ParkinsonCanadaV1, Pmc, Checkpoint, bibRecord, 000242

PINK1 deficiency enhances autophagy and mitophagy induction

Identifieur interne : 000242 ( Pmc/Checkpoint ); précédent : 000241; suivant : 000243

PINK1 deficiency enhances autophagy and mitophagy induction

Auteurs : Rubén G Mez-Sánchez [Espagne] ; Sokhna M S. Yakhine-Diop [Espagne] ; José M. Bravo-San Pedro [Espagne, France] ; Elisa Pizarro-Estrella [Espagne] ; Mario Rodríguez-Arribas [Espagne] ; Vicente Climent [Espagne] ; Francisco E. Martin-Cano [Espagne] ; María E. González-Soltero [Espagne] ; Anurag Tandon [Canada] ; José M. Fuentes [Espagne] ; Rosa A. González-Polo [Espagne]

Source :

Molecular & Cellular Oncology [ 2372-3548 ] ; 2015.

RBID : PMC:4905358

Abstract

Parkinson's disease (PD) is a neurodegenerative disorder with poorly understood etiology. Increasing evidence suggests that age-dependent compromise of the maintenance of mitochondrial function is a key risk factor. Several proteins encoded by PD-related genes are associated with mitochondria including PTEN-induced putative kinase 1 (PINK1), which was first identified as a gene that is upregulated by PTEN. Loss-of-function PINK1 mutations induce mitochondrial dysfunction and, ultimately, neuronal cell death. To mitigate the negative effects of altered cellular functions cells possess a degradation mechanism called autophagy for recycling damaged components; selective elimination of dysfunctional mitochondria by autophagy is termed mitophagy. Our study indicates that autophagy and mitophagy are upregulated in PINK1-deficient cells, and is the first report to demonstrate efficient fluxes by one-step analysis. We propose that autophagy is induced to maintain cellular homeostasis under conditions of non-regulated mitochondrial quality control.

Url:

http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4905358

DOI: 10.1080/23723556.2015.1046579
PubMed: 27308585
PubMed Central: 4905358

Affiliations:

Canada, Espagne, France

Links toward previous steps (curation, corpus...)

to stream Pmc, to step Corpus: 000126
to stream Pmc, to step Curation: 000126

Links to Exploration step

PMC:4905358

Le document en format XML

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<country xml:lang="fr">Espagne</country>
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<author><name sortKey="Yakhine Diop, Sokhna M S" sort="Yakhine Diop, Sokhna M S" uniqKey="Yakhine Diop S" first="Sokhna M S" last="Yakhine-Diop">Sokhna M S. Yakhine-Diop</name>
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<author><name sortKey="Martin Cano, Francisco E" sort="Martin Cano, Francisco E" uniqKey="Martin Cano F" first="Francisco E" last="Martin-Cano">Francisco E. Martin-Cano</name>
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<country xml:lang="fr">Espagne</country>
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<author><name sortKey="Gonzalez Soltero, Maria E" sort="Gonzalez Soltero, Maria E" uniqKey="Gonzalez Soltero M" first="María E" last="González-Soltero">María E. González-Soltero</name>
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; Plasencia,<country>Spain</country>
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<country xml:lang="fr">Espagne</country>
<wicri:regionArea># see nlm:aff country strict</wicri:regionArea>
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<author><name sortKey="Tandon, Anurag" sort="Tandon, Anurag" uniqKey="Tandon A" first="Anurag" last="Tandon">Anurag Tandon</name>
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<wicri:regionArea># see nlm:aff country strict</wicri:regionArea>
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<country xml:lang="fr">Espagne</country>
<wicri:regionArea># see nlm:aff country strict</wicri:regionArea>
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<affiliation><nlm:aff id="af0010">These authors contributed equally to this work.</nlm:aff>
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<author><name sortKey="Gonzalez Polo, Rosa A" sort="Gonzalez Polo, Rosa A" uniqKey="Gonzalez Polo R" first="Rosa A" last="González-Polo">Rosa A. González-Polo</name>
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</nlm:aff>
<country xml:lang="fr">Espagne</country>
<wicri:regionArea># see nlm:aff country strict</wicri:regionArea>
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<affiliation><nlm:aff id="af0010">These authors contributed equally to this work.</nlm:aff>
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<sourceDesc><biblStruct><analytic><title xml:lang="en" level="a" type="main">PINK1 deficiency enhances autophagy and mitophagy induction</title>
<author><name sortKey="G Mez Sanchez, Ruben" sort="G Mez Sanchez, Ruben" uniqKey="G Mez Sanchez R" first="Rubén" last="G Mez-Sánchez">Rubén G Mez-Sánchez</name>
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<author><name sortKey="Yakhine Diop, Sokhna M S" sort="Yakhine Diop, Sokhna M S" uniqKey="Yakhine Diop S" first="Sokhna M S" last="Yakhine-Diop">Sokhna M S. Yakhine-Diop</name>
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<wicri:regionArea># see nlm:aff country strict</wicri:regionArea>
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; Paris,<country>France</country>
</nlm:aff>
<country xml:lang="fr">France</country>
<wicri:regionArea># see nlm:aff country strict</wicri:regionArea>
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<wicri:regionArea># see nlm:aff country strict</wicri:regionArea>
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<country xml:lang="fr">France</country>
<wicri:regionArea># see nlm:aff country strict</wicri:regionArea>
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<author><name sortKey="Pizarro Estrella, Elisa" sort="Pizarro Estrella, Elisa" uniqKey="Pizarro Estrella E" first="Elisa" last="Pizarro-Estrella">Elisa Pizarro-Estrella</name>
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; Cáceres,<country>Spain</country>
</nlm:aff>
<country xml:lang="fr">Espagne</country>
<wicri:regionArea># see nlm:aff country strict</wicri:regionArea>
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<author><name sortKey="Rodriguez Arribas, Mario" sort="Rodriguez Arribas, Mario" uniqKey="Rodriguez Arribas M" first="Mario" last="Rodríguez-Arribas">Mario Rodríguez-Arribas</name>
<affiliation wicri:level="1"><nlm:aff id="af0001"><institution>Centro de Investigación Biomédica en Red sobre Enfermedades Neurodegenerativas; Departamento de Bioquímica y Biología Molecular y Genética; Universidad de Extremadura; Facultad de Enfermería y Terapia Ocupacional</institution>
; Cáceres,<country>Spain</country>
</nlm:aff>
<country xml:lang="fr">Espagne</country>
<wicri:regionArea># see nlm:aff country strict</wicri:regionArea>
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<author><name sortKey="Climent, Vicente" sort="Climent, Vicente" uniqKey="Climent V" first="Vicente" last="Climent">Vicente Climent</name>
<affiliation wicri:level="1"><nlm:aff id="af0006"><institution>Departamento de Anatomía y Embriología Humana; Facultad de Medicina; Universidad de Extremadura</institution>
; Badajoz,<country>Spain</country>
</nlm:aff>
<country xml:lang="fr">Espagne</country>
<wicri:regionArea># see nlm:aff country strict</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Martin Cano, Francisco E" sort="Martin Cano, Francisco E" uniqKey="Martin Cano F" first="Francisco E" last="Martin-Cano">Francisco E. Martin-Cano</name>
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; Cáceres,<country>Spain</country>
</nlm:aff>
<country xml:lang="fr">Espagne</country>
<wicri:regionArea># see nlm:aff country strict</wicri:regionArea>
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<author><name sortKey="Gonzalez Soltero, Maria E" sort="Gonzalez Soltero, Maria E" uniqKey="Gonzalez Soltero M" first="María E" last="González-Soltero">María E. González-Soltero</name>
<affiliation wicri:level="1"><nlm:aff id="af0008"><institution>Sección de Neurología; Hospital Virgen del Puerto</institution>
; Plasencia,<country>Spain</country>
</nlm:aff>
<country xml:lang="fr">Espagne</country>
<wicri:regionArea># see nlm:aff country strict</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Tandon, Anurag" sort="Tandon, Anurag" uniqKey="Tandon A" first="Anurag" last="Tandon">Anurag Tandon</name>
<affiliation wicri:level="1"><nlm:aff id="af0009"><institution>Tanz Center for Research in Neurodegenerative Diseases; University of Toronto</institution>
; Toronto, ON<country>Canada</country>
</nlm:aff>
<country xml:lang="fr">Canada</country>
<wicri:regionArea># see nlm:aff country strict</wicri:regionArea>
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<author><name sortKey="Fuentes, Jose M" sort="Fuentes, Jose M" uniqKey="Fuentes J" first="José M" last="Fuentes">José M. Fuentes</name>
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; Cáceres,<country>Spain</country>
</nlm:aff>
<country xml:lang="fr">Espagne</country>
<wicri:regionArea># see nlm:aff country strict</wicri:regionArea>
</affiliation>
<affiliation><nlm:aff id="af0010">These authors contributed equally to this work.</nlm:aff>
</affiliation>
</author>
<author><name sortKey="Gonzalez Polo, Rosa A" sort="Gonzalez Polo, Rosa A" uniqKey="Gonzalez Polo R" first="Rosa A" last="González-Polo">Rosa A. González-Polo</name>
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</nlm:aff>
<country xml:lang="fr">Espagne</country>
<wicri:regionArea># see nlm:aff country strict</wicri:regionArea>
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<affiliation><nlm:aff id="af0010">These authors contributed equally to this work.</nlm:aff>
</affiliation>
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<idno type="ISSN">2372-3548</idno>
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<front><div type="abstract" xml:lang="en"><p>Parkinson's disease (PD) is a neurodegenerative disorder with poorly understood etiology. Increasing evidence suggests that age-dependent compromise of the maintenance of mitochondrial function is a key risk factor. Several proteins encoded by PD-related genes are associated with mitochondria including <italic>PTEN-induced putative kinase 1</italic>
 (<italic>PINK1</italic>
), which was first identified as a gene that is upregulated by PTEN. Loss-of-function <italic>PINK1</italic>
 mutations induce mitochondrial dysfunction and, ultimately, neuronal cell death. To mitigate the negative effects of altered cellular functions cells possess a degradation mechanism called autophagy for recycling damaged components; selective elimination of dysfunctional mitochondria by autophagy is termed mitophagy. Our study indicates that autophagy and mitophagy are upregulated in <italic>PINK1</italic>
-deficient cells, and is the first report to demonstrate efficient fluxes by one-step analysis. We propose that autophagy is induced to maintain cellular homeostasis under conditions of non-regulated mitochondrial quality control.</p>
</div>
</front>
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<pmc article-type="research-article"><pmc-comment>The publisher of this article does not allow downloading of the full text in XML form.</pmc-comment>
  <front><journal-meta><journal-id journal-id-type="nlm-ta">Mol Cell Oncol</journal-id>
<journal-id journal-id-type="iso-abbrev">Mol Cell Oncol</journal-id>
<journal-id journal-id-type="pmc">KMCO</journal-id>
<journal-title-group><journal-title>Molecular & Cellular Oncology</journal-title>
</journal-title-group>
<issn pub-type="ppub">2372-3548</issn>
<issn pub-type="epub">2372-3556</issn>
<publisher><publisher-name>Taylor & Francis</publisher-name>
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<article-id pub-id-type="doi">10.1080/23723556.2015.1046579</article-id>
<article-categories><subj-group subj-group-type="heading"><subject>Research Paper</subject>
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<title-group><article-title>PINK1 deficiency enhances autophagy and mitophagy induction</article-title>
</title-group>
<contrib-group><contrib contrib-type="author"><name><surname>Gómez-Sánchez</surname>
<given-names>Rubén</given-names>
</name>
<xref ref-type="aff" rid="af0001"><sup>1</sup>
</xref>
</contrib>
<contrib contrib-type="author"><name><surname>Yakhine-Diop</surname>
<given-names>Sokhna M S</given-names>
</name>
<xref ref-type="aff" rid="af0001"><sup>1</sup>
</xref>
</contrib>
<contrib contrib-type="author"><name><surname>Bravo-San Pedro</surname>
<given-names>José M</given-names>
</name>
<xref ref-type="aff" rid="af0001"><sup>1</sup>
</xref>
<xref ref-type="aff" rid="af0002"><sup>2</sup>
</xref>
<xref ref-type="aff" rid="af0003"><sup>3</sup>
</xref>
<xref ref-type="aff" rid="af0004"><sup>4</sup>
</xref>
<xref ref-type="aff" rid="af0005"><sup>5</sup>
</xref>
</contrib>
<contrib contrib-type="author"><name><surname>Pizarro-Estrella</surname>
<given-names>Elisa</given-names>
</name>
<xref ref-type="aff" rid="af0001"><sup>1</sup>
</xref>
</contrib>
<contrib contrib-type="author"><name><surname>Rodríguez-Arribas</surname>
<given-names>Mario</given-names>
</name>
<xref ref-type="aff" rid="af0001"><sup>1</sup>
</xref>
</contrib>
<contrib contrib-type="author"><name><surname>Climent</surname>
<given-names>Vicente</given-names>
</name>
<xref ref-type="aff" rid="af0006"><sup>6</sup>
</xref>
</contrib>
<contrib contrib-type="author"><name><surname>Martin-Cano</surname>
<given-names>Francisco E</given-names>
</name>
<xref ref-type="aff" rid="af0007"><sup>7</sup>
</xref>
</contrib>
<contrib contrib-type="author"><name><surname>González-Soltero</surname>
<given-names>María E</given-names>
</name>
<xref ref-type="aff" rid="af0008"><sup>8</sup>
</xref>
</contrib>
<contrib contrib-type="author"><name><surname>Tandon</surname>
<given-names>Anurag</given-names>
</name>
<xref ref-type="aff" rid="af0009"><sup>9</sup>
</xref>
</contrib>
<contrib contrib-type="author"><name><surname>Fuentes</surname>
<given-names>José M</given-names>
</name>
<xref ref-type="aff" rid="af0001"><sup>1</sup>
</xref>
<xref ref-type="aff" rid="af0010"><sup>†</sup>
</xref>
<xref ref-type="corresp" rid="an0001"><sup>*</sup>
</xref>
</contrib>
<contrib contrib-type="author"><name><surname>González-Polo</surname>
<given-names>Rosa A</given-names>
</name>
<xref ref-type="aff" rid="af0001"><sup>1</sup>
</xref>
<xref ref-type="aff" rid="af0010"><sup>†</sup>
</xref>
</contrib>
<aff id="af0001"><label>1</label>
<institution>Centro de Investigación Biomédica en Red sobre Enfermedades Neurodegenerativas; Departamento de Bioquímica y Biología Molecular y Genética; Universidad de Extremadura; Facultad de Enfermería y Terapia Ocupacional</institution>
; Cáceres,<country>Spain</country>
</aff>
<aff id="af0002"><label>2</label>
<institution>Equipe 11 Labellisee pas la Ligue Nationale Contre le Cancer; Center de Recherche des Cordeliers</institution>
; Paris,<country>France</country>
</aff>
<aff id="af0003"><label>3</label>
<institution>Sorbonne Paris Cite</institution>
; Paris,<country>France</country>
</aff>
<aff id="af0004"><label>4</label>
<institution>Gustave Roussy Cancer Campus</institution>
; Villejuif,<country>France</country>
</aff>
<aff id="af0005"><label>5</label>
<institution>Metabolomics and Cell Biology Platforms; Gustave Roussy Cancer Campus</institution>
; Villejuif,<country>France</country>
</aff>
<aff id="af0006"><label>6</label>
<institution>Departamento de Anatomía y Embriología Humana; Facultad de Medicina; Universidad de Extremadura</institution>
; Badajoz,<country>Spain</country>
</aff>
<aff id="af0007"><label>7</label>
<institution>Departamento de Fisiología; Facultad de Enfermería y Terapia Ocupacional; Universidad de Extremadura</institution>
; Cáceres,<country>Spain</country>
</aff>
<aff id="af0008"><label>8</label>
<institution>Sección de Neurología; Hospital Virgen del Puerto</institution>
; Plasencia,<country>Spain</country>
</aff>
<aff id="af0009"><label>9</label>
<institution>Tanz Center for Research in Neurodegenerative Diseases; University of Toronto</institution>
; Toronto, ON<country>Canada</country>
</aff>
<aff id="af0010"><label>†</label>
These authors contributed equally to this work.</aff>
</contrib-group>
<author-notes><corresp id="an0001"><label>*</label>
Correspondence to: José M Fuentes; Email: <email xlink:href="jfuentes@unex.es">jfuentes@unex.es</email>
</corresp>
</author-notes>
<pub-date pub-type="collection"><month>3</month>
<year>2016</year>
</pub-date>
<pub-date pub-type="epub"><day>20</day>
<month>8</month>
<year>2015</year>
</pub-date>
<volume>3</volume>
<issue>2</issue>
<elocation-id seq="52">e1046579</elocation-id>
<history><date date-type="received"><day>15</day>
<month>3</month>
<year>2015</year>
</date>
<date date-type="rev-recd"><day>23</day>
<month>4</month>
<year>2015</year>
</date>
<date date-type="accepted"><day>23</day>
<month>4</month>
<year>2015</year>
</date>
</history>
<permissions><copyright-statement>© 2016 Taylor & Francis Group, LLC</copyright-statement>
<copyright-year>2016</copyright-year>
<copyright-holder>Taylor & Francis Group, LLC</copyright-holder>
</permissions>
<self-uri content-type="pdf" xlink:href="kmco-03-02-1046579.pdf"></self-uri>
<abstract><p>Parkinson's disease (PD) is a neurodegenerative disorder with poorly understood etiology. Increasing evidence suggests that age-dependent compromise of the maintenance of mitochondrial function is a key risk factor. Several proteins encoded by PD-related genes are associated with mitochondria including <italic>PTEN-induced putative kinase 1</italic>
 (<italic>PINK1</italic>
), which was first identified as a gene that is upregulated by PTEN. Loss-of-function <italic>PINK1</italic>
 mutations induce mitochondrial dysfunction and, ultimately, neuronal cell death. To mitigate the negative effects of altered cellular functions cells possess a degradation mechanism called autophagy for recycling damaged components; selective elimination of dysfunctional mitochondria by autophagy is termed mitophagy. Our study indicates that autophagy and mitophagy are upregulated in <italic>PINK1</italic>
-deficient cells, and is the first report to demonstrate efficient fluxes by one-step analysis. We propose that autophagy is induced to maintain cellular homeostasis under conditions of non-regulated mitochondrial quality control.</p>
</abstract>
<kwd-group kwd-group-type="author"><title>Keywords</title>
<kwd>autophagy</kwd>
<kwd>cancer</kwd>
<kwd>mitochondria</kwd>
<kwd>mitophagy</kwd>
<kwd>Parkinson's disease</kwd>
<kwd>PINK1</kwd>
</kwd-group>
<counts><fig-count count="5"></fig-count>
<table-count count="0"></table-count>
<ref-count count="52"></ref-count>
<page-count count="10"></page-count>
</counts>
</article-meta>
</front>
</pmc>
<affiliations><list><country><li>Canada</li>
<li>Espagne</li>
<li>France</li>
</country>
</list>
<tree><country name="Espagne"><noRegion><name sortKey="G Mez Sanchez, Ruben" sort="G Mez Sanchez, Ruben" uniqKey="G Mez Sanchez R" first="Rubén" last="G Mez-Sánchez">Rubén G Mez-Sánchez</name>
</noRegion>
<name sortKey="Bravo San Pedro, Jose M" sort="Bravo San Pedro, Jose M" uniqKey="Bravo San Pedro J" first="José M" last="Bravo-San Pedro">José M. Bravo-San Pedro</name>
<name sortKey="Climent, Vicente" sort="Climent, Vicente" uniqKey="Climent V" first="Vicente" last="Climent">Vicente Climent</name>
<name sortKey="Fuentes, Jose M" sort="Fuentes, Jose M" uniqKey="Fuentes J" first="José M" last="Fuentes">José M. Fuentes</name>
<name sortKey="Gonzalez Polo, Rosa A" sort="Gonzalez Polo, Rosa A" uniqKey="Gonzalez Polo R" first="Rosa A" last="González-Polo">Rosa A. González-Polo</name>
<name sortKey="Gonzalez Soltero, Maria E" sort="Gonzalez Soltero, Maria E" uniqKey="Gonzalez Soltero M" first="María E" last="González-Soltero">María E. González-Soltero</name>
<name sortKey="Martin Cano, Francisco E" sort="Martin Cano, Francisco E" uniqKey="Martin Cano F" first="Francisco E" last="Martin-Cano">Francisco E. Martin-Cano</name>
<name sortKey="Pizarro Estrella, Elisa" sort="Pizarro Estrella, Elisa" uniqKey="Pizarro Estrella E" first="Elisa" last="Pizarro-Estrella">Elisa Pizarro-Estrella</name>
<name sortKey="Rodriguez Arribas, Mario" sort="Rodriguez Arribas, Mario" uniqKey="Rodriguez Arribas M" first="Mario" last="Rodríguez-Arribas">Mario Rodríguez-Arribas</name>
<name sortKey="Yakhine Diop, Sokhna M S" sort="Yakhine Diop, Sokhna M S" uniqKey="Yakhine Diop S" first="Sokhna M S" last="Yakhine-Diop">Sokhna M S. Yakhine-Diop</name>
</country>
<country name="France"><noRegion><name sortKey="Bravo San Pedro, Jose M" sort="Bravo San Pedro, Jose M" uniqKey="Bravo San Pedro J" first="José M" last="Bravo-San Pedro">José M. Bravo-San Pedro</name>
</noRegion>
<name sortKey="Bravo San Pedro, Jose M" sort="Bravo San Pedro, Jose M" uniqKey="Bravo San Pedro J" first="José M" last="Bravo-San Pedro">José M. Bravo-San Pedro</name>
<name sortKey="Bravo San Pedro, Jose M" sort="Bravo San Pedro, Jose M" uniqKey="Bravo San Pedro J" first="José M" last="Bravo-San Pedro">José M. Bravo-San Pedro</name>
<name sortKey="Bravo San Pedro, Jose M" sort="Bravo San Pedro, Jose M" uniqKey="Bravo San Pedro J" first="José M" last="Bravo-San Pedro">José M. Bravo-San Pedro</name>
</country>
<country name="Canada"><noRegion><name sortKey="Tandon, Anurag" sort="Tandon, Anurag" uniqKey="Tandon A" first="Anurag" last="Tandon">Anurag Tandon</name>
</noRegion>
</country>
</tree>
</affiliations>
</record>

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	La maladie de Parkinson au Canada (serveur d'exploration)
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La maladie de Parkinson au Canada (serveur d'exploration)

PINK1 deficiency enhances autophagy and mitophagy induction

PINK1 deficiency enhances autophagy and mitophagy induction

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