ParkinsonCanadaV1, PascalFrancis, Curation, bibRecord, 000A31

Defective dentate nucleus GABA receptors in essential tremor

Identifieur interne : 000A31 ( PascalFrancis/Curation ); précédent : 000A30; suivant : 000A32

Defective dentate nucleus GABA receptors in essential tremor

Auteurs : Sarah Paris-Robidas [Canada] ; Elodie Brochu [Canada] ; Marion Sintes [Canada] ; Vincent Emond [Canada] ; Mélanie Bousquet [Canada] ; Milène Vandal [Canada] ; Mireille Pilote [Canada] ; Cyntia Tremblay [Canada] ; Therese Di Paolo [Canada] ; Ali H. Rajput [Canada] ; Alex Rajput [Canada] ; Frederic Calon [Canada]

Source :

Brain [ 0006-8950 ] ; 2012.

RBID : Pascal:12-0113652

Descripteurs français

Pascal (Inist)
- Tremblement, Pathologie du système nerveux, Noyau dentelé, Récepteur gabaergique, Cervelet.

English descriptors

KwdEn :
- Cerebellum, Dentate nucleus, Gabaergic receptor, Nervous system diseases, Tremor.

Abstract

The development of new treatments for essential tremor, the most frequent movement disorder, is limited by a poor unde standing of its pathophysiology and the relative paucity of clinicopathological studies. Here, we report a post-mortem decrease in GABA_A (35% reduction) and GABA_B (22-31 % reduction) receptors in the dentate nucleus of the cerebellum from individua with essential tremor, compared with controls or individuals with Parkinson's disease, as assessed by receptor-binding auti radiography. Concentrations of GABA_B receptors in the dentate nucleus were inversely correlated with the duration of essenti tremor symptoms (r² = 0.44, P < 0.05), suggesting that the loss of GABA_B receptors follows the progression of the disease. situ hybridization experiments also revealed a diminution of GABA_B(1a+b) receptor messenger RNA in essential tremor (↓27%). In contrast, no significant changes of GABA_A and GABA_B receptors (protein and messenger RNA), GluN2B receptors, cytochrorr oxidase-1 or GABA concentrations were detected in molecular or granular layers of the cerebellar cortex. It is proposed that decrease in GABA receptors in the dentate nucleus results in disinhibition of cerebellar pacemaker output activity, propagatir along the cerebello-thalamo-cortical pathways to generate tremors. Correction of such defective cerebellar GABAergic drive could have a therapeutic effect in essential tremor.

A01	`01`	`1`		`@0 0006-8950`
A03		`1`		`@0 Brain`
A05				`@2 135`
A06				`@3 p. 1`
A08	`01`	`1`	`ENG`	`@1 Defective dentate nucleus GABA receptors in essential tremor`
A11	`01`	`1`		`@1 PARIS-ROBIDAS (Sarah)`
A11	`02`	`1`		`@1 BROCHU (Elodie)`
A11	`03`	`1`		`@1 SINTES (Marion)`
A11	`04`	`1`		`@1 EMOND (Vincent)`
A11	`05`	`1`		`@1 BOUSQUET (Mélanie)`
A11	`06`	`1`		`@1 VANDAL (Milène)`
A11	`07`	`1`		`@1 PILOTE (Mireille)`
A11	`08`	`1`		`@1 TREMBLAY (Cyntia)`
A11	`09`	`1`		`@1 DI PAOLO (Therese)`
A11	`10`	`1`		`@1 RAJPUT (Ali H.)`
A11	`11`	`1`		`@1 RAJPUT (Alex)`
A11	`12`	`1`		`@1 CALON (Frederic)`
A14	`01`			`@1 Faculty of Pharmacy, Laval University @2 Quebec, QC G1V 0A6 @3 CAN @Z 1 aut. @Z 2 aut. @Z 3 aut. @Z 4 aut. @Z 5 aut. @Z 6 aut. @Z 7 aut. @Z 8 aut. @Z 9 aut. @Z 12 aut.`
A14	`02`			`@1 Centre Hospitalier de l'Université Laval (CHUL) Research Centre @2 Quebec, QC G1V 4G2 @3 CAN @Z 1 aut. @Z 2 aut. @Z 3 aut. @Z 4 aut. @Z 5 aut. @Z 6 aut. @Z 7 aut. @Z 8 aut. @Z 9 aut. @Z 12 aut.`
A14	`03`			`@1 Division of Neurology, Royal University Hospital, University of Saskatchewan @2 Saskatoon, SK S7N 0W8 @3 CAN @Z 10 aut. @Z 11 aut.`
A20				`@1 105-116`
A21				`@1 2012`
A23	`01`			`@0 ENG`
A43	`01`			`@1 INIST @2 998 @5 354000508404210090`
A44				`@0 0000 @1 © 2012 INIST-CNRS. All rights reserved.`
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A47	`01`	`1`		`@0 12-0113652`
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A64	`01`	`1`		`@0 Brain`
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C01	`01`		`ENG`	@0 The development of new treatments for essential tremor, the most frequent movement disorder, is limited by a poor unde standing of its pathophysiology and the relative paucity of clinicopathological studies. Here, we report a post-mortem decrease in GABA_A (35% reduction) and GABA_B (22-31 % reduction) receptors in the dentate nucleus of the cerebellum from individua with essential tremor, compared with controls or individuals with Parkinson's disease, as assessed by receptor-binding auti radiography. Concentrations of GABA_B receptors in the dentate nucleus were inversely correlated with the duration of essenti tremor symptoms (r² = 0.44, P < 0.05), suggesting that the loss of GABA_B receptors follows the progression of the disease. situ hybridization experiments also revealed a diminution of GABA_B(1a+b) receptor messenger RNA in essential tremor (↓27%). In contrast, no significant changes of GABA_A and GABA_B receptors (protein and messenger RNA), GluN2B receptors, cytochrorr oxidase-1 or GABA concentrations were detected in molecular or granular layers of the cerebellar cortex. It is proposed that decrease in GABA receptors in the dentate nucleus results in disinhibition of cerebellar pacemaker output activity, propagatir along the cerebello-thalamo-cortical pathways to generate tremors. Correction of such defective cerebellar GABAergic drive could have a therapeutic effect in essential tremor.
C02	`01`	`X`		`@0 002B17`
C02	`02`	`X`		`@0 002B17A03`
C03	`01`	`X`	`FRE`	`@0 Tremblement @5 01`
C03	`01`	`X`	`ENG`	`@0 Tremor @5 01`
C03	`01`	`X`	`SPA`	`@0 Temblor @5 01`
C03	`02`	`X`	`FRE`	`@0 Pathologie du système nerveux @5 02`
C03	`02`	`X`	`ENG`	`@0 Nervous system diseases @5 02`
C03	`02`	`X`	`SPA`	`@0 Sistema nervioso patología @5 02`
C03	`03`	`X`	`FRE`	`@0 Noyau dentelé @5 09`
C03	`03`	`X`	`ENG`	`@0 Dentate nucleus @5 09`
C03	`03`	`X`	`SPA`	`@0 Núcleo dentado @5 09`
C03	`04`	`X`	`FRE`	`@0 Récepteur gabaergique @5 10`
C03	`04`	`X`	`ENG`	`@0 Gabaergic receptor @5 10`
C03	`04`	`X`	`SPA`	`@0 Receptor gabaminérgico @5 10`
C03	`05`	`X`	`FRE`	`@0 Cervelet @5 11`
C03	`05`	`X`	`ENG`	`@0 Cerebellum @5 11`
C03	`05`	`X`	`SPA`	`@0 Cerebelo @5 11`
C07	`01`	`X`	`FRE`	`@0 Encéphale @5 37`
C07	`01`	`X`	`ENG`	`@0 Encephalon @5 37`
C07	`01`	`X`	`SPA`	`@0 Encéfalo @5 37`
C07	`02`	`X`	`FRE`	`@0 Système nerveux central @5 38`
C07	`02`	`X`	`ENG`	`@0 Central nervous system @5 38`
C07	`02`	`X`	`SPA`	`@0 Sistema nervioso central @5 38`
C07	`03`	`X`	`FRE`	`@0 Mouvement involontaire @5 39`
C07	`03`	`X`	`ENG`	`@0 Involuntary movement @5 39`
C07	`03`	`X`	`SPA`	`@0 Movimiento involuntario @5 39`
C07	`04`	`X`	`FRE`	`@0 Trouble neurologique @5 41`
C07	`04`	`X`	`ENG`	`@0 Neurological disorder @5 41`
C07	`04`	`X`	`SPA`	`@0 Trastorno neurológico @5 41`
N21				`@1 086`
N44	`01`			`@1 OTO`
N82				`@1 OTO`

Links toward previous steps (curation, corpus...)

to stream PascalFrancis, to step Corpus: Pour aller vers cette notice dans l'étape Curation :000221

Links to Exploration step

Pascal:12-0113652

Le document en format XML

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<author><name sortKey="Rajput, Ali H" sort="Rajput, Ali H" uniqKey="Rajput A" first="Ali H." last="Rajput">Ali H. Rajput</name>
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<author><name sortKey="Rajput, Alex" sort="Rajput, Alex" uniqKey="Rajput A" first="Alex" last="Rajput">Alex Rajput</name>
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<author><name sortKey="Calon, Frederic" sort="Calon, Frederic" uniqKey="Calon F" first="Frederic" last="Calon">Frederic Calon</name>
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<publicationStmt><idno type="wicri:source">INIST</idno>
<idno type="inist">12-0113652</idno>
<date when="2012">2012</date>
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<series><title level="j" type="main">Brain</title>
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<profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Cerebellum</term>
<term>Dentate nucleus</term>
<term>Gabaergic receptor</term>
<term>Nervous system diseases</term>
<term>Tremor</term>
</keywords>
<keywords scheme="Pascal" xml:lang="fr"><term>Tremblement</term>
<term>Pathologie du   système nerveux</term>
<term>Noyau dentelé</term>
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<front><div type="abstract" xml:lang="en">The development of new treatments for essential tremor, the most frequent movement disorder, is limited by a poor unde standing of its pathophysiology and the relative paucity of clinicopathological studies. Here, we report a post-mortem decrease in GABA<sub>A</sub>
 (35% reduction) and GABA<sub>B</sub>
 (22-31 % reduction) receptors in the dentate nucleus of the cerebellum from individua with essential tremor, compared with controls or individuals with Parkinson's disease, as assessed by receptor-binding auti radiography. Concentrations of GABA<sub>B</sub>
 receptors in the dentate nucleus were inversely correlated with the duration of essenti tremor symptoms (r<sup>2</sup>
 = 0.44, P < 0.05), suggesting that the loss of GABA<sub>B</sub>
 receptors follows the progression of the disease. situ hybridization experiments also revealed a diminution of GABA<sub>B(1a+b)</sub>
 receptor messenger RNA in essential tremor (↓27%). In contrast, no significant changes of GABA<sub>A</sub>
 and GABA<sub>B</sub>
 receptors (protein and messenger RNA), GluN2B receptors, cytochrorr oxidase-1 or GABA concentrations were detected in molecular or granular layers of the cerebellar cortex. It is proposed that decrease in GABA receptors in the dentate nucleus results in disinhibition of cerebellar pacemaker output activity, propagatir along the cerebello-thalamo-cortical pathways to generate tremors. Correction of such defective cerebellar GABAergic drive could have a therapeutic effect in essential tremor.</div>
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 (35% reduction) and GABA<sub>B</sub>
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 and GABA<sub>B</sub>
 receptors (protein and messenger RNA), GluN2B receptors, cytochrorr oxidase-1 or GABA concentrations were detected in molecular or granular layers of the cerebellar cortex. It is proposed that decrease in GABA receptors in the dentate nucleus results in disinhibition of cerebellar pacemaker output activity, propagatir along the cerebello-thalamo-cortical pathways to generate tremors. Correction of such defective cerebellar GABAergic drive could have a therapeutic effect in essential tremor.</s0>
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<s5>01</s5>
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<fC03 i1="01" i2="X" l="ENG"><s0>Tremor</s0>
<s5>01</s5>
</fC03>
<fC03 i1="01" i2="X" l="SPA"><s0>Temblor</s0>
<s5>01</s5>
</fC03>
<fC03 i1="02" i2="X" l="FRE"><s0>Pathologie du   système nerveux</s0>
<s5>02</s5>
</fC03>
<fC03 i1="02" i2="X" l="ENG"><s0>Nervous system diseases</s0>
<s5>02</s5>
</fC03>
<fC03 i1="02" i2="X" l="SPA"><s0>Sistema nervioso patología</s0>
<s5>02</s5>
</fC03>
<fC03 i1="03" i2="X" l="FRE"><s0>Noyau dentelé</s0>
<s5>09</s5>
</fC03>
<fC03 i1="03" i2="X" l="ENG"><s0>Dentate nucleus</s0>
<s5>09</s5>
</fC03>
<fC03 i1="03" i2="X" l="SPA"><s0>Núcleo dentado</s0>
<s5>09</s5>
</fC03>
<fC03 i1="04" i2="X" l="FRE"><s0>Récepteur gabaergique</s0>
<s5>10</s5>
</fC03>
<fC03 i1="04" i2="X" l="ENG"><s0>Gabaergic receptor</s0>
<s5>10</s5>
</fC03>
<fC03 i1="04" i2="X" l="SPA"><s0>Receptor gabaminérgico</s0>
<s5>10</s5>
</fC03>
<fC03 i1="05" i2="X" l="FRE"><s0>Cervelet</s0>
<s5>11</s5>
</fC03>
<fC03 i1="05" i2="X" l="ENG"><s0>Cerebellum</s0>
<s5>11</s5>
</fC03>
<fC03 i1="05" i2="X" l="SPA"><s0>Cerebelo</s0>
<s5>11</s5>
</fC03>
<fC07 i1="01" i2="X" l="FRE"><s0>Encéphale</s0>
<s5>37</s5>
</fC07>
<fC07 i1="01" i2="X" l="ENG"><s0>Encephalon</s0>
<s5>37</s5>
</fC07>
<fC07 i1="01" i2="X" l="SPA"><s0>Encéfalo</s0>
<s5>37</s5>
</fC07>
<fC07 i1="02" i2="X" l="FRE"><s0>Système nerveux central</s0>
<s5>38</s5>
</fC07>
<fC07 i1="02" i2="X" l="ENG"><s0>Central nervous system</s0>
<s5>38</s5>
</fC07>
<fC07 i1="02" i2="X" l="SPA"><s0>Sistema nervioso central</s0>
<s5>38</s5>
</fC07>
<fC07 i1="03" i2="X" l="FRE"><s0>Mouvement involontaire</s0>
<s5>39</s5>
</fC07>
<fC07 i1="03" i2="X" l="ENG"><s0>Involuntary movement</s0>
<s5>39</s5>
</fC07>
<fC07 i1="03" i2="X" l="SPA"><s0>Movimiento involuntario</s0>
<s5>39</s5>
</fC07>
<fC07 i1="04" i2="X" l="FRE"><s0>Trouble neurologique</s0>
<s5>41</s5>
</fC07>
<fC07 i1="04" i2="X" l="ENG"><s0>Neurological disorder</s0>
<s5>41</s5>
</fC07>
<fC07 i1="04" i2="X" l="SPA"><s0>Trastorno neurológico</s0>
<s5>41</s5>
</fC07>
<fN21><s1>086</s1>
</fN21>
<fN44 i1="01"><s1>OTO</s1>
</fN44>
<fN82><s1>OTO</s1>
</fN82>
</pA>
</standard>
</inist>
</record>

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This area was generated with Dilib version V0.6.29.
Data generation: Thu May 4 22:20:19 2017. Site generation: Fri Dec 23 23:17:26 2022

	La maladie de Parkinson au Canada (serveur d'exploration)
	Attention, ce site est en cours de développement ! Attention, site généré par des moyens informatiques à partir de corpus bruts. Les informations ne sont donc pas validées.

La maladie de Parkinson au Canada (serveur d'exploration)

Defective dentate nucleus GABA receptors in essential tremor

Defective dentate nucleus GABA receptors in essential tremor

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