Sleep spindle alterations in patients with Parkinson's disease
Identifieur interne : 000206 ( Pmc/Checkpoint ); précédent : 000205; suivant : 000207Sleep spindle alterations in patients with Parkinson's disease
Auteurs : Julie A. E. Christensen [Danemark, États-Unis] ; Miki Nikolic [Danemark] ; Simon C. Warby [Canada] ; Henriette Koch [Danemark, États-Unis] ; Marielle Zoetmulder [Danemark] ; Rune Frandsen [Danemark] ; Keivan K. Moghadam [Italie] ; Helge B. D. Sorensen [Danemark] ; Emmanuel Mignot [États-Unis] ; Poul J. Jennum [Danemark]Source :
- Frontiers in Human Neuroscience [ 1662-5161 ] ; 2015.
Abstract
The aim of this study was to identify changes of sleep spindles (SS) in the EEG of patients with Parkinson's disease (PD). Five sleep experts manually identified SS at a central scalp location (C3-A2) in 15 PD and 15 age- and sex-matched control subjects. Each SS was given a confidence score, and by using a group consensus rule, 901 SS were identified and characterized by their (1) duration, (2) oscillation frequency, (3) maximum peak-to-peak amplitude, (4) percent-to-peak amplitude, and (5) density. Between-group comparisons were made for all SS characteristics computed, and significant changes for PD patients vs. control subjects were found for duration, oscillation frequency, maximum peak-to-peak amplitude and density. Specifically, SS density was lower, duration was longer, oscillation frequency slower and maximum peak-to-peak amplitude higher in patients vs. controls. We also computed inter-expert reliability in SS scoring and found a significantly lower reliability in scoring definite SS in patients when compared to controls. How neurodegeneration in PD could influence SS characteristics is discussed. We also note that the SS morphological changes observed here may affect automatic detection of SS in patients with PD or other neurodegenerative disorders (NDDs).
Url:
DOI: 10.3389/fnhum.2015.00233
PubMed: 25983685
PubMed Central: 4416460
Affiliations:
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Christensen</name><affiliation wicri:level="1"><nlm:aff id="aff1"><institution>Biomedical Engineering, Department of Electrical Engineering, Technical University of Denmark</institution><country>Kongens Lyngby, Denmark</country></nlm:aff><country xml:lang="fr">Danemark</country><wicri:regionArea></wicri:regionArea></affiliation><affiliation wicri:level="1"><nlm:aff id="aff2"><institution>Danish Center for Sleep Medicine, Department of Clinical Neurophysiology, Glostrup University Hospital</institution><country>Glostrup, Denmark</country></nlm:aff><country xml:lang="fr">Danemark</country><wicri:regionArea></wicri:regionArea></affiliation><affiliation wicri:level="1"><nlm:aff id="aff3"><institution>Stanford Center for Sleep Sciences and Medicine, Psychiatry and Behavioral Sciences, Stanford University</institution><country>Palo Alto, CA, USA</country></nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea></wicri:regionArea></affiliation></author><author><name sortKey="Nikolic, Miki" sort="Nikolic, Miki" uniqKey="Nikolic M" first="Miki" last="Nikolic">Miki Nikolic</name><affiliation wicri:level="1"><nlm:aff id="aff2"><institution>Danish Center for Sleep Medicine, Department of Clinical Neurophysiology, Glostrup University Hospital</institution><country>Glostrup, Denmark</country></nlm:aff><country xml:lang="fr">Danemark</country><wicri:regionArea></wicri:regionArea></affiliation></author><author><name sortKey="Warby, Simon C" sort="Warby, Simon C" uniqKey="Warby S" first="Simon C." last="Warby">Simon C. 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E." last="Christensen">Julie A. E. Christensen</name><affiliation wicri:level="1"><nlm:aff id="aff1"><institution>Biomedical Engineering, Department of Electrical Engineering, Technical University of Denmark</institution><country>Kongens Lyngby, Denmark</country></nlm:aff><country xml:lang="fr">Danemark</country><wicri:regionArea></wicri:regionArea></affiliation><affiliation wicri:level="1"><nlm:aff id="aff2"><institution>Danish Center for Sleep Medicine, Department of Clinical Neurophysiology, Glostrup University Hospital</institution><country>Glostrup, Denmark</country></nlm:aff><country xml:lang="fr">Danemark</country><wicri:regionArea></wicri:regionArea></affiliation><affiliation wicri:level="1"><nlm:aff id="aff3"><institution>Stanford Center for Sleep Sciences and Medicine, Psychiatry and Behavioral Sciences, Stanford University</institution><country>Palo Alto, CA, USA</country></nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea></wicri:regionArea></affiliation></author><author><name sortKey="Nikolic, Miki" sort="Nikolic, Miki" uniqKey="Nikolic M" first="Miki" last="Nikolic">Miki Nikolic</name><affiliation wicri:level="1"><nlm:aff id="aff2"><institution>Danish Center for Sleep Medicine, Department of Clinical Neurophysiology, Glostrup University Hospital</institution><country>Glostrup, Denmark</country></nlm:aff><country xml:lang="fr">Danemark</country><wicri:regionArea></wicri:regionArea></affiliation></author><author><name sortKey="Warby, Simon C" sort="Warby, Simon C" uniqKey="Warby S" first="Simon C." last="Warby">Simon C. Warby</name><affiliation wicri:level="1"><nlm:aff id="aff4"><institution>Center for Advanced Research in Sleep Medicine, Sacré-Coeur Hospital of Montréal, University of Montréal</institution><country>Montréal, QC, Canada</country></nlm:aff><country xml:lang="fr">Canada</country><wicri:regionArea></wicri:regionArea></affiliation></author><author><name sortKey="Koch, Henriette" sort="Koch, Henriette" uniqKey="Koch H" first="Henriette" last="Koch">Henriette Koch</name><affiliation wicri:level="1"><nlm:aff id="aff1"><institution>Biomedical Engineering, Department of Electrical Engineering, Technical University of Denmark</institution><country>Kongens Lyngby, Denmark</country></nlm:aff><country xml:lang="fr">Danemark</country><wicri:regionArea></wicri:regionArea></affiliation><affiliation wicri:level="1"><nlm:aff id="aff2"><institution>Danish Center for Sleep Medicine, Department of Clinical Neurophysiology, Glostrup University Hospital</institution><country>Glostrup, Denmark</country></nlm:aff><country xml:lang="fr">Danemark</country><wicri:regionArea></wicri:regionArea></affiliation><affiliation wicri:level="1"><nlm:aff id="aff3"><institution>Stanford Center for Sleep Sciences and Medicine, Psychiatry and Behavioral Sciences, Stanford University</institution><country>Palo Alto, CA, USA</country></nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea></wicri:regionArea></affiliation></author><author><name sortKey="Zoetmulder, Marielle" sort="Zoetmulder, Marielle" uniqKey="Zoetmulder M" first="Marielle" last="Zoetmulder">Marielle Zoetmulder</name><affiliation wicri:level="1"><nlm:aff id="aff2"><institution>Danish Center for Sleep Medicine, Department of Clinical Neurophysiology, Glostrup University Hospital</institution><country>Glostrup, Denmark</country></nlm:aff><country xml:lang="fr">Danemark</country><wicri:regionArea></wicri:regionArea></affiliation><affiliation wicri:level="1"><nlm:aff id="aff5"><institution>Department of Neurology, Bispebjerg Hospital</institution><country>Copenhagen, Denmark</country></nlm:aff><country xml:lang="fr">Danemark</country><wicri:regionArea></wicri:regionArea></affiliation></author><author><name sortKey="Frandsen, Rune" sort="Frandsen, Rune" uniqKey="Frandsen R" first="Rune" last="Frandsen">Rune Frandsen</name><affiliation wicri:level="1"><nlm:aff id="aff2"><institution>Danish Center for Sleep Medicine, Department of Clinical Neurophysiology, Glostrup University Hospital</institution><country>Glostrup, Denmark</country></nlm:aff><country xml:lang="fr">Danemark</country><wicri:regionArea></wicri:regionArea></affiliation></author><author><name sortKey="Moghadam, Keivan K" sort="Moghadam, Keivan K" uniqKey="Moghadam K" first="Keivan K." last="Moghadam">Keivan K. Moghadam</name><affiliation wicri:level="1"><nlm:aff id="aff6"><institution>Department of Biomedical and Neuromotor Sciences (DIBINEM), University of Bologna</institution><country>Bologna, Italy</country></nlm:aff><country xml:lang="fr">Italie</country><wicri:regionArea></wicri:regionArea></affiliation></author><author><name sortKey="Sorensen, Helge B D" sort="Sorensen, Helge B D" uniqKey="Sorensen H" first="Helge B. D." last="Sorensen">Helge B. D. Sorensen</name><affiliation wicri:level="1"><nlm:aff id="aff1"><institution>Biomedical Engineering, Department of Electrical Engineering, Technical University of Denmark</institution><country>Kongens Lyngby, Denmark</country></nlm:aff><country xml:lang="fr">Danemark</country><wicri:regionArea></wicri:regionArea></affiliation></author><author><name sortKey="Mignot, Emmanuel" sort="Mignot, Emmanuel" uniqKey="Mignot E" first="Emmanuel" last="Mignot">Emmanuel Mignot</name><affiliation wicri:level="1"><nlm:aff id="aff3"><institution>Stanford Center for Sleep Sciences and Medicine, Psychiatry and Behavioral Sciences, Stanford University</institution><country>Palo Alto, CA, USA</country></nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea></wicri:regionArea></affiliation></author><author><name sortKey="Jennum, Poul J" sort="Jennum, Poul J" uniqKey="Jennum P" first="Poul J." last="Jennum">Poul J. Jennum</name><affiliation wicri:level="1"><nlm:aff id="aff2"><institution>Danish Center for Sleep Medicine, Department of Clinical Neurophysiology, Glostrup University Hospital</institution><country>Glostrup, Denmark</country></nlm:aff><country xml:lang="fr">Danemark</country><wicri:regionArea></wicri:regionArea></affiliation><affiliation wicri:level="1"><nlm:aff id="aff7"><institution>Center for Healthy Ageing, University of Copenhagen</institution><country>Copenhagen, Denmark</country></nlm:aff><country xml:lang="fr">Danemark</country><wicri:regionArea></wicri:regionArea></affiliation></author></analytic><series><title level="j">Frontiers in Human Neuroscience</title><idno type="eISSN">1662-5161</idno><imprint><date when="2015">2015</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en"><p>The aim of this study was to identify changes of sleep spindles (SS) in the EEG of patients with Parkinson's disease (PD). Five sleep experts manually identified SS at a central scalp location (C3-A2) in 15 PD and 15 age- and sex-matched control subjects. Each SS was given a confidence score, and by using a group consensus rule, 901 SS were identified and characterized by their (1) duration, (2) oscillation frequency, (3) maximum peak-to-peak amplitude, (4) percent-to-peak amplitude, and (5) density. Between-group comparisons were made for all SS characteristics computed, and significant changes for PD patients vs. control subjects were found for duration, oscillation frequency, maximum peak-to-peak amplitude and density. Specifically, SS density was lower, duration was longer, oscillation frequency slower and maximum peak-to-peak amplitude higher in patients vs. controls. We also computed inter-expert reliability in SS scoring and found a significantly lower reliability in scoring definite SS in patients when compared to controls. How neurodegeneration in PD could influence SS characteristics is discussed. We also note that the SS morphological changes observed here may affect automatic detection of SS in patients with PD or other neurodegenerative disorders (NDDs).</p></div></front><back><div1 type="bibliography"><listBibl><biblStruct></biblStruct><biblStruct><analytic><author><name sortKey="Braak, H" uniqKey="Braak H">H. Braak</name></author><author><name sortKey="Tredici, K" uniqKey="Tredici K">K. Tredici</name></author><author><name sortKey="Del Rub, U" uniqKey="Del Rub U">U. Del Rüb</name></author><author><name sortKey="Vos, R A" uniqKey="Vos R">R. A. Vos</name></author><author><name sortKey="De Steur, E N H J" uniqKey="De Steur E">E. N. H. J. de Steur</name></author><author><name sortKey="Braak, E" uniqKey="Braak E">E. Braak</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Caporro, M" uniqKey="Caporro M">M. 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<front><journal-meta><journal-id journal-id-type="nlm-ta">Front Hum Neurosci</journal-id><journal-id journal-id-type="iso-abbrev">Front Hum Neurosci</journal-id><journal-id journal-id-type="publisher-id">Front. Hum. Neurosci.</journal-id><journal-title-group><journal-title>Frontiers in Human Neuroscience</journal-title></journal-title-group><issn pub-type="epub">1662-5161</issn><publisher><publisher-name>Frontiers Media S.A.</publisher-name></publisher></journal-meta><article-meta><article-id pub-id-type="pmid">25983685</article-id><article-id pub-id-type="pmc">4416460</article-id><article-id pub-id-type="doi">10.3389/fnhum.2015.00233</article-id><article-categories><subj-group subj-group-type="heading"><subject>Neuroscience</subject><subj-group><subject>Original Research</subject></subj-group></subj-group></article-categories><title-group><article-title>Sleep spindle alterations in patients with Parkinson's disease</article-title></title-group><contrib-group><contrib contrib-type="author"><name><surname>Christensen</surname><given-names>Julie A. E.</given-names></name><xref ref-type="aff" rid="aff1"><sup>1</sup></xref><xref ref-type="aff" rid="aff2"><sup>2</sup></xref><xref ref-type="aff" rid="aff3"><sup>3</sup></xref><xref ref-type="author-notes" rid="fn001"><sup>*</sup></xref><uri xlink:type="simple" xlink:href="http://community.frontiersin.org/people/u/132992"></uri></contrib><contrib contrib-type="author"><name><surname>Nikolic</surname><given-names>Miki</given-names></name><xref ref-type="aff" rid="aff2"><sup>2</sup></xref><uri xlink:type="simple" xlink:href="http://community.frontiersin.org/people/u/213635"></uri></contrib><contrib contrib-type="author"><name><surname>Warby</surname><given-names>Simon C.</given-names></name><xref ref-type="aff" rid="aff4"><sup>4</sup></xref><uri xlink:type="simple" xlink:href="http://community.frontiersin.org/people/u/124797"></uri></contrib><contrib contrib-type="author"><name><surname>Koch</surname><given-names>Henriette</given-names></name><xref ref-type="aff" rid="aff1"><sup>1</sup></xref><xref ref-type="aff" rid="aff2"><sup>2</sup></xref><xref ref-type="aff" rid="aff3"><sup>3</sup></xref></contrib><contrib contrib-type="author"><name><surname>Zoetmulder</surname><given-names>Marielle</given-names></name><xref ref-type="aff" rid="aff2"><sup>2</sup></xref><xref ref-type="aff" rid="aff5"><sup>5</sup></xref><uri xlink:type="simple" xlink:href="http://community.frontiersin.org/people/u/231243"></uri></contrib><contrib contrib-type="author"><name><surname>Frandsen</surname><given-names>Rune</given-names></name><xref ref-type="aff" rid="aff2"><sup>2</sup></xref><uri xlink:type="simple" xlink:href="http://community.frontiersin.org/people/u/231345"></uri></contrib><contrib contrib-type="author"><name><surname>Moghadam</surname><given-names>Keivan K.</given-names></name><xref ref-type="aff" rid="aff6"><sup>6</sup></xref></contrib><contrib contrib-type="author"><name><surname>Sorensen</surname><given-names>Helge B. D.</given-names></name><xref ref-type="aff" rid="aff1"><sup>1</sup></xref><uri xlink:type="simple" xlink:href="http://community.frontiersin.org/people/u/231295"></uri></contrib><contrib contrib-type="author"><name><surname>Mignot</surname><given-names>Emmanuel</given-names></name><xref ref-type="aff" rid="aff3"><sup>3</sup></xref></contrib><contrib contrib-type="author"><name><surname>Jennum</surname><given-names>Poul J.</given-names></name><xref ref-type="aff" rid="aff2"><sup>2</sup></xref><xref ref-type="aff" rid="aff7"><sup>7</sup></xref><uri xlink:type="simple" xlink:href="http://community.frontiersin.org/people/u/15508"></uri></contrib></contrib-group><aff id="aff1"><sup>1</sup><institution>Biomedical Engineering, Department of Electrical Engineering, Technical University of Denmark</institution><country>Kongens Lyngby, Denmark</country></aff><aff id="aff2"><sup>2</sup><institution>Danish Center for Sleep Medicine, Department of Clinical Neurophysiology, Glostrup University Hospital</institution><country>Glostrup, Denmark</country></aff><aff id="aff3"><sup>3</sup><institution>Stanford Center for Sleep Sciences and Medicine, Psychiatry and Behavioral Sciences, Stanford University</institution><country>Palo Alto, CA, USA</country></aff><aff id="aff4"><sup>4</sup><institution>Center for Advanced Research in Sleep Medicine, Sacré-Coeur Hospital of Montréal, University of Montréal</institution><country>Montréal, QC, Canada</country></aff><aff id="aff5"><sup>5</sup><institution>Department of Neurology, Bispebjerg Hospital</institution><country>Copenhagen, Denmark</country></aff><aff id="aff6"><sup>6</sup><institution>Department of Biomedical and Neuromotor Sciences (DIBINEM), University of Bologna</institution><country>Bologna, Italy</country></aff><aff id="aff7"><sup>7</sup><institution>Center for Healthy Ageing, University of Copenhagen</institution><country>Copenhagen, Denmark</country></aff><author-notes><fn fn-type="edited-by"><p>Edited by: Christian O'Reilly, McGill University, Canada</p></fn><fn fn-type="edited-by"><p>Reviewed by: Ki-Young Jung, Korea University Medical Center, South Korea; Géraldine Rauchs, Institut National de la Santé et de la Recherche Médicale, France; Veronique Latreille, Hopital du Sacré-Coeur de Montréal, Canada</p></fn><corresp id="fn001">*Correspondence: Julie A. E. Christensen, Technical University of Denmark, Orsteds Plads, Building 349, DK-2800 Kongens Lyngby, Denmark <email xlink:type="simple">julie.a.e.christensen@gmail.com</email></corresp></author-notes><pub-date pub-type="epub"><day>01</day><month>5</month><year>2015</year></pub-date><pub-date pub-type="collection"><year>2015</year></pub-date><volume>9</volume><elocation-id>233</elocation-id><history><date date-type="received"><day>16</day><month>12</month><year>2014</year></date><date date-type="accepted"><day>11</day><month>4</month><year>2015</year></date></history><permissions><copyright-statement>Copyright © 2015 Christensen, Nikolic, Warby, Koch, Zoetmulder, Frandsen, Moghadam, Sorensen, Mignot and Jennum.</copyright-statement><copyright-year>2015</copyright-year><license license-type="open-access" xlink:href="http://creativecommons.org/licenses/by/4.0/"><license-p>This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.</license-p></license></permissions><abstract><p>The aim of this study was to identify changes of sleep spindles (SS) in the EEG of patients with Parkinson's disease (PD). Five sleep experts manually identified SS at a central scalp location (C3-A2) in 15 PD and 15 age- and sex-matched control subjects. Each SS was given a confidence score, and by using a group consensus rule, 901 SS were identified and characterized by their (1) duration, (2) oscillation frequency, (3) maximum peak-to-peak amplitude, (4) percent-to-peak amplitude, and (5) density. Between-group comparisons were made for all SS characteristics computed, and significant changes for PD patients vs. control subjects were found for duration, oscillation frequency, maximum peak-to-peak amplitude and density. Specifically, SS density was lower, duration was longer, oscillation frequency slower and maximum peak-to-peak amplitude higher in patients vs. controls. We also computed inter-expert reliability in SS scoring and found a significantly lower reliability in scoring definite SS in patients when compared to controls. How neurodegeneration in PD could influence SS characteristics is discussed. We also note that the SS morphological changes observed here may affect automatic detection of SS in patients with PD or other neurodegenerative disorders (NDDs).</p></abstract><kwd-group><kwd>Parkinson's disease</kwd><kwd>sleep spindle morphology</kwd><kwd>EEG</kwd><kwd>neurodegeneration</kwd><kwd>biomarker</kwd></kwd-group><counts><fig-count count="4"></fig-count><table-count count="6"></table-count><equation-count count="7"></equation-count><ref-count count="60"></ref-count><page-count count="13"></page-count><word-count count="9984"></word-count></counts></article-meta></front></pmc><affiliations><list><country><li>Canada</li><li>Danemark</li><li>Italie</li><li>États-Unis</li></country></list><tree><country name="Danemark"><noRegion><name sortKey="Christensen, Julie A E" sort="Christensen, Julie A E" uniqKey="Christensen J" first="Julie A. E." last="Christensen">Julie A. E. Christensen</name></noRegion><name sortKey="Christensen, Julie A E" sort="Christensen, Julie A E" uniqKey="Christensen J" first="Julie A. E." last="Christensen">Julie A. E. Christensen</name><name sortKey="Frandsen, Rune" sort="Frandsen, Rune" uniqKey="Frandsen R" first="Rune" last="Frandsen">Rune Frandsen</name><name sortKey="Jennum, Poul J" sort="Jennum, Poul J" uniqKey="Jennum P" first="Poul J." last="Jennum">Poul J. Jennum</name><name sortKey="Jennum, Poul J" sort="Jennum, Poul J" uniqKey="Jennum P" first="Poul J." last="Jennum">Poul J. Jennum</name><name sortKey="Koch, Henriette" sort="Koch, Henriette" uniqKey="Koch H" first="Henriette" last="Koch">Henriette Koch</name><name sortKey="Koch, Henriette" sort="Koch, Henriette" uniqKey="Koch H" first="Henriette" last="Koch">Henriette Koch</name><name sortKey="Nikolic, Miki" sort="Nikolic, Miki" uniqKey="Nikolic M" first="Miki" last="Nikolic">Miki Nikolic</name><name sortKey="Sorensen, Helge B D" sort="Sorensen, Helge B D" uniqKey="Sorensen H" first="Helge B. D." last="Sorensen">Helge B. D. Sorensen</name><name sortKey="Zoetmulder, Marielle" sort="Zoetmulder, Marielle" uniqKey="Zoetmulder M" first="Marielle" last="Zoetmulder">Marielle Zoetmulder</name><name sortKey="Zoetmulder, Marielle" sort="Zoetmulder, Marielle" uniqKey="Zoetmulder M" first="Marielle" last="Zoetmulder">Marielle Zoetmulder</name></country><country name="États-Unis"><noRegion><name sortKey="Christensen, Julie A E" sort="Christensen, Julie A E" uniqKey="Christensen J" first="Julie A. E." last="Christensen">Julie A. E. Christensen</name></noRegion><name sortKey="Koch, Henriette" sort="Koch, Henriette" uniqKey="Koch H" first="Henriette" last="Koch">Henriette Koch</name><name sortKey="Mignot, Emmanuel" sort="Mignot, Emmanuel" uniqKey="Mignot E" first="Emmanuel" last="Mignot">Emmanuel Mignot</name></country><country name="Canada"><noRegion><name sortKey="Warby, Simon C" sort="Warby, Simon C" uniqKey="Warby S" first="Simon C." last="Warby">Simon C. Warby</name></noRegion></country><country name="Italie"><noRegion><name sortKey="Moghadam, Keivan K" sort="Moghadam, Keivan K" uniqKey="Moghadam K" first="Keivan K." last="Moghadam">Keivan K. Moghadam</name></noRegion></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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