Family history of idiopathic REM behavior disorder: A multicenter case-control study
Identifieur interne : 000B43 ( PascalFrancis/Curation ); précédent : 000B42; suivant : 000B44Family history of idiopathic REM behavior disorder: A multicenter case-control study
Auteurs : Yves Dauvilliers [France] ; Ronald B. Postuma [France, Canada] ; Luigi Ferini-Strambi [Italie] ; Isabelle Arnulf [France] ; Birgit Högl [Autriche] ; Raffaele Manni [Italie] ; Tomoyuki Miyamoto [Japon] ; Wolfgang Oertel [Allemagne] ; Maria Livia Fantini [Italie] ; Monica Puligheddu [Italie] ; Poul Jennum [Danemark] ; Karel Sonka [République tchèque] ; Marco Zucconi [Italie] ; Smeranda Leu-Semenescu [France] ; Birgit Frauscher [Autriche] ; Michele Terzaghi [Italie] ; Masayuki Miyamoto [Japon] ; Marcus Unger [Allemagne] ; Alex Desautels [France] ; Christina Wolfson [Canada] ; Amélie Pelletier [Canada] ; Jacques Montplaisir [France]Source :
- Neurology [ 0028-3878 ] ; 2013.
Descripteurs français
- Pascal (Inist)
English descriptors
Abstract
Objective: To compare the frequency of proxy-reported REM sleep behavior disorder (RBD) among relatives of patients with polysomnogram-diagnosed idiopathic RBD (iRBD) in comparison to controls using a large multicenter clinic-based cohort. Methods: A total of 316 patients with polysomnography-confirmed iRBD were recruited from 12 RBD study group centers, along with 316 controls matched on sex and age group. All subjects completed a self-administered questionnaire that collected proxy-reported information on family history of tremor, gait trouble, balance trouble, Parkinson disease, memory loss, and Alzheimer disease. The questionnaire also included a single question that asked about possible symptoms of RBD among first-degree relatives (siblings, parents, and children). Results: A positive family history of dream enactment was reported in 13.8% of iRBD cases compared to 4.8% of controls (odds ratio [OR] = 3.9, 95% confidence interval [CI] 2.0-7.7). ORs were increased for both siblings (OR = 6.1, 95% CI 2.1-18.1) and parents (OR = 3.2, 95% CI 1.4-7.8). We found no significant difference in sex, current age (65.3 ± 10.2 vs 66.9 ± 10.2 years), or age at self-reported RBD onset (55.2 ± 11.7 vs 56.6 ± 15.1 years) in possible familial vs sporadic iRBD. No differences were found in family history of tremor, walking and balance troubles, Parkinson disease, memory loss, or Alzheimer disease. Conclusion: We found increased odds of proxy-reported family history of presumed RBD among individuals with confirmed iRBD. This suggests the possibility of a genetic contribution to RBD.
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Mondino, Foundation</s1><s2>Pavia</s2><s3>ITA</s3><sZ>6 aut.</sZ><sZ>16 aut.</sZ></inist:fA14><country>Italie</country></affiliation></author><author><name sortKey="Miyamoto, Masayuki" sort="Miyamoto, Masayuki" uniqKey="Miyamoto M" first="Masayuki" last="Miyamoto">Masayuki Miyamoto</name><affiliation wicri:level="1"><inist:fA14 i1="08"><s1>Department of Neurology, Dokkyo Medical University Koshigaya Hospital</s1><s2>Saitama</s2><s3>JPN</s3><sZ>7 aut.</sZ><sZ>17 aut.</sZ></inist:fA14><country>Japon</country></affiliation></author><author><name sortKey="Unger, Marcus" sort="Unger, Marcus" uniqKey="Unger M" first="Marcus" last="Unger">Marcus Unger</name><affiliation wicri:level="1"><inist:fA14 i1="09"><s1>Department of Neurology, Philipps-Universität</s1><s2>Marburg</s2><s3>DEU</s3><sZ>8 aut.</sZ><sZ>18 aut.</sZ></inist:fA14><country>Allemagne</country></affiliation><affiliation wicri:level="1"><inist:fA14 i1="14"><s1>Department of Neurology, Saarland University</s1><s2>Homburg/Saar</s2><s3>DEU</s3><sZ>18 aut.</sZ></inist:fA14><country>Allemagne</country></affiliation></author><author><name sortKey="Desautels, Alex" sort="Desautels, Alex" uniqKey="Desautels A" first="Alex" last="Desautels">Alex Desautels</name><affiliation wicri:level="1"><inist:fA14 i1="02"><s1>Centre d'Études Avancées en Médecine du Sommeil, Hôpiral du Sacré-Cœur de Montréal</s1><s2>Montréal</s2><s3>FRA</s3><sZ>2 aut.</sZ><sZ>19 aut.</sZ><sZ>22 aut.</sZ></inist:fA14><country>France</country></affiliation></author><author><name sortKey="Wolfson, Christina" sort="Wolfson, Christina" uniqKey="Wolfson C" first="Christina" last="Wolfson">Christina Wolfson</name><affiliation wicri:level="1"><inist:fA14 i1="15"><s1>Research Institute of the McGill University Health Center</s1><s2>Montreal</s2><s3>CAN</s3><sZ>20 aut.</sZ><sZ>21 aut.</sZ></inist:fA14><country>Canada</country></affiliation></author><author><name sortKey="Pelletier, Amelie" sort="Pelletier, Amelie" uniqKey="Pelletier A" first="Amélie" last="Pelletier">Amélie Pelletier</name><affiliation wicri:level="1"><inist:fA14 i1="15"><s1>Research Institute of the McGill University Health Center</s1><s2>Montreal</s2><s3>CAN</s3><sZ>20 aut.</sZ><sZ>21 aut.</sZ></inist:fA14><country>Canada</country></affiliation></author><author><name sortKey="Montplaisir, Jacques" sort="Montplaisir, Jacques" uniqKey="Montplaisir J" first="Jacques" last="Montplaisir">Jacques Montplaisir</name><affiliation wicri:level="1"><inist:fA14 i1="02"><s1>Centre d'Études Avancées en Médecine du Sommeil, Hôpiral du Sacré-Cœur de Montréal</s1><s2>Montréal</s2><s3>FRA</s3><sZ>2 aut.</sZ><sZ>19 aut.</sZ><sZ>22 aut.</sZ></inist:fA14><country>France</country></affiliation></author></titleStmt><publicationStmt><idno type="wicri:source">INIST</idno><idno type="inist">13-0231441</idno><date when="2013">2013</date><idno type="stanalyst">PASCAL 13-0231441 INIST</idno><idno type="RBID">Pascal:13-0231441</idno><idno type="wicri:Area/PascalFrancis/Corpus">000090</idno><idno type="wicri:Area/PascalFrancis/Curation">000B43</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en" level="a">Family history of idiopathic REM behavior disorder: A multicenter case-control study</title><author><name sortKey="Dauvilliers, Yves" sort="Dauvilliers, Yves" uniqKey="Dauvilliers Y" first="Yves" last="Dauvilliers">Yves Dauvilliers</name><affiliation wicri:level="1"><inist:fA14 i1="01"><s1>Department of Neurology, Hôpital Gui de Chauliac, Montpellier, INSERM U1061</s1><s2>Montpellier</s2><s3>FRA</s3><sZ>1 aut.</sZ></inist:fA14><country>France</country></affiliation></author><author><name sortKey="Postuma, Ronald B" sort="Postuma, Ronald B" uniqKey="Postuma R" first="Ronald B." last="Postuma">Ronald B. Postuma</name><affiliation wicri:level="1"><inist:fA14 i1="02"><s1>Centre d'Études Avancées en Médecine du Sommeil, Hôpiral du Sacré-Cœur de Montréal</s1><s2>Montréal</s2><s3>FRA</s3><sZ>2 aut.</sZ><sZ>19 aut.</sZ><sZ>22 aut.</sZ></inist:fA14><country>France</country></affiliation><affiliation wicri:level="1"><inist:fA14 i1="03"><s1>Department of Neurology, McGill University, Montreal General Hospital</s1><s2>Montreal</s2><s3>CAN</s3><sZ>2 aut.</sZ></inist:fA14><country>Canada</country></affiliation></author><author><name sortKey="Ferini Strambi, Luigi" sort="Ferini Strambi, Luigi" uniqKey="Ferini Strambi L" first="Luigi" last="Ferini-Strambi">Luigi Ferini-Strambi</name><affiliation wicri:level="1"><inist:fA14 i1="04"><s1>Sleep Disorders Center, Università Vita-Salute San Raffaele</s1><s2>Milan</s2><s3>ITA</s3><sZ>3 aut.</sZ><sZ>13 aut.</sZ></inist:fA14><country>Italie</country></affiliation></author><author><name sortKey="Arnulf, Isabelle" sort="Arnulf, Isabelle" uniqKey="Arnulf I" first="Isabelle" last="Arnulf">Isabelle Arnulf</name><affiliation wicri:level="1"><inist:fA14 i1="05"><s1>Unité des Pathologies du Sommeil, Hôpiral Pitié-Salpêtrière, APHP, and Inserm U975-CRICM-Pierre and Marie Curie University</s1><s2>Paris</s2><s3>FRA</s3><sZ>4 aut.</sZ><sZ>14 aut.</sZ></inist:fA14><country>France</country></affiliation></author><author><name sortKey="Hogl, Birgit" sort="Hogl, Birgit" uniqKey="Hogl B" first="Birgit" last="Högl">Birgit Högl</name><affiliation wicri:level="1"><inist:fA14 i1="06"><s1>Department of Neurology, Innsbruck Medical University</s1><s2>Innsbruck</s2><s3>AUT</s3><sZ>5 aut.</sZ><sZ>15 aut.</sZ></inist:fA14><country>Autriche</country></affiliation></author><author><name sortKey="Manni, Raffaele" sort="Manni, Raffaele" uniqKey="Manni R" first="Raffaele" last="Manni">Raffaele Manni</name><affiliation wicri:level="1"><inist:fA14 i1="07"><s1>Unit of Sleep Medicine, National Institute of Neurology IRCCS, C. Mondino, Foundation</s1><s2>Pavia</s2><s3>ITA</s3><sZ>6 aut.</sZ><sZ>16 aut.</sZ></inist:fA14><country>Italie</country></affiliation></author><author><name sortKey="Miyamoto, Tomoyuki" sort="Miyamoto, Tomoyuki" uniqKey="Miyamoto T" first="Tomoyuki" last="Miyamoto">Tomoyuki Miyamoto</name><affiliation wicri:level="1"><inist:fA14 i1="08"><s1>Department of Neurology, Dokkyo Medical University Koshigaya Hospital</s1><s2>Saitama</s2><s3>JPN</s3><sZ>7 aut.</sZ><sZ>17 aut.</sZ></inist:fA14><country>Japon</country></affiliation></author><author><name sortKey="Oertel, Wolfgang" sort="Oertel, Wolfgang" uniqKey="Oertel W" first="Wolfgang" last="Oertel">Wolfgang Oertel</name><affiliation wicri:level="1"><inist:fA14 i1="09"><s1>Department of Neurology, Philipps-Universität</s1><s2>Marburg</s2><s3>DEU</s3><sZ>8 aut.</sZ><sZ>18 aut.</sZ></inist:fA14><country>Allemagne</country></affiliation></author><author><name sortKey="Livia Fantini, Maria" sort="Livia Fantini, Maria" uniqKey="Livia Fantini M" first="Maria" last="Livia Fantini">Maria Livia Fantini</name><affiliation wicri:level="1"><inist:fA14 i1="10"><s1>Sleep Disorders Center, Department of Neurosciences, University of Turin</s1><s2>Turin</s2><s3>ITA</s3><sZ>9 aut.</sZ></inist:fA14><country>Italie</country></affiliation></author><author><name sortKey="Puligheddu, Monica" sort="Puligheddu, Monica" uniqKey="Puligheddu M" first="Monica" last="Puligheddu">Monica Puligheddu</name><affiliation wicri:level="1"><inist:fA14 i1="11"><s1>Sleep Center, Department of Cardiovascular and Neurological Sciences, University of Cagliari</s1><s3>ITA</s3><sZ>10 aut.</sZ></inist:fA14><country>Italie</country></affiliation></author><author><name sortKey="Jennum, Poul" sort="Jennum, Poul" uniqKey="Jennum P" first="Poul" last="Jennum">Poul Jennum</name><affiliation wicri:level="1"><inist:fA14 i1="12"><s1>Danish Center for Sleep Medicine, University of Copenhagen</s1><s3>DNK</s3><sZ>11 aut.</sZ></inist:fA14><country>Danemark</country></affiliation></author><author><name sortKey="Sonka, Karel" sort="Sonka, Karel" uniqKey="Sonka K" first="Karel" last="Sonka">Karel Sonka</name><affiliation wicri:level="1"><inist:fA14 i1="13"><s1>Department of Neurology First Faculty of Medicine, Charles University and General University Hospital</s1><s2>Prague</s2><s3>CZE</s3><sZ>12 aut.</sZ></inist:fA14><country>République tchèque</country></affiliation></author><author><name sortKey="Zucconi, Marco" sort="Zucconi, Marco" uniqKey="Zucconi M" first="Marco" last="Zucconi">Marco Zucconi</name><affiliation wicri:level="1"><inist:fA14 i1="04"><s1>Sleep Disorders Center, Università Vita-Salute San Raffaele</s1><s2>Milan</s2><s3>ITA</s3><sZ>3 aut.</sZ><sZ>13 aut.</sZ></inist:fA14><country>Italie</country></affiliation></author><author><name sortKey="Leu Semenescu, Smeranda" sort="Leu Semenescu, Smeranda" uniqKey="Leu Semenescu S" first="Smeranda" last="Leu-Semenescu">Smeranda Leu-Semenescu</name><affiliation wicri:level="1"><inist:fA14 i1="05"><s1>Unité des Pathologies du Sommeil, Hôpiral Pitié-Salpêtrière, APHP, and Inserm U975-CRICM-Pierre and Marie Curie University</s1><s2>Paris</s2><s3>FRA</s3><sZ>4 aut.</sZ><sZ>14 aut.</sZ></inist:fA14><country>France</country></affiliation></author><author><name sortKey="Frauscher, Birgit" sort="Frauscher, Birgit" uniqKey="Frauscher B" first="Birgit" last="Frauscher">Birgit Frauscher</name><affiliation wicri:level="1"><inist:fA14 i1="06"><s1>Department of Neurology, Innsbruck Medical University</s1><s2>Innsbruck</s2><s3>AUT</s3><sZ>5 aut.</sZ><sZ>15 aut.</sZ></inist:fA14><country>Autriche</country></affiliation></author><author><name sortKey="Terzaghi, Michele" sort="Terzaghi, Michele" uniqKey="Terzaghi M" first="Michele" last="Terzaghi">Michele Terzaghi</name><affiliation wicri:level="1"><inist:fA14 i1="07"><s1>Unit of Sleep Medicine, National Institute of Neurology IRCCS, C. Mondino, Foundation</s1><s2>Pavia</s2><s3>ITA</s3><sZ>6 aut.</sZ><sZ>16 aut.</sZ></inist:fA14><country>Italie</country></affiliation></author><author><name sortKey="Miyamoto, Masayuki" sort="Miyamoto, Masayuki" uniqKey="Miyamoto M" first="Masayuki" last="Miyamoto">Masayuki Miyamoto</name><affiliation wicri:level="1"><inist:fA14 i1="08"><s1>Department of Neurology, Dokkyo Medical University Koshigaya Hospital</s1><s2>Saitama</s2><s3>JPN</s3><sZ>7 aut.</sZ><sZ>17 aut.</sZ></inist:fA14><country>Japon</country></affiliation></author><author><name sortKey="Unger, Marcus" sort="Unger, Marcus" uniqKey="Unger M" first="Marcus" last="Unger">Marcus Unger</name><affiliation wicri:level="1"><inist:fA14 i1="09"><s1>Department of Neurology, Philipps-Universität</s1><s2>Marburg</s2><s3>DEU</s3><sZ>8 aut.</sZ><sZ>18 aut.</sZ></inist:fA14><country>Allemagne</country></affiliation><affiliation wicri:level="1"><inist:fA14 i1="14"><s1>Department of Neurology, Saarland University</s1><s2>Homburg/Saar</s2><s3>DEU</s3><sZ>18 aut.</sZ></inist:fA14><country>Allemagne</country></affiliation></author><author><name sortKey="Desautels, Alex" sort="Desautels, Alex" uniqKey="Desautels A" first="Alex" last="Desautels">Alex Desautels</name><affiliation wicri:level="1"><inist:fA14 i1="02"><s1>Centre d'Études Avancées en Médecine du Sommeil, Hôpiral du Sacré-Cœur de Montréal</s1><s2>Montréal</s2><s3>FRA</s3><sZ>2 aut.</sZ><sZ>19 aut.</sZ><sZ>22 aut.</sZ></inist:fA14><country>France</country></affiliation></author><author><name sortKey="Wolfson, Christina" sort="Wolfson, Christina" uniqKey="Wolfson C" first="Christina" last="Wolfson">Christina Wolfson</name><affiliation wicri:level="1"><inist:fA14 i1="15"><s1>Research Institute of the McGill University Health Center</s1><s2>Montreal</s2><s3>CAN</s3><sZ>20 aut.</sZ><sZ>21 aut.</sZ></inist:fA14><country>Canada</country></affiliation></author><author><name sortKey="Pelletier, Amelie" sort="Pelletier, Amelie" uniqKey="Pelletier A" first="Amélie" last="Pelletier">Amélie Pelletier</name><affiliation wicri:level="1"><inist:fA14 i1="15"><s1>Research Institute of the McGill University Health Center</s1><s2>Montreal</s2><s3>CAN</s3><sZ>20 aut.</sZ><sZ>21 aut.</sZ></inist:fA14><country>Canada</country></affiliation></author><author><name sortKey="Montplaisir, Jacques" sort="Montplaisir, Jacques" uniqKey="Montplaisir J" first="Jacques" last="Montplaisir">Jacques Montplaisir</name><affiliation wicri:level="1"><inist:fA14 i1="02"><s1>Centre d'Études Avancées en Médecine du Sommeil, Hôpiral du Sacré-Cœur de Montréal</s1><s2>Montréal</s2><s3>FRA</s3><sZ>2 aut.</sZ><sZ>19 aut.</sZ><sZ>22 aut.</sZ></inist:fA14><country>France</country></affiliation></author></analytic><series><title level="j" type="main">Neurology</title><title level="j" type="abbreviated">Neurology</title><idno type="ISSN">0028-3878</idno><imprint><date when="2013">2013</date></imprint></series></biblStruct></sourceDesc><seriesStmt><title level="j" type="main">Neurology</title><title level="j" type="abbreviated">Neurology</title><idno type="ISSN">0028-3878</idno></seriesStmt></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Behavior</term><term>Case control study</term><term>Idiopathic</term><term>Multicenter study</term><term>Nervous system diseases</term></keywords><keywords scheme="Pascal" xml:lang="fr"><term>Pathologie du système nerveux</term><term>Idiopathique</term><term>Comportement</term><term>Etude multicentrique</term><term>Etude cas témoin</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">Objective: To compare the frequency of proxy-reported REM sleep behavior disorder (RBD) among relatives of patients with polysomnogram-diagnosed idiopathic RBD (iRBD) in comparison to controls using a large multicenter clinic-based cohort. Methods: A total of 316 patients with polysomnography-confirmed iRBD were recruited from 12 RBD study group centers, along with 316 controls matched on sex and age group. All subjects completed a self-administered questionnaire that collected proxy-reported information on family history of tremor, gait trouble, balance trouble, Parkinson disease, memory loss, and Alzheimer disease. The questionnaire also included a single question that asked about possible symptoms of RBD among first-degree relatives (siblings, parents, and children). Results: A positive family history of dream enactment was reported in 13.8% of iRBD cases compared to 4.8% of controls (odds ratio [OR] = 3.9, 95% confidence interval [CI] 2.0-7.7). ORs were increased for both siblings (OR = 6.1, 95% CI 2.1-18.1) and parents (OR = 3.2, 95% CI 1.4-7.8). We found no significant difference in sex, current age (65.3 ± 10.2 vs 66.9 ± 10.2 years), or age at self-reported RBD onset (55.2 ± 11.7 vs 56.6 ± 15.1 years) in possible familial vs sporadic iRBD. No differences were found in family history of tremor, walking and balance troubles, Parkinson disease, memory loss, or Alzheimer disease. Conclusion: We found increased odds of proxy-reported family history of presumed RBD among individuals with confirmed iRBD. This suggests the possibility of a genetic contribution to RBD.</div></front></TEI><inist><standard h6="B"><pA><fA01 i1="01" i2="1"><s0>0028-3878</s0></fA01><fA02 i1="01"><s0>NEURAI</s0></fA02><fA03 i2="1"><s0>Neurology</s0></fA03><fA05><s2>80</s2></fA05><fA06><s2>24</s2></fA06><fA08 i1="01" i2="1" l="ENG"><s1>Family history of idiopathic REM behavior disorder: A multicenter case-control study</s1></fA08><fA11 i1="01" i2="1"><s1>DAUVILLIERS (Yves)</s1></fA11><fA11 i1="02" i2="1"><s1>POSTUMA (Ronald B.)</s1></fA11><fA11 i1="03" i2="1"><s1>FERINI-STRAMBI (Luigi)</s1></fA11><fA11 i1="04" i2="1"><s1>ARNULF (Isabelle)</s1></fA11><fA11 i1="05" i2="1"><s1>HÖGL (Birgit)</s1></fA11><fA11 i1="06" i2="1"><s1>MANNI (Raffaele)</s1></fA11><fA11 i1="07" i2="1"><s1>MIYAMOTO (Tomoyuki)</s1></fA11><fA11 i1="08" i2="1"><s1>OERTEL (Wolfgang)</s1></fA11><fA11 i1="09" i2="1"><s1>LIVIA FANTINI (Maria)</s1></fA11><fA11 i1="10" i2="1"><s1>PULIGHEDDU (Monica)</s1></fA11><fA11 i1="11" i2="1"><s1>JENNUM (Poul)</s1></fA11><fA11 i1="12" i2="1"><s1>SONKA (Karel)</s1></fA11><fA11 i1="13" i2="1"><s1>ZUCCONI (Marco)</s1></fA11><fA11 i1="14" i2="1"><s1>LEU-SEMENESCU (Smeranda)</s1></fA11><fA11 i1="15" i2="1"><s1>FRAUSCHER (Birgit)</s1></fA11><fA11 i1="16" i2="1"><s1>TERZAGHI (Michele)</s1></fA11><fA11 i1="17" i2="1"><s1>MIYAMOTO (Masayuki)</s1></fA11><fA11 i1="18" i2="1"><s1>UNGER (Marcus)</s1></fA11><fA11 i1="19" i2="1"><s1>DESAUTELS (Alex)</s1></fA11><fA11 i1="20" i2="1"><s1>WOLFSON (Christina)</s1></fA11><fA11 i1="21" i2="1"><s1>PELLETIER (Amélie)</s1></fA11><fA11 i1="22" i2="1"><s1>MONTPLAISIR (Jacques)</s1></fA11><fA14 i1="01"><s1>Department of Neurology, Hôpital Gui de Chauliac, Montpellier, INSERM U1061</s1><s2>Montpellier</s2><s3>FRA</s3><sZ>1 aut.</sZ></fA14><fA14 i1="02"><s1>Centre d'Études Avancées en Médecine du Sommeil, Hôpiral du Sacré-Cœur de Montréal</s1><s2>Montréal</s2><s3>FRA</s3><sZ>2 aut.</sZ><sZ>19 aut.</sZ><sZ>22 aut.</sZ></fA14><fA14 i1="03"><s1>Department of Neurology, McGill University, Montreal General Hospital</s1><s2>Montreal</s2><s3>CAN</s3><sZ>2 aut.</sZ></fA14><fA14 i1="04"><s1>Sleep Disorders Center, Università Vita-Salute San Raffaele</s1><s2>Milan</s2><s3>ITA</s3><sZ>3 aut.</sZ><sZ>13 aut.</sZ></fA14><fA14 i1="05"><s1>Unité des Pathologies du Sommeil, Hôpiral Pitié-Salpêtrière, APHP, and Inserm U975-CRICM-Pierre and Marie Curie University</s1><s2>Paris</s2><s3>FRA</s3><sZ>4 aut.</sZ><sZ>14 aut.</sZ></fA14><fA14 i1="06"><s1>Department of Neurology, Innsbruck Medical University</s1><s2>Innsbruck</s2><s3>AUT</s3><sZ>5 aut.</sZ><sZ>15 aut.</sZ></fA14><fA14 i1="07"><s1>Unit of Sleep Medicine, National Institute of Neurology IRCCS, C. Mondino, Foundation</s1><s2>Pavia</s2><s3>ITA</s3><sZ>6 aut.</sZ><sZ>16 aut.</sZ></fA14><fA14 i1="08"><s1>Department of Neurology, Dokkyo Medical University Koshigaya Hospital</s1><s2>Saitama</s2><s3>JPN</s3><sZ>7 aut.</sZ><sZ>17 aut.</sZ></fA14><fA14 i1="09"><s1>Department of Neurology, Philipps-Universität</s1><s2>Marburg</s2><s3>DEU</s3><sZ>8 aut.</sZ><sZ>18 aut.</sZ></fA14><fA14 i1="10"><s1>Sleep Disorders Center, Department of Neurosciences, University of Turin</s1><s2>Turin</s2><s3>ITA</s3><sZ>9 aut.</sZ></fA14><fA14 i1="11"><s1>Sleep Center, Department of Cardiovascular and Neurological Sciences, University of Cagliari</s1><s3>ITA</s3><sZ>10 aut.</sZ></fA14><fA14 i1="12"><s1>Danish Center for Sleep Medicine, University of Copenhagen</s1><s3>DNK</s3><sZ>11 aut.</sZ></fA14><fA14 i1="13"><s1>Department of Neurology First Faculty of Medicine, Charles University and General University Hospital</s1><s2>Prague</s2><s3>CZE</s3><sZ>12 aut.</sZ></fA14><fA14 i1="14"><s1>Department of Neurology, Saarland University</s1><s2>Homburg/Saar</s2><s3>DEU</s3><sZ>18 aut.</sZ></fA14><fA14 i1="15"><s1>Research Institute of the McGill University Health Center</s1><s2>Montreal</s2><s3>CAN</s3><sZ>20 aut.</sZ><sZ>21 aut.</sZ></fA14><fA20><s1>2233-2235</s1></fA20><fA21><s1>2013</s1></fA21><fA23 i1="01"><s0>ENG</s0></fA23><fA43 i1="01"><s1>INIST</s1><s2>6345</s2><s5>354000503092290120</s5></fA43><fA44><s0>0000</s0><s1>© 2013 INIST-CNRS. All rights reserved.</s1></fA44><fA45><s0>8 ref.</s0></fA45><fA47 i1="01" i2="1"><s0>13-0231441</s0></fA47><fA60><s1>P</s1></fA60><fA61><s0>A</s0></fA61><fA64 i1="01" i2="1"><s0>Neurology</s0></fA64><fA66 i1="01"><s0>USA</s0></fA66><fC01 i1="01" l="ENG"><s0>Objective: To compare the frequency of proxy-reported REM sleep behavior disorder (RBD) among relatives of patients with polysomnogram-diagnosed idiopathic RBD (iRBD) in comparison to controls using a large multicenter clinic-based cohort. Methods: A total of 316 patients with polysomnography-confirmed iRBD were recruited from 12 RBD study group centers, along with 316 controls matched on sex and age group. All subjects completed a self-administered questionnaire that collected proxy-reported information on family history of tremor, gait trouble, balance trouble, Parkinson disease, memory loss, and Alzheimer disease. The questionnaire also included a single question that asked about possible symptoms of RBD among first-degree relatives (siblings, parents, and children). Results: A positive family history of dream enactment was reported in 13.8% of iRBD cases compared to 4.8% of controls (odds ratio [OR] = 3.9, 95% confidence interval [CI] 2.0-7.7). ORs were increased for both siblings (OR = 6.1, 95% CI 2.1-18.1) and parents (OR = 3.2, 95% CI 1.4-7.8). We found no significant difference in sex, current age (65.3 ± 10.2 vs 66.9 ± 10.2 years), or age at self-reported RBD onset (55.2 ± 11.7 vs 56.6 ± 15.1 years) in possible familial vs sporadic iRBD. No differences were found in family history of tremor, walking and balance troubles, Parkinson disease, memory loss, or Alzheimer disease. Conclusion: We found increased odds of proxy-reported family history of presumed RBD among individuals with confirmed iRBD. This suggests the possibility of a genetic contribution to RBD.</s0></fC01><fC02 i1="01" i2="X"><s0>002B17</s0></fC02><fC02 i1="02" i2="X"><s0>002B17E</s0></fC02><fC03 i1="01" i2="X" l="FRE"><s0>Pathologie du système nerveux</s0><s5>01</s5></fC03><fC03 i1="01" i2="X" l="ENG"><s0>Nervous system diseases</s0><s5>01</s5></fC03><fC03 i1="01" i2="X" l="SPA"><s0>Sistema nervioso patología</s0><s5>01</s5></fC03><fC03 i1="02" i2="X" l="FRE"><s0>Idiopathique</s0><s5>09</s5></fC03><fC03 i1="02" i2="X" l="ENG"><s0>Idiopathic</s0><s5>09</s5></fC03><fC03 i1="02" i2="X" l="SPA"><s0>Idiopático</s0><s5>09</s5></fC03><fC03 i1="03" i2="X" l="FRE"><s0>Comportement</s0><s5>10</s5></fC03><fC03 i1="03" i2="X" l="ENG"><s0>Behavior</s0><s5>10</s5></fC03><fC03 i1="03" i2="X" l="SPA"><s0>Conducta</s0><s5>10</s5></fC03><fC03 i1="04" i2="X" l="FRE"><s0>Etude multicentrique</s0><s5>11</s5></fC03><fC03 i1="04" i2="X" l="ENG"><s0>Multicenter study</s0><s5>11</s5></fC03><fC03 i1="04" i2="X" l="SPA"><s0>Estudio multicéntrico</s0><s5>11</s5></fC03><fC03 i1="05" i2="X" l="FRE"><s0>Etude cas témoin</s0><s5>12</s5></fC03><fC03 i1="05" i2="X" l="ENG"><s0>Case control study</s0><s5>12</s5></fC03><fC03 i1="05" i2="X" l="SPA"><s0>Estudio caso control</s0><s5>12</s5></fC03><fN21><s1>217</s1></fN21><fN44 i1="01"><s1>OTO</s1></fN44><fN82><s1>OTO</s1></fN82></pA></standard></inist></record>Pour manipuler ce document sous Unix (Dilib)
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