ParkinsonCanadaV1, PascalFrancis, Curation, bibRecord, 000744

Increased striatal dopamine release in Parkinsonian patients with pathological gambling : a [11C] raclopride PET study

Identifieur interne : 000744 ( PascalFrancis/Curation ); précédent : 000743; suivant : 000745

Increased striatal dopamine release in Parkinsonian patients with pathological gambling : a [11C] raclopride PET study

Auteurs : T. D. L. Steeves [Canada] ; J. Miyasaki [Canada] ; M. Zurowski [Canada] ; A. E. Lang [Canada] ; G. Pellecchia [Canada] ; T. Van Eimeren [Canada] ; P. Rusjan [Canada] ; S. Houle [Canada] ; A. P. Strafella [Canada]

Source :

Brain [ 0006-8950 ] ; 2009.

RBID : Pascal:09-0220633

Descripteurs français

Pascal (Inist)
- Maladie de Parkinson, Jeu pathologique, Trouble du contrôle des impulsions, Pathologie du système nerveux, Dopamine, Libération, Homme, Raclopride, Tomoscintigraphie, Tomographie par émission de positons, Imagerie fonctionnelle.
Wicri :
- topic : Homme.

English descriptors

KwdEn :
- Dopamine, Emission tomography, Functional imaging, Human, Impulse control disorder, Nervous system diseases, Parkinson disease, Pathological gambling, Positron emission tomography, Raclopride, Release.

Abstract

Pathological gambling is an impulse control disorder reported in association with dopamine agonists used to treat Parkinson's disease. Although impulse control disorders are conceptualized as lying within the spectrum of addictions, little neurobiological evidence exists to support this belief. Functional imaging studies have consistently demonstrated abnormalities of dopaminergic function in patients with drug addictions, but to date no study has specifically evaluated dopaminergic function in Parkinson's disease patients with impulse control disorders. We describe results of a [¹¹C] raclopride positron emission tomography (PET) study comparing dopaminergic function during gambling in Parkinson's disease patients, with and without pathological gambling, following dopamine agonists. Patients with pathological gambling demonstrated greater decreases in binding potential in the ventral striatum during gambling (13.9%) than control patients (8.1%), likely reflecting greater dopaminergic release. Ventral striatal bindings at baseline during control task were also lower in patients with pathological gambling. Although prior imaging studies suggest that abnormality in dopaminergic binding and dopamine release may be markers of vulnerability to addiction, this study presents the first evidence of these phenomena in pathological gambling. The emergence of pathological gambling in a number of Parkinson's disease patients may provide a model into the pathophysiology of this disorder.

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Pascal:09-0220633

Le document en format XML

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<author><name sortKey="Strafella, A P" sort="Strafella, A P" uniqKey="Strafella A" first="A. P." last="Strafella">A. P. Strafella</name>
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<affiliation wicri:level="1"><inist:fA14 i1="02"><s1>PET Imaging Centre, Centre for Addiction and Mental Health</s1>
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<country>Canada</country>
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<term>Emission tomography</term>
<term>Functional imaging</term>
<term>Human</term>
<term>Impulse control disorder</term>
<term>Nervous system diseases</term>
<term>Parkinson disease</term>
<term>Pathological gambling</term>
<term>Positron emission tomography</term>
<term>Raclopride</term>
<term>Release</term>
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<keywords scheme="Pascal" xml:lang="fr"><term>Maladie de Parkinson</term>
<term>Jeu pathologique</term>
<term>Trouble du contrôle des impulsions</term>
<term>Pathologie du   système nerveux</term>
<term>Dopamine</term>
<term>Libération</term>
<term>Homme</term>
<term>Raclopride</term>
<term>Tomoscintigraphie</term>
<term>Tomographie par émission de positons</term>
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<front><div type="abstract" xml:lang="en">Pathological gambling is an impulse control disorder reported in association with dopamine agonists used to treat Parkinson's disease. Although impulse control disorders are conceptualized as lying within the spectrum of addictions, little neurobiological evidence exists to support this belief. Functional imaging studies have consistently demonstrated abnormalities of dopaminergic function in patients with drug addictions, but to date no study has specifically evaluated dopaminergic function in Parkinson's disease patients with impulse control disorders. We describe results of a [<sup>11</sup>
C] raclopride positron emission tomography (PET) study comparing dopaminergic function during gambling in Parkinson's disease patients, with and without pathological gambling, following dopamine agonists. Patients with pathological gambling demonstrated greater decreases in binding potential in the ventral striatum during gambling (13.9%) than control patients (8.1%), likely reflecting greater dopaminergic release. Ventral striatal bindings at baseline during control task were also lower in patients with pathological gambling. Although prior imaging studies suggest that abnormality in dopaminergic binding and dopamine release may be markers of vulnerability to addiction, this study presents the first evidence of these phenomena in pathological gambling. The emergence of pathological gambling in a number of Parkinson's disease patients may provide a model into the pathophysiology of this disorder.</div>
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C] raclopride positron emission tomography (PET) study comparing dopaminergic function during gambling in Parkinson's disease patients, with and without pathological gambling, following dopamine agonists. Patients with pathological gambling demonstrated greater decreases in binding potential in the ventral striatum during gambling (13.9%) than control patients (8.1%), likely reflecting greater dopaminergic release. Ventral striatal bindings at baseline during control task were also lower in patients with pathological gambling. Although prior imaging studies suggest that abnormality in dopaminergic binding and dopamine release may be markers of vulnerability to addiction, this study presents the first evidence of these phenomena in pathological gambling. The emergence of pathological gambling in a number of Parkinson's disease patients may provide a model into the pathophysiology of this disorder.</s0>
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	La maladie de Parkinson au Canada (serveur d'exploration)
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La maladie de Parkinson au Canada (serveur d'exploration)

Increased striatal dopamine release in Parkinsonian patients with pathological gambling : a [11C] raclopride PET study

Increased striatal dopamine release in Parkinsonian patients with pathological gambling : a [11C] raclopride PET study

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