La maladie de Parkinson au Canada (serveur d'exploration)

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Chronic D1 and D2 dopaminomimetic treatment of MPTP-denervated monkeys : effects on basal ganglia GABAA/ benzodiazepine receptor complex and GABA content

Identifieur interne : 001165 ( PascalFrancis/Curation ); précédent : 001164; suivant : 001166

Chronic D1 and D2 dopaminomimetic treatment of MPTP-denervated monkeys : effects on basal ganglia GABAA/ benzodiazepine receptor complex and GABA content

Auteurs : F. Calon [Canada] ; M. Morissette [Canada] ; M. Goulet [Canada] ; R. Grondin [Canada] ; P. J. Blanchet [Canada] ; P. J. Bedard [Canada] ; T. Di Paolo [Canada]

Source :

RBID : Pascal:99-0333352

Descripteurs français

English descriptors

Abstract

The effect of various chronic dopaminergic treatments in 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP) monkeys on the brain γ-aminobutyric acid type A (GABAA) /benzodiazepine receptor complex and GABA content was investigated in order to assess the GABAergic involvement in dopaminomimetic-induced dyskinesia. Three MPTP monkeys received for one month pulsatile administrations of the Dl dopamine (DA) receptor agonist SKF 82958 whereas three others received the same dose of SKF 82958 by continuous infusion. A long acting D2 DA receptor agonist, cabergoline, was given to another three animals. Untreated MPTP as well as naive control animals were also included. Pulsatile SKF 82958 relieved parkinsonian symptoms but was also associated with dyskinesia in two of the three animals whereas animals treated continuously with SKF 82958 remained as untreated MPTP monkeys. Chronic cabergoline administration improved motor response with no persistent dyskinesia. MPTP treatment induced a decrease of 3H-flunitrazepam binding in the medial anterior part of caudate-putamen and an increase in the internal segment of globus pallidus (GPi) which was in general unchanged by pulsatile or continuous SKF 82958 administration. Throughout the striatum, binding of 3H-flunitrazepam remained reduced in MPTP monkeys treated with cabergoline but was not significantly lower than untreated MPTP monkeys. Moreover, cabergoline treatment reversed the MPTP-induced increase in 3H-flunitrazepam binding in the GPi. GABA concentrations remained unchanged in the striatum, external segment of globus pallidus and GPi following MPTP denervation. Pulsatile but not continuous SKF 82958 administration decreased putamen GABA content whereas cabergoline treatment decreased caudate GABA. No alteration in GABA levels were observed in the GPe and GPi following the experimental treatments. These results suggest that: (1) D2-like receptor stimulation with cabergoline modulates GABAA receptor density in striatal subregions anatomically related to associative cortical afferent and (2) the absence of dyskinesia in dopaminomimetic-treated monkeys might be associated with the reversal of the MPTP-induced upregulation of the GABAA/benzodiazepine receptor complex in the Gpi.
pA  
A01 01  1    @0 0197-0186
A02 01      @0 NEUIDS
A03   1    @0 Neurochem. int.
A05       @2 35
A06       @2 1
A08 01  1  ENG  @1 Chronic D1 and D2 dopaminomimetic treatment of MPTP-denervated monkeys : effects on basal ganglia GABAA/ benzodiazepine receptor complex and GABA content
A11 01  1    @1 CALON (F.)
A11 02  1    @1 MORISSETTE (M.)
A11 03  1    @1 GOULET (M.)
A11 04  1    @1 GRONDIN (R.)
A11 05  1    @1 BLANCHET (P. J.)
A11 06  1    @1 BEDARD (P. J.)
A11 07  1    @1 DI PAOLO (T.)
A14 01      @1 Centre de Recherches en Endocrinologie Moléculaire, Le Centre Hospitalier Universitaire de Quebec, Pavillon CHUL @2 Québec, G1V 4G2 @3 CAN @Z 1 aut. @Z 2 aut. @Z 3 aut. @Z 4 aut. @Z 7 aut.
A14 02      @1 Faculty of Pharmacy, Laval University @2 Québec, G1K 7P4 @3 CAN @Z 1 aut. @Z 2 aut. @Z 3 aut. @Z 4 aut. @Z 7 aut.
A14 03      @1 Unité de Recherche en Neuroscience, Le Centre Hospitalier Universitaire de Quebec, Pavillon CHUL @2 Quebec, G1V 4G2 @3 CAN @Z 4 aut. @Z 5 aut. @Z 6 aut.
A14 04      @1 Department of Medicine, Faculty of Medicine, Laval University @2 Québec, G1K 7P4 @3 CAN @Z 4 aut. @Z 5 aut. @Z 6 aut.
A20       @1 81-91
A21       @1 1999
A23 01      @0 ENG
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A60       @1 P
A61       @0 A
A64 01  1    @0 Neurochemistry international
A66 01      @0 USA
C01 01    ENG  @0 The effect of various chronic dopaminergic treatments in 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP) monkeys on the brain γ-aminobutyric acid type A (GABAA) /benzodiazepine receptor complex and GABA content was investigated in order to assess the GABAergic involvement in dopaminomimetic-induced dyskinesia. Three MPTP monkeys received for one month pulsatile administrations of the Dl dopamine (DA) receptor agonist SKF 82958 whereas three others received the same dose of SKF 82958 by continuous infusion. A long acting D2 DA receptor agonist, cabergoline, was given to another three animals. Untreated MPTP as well as naive control animals were also included. Pulsatile SKF 82958 relieved parkinsonian symptoms but was also associated with dyskinesia in two of the three animals whereas animals treated continuously with SKF 82958 remained as untreated MPTP monkeys. Chronic cabergoline administration improved motor response with no persistent dyskinesia. MPTP treatment induced a decrease of 3H-flunitrazepam binding in the medial anterior part of caudate-putamen and an increase in the internal segment of globus pallidus (GPi) which was in general unchanged by pulsatile or continuous SKF 82958 administration. Throughout the striatum, binding of 3H-flunitrazepam remained reduced in MPTP monkeys treated with cabergoline but was not significantly lower than untreated MPTP monkeys. Moreover, cabergoline treatment reversed the MPTP-induced increase in 3H-flunitrazepam binding in the GPi. GABA concentrations remained unchanged in the striatum, external segment of globus pallidus and GPi following MPTP denervation. Pulsatile but not continuous SKF 82958 administration decreased putamen GABA content whereas cabergoline treatment decreased caudate GABA. No alteration in GABA levels were observed in the GPe and GPi following the experimental treatments. These results suggest that: (1) D2-like receptor stimulation with cabergoline modulates GABAA receptor density in striatal subregions anatomically related to associative cortical afferent and (2) the absence of dyskinesia in dopaminomimetic-treated monkeys might be associated with the reversal of the MPTP-induced upregulation of the GABAA/benzodiazepine receptor complex in the Gpi.
C02 01  X    @0 002B17G
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C03 02  X  SPA  @0 Neurotoxina @5 02
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C03 03  X  SPA  @0 Núcleo basal @5 03
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C03 04  X  SPA  @0 Receptor benzodiazepínico @5 04
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C03 05  X  SPA  @0 Receptor gabaminérgico A @5 05
C03 06  X  FRE  @0 GABA @2 NK @5 06
C03 06  X  ENG  @0 GABA @2 NK @5 06
C03 06  X  SPA  @0 GABA @2 NK @5 06
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C03 11  X  FRE  @0 Récepteur dopaminergique D2 @5 11
C03 11  X  ENG  @0 D2 Dopamine receptor @5 11 @6 «D2» Dopamine receptor
C03 11  X  SPA  @0 Receptor dopaminérgico D2 @5 11
C03 12  X  FRE  @0 Pathologie expérimentale @5 13
C03 12  X  ENG  @0 Experimental disease @5 13
C03 12  X  SPA  @0 Patología experimental @5 13
C03 13  X  FRE  @0 Animal @5 14
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C03 14  X  FRE  @0 Singe @5 54
C03 14  X  ENG  @0 Monkey @5 54
C03 14  X  SPA  @0 Mono @5 54
C03 15  X  FRE  @0 MPTP @4 INC @5 81
C07 01  X  FRE  @0 Encéphale @5 26
C07 01  X  ENG  @0 Brain (vertebrata) @5 26
C07 01  X  SPA  @0 Encéfalo @5 26
C07 02  X  FRE  @0 Système nerveux central @5 27
C07 02  X  ENG  @0 Central nervous system @5 27
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C07 07  X  FRE  @0 Maladie dégénérative @5 42
C07 07  X  ENG  @0 Degenerative disease @5 42
C07 07  X  SPA  @0 Enfermedad degenerativa @5 42
C07 08  X  FRE  @0 Primates @2 NS
C07 08  X  ENG  @0 Primates @2 NS
C07 08  X  SPA  @0 Primates @2 NS
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N21       @1 207

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Pascal:99-0333352

Le document en format XML

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<title level="j" type="main">Neurochemistry international</title>
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<term>Chronic</term>
<term>D1 Dopamine receptor</term>
<term>D2 Dopamine receptor</term>
<term>Dyskinesia</term>
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<div type="abstract" xml:lang="en">The effect of various chronic dopaminergic treatments in 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP) monkeys on the brain γ-aminobutyric acid type A (GABA
<sub>A</sub>
) /benzodiazepine receptor complex and GABA content was investigated in order to assess the GABAergic involvement in dopaminomimetic-induced dyskinesia. Three MPTP monkeys received for one month pulsatile administrations of the Dl dopamine (DA) receptor agonist SKF 82958 whereas three others received the same dose of SKF 82958 by continuous infusion. A long acting D2 DA receptor agonist, cabergoline, was given to another three animals. Untreated MPTP as well as naive control animals were also included. Pulsatile SKF 82958 relieved parkinsonian symptoms but was also associated with dyskinesia in two of the three animals whereas animals treated continuously with SKF 82958 remained as untreated MPTP monkeys. Chronic cabergoline administration improved motor response with no persistent dyskinesia. MPTP treatment induced a decrease of
<sup>3</sup>
H-flunitrazepam binding in the medial anterior part of caudate-putamen and an increase in the internal segment of globus pallidus (GPi) which was in general unchanged by pulsatile or continuous SKF 82958 administration. Throughout the striatum, binding of
<sup>3</sup>
H-flunitrazepam remained reduced in MPTP monkeys treated with cabergoline but was not significantly lower than untreated MPTP monkeys. Moreover, cabergoline treatment reversed the MPTP-induced increase in
<sup>3</sup>
H-flunitrazepam binding in the GPi. GABA concentrations remained unchanged in the striatum, external segment of globus pallidus and GPi following MPTP denervation. Pulsatile but not continuous SKF 82958 administration decreased putamen GABA content whereas cabergoline treatment decreased caudate GABA. No alteration in GABA levels were observed in the GPe and GPi following the experimental treatments. These results suggest that: (1) D2-like receptor stimulation with cabergoline modulates GABA
<sub>A</sub>
receptor density in striatal subregions anatomically related to associative cortical afferent and (2) the absence of dyskinesia in dopaminomimetic-treated monkeys might be associated with the reversal of the MPTP-induced upregulation of the GABA
<sub>A</sub>
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<sup>3</sup>
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<s5>38</s5>
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<fC07 i1="04" i2="X" l="FRE">
<s0>Système nerveux central pathologie</s0>
<s5>39</s5>
</fC07>
<fC07 i1="04" i2="X" l="ENG">
<s0>Central nervous system disease</s0>
<s5>39</s5>
</fC07>
<fC07 i1="04" i2="X" l="SPA">
<s0>Sistema nervosio central patología</s0>
<s5>39</s5>
</fC07>
<fC07 i1="05" i2="X" l="FRE">
<s0>Encéphale pathologie</s0>
<s5>40</s5>
</fC07>
<fC07 i1="05" i2="X" l="ENG">
<s0>Cerebral disorder</s0>
<s5>40</s5>
</fC07>
<fC07 i1="05" i2="X" l="SPA">
<s0>Encéfalo patología</s0>
<s5>40</s5>
</fC07>
<fC07 i1="06" i2="X" l="FRE">
<s0>Extrapyramidal syndrome</s0>
<s5>41</s5>
</fC07>
<fC07 i1="06" i2="X" l="ENG">
<s0>Extrapyramidal syndrome</s0>
<s5>41</s5>
</fC07>
<fC07 i1="06" i2="X" l="SPA">
<s0>Extrapiramidal síndrome</s0>
<s5>41</s5>
</fC07>
<fC07 i1="07" i2="X" l="FRE">
<s0>Maladie dégénérative</s0>
<s5>42</s5>
</fC07>
<fC07 i1="07" i2="X" l="ENG">
<s0>Degenerative disease</s0>
<s5>42</s5>
</fC07>
<fC07 i1="07" i2="X" l="SPA">
<s0>Enfermedad degenerativa</s0>
<s5>42</s5>
</fC07>
<fC07 i1="08" i2="X" l="FRE">
<s0>Primates</s0>
<s2>NS</s2>
</fC07>
<fC07 i1="08" i2="X" l="ENG">
<s0>Primates</s0>
<s2>NS</s2>
</fC07>
<fC07 i1="08" i2="X" l="SPA">
<s0>Primates</s0>
<s2>NS</s2>
</fC07>
<fC07 i1="09" i2="X" l="FRE">
<s0>Mammalia</s0>
<s2>NS</s2>
</fC07>
<fC07 i1="09" i2="X" l="ENG">
<s0>Mammalia</s0>
<s2>NS</s2>
</fC07>
<fC07 i1="09" i2="X" l="SPA">
<s0>Mammalia</s0>
<s2>NS</s2>
</fC07>
<fC07 i1="10" i2="X" l="FRE">
<s0>Vertebrata</s0>
<s2>NS</s2>
</fC07>
<fC07 i1="10" i2="X" l="ENG">
<s0>Vertebrata</s0>
<s2>NS</s2>
</fC07>
<fC07 i1="10" i2="X" l="SPA">
<s0>Vertebrata</s0>
<s2>NS</s2>
</fC07>
<fN21>
<s1>207</s1>
</fN21>
</pA>
</standard>
</inist>
</record>

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