><nlm:aff id="aff6"><institution>McConnell Brain Imaging Center, Montreal Neurological Institute, McGill University</institution><country>Montreal, QC, Canada</country></nlm:aff><country xml:lang="fr">Canada</country><wicri:regionArea></wicri:regionArea></affiliation></author><author><name sortKey="Jockel, Karl Heinz" sort="Jockel, Karl Heinz" uniqKey="Jockel K" first="Karl-Heinz" last="Jöckel">Karl-Heinz Jöckel</name><affiliation wicri:level="1"><nlm:aff id="aff2"><institution>Institute of Medical Informatics, Biometry and Epidemiology, University of Duisburg-Essen</institution><country>Essen, Germany</country></nlm:aff><country xml:lang="fr">Allemagne</country><wicri:regionArea></wicri:regionArea></affiliation></author><author><name sortKey="Erbel, Raimund" sort="Erbel, Raimund" uniqKey="Erbel R" first="Raimund" last="Erbel">Raimund Erbel</name><affiliation wicri:level="1"><nlm:aff id="aff7"><institution>Department of Cardiology, University of Duisburg-Essen</institution><country>Essen, Germany</country></nlm:aff><country xml:lang="fr">Allemagne</country><wicri:regionArea></wicri:regionArea></affiliation></author><author><name sortKey="Cichon, Sven" sort="Cichon, Sven" uniqKey="Cichon S" first="Sven" last="Cichon">Sven Cichon</name><affiliation wicri:level="1"><nlm:aff id="aff1"><institution>Institute of Neuroscience and Medicine (INM-1, INM-2, INM-4, INM-8), Research Centre Jülich</institution><country>Jülich, Germany</country></nlm:aff><country xml:lang="fr">Allemagne</country><wicri:regionArea></wicri:regionArea></affiliation><affiliation wicri:level="1"><nlm:aff id="aff3"><institution>Department of Genomics, Life & Brain Center, University of Bonn</institution><country>Bonn, Germany</country></nlm:aff><country xml:lang="fr">Allemagne</country><wicri:regionArea></wicri:regionArea></affiliation><affiliation wicri:level="1"><nlm:aff id="aff4"><institution>Institute of Human Genetics, University of Bonn</institution><country>Bonn, Germany</country></nlm:aff><country xml:lang="fr">Allemagne</country><wicri:regionArea></wicri:regionArea></affiliation><affiliation wicri:level="1"><nlm:aff id="aff8"><institution>Division of Medical Genetics, Department of Biomedicine, University of Basel</institution><country>Basel, Switzerland</country></nlm:aff><country xml:lang="fr">Suisse</country><wicri:regionArea></wicri:regionArea></affiliation></author><author><name sortKey="Nothen, Markus M" sort="Nothen, Markus M" uniqKey="Nothen M" first="Markus M." last="Nöthen">Markus M. Nöthen</name><affiliation wicri:level="1"><nlm:aff id="aff3"><institution>Department of Genomics, Life & Brain Center, University of Bonn</institution><country>Bonn, Germany</country></nlm:aff><country xml:lang="fr">Allemagne</country><wicri:regionArea></wicri:regionArea></affiliation><affiliation wicri:level="1"><nlm:aff id="aff4"><institution>Institute of Human Genetics, University of Bonn</institution><country>Bonn, Germany</country></nlm:aff><country xml:lang="fr">Allemagne</country><wicri:regionArea></wicri:regionArea></affiliation></author><author><name sortKey="Sturma, Dieter" sort="Sturma, Dieter" uniqKey="Sturma D" first="Dieter" last="Sturma">Dieter Sturma</name><affiliation wicri:level="1"><nlm:aff id="aff1"><institution>Institute of Neuroscience and Medicine (INM-1, INM-2, INM-4, INM-8), Research Centre Jülich</institution><country>Jülich, Germany</country></nlm:aff><country xml:lang="fr">Allemagne</country><wicri:regionArea></wicri:regionArea></affiliation><affiliation wicri:level="1"><nlm:aff id="aff9"><institution>Institute for Science and Ethics, University of Bonn</institution><country>Bonn, Germany</country></nlm:aff><country xml:lang="fr">Allemagne</country><wicri:regionArea></wicri:regionArea></affiliation></author><author><name sortKey="Bauer, Andreas" sort="Bauer, Andreas" uniqKey="Bauer A" first="Andreas" last="Bauer">Andreas Bauer</name><affiliation wicri:level="1"><nlm:aff id="aff1"><institution>Institute of Neuroscience and Medicine (INM-1, INM-2, INM-4, INM-8), Research Centre Jülich</institution><country>Jülich, Germany</country></nlm:aff><country xml:lang="fr">Allemagne</country><wicri:regionArea></wicri:regionArea></affiliation><affiliation wicri:level="1"><nlm:aff id="aff10"><institution>Department of Neurology, Heinrich-Heine-University Düsseldorf</institution><country>Düsseldorf, Germany</country></nlm:aff><country xml:lang="fr">Allemagne</country><wicri:regionArea></wicri:regionArea></affiliation></author><author><name sortKey="Jon Shah, N" sort="Jon Shah, N" uniqKey="Jon Shah N" first="N." last="Jon Shah">N. Jon Shah</name><affiliation wicri:level="1"><nlm:aff id="aff1"><institution>Institute of Neuroscience and Medicine (INM-1, INM-2, INM-4, INM-8), Research Centre Jülich</institution><country>Jülich, Germany</country></nlm:aff><country xml:lang="fr">Allemagne</country><wicri:regionArea></wicri:regionArea></affiliation><affiliation wicri:level="1"><nlm:aff id="aff11"><institution>JARA-BRAIN, Jülich-Aachen Research Alliance</institution><country>Jülich, Germany</country></nlm:aff><country xml:lang="fr">Allemagne</country><wicri:regionArea></wicri:regionArea></affiliation><affiliation wicri:level="1"><nlm:aff id="aff12"><institution>Department of Neurology, RWTH Aachen University</institution><country>Aachen, Germany</country></nlm:aff><country xml:lang="fr">Allemagne</country><wicri:regionArea></wicri:regionArea></affiliation></author><author><name sortKey="Zilles, Karl" sort="Zilles, Karl" uniqKey="Zilles K" first="Karl" last="Zilles">Karl Zilles</name><affiliation wicri:level="1"><nlm:aff id="aff1"><institution>Institute of Neuroscience and Medicine (INM-1, INM-2, INM-4, INM-8), Research Centre Jülich</institution><country>Jülich, Germany</country></nlm:aff><country xml:lang="fr">Allemagne</country><wicri:regionArea></wicri:regionArea></affiliation><affiliation wicri:level="1"><nlm:aff id="aff11"><institution>JARA-BRAIN, Jülich-Aachen Research Alliance</institution><country>Jülich, Germany</country></nlm:aff><country xml:lang="fr">Allemagne</country><wicri:regionArea></wicri:regionArea></affiliation><affiliation wicri:level="1"><nlm:aff id="aff13"><institution>Department of Psychiatry, Psychotherapy, and Psychosomatics, RWTH Aachen University</institution><country>Aachen, Germany</country></nlm:aff><country xml:lang="fr">Allemagne</country><wicri:regionArea></wicri:regionArea></affiliation></author><author><name sortKey="Amunts, Katrin" sort="Amunts, Katrin" uniqKey="Amunts K" first="Katrin" last="Amunts">Katrin Amunts</name><affiliation wicri:level="1"><nlm:aff id="aff1"><institution>Institute of Neuroscience and Medicine (INM-1, INM-2, INM-4, INM-8), Research Centre Jülich</institution><country>Jülich, Germany</country></nlm:aff><country xml:lang="fr">Allemagne</country><wicri:regionArea></wicri:regionArea></affiliation><affiliation wicri:level="1"><nlm:aff id="aff11"><institution>JARA-BRAIN, Jülich-Aachen Research Alliance</institution><country>Jülich, Germany</country></nlm:aff><country xml:lang="fr">Allemagne</country><wicri:regionArea></wicri:regionArea></affiliation><affiliation wicri:level="1"><nlm:aff id="aff14"><institution>C. and O. Vogt Institute for Brain Research, Heinrich-Heine-University Düsseldorf</institution><country>Düsseldorf, Germany</country></nlm:aff><country xml:lang="fr">Allemagne</country><wicri:regionArea></wicri:regionArea></affiliation></author></titleStmt><publicationStmt><idno type="wicri:source">PMC</idno><idno type="pmid">25071558</idno><idno type="pmc">4094912</idno><idno type="url">http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4094912</idno><idno type="RBID">PMC:4094912</idno><idno type="doi">10.3389/fnagi.2014.00149</idno><date when="2014">2014</date><idno type="wicri:Area/Pmc/Corpus">000958</idno><idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Corpus" wicri:corpus="PMC">000958</idno><idno type="wicri:Area/Pmc/Curation">000958</idno><idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Curation">000958</idno><idno type="wicri:Area/Pmc/Checkpoint">000409</idno><idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Checkpoint">000409</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en" level="a" type="main">Studying variability in human brain aging in a population-based German cohort—rationale and design of 1000BRAINS</title><author><name sortKey="Caspers, Svenja" sort="Caspers, Svenja" uniqKey="Caspers S" first="Svenja" last="Caspers">Svenja Caspers</name><affiliation wicri:level="1"><nlm:aff id="aff1"><institution>Institute of Neuroscience and Medicine (INM-1, INM-2, INM-4, INM-8), Research Centre Jülich</institution><country>Jülich, Germany</country></nlm:aff><country xml:lang="fr">Allemagne</country><wicri:regionArea></wicri:regionArea></affiliation></author><author><name sortKey="Moebus, Susanne" sort="Moebus, Susanne" uniqKey="Moebus S" first="Susanne" last="Moebus">Susanne Moebus</name><affiliation wicri:level="1"><nlm:aff id="aff2"><institution>Institute of Medical Informatics, Biometry and Epidemiology, University of Duisburg-Essen</institution><country>Essen, Germany</country></nlm:aff><country xml:lang="fr">Allemagne</country><wicri:regionArea></wicri:regionArea></affiliation></author><author><name sortKey="Lux, Silke" sort="Lux, Silke" uniqKey="Lux S" first="Silke" last="Lux">Silke Lux</name><affiliation wicri:level="1"><nlm:aff id="aff1"><institution>Institute of Neuroscience and Medicine (INM-1, INM-2, INM-4, INM-8), Research Centre Jülich</institution><country>Jülich, Germany</country></nlm:aff><country xml:lang="fr">Allemagne</country><wicri:regionArea></wicri:regionArea></affiliation></author><author><name sortKey="Pundt, Noreen" sort="Pundt, Noreen" uniqKey="Pundt N" first="Noreen" last="Pundt">Noreen Pundt</name><affiliation wicri:level="1"><nlm:aff id="aff2"><institution>Institute of Medical Informatics, Biometry and Epidemiology, University of Duisburg-Essen</institution><country>Essen, Germany</country></nlm:aff><country xml:lang="fr">Allemagne</country><wicri:regionArea></wicri:regionArea></affiliation></author><author><name sortKey="Schutz, Holger" sort="Schutz, Holger" uniqKey="Schutz H" first="Holger" last="Schütz">Holger Schütz</name><affiliation wicri:level="1"><nlm:aff id="aff1"><institution>Institute of Neuroscience and Medicine (INM-1, INM-2, INM-4, INM-8), Research Centre Jülich</institution><country>Jülich, Germany</country></nlm:aff><country xml:lang="fr">Allemagne</country><wicri:regionArea></wicri:regionArea></affiliation></author><author><name sortKey="Muhleisen, Thomas W" sort="Muhleisen, Thomas W" uniqKey="Muhleisen T" first="Thomas W." last="Mühleisen">Thomas W. Mühleisen</name><affiliation wicri:level="1"><nlm:aff id="aff1"><institution>Institute of Neuroscience and Medicine (INM-1, INM-2, INM-4, INM-8), Research Centre Jülich</institution><country>Jülich, Germany</country></nlm:aff><country xml:lang="fr">Allemagne</country><wicri:regionArea></wicri:regionArea></affiliation><affiliation wicri:level="1"><nlm:aff id="aff3"><institution>Department of Genomics, Life & Brain Center, University of Bonn</institution><country>Bonn, Germany</country></nlm:aff><country xml:lang="fr">Allemagne</country><wicri:regionArea></wicri:regionArea></affiliation><affiliation wicri:level="1"><nlm:aff id="aff4"><institution>Institute of Human Genetics, University of Bonn</institution><country>Bonn, Germany</country></nlm:aff><country xml:lang="fr">Allemagne</country><wicri:regionArea></wicri:regionArea></affiliation></author><author><name sortKey="Gras, Vincent" sort="Gras, Vincent" uniqKey="Gras V" first="Vincent" last="Gras">Vincent Gras</name><affiliation wicri:level="1"><nlm:aff id="aff1"><institution>Institute of Neuroscience and Medicine (INM-1, INM-2, INM-4, INM-8), Research Centre Jülich</institution><country>Jülich, Germany</country></nlm:aff><country xml:lang="fr">Allemagne</country><wicri:regionArea></wicri:regionArea></affiliation></author><author><name sortKey="Eickhoff, Simon B" sort="Eickhoff, Simon B" uniqKey="Eickhoff S" first="Simon B." last="Eickhoff">Simon B. Eickhoff</name><affiliation wicri:level="1"><nlm:aff id="aff1"><institution>Institute of Neuroscience and Medicine (INM-1, INM-2, INM-4, INM-8), Research Centre Jülich</institution><country>Jülich, Germany</country></nlm:aff><country xml:lang="fr">Allemagne</country><wicri:regionArea></wicri:regionArea></affiliation><affiliation wicri:level="1"><nlm:aff id="aff5"><institution>Institute for Clinical Neuroscience and Medical Psychology, University of Düsseldorf</institution><country>Düsseldorf, Germany</country></nlm:aff><country xml:lang="fr">Allemagne</country><wicri:regionArea></wicri:regionArea></affiliation></author><author><name sortKey="Romanzetti, Sandro" sort="Romanzetti, Sandro" uniqKey="Romanzetti S" first="Sandro" last="Romanzetti">Sandro Romanzetti</name><affiliation wicri:level="1"><nlm:aff id="aff1"><institution>Institute of Neuroscience and Medicine (INM-1, INM-2, INM-4, INM-8), Research Centre Jülich</institution><country>Jülich, Germany</country></nlm:aff><country xml:lang="fr">Allemagne</country><wicri:regionArea></wicri:regionArea></affiliation></author><author><name sortKey="Stocker, Tony" sort="Stocker, Tony" uniqKey="Stocker T" first="Tony" last="Stöcker">Tony Stöcker</name><affiliation wicri:level="1"><nlm:aff id="aff1"><institution>Institute of Neuroscience and Medicine (INM-1, INM-2, INM-4, INM-8), Research Centre Jülich</institution><country>Jülich, Germany</country></nlm:aff><country xml:lang="fr">Allemagne</country><wicri:regionArea></wicri:regionArea></affiliation></author><author><name sortKey="Stirnberg, Rudiger" sort="Stirnberg, Rudiger" uniqKey="Stirnberg R" first="Rüdiger" last="Stirnberg">Rüdiger Stirnberg</name><affiliation wicri:level="1"><nlm:aff id="aff1"><institution>Institute of Neuroscience and Medicine (INM-1, INM-2, INM-4, INM-8), Research Centre Jülich</institution><country>Jülich, Germany</country></nlm:aff><country xml:lang="fr">Allemagne</country><wicri:regionArea></wicri:regionArea></affiliation></author><author><name sortKey="Kirlangic, Mehmet E" sort="Kirlangic, Mehmet E" uniqKey="Kirlangic M" first="Mehmet E." last="Kirlangic">Mehmet E. Kirlangic</name><affiliation wicri:level="1"><nlm:aff id="aff1"><institution>Institute of Neuroscience and Medicine (INM-1, INM-2, INM-4, INM-8), Research Centre Jülich</institution><country>Jülich, Germany</country></nlm:aff><country xml:lang="fr">Allemagne</country><wicri:regionArea></wicri:regionArea></affiliation></author><author><name sortKey="Minnerop, Martina" sort="Minnerop, Martina" uniqKey="Minnerop M" first="Martina" last="Minnerop">Martina Minnerop</name><affiliation wicri:level="1"><nlm:aff id="aff1"><institution>Institute of Neuroscience and Medicine (INM-1, INM-2, INM-4, INM-8), Research Centre Jülich</institution><country>Jülich, Germany</country></nlm:aff><country xml:lang="fr">Allemagne</country><wicri:regionArea></wicri:regionArea></affiliation></author><author><name sortKey="Pieperhoff, Peter" sort="Pieperhoff, Peter" uniqKey="Pieperhoff P" first="Peter" last="Pieperhoff">Peter Pieperhoff</name><affiliation wicri:level="1"><nlm:aff id="aff1"><institution>Institute of Neuroscience and Medicine (INM-1, INM-2, INM-4, INM-8), Research Centre Jülich</institution><country>Jülich, Germany</country></nlm:aff><country xml:lang="fr">Allemagne</country><wicri:regionArea></wicri:regionArea></affiliation></author><author><name sortKey="Modder, Ulrich" sort="Modder, Ulrich" uniqKey="Modder U" first="Ulrich" last="Mödder">Ulrich Mödder</name><affiliation wicri:level="1"><nlm:aff id="aff1"><institution>Institute of Neuroscience and Medicine (INM-1, INM-2, INM-4, INM-8), Research Centre Jülich</institution><country>Jülich, Germany</country></nlm:aff><country xml:lang="fr">Allemagne</country><wicri:regionArea></wicri:regionArea></affiliation></author><author><name sortKey="Das, Samir" sort="Das, Samir" uniqKey="Das S" first="Samir" last="Das">Samir Das</name><affiliation wicri:level="1"><nlm:aff id="aff6"><institution>McConnell Brain Imaging Center, Montreal Neurological Institute, McGill University</institution><country>Montreal, QC, Canada</country></nlm:aff><country xml:lang="fr">Canada</country><wicri:regionArea></wicri:regionArea></affiliation></author><author><name sortKey="Evans, Alan C" sort="Evans, Alan C" uniqKey="Evans A" first="Alan C." last="Evans">Alan C. Evans</name><affiliation wicri:level="1"><nlm:aff id="aff6"><institution>McConnell Brain Imaging Center, Montreal Neurological Institute, McGill University</institution><country>Montreal, QC, Canada</country></nlm:aff><country xml:lang="fr">Canada</country><wicri:regionArea></wicri:regionArea></affiliation></author><author><name sortKey="Jockel, Karl Heinz" sort="Jockel, Karl Heinz" uniqKey="Jockel K" first="Karl-Heinz" last="Jöckel">Karl-Heinz Jöckel</name><affiliation wicri:level="1"><nlm:aff id="aff2"><institution>Institute of Medical Informatics, Biometry and Epidemiology, University of Duisburg-Essen</institution><country>Essen, Germany</country></nlm:aff><country xml:lang="fr">Allemagne</country><wicri:regionArea></wicri:regionArea></affiliation></author><author><name sortKey="Erbel, Raimund" sort="Erbel, Raimund" uniqKey="Erbel R" first="Raimund" last="Erbel">Raimund Erbel</name><affiliation wicri:level="1"><nlm:aff id="aff7"><institution>Department of Cardiology, University of Duisburg-Essen</institution><country>Essen, Germany</country></nlm:aff><country xml:lang="fr">Allemagne</country><wicri:regionArea></wicri:regionArea></affiliation></author><author><name sortKey="Cichon, Sven" sort="Cichon, Sven" uniqKey="Cichon S" first="Sven" last="Cichon">Sven Cichon</name><affiliation wicri:level="1"><nlm:aff id="aff1"><institution>Institute of Neuroscience and Medicine (INM-1, INM-2, INM-4, INM-8), Research Centre Jülich</institution><country>Jülich, Germany</country></nlm:aff><country xml:lang="fr">Allemagne</country><wicri:regionArea></wicri:regionArea></affiliation><affiliation wicri:level="1"><nlm:aff id="aff3"><institution>Department of Genomics, Life & Brain Center, University of Bonn</institution><country>Bonn, Germany</country></nlm:aff><country xml:lang="fr">Allemagne</country><wicri:regionArea></wicri:regionArea></affiliation><affiliation wicri:level="1"><nlm:aff id="aff4"><institution>Institute of Human Genetics, University of Bonn</institution><country>Bonn, Germany</country></nlm:aff><country xml:lang="fr">Allemagne</country><wicri:regionArea></wicri:regionArea></affiliation><affiliation wicri:level="1"><nlm:aff id="aff8"><institution>Division of Medical Genetics, Department of Biomedicine, University of Basel</institution><country>Basel, Switzerland</country></nlm:aff><country xml:lang="fr">Suisse</country><wicri:regionArea></wicri:regionArea></affiliation></author><author><name sortKey="Nothen, Markus M" sort="Nothen, Markus M" uniqKey="Nothen M" first="Markus M." last="Nöthen">Markus M. Nöthen</name><affiliation wicri:level="1"><nlm:aff id="aff3"><institution>Department of Genomics, Life & Brain Center, University of Bonn</institution><country>Bonn, Germany</country></nlm:aff><country xml:lang="fr">Allemagne</country><wicri:regionArea></wicri:regionArea></affiliation><affiliation wicri:level="1"><nlm:aff id="aff4"><institution>Institute of Human Genetics, University of Bonn</institution><country>Bonn, Germany</country></nlm:aff><country xml:lang="fr">Allemagne</country><wicri:regionArea></wicri:regionArea></affiliation></author><author><name sortKey="Sturma, Dieter" sort="Sturma, Dieter" uniqKey="Sturma D" first="Dieter" last="Sturma">Dieter Sturma</name><affiliation wicri:level="1"><nlm:aff id="aff1"><institution>Institute of Neuroscience and Medicine (INM-1, INM-2, INM-4, INM-8), Research Centre Jülich</institution><country>Jülich, Germany</country></nlm:aff><country xml:lang="fr">Allemagne</country><wicri:regionArea></wicri:regionArea></affiliation><affiliation wicri:level="1"><nlm:aff id="aff9"><institution>Institute for Science and Ethics, University of Bonn</institution><country>Bonn, Germany</country></nlm:aff><country xml:lang="fr">Allemagne</country><wicri:regionArea></wicri:regionArea></affiliation></author><author><name sortKey="Bauer, Andreas" sort="Bauer, Andreas" uniqKey="Bauer A" first="Andreas" last="Bauer">Andreas Bauer</name><affiliation wicri:level="1"><nlm:aff id="aff1"><institution>Institute of Neuroscience and Medicine (INM-1, INM-2, INM-4, INM-8), Research Centre Jülich</institution><country>Jülich, Germany</country></nlm:aff><country xml:lang="fr">Allemagne</country><wicri:regionArea></wicri:regionArea></affiliation><affiliation wicri:level="1"><nlm:aff id="aff10"><institution>Department of Neurology, Heinrich-Heine-University Düsseldorf</institution><country>Düsseldorf, Germany</country></nlm:aff><country xml:lang="fr">Allemagne</country><wicri:regionArea></wicri:regionArea></affiliation></author><author><name sortKey="Jon Shah, N" sort="Jon Shah, N" uniqKey="Jon Shah N" first="N." last="Jon Shah">N. Jon Shah</name><affiliation wicri:level="1"><nlm:aff id="aff1"><institution>Institute of Neuroscience and Medicine (INM-1, INM-2, INM-4, INM-8), Research Centre Jülich</institution><country>Jülich, Germany</country></nlm:aff><country xml:lang="fr">Allemagne</country><wicri:regionArea></wicri:regionArea></affiliation><affiliation wicri:level="1"><nlm:aff id="aff11"><institution>JARA-BRAIN, Jülich-Aachen Research Alliance</institution><country>Jülich, Germany</country></nlm:aff><country xml:lang="fr">Allemagne</country><wicri:regionArea></wicri:regionArea></affiliation><affiliation wicri:level="1"><nlm:aff id="aff12"><institution>Department of Neurology, RWTH Aachen University</institution><country>Aachen, Germany</country></nlm:aff><country xml:lang="fr">Allemagne</country><wicri:regionArea></wicri:regionArea></affiliation></author><author><name sortKey="Zilles, Karl" sort="Zilles, Karl" uniqKey="Zilles K" first="Karl" last="Zilles">Karl Zilles</name><affiliation wicri:level="1"><nlm:aff id="aff1"><institution>Institute of Neuroscience and Medicine (INM-1, INM-2, INM-4, INM-8), Research Centre Jülich</institution><country>Jülich, Germany</country></nlm:aff><country xml:lang="fr">Allemagne</country><wicri:regionArea></wicri:regionArea></affiliation><affiliation wicri:level="1"><nlm:aff id="aff11"><institution>JARA-BRAIN, Jülich-Aachen Research Alliance</institution><country>Jülich, Germany</country></nlm:aff><country xml:lang="fr">Allemagne</country><wicri:regionArea></wicri:regionArea></affiliation><affiliation wicri:level="1"><nlm:aff id="aff13"><institution>Department of Psychiatry, Psychotherapy, and Psychosomatics, RWTH Aachen University</institution><country>Aachen, Germany</country></nlm:aff><country xml:lang="fr">Allemagne</country><wicri:regionArea></wicri:regionArea></affiliation></author><author><name sortKey="Amunts, Katrin" sort="Amunts, Katrin" uniqKey="Amunts K" first="Katrin" last="Amunts">Katrin Amunts</name><affiliation wicri:level="1"><nlm:aff id="aff1"><institution>Institute of Neuroscience and Medicine (INM-1, INM-2, INM-4, INM-8), Research Centre Jülich</institution><country>Jülich, Germany</country></nlm:aff><country xml:lang="fr">Allemagne</country><wicri:regionArea></wicri:regionArea></affiliation><affiliation wicri:level="1"><nlm:aff id="aff11"><institution>JARA-BRAIN, Jülich-Aachen Research Alliance</institution><country>Jülich, Germany</country></nlm:aff><country xml:lang="fr">Allemagne</country><wicri:regionArea></wicri:regionArea></affiliation><affiliation wicri:level="1"><nlm:aff id="aff14"><institution>C. and O. Vogt Institute for Brain Research, Heinrich-Heine-University Düsseldorf</institution><country>Düsseldorf, Germany</country></nlm:aff><country xml:lang="fr">Allemagne</country><wicri:regionArea></wicri:regionArea></affiliation></author></analytic><series><title level="j">Frontiers in Aging Neuroscience</title><idno type="eISSN">1663-4365</idno><imprint><date when="2014">2014</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en"><p>The ongoing 1000 brains study (1000BRAINS) is an epidemiological and neuroscientific investigation of structural and functional variability in the human brain during aging. The two recruitment sources are the 10-year follow-up cohort of the German Heinz Nixdorf Recall (HNR) Study, and the HNR MultiGeneration Study cohort, which comprises spouses and offspring of HNR subjects. The HNR is a longitudinal epidemiological investigation of cardiovascular risk factors, with a comprehensive collection of clinical, laboratory, socioeconomic, and environmental data from population-based subjects aged 45–75 years on inclusion. HNR subjects underwent detailed assessments in 2000, 2006, and 2011, and completed annual postal questionnaires on health status. 1000BRAINS accesses these HNR data and applies a separate protocol comprising: neuropsychological tests of attention, memory, executive functions and language; examination of motor skills; ratings of personality, life quality, mood and daily activities; analysis of laboratory and genetic data; and state-of-the-art magnetic resonance imaging (MRI, 3 Tesla) of the brain. The latter includes (i) 3D-T1- and 3D-T2-weighted scans for structural analyses and myelin mapping; (ii) three diffusion imaging sequences optimized for diffusion tensor imaging, high-angular resolution diffusion imaging for detailed fiber tracking and for diffusion kurtosis imaging; (iii) resting-state and task-based functional MRI; and (iv) fluid-attenuated inversion recovery and MR angiography for the detection of vascular lesions and the mapping of white matter lesions. The unique design of 1000BRAINS allows: (i) comprehensive investigation of various influences including genetics, environment and health status on variability in brain structure and function during aging; and (ii) identification of the impact of selected influencing factors on specific cognitive subsystems and their anatomical correlates.</p></div></front><back><div1 type="bibliography"><listBibl><biblStruct><analytic><author><name sortKey="Aschenbrenner, S" uniqKey="Aschenbrenner S">S. Aschenbrenner</name></author><author><name sortKey="Tucha, O" uniqKey="Tucha O">O. Tucha</name></author><author><name sortKey="Lange, K W" uniqKey="Lange K">K. W. Lange</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Bartres Faz, D" uniqKey="Bartres Faz D">D. Bartrés-Faz</name></author><author><name sortKey="Arenaza Urquijo, E M" uniqKey="Arenaza Urquijo E">E. M. Arenaza-Urquijo</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="B Umler, G" uniqKey="B Umler G">G. Bäumler</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Beckmann, C F" uniqKey="Beckmann C">C. F. Beckmann</name></author><author><name sortKey="Smith, S M" uniqKey="Smith S">S. M. Smith</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Benton, A L" uniqKey="Benton A">A. L. Benton</name></author><author><name sortKey="Benton Sivan, A" uniqKey="Benton Sivan A">A. Benton-Sivan</name></author><author><name sortKey="Spreen, O" uniqKey="Spreen O">O. Spreen</name></author><author><name sortKey="Streck, P" uniqKey="Streck P">P. Streck</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Berg, K" uniqKey="Berg K">K. Berg</name></author><author><name sortKey="Wood Dauphinee, S" uniqKey="Wood Dauphinee S">S. Wood-Dauphinee</name></author><author><name sortKey="Williams, J I" uniqKey="Williams J">J. I. Williams</name></author><author><name sortKey="Gayton, D" uniqKey="Gayton D">D. Gayton</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Bis, J C" uniqKey="Bis J">J. C. Bis</name></author><author><name sortKey="Decarli, C" uniqKey="Decarli C">C. DeCarli</name></author><author><name sortKey="Smith, A V" uniqKey="Smith A">A. V. Smith</name></author><author><name sortKey="Van Der Lijn, F" uniqKey="Van Der Lijn F">F. van der Lijn</name></author><author><name sortKey="Crivello, F" uniqKey="Crivello F">F. Crivello</name></author><author><name sortKey="Fornage, M" uniqKey="Fornage M">M. Fornage</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Bloem, B R" uniqKey="Bloem B">B. R. Bloem</name></author><author><name sortKey="Steijns, J A" uniqKey="Steijns J">J. A. Steijns</name></author><author><name sortKey="Smits Engelsman, B C" uniqKey="Smits Engelsman B">B. C. Smits-Engelsman</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Bloem, B R" uniqKey="Bloem B">B. R. Bloem</name></author><author><name sortKey="Valkenburg, V V" uniqKey="Valkenburg V">V. V. Valkenburg</name></author><author><name sortKey="Slabbekoorn, M" uniqKey="Slabbekoorn M">M. Slabbekoorn</name></author><author><name sortKey="Willemsen, M D" uniqKey="Willemsen M">M. D. Willemsen</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Boeer, J" uniqKey="Boeer J">J. Boeer</name></author><author><name sortKey="Muller, O" uniqKey="Muller O">O. Müller</name></author><author><name sortKey="Krauss, I" uniqKey="Krauss I">I. Krauss</name></author><author><name sortKey="Haupt, G" uniqKey="Haupt G">G. Haupt</name></author><author><name sortKey="Axmann, D" uniqKey="Axmann D">D. Axmann</name></author><author><name sortKey="Horstmann, T" uniqKey="Horstmann T">T. Horstmann</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Booth, T C" uniqKey="Booth T">T. C. Booth</name></author><author><name sortKey="Jackson, A" uniqKey="Jackson A">A. Jackson</name></author><author><name sortKey="Wardlaw, J M" uniqKey="Wardlaw J">J. M. Wardlaw</name></author><author><name sortKey="Taylor, S A" uniqKey="Taylor S">S. A. Taylor</name></author><author><name sortKey="Waldman, A D" uniqKey="Waldman A">A. D. Waldman</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Brewer, G J" uniqKey="Brewer G">G. J. Brewer</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Brickenkamp, R" uniqKey="Brickenkamp R">R. Brickenkamp</name></author><author><name sortKey="Schmidt Atzert, L" uniqKey="Schmidt Atzert L">L. Schmidt-Atzert</name></author><author><name sortKey="Liepmann, D" uniqKey="Liepmann D">D. Liepmann</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Buatois, S" uniqKey="Buatois S">S. Buatois</name></author><author><name sortKey="Miljkovic, D" uniqKey="Miljkovic D">D. Miljkovic</name></author><author><name sortKey="Manckoundia, P" uniqKey="Manckoundia P">P. Manckoundia</name></author><author><name sortKey="Gueguen, R" uniqKey="Gueguen R">R. Gueguen</name></author><author><name sortKey="Miget, P" uniqKey="Miget P">P. Miget</name></author><author><name sortKey="Vancon, G" uniqKey="Vancon G">G. Vançon</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Bullinger, M" uniqKey="Bullinger M">M. Bullinger</name></author><author><name sortKey="Kirchberger, I" uniqKey="Kirchberger I">I. Kirchberger</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Button, K S" uniqKey="Button K">K. S. Button</name></author><author><name sortKey="Ioannidis, J P A" uniqKey="Ioannidis J">J. P. A. Ioannidis</name></author><author><name sortKey="Mokrysz, C" uniqKey="Mokrysz C">C. Mokrysz</name></author><author><name sortKey="Nosek, B A" uniqKey="Nosek B">B. A. Nosek</name></author><author><name sortKey="Flint, J" uniqKey="Flint J">J. Flint</name></author><author><name sortKey="Robinson, E S J" uniqKey="Robinson E">E. S. J. Robinson</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Cabeza, R" uniqKey="Cabeza R">R. Cabeza</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Caspers, S" uniqKey="Caspers S">S. Caspers</name></author><author><name sortKey="Eickhoff, S B" uniqKey="Eickhoff S">S. B. Eickhoff</name></author><author><name sortKey="Zilles, K" uniqKey="Zilles K">K. Zilles</name></author><author><name sortKey="Amunts, K" uniqKey="Amunts K">K. Amunts</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Das, S" uniqKey="Das S">S. Das</name></author><author><name sortKey="Zijdenbos, A P" uniqKey="Zijdenbos A">A. P. Zijdenbos</name></author><author><name sortKey="Harlap, J" uniqKey="Harlap J">J. Harlap</name></author><author><name sortKey="Vins, D" uniqKey="Vins D">D. Vins</name></author><author><name sortKey="Evans, A C" uniqKey="Evans A">A. C. Evans</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Defer, G L" uniqKey="Defer G">G. L. Defer</name></author><author><name sortKey="Widner, H" uniqKey="Widner H">H. Widner</name></author><author><name sortKey="Marie, R M" uniqKey="Marie R">R. M. Marie</name></author><author><name sortKey="Remy, P" uniqKey="Remy P">P. Remy</name></author><author><name sortKey="Levivier, M" uniqKey="Levivier M">M. Levivier</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="De Groot, J C" uniqKey="De Groot J">J. C. de Groot</name></author><author><name sortKey="De Leeuw, F E" uniqKey="De Leeuw F">F. E. de Leeuw</name></author><author><name sortKey="Oudkerk, M" uniqKey="Oudkerk M">M. Oudkerk</name></author><author><name sortKey="Hofman, A" uniqKey="Hofman A">A. Hofman</name></author><author><name sortKey="Jolles, J" uniqKey="Jolles J">J. Jolles</name></author><author><name sortKey="Breteler, M M" uniqKey="Breteler M">M. M. Breteler</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Della Sala, S" uniqKey="Della Sala S">S. Della Sala</name></author><author><name sortKey="Gray, C" uniqKey="Gray C">C. Gray</name></author><author><name sortKey="Baddeley, A" uniqKey="Baddeley A">A. Baddeley</name></author><author><name sortKey="Wilson, L" uniqKey="Wilson L">L. Wilson</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Depp, C A" uniqKey="Depp C">C. A. Depp</name></author><author><name sortKey="Jeste, D V" uniqKey="Jeste D">D. V. Jeste</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Erbel, R" uniqKey="Erbel R">R. Erbel</name></author><author><name sortKey="Eisele, L" uniqKey="Eisele L">L. Eisele</name></author><author><name sortKey="Moebus, S" uniqKey="Moebus S">S. Moebus</name></author><author><name sortKey="Dragano, N" uniqKey="Dragano N">N. Dragano</name></author><author><name sortKey="Mohlenkamp, S" uniqKey="Mohlenkamp S">S. Möhlenkamp</name></author><author><name sortKey="Bauer, M" uniqKey="Bauer M">M. Bauer</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Erk, S" uniqKey="Erk S">S. Erk</name></author><author><name sortKey="Meyer Lindenberg, A" uniqKey="Meyer Lindenberg A">A. Meyer-Lindenberg</name></author><author><name sortKey="Schnell, K" uniqKey="Schnell K">K. Schnell</name></author><author><name sortKey="Opitz Von Boberfeld, C" uniqKey="Opitz Von Boberfeld C">C. Opitz von Boberfeld</name></author><author><name sortKey="Esslinger, C" uniqKey="Esslinger C">C. Esslinger</name></author><author><name sortKey="Kirsch, P" uniqKey="Kirsch P">P. Kirsch</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Esslinger, C" uniqKey="Esslinger C">C. Esslinger</name></author><author><name sortKey="Walter, H" uniqKey="Walter H">H. Walter</name></author><author><name sortKey="Kirsch, P" uniqKey="Kirsch P">P. Kirsch</name></author><author><name sortKey="Erk, S" uniqKey="Erk S">S. Erk</name></author><author><name sortKey="Schnell, K" uniqKey="Schnell K">K. Schnell</name></author><author><name sortKey="Arnold, C" uniqKey="Arnold C">C. Arnold</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Eyler, L T" uniqKey="Eyler L">L. T. Eyler</name></author><author><name sortKey="Sherzai, A" uniqKey="Sherzai A">A. Sherzai</name></author><author><name sortKey="Kaup, A R" uniqKey="Kaup A">A. R. Kaup</name></author><author><name sortKey="Jeste, D V" uniqKey="Jeste D">D. V. Jeste</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Fahrenberg, J" uniqKey="Fahrenberg J">J. Fahrenberg</name></author><author><name sortKey="Hampel, R" uniqKey="Hampel R">R. Hampel</name></author><author><name sortKey="Selg, H" uniqKey="Selg H">H. Selg</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Gatterer, G" uniqKey="Gatterer G">G. Gatterer</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Goh, J O" uniqKey="Goh J">J. O. Goh</name></author><author><name sortKey="Park, D C" uniqKey="Park D">D. C. Park</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Grady, C L" uniqKey="Grady C">C. L. Grady</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Guralnik, J M" uniqKey="Guralnik J">J. M. Guralnik</name></author><author><name sortKey="Simonsick, E M" uniqKey="Simonsick E">E. M. Simonsick</name></author><author><name sortKey="Ferrucci, L" uniqKey="Ferrucci L">L. Ferrucci</name></author><author><name sortKey="Glynn, R J" uniqKey="Glynn R">R. J. Glynn</name></author><author><name sortKey="Berkman, L F" uniqKey="Berkman L">L. F. Berkman</name></author><author><name sortKey="Blazer, D G" uniqKey="Blazer D">D. G. Blazer</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Haggard, P" uniqKey="Haggard P">P. Haggard</name></author><author><name sortKey="Cockburn, J" uniqKey="Cockburn J">J. Cockburn</name></author><author><name sortKey="Cock, J" uniqKey="Cock J">J. Cock</name></author><author><name sortKey="Fordham, C" uniqKey="Fordham C">C. Fordham</name></author><author><name sortKey="Wade, D" uniqKey="Wade D">D. Wade</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Halstead, W C" uniqKey="Halstead W">W. C. Halstead</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Hautzinger, M" uniqKey="Hautzinger M">M. Hautzinger</name></author><author><name sortKey="Keller, F" uniqKey="Keller F">F. Keller</name></author><author><name sortKey="Kuhner, C" uniqKey="Kuhner C">C. Kühner</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Hegenscheid, K" uniqKey="Hegenscheid K">K. Hegenscheid</name></author><author><name sortKey="Kuhn, J P" uniqKey="Kuhn J">J. P. Kühn</name></author><author><name sortKey="Volzke, H" uniqKey="Volzke H">H. Völzke</name></author><author><name sortKey="Biffar, R" uniqKey="Biffar R">R. Biffar</name></author><author><name sortKey="Hosten, N" uniqKey="Hosten N">N. Hosten</name></author><author><name sortKey="Puls, R" uniqKey="Puls R">R. Puls</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Hegenscheid, K" uniqKey="Hegenscheid K">K. Hegenscheid</name></author><author><name sortKey="Seipel, R" uniqKey="Seipel R">R. Seipel</name></author><author><name sortKey="Schmidt, C O" uniqKey="Schmidt C">C. O. Schmidt</name></author><author><name sortKey="Volzke, H" uniqKey="Volzke H">H. Völzke</name></author><author><name sortKey="Kuhn, J P" uniqKey="Kuhn J">J. P. Kühn</name></author><author><name sortKey="Biffar, R" uniqKey="Biffar R">R. Biffar</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Hofman, A" uniqKey="Hofman A">A. Hofman</name></author><author><name sortKey="Breteler, M M B" uniqKey="Breteler M">M. M. B. Breteler</name></author><author><name sortKey="Van Duijn, C M" uniqKey="Van Duijn C">C. M. van Duijn</name></author><author><name sortKey="Janssen, H L A" uniqKey="Janssen H">H. L. A. Janssen</name></author><author><name sortKey="Krestin, G P" uniqKey="Krestin G">G. P. Krestin</name></author><author><name sortKey="Kuipers, E J" uniqKey="Kuipers E">E. J. Kuipers</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Hofman, A" uniqKey="Hofman A">A. Hofman</name></author><author><name sortKey="Breteler, M M B" uniqKey="Breteler M">M. M. B. Breteler</name></author><author><name sortKey="Van Duijn, C M" uniqKey="Van Duijn C">C. M. van Duijn</name></author><author><name sortKey="Krestin, G P" uniqKey="Krestin G">G. P. Krestin</name></author><author><name sortKey="Pols, H A" uniqKey="Pols H">H. A. Pols</name></author><author><name sortKey="Stricker, B H C" uniqKey="Stricker B">B. H. C. Stricker</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Hofman, A" uniqKey="Hofman A">A. Hofman</name></author><author><name sortKey="Groebbee, D E" uniqKey="Groebbee D">D. E. Groebbee</name></author><author><name sortKey="De Jong, P T V M" uniqKey="De Jong P">P. T. V. M. de Jong</name></author><author><name sortKey="Van Den Ouweland, F A" uniqKey="Van Den Ouweland F">F. A. van den Ouweland</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Hofman, A" uniqKey="Hofman A">A. Hofman</name></author><author><name sortKey="Van Duijn, C M" uniqKey="Van Duijn C">C. M. van Duijn</name></author><author><name sortKey="Franco, O H" uniqKey="Franco O">O. H. Franco</name></author><author><name sortKey="Ikram, M A" uniqKey="Ikram M">M. A. Ikram</name></author><author><name sortKey="Janssen, H L A" uniqKey="Janssen H">H. L. A. Janssen</name></author><author><name sortKey="Klaver, C C W" uniqKey="Klaver C">C. C. W. Klaver</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Ikram, M A" uniqKey="Ikram M">M. A. Ikram</name></author><author><name sortKey="Van Der Lugt, A" uniqKey="Van Der Lugt A">A. van der Lugt</name></author><author><name sortKey="Niessen, W J" uniqKey="Niessen W">W. J. Niessen</name></author><author><name sortKey="Krestin, G P" uniqKey="Krestin G">G. P. Krestin</name></author><author><name sortKey="Koudstaal, P J" uniqKey="Koudstaal P">P. J. Koudstaal</name></author><author><name sortKey="Hofman, A" uniqKey="Hofman A">A. Hofman</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Illes, J" uniqKey="Illes J">J. Illes</name></author><author><name sortKey="Chin, V N" uniqKey="Chin V">V. N. Chin</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Illes, J" uniqKey="Illes J">J. Illes</name></author><author><name sortKey="Kirschen, M P" uniqKey="Kirschen M">M. P. Kirschen</name></author><author><name sortKey="Karetsky, K" uniqKey="Karetsky K">K. Karetsky</name></author><author><name sortKey="Kelly, M" uniqKey="Kelly M">M. Kelly</name></author><author><name sortKey="Saha, A" uniqKey="Saha A">A. Saha</name></author><author><name sortKey="Desmond, J E" uniqKey="Desmond J">J. E. Desmond</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Illes, J" uniqKey="Illes J">J. Illes</name></author><author><name sortKey="Rosen, A C" uniqKey="Rosen A">A. C. Rosen</name></author><author><name sortKey="Huang, L" uniqKey="Huang L">L. Huang</name></author><author><name sortKey="Goldstein, R A" uniqKey="Goldstein R">R. A. Goldstein</name></author><author><name sortKey="Raffin, T A" uniqKey="Raffin T">T. A. Raffin</name></author><author><name sortKey="Swan, G" uniqKey="Swan G">G. Swan</name></author></analytic></biblStruct><biblStruct></biblStruct><biblStruct><analytic><author><name sortKey="Jessen, F" uniqKey="Jessen F">F. Jessen</name></author><author><name sortKey="Wiese, B" uniqKey="Wiese B">B. Wiese</name></author><author><name sortKey="Bachmann, C" uniqKey="Bachmann C">C. Bachmann</name></author><author><name sortKey="Eifflaender Gorfer, S" uniqKey="Eifflaender Gorfer S">S. Eifflaender-Gorfer</name></author><author><name sortKey="Haller, F" uniqKey="Haller F">F. Haller</name></author><author><name sortKey="Kolsch, H" uniqKey="Kolsch H">H. Kolsch</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Jeste, D V" uniqKey="Jeste D">D. V. Jeste</name></author><author><name sortKey="Depp, C A" uniqKey="Depp C">C. A. Depp</name></author><author><name sortKey="Vahia, I V" uniqKey="Vahia I">I. V. Vahia</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Joshi, Y B" uniqKey="Joshi Y">Y. B. Joshi</name></author><author><name sortKey="Pratic, D" uniqKey="Pratic D">D. Praticò</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Kalbe, E" uniqKey="Kalbe E">E. Kalbe</name></author><author><name sortKey="Kessler, J" uniqKey="Kessler J">J. Kessler</name></author><author><name sortKey="Calabrese, P" uniqKey="Calabrese P">P. Calabrese</name></author><author><name sortKey="Smith, R" uniqKey="Smith R">R. Smith</name></author><author><name sortKey="Passmore, A P" uniqKey="Passmore A">A. P. Passmore</name></author><author><name sortKey="Brand, M" uniqKey="Brand M">M. Brand</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Kertesz, A" uniqKey="Kertesz A">A. Kertesz</name></author><author><name sortKey="Davidson, W" uniqKey="Davidson W">W. Davidson</name></author><author><name sortKey="Fox, H" uniqKey="Fox H">H. Fox</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Krampe, R T" uniqKey="Krampe R">R. T. Krampe</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Lachner, C" uniqKey="Lachner C">C. Lachner</name></author><author><name sortKey="Steinle, N I" uniqKey="Steinle N">N. I. Steinle</name></author><author><name sortKey="Regenold, W T" uniqKey="Regenold W">W. T. Regenold</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Lanzerath, D" uniqKey="Lanzerath D">D. Lanzerath</name></author><author><name sortKey="Heinrichs, B" uniqKey="Heinrichs B">B. Heinrichs</name></author><author><name sortKey="Rietschel, M" uniqKey="Rietschel M">M. Rietschel</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Launer, L J" uniqKey="Launer L">L. J. Launer</name></author><author><name sortKey="Oudkerk, M" uniqKey="Oudkerk M">M. Oudkerk</name></author><author><name sortKey="Nilsson, L G" uniqKey="Nilsson L">L. G. Nilsson</name></author><author><name sortKey="Alperovitch, A" uniqKey="Alperovitch A">A. Alperovitch</name></author><author><name sortKey="Berger, K" uniqKey="Berger K">K. Berger</name></author><author><name sortKey="Breteler, M M B" uniqKey="Breteler M">M. M. B. Breteler</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Lopez Otin, C" uniqKey="Lopez Otin C">C. Lopéz-Otín</name></author><author><name sortKey="Blasco, M A" uniqKey="Blasco M">M. A. Blasco</name></author><author><name sortKey="Partridge, L" uniqKey="Partridge L">L. Partridge</name></author><author><name sortKey="Serrano, M" uniqKey="Serrano M">M. Serrano</name></author><author><name sortKey="Kroemer, G" uniqKey="Kroemer G">G. Kroemer</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Luria, A R" uniqKey="Luria A">A. R. Luria</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Lux, S" uniqKey="Lux S">S. Lux</name></author><author><name sortKey="Hartje, W" uniqKey="Hartje W">W. Hartje</name></author><author><name sortKey="Reich, C" uniqKey="Reich C">C. Reich</name></author><author><name sortKey="Nagel, C" uniqKey="Nagel C">C. Nagel</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Maggio, M" uniqKey="Maggio M">M. Maggio</name></author><author><name sortKey="Dall Aglio, E" uniqKey="Dall Aglio E">E. Dall'Aglio</name></author><author><name sortKey="Lauretani, F" uniqKey="Lauretani F">F. Lauretani</name></author><author><name sortKey="Cattabiani, C" uniqKey="Cattabiani C">C. Cattabiani</name></author><author><name sortKey="Ceresini, G" uniqKey="Ceresini G">G. Ceresini</name></author><author><name sortKey="Caffarra, P" uniqKey="Caffarra P">P. Caffarra</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Marian, V" uniqKey="Marian V">V. Marian</name></author><author><name sortKey="Blumenfeld, H K" uniqKey="Blumenfeld H">H. K. Blumenfeld</name></author><author><name sortKey="Kaushanskaya, M" uniqKey="Kaushanskaya M">M. Kaushanskaya</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Martinez Martin, P" uniqKey="Martinez Martin P">P. Martínez-Martín</name></author><author><name sortKey="Gil Nagel, A" uniqKey="Gil Nagel A">A. Gil-Nagel</name></author><author><name sortKey="Gracia, L M" uniqKey="Gracia L">L. M. Gracia</name></author><author><name sortKey="G Mez, J B" uniqKey="G Mez J">J. B. Gómez</name></author><author><name sortKey="Martinez Sarries, J" uniqKey="Martinez Sarries J">J. Martínez-Sarriés</name></author><author><name sortKey="Bermejo, F" uniqKey="Bermejo F">F. Bermejo</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Mcmullin, J A" uniqKey="Mcmullin J">J. A. McMullin</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Meyer Lindenberg, A" uniqKey="Meyer Lindenberg A">A. Meyer-Lindenberg</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Meyer Lindenberg, A" uniqKey="Meyer Lindenberg A">A. Meyer-Lindenberg</name></author><author><name sortKey="Weinberger, D R" uniqKey="Weinberger D">D. R. Weinberger</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Meyer Lindenberg, A" uniqKey="Meyer Lindenberg A">A. Meyer-Lindenberg</name></author><author><name sortKey="Zink, C F" uniqKey="Zink C">C. F. Zink</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Moffat, S D" uniqKey="Moffat S">S. D. Moffat</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Morris, J C" uniqKey="Morris J">J. C. Morris</name></author><author><name sortKey="Heyman, A" uniqKey="Heyman A">A. Heyman</name></author><author><name sortKey="Mohs, R C" uniqKey="Mohs R">R. C. Mohs</name></author><author><name sortKey="Hughes, J P" uniqKey="Hughes J">J. P. Hughes</name></author><author><name sortKey="Van Belle, G" uniqKey="Van Belle G">G. van Belle</name></author><author><name sortKey="Fillenbaum, G" uniqKey="Fillenbaum G">G. Fillenbaum</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Morris, Z" uniqKey="Morris Z">Z. Morris</name></author><author><name sortKey="Whiteley, W N" uniqKey="Whiteley W">W. N. Whiteley</name></author><author><name sortKey="Longstreth, W T" uniqKey="Longstreth W">W. T. Longstreth</name></author><author><name sortKey="Weber, F" uniqKey="Weber F">F. Weber</name></author><author><name sortKey="Lee, Y C" uniqKey="Lee Y">Y. C. Lee</name></author><author><name sortKey="Tsushima, Y" uniqKey="Tsushima Y">Y. Tsushima</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Mowinckel, A M" uniqKey="Mowinckel A">A. M. Mowinckel</name></author><author><name sortKey="Espeseth, T" uniqKey="Espeseth T">T. Espeseth</name></author><author><name sortKey="Westlye, L T" uniqKey="Westlye L">L. T. Westlye</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Mueller, S G" uniqKey="Mueller S">S. G. Mueller</name></author><author><name sortKey="Weiner, M W" uniqKey="Weiner M">M. W. Weiner</name></author><author><name sortKey="Thal, L J" uniqKey="Thal L">L. J. Thal</name></author><author><name sortKey="Petersen, R C" uniqKey="Petersen R">R. C. Petersen</name></author><author><name sortKey="Jack, C" uniqKey="Jack C">C. Jack</name></author><author><name sortKey="Jagust, W" uniqKey="Jagust W">W. Jagust</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Muller, B" uniqKey="Muller B">B. Müller</name></author><author><name sortKey="Basler, H D" uniqKey="Basler H">H. D. Basler</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Muller, O" uniqKey="Muller O">O. Müller</name></author><author><name sortKey="Gunther, M" uniqKey="Gunther M">M. Günther</name></author><author><name sortKey="Krauss, I" uniqKey="Krauss I">I. Krauss</name></author><author><name sortKey="Horstmann, T" uniqKey="Horstmann T">T. Horstmann</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Oldfield, R C" uniqKey="Oldfield R">R. C. Oldfield</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Oswald, W D" uniqKey="Oswald W">W. D. Oswald</name></author><author><name sortKey="Fleischmann, U M" uniqKey="Fleischmann U">U. M. Fleischmann</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Park, D C" uniqKey="Park D">D. C. Park</name></author><author><name sortKey="Reuter Lorenz, P A" uniqKey="Reuter Lorenz P">P. A. Reuter-Lorenz</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Pieperhoff, P" uniqKey="Pieperhoff P">P. Pieperhoff</name></author><author><name sortKey="Homke, L" uniqKey="Homke L">L. Hömke</name></author><author><name sortKey="Schneider, F" uniqKey="Schneider F">F. Schneider</name></author><author><name sortKey="Habel, U" uniqKey="Habel U">U. Habel</name></author><author><name sortKey="Shah, N J" uniqKey="Shah N">N. J. Shah</name></author><author><name sortKey="Zilles, K" uniqKey="Zilles K">K. Zilles</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Powell, L E" uniqKey="Powell L">L. E. Powell</name></author><author><name sortKey="Myers, A M" uniqKey="Myers A">A. M. Myers</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Raz, N" uniqKey="Raz N">N. Raz</name></author><author><name sortKey="Rodrigue, K M" uniqKey="Rodrigue K">K. M. Rodrigue</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Regard, M" uniqKey="Regard M">M. Regard</name></author><author><name sortKey="Strauss, E" uniqKey="Strauss E">E. Strauss</name></author><author><name sortKey="Knapp, P" uniqKey="Knapp P">P. Knapp</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Reid, L M" uniqKey="Reid L">L. M. Reid</name></author><author><name sortKey="Maclullich, A M J" uniqKey="Maclullich A">A. M. J. MacLullich</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Reuter Lorenz, P A" uniqKey="Reuter Lorenz P">P. A. Reuter-Lorenz</name></author><author><name sortKey="Park, D C" uniqKey="Park D">D. C. Park</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Schelling, D" uniqKey="Schelling D">D. Schelling</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Schmermund, A" uniqKey="Schmermund A">A. Schmermund</name></author><author><name sortKey="Mohlenkamp, S" uniqKey="Mohlenkamp S">S. Möhlenkamp</name></author><author><name sortKey="Stang, A" uniqKey="Stang A">A. Stang</name></author><author><name sortKey="Gronemeyer, D" uniqKey="Gronemeyer D">D. Grönemeyer</name></author><author><name sortKey="Seibel, R" uniqKey="Seibel R">R. Seibel</name></author><author><name sortKey="Hirche, H" uniqKey="Hirche H">H. Hirche</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Schmidt, C O" uniqKey="Schmidt C">C. O. Schmidt</name></author><author><name sortKey="Hegenscheid, K" uniqKey="Hegenscheid K">K. Hegenscheid</name></author><author><name sortKey="Erdmann, P" uniqKey="Erdmann P">P. Erdmann</name></author><author><name sortKey="Kohlmann, T" uniqKey="Kohlmann T">T. Kohlmann</name></author><author><name sortKey="Langanke, M" uniqKey="Langanke M">M. Langanke</name></author><author><name sortKey="Volzke, H" uniqKey="Volzke H">H. Völzke</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Schmidt, K H" uniqKey="Schmidt K">K. H. Schmidt</name></author><author><name sortKey="Metzler, P" uniqKey="Metzler P">P. Metzler</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Seidler, R D" uniqKey="Seidler R">R. D. Seidler</name></author><author><name sortKey="Bernard, J A" uniqKey="Bernard J">J. A. Bernard</name></author><author><name sortKey="Burutolu, T B" uniqKey="Burutolu T">T. B. Burutolu</name></author><author><name sortKey="Fling, B W" uniqKey="Fling B">B. W. Fling</name></author><author><name sortKey="Gordon, M T" uniqKey="Gordon M">M. T. Gordon</name></author><author><name sortKey="Gwin, J T" uniqKey="Gwin J">J. T. Gwin</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Smith, S M" uniqKey="Smith S">S. M. Smith</name></author><author><name sortKey="Fox, P T" uniqKey="Fox P">P. T. Fox</name></author><author><name sortKey="Miller, K L" uniqKey="Miller K">K. L. Miller</name></author><author><name sortKey="Glahn, D C" uniqKey="Glahn D">D. C. Glahn</name></author><author><name sortKey="Fox, P M" uniqKey="Fox P">P. M. Fox</name></author><author><name sortKey="Mackay, C E" uniqKey="Mackay C">C. E. Mackay</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Spreng, R N" uniqKey="Spreng R">R. N. Spreng</name></author><author><name sortKey="Wojtowicz, M" uniqKey="Wojtowicz M">M. Wojtowicz</name></author><author><name sortKey="Grady, C L" uniqKey="Grady C">C. L. Grady</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Steffener, J" uniqKey="Steffener J">J. Steffener</name></author><author><name sortKey="Stern, Y" uniqKey="Stern Y">Y. Stern</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Stein, J L" uniqKey="Stein J">J. L. Stein</name></author><author><name sortKey="Medland, S E" uniqKey="Medland S">S. E. Medland</name></author><author><name sortKey="Vasquez, A A" uniqKey="Vasquez A">A. A. Vasquez</name></author><author><name sortKey="Hibar, D P" uniqKey="Hibar D">D. P. Hibar</name></author><author><name sortKey="Senstad, R E" uniqKey="Senstad R">R. E. Senstad</name></author><author><name sortKey="Winkler, A M" uniqKey="Winkler A">A. M. Winkler</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Stern, Y" uniqKey="Stern Y">Y. Stern</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Stern, Y" uniqKey="Stern Y">Y. Stern</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Stroop, J R" uniqKey="Stroop J">J. R. Stroop</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Sturm, W" uniqKey="Sturm W">W. Sturm</name></author><author><name sortKey="Willmes, K" uniqKey="Willmes K">K. Willmes</name></author><author><name sortKey="Horn, W" uniqKey="Horn W">W. Horn</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Sturma, D" uniqKey="Sturma D">D. Sturma</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Toga, A W" uniqKey="Toga A">A. W. Toga</name></author><author><name sortKey="Clark, K A" uniqKey="Clark K">K. A. Clark</name></author><author><name sortKey="Thompson, P M" uniqKey="Thompson P">P. M. Thompson</name></author><author><name sortKey="Shattuck, D W" uniqKey="Shattuck D">D. W. Shattuck</name></author><author><name sortKey="Van Horn, J D" uniqKey="Van Horn J">J. D. Van Horn</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Tucker, A M" uniqKey="Tucker A">A. M. Tucker</name></author><author><name sortKey="Stern, Y" uniqKey="Stern Y">Y. Stern</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Turner, G R" uniqKey="Turner G">G. R. Turner</name></author><author><name sortKey="Spreng, R N" uniqKey="Spreng R">R. N. Spreng</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Vaillant, G E" uniqKey="Vaillant G">G. E. Vaillant</name></author><author><name sortKey="Mukamal, K" uniqKey="Mukamal K">K. Mukamal</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Van Essen, D C" uniqKey="Van Essen D">D. C. Van Essen</name></author><author><name sortKey="Ugurbil, K" uniqKey="Ugurbil K">K. Ugurbil</name></author><author><name sortKey="Auerbach, E" uniqKey="Auerbach E">E. Auerbach</name></author><author><name sortKey="Barch, D" uniqKey="Barch D">D. Barch</name></author><author><name sortKey="Behrens, T E J" uniqKey="Behrens T">T. E. J. Behrens</name></author><author><name sortKey="Bucholz, R" uniqKey="Bucholz R">R. Bucholz</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Vernooij, M W" uniqKey="Vernooij M">M. W. Vernooij</name></author><author><name sortKey="Ikram, M A" uniqKey="Ikram M">M. A. Ikram</name></author><author><name sortKey="Tanghe, H L" uniqKey="Tanghe H">H. L. Tanghe</name></author><author><name sortKey="Vincent, A J" uniqKey="Vincent A">A. J. Vincent</name></author><author><name sortKey="Hofman, A" uniqKey="Hofman A">A. Hofman</name></author><author><name sortKey="Krestin, G P" uniqKey="Krestin G">G. P. Krestin</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Volzke, H" uniqKey="Volzke H">H. Völzke</name></author><author><name sortKey="Alte, D" uniqKey="Alte D">D. Alte</name></author><author><name sortKey="Schmidt, C O" uniqKey="Schmidt C">C. O. Schmidt</name></author><author><name sortKey="Radke, D" uniqKey="Radke D">D. Radke</name></author><author><name sortKey="Lorbeer, R" uniqKey="Lorbeer R">R. Lorbeer</name></author><author><name sortKey="Friedrich, N" uniqKey="Friedrich N">N. Friedrich</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Ward, N" uniqKey="Ward N">N. Ward</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Watt, D F" uniqKey="Watt D">D. F. Watt</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Weiner, M W" uniqKey="Weiner M">M. W. Weiner</name></author><author><name sortKey="Aisen, P S" uniqKey="Aisen P">P. S. Aisen</name></author><author><name sortKey="Jack, C R" uniqKey="Jack C">C. R. Jack</name></author><author><name sortKey="Jagust, W J" uniqKey="Jagust W">W. J. Jagust</name></author><author><name sortKey="Trojanowski, J Q" uniqKey="Trojanowski J">J. Q. Trojanowski</name></author><author><name sortKey="Shaw, L" uniqKey="Shaw L">L. Shaw</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Weiner, M W" uniqKey="Weiner M">M. W. Weiner</name></author><author><name sortKey="Veitch, D P" uniqKey="Veitch D">D. P. Veitch</name></author><author><name sortKey="Aisen, P S" uniqKey="Aisen P">P. S. Aisen</name></author><author><name sortKey="Beckett, L A" uniqKey="Beckett L">L. A. Beckett</name></author><author><name sortKey="Cairns, N J" uniqKey="Cairns N">N. J. Cairns</name></author><author><name sortKey="Green, R C" uniqKey="Green R">R. C. Green</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Wolf, S M" uniqKey="Wolf S">S. M. Wolf</name></author><author><name sortKey="Paradise, J" uniqKey="Paradise J">J. Paradise</name></author><author><name sortKey="Caga Anan, C" uniqKey="Caga Anan C">C. Caga-anan</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Zilles, K" uniqKey="Zilles K">K. Zilles</name></author><author><name sortKey="Amunts, K" uniqKey="Amunts K">K. Amunts</name></author></analytic></biblStruct></listBibl></div1></back></TEI><pmc article-type="research-article"><pmc-dir>properties open_access</pmc-dir>
<front><journal-meta><journal-id journal-id-type="nlm-ta">Front Aging Neurosci</journal-id><journal-id journal-id-type="iso-abbrev">Front Aging Neurosci</journal-id><journal-id journal-id-type="publisher-id">Front. Aging Neurosci.</journal-id><journal-title-group><journal-title>Frontiers in Aging Neuroscience</journal-title></journal-title-group><issn pub-type="epub">1663-4365</issn><publisher><publisher-name>Frontiers Media S.A.</publisher-name></publisher></journal-meta><article-meta><article-id pub-id-type="pmid">25071558</article-id><article-id pub-id-type="pmc">4094912</article-id><article-id pub-id-type="doi">10.3389/fnagi.2014.00149</article-id><article-categories><subj-group subj-group-type="heading"><subject>Neuroscience</subject><subj-group><subject>Methods Article</subject></subj-group></subj-group></article-categories><title-group><article-title>Studying variability in human brain aging in a population-based German cohort—rationale and design of 1000BRAINS</article-title></title-group><contrib-group><contrib contrib-type="author"><name><surname>Caspers</surname><given-names>Svenja</given-names></name><xref ref-type="aff" rid="aff1"><sup>1</sup></xref><xref ref-type="author-notes" rid="fn001"><sup>*</sup></xref><xref ref-type="author-notes" rid="fn003"><sup>†</sup></xref><uri xlink:type="simple" xlink:href="http://community.frontiersin.org/people/u/50089"></uri></contrib><contrib contrib-type="author"><name><surname>Moebus</surname><given-names>Susanne</given-names></name><xref ref-type="aff" rid="aff2"><sup>2</sup></xref><xref ref-type="author-notes" rid="fn003"><sup>†</sup></xref><uri xlink:type="simple" xlink:href="http://community.frontiersin.org/people/u/68892"></uri></contrib><contrib contrib-type="author"><name><surname>Lux</surname><given-names>Silke</given-names></name><xref ref-type="aff" rid="aff1"><sup>1</sup></xref><uri xlink:type="simple" xlink:href="http://community.frontiersin.org/people/u/168828"></uri></contrib><contrib contrib-type="author"><name><surname>Pundt</surname><given-names>Noreen</given-names></name><xref ref-type="aff" rid="aff2"><sup>2</sup></xref><uri xlink:type="simple" xlink:href="http://community.frontiersin.org/people/u/169276"></uri></contrib><contrib contrib-type="author"><name><surname>Schütz</surname><given-names>Holger</given-names></name><xref ref-type="aff" rid="aff1"><sup>1</sup></xref></contrib><contrib contrib-type="author"><name><surname>Mühleisen</surname><given-names>Thomas W.</given-names></name><xref ref-type="aff" rid="aff1"><sup>1</sup></xref><xref ref-type="aff" rid="aff3"><sup>3</sup></xref><xref ref-type="aff" rid="aff4"><sup>4</sup></xref><uri xlink:type="simple" xlink:href="http://community.frontiersin.org/people/u/139563"></uri></contrib><contrib contrib-type="author"><name><surname>Gras</surname><given-names>Vincent</given-names></name><xref ref-type="aff" rid="aff1"><sup>1</sup></xref><uri xlink:type="simple" xlink:href="http://community.frontiersin.org/people/u/154636"></uri></contrib><contrib contrib-type="author"><name><surname>Eickhoff</surname><given-names>Simon B.</given-names></name><xref ref-type="aff" rid="aff1"><sup>1</sup></xref><xref ref-type="aff" rid="aff5"><sup>5</sup></xref><uri xlink:type="simple" xlink:href="http://community.frontiersin.org/people/u/51828"></uri></contrib><contrib contrib-type="author"><name><surname>Romanzetti</surname><given-names>Sandro</given-names></name><xref ref-type="aff" rid="aff1"><sup>1</sup></xref><uri xlink:type="simple" xlink:href="http://community.frontiersin.org/people/u/119069"></uri></contrib><contrib contrib-type="author"><name><surname>Stöcker</surname><given-names>Tony</given-names></name><xref ref-type="aff" rid="aff1"><sup>1</sup></xref></contrib><contrib contrib-type="author"><name><surname>Stirnberg</surname><given-names>Rüdiger</given-names></name><xref ref-type="aff" rid="aff1"><sup>1</sup></xref><uri xlink:type="simple" xlink:href="http://community.frontiersin.org/people/u/171986"></uri></contrib><contrib contrib-type="author"><name><surname>Kirlangic</surname><given-names>Mehmet E.</given-names></name><xref ref-type="aff" rid="aff1"><sup>1</sup></xref><uri xlink:type="simple" xlink:href="http://community.frontiersin.org/people/u/170299"></uri></contrib><contrib contrib-type="author"><name><surname>Minnerop</surname><given-names>Martina</given-names></name><xref ref-type="aff" rid="aff1"><sup>1</sup></xref><uri xlink:type="simple" xlink:href="http://community.frontiersin.org/people/u/103410"></uri></contrib><contrib contrib-type="author"><name><surname>Pieperhoff</surname><given-names>Peter</given-names></name><xref ref-type="aff" rid="aff1"><sup>1</sup></xref><uri xlink:type="simple" xlink:href="http://community.frontiersin.org/people/u/109429"></uri></contrib><contrib contrib-type="author"><name><surname>Mödder</surname><given-names>Ulrich</given-names></name><xref ref-type="aff" rid="aff1"><sup>1</sup></xref></contrib><contrib contrib-type="author"><name><surname>Das</surname><given-names>Samir</given-names></name><xref ref-type="aff" rid="aff6"><sup>6</sup></xref><uri xlink:type="simple" xlink:href="http://community.frontiersin.org/people/u/35715"></uri></contrib><contrib contrib-type="author"><name><surname>Evans</surname><given-names>Alan C.</given-names></name><xref ref-type="aff" rid="aff6"><sup>6</sup></xref><uri xlink:type="simple" xlink:href="http://community.frontiersin.org/people/u/4918"></uri></contrib><contrib contrib-type="author"><name><surname>Jöckel</surname><given-names>Karl-Heinz</given-names></name><xref ref-type="aff" rid="aff2"><sup>2</sup></xref></contrib><contrib contrib-type="author"><name><surname>Erbel</surname><given-names>Raimund</given-names></name><xref ref-type="aff" rid="aff7"><sup>7</sup></xref></contrib><contrib contrib-type="author"><name><surname>Cichon</surname><given-names>Sven</given-names></name><xref ref-type="aff" rid="aff1"><sup>1</sup></xref><xref ref-type="aff" rid="aff3"><sup>3</sup></xref><xref ref-type="aff" rid="aff4"><sup>4</sup></xref><xref ref-type="aff" rid="aff8"><sup>8</sup></xref><uri xlink:type="simple" xlink:href="http://community.frontiersin.org/people/u/44429"></uri></contrib><contrib contrib-type="author"><name><surname>Nöthen</surname><given-names>Markus M.</given-names></name><xref ref-type="aff" rid="aff3"><sup>3</sup></xref><xref ref-type="aff" rid="aff4"><sup>4</sup></xref><uri xlink:type="simple" xlink:href="http://community.frontiersin.org/people/u/7014"></uri></contrib><contrib contrib-type="author"><name><surname>Sturma</surname><given-names>Dieter</given-names></name><xref ref-type="aff" rid="aff1"><sup>1</sup></xref><xref ref-type="aff" rid="aff9"><sup>9</sup></xref><uri xlink:type="simple" xlink:href="http://community.frontiersin.org/people/u/170560"></uri></contrib><contrib contrib-type="author"><name><surname>Bauer</surname><given-names>Andreas</given-names></name><xref ref-type="aff" rid="aff1"><sup>1</sup></xref><xref ref-type="aff" rid="aff10"><sup>10</sup></xref><uri xlink:type="simple" xlink:href="http://community.frontiersin.org/people/u/47977"></uri></contrib><contrib contrib-type="author"><name><surname>Jon Shah</surname><given-names>N.</given-names></name><xref ref-type="aff" rid="aff1"><sup>1</sup></xref><xref ref-type="aff" rid="aff11"><sup>11</sup></xref><xref ref-type="aff" rid="aff12"><sup>12</sup></xref><uri xlink:type="simple" xlink:href="http://community.frontiersin.org/people/u/115242"></uri></contrib><contrib contrib-type="author"><name><surname>Zilles</surname><given-names>Karl</given-names></name><xref ref-type="aff" rid="aff1"><sup>1</sup></xref><xref ref-type="aff" rid="aff11"><sup>11</sup></xref><xref ref-type="aff" rid="aff13"><sup>13</sup></xref><uri xlink:type="simple" xlink:href="http://community.frontiersin.org/people/u/2230"></uri></contrib><contrib contrib-type="author"><name><surname>Amunts</surname><given-names>Katrin</given-names></name><xref ref-type="aff" rid="aff1"><sup>1</sup></xref><xref ref-type="aff" rid="aff11"><sup>11</sup></xref><xref ref-type="aff" rid="aff14"><sup>14</sup></xref><uri xlink:type="simple" xlink:href="http://community.frontiersin.org/people/u/6448"></uri></contrib></contrib-group><aff id="aff1"><sup>1</sup><institution>Institute of Neuroscience and Medicine (INM-1, INM-2, INM-4, INM-8), Research Centre Jülich</institution><country>Jülich, Germany</country></aff><aff id="aff2"><sup>2</sup><institution>Institute of Medical Informatics, Biometry and Epidemiology, University of Duisburg-Essen</institution><country>Essen, Germany</country></aff><aff id="aff3"><sup>3</sup><institution>Department of Genomics, Life & Brain Center, University of Bonn</institution><country>Bonn, Germany</country></aff><aff id="aff4"><sup>4</sup><institution>Institute of Human Genetics, University of Bonn</institution><country>Bonn, Germany</country></aff><aff id="aff5"><sup>5</sup><institution>Institute for Clinical Neuroscience and Medical Psychology, University of Düsseldorf</institution><country>Düsseldorf, Germany</country></aff><aff id="aff6"><sup>6</sup><institution>McConnell Brain Imaging Center, Montreal Neurological Institute, McGill University</institution><country>Montreal, QC, Canada</country></aff><aff id="aff7"><sup>7</sup><institution>Department of Cardiology, University of Duisburg-Essen</institution><country>Essen, Germany</country></aff><aff id="aff8"><sup>8</sup><institution>Division of Medical Genetics, Department of Biomedicine, University of Basel</institution><country>Basel, Switzerland</country></aff><aff id="aff9"><sup>9</sup><institution>Institute for Science and Ethics, University of Bonn</institution><country>Bonn, Germany</country></aff><aff id="aff10"><sup>10</sup><institution>Department of Neurology, Heinrich-Heine-University Düsseldorf</institution><country>Düsseldorf, Germany</country></aff><aff id="aff11"><sup>11</sup><institution>JARA-BRAIN, Jülich-Aachen Research Alliance</institution><country>Jülich, Germany</country></aff><aff id="aff12"><sup>12</sup><institution>Department of Neurology, RWTH Aachen University</institution><country>Aachen, Germany</country></aff><aff id="aff13"><sup>13</sup><institution>Department of Psychiatry, Psychotherapy, and Psychosomatics, RWTH Aachen University</institution><country>Aachen, Germany</country></aff><aff id="aff14"><sup>14</sup><institution>C. and O. Vogt Institute for Brain Research, Heinrich-Heine-University Düsseldorf</institution><country>Düsseldorf, Germany</country></aff><author-notes><fn fn-type="edited-by"><p>Edited by: Rodrigo Orlando Kuljiš, Zdrav Mozak Limitada, Chile</p></fn><fn fn-type="edited-by"><p>Reviewed by: Stefano F. Cappa, Vita-Salute San Raffaele University, Italy; Douglas Watt, Quincy Medical Center, USA; Cambridge Health Alliance, USA</p></fn><corresp id="fn001">*Correspondence: Svenja Caspers, Research Centre Jülich, Institute of Neuroscience and Medicine (INM-1), Leo-Brandt-Str. 2, 52425 Jülich, Germany e-mail: <email xlink:type="simple">s.caspers@fz-juelich.de</email></corresp><fn fn-type="other" id="fn002"><p>This article was submitted to the journal Frontiers in Aging Neuroscience.</p></fn><fn fn-type="present-address" id="fn003"><p>†These authors have contributed equally to this work.</p></fn></author-notes><pub-date pub-type="epub"><day>14</day><month>7</month><year>2014</year></pub-date><pub-date pub-type="collection"><year>2014</year></pub-date><volume>6</volume><elocation-id>149</elocation-id><history><date date-type="received"><day>21</day><month>2</month><year>2014</year></date><date date-type="accepted"><day>17</day><month>6</month><year>2014</year></date></history><permissions><copyright-statement>Copyright © 2014 Caspers, Moebus, Lux, Pundt, Schütz, Mühleisen, Gras, Eickhoff, Romanzetti, Stöcker, Stirnberg, Kirlangic, Minnerop, Pieperhoff, Mödder, Das, Evans, Jöckel, Erbel, Cichon, Nöthen, Sturma, Bauer, Jon Shah, Zilles and Amunts.</copyright-statement><copyright-year>2014</copyright-year><license license-type="open-access" xlink:href="http://creativecommons.org/licenses/by/3.0/"><license-p>This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.</license-p></license></permissions><abstract><p>The ongoing 1000 brains study (1000BRAINS) is an epidemiological and neuroscientific investigation of structural and functional variability in the human brain during aging. The two recruitment sources are the 10-year follow-up cohort of the German Heinz Nixdorf Recall (HNR) Study, and the HNR MultiGeneration Study cohort, which comprises spouses and offspring of HNR subjects. The HNR is a longitudinal epidemiological investigation of cardiovascular risk factors, with a comprehensive collection of clinical, laboratory, socioeconomic, and environmental data from population-based subjects aged 45–75 years on inclusion. HNR subjects underwent detailed assessments in 2000, 2006, and 2011, and completed annual postal questionnaires on health status. 1000BRAINS accesses these HNR data and applies a separate protocol comprising: neuropsychological tests of attention, memory, executive functions and language; examination of motor skills; ratings of personality, life quality, mood and daily activities; analysis of laboratory and genetic data; and state-of-the-art magnetic resonance imaging (MRI, 3 Tesla) of the brain. The latter includes (i) 3D-T1- and 3D-T2-weighted scans for structural analyses and myelin mapping; (ii) three diffusion imaging sequences optimized for diffusion tensor imaging, high-angular resolution diffusion imaging for detailed fiber tracking and for diffusion kurtosis imaging; (iii) resting-state and task-based functional MRI; and (iv) fluid-attenuated inversion recovery and MR angiography for the detection of vascular lesions and the mapping of white matter lesions. The unique design of 1000BRAINS allows: (i) comprehensive investigation of various influences including genetics, environment and health status on variability in brain structure and function during aging; and (ii) identification of the impact of selected influencing factors on specific cognitive subsystems and their anatomical correlates.</p></abstract><kwd-group><kwd>cohort</kwd><kwd>connectivity</kwd><kwd>Heinz Nixdorf Recall Study</kwd><kwd>resting-state</kwd><kwd>imaging genetics</kwd><kwd>variability</kwd><kwd>aging</kwd><kwd>elderly</kwd></kwd-group><counts><fig-count count="4"></fig-count><table-count count="4"></table-count><equation-count count="0"></equation-count><ref-count count="108"></ref-count><page-count count="14"></page-count><word-count count="11031"></word-count></counts></article-meta></front></pmc><affiliations><list><country><li>Allemagne</li><li>Canada</li><li>Suisse</li></country></list><tree><country name="Allemagne"><noRegion><name sortKey="Caspers, Svenja" sort="Caspers, Svenja" uniqKey="Caspers S" first="Svenja" last="Caspers">Svenja Caspers</name></noRegion><name sortKey="Amunts, Katrin" sort="Amunts, Katrin" uniqKey="Amunts K" first="Katrin" last="Amunts">Katrin Amunts</name><name sortKey="Amunts, Katrin" sort="Amunts, Katrin" uniqKey="Amunts K" first="Katrin" last="Amunts">Katrin Amunts</name><name sortKey="Amunts, Katrin" sort="Amunts, Katrin" uniqKey="Amunts K" first="Katrin" last="Amunts">Katrin Amunts</name><name sortKey="Bauer, Andreas" sort="Bauer, Andreas" uniqKey="Bauer A" first="Andreas" last="Bauer">Andreas Bauer</name><name sortKey="Bauer, Andreas" sort="Bauer, Andreas" uniqKey="Bauer A" first="Andreas" last="Bauer">Andreas Bauer</name><name sortKey="Cichon, Sven" sort="Cichon, Sven" uniqKey="Cichon S" first="Sven" last="Cichon">Sven Cichon</name><name sortKey="Cichon, Sven" sort="Cichon, Sven" uniqKey="Cichon S" first="Sven" last="Cichon">Sven Cichon</name><name sortKey="Cichon, Sven" sort="Cichon, Sven" uniqKey="Cichon S" first="Sven" last="Cichon">Sven Cichon</name><name sortKey="Eickhoff, Simon B" sort="Eickhoff, Simon B" uniqKey="Eickhoff S" first="Simon B." last="Eickhoff">Simon B. Eickhoff</name><name sortKey="Eickhoff, Simon B" sort="Eickhoff, Simon B" uniqKey="Eickhoff S" first="Simon B." last="Eickhoff">Simon B. Eickhoff</name><name sortKey="Erbel, Raimund" sort="Erbel, Raimund" uniqKey="Erbel R" first="Raimund" last="Erbel">Raimund Erbel</name><name sortKey="Gras, Vincent" sort="Gras, Vincent" uniqKey="Gras V" first="Vincent" last="Gras">Vincent Gras</name><name sortKey="Jockel, Karl Heinz" sort="Jockel, Karl Heinz" uniqKey="Jockel K" first="Karl-Heinz" last="Jöckel">Karl-Heinz Jöckel</name><name sortKey="Jon Shah, N" sort="Jon Shah, N" uniqKey="Jon Shah N" first="N." last="Jon Shah">N. Jon Shah</name><name sortKey="Jon Shah, N" sort="Jon Shah, N" uniqKey="Jon Shah N" first="N." last="Jon Shah">N. Jon Shah</name><name sortKey="Jon Shah, N" sort="Jon Shah, N" uniqKey="Jon Shah N" first="N." last="Jon Shah">N. Jon Shah</name><name sortKey="Kirlangic, Mehmet E" sort="Kirlangic, Mehmet E" uniqKey="Kirlangic M" first="Mehmet E." last="Kirlangic">Mehmet E. Kirlangic</name><name sortKey="Lux, Silke" sort="Lux, Silke" uniqKey="Lux S" first="Silke" last="Lux">Silke Lux</name><name sortKey="Minnerop, Martina" sort="Minnerop, Martina" uniqKey="Minnerop M" first="Martina" last="Minnerop">Martina Minnerop</name><name sortKey="Modder, Ulrich" sort="Modder, Ulrich" uniqKey="Modder U" first="Ulrich" last="Mödder">Ulrich Mödder</name><name sortKey="Moebus, Susanne" sort="Moebus, Susanne" uniqKey="Moebus S" first="Susanne" last="Moebus">Susanne Moebus</name><name sortKey="Muhleisen, Thomas W" sort="Muhleisen, Thomas W" uniqKey="Muhleisen T" first="Thomas W." last="Mühleisen">Thomas W. Mühleisen</name><name sortKey="Muhleisen, Thomas W" sort="Muhleisen, Thomas W" uniqKey="Muhleisen T" first="Thomas W." last="Mühleisen">Thomas W. Mühleisen</name><name sortKey="Muhleisen, Thomas W" sort="Muhleisen, Thomas W" uniqKey="Muhleisen T" first="Thomas W." last="Mühleisen">Thomas W. Mühleisen</name><name sortKey="Nothen, Markus M" sort="Nothen, Markus M" uniqKey="Nothen M" first="Markus M." last="Nöthen">Markus M. Nöthen</name><name sortKey="Nothen, Markus M" sort="Nothen, Markus M" uniqKey="Nothen M" first="Markus M." last="Nöthen">Markus M. Nöthen</name><name sortKey="Pieperhoff, Peter" sort="Pieperhoff, Peter" uniqKey="Pieperhoff P" first="Peter" last="Pieperhoff">Peter Pieperhoff</name><name sortKey="Pundt, Noreen" sort="Pundt, Noreen" uniqKey="Pundt N" first="Noreen" last="Pundt">Noreen Pundt</name><name sortKey="Romanzetti, Sandro" sort="Romanzetti, Sandro" uniqKey="Romanzetti S" first="Sandro" last="Romanzetti">Sandro Romanzetti</name><name sortKey="Schutz, Holger" sort="Schutz, Holger" uniqKey="Schutz H" first="Holger" last="Schütz">Holger Schütz</name><name sortKey="Stirnberg, Rudiger" sort="Stirnberg, Rudiger" uniqKey="Stirnberg R" first="Rüdiger" last="Stirnberg">Rüdiger Stirnberg</name><name sortKey="Stocker, Tony" sort="Stocker, Tony" uniqKey="Stocker T" first="Tony" last="Stöcker">Tony Stöcker</name><name sortKey="Sturma, Dieter" sort="Sturma, Dieter" uniqKey="Sturma D" first="Dieter" last="Sturma">Dieter Sturma</name><name sortKey="Sturma, Dieter" sort="Sturma, Dieter" uniqKey="Sturma D" first="Dieter" last="Sturma">Dieter Sturma</name><name sortKey="Zilles, Karl" sort="Zilles, Karl" uniqKey="Zilles K" first="Karl" last="Zilles">Karl Zilles</name><name sortKey="Zilles, Karl" sort="Zilles, Karl" uniqKey="Zilles K" first="Karl" last="Zilles">Karl Zilles</name><name sortKey="Zilles, Karl" sort="Zilles, Karl" uniqKey="Zilles K" first="Karl" last="Zilles">Karl Zilles</name></country><country name="Canada"><noRegion><name sortKey="Das, Samir" sort="Das, Samir" uniqKey="Das S" first="Samir" last="Das">Samir Das</name></noRegion><name sortKey="Evans, Alan C" sort="Evans, Alan C" uniqKey="Evans A" first="Alan C." last="Evans">Alan C. Evans</name></country><country name="Suisse"><noRegion><name sortKey="Cichon, Sven" sort="Cichon, Sven" uniqKey="Cichon S" first="Sven" last="Cichon">Sven Cichon</name></noRegion></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
EXPLOR_STEP=$WICRI_ROOT/Wicri/Canada/explor/ParkinsonCanadaV1/Data/Pmc/Checkpoint
HfdSelect -h $EXPLOR_STEP/biblio.hfd -nk 000409 | SxmlIndent | more
Ou
HfdSelect -h $EXPLOR_AREA/Data/Pmc/Checkpoint/biblio.hfd -nk 000409 | SxmlIndent | more
Pour mettre un lien sur cette page dans le réseau Wicri
{{Explor lien
|wiki= Wicri/Canada
|area= ParkinsonCanadaV1
|flux= Pmc
|étape= Checkpoint
|type= RBID
|clé= PMC:4094912
|texte= Studying variability in human brain aging in a population-based German cohort—rationale and design of 1000BRAINS
}}
Pour générer des pages wiki
HfdIndexSelect -h $EXPLOR_AREA/Data/Pmc/Checkpoint/RBID.i -Sk "pubmed:25071558" \
| HfdSelect -Kh $EXPLOR_AREA/Data/Pmc/Checkpoint/biblio.hfd \
| NlmPubMed2Wicri -a ParkinsonCanadaV1
| This area was generated with Dilib version V0.6.29. |  |