Intra- and inter-limb coherency during stance in non-dyskinetic and dyskinetic patients with Parkinson's disease
Identifieur interne : 000843 ( PascalFrancis/Curation ); précédent : 000842; suivant : 000844Intra- and inter-limb coherency during stance in non-dyskinetic and dyskinetic patients with Parkinson's disease
Auteurs : Rena K. Mann [Canada] ; Roderick Edwards [Canada] ; Julie Zhou [Canada] ; Mandar Jog [Canada] ; Christian Duval [Canada]Source :
- Clinical neurology and neurosurgery [ 0303-8467 ] ; 2010.
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Abstract
Objective: Examine the level of intra- and inter-limb coherency in non-dyskinetic and dyskinetic patients with Parkinson's disease (PD). Patients & Methods: Using a magnetic tracking system, whole-body 3D movements were assessed in 10 dyskinetic patients with clear monophasic peak-dose levodopa-induced dyskinesia (LID), in 10 non-dyskinetic patients and in 10 control subjects, standing with their arms out. Patients were tested during their best ON period. Coherency in the kinematics of pairs of body segments was assessed by spectral analysis. For each pair examined, we calculated the highest coherency between 0.5 and 3.0 Hz and the frequency at which this maximum coherency occurred. Results: Analysis of variance showed that for 34 out of the 44 (77.3%) comparisons we studied, there were significant differences between the means of coherencies of the groups. Typically, the control group had the highest coherency and the patients with LID had the lowest. Patients with LID also tended to have their maximum coherency at higher frequencies than the control and non-dyskinetic patient groups (30 out of 44 comparisons were significant). These trends appeared in all types of inter-segment comparisons, including bilaterally symmetric segments, biomechanically linked segments (in which coherencies were higher overall in all groups, but still different between groups) and in other comparisons, but the trends were not so clear for comparisons involving the feet. Conclusion: LID is indeed incoherent in the frequency domain, suggesting that body segments may be driven by different neural outputs. The challenges of dealing with these incoherent involuntary movements when planning and executing voluntary movements must certainly play a role in motor difficulties observed in patients with LID. The fact that both dyskinetic and non-dyskinetic patients showed less coherency than controls suggests that levodopa may alter postural control by decreasing stiffness and increasing limb independence.
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<record><TEI><teiHeader><fileDesc><titleStmt><title xml:lang="en" level="a">Intra- and inter-limb coherency during stance in non-dyskinetic and dyskinetic patients with Parkinson's disease</title><author><name sortKey="Mann, Rena K" sort="Mann, Rena K" uniqKey="Mann R" first="Rena K." last="Mann">Rena K. Mann</name><affiliation wicri:level="1"><inist:fA14 i1="01"><s1>Dept. of Mathematics & Statistics, University of Victoria</s1><s2>Victoria, British Columbia</s2><s3>CAN</s3><sZ>1 aut.</sZ><sZ>2 aut.</sZ><sZ>3 aut.</sZ></inist:fA14><country>Canada</country></affiliation></author><author><name sortKey="Edwards, Roderick" sort="Edwards, Roderick" uniqKey="Edwards R" first="Roderick" last="Edwards">Roderick Edwards</name><affiliation wicri:level="1"><inist:fA14 i1="01"><s1>Dept. of Mathematics & Statistics, University of Victoria</s1><s2>Victoria, British Columbia</s2><s3>CAN</s3><sZ>1 aut.</sZ><sZ>2 aut.</sZ><sZ>3 aut.</sZ></inist:fA14><country>Canada</country></affiliation></author><author><name sortKey="Zhou, Julie" sort="Zhou, Julie" uniqKey="Zhou J" first="Julie" last="Zhou">Julie Zhou</name><affiliation wicri:level="1"><inist:fA14 i1="01"><s1>Dept. of Mathematics & Statistics, University of Victoria</s1><s2>Victoria, British Columbia</s2><s3>CAN</s3><sZ>1 aut.</sZ><sZ>2 aut.</sZ><sZ>3 aut.</sZ></inist:fA14><country>Canada</country></affiliation></author><author><name sortKey="Jog, Mandar" sort="Jog, Mandar" uniqKey="Jog M" first="Mandar" last="Jog">Mandar Jog</name><affiliation wicri:level="1"><inist:fA14 i1="02"><s1>Clinical Neurological Sciences, University of Western Ontario Health Centre-University Hospital</s1><s2>London, Ontario</s2><s3>CAN</s3><sZ>4 aut.</sZ></inist:fA14><country>Canada</country></affiliation></author><author><name sortKey="Duval, Christian" sort="Duval, Christian" uniqKey="Duval C" first="Christian" last="Duval">Christian Duval</name><affiliation wicri:level="1"><inist:fA14 i1="03"><s1>Département de Kinanthropologie, Université du Québec à Montreal, C.P. 8888, Succursale Centre-Ville</s1><s2>Montréal (Québec)H3C 3P8</s2><s3>CAN</s3><sZ>5 aut.</sZ></inist:fA14><country>Canada</country></affiliation></author></titleStmt><publicationStmt><idno type="wicri:source">INIST</idno><idno type="inist">10-0277312</idno><date when="2010">2010</date><idno type="stanalyst">PASCAL 10-0277312 INIST</idno><idno type="RBID">Pascal:10-0277312</idno><idno type="wicri:Area/PascalFrancis/Corpus">000434</idno><idno type="wicri:Area/PascalFrancis/Curation">000843</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en" level="a">Intra- and inter-limb coherency during stance in non-dyskinetic and dyskinetic patients with Parkinson's disease</title><author><name sortKey="Mann, Rena K" sort="Mann, Rena K" uniqKey="Mann R" first="Rena K." last="Mann">Rena K. Mann</name><affiliation wicri:level="1"><inist:fA14 i1="01"><s1>Dept. of Mathematics & Statistics, University of Victoria</s1><s2>Victoria, British Columbia</s2><s3>CAN</s3><sZ>1 aut.</sZ><sZ>2 aut.</sZ><sZ>3 aut.</sZ></inist:fA14><country>Canada</country></affiliation></author><author><name sortKey="Edwards, Roderick" sort="Edwards, Roderick" uniqKey="Edwards R" first="Roderick" last="Edwards">Roderick Edwards</name><affiliation wicri:level="1"><inist:fA14 i1="01"><s1>Dept. of Mathematics & Statistics, University of Victoria</s1><s2>Victoria, British Columbia</s2><s3>CAN</s3><sZ>1 aut.</sZ><sZ>2 aut.</sZ><sZ>3 aut.</sZ></inist:fA14><country>Canada</country></affiliation></author><author><name sortKey="Zhou, Julie" sort="Zhou, Julie" uniqKey="Zhou J" first="Julie" last="Zhou">Julie Zhou</name><affiliation wicri:level="1"><inist:fA14 i1="01"><s1>Dept. of Mathematics & Statistics, University of Victoria</s1><s2>Victoria, British Columbia</s2><s3>CAN</s3><sZ>1 aut.</sZ><sZ>2 aut.</sZ><sZ>3 aut.</sZ></inist:fA14><country>Canada</country></affiliation></author><author><name sortKey="Jog, Mandar" sort="Jog, Mandar" uniqKey="Jog M" first="Mandar" last="Jog">Mandar Jog</name><affiliation wicri:level="1"><inist:fA14 i1="02"><s1>Clinical Neurological Sciences, University of Western Ontario Health Centre-University Hospital</s1><s2>London, Ontario</s2><s3>CAN</s3><sZ>4 aut.</sZ></inist:fA14><country>Canada</country></affiliation></author><author><name sortKey="Duval, Christian" sort="Duval, Christian" uniqKey="Duval C" first="Christian" last="Duval">Christian Duval</name><affiliation wicri:level="1"><inist:fA14 i1="03"><s1>Département de Kinanthropologie, Université du Québec à Montreal, C.P. 8888, Succursale Centre-Ville</s1><s2>Montréal (Québec)H3C 3P8</s2><s3>CAN</s3><sZ>5 aut.</sZ></inist:fA14><country>Canada</country></affiliation></author></analytic><series><title level="j" type="main">Clinical neurology and neurosurgery</title><title level="j" type="abbreviated">Clin. neurol. neurosurg.</title><idno type="ISSN">0303-8467</idno><imprint><date when="2010">2010</date></imprint></series></biblStruct></sourceDesc><seriesStmt><title level="j" type="main">Clinical neurology and neurosurgery</title><title level="j" type="abbreviated">Clin. neurol. neurosurg.</title><idno type="ISSN">0303-8467</idno></seriesStmt></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Dyskinesia</term><term>Human</term><term>Involuntary movement</term><term>Levodopa</term><term>Nervous system diseases</term><term>Parkinson disease</term><term>Surgery</term></keywords><keywords scheme="Pascal" xml:lang="fr"><term>Maladie de Parkinson</term><term>Dyskinésie</term><term>Mouvement involontaire</term><term>Pathologie du système nerveux</term><term>Homme</term><term>Lévodopa</term><term>Chirurgie</term></keywords><keywords scheme="Wicri" type="topic" xml:lang="fr"><term>Homme</term><term>Chirurgie</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">Objective: Examine the level of intra- and inter-limb coherency in non-dyskinetic and dyskinetic patients with Parkinson's disease (PD). Patients & Methods: Using a magnetic tracking system, whole-body 3D movements were assessed in 10 dyskinetic patients with clear monophasic peak-dose levodopa-induced dyskinesia (LID), in 10 non-dyskinetic patients and in 10 control subjects, standing with their arms out. Patients were tested during their best ON period. Coherency in the kinematics of pairs of body segments was assessed by spectral analysis. For each pair examined, we calculated the highest coherency between 0.5 and 3.0 Hz and the frequency at which this maximum coherency occurred. Results: Analysis of variance showed that for 34 out of the 44 (77.3%) comparisons we studied, there were significant differences between the means of coherencies of the groups. Typically, the control group had the highest coherency and the patients with LID had the lowest. Patients with LID also tended to have their maximum coherency at higher frequencies than the control and non-dyskinetic patient groups (30 out of 44 comparisons were significant). These trends appeared in all types of inter-segment comparisons, including bilaterally symmetric segments, biomechanically linked segments (in which coherencies were higher overall in all groups, but still different between groups) and in other comparisons, but the trends were not so clear for comparisons involving the feet. Conclusion: LID is indeed incoherent in the frequency domain, suggesting that body segments may be driven by different neural outputs. The challenges of dealing with these incoherent involuntary movements when planning and executing voluntary movements must certainly play a role in motor difficulties observed in patients with LID. The fact that both dyskinetic and non-dyskinetic patients showed less coherency than controls suggests that levodopa may alter postural control by decreasing stiffness and increasing limb independence.</div></front></TEI><inist><standard h6="B"><pA><fA01 i1="01" i2="1"><s0>0303-8467</s0></fA01><fA02 i1="01"><s0>CNNSBV</s0></fA02><fA03 i2="1"><s0>Clin. neurol. neurosurg.</s0></fA03><fA05><s2>112</s2></fA05><fA06><s2>5</s2></fA06><fA08 i1="01" i2="1" l="ENG"><s1>Intra- and inter-limb coherency during stance in non-dyskinetic and dyskinetic patients with Parkinson's disease</s1></fA08><fA11 i1="01" i2="1"><s1>MANN (Rena K.)</s1></fA11><fA11 i1="02" i2="1"><s1>EDWARDS (Roderick)</s1></fA11><fA11 i1="03" i2="1"><s1>ZHOU (Julie)</s1></fA11><fA11 i1="04" i2="1"><s1>JOG (Mandar)</s1></fA11><fA11 i1="05" i2="1"><s1>DUVAL (Christian)</s1></fA11><fA14 i1="01"><s1>Dept. of Mathematics & Statistics, University of Victoria</s1><s2>Victoria, British Columbia</s2><s3>CAN</s3><sZ>1 aut.</sZ><sZ>2 aut.</sZ><sZ>3 aut.</sZ></fA14><fA14 i1="02"><s1>Clinical Neurological Sciences, University of Western Ontario Health Centre-University Hospital</s1><s2>London, Ontario</s2><s3>CAN</s3><sZ>4 aut.</sZ></fA14><fA14 i1="03"><s1>Département de Kinanthropologie, Université du Québec à Montreal, C.P. 8888, Succursale Centre-Ville</s1><s2>Montréal (Québec)H3C 3P8</s2><s3>CAN</s3><sZ>5 aut.</sZ></fA14><fA20><s1>392-399</s1></fA20><fA21><s1>2010</s1></fA21><fA23 i1="01"><s0>ENG</s0></fA23><fA43 i1="01"><s1>INIST</s1><s2>4348</s2><s5>354000192988850030</s5></fA43><fA44><s0>0000</s0><s1>© 2010 INIST-CNRS. 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Results: Analysis of variance showed that for 34 out of the 44 (77.3%) comparisons we studied, there were significant differences between the means of coherencies of the groups. Typically, the control group had the highest coherency and the patients with LID had the lowest. Patients with LID also tended to have their maximum coherency at higher frequencies than the control and non-dyskinetic patient groups (30 out of 44 comparisons were significant). These trends appeared in all types of inter-segment comparisons, including bilaterally symmetric segments, biomechanically linked segments (in which coherencies were higher overall in all groups, but still different between groups) and in other comparisons, but the trends were not so clear for comparisons involving the feet. Conclusion: LID is indeed incoherent in the frequency domain, suggesting that body segments may be driven by different neural outputs. The challenges of dealing with these incoherent involuntary movements when planning and executing voluntary movements must certainly play a role in motor difficulties observed in patients with LID. 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