Clinical and genetic features of cervical dystonia in a large multicenter cohort
Identifieur interne : 000149 ( Pmc/Checkpoint ); précédent : 000148; suivant : 000150Clinical and genetic features of cervical dystonia in a large multicenter cohort
Auteurs : Mark S. Ledoux ; Satya R. Vemula ; Jianfeng Xiao ; Misty M. Thompson ; Joel S. Perlmutter ; Laura J. Wright ; H. A. Jinnah ; Ami R. Rosen ; Peter Hedera ; Cynthia L. Comella ; Anne Weissbach ; Johanna Junker ; Joseph Jankovic [États-Unis] ; Richard L. Barbano ; Stephen G. Reich ; Ramon L. Rodriguez ; Brian D. Berman ; Sylvain Chouinard ; Lawrence Severt ; Pinky Agarwal ; Natividad P. StoverSource :
- Neurology: Genetics [ 2376-7839 ] ; 2016.
Abstract
To characterize the clinical and genetic features of cervical dystonia (CD).
Participants enrolled in the Dystonia Coalition biorepository (NCT01373424) with initial manifestation as CD were included in this study (n = 1,000). Data intake included demographics, family history, and the Global Dystonia Rating Scale. Participants were screened for sequence variants (SVs) in
The majority of participants were Caucasian (95%) and female (75%). The mean age at onset and disease duration were 45.5 ± 13.6 and 14.6 ± 11.8 years, respectively. At the time of assessment, 68.5% had involvement limited to the neck, shoulder(s), and proximal arm(s), whereas 47.4% had dystonia limited to the neck. The remaining 31.5% of the individuals exhibited more extensive anatomical spread. A head tremor was noted in 62% of the patients. Head tremor and laryngeal dystonia were more common in females. Psychiatric comorbidities, mainly depression and anxiety, were reported by 32% of the participants and were more common in females. Family histories of dystonia, parkinsonian disorder, and tremor were present in 14%, 11%, and 29% of the patients, respectively. Pathogenic or likely pathogenic SVs in
Head tremor, laryngeal dystonia, and psychiatric comorbidities are more common in female participants with CD. Coding and noncoding variants in
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DOI: 10.1212/NXG.0000000000000069
PubMed: 27123488
PubMed Central: 4830199
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<record><TEI><teiHeader><fileDesc><titleStmt><title xml:lang="en">Clinical and genetic features of cervical dystonia in a large multicenter cohort</title><author><name sortKey="Ledoux, Mark S" sort="Ledoux, Mark S" uniqKey="Ledoux M" first="Mark S." last="Ledoux">Mark S. Ledoux</name></author><author><name sortKey="Vemula, Satya R" sort="Vemula, Satya R" uniqKey="Vemula S" first="Satya R." last="Vemula">Satya R. Vemula</name></author><author><name sortKey="Xiao, Jianfeng" sort="Xiao, Jianfeng" uniqKey="Xiao J" first="Jianfeng" last="Xiao">Jianfeng Xiao</name></author><author><name sortKey="Thompson, Misty M" sort="Thompson, Misty M" uniqKey="Thompson M" first="Misty M." last="Thompson">Misty M. Thompson</name></author><author><name sortKey="Perlmutter, Joel S" sort="Perlmutter, Joel S" uniqKey="Perlmutter J" first="Joel S." last="Perlmutter">Joel S. Perlmutter</name></author><author><name sortKey="Wright, Laura J" sort="Wright, Laura J" uniqKey="Wright L" first="Laura J." last="Wright">Laura J. Wright</name></author><author><name sortKey="Jinnah, H A" sort="Jinnah, H A" uniqKey="Jinnah H" first="H. A." last="Jinnah">H. A. Jinnah</name></author><author><name sortKey="Rosen, Ami R" sort="Rosen, Ami R" uniqKey="Rosen A" first="Ami R." last="Rosen">Ami R. Rosen</name></author><author><name sortKey="Hedera, Peter" sort="Hedera, Peter" uniqKey="Hedera P" first="Peter" last="Hedera">Peter Hedera</name></author><author><name sortKey="Comella, Cynthia L" sort="Comella, Cynthia L" uniqKey="Comella C" first="Cynthia L." last="Comella">Cynthia L. Comella</name></author><author><name sortKey="Weissbach, Anne" sort="Weissbach, Anne" uniqKey="Weissbach A" first="Anne" last="Weissbach">Anne Weissbach</name></author><author><name sortKey="Junker, Johanna" sort="Junker, Johanna" uniqKey="Junker J" first="Johanna" last="Junker">Johanna Junker</name></author><author><name sortKey="Jankovic, Joseph" sort="Jankovic, Joseph" uniqKey="Jankovic J" first="Joseph" last="Jankovic">Joseph Jankovic</name><affiliation><country>États-Unis</country><placeName><settlement type="city">Houston</settlement><region type="state">Texas</region></placeName><orgName type="university" n="3">Baylor College of Medicine</orgName></affiliation></author><author><name sortKey="Barbano, Richard L" sort="Barbano, Richard L" uniqKey="Barbano R" first="Richard L." last="Barbano">Richard L. Barbano</name></author><author><name sortKey="Reich, Stephen G" sort="Reich, Stephen G" uniqKey="Reich S" first="Stephen G." last="Reich">Stephen G. Reich</name></author><author><name sortKey="Rodriguez, Ramon L" sort="Rodriguez, Ramon L" uniqKey="Rodriguez R" first="Ramon L." last="Rodriguez">Ramon L. Rodriguez</name></author><author><name sortKey="Berman, Brian D" sort="Berman, Brian D" uniqKey="Berman B" first="Brian D." last="Berman">Brian D. Berman</name></author><author><name sortKey="Chouinard, Sylvain" sort="Chouinard, Sylvain" uniqKey="Chouinard S" first="Sylvain" last="Chouinard">Sylvain Chouinard</name></author><author><name sortKey="Severt, Lawrence" sort="Severt, Lawrence" uniqKey="Severt L" first="Lawrence" last="Severt">Lawrence Severt</name></author><author><name sortKey="Agarwal, Pinky" sort="Agarwal, Pinky" uniqKey="Agarwal P" first="Pinky" last="Agarwal">Pinky Agarwal</name></author><author><name sortKey="Stover, Natividad P" sort="Stover, Natividad P" uniqKey="Stover N" first="Natividad P." last="Stover">Natividad P. Stover</name></author></titleStmt><publicationStmt><idno type="wicri:source">PMC</idno><idno type="pmid">27123488</idno><idno type="pmc">4830199</idno><idno type="url">http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4830199</idno><idno type="RBID">PMC:4830199</idno><idno type="doi">10.1212/NXG.0000000000000069</idno><date when="2016">2016</date><idno type="wicri:Area/Pmc/Corpus">000A49</idno><idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Corpus" wicri:corpus="PMC">000A49</idno><idno type="wicri:Area/Pmc/Curation">000A49</idno><idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Curation">000A49</idno><idno type="wicri:Area/Pmc/Checkpoint">000149</idno><idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Checkpoint">000149</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en" level="a" type="main">Clinical and genetic features of cervical dystonia in a large multicenter cohort</title><author><name sortKey="Ledoux, Mark S" sort="Ledoux, Mark S" uniqKey="Ledoux M" first="Mark S." last="Ledoux">Mark S. Ledoux</name></author><author><name sortKey="Vemula, Satya R" sort="Vemula, Satya R" uniqKey="Vemula S" first="Satya R." last="Vemula">Satya R. Vemula</name></author><author><name sortKey="Xiao, Jianfeng" sort="Xiao, Jianfeng" uniqKey="Xiao J" first="Jianfeng" last="Xiao">Jianfeng Xiao</name></author><author><name sortKey="Thompson, Misty M" sort="Thompson, Misty M" uniqKey="Thompson M" first="Misty M." last="Thompson">Misty M. Thompson</name></author><author><name sortKey="Perlmutter, Joel S" sort="Perlmutter, Joel S" uniqKey="Perlmutter J" first="Joel S." last="Perlmutter">Joel S. Perlmutter</name></author><author><name sortKey="Wright, Laura J" sort="Wright, Laura J" uniqKey="Wright L" first="Laura J." last="Wright">Laura J. Wright</name></author><author><name sortKey="Jinnah, H A" sort="Jinnah, H A" uniqKey="Jinnah H" first="H. A." last="Jinnah">H. A. Jinnah</name></author><author><name sortKey="Rosen, Ami R" sort="Rosen, Ami R" uniqKey="Rosen A" first="Ami R." last="Rosen">Ami R. Rosen</name></author><author><name sortKey="Hedera, Peter" sort="Hedera, Peter" uniqKey="Hedera P" first="Peter" last="Hedera">Peter Hedera</name></author><author><name sortKey="Comella, Cynthia L" sort="Comella, Cynthia L" uniqKey="Comella C" first="Cynthia L." last="Comella">Cynthia L. Comella</name></author><author><name sortKey="Weissbach, Anne" sort="Weissbach, Anne" uniqKey="Weissbach A" first="Anne" last="Weissbach">Anne Weissbach</name></author><author><name sortKey="Junker, Johanna" sort="Junker, Johanna" uniqKey="Junker J" first="Johanna" last="Junker">Johanna Junker</name></author><author><name sortKey="Jankovic, Joseph" sort="Jankovic, Joseph" uniqKey="Jankovic J" first="Joseph" last="Jankovic">Joseph Jankovic</name><affiliation><country>États-Unis</country><placeName><settlement type="city">Houston</settlement><region type="state">Texas</region></placeName><orgName type="university" n="3">Baylor College of Medicine</orgName></affiliation></author><author><name sortKey="Barbano, Richard L" sort="Barbano, Richard L" uniqKey="Barbano R" first="Richard L." last="Barbano">Richard L. Barbano</name></author><author><name sortKey="Reich, Stephen G" sort="Reich, Stephen G" uniqKey="Reich S" first="Stephen G." last="Reich">Stephen G. Reich</name></author><author><name sortKey="Rodriguez, Ramon L" sort="Rodriguez, Ramon L" uniqKey="Rodriguez R" first="Ramon L." last="Rodriguez">Ramon L. Rodriguez</name></author><author><name sortKey="Berman, Brian D" sort="Berman, Brian D" uniqKey="Berman B" first="Brian D." last="Berman">Brian D. Berman</name></author><author><name sortKey="Chouinard, Sylvain" sort="Chouinard, Sylvain" uniqKey="Chouinard S" first="Sylvain" last="Chouinard">Sylvain Chouinard</name></author><author><name sortKey="Severt, Lawrence" sort="Severt, Lawrence" uniqKey="Severt L" first="Lawrence" last="Severt">Lawrence Severt</name></author><author><name sortKey="Agarwal, Pinky" sort="Agarwal, Pinky" uniqKey="Agarwal P" first="Pinky" last="Agarwal">Pinky Agarwal</name></author><author><name sortKey="Stover, Natividad P" sort="Stover, Natividad P" uniqKey="Stover N" first="Natividad P." last="Stover">Natividad P. Stover</name></author></analytic><series><title level="j">Neurology: Genetics</title><idno type="eISSN">2376-7839</idno><imprint><date when="2016">2016</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en"><sec><title>Objective:</title><p>To characterize the clinical and genetic features of cervical dystonia (CD).</p></sec><sec><title>Methods:</title><p>Participants enrolled in the Dystonia Coalition biorepository (NCT01373424) with initial manifestation as CD were included in this study (n = 1,000). Data intake included demographics, family history, and the Global Dystonia Rating Scale. Participants were screened for sequence variants (SVs) in <italic>GNAL</italic>, <italic>THAP1</italic>, and Exon 5 of <italic>TOR1A</italic>.</p></sec><sec><title>Results:</title><p>The majority of participants were Caucasian (95%) and female (75%). The mean age at onset and disease duration were 45.5 ± 13.6 and 14.6 ± 11.8 years, respectively. At the time of assessment, 68.5% had involvement limited to the neck, shoulder(s), and proximal arm(s), whereas 47.4% had dystonia limited to the neck. The remaining 31.5% of the individuals exhibited more extensive anatomical spread. A head tremor was noted in 62% of the patients. Head tremor and laryngeal dystonia were more common in females. Psychiatric comorbidities, mainly depression and anxiety, were reported by 32% of the participants and were more common in females. Family histories of dystonia, parkinsonian disorder, and tremor were present in 14%, 11%, and 29% of the patients, respectively. Pathogenic or likely pathogenic SVs in <italic>THAP1</italic>, <italic>TOR1A</italic>, and <italic>GNAL</italic> were identified in 8 participants (0.8%). Two individuals harbored novel missense SVs in Exon 5 of <italic>TOR1A</italic>. Synonymous and noncoding SVs in <italic>THAP1</italic> and <italic>GNAL</italic> were identified in 4% of the cohort.</p></sec><sec><title>Conclusions:</title><p>Head tremor, laryngeal dystonia, and psychiatric comorbidities are more common in female participants with CD. Coding and noncoding variants in <italic>GNAL</italic>, <italic>THAP1</italic>, and <italic>TOR1A</italic> make small contributions to the pathogenesis of CD.</p></sec></div></front><back><div1 type="bibliography"><listBibl><biblStruct><analytic><author><name sortKey="Defazio, G" uniqKey="Defazio G">G Defazio</name></author><author><name sortKey="Jankovic, J" uniqKey="Jankovic J">J Jankovic</name></author><author><name sortKey="Giel, Jl" uniqKey="Giel J">JL Giel</name></author><author><name sortKey="Papapetropoulos, S" uniqKey="Papapetropoulos S">S Papapetropoulos</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Defazio, G" uniqKey="Defazio G">G Defazio</name></author><author><name sortKey="Abbruzzese, G" uniqKey="Abbruzzese G">G Abbruzzese</name></author><author><name sortKey="Livrea, P" uniqKey="Livrea P">P Livrea</name></author><author><name sortKey="Berardelli, A" uniqKey="Berardelli A">A 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Zhao</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Calakos, N" uniqKey="Calakos N">N Calakos</name></author><author><name sortKey="Patel, Vd" uniqKey="Patel V">VD Patel</name></author><author><name sortKey="Gottron, M" uniqKey="Gottron M">M Gottron</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Zirn, B" uniqKey="Zirn B">B Zirn</name></author><author><name sortKey="Grundmann, K" uniqKey="Grundmann K">K Grundmann</name></author><author><name sortKey="Huppke, P" uniqKey="Huppke P">P Huppke</name></author></analytic></biblStruct></listBibl></div1></back></TEI><pmc article-type="research-article"><pmc-dir>properties open_access</pmc-dir>
<front><journal-meta><journal-id journal-id-type="nlm-ta">Neurol Genet</journal-id><journal-id journal-id-type="iso-abbrev">Neurol Genet</journal-id><journal-id journal-id-type="hwp">nng</journal-id><journal-id journal-id-type="publisher-id">NNG</journal-id><journal-title-group><journal-title>Neurology: Genetics</journal-title></journal-title-group><issn pub-type="epub">2376-7839</issn><publisher><publisher-name>Wolters Kluwer</publisher-name><publisher-loc>Baltimore</publisher-loc></publisher></journal-meta><article-meta><article-id pub-id-type="pmid">27123488</article-id><article-id pub-id-type="pmc">4830199</article-id><article-id pub-id-type="publisher-id">NG2016002071</article-id><article-id pub-id-type="doi">10.1212/NXG.0000000000000069</article-id><article-categories><subj-group subj-group-type="hwp-journal-coll"><subject>91</subject><subject>162</subject><subject>165</subject><subject>168</subject><subject>173</subject></subj-group><subj-group subj-group-type="heading"><subject>Article</subject></subj-group></article-categories><title-group><article-title>Clinical and genetic features of cervical dystonia in a large multicenter cohort</article-title></title-group><contrib-group><contrib contrib-type="author" corresp="yes"><name><surname>LeDoux</surname><given-names>Mark S.</given-names></name><degrees>MD, PhD</degrees><author-comment content-type="disclosure"><p><list list-type="order"><title>Scientific Advisory Boards:</title><list-item><p>(1) Chairman, Board of Medical Advisors, National Spasmodic Torticollis Association (2) Member, Scientific Advisory Board, Spastic Paraplegia Foundation</p></list-item></list></p><p><list list-type="order"><title>Gifts:</title><list-item><p>NONE</p></list-item></list></p><p><list list-type="order"><title>Funding for Travel or Speaker Honoraria:</title><list-item><p>(1)Teva, Speaker, 2009 - present (2)Lundbeck, Speaker, 2010 - present</p></list-item></list></p><p><list list-type="order"><title>Editorial Boards:</title><list-item><p>Parkinsonism and Related Disorders, Editorial Board, 2008-present. Tremor and Other Hyperkinetic Movement Disorders, Editorial Board, 2011-present. PLOS ONE, 2014-present. Neurology, 2015-present.</p></list-item></list></p><p><list list-type="order"><title>Patents:</title><list-item><p>NONE</p></list-item></list></p><p><list list-type="order"><title>Publishing Royalties:</title><list-item><p>Elsevier, Animal Models of Movement Disorders, 2005-present. Elsevier, Movement Disorders: Genetics and Models, 2015-present</p></list-item></list></p><p><list list-type="order"><title>Employment, Commercial Entity:</title><list-item><p>(1) University of Tennessee Health Science Center, 1997-present</p></list-item></list></p><p><list list-type="order"><title>Consultancies:</title><list-item><p>(1) Azilect Advisory Board, Teva, 2011- present (2) Advisory Board, Lundbeck, 2010 - present (3) Consultant, Mayo Clinic, 2013 - present.</p></list-item></list></p><p><list list-type="order"><title>Speakers' Bureaus:</title><list-item><p>(1)Teva, Speaker, 2009 - present (2)Lundbeck, Speaker, 2010 - present</p></list-item></list></p><p><list list-type="order"><title>Other Activities:</title><list-item><p>NONE</p></list-item></list></p><p><list list-type="order"><title>Clinical Procedures or Imaging Studies:</title><list-item><p>NONE</p></list-item></list></p><p><list list-type="order"><title>Research Support, Commercial Entities:</title><list-item><p>(1) CHDI,Enroll-HD, July 2012 to present (2) Prana Biotechnology, Reach2HD, July 2012 to April 2013 (3) Omeros, Phase 2 Randomized, Double-Blind, Placebo-Controlled, Sequential Cohort Study to Evaluate Safety and Efficacy of OMS643762 in Subjects with Huntington?s Disease, June 2014-present (4)Auspex, SD-809-C-18 and SD-809-C-20, Randomized, Double-Blind, Placebo-Controlled Study of SD-809 (Deutetrabenazine) for the Treatment of Moderate to Severe Tardive Dyskinesia and SD809-C-20 An Open-Label, Long-Term Safety Study of SD-809 (Deutetrabenazine) for the Treatment of Moderate to Severe Tardive Dyskinesia (LeDoux-Site PI), 9/22/2014 - present (5) US WorldMeds, Mysticol, Protocol SN-SIAL-301, ?A Phase 3, Multicenter, Double-Blind, Placebo-Controlled, Single-Treatment Efficacy and Safety study of MYOBLOC? (Part A) Followed by Open-Label, Multiple-Treatment with MYOBLOC? (Part B) in the Treatment of Troublesome Sialorrhea in Adult Subjects (LeDoux - Site PI), 11/1/2014 - present (6)Auspex, SD-809-C-23, Randomized, Double-Blind, Placebo-Controlled, Fixed-Dose Study of SD-809 (Deutetrabenazine) for the Treatment of Moderate to Severe Tardive Dyskinesia (LeDoux-Site PI), 03/03/2015 - present (7) Accorda, DALF-PS-1016, (MILESTONE) A Study to Evaluate the Efficacy and Safety of Two Dose Strengths of Dalfampridine Extended Release Tablets for Treatment of Stable Walking Deficits in Post-Ischemic Stroke(LeDoux-Site PI), 01AUG2015 - present (8) US WorldMeds, OPTIMYST, Protocol SN-SIAL-351, ?Open-Label and Single-Arm Study of MYOBLOC? in the Treatment of Troublesome Sialorrhea in Adults (LeDoux-Site PI), 15DEC2015 - present</p></list-item></list></p><p><list list-type="order"><title>Research Support, Government Entities:</title><list-item><p>(1) National Institutes of Health, U54NS065701, Prospective Natural History Study and Biorepository, May 2011 to present (2) NIH/NINDS, R01NS069936, The Role of THAP1 in Dystonia, August 2010 to present (3)NIH/NCCAM 5U01AT000613, ?CREST-E,? (Steven M. Hersch, PI; Mark LeDoux, Site-PI) Creatine Safety, Tolerability, and Efficacy in Huntington?s Disease, 01OCT2010-30SEP2015 (4)NIH/NINDS, ?2CARE?, (Merit Cudkowicz-PI; LeDoux-Site PI) 2CARE is a definitive long-term, multi-center, placebo-controlled clinical trial of high dose coenzyme Q10 (CoQ) in Huntington?s disease. 01APR2008-30JUN2014 (5)NIH/NINDS, R01NS082296, Genetics and Biology of CIZ1 in Cervical Dystonia, 13SEP2013-30JUN2017</p></list-item></list></p><p><list list-type="order"><title>Research Support, Academic Entities:</title><list-item><p>NONE</p></list-item></list></p><p><list list-type="order"><title>Research Support, Foundations and Societies:</title><list-item><p>Benign Essential Blepharospasm Research FDN, ?Genetics of Blepharospasm? LeDoux-PI), 01/01/15 - 12/31/15</p></list-item></list></p><p><list list-type="order"><title>Stock/Stock Options/Board of Directors Compensation:</title><list-item><p>NONE</p></list-item></list></p><p><list list-type="order"><title>License Fee Payments, Technology or Inventions:</title><list-item><p>NONE</p></list-item></list></p><p><list list-type="order"><title>Royalty Payments, Technology or Inventions:</title><list-item><p>NONE</p></list-item></list></p><p><list list-type="order"><title>Stock/Stock Options, Research Sponsor:</title><list-item><p>NONE</p></list-item></list></p><p><list list-type="order"><title>Stock/Stock Options, Medical Equipment & Materials:</title><list-item><p>NONE</p></list-item></list></p><p><list list-type="order"><title>Legal Proceedings:</title><list-item><p>NONE</p></list-item></list></p></author-comment></contrib><contrib contrib-type="author"><name><surname>Vemula</surname><given-names>Satya R.</given-names></name><degrees>PhD</degrees><author-comment content-type="disclosure"><p><list list-type="order"><title>Scientific Advisory Boards:</title><list-item><p>NONE</p></list-item></list></p><p><list list-type="order"><title>Gifts:</title><list-item><p>NONE</p></list-item></list></p><p><list list-type="order"><title>Funding for Travel or Speaker Honoraria:</title><list-item><p>NONE</p></list-item></list></p><p><list list-type="order"><title>Editorial Boards:</title><list-item><p>NONE</p></list-item></list></p><p><list list-type="order"><title>Patents:</title><list-item><p>NONE</p></list-item></list></p><p><list list-type="order"><title>Publishing Royalties:</title><list-item><p>NONE</p></list-item></list></p><p><list list-type="order"><title>Employment, Commercial Entity:</title><list-item><p>NONE</p></list-item></list></p><p><list list-type="order"><title>Consultancies:</title><list-item><p>NONE</p></list-item></list></p><p><list list-type="order"><title>Speakers' Bureaus:</title><list-item><p>NONE</p></list-item></list></p><p><list list-type="order"><title>Other Activities:</title><list-item><p>NONE</p></list-item></list></p><p><list list-type="order"><title>Clinical Procedures or Imaging Studies:</title><list-item><p>NONE</p></list-item></list></p><p><list list-type="order"><title>Research Support, Commercial Entities:</title><list-item><p>NONE</p></list-item></list></p><p><list list-type="order"><title>Research Support, Government Entities:</title><list-item><p>NONE</p></list-item></list></p><p><list list-type="order"><title>Research Support, Academic Entities:</title><list-item><p>NONE</p></list-item></list></p><p><list list-type="order"><title>Research Support, Foundations and Societies:</title><list-item><p>NONE</p></list-item></list></p><p><list list-type="order"><title>Stock/Stock Options/Board of Directors Compensation:</title><list-item><p>NONE</p></list-item></list></p><p><list list-type="order"><title>License Fee Payments, Technology or Inventions:</title><list-item><p>NONE</p></list-item></list></p><p><list list-type="order"><title>Royalty Payments, Technology or Inventions:</title><list-item><p>NONE</p></list-item></list></p><p><list list-type="order"><title>Stock/Stock Options, Research Sponsor:</title><list-item><p>NONE</p></list-item></list></p><p><list list-type="order"><title>Stock/Stock Options, Medical Equipment & Materials:</title><list-item><p>NONE</p></list-item></list></p><p><list list-type="order"><title>Legal Proceedings:</title><list-item><p>NONE</p></list-item></list></p></author-comment></contrib><contrib contrib-type="author"><name><surname>Xiao</surname><given-names>Jianfeng</given-names></name><degrees>MD, PhD</degrees><author-comment content-type="disclosure"><p><list list-type="order"><title>Scientific Advisory Boards:</title><list-item><p>NONE</p></list-item></list></p><p><list list-type="order"><title>Gifts:</title><list-item><p>NONE</p></list-item></list></p><p><list list-type="order"><title>Funding for Travel or Speaker Honoraria:</title><list-item><p>NONE</p></list-item></list></p><p><list list-type="order"><title>Editorial Boards:</title><list-item><p>NONE</p></list-item></list></p><p><list list-type="order"><title>Patents:</title><list-item><p>NONE</p></list-item></list></p><p><list list-type="order"><title>Publishing Royalties:</title><list-item><p>NONE</p></list-item></list></p><p><list list-type="order"><title>Employment, Commercial Entity:</title><list-item><p>NONE</p></list-item></list></p><p><list list-type="order"><title>Consultancies:</title><list-item><p>NONE</p></list-item></list></p><p><list list-type="order"><title>Speakers' Bureaus:</title><list-item><p>NONE</p></list-item></list></p><p><list list-type="order"><title>Other Activities:</title><list-item><p>NONE</p></list-item></list></p><p><list list-type="order"><title>Clinical Procedures or Imaging Studies:</title><list-item><p>NONE</p></list-item></list></p><p><list list-type="order"><title>Research Support, Commercial Entities:</title><list-item><p>NONE</p></list-item></list></p><p><list list-type="order"><title>Research Support, Government Entities:</title><list-item><p>NONE</p></list-item></list></p><p><list list-type="order"><title>Research Support, Academic Entities:</title><list-item><p>NONE</p></list-item></list></p><p><list list-type="order"><title>Research Support, Foundations and Societies:</title><list-item><p>NONE</p></list-item></list></p><p><list list-type="order"><title>Stock/Stock Options/Board of Directors Compensation:</title><list-item><p>NONE</p></list-item></list></p><p><list list-type="order"><title>License Fee Payments, Technology or Inventions:</title><list-item><p>NONE</p></list-item></list></p><p><list list-type="order"><title>Royalty Payments, Technology or Inventions:</title><list-item><p>NONE</p></list-item></list></p><p><list list-type="order"><title>Stock/Stock Options, Research Sponsor:</title><list-item><p>NONE</p></list-item></list></p><p><list list-type="order"><title>Stock/Stock Options, Medical Equipment & Materials:</title><list-item><p>NONE</p></list-item></list></p><p><list list-type="order"><title>Legal Proceedings:</title><list-item><p>NONE</p></list-item></list></p></author-comment></contrib><contrib contrib-type="author"><name><surname>Thompson</surname><given-names>Misty M.</given-names></name><degrees>PhD</degrees><author-comment content-type="disclosure"><p><list list-type="order"><title>Scientific Advisory Boards:</title><list-item><p>NONE</p></list-item></list></p><p><list list-type="order"><title>Gifts:</title><list-item><p>NONE</p></list-item></list></p><p><list list-type="order"><title>Funding for Travel or Speaker Honoraria:</title><list-item><p>NONE</p></list-item></list></p><p><list list-type="order"><title>Editorial Boards:</title><list-item><p>NONE</p></list-item></list></p><p><list list-type="order"><title>Patents:</title><list-item><p>NONE</p></list-item></list></p><p><list list-type="order"><title>Publishing Royalties:</title><list-item><p>NONE</p></list-item></list></p><p><list list-type="order"><title>Employment, Commercial Entity:</title><list-item><p>NONE</p></list-item></list></p><p><list list-type="order"><title>Consultancies:</title><list-item><p>NONE</p></list-item></list></p><p><list list-type="order"><title>Speakers' Bureaus:</title><list-item><p>NONE</p></list-item></list></p><p><list list-type="order"><title>Other Activities:</title><list-item><p>NONE</p></list-item></list></p><p><list list-type="order"><title>Clinical Procedures or Imaging Studies:</title><list-item><p>NONE</p></list-item></list></p><p><list list-type="order"><title>Research Support, Commercial Entities:</title><list-item><p>NONE</p></list-item></list></p><p><list list-type="order"><title>Research Support, Government Entities:</title><list-item><p>NONE</p></list-item></list></p><p><list list-type="order"><title>Research Support, Academic Entities:</title><list-item><p>NONE</p></list-item></list></p><p><list list-type="order"><title>Research Support, Foundations and Societies:</title><list-item><p>NONE</p></list-item></list></p><p><list list-type="order"><title>Stock/Stock Options/Board of Directors Compensation:</title><list-item><p>NONE</p></list-item></list></p><p><list list-type="order"><title>License Fee Payments, Technology or Inventions:</title><list-item><p>NONE</p></list-item></list></p><p><list list-type="order"><title>Royalty Payments, Technology or Inventions:</title><list-item><p>NONE</p></list-item></list></p><p><list list-type="order"><title>Stock/Stock Options, Research Sponsor:</title><list-item><p>NONE</p></list-item></list></p><p><list list-type="order"><title>Stock/Stock Options, Medical Equipment & Materials:</title><list-item><p>NONE</p></list-item></list></p><p><list list-type="order"><title>Legal Proceedings:</title><list-item><p>NONE</p></list-item></list></p></author-comment></contrib><contrib contrib-type="author"><name><surname>Perlmutter</surname><given-names>Joel S.</given-names></name><degrees>MD</degrees><author-comment content-type="disclosure"><p><list list-type="order"><title>Scientific Advisory Boards:</title><list-item><p>American Parkinson Disease Association, Scientific Advisory Board, currently, no compensation Dystonia Medical Research Foundation, Medical and Scientific Advisory Board, no compensation MO Chapter of the Dystonia Medical Research Fund, medical advisory board, no compensation Greater St. Louis Chapter of the APDA, medical advisory board, no compensation co-chair of scientific advisory committee of the Parkinson study group chair of the scientific publication and data committee for ENROLL sponsored by CHDI (no compensation)</p></list-item></list></p><p><list list-type="order"><title>Gifts:</title><list-item><p>NONE</p></list-item></list></p><p><list list-type="order"><title>Funding for Travel or Speaker Honoraria:</title><list-item><p>1. U Louisville, honorarium 2. Toronto Western Hospital, Honorarium 3. U Maryland, honorarium 4. Weil Cornell School of Medicine, honorarium 5. U Saskatoon, honorarium 6. Movement disorders Society, honorarium 7. Society of Nuclear Medicine, honorarium 8. Rhode Island General Hospital honorarium 9. Medical University of South Carolina honorarium 10. St. Lukes Hospital in St. Louis County Honorarium 11. Emory University honorarium 12. American Academy of Neurology, honorarium 13.Parkinson Disease Foundation, honorarium 14. Columbia University, honorarium 15. Indiana Neurological Society, honorarium 16. Beth Israel Hospital, Harvard medical School, paid expenses only 17. University of Missouri, Columbia, paid expenses only 18. American Parkinson Disease Association, paid expenses only 19. st. Louis University, honorarium for lecture 20. University of Michigan, honorarium for lecture and travel expenses 21. Harvard University, honorarium for lecture and travelexpenses</p></list-item></list></p><p><list list-type="order"><title>Editorial Boards:</title><list-item><p>Neurology, Editorial Board, no compensation, currently Movement Disorders Journal, 2003-2008, no compensation</p></list-item></list></p><p><list list-type="order"><title>Patents:</title><list-item><p>NONE</p></list-item></list></p><p><list list-type="order"><title>Publishing Royalties:</title><list-item><p>NONE</p></list-item></list></p><p><list list-type="order"><title>Employment, Commercial Entity:</title><list-item><p>NONE</p></list-item></list></p><p><list list-type="order"><title>Consultancies:</title><list-item><p>reviewed grant for Alberta Innovates reviewed grant for Pennsylvania State University reviewed grants for NIH/NINDS</p></list-item></list></p><p><list list-type="order"><title>Speakers' Bureaus:</title><list-item><p>NONE</p></list-item></list></p><p><list list-type="order"><title>Other Activities:</title><list-item><p>Parkinson Disease Study Group, paid for grant reviews, 2008, 2009, 2010, 2011, 2012,2013 Medtronic Inc, partial fellowship support for my section 2006-2009 Huntington Study group, paid for grant review, 2013</p></list-item></list></p><p><list list-type="order"><title>Clinical Procedures or Imaging Studies:</title><list-item><p>NONE</p></list-item></list></p><p><list list-type="order"><title>Research Support, Commercial Entities:</title><list-item><p>Medtronic Inc, 2006-2009, provided partial fellowship support. We no longer accept this. Express Scripts, 2011, provided research support for investigation of phase 4 clinical trials</p></list-item></list></p><p><list list-type="order"><title>Research Support, Government Entities:</title><list-item><p>NIH: (Perlmutter)4/1/01 ? 9/30/2016 NIH RO1 1RO1NS41509 ?Mechanisms of Deep Brain Stimulation? Role: PI (Perlmutter)7/15/05 - 3/31/11 NIH RO1 NS050425, Role: PI ?Carboxyfullerene treatment of MPTP-induced parkinsonism? (Perlmutter)RO1 NS058714 ?Validation of Neuroimaging Biomarkers for Nigrostriatal Neurons? 7/1/08 ? 6/30/12 Role: PI. (Perlmutter) RO1 NS075321</p></list-item></list></p><p><list list-type="order"><title>Research Support, Academic Entities:</title><list-item><p>Collaborative research agreement with University of Toronto to support MARS (medical automated records system). University of Toronto pays Washington University for this support.</p></list-item></list></p><p><list list-type="order"><title>Research Support, Foundations and Societies:</title><list-item><p>Huntington Disease Society of American Center of Excellence: current - 2014 Bander Fund for Medical Business Ethics: Funding for study of phase 4 clinical trials and their role in marketing Fixel Foundation for preclinical research study on carboxyfullerene MJ Fox Foundation Neuroimaging Biomarkers Study; 2009-2012 Mach 5/11/2011 ? 11/11/12 MJ Fox Foundation Developing an alpha-synuclein imaging agent The goal of this study is to develop radioligand agents to be used for in vivo PET studies to measure alpha-synuclein in the brain. Role: co-investigator CHDI: Support for HD clinical studies 2007-current McDonnell Center for Higher Brain Function: support imaging research Greater St. Louis Chapter of the American Parkinson Disease Association: - 2005-2014 Investigations of Dementia in PD. American Parkinson Disease Association; APDA Advanced PD Research Center at Washington University; 2007-2014 (PI: Perlmutter) BJH Foundation, ?Support for Replacement Research PET Scanner for NeuroICU? 4/1/2007?3/31/2008 This supported purchase of a replacement PET scanner used for neuroscience research.</p></list-item></list></p><p><list list-type="order"><title>Stock/Stock Options/Board of Directors Compensation:</title><list-item><p>NONE</p></list-item></list></p><p><list list-type="order"><title>License Fee Payments, Technology or Inventions:</title><list-item><p>NONE</p></list-item></list></p><p><list list-type="order"><title>Royalty Payments, Technology or Inventions:</title><list-item><p>NONE</p></list-item></list></p><p><list list-type="order"><title>Stock/Stock Options, Research Sponsor:</title><list-item><p>NONE</p></list-item></list></p><p><list list-type="order"><title>Stock/Stock Options, Medical Equipment & Materials:</title><list-item><p>NONE</p></list-item></list></p><p><list list-type="order"><title>Legal Proceedings:</title><list-item><p>Gave deposition requested by defense attorney (defending a railroad and I was paid by the defense attorney) regarding a work-related injury sustained by one of my patients who is the plaintiff. 2011. reviewed medical records for personal injury case regarding tardive dyskinesia; 2013 reviewed medical records and examined plaintiff for personal injury case regarding cervical dystonia; 2013 & 2014 reviewed medical records for a Parkinson disease case; 2014 reviewed medical records for a Parkinson disease case 2015 reviewed literature for a trauma induced parkinson lawsuit 2015</p></list-item></list></p></author-comment></contrib><contrib contrib-type="author"><name><surname>Wright</surname><given-names>Laura J.</given-names></name><degrees>MA</degrees><author-comment content-type="disclosure"><p><list list-type="order"><title>Scientific Advisory Boards:</title><list-item><p>NONE</p></list-item></list></p><p><list list-type="order"><title>Gifts:</title><list-item><p>NONE</p></list-item></list></p><p><list list-type="order"><title>Funding for Travel or Speaker Honoraria:</title><list-item><p>NONE</p></list-item></list></p><p><list list-type="order"><title>Editorial Boards:</title><list-item><p>NONE</p></list-item></list></p><p><list list-type="order"><title>Patents:</title><list-item><p>NONE</p></list-item></list></p><p><list list-type="order"><title>Publishing Royalties:</title><list-item><p>NONE</p></list-item></list></p><p><list list-type="order"><title>Employment, Commercial Entity:</title><list-item><p>NONE</p></list-item></list></p><p><list list-type="order"><title>Consultancies:</title><list-item><p>NONE</p></list-item></list></p><p><list list-type="order"><title>Speakers' Bureaus:</title><list-item><p>NONE</p></list-item></list></p><p><list list-type="order"><title>Other Activities:</title><list-item><p>NONE</p></list-item></list></p><p><list list-type="order"><title>Clinical Procedures or Imaging Studies:</title><list-item><p>NONE</p></list-item></list></p><p><list list-type="order"><title>Research Support, Commercial Entities:</title><list-item><p>NONE</p></list-item></list></p><p><list list-type="order"><title>Research Support, Government Entities:</title><list-item><p>NONE</p></list-item></list></p><p><list list-type="order"><title>Research Support, Academic Entities:</title><list-item><p>NONE</p></list-item></list></p><p><list list-type="order"><title>Research Support, Foundations and Societies:</title><list-item><p>NONE</p></list-item></list></p><p><list list-type="order"><title>Stock/Stock Options/Board of Directors Compensation:</title><list-item><p>NONE</p></list-item></list></p><p><list list-type="order"><title>License Fee Payments, Technology or Inventions:</title><list-item><p>NONE</p></list-item></list></p><p><list list-type="order"><title>Royalty Payments, Technology or Inventions:</title><list-item><p>NONE</p></list-item></list></p><p><list list-type="order"><title>Stock/Stock Options, Research Sponsor:</title><list-item><p>NONE</p></list-item></list></p><p><list list-type="order"><title>Stock/Stock Options, Medical Equipment & Materials:</title><list-item><p>NONE</p></list-item></list></p><p><list list-type="order"><title>Legal Proceedings:</title><list-item><p>NONE</p></list-item></list></p></author-comment></contrib><contrib contrib-type="author"><name><surname>Jinnah</surname><given-names>H.A.</given-names></name><degrees>MD, PhD</degrees><author-comment content-type="disclosure"><p><list list-type="order"><title>Scientific Advisory Boards:</title><list-item><p>Medtronic, Inc.</p></list-item></list></p><p><list list-type="order"><title>Gifts:</title><list-item><p>NONE</p></list-item></list></p><p><list list-type="order"><title>Funding for Travel or Speaker Honoraria:</title><list-item><p>(1) Dystonia Medical Research Foundation, (2) Movement Disorders Society</p></list-item></list></p><p><list list-type="order"><title>Editorial Boards:</title><list-item><p>NONE</p></list-item></list></p><p><list list-type="order"><title>Patents:</title><list-item><p>NONE</p></list-item></list></p><p><list list-type="order"><title>Publishing Royalties:</title><list-item><p>NONE</p></list-item></list></p><p><list list-type="order"><title>Employment, Commercial Entity:</title><list-item><p>NONE</p></list-item></list></p><p><list list-type="order"><title>Consultancies:</title><list-item><p>(1) Medtronic, Inc.</p></list-item></list></p><p><list list-type="order"><title>Speakers' Bureaus:</title><list-item><p>NONE</p></list-item></list></p><p><list list-type="order"><title>Other Activities:</title><list-item><p>NONE</p></list-item></list></p><p><list list-type="order"><title>Clinical Procedures or Imaging Studies:</title><list-item><p>Botulinum toxin injections as a clinical service</p></list-item></list></p><p><list list-type="order"><title>Research Support, Commercial Entities:</title><list-item><p>(1) Psyadon Pharmaceuticals (2) Merz Pharmaceuticals (3) IPSEN Pharmaceuticals</p></list-item></list></p><p><list list-type="order"><title>Research Support, Government Entities:</title><list-item><p>PI: NINDS NS065701, TR001456</p></list-item></list></p><p><list list-type="order"><title>Research Support, Academic Entities:</title><list-item><p>(1) Emory Neurosciences Initiative (2) Atlanta Clinical and Translational Institute (3) Emory University Research Council</p></list-item></list></p><p><list list-type="order"><title>Research Support, Foundations and Societies:</title><list-item><p>(1) Dystonia Medical Research Foundation (3) Lesch-Nyhan Syndrome Children's Research Foundation (4) Cure Dystonia Now (5) Dystonia Coalition (6) Benign Essential Blepharospasm Research Foundation</p></list-item></list></p><p><list list-type="order"><title>Stock/Stock Options/Board of Directors Compensation:</title><list-item><p>NONE</p></list-item></list></p><p><list list-type="order"><title>License Fee Payments, Technology or Inventions:</title><list-item><p>NONE</p></list-item></list></p><p><list list-type="order"><title>Royalty Payments, Technology or Inventions:</title><list-item><p>NONE</p></list-item></list></p><p><list list-type="order"><title>Stock/Stock Options, Research Sponsor:</title><list-item><p>NONE</p></list-item></list></p><p><list list-type="order"><title>Stock/Stock Options, Medical Equipment & Materials:</title><list-item><p>NONE</p></list-item></list></p><p><list list-type="order"><title>Legal Proceedings:</title><list-item><p>NONE</p></list-item></list></p></author-comment></contrib><contrib contrib-type="author"><name><surname>Rosen</surname><given-names>Ami R.</given-names></name><degrees>MS</degrees><author-comment content-type="disclosure"><p><list list-type="order"><title>Scientific Advisory Boards:</title><list-item><p>NONE</p></list-item></list></p><p><list list-type="order"><title>Gifts:</title><list-item><p>NONE</p></list-item></list></p><p><list list-type="order"><title>Funding for Travel or Speaker Honoraria:</title><list-item><p>NONE</p></list-item></list></p><p><list list-type="order"><title>Editorial Boards:</title><list-item><p>NONE</p></list-item></list></p><p><list list-type="order"><title>Patents:</title><list-item><p>NONE</p></list-item></list></p><p><list list-type="order"><title>Publishing Royalties:</title><list-item><p>NONE</p></list-item></list></p><p><list list-type="order"><title>Employment, Commercial Entity:</title><list-item><p>NONE</p></list-item></list></p><p><list list-type="order"><title>Consultancies:</title><list-item><p>NONE</p></list-item></list></p><p><list list-type="order"><title>Speakers' Bureaus:</title><list-item><p>NONE</p></list-item></list></p><p><list list-type="order"><title>Other Activities:</title><list-item><p>NONE</p></list-item></list></p><p><list list-type="order"><title>Clinical Procedures or Imaging Studies:</title><list-item><p>NONE</p></list-item></list></p><p><list list-type="order"><title>Research Support, Commercial Entities:</title><list-item><p>NONE</p></list-item></list></p><p><list list-type="order"><title>Research Support, Government Entities:</title><list-item><p>NONE</p></list-item></list></p><p><list list-type="order"><title>Research Support, Academic Entities:</title><list-item><p>NONE</p></list-item></list></p><p><list list-type="order"><title>Research Support, Foundations and Societies:</title><list-item><p>NONE</p></list-item></list></p><p><list list-type="order"><title>Stock/Stock Options/Board of Directors Compensation:</title><list-item><p>NONE</p></list-item></list></p><p><list list-type="order"><title>License Fee Payments, Technology or Inventions:</title><list-item><p>NONE</p></list-item></list></p><p><list list-type="order"><title>Royalty Payments, Technology or Inventions:</title><list-item><p>NONE</p></list-item></list></p><p><list list-type="order"><title>Stock/Stock Options, Research Sponsor:</title><list-item><p>NONE</p></list-item></list></p><p><list list-type="order"><title>Stock/Stock Options, Medical Equipment & Materials:</title><list-item><p>NONE</p></list-item></list></p><p><list list-type="order"><title>Legal Proceedings:</title><list-item><p>NONE</p></list-item></list></p></author-comment></contrib><contrib contrib-type="author"><name><surname>Hedera</surname><given-names>Peter</given-names></name><degrees>MD, PhD</degrees><author-comment content-type="disclosure"><p><list list-type="order"><title>Scientific Advisory Boards:</title><list-item><p>NONE</p></list-item></list></p><p><list list-type="order"><title>Gifts:</title><list-item><p>NONE</p></list-item></list></p><p><list list-type="order"><title>Funding for Travel or Speaker Honoraria:</title><list-item><p>NONE</p></list-item></list></p><p><list list-type="order"><title>Editorial Boards:</title><list-item><p>Journal of Parkinsonism and restless leg syndrome - editor-in-chief 2015-present Neurology - member of editorial board 2012-present Parkinsonism and related disorders- member of editorial board 2010-present</p></list-item></list></p><p><list list-type="order"><title>Patents:</title><list-item><p>NONE</p></list-item></list></p><p><list list-type="order"><title>Publishing Royalties:</title><list-item><p>NONE</p></list-item></list></p><p><list list-type="order"><title>Employment, Commercial Entity:</title><list-item><p>NONE</p></list-item></list></p><p><list list-type="order"><title>Consultancies:</title><list-item><p>NONE</p></list-item></list></p><p><list list-type="order"><title>Speakers' Bureaus:</title><list-item><p>NONE</p></list-item></list></p><p><list list-type="order"><title>Other Activities:</title><list-item><p>NONE</p></list-item></list></p><p><list list-type="order"><title>Clinical Procedures or Imaging Studies:</title><list-item><p>NONE</p></list-item></list></p><p><list list-type="order"><title>Research Support, Commercial Entities:</title><list-item><p>NONE</p></list-item></list></p><p><list list-type="order"><title>Research Support, Government Entities:</title><list-item><p>NONE</p></list-item></list></p><p><list list-type="order"><title>Research Support, Academic Entities:</title><list-item><p>NONE</p></list-item></list></p><p><list list-type="order"><title>Research Support, Foundations and Societies:</title><list-item><p>NONE</p></list-item></list></p><p><list list-type="order"><title>Stock/Stock Options/Board of Directors Compensation:</title><list-item><p>NONE</p></list-item></list></p><p><list list-type="order"><title>License Fee Payments, Technology or Inventions:</title><list-item><p>NONE</p></list-item></list></p><p><list list-type="order"><title>Royalty Payments, Technology or Inventions:</title><list-item><p>NONE</p></list-item></list></p><p><list list-type="order"><title>Stock/Stock Options, Research Sponsor:</title><list-item><p>NONE</p></list-item></list></p><p><list list-type="order"><title>Stock/Stock Options, Medical Equipment & Materials:</title><list-item><p>NONE</p></list-item></list></p><p><list list-type="order"><title>Legal Proceedings:</title><list-item><p>NONE</p></list-item></list></p></author-comment></contrib><contrib contrib-type="author"><name><surname>Comella</surname><given-names>Cynthia L.</given-names></name><degrees>MD</degrees><author-comment content-type="disclosure"><p><list list-type="order"><title>Scientific Advisory Boards:</title><list-item><p>1. Commercial: Acorda Therapeutics, Allergan, Inc; Impax Pharmaceuticals; Ipsen Biopharmaceuticals, Inc; Lundbeck Ltd.;Medtronic Inc.; Merz Pharmaceuticals;Acadia Pharmaceuticals; Teva Neurosciences; Neurocrine Biosciences Inc., Revance Therapeutic; and Ultragenyx Pharmaceuticals.</p></list-item></list></p><p><list list-type="order"><title>Gifts:</title><list-item><p>NONE</p></list-item></list></p><p><list list-type="order"><title>Funding for Travel or Speaker Honoraria:</title><list-item><p>NONE</p></list-item></list></p><p><list list-type="order"><title>Editorial Boards:</title><list-item><p>Sleep Medicine editorial board for 6 years Clinical Neuropharmacology for 8 years</p></list-item></list></p><p><list list-type="order"><title>Patents:</title><list-item><p>NONE</p></list-item></list></p><p><list list-type="order"><title>Publishing Royalties:</title><list-item><p>Uptodate (Kluwer Bucy) Cambridge publishing</p></list-item></list></p><p><list list-type="order"><title>Employment, Commercial Entity:</title><list-item><p>NONE</p></list-item></list></p><p><list list-type="order"><title>Consultancies:</title><list-item><p>Commercial: Acorda Therapeutics, Allergan, Inc; Impax Pharmaceuticals; Ipsen Biopharmaceuticals, Inc; Lundbeck Ltd.;Medtronic Inc.; Merz Pharmaceuticals;Acadia Pharmaceuticals; Teva Neurosciences; Neurocrine Biosciences Inc., Revance Therapeutic; and Ultragenyx Pharmaceuticals.</p></list-item></list></p><p><list list-type="order"><title>Speakers' Bureaus:</title><list-item><p>NONE</p></list-item></list></p><p><list list-type="order"><title>Other Activities:</title><list-item><p>NONE</p></list-item></list></p><p><list list-type="order"><title>Clinical Procedures or Imaging Studies:</title><list-item><p>NONE</p></list-item></list></p><p><list list-type="order"><title>Research Support, Commercial Entities:</title><list-item><p>Commercial: Allergan, Ipsen, Merz, Biotie, Revance</p></list-item></list></p><p><list list-type="order"><title>Research Support, Government Entities:</title><list-item><p>NIH NIH R01NS074343, U54NS065701</p></list-item></list></p><p><list list-type="order"><title>Research Support, Academic Entities:</title><list-item><p>NONE</p></list-item></list></p><p><list list-type="order"><title>Research Support, Foundations and Societies:</title><list-item><p>Dystonia Coalition (see above)</p></list-item></list></p><p><list list-type="order"><title>Stock/Stock Options/Board of Directors Compensation:</title><list-item><p>NONE</p></list-item></list></p><p><list list-type="order"><title>License Fee Payments, Technology or Inventions:</title><list-item><p>NONE</p></list-item></list></p><p><list list-type="order"><title>Royalty Payments, Technology or Inventions:</title><list-item><p>NONE</p></list-item></list></p><p><list list-type="order"><title>Stock/Stock Options, Research Sponsor:</title><list-item><p>NONE</p></list-item></list></p><p><list list-type="order"><title>Stock/Stock Options, Medical Equipment & Materials:</title><list-item><p>NONE</p></list-item></list></p><p><list list-type="order"><title>Legal Proceedings:</title><list-item><p>NONE</p></list-item></list></p></author-comment></contrib><contrib contrib-type="author"><name><surname>Weissbach</surname><given-names>Anne</given-names></name><degrees>MD</degrees><author-comment content-type="disclosure"><p><list list-type="order"><title>Scientific Advisory Boards:</title><list-item><p>NONE</p></list-item></list></p><p><list list-type="order"><title>Gifts:</title><list-item><p>NONE</p></list-item></list></p><p><list list-type="order"><title>Funding for Travel or Speaker Honoraria:</title><list-item><p>NONE</p></list-item></list></p><p><list list-type="order"><title>Editorial Boards:</title><list-item><p>NONE</p></list-item></list></p><p><list list-type="order"><title>Patents:</title><list-item><p>NONE</p></list-item></list></p><p><list list-type="order"><title>Publishing Royalties:</title><list-item><p>NONE</p></list-item></list></p><p><list list-type="order"><title>Employment, Commercial Entity:</title><list-item><p>NONE</p></list-item></list></p><p><list list-type="order"><title>Consultancies:</title><list-item><p>NONE</p></list-item></list></p><p><list list-type="order"><title>Speakers' Bureaus:</title><list-item><p>NONE</p></list-item></list></p><p><list list-type="order"><title>Other Activities:</title><list-item><p>NONE</p></list-item></list></p><p><list list-type="order"><title>Clinical Procedures or Imaging Studies:</title><list-item><p>NONE</p></list-item></list></p><p><list list-type="order"><title>Research Support, Commercial Entities:</title><list-item><p>NONE</p></list-item></list></p><p><list list-type="order"><title>Research Support, Government Entities:</title><list-item><p>NONE</p></list-item></list></p><p><list list-type="order"><title>Research Support, Academic Entities:</title><list-item><p>NONE</p></list-item></list></p><p><list list-type="order"><title>Research Support, Foundations and Societies:</title><list-item><p>NONE</p></list-item></list></p><p><list list-type="order"><title>Stock/Stock Options/Board of Directors Compensation:</title><list-item><p>NONE</p></list-item></list></p><p><list list-type="order"><title>License Fee Payments, Technology or Inventions:</title><list-item><p>NONE</p></list-item></list></p><p><list list-type="order"><title>Royalty Payments, Technology or Inventions:</title><list-item><p>NONE</p></list-item></list></p><p><list list-type="order"><title>Stock/Stock Options, Research Sponsor:</title><list-item><p>NONE</p></list-item></list></p><p><list list-type="order"><title>Stock/Stock Options, Medical Equipment & Materials:</title><list-item><p>NONE</p></list-item></list></p><p><list list-type="order"><title>Legal Proceedings:</title><list-item><p>NONE</p></list-item></list></p></author-comment></contrib><contrib contrib-type="author"><name><surname>Junker</surname><given-names>Johanna</given-names></name><degrees>MD</degrees><author-comment content-type="disclosure"><p><list list-type="order"><title>Scientific Advisory Boards:</title><list-item><p>NONE</p></list-item></list></p><p><list list-type="order"><title>Gifts:</title><list-item><p>NONE</p></list-item></list></p><p><list list-type="order"><title>Funding for Travel or Speaker Honoraria:</title><list-item><p>NONE</p></list-item></list></p><p><list list-type="order"><title>Editorial Boards:</title><list-item><p>NONE</p></list-item></list></p><p><list list-type="order"><title>Patents:</title><list-item><p>NONE</p></list-item></list></p><p><list list-type="order"><title>Publishing Royalties:</title><list-item><p>NONE</p></list-item></list></p><p><list list-type="order"><title>Employment, Commercial Entity:</title><list-item><p>NONE</p></list-item></list></p><p><list list-type="order"><title>Consultancies:</title><list-item><p>NONE</p></list-item></list></p><p><list list-type="order"><title>Speakers' Bureaus:</title><list-item><p>NONE</p></list-item></list></p><p><list list-type="order"><title>Other Activities:</title><list-item><p>NONE</p></list-item></list></p><p><list list-type="order"><title>Clinical Procedures or Imaging Studies:</title><list-item><p>NONE</p></list-item></list></p><p><list list-type="order"><title>Research Support, Commercial Entities:</title><list-item><p>NONE</p></list-item></list></p><p><list list-type="order"><title>Research Support, Government Entities:</title><list-item><p>NONE</p></list-item></list></p><p><list list-type="order"><title>Research Support, Academic Entities:</title><list-item><p>NONE</p></list-item></list></p><p><list list-type="order"><title>Research Support, Foundations and Societies:</title><list-item><p>NONE</p></list-item></list></p><p><list list-type="order"><title>Stock/Stock Options/Board of Directors Compensation:</title><list-item><p>NONE</p></list-item></list></p><p><list list-type="order"><title>License Fee Payments, Technology or Inventions:</title><list-item><p>NONE</p></list-item></list></p><p><list list-type="order"><title>Royalty Payments, Technology or Inventions:</title><list-item><p>NONE</p></list-item></list></p><p><list list-type="order"><title>Stock/Stock Options, Research Sponsor:</title><list-item><p>NONE</p></list-item></list></p><p><list list-type="order"><title>Stock/Stock Options, Medical Equipment & Materials:</title><list-item><p>NONE</p></list-item></list></p><p><list list-type="order"><title>Legal Proceedings:</title><list-item><p>NONE</p></list-item></list></p></author-comment></contrib><contrib contrib-type="author"><name><surname>Jankovic</surname><given-names>Joseph</given-names></name><degrees>MD</degrees><author-comment content-type="disclosure"><p><list list-type="order"><title>Scientific Advisory Boards:</title><list-item><p>Adamas Pharmaceuticals, Inc; Allergan, Inc; Teva Pharmaceutical Industries Ltd</p></list-item></list></p><p><list list-type="order"><title>Gifts:</title><list-item><p>Adamas Pharmaceuticals, Inc; Allergan, Inc; Teva Pharmaceutical Industries Ltd</p></list-item></list></p><p><list list-type="order"><title>Funding for Travel or Speaker Honoraria:</title><list-item><p>Adamas Pharmaceuticals, Inc; Allergan, Inc; Teva Pharmaceutical Industries Ltd</p></list-item></list></p><p><list list-type="order"><title>Editorial Boards:</title><list-item><p>Acta Neurologica Scandinavica, Journal of the Neurological Sciences, Neurology Medlink, Neurotherapeutics, Expert Review of Neurotherapeutics, Journal of Parkinson?s Disease, Toxins</p></list-item></list></p><p><list list-type="order"><title>Patents:</title><list-item><p>NONE</p></list-item></list></p><p><list list-type="order"><title>Publishing Royalties:</title><list-item><p>Cambridge; Elsevier; Future Science Group; Hodder Arnold; Lippincott Williams and Wilkins; Wiley-Blackwell</p></list-item></list></p><p><list list-type="order"><title>Employment, Commercial Entity:</title><list-item><p>NONE</p></list-item></list></p><p><list list-type="order"><title>Consultancies:</title><list-item><p>Adamas Pharmaceuticals, Inc; Allergan, Inc; Teva Pharmaceutical Industries Ltd</p></list-item></list></p><p><list list-type="order"><title>Speakers' Bureaus:</title><list-item><p>NONE</p></list-item></list></p><p><list list-type="order"><title>Other Activities:</title><list-item><p>NONE</p></list-item></list></p><p><list list-type="order"><title>Clinical Procedures or Imaging Studies:</title><list-item><p>NONE</p></list-item></list></p><p><list list-type="order"><title>Research Support, Commercial Entities:</title><list-item><p>Adamas Pharmaceuticals, Inc; Allergan, Inc; CHDI Foundation; Civitas/Acorda Therapeutics; Huntington Study Group; Ipsen Limited; Kyowa Haako Kirin Pharma, Inc; Lundbeck Inc; Medtronic; Merz Pharmaceuticals; Michael J Fox Foundation for Parkinson Research; National Institutes of Health; National Parkinson Foundation; Parkinson Study Group; Pfizer; Prothena Biosciences Inc; Psyadon Pharmaceuticals, Inc; St. Jude Medical; Teva Pharmaceutical Industries Ltd.</p></list-item></list></p><p><list list-type="order"><title>Research Support, Government Entities:</title><list-item><p>NONE</p></list-item></list></p><p><list list-type="order"><title>Research Support, Academic Entities:</title><list-item><p>NONE</p></list-item></list></p><p><list list-type="order"><title>Research Support, Foundations and Societies:</title><list-item><p>NONE</p></list-item></list></p><p><list list-type="order"><title>Stock/Stock Options/Board of Directors Compensation:</title><list-item><p>NONE</p></list-item></list></p><p><list list-type="order"><title>License Fee Payments, Technology or Inventions:</title><list-item><p>NONE</p></list-item></list></p><p><list list-type="order"><title>Royalty Payments, Technology or Inventions:</title><list-item><p>NONE</p></list-item></list></p><p><list list-type="order"><title>Stock/Stock Options, Research Sponsor:</title><list-item><p>NONE</p></list-item></list></p><p><list list-type="order"><title>Stock/Stock Options, Medical Equipment & Materials:</title><list-item><p>NONE</p></list-item></list></p><p><list list-type="order"><title>Legal Proceedings:</title><list-item><p>NONE</p></list-item></list></p></author-comment></contrib><contrib contrib-type="author"><name><surname>Barbano</surname><given-names>Richard L.</given-names></name><degrees>MD, PhD</degrees><author-comment content-type="disclosure"><p><list list-type="order"><title>Scientific Advisory Boards:</title><list-item><p>NONE</p></list-item></list></p><p><list list-type="order"><title>Gifts:</title><list-item><p>NONE</p></list-item></list></p><p><list list-type="order"><title>Funding for Travel or Speaker Honoraria:</title><list-item><p>NONE</p></list-item></list></p><p><list list-type="order"><title>Editorial Boards:</title><list-item><p>Neurology Clinical Practice, Associate editor, 2011-present</p></list-item></list></p><p><list list-type="order"><title>Patents:</title><list-item><p>NONE</p></list-item></list></p><p><list list-type="order"><title>Publishing Royalties:</title><list-item><p>NONE</p></list-item></list></p><p><list list-type="order"><title>Employment, Commercial Entity:</title><list-item><p>NONE</p></list-item></list></p><p><list list-type="order"><title>Consultancies:</title><list-item><p>NONE</p></list-item></list></p><p><list list-type="order"><title>Speakers' Bureaus:</title><list-item><p>NONE</p></list-item></list></p><p><list list-type="order"><title>Other Activities:</title><list-item><p>NONE</p></list-item></list></p><p><list list-type="order"><title>Clinical Procedures or Imaging Studies:</title><list-item><p>University of Rochester, botulinum toxin injections, 30% effort, since 1994</p></list-item></list></p><p><list list-type="order"><title>Research Support, Commercial Entities:</title><list-item><p>1.CD Probe study, funded by Allergan 2. Vaccinex 3.Biotie</p></list-item></list></p><p><list list-type="order"><title>Research Support, Government Entities:</title><list-item><p>NIH, NINDS, ORDR: Dystonia Coalition Projects, Site PI</p></list-item></list></p><p><list list-type="order"><title>Research Support, Academic Entities:</title><list-item><p>NONE</p></list-item></list></p><p><list list-type="order"><title>Research Support, Foundations and Societies:</title><list-item><p>NONE</p></list-item></list></p><p><list list-type="order"><title>Stock/Stock Options/Board of Directors Compensation:</title><list-item><p>NONE</p></list-item></list></p><p><list list-type="order"><title>License Fee Payments, Technology or Inventions:</title><list-item><p>NONE</p></list-item></list></p><p><list list-type="order"><title>Royalty Payments, Technology or Inventions:</title><list-item><p>NONE</p></list-item></list></p><p><list list-type="order"><title>Stock/Stock Options, Research Sponsor:</title><list-item><p>NONE</p></list-item></list></p><p><list list-type="order"><title>Stock/Stock Options, Medical Equipment & Materials:</title><list-item><p>VisualDx, 2014-present</p></list-item></list></p><p><list list-type="order"><title>Legal Proceedings:</title><list-item><p>Expert witness in legal proceedings including malpractice, but NOT involving commercial entities</p></list-item></list></p></author-comment></contrib><contrib contrib-type="author"><name><surname>Reich</surname><given-names>Stephen G.</given-names></name><degrees>MD</degrees><author-comment content-type="disclosure"><p><list list-type="order"><title>Scientific Advisory Boards:</title><list-item><p>NONE</p></list-item></list></p><p><list list-type="order"><title>Gifts:</title><list-item><p>NONE</p></list-item></list></p><p><list list-type="order"><title>Funding for Travel or Speaker Honoraria:</title><list-item><p>NONE</p></list-item></list></p><p><list list-type="order"><title>Editorial Boards:</title><list-item><p>Associate Editor, Journal of Clinical Movement Disorders (no compensation); 2015-Editorial board member (no compensation): Parkinsonism and Related Movement Disorders (2014-</p></list-item></list></p><p><list list-type="order"><title>Patents:</title><list-item><p>NONE</p></list-item></list></p><p><list list-type="order"><title>Publishing Royalties:</title><list-item><p>Royalties from Informa for: Reich SG. Movement Disorders: 100 Instructive Cases.</p></list-item></list></p><p><list list-type="order"><title>Employment, Commercial Entity:</title><list-item><p>NONE</p></list-item></list></p><p><list list-type="order"><title>Consultancies:</title><list-item><p>NONE</p></list-item></list></p><p><list list-type="order"><title>Speakers' Bureaus:</title><list-item><p>NONE</p></list-item></list></p><p><list list-type="order"><title>Other Activities:</title><list-item><p>NONE</p></list-item></list></p><p><list list-type="order"><title>Clinical Procedures or Imaging Studies:</title><list-item><p>NONE</p></list-item></list></p><p><list list-type="order"><title>Research Support, Commercial Entities:</title><list-item><p>NONE</p></list-item></list></p><p><list list-type="order"><title>Research Support, Government Entities:</title><list-item><p>1.NINDS (site PI)</p></list-item></list></p><p><list list-type="order"><title>Research Support, Academic Entities:</title><list-item><p>NONE</p></list-item></list></p><p><list list-type="order"><title>Research Support, Foundations and Societies:</title><list-item><p>NONE</p></list-item></list></p><p><list list-type="order"><title>Stock/Stock Options/Board of Directors Compensation:</title><list-item><p>NONE</p></list-item></list></p><p><list list-type="order"><title>License Fee Payments, Technology or Inventions:</title><list-item><p>NONE</p></list-item></list></p><p><list list-type="order"><title>Royalty Payments, Technology or Inventions:</title><list-item><p>NONE</p></list-item></list></p><p><list list-type="order"><title>Stock/Stock Options, Research Sponsor:</title><list-item><p>NONE</p></list-item></list></p><p><list list-type="order"><title>Stock/Stock Options, Medical Equipment & Materials:</title><list-item><p>NONE</p></list-item></list></p><p><list list-type="order"><title>Legal Proceedings:</title><list-item><p>NONE</p></list-item></list></p></author-comment></contrib><contrib contrib-type="author"><name><surname>Rodriguez</surname><given-names>Ramon L.</given-names></name><degrees>MD</degrees><author-comment content-type="disclosure"><p><list list-type="order"><title>Scientific Advisory Boards:</title><list-item><p>Serving on Advisory Board for Teva Pharmaceuticals, Auspex Pharmaceuticals, Lundbeck, Abbvie. Speaker Bureau for Allergan and Abbvie.</p></list-item></list></p><p><list list-type="order"><title>Gifts:</title><list-item><p>NONE</p></list-item></list></p><p><list list-type="order"><title>Funding for Travel or Speaker Honoraria:</title><list-item><p>NONE</p></list-item></list></p><p><list list-type="order"><title>Editorial Boards:</title><list-item><p>NONE</p></list-item></list></p><p><list list-type="order"><title>Patents:</title><list-item><p>NONE</p></list-item></list></p><p><list list-type="order"><title>Publishing Royalties:</title><list-item><p>NONE</p></list-item></list></p><p><list list-type="order"><title>Employment, Commercial Entity:</title><list-item><p>NONE</p></list-item></list></p><p><list list-type="order"><title>Consultancies:</title><list-item><p>NONE</p></list-item></list></p><p><list list-type="order"><title>Speakers' Bureaus:</title><list-item><p>Abbvie and Allergan.</p></list-item></list></p><p><list list-type="order"><title>Other Activities:</title><list-item><p>NONE</p></list-item></list></p><p><list list-type="order"><title>Clinical Procedures or Imaging Studies:</title><list-item><p>NONE</p></list-item></list></p><p><list list-type="order"><title>Research Support, Commercial Entities:</title><list-item><p>NONE</p></list-item></list></p><p><list list-type="order"><title>Research Support, Government Entities:</title><list-item><p>NONE</p></list-item></list></p><p><list list-type="order"><title>Research Support, Academic Entities:</title><list-item><p>NONE</p></list-item></list></p><p><list list-type="order"><title>Research Support, Foundations and Societies:</title><list-item><p>NONE</p></list-item></list></p><p><list list-type="order"><title>Stock/Stock Options/Board of Directors Compensation:</title><list-item><p>NONE</p></list-item></list></p><p><list list-type="order"><title>License Fee Payments, Technology or Inventions:</title><list-item><p>NONE</p></list-item></list></p><p><list list-type="order"><title>Royalty Payments, Technology or Inventions:</title><list-item><p>NONE</p></list-item></list></p><p><list list-type="order"><title>Stock/Stock Options, Research Sponsor:</title><list-item><p>NONE</p></list-item></list></p><p><list list-type="order"><title>Stock/Stock Options, Medical Equipment & Materials:</title><list-item><p>NONE</p></list-item></list></p><p><list list-type="order"><title>Legal Proceedings:</title><list-item><p>NONE</p></list-item></list></p></author-comment></contrib><contrib contrib-type="author"><name><surname>Berman</surname><given-names>Brian D.</given-names></name><degrees>MD</degrees><author-comment content-type="disclosure"><p><list list-type="order"><title>Scientific Advisory Boards:</title><list-item><p>(1) Benign Essential Blepharospasm Research Foundation (2) National Spasmodic Torticollis Association</p></list-item></list></p><p><list list-type="order"><title>Gifts:</title><list-item><p>NONE</p></list-item></list></p><p><list list-type="order"><title>Funding for Travel or Speaker Honoraria:</title><list-item><p>(1) Parkinson Study Group, funding for travel to conference (2) American Neurological Association, funding for travel to conference (3) Movement Disorder Society, funding for travel to conference (4) Dystonia Medical Research Foundation, funding for travel to conference (5) Benign Essential Blepharospasm Research Foundation, funding for travel to conference</p></list-item></list></p><p><list list-type="order"><title>Editorial Boards:</title><list-item><p>(1) Journal of Neurology and Neurophysiology, Editorial Board Member, 2011-2015</p></list-item></list></p><p><list list-type="order"><title>Patents:</title><list-item><p>NONE</p></list-item></list></p><p><list list-type="order"><title>Publishing Royalties:</title><list-item><p>NONE</p></list-item></list></p><p><list list-type="order"><title>Employment, Commercial Entity:</title><list-item><p>NONE</p></list-item></list></p><p><list list-type="order"><title>Consultancies:</title><list-item><p>NONE</p></list-item></list></p><p><list list-type="order"><title>Speakers' Bureaus:</title><list-item><p>NONE</p></list-item></list></p><p><list list-type="order"><title>Other Activities:</title><list-item><p>NONE</p></list-item></list></p><p><list list-type="order"><title>Clinical Procedures or Imaging Studies:</title><list-item><p>NONE</p></list-item></list></p><p><list list-type="order"><title>Research Support, Commercial Entities:</title><list-item><p>NONE</p></list-item></list></p><p><list list-type="order"><title>Research Support, Government Entities:</title><list-item><p>(1) NIH/CTSA, 5 KL2 TR 1080-2, Principal investigator, 2014-2017 (2) NIH, R01 NS074343, Co-investigator, 2011-2015 (3) NIH, U54NS065701, Dystonia Coalition Site principal investigator, 2011-2016 (4) NIH, U54NS065701 Career Development Award, Principal investigator, 2012-2014</p></list-item></list></p><p><list list-type="order"><title>Research Support, Academic Entities:</title><list-item><p>(1) Colorado Translational Research Imaging Center (2) University of Colorado Center for Neuroscience</p></list-item></list></p><p><list list-type="order"><title>Research Support, Foundations and Societies:</title><list-item><p>(1) The Dana Foundation (The David Mahoney Neuroimaging Program) (2) Benign Essential Blepharospasm Research Foundation, Inc. (Research Grant) (3) Dystonia Medical Research Foundation (Career Development Award)</p></list-item></list></p><p><list list-type="order"><title>Stock/Stock Options/Board of Directors Compensation:</title><list-item><p>NONE</p></list-item></list></p><p><list list-type="order"><title>License Fee Payments, Technology or Inventions:</title><list-item><p>NONE</p></list-item></list></p><p><list list-type="order"><title>Royalty Payments, Technology or Inventions:</title><list-item><p>NONE</p></list-item></list></p><p><list list-type="order"><title>Stock/Stock Options, Research Sponsor:</title><list-item><p>NONE</p></list-item></list></p><p><list list-type="order"><title>Stock/Stock Options, Medical Equipment & Materials:</title><list-item><p>NONE</p></list-item></list></p><p><list list-type="order"><title>Legal Proceedings:</title><list-item><p>NONE</p></list-item></list></p></author-comment></contrib><contrib contrib-type="author"><name><surname>Chouinard</surname><given-names>Sylvain</given-names></name><degrees>MD</degrees><author-comment content-type="disclosure"><p><list list-type="order"><title>Scientific Advisory Boards:</title><list-item><p>NONE</p></list-item></list></p><p><list list-type="order"><title>Gifts:</title><list-item><p>NONE</p></list-item></list></p><p><list list-type="order"><title>Funding for Travel or Speaker Honoraria:</title><list-item><p>Allergan, Merz</p></list-item></list></p><p><list list-type="order"><title>Editorial Boards:</title><list-item><p>NONE</p></list-item></list></p><p><list list-type="order"><title>Patents:</title><list-item><p>NONE</p></list-item></list></p><p><list list-type="order"><title>Publishing Royalties:</title><list-item><p>NONE</p></list-item></list></p><p><list list-type="order"><title>Employment, Commercial Entity:</title><list-item><p>NONE</p></list-item></list></p><p><list list-type="order"><title>Consultancies:</title><list-item><p>NONE</p></list-item></list></p><p><list list-type="order"><title>Speakers' Bureaus:</title><list-item><p>NONE</p></list-item></list></p><p><list list-type="order"><title>Other Activities:</title><list-item><p>NONE</p></list-item></list></p><p><list list-type="order"><title>Clinical Procedures or Imaging Studies:</title><list-item><p>NONE</p></list-item></list></p><p><list list-type="order"><title>Research Support, Commercial Entities:</title><list-item><p>NONE</p></list-item></list></p><p><list list-type="order"><title>Research Support, Government Entities:</title><list-item><p>NONE</p></list-item></list></p><p><list list-type="order"><title>Research Support, Academic Entities:</title><list-item><p>NONE</p></list-item></list></p><p><list list-type="order"><title>Research Support, Foundations and Societies:</title><list-item><p>NONE</p></list-item></list></p><p><list list-type="order"><title>Stock/Stock Options/Board of Directors Compensation:</title><list-item><p>NONE</p></list-item></list></p><p><list list-type="order"><title>License Fee Payments, Technology or Inventions:</title><list-item><p>NONE</p></list-item></list></p><p><list list-type="order"><title>Royalty Payments, Technology or Inventions:</title><list-item><p>NONE</p></list-item></list></p><p><list list-type="order"><title>Stock/Stock Options, Research Sponsor:</title><list-item><p>NONE</p></list-item></list></p><p><list list-type="order"><title>Stock/Stock Options, Medical Equipment & Materials:</title><list-item><p>NONE</p></list-item></list></p><p><list list-type="order"><title>Legal Proceedings:</title><list-item><p>NONE</p></list-item></list></p></author-comment></contrib><contrib contrib-type="author"><name><surname>Severt</surname><given-names>Lawrence</given-names></name><degrees>MD, PhD</degrees><author-comment content-type="disclosure"><p><list list-type="order"><title>Scientific Advisory Boards:</title><list-item><p>Lundbeck Droxidopa Advisory Board</p></list-item></list></p><p><list list-type="order"><title>Gifts:</title><list-item><p>NONE</p></list-item></list></p><p><list list-type="order"><title>Funding for Travel or Speaker Honoraria:</title><list-item><p>Teva Neuroscience Speaking Honorarium Allergan Speaking Honorarium Lundbeck Speaking Honorarium Impax Speaking Honorarium</p></list-item></list></p><p><list list-type="order"><title>Editorial Boards:</title><list-item><p>NONE</p></list-item></list></p><p><list list-type="order"><title>Patents:</title><list-item><p>NONE</p></list-item></list></p><p><list list-type="order"><title>Publishing Royalties:</title><list-item><p>NONE</p></list-item></list></p><p><list list-type="order"><title>Employment, Commercial Entity:</title><list-item><p>NONE</p></list-item></list></p><p><list list-type="order"><title>Consultancies:</title><list-item><p>NONE</p></list-item></list></p><p><list list-type="order"><title>Speakers' Bureaus:</title><list-item><p>Teva Neuroscience Speaking Honorarium Allergan Speaking Honorarium Lundbeck Speaking Honorarium Impax Speaking Honorarium</p></list-item></list></p><p><list list-type="order"><title>Other Activities:</title><list-item><p>NONE</p></list-item></list></p><p><list list-type="order"><title>Clinical Procedures or Imaging Studies:</title><list-item><p>NONE</p></list-item></list></p><p><list list-type="order"><title>Research Support, Commercial Entities:</title><list-item><p>US Worldmeds</p></list-item></list></p><p><list list-type="order"><title>Research Support, Government Entities:</title><list-item><p>NONE</p></list-item></list></p><p><list list-type="order"><title>Research Support, Academic Entities:</title><list-item><p>NONE</p></list-item></list></p><p><list list-type="order"><title>Research Support, Foundations and Societies:</title><list-item><p>NONE</p></list-item></list></p><p><list list-type="order"><title>Stock/Stock Options/Board of Directors Compensation:</title><list-item><p>NONE</p></list-item></list></p><p><list list-type="order"><title>License Fee Payments, Technology or Inventions:</title><list-item><p>NONE</p></list-item></list></p><p><list list-type="order"><title>Royalty Payments, Technology or Inventions:</title><list-item><p>NONE</p></list-item></list></p><p><list list-type="order"><title>Stock/Stock Options, Research Sponsor:</title><list-item><p>NONE</p></list-item></list></p><p><list list-type="order"><title>Stock/Stock Options, Medical Equipment & Materials:</title><list-item><p>NONE</p></list-item></list></p><p><list list-type="order"><title>Legal Proceedings:</title><list-item><p>NONE</p></list-item></list></p></author-comment></contrib><contrib contrib-type="author"><name><surname>Agarwal</surname><given-names>Pinky</given-names></name><degrees>MD</degrees><author-comment content-type="disclosure"><p><list list-type="order"><title>Scientific Advisory Boards:</title><list-item><p>NONE</p></list-item></list></p><p><list list-type="order"><title>Gifts:</title><list-item><p>NONE</p></list-item></list></p><p><list list-type="order"><title>Funding for Travel or Speaker Honoraria:</title><list-item><p>Speaker for Teva, UCB, US world meds, Impax,Lundbeck</p></list-item></list></p><p><list list-type="order"><title>Editorial Boards:</title><list-item><p>NONE</p></list-item></list></p><p><list list-type="order"><title>Patents:</title><list-item><p>NONE</p></list-item></list></p><p><list list-type="order"><title>Publishing Royalties:</title><list-item><p>NONE</p></list-item></list></p><p><list list-type="order"><title>Employment, Commercial Entity:</title><list-item><p>NONE</p></list-item></list></p><p><list list-type="order"><title>Consultancies:</title><list-item><p>Advisory board for Cynapsus, US world meds, UCB, Impax,Lundbeck</p></list-item></list></p><p><list list-type="order"><title>Speakers' Bureaus:</title><list-item><p>Speaker for Teva, UCB, US world meds, Impax,Lundbeck</p></list-item></list></p><p><list list-type="order"><title>Other Activities:</title><list-item><p>NONE</p></list-item></list></p><p><list list-type="order"><title>Clinical Procedures or Imaging Studies:</title><list-item><p>NONE</p></list-item></list></p><p><list list-type="order"><title>Research Support, Commercial Entities:</title><list-item><p>Research support from Pfizer, US world meds, PSG, HSG, Teva, Abbvie, Merck, Astellas,</p></list-item></list></p><p><list list-type="order"><title>Research Support, Government Entities:</title><list-item><p>NIH grants through PSG, HSG and Dystonia medical research foundation,</p></list-item></list></p><p><list list-type="order"><title>Research Support, Academic Entities:</title><list-item><p>NONE</p></list-item></list></p><p><list list-type="order"><title>Research Support, Foundations and Societies:</title><list-item><p>Parkinson's support group, dystonia support group and Huntington's support group</p></list-item></list></p><p><list list-type="order"><title>Stock/Stock Options/Board of Directors Compensation:</title><list-item><p>Spouse has Stock in Exilexis, Pharmaathens, Atossa Genetics, Pain Therapeutics, Antares, MEI Pharma, Marina Biotech, RXi Pharmaceuticals,</p></list-item></list></p><p><list list-type="order"><title>License Fee Payments, Technology or Inventions:</title><list-item><p>NONE</p></list-item></list></p><p><list list-type="order"><title>Royalty Payments, Technology or Inventions:</title><list-item><p>NONE</p></list-item></list></p><p><list list-type="order"><title>Stock/Stock Options, Research Sponsor:</title><list-item><p>NONE</p></list-item></list></p><p><list list-type="order"><title>Stock/Stock Options, Medical Equipment & Materials:</title><list-item><p>Spouse has Stock in Exilexis, Pharmaathens, Atossa Genetics, Pain Therapeutics, Antares, MEI Pharma, Marina Biotech, RXi Pharmaceuticals,</p></list-item></list></p><p><list list-type="order"><title>Legal Proceedings:</title><list-item><p>NONE</p></list-item></list></p></author-comment></contrib><contrib contrib-type="author"><name><surname>Stover</surname><given-names>Natividad P.</given-names></name><degrees>MD</degrees><author-comment content-type="disclosure"><p><list list-type="order"><title>Scientific Advisory Boards:</title><list-item><p>NONE</p></list-item></list></p><p><list list-type="order"><title>Gifts:</title><list-item><p>NONE</p></list-item></list></p><p><list list-type="order"><title>Funding for Travel or Speaker Honoraria:</title><list-item><p>NONE</p></list-item></list></p><p><list list-type="order"><title>Editorial Boards:</title><list-item><p>NONE</p></list-item></list></p><p><list list-type="order"><title>Patents:</title><list-item><p>NONE</p></list-item></list></p><p><list list-type="order"><title>Publishing Royalties:</title><list-item><p>NONE</p></list-item></list></p><p><list list-type="order"><title>Employment, Commercial Entity:</title><list-item><p>NONE</p></list-item></list></p><p><list list-type="order"><title>Consultancies:</title><list-item><p>NONE</p></list-item></list></p><p><list list-type="order"><title>Speakers' Bureaus:</title><list-item><p>NONE</p></list-item></list></p><p><list list-type="order"><title>Other Activities:</title><list-item><p>NONE</p></list-item></list></p><p><list list-type="order"><title>Clinical Procedures or Imaging Studies:</title><list-item><p>NONE</p></list-item></list></p><p><list list-type="order"><title>Research Support, Commercial Entities:</title><list-item><p>NONE</p></list-item></list></p><p><list list-type="order"><title>Research Support, Government Entities:</title><list-item><p>NONE</p></list-item></list></p><p><list list-type="order"><title>Research Support, Academic Entities:</title><list-item><p>NONE</p></list-item></list></p><p><list list-type="order"><title>Research Support, Foundations and Societies:</title><list-item><p>NONE</p></list-item></list></p><p><list list-type="order"><title>Stock/Stock Options/Board of Directors Compensation:</title><list-item><p>NONE</p></list-item></list></p><p><list list-type="order"><title>License Fee Payments, Technology or Inventions:</title><list-item><p>NONE</p></list-item></list></p><p><list list-type="order"><title>Royalty Payments, Technology or Inventions:</title><list-item><p>NONE</p></list-item></list></p><p><list list-type="order"><title>Stock/Stock Options, Research Sponsor:</title><list-item><p>NONE</p></list-item></list></p><p><list list-type="order"><title>Stock/Stock Options, Medical Equipment & Materials:</title><list-item><p>NONE</p></list-item></list></p><p><list list-type="order"><title>Legal Proceedings:</title><list-item><p>NONE</p></list-item></list></p></author-comment><on-behalf-of>On behalf of the Dystonia Coalition Investigators, Dystonia Genetic Consortium</on-behalf-of></contrib><aff>From the Departments of Neurology and Anatomy & Neurobiology (M.S.L., S.R.V., J.X., M.M.T.), University of Tennessee Health Science Center, Memphis, TN; Department of Neurology (J.S.P., L.J.W.), Washington University School of Medicine, St. Louis, MO; Departments of Neurology (A.R.R.), Human Genetics, and Pediatrics (H.A.J.), School of Medicine, Emory University, Atlanta, GA; Department of Neurology (P.H.), Vanderbilt University, Nashville, TN; Department of Neurological Sciences (C.L.C.), Rush University, Chicago, IL; Institute of Neurogenetics (A.W., J. Junker), University of Lübeck, Germany; Department of Neurology (J. Jankovic), Baylor College of Medicine, Houston, TX; Department of Neurology (R.L.B.), University of Rochester, NY; Department of Neurology (S.G.R.), University of Maryland, Baltimore, MD; Department of Neurology (R.L.R.), University of Florida, Gainesville, FL; Department of Neurology (B.D.B.), University of Colorado Denver School of Medicine, Aurora, CO; Center of Excellence in Neuroscience (S.C.), University of Montreal, QC, Canada; Mirken Department of Neurology (L.S.), Mt. Sinai Beth Israel Medical Center, New York, NY; Booth Gardner Parkinson's Care Center (P.A.), Kirkland, WA; and Department of Neurology (N.P.S.), University of Alabama at Birmingham, AL.</aff></contrib-group><contrib-group><contrib contrib-type="collab"><collab>Dystonia Coalition Investigators, Dystonia Genetic Consortium</collab></contrib><contrib contrib-type="collab"><name><surname>Marsh</surname><given-names>Laura</given-names></name><degrees>MD</degrees></contrib><contrib contrib-type="collab"><name><surname>Shih</surname><given-names>Ludy</given-names></name><degrees>MD</degrees></contrib><contrib contrib-type="collab"><name><surname>Bressman</surname><given-names>Susan</given-names></name><degrees>MD</degrees></contrib><contrib contrib-type="collab"><name><surname>Factor</surname><given-names>Stewart</given-names></name><degrees>DO</degrees></contrib><contrib contrib-type="collab"><name><surname>Vidailhet</surname><given-names>Marie</given-names></name><degrees>MD</degrees></contrib><contrib contrib-type="collab"><name><surname>Roze</surname><given-names>Emmanuel</given-names></name><degrees>MD, PhD</degrees></contrib><contrib contrib-type="collab"><name><surname>Mari</surname><given-names>Zoltan</given-names></name><degrees>MD</degrees></contrib><contrib contrib-type="collab"><name><surname>Adler</surname><given-names>Charles</given-names></name><degrees>MD, PhD</degrees></contrib><contrib contrib-type="collab"><name><surname>Hallett</surname><given-names>Mark</given-names></name><degrees>MD</degrees></contrib><contrib contrib-type="collab"><name><surname>Ramos</surname><given-names>Vesper F.M. L.</given-names></name><degrees>MD</degrees></contrib><contrib contrib-type="collab"><name><surname>Grill</surname><given-names>Stephen</given-names></name><degrees>MD, PhD</degrees></contrib><contrib contrib-type="collab"><name><surname>Goetz</surname><given-names>Christopher</given-names></name><degrees>MD</degrees></contrib><contrib contrib-type="collab"><name><surname>Harlow</surname><given-names>Tanya</given-names></name><degrees>MD</degrees></contrib><contrib contrib-type="collab"><name><surname>Fox</surname><given-names>Susan</given-names></name><degrees>MB, ChB, PhD</degrees></contrib><contrib contrib-type="collab"><name><surname>Standaert</surname><given-names>David</given-names></name><degrees>MD, PhD</degrees></contrib><contrib contrib-type="collab"><name><surname>Suchowersky</surname><given-names>Oksana</given-names></name><degrees>MD</degrees></contrib><contrib contrib-type="collab"><name><surname>Nahab</surname><given-names>Fatta</given-names></name><degrees>MD</degrees></contrib><contrib contrib-type="collab"><name><surname>Xie</surname><given-names>Tao</given-names></name><degrees>MD, PhD</degrees></contrib><contrib contrib-type="collab"><name><surname>Espay</surname><given-names>Alberto</given-names></name><degrees>MD</degrees></contrib><contrib contrib-type="collab"><name><surname>Okun</surname><given-names>Michael</given-names></name><degrees>MD</degrees></contrib><contrib contrib-type="collab"><name><surname>Gonzalez-Alegre</surname><given-names>Pedro</given-names></name><degrees>MD, PhD</degrees></contrib><contrib contrib-type="collab"><name><surname>Uc</surname><given-names>Ergun</given-names></name><degrees>MD</degrees></contrib><contrib contrib-type="collab"><name><surname>Klein</surname><given-names>Christine</given-names></name><degrees>MD</degrees></contrib><contrib contrib-type="collab"><name><surname>Pirio Richardson</surname><given-names>Sarah</given-names></name><degrees>MD</degrees></contrib><contrib contrib-type="collab"><name><surname>Berardelli</surname><given-names>Alfredo</given-names></name><degrees>MD</degrees></contrib><contrib contrib-type="collab"><name><surname>Fabbrini</surname><given-names>Giovanni</given-names></name><degrees>MD</degrees></contrib><contrib contrib-type="collab"><name><surname>Ondo</surname><given-names>William</given-names></name><degrees>MD</degrees></contrib><contrib contrib-type="collab"><name><surname>Testa</surname><given-names>Claudia</given-names></name><degrees>MD, PhD</degrees></contrib><contrib contrib-type="collab"><name><surname>Brashear</surname><given-names>Alison</given-names></name><degrees>MD</degrees></contrib><contrib contrib-type="collab"><name><surname>Pfeiffer</surname><given-names>Ronald F.</given-names></name><degrees>MD</degrees></contrib><contrib contrib-type="collab"><name><surname>Rudzińska</surname><given-names>Monika</given-names></name><degrees>MD, PhD</degrees></contrib><contrib contrib-type="collab"><name><surname>Wszolek</surname><given-names>Zbigniew K.</given-names></name><degrees>MD</degrees></contrib><contrib contrib-type="collab"><name><surname>Uitti</surname><given-names>Ryan J.</given-names></name><degrees>MD</degrees></contrib><contrib contrib-type="collab"><name><surname>Van Gerpen</surname><given-names>Jay A.</given-names></name><degrees>MD</degrees></contrib><contrib contrib-type="collab"><name><surname>Bastian</surname><given-names>Robert W.</given-names></name><degrees>MD</degrees></contrib></contrib-group><author-notes><corresp>Correspondence to Dr. LeDoux: <email>mledoux@uthsc.edu</email></corresp><fn fn-type="other"><p>Coinvestigators are listed at <ext-link ext-link-type="doi" xlink:href="10.1212/NXG.0000000000000069">Neurology.org/ng</ext-link>.</p></fn><fn fn-type="financial-disclosure"><p>Funding information and disclosures are provided at the end of the article. Go to <ext-link ext-link-type="doi" xlink:href="10.1212/NXG.0000000000000069">Neurology.org/ng</ext-link> for full disclosure forms. The Article Processing Charge was paid by the authors.</p></fn></author-notes><pub-date pub-type="epub"><day>11</day><month>4</month><year>2016</year></pub-date><pub-date pub-type="collection"><month>6</month><year>2016</year></pub-date><pub-date pub-type="pmc-release"><day>11</day><month>4</month><year>2016</year></pub-date><pmc-comment> PMC Release delay is 0 months and 0 days and was based on the
<volume>2</volume><issue>3</issue><elocation-id>e69</elocation-id><history><date date-type="received"><day>05</day><month>2</month><year>2016</year></date><date date-type="accepted"><day>01</day><month>3</month><year>2016</year></date></history><permissions><copyright-statement>© 2016 American Academy of Neurology</copyright-statement><copyright-year>2016</copyright-year><copyright-holder>American Academy of Neurology</copyright-holder><license license-type="open-access"><license-p>This is an open access article distributed under the terms of the <ext-link ext-link-type="uri" xlink:href="http://creativecommons.org/licenses/by-nc-nd/4.0/">Creative Commons Attribution-NonCommercial-NoDerivatives License 4.0 (CC BY-NC-ND)</ext-link>, which permits downloading and sharing the work provided it is properly cited. The work cannot be changed in any way or used commercially.</license-p></license></permissions><self-uri xlink:title="pdf" xlink:type="simple" xlink:href="NG2016002071.pdf"></self-uri><abstract><sec><title>Objective:</title><p>To characterize the clinical and genetic features of cervical dystonia (CD).</p></sec><sec><title>Methods:</title><p>Participants enrolled in the Dystonia Coalition biorepository (NCT01373424) with initial manifestation as CD were included in this study (n = 1,000). Data intake included demographics, family history, and the Global Dystonia Rating Scale. Participants were screened for sequence variants (SVs) in <italic>GNAL</italic>, <italic>THAP1</italic>, and Exon 5 of <italic>TOR1A</italic>.</p></sec><sec><title>Results:</title><p>The majority of participants were Caucasian (95%) and female (75%). The mean age at onset and disease duration were 45.5 ± 13.6 and 14.6 ± 11.8 years, respectively. At the time of assessment, 68.5% had involvement limited to the neck, shoulder(s), and proximal arm(s), whereas 47.4% had dystonia limited to the neck. The remaining 31.5% of the individuals exhibited more extensive anatomical spread. A head tremor was noted in 62% of the patients. Head tremor and laryngeal dystonia were more common in females. Psychiatric comorbidities, mainly depression and anxiety, were reported by 32% of the participants and were more common in females. Family histories of dystonia, parkinsonian disorder, and tremor were present in 14%, 11%, and 29% of the patients, respectively. Pathogenic or likely pathogenic SVs in <italic>THAP1</italic>, <italic>TOR1A</italic>, and <italic>GNAL</italic> were identified in 8 participants (0.8%). Two individuals harbored novel missense SVs in Exon 5 of <italic>TOR1A</italic>. Synonymous and noncoding SVs in <italic>THAP1</italic> and <italic>GNAL</italic> were identified in 4% of the cohort.</p></sec><sec><title>Conclusions:</title><p>Head tremor, laryngeal dystonia, and psychiatric comorbidities are more common in female participants with CD. Coding and noncoding variants in <italic>GNAL</italic>, <italic>THAP1</italic>, and <italic>TOR1A</italic> make small contributions to the pathogenesis of CD.</p></sec></abstract><custom-meta-group><custom-meta><meta-name>OPEN-ACCESS</meta-name><meta-value>TRUE</meta-value></custom-meta></custom-meta-group></article-meta></front></pmc><affiliations><list><country><li>États-Unis</li></country><region><li>Texas</li></region><settlement><li>Houston</li></settlement><orgName><li>Baylor College of Medicine</li></orgName></list><tree><noCountry><name sortKey="Agarwal, Pinky" sort="Agarwal, Pinky" uniqKey="Agarwal P" first="Pinky" last="Agarwal">Pinky Agarwal</name><name sortKey="Barbano, Richard L" sort="Barbano, Richard L" uniqKey="Barbano R" first="Richard L." last="Barbano">Richard L. Barbano</name><name sortKey="Berman, Brian D" sort="Berman, Brian D" uniqKey="Berman B" first="Brian D." last="Berman">Brian D. Berman</name><name sortKey="Chouinard, Sylvain" sort="Chouinard, Sylvain" uniqKey="Chouinard S" first="Sylvain" last="Chouinard">Sylvain Chouinard</name><name sortKey="Comella, Cynthia L" sort="Comella, Cynthia L" uniqKey="Comella C" first="Cynthia L." last="Comella">Cynthia L. Comella</name><name sortKey="Hedera, Peter" sort="Hedera, Peter" uniqKey="Hedera P" first="Peter" last="Hedera">Peter Hedera</name><name sortKey="Jinnah, H A" sort="Jinnah, H A" uniqKey="Jinnah H" first="H. A." last="Jinnah">H. A. Jinnah</name><name sortKey="Junker, Johanna" sort="Junker, Johanna" uniqKey="Junker J" first="Johanna" last="Junker">Johanna Junker</name><name sortKey="Ledoux, Mark S" sort="Ledoux, Mark S" uniqKey="Ledoux M" first="Mark S." last="Ledoux">Mark S. Ledoux</name><name sortKey="Perlmutter, Joel S" sort="Perlmutter, Joel S" uniqKey="Perlmutter J" first="Joel S." last="Perlmutter">Joel S. Perlmutter</name><name sortKey="Reich, Stephen G" sort="Reich, Stephen G" uniqKey="Reich S" first="Stephen G." last="Reich">Stephen G. Reich</name><name sortKey="Rodriguez, Ramon L" sort="Rodriguez, Ramon L" uniqKey="Rodriguez R" first="Ramon L." last="Rodriguez">Ramon L. Rodriguez</name><name sortKey="Rosen, Ami R" sort="Rosen, Ami R" uniqKey="Rosen A" first="Ami R." last="Rosen">Ami R. Rosen</name><name sortKey="Severt, Lawrence" sort="Severt, Lawrence" uniqKey="Severt L" first="Lawrence" last="Severt">Lawrence Severt</name><name sortKey="Stover, Natividad P" sort="Stover, Natividad P" uniqKey="Stover N" first="Natividad P." last="Stover">Natividad P. Stover</name><name sortKey="Thompson, Misty M" sort="Thompson, Misty M" uniqKey="Thompson M" first="Misty M." last="Thompson">Misty M. Thompson</name><name sortKey="Vemula, Satya R" sort="Vemula, Satya R" uniqKey="Vemula S" first="Satya R." last="Vemula">Satya R. Vemula</name><name sortKey="Weissbach, Anne" sort="Weissbach, Anne" uniqKey="Weissbach A" first="Anne" last="Weissbach">Anne Weissbach</name><name sortKey="Wright, Laura J" sort="Wright, Laura J" uniqKey="Wright L" first="Laura J." last="Wright">Laura J. Wright</name><name sortKey="Xiao, Jianfeng" sort="Xiao, Jianfeng" uniqKey="Xiao J" first="Jianfeng" last="Xiao">Jianfeng Xiao</name></noCountry><country name="États-Unis"><region name="Texas"><name sortKey="Jankovic, Joseph" sort="Jankovic, Joseph" uniqKey="Jankovic J" first="Joseph" last="Jankovic">Joseph Jankovic</name></region></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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