Effect of choline and acetate substrates on bifurcation and chaotic behavior of acetylcholine neurocycle and Alzheimer's and Parkinson's diseases
Identifieur interne : 000740 ( PascalFrancis/Curation ); précédent : 000739; suivant : 000741Effect of choline and acetate substrates on bifurcation and chaotic behavior of acetylcholine neurocycle and Alzheimer's and Parkinson's diseases
Auteurs : I. H. Mustafa [Canada] ; A. Elkamel [Canada] ; G. Ibrahim [Égypte] ; P. Chen [Canada] ; S. S. E. H. Elnashaie [Égypte]Source :
- Chemical engineering science [ 0009-2509 ] ; 2009.
Descripteurs français
- Pascal (Inist)
English descriptors
- KwdEn :
Abstract
In this work a novel two-enzyme-two-compartment model is developed in order to explore the dynamics, bifurcation, and chaotic characteristics of the acetylcholine neurocycle. The model takes into consideration the physiological events of the choline uptake into the presynaptic neuron and choline release in the postsynaptic neuron. The effects of feed choline concentrations, feed acetate concentrations as bifurcation parameters are studied. It was found that feed choline concentrations play an important role and have a direct effect on the acetylcholine neurocycle through a certain important range of parameters. The feed acetate concentrations have less effect. A detailed bifurcation analysis over a wide range of parameters is carried out in order to uncover some important features of the system, such as static bifurcation, dynamic bifurcation and chaotic behavior. These findings are related to the real phenomena occurring in the neurons, like periodic stimulation of neural cells and non-regular functioning of acetylcholine receptors. The results are compared to the results of physiological experiments and other published models. As there is strong evidence that cholinergic brain diseases like Alzheimer's disease and Parkinson's disease are related to the concentration of acetylcholine, the present findings are useful for uncovering some of the characteristics of these diseases and encouraging more well-directed physiological research coupled to useful mathematical modeling. It is concluded from the results in this paper that feed choline is more important factor than feed acetate in ACh processes.
| pA |
|
|---|
Links toward previous steps (curation, corpus...)
- to stream PascalFrancis, to step Corpus: Pour aller vers cette notice dans l'étape Curation :000552
Links to Exploration step
Pascal:09-0204928Le document en format XML
<record><TEI><teiHeader><fileDesc><titleStmt><title xml:lang="en" level="a">Effect of choline and acetate substrates on bifurcation and chaotic behavior of acetylcholine neurocycle and Alzheimer's and Parkinson's diseases</title><author><name sortKey="Mustafa, I H" sort="Mustafa, I H" uniqKey="Mustafa I" first="I. H." last="Mustafa">I. H. Mustafa</name><affiliation wicri:level="1"><inist:fA14 i1="01"><s1>Department of Chemical Engineering, University of Waterloo</s1><s2>Ontario, N2L3G1</s2><s3>CAN</s3><sZ>1 aut.</sZ><sZ>2 aut.</sZ><sZ>4 aut.</sZ></inist:fA14><country>Canada</country></affiliation></author><author><name sortKey="Elkamel, A" sort="Elkamel, A" uniqKey="Elkamel A" first="A." last="Elkamel">A. Elkamel</name><affiliation wicri:level="1"><inist:fA14 i1="01"><s1>Department of Chemical Engineering, University of Waterloo</s1><s2>Ontario, N2L3G1</s2><s3>CAN</s3><sZ>1 aut.</sZ><sZ>2 aut.</sZ><sZ>4 aut.</sZ></inist:fA14><country>Canada</country></affiliation></author><author><name sortKey="Ibrahim, G" sort="Ibrahim, G" uniqKey="Ibrahim G" first="G." last="Ibrahim">G. Ibrahim</name><affiliation wicri:level="1"><inist:fA14 i1="02"><s1>Basic Engineering Sciences Department, Faculty of Engineering, Menufia University</s1><s3>EGY</s3><sZ>3 aut.</sZ></inist:fA14><country>Égypte</country></affiliation></author><author><name sortKey="Chen, P" sort="Chen, P" uniqKey="Chen P" first="P." last="Chen">P. Chen</name><affiliation wicri:level="1"><inist:fA14 i1="01"><s1>Department of Chemical Engineering, University of Waterloo</s1><s2>Ontario, N2L3G1</s2><s3>CAN</s3><sZ>1 aut.</sZ><sZ>2 aut.</sZ><sZ>4 aut.</sZ></inist:fA14><country>Canada</country></affiliation></author><author><name sortKey="Elnashaie, S S E H" sort="Elnashaie, S S E H" uniqKey="Elnashaie S" first="S. S. E. H." last="Elnashaie">S. S. E. H. Elnashaie</name><affiliation wicri:level="1"><inist:fA14 i1="03"><s1>Dean of the College of Engineering Sciences and College of Information Technology, Sinai University, Almasaeed</s1><s2>Alarish, North Sinai</s2><s3>EGY</s3><sZ>5 aut.</sZ></inist:fA14><country>Égypte</country></affiliation></author></titleStmt><publicationStmt><idno type="wicri:source">INIST</idno><idno type="inist">09-0204928</idno><date when="2009">2009</date><idno type="stanalyst">PASCAL 09-0204928 INIST</idno><idno type="RBID">Pascal:09-0204928</idno><idno type="wicri:Area/PascalFrancis/Corpus">000552</idno><idno type="wicri:Area/PascalFrancis/Curation">000740</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en" level="a">Effect of choline and acetate substrates on bifurcation and chaotic behavior of acetylcholine neurocycle and Alzheimer's and Parkinson's diseases</title><author><name sortKey="Mustafa, I H" sort="Mustafa, I H" uniqKey="Mustafa I" first="I. H." last="Mustafa">I. H. Mustafa</name><affiliation wicri:level="1"><inist:fA14 i1="01"><s1>Department of Chemical Engineering, University of Waterloo</s1><s2>Ontario, N2L3G1</s2><s3>CAN</s3><sZ>1 aut.</sZ><sZ>2 aut.</sZ><sZ>4 aut.</sZ></inist:fA14><country>Canada</country></affiliation></author><author><name sortKey="Elkamel, A" sort="Elkamel, A" uniqKey="Elkamel A" first="A." last="Elkamel">A. Elkamel</name><affiliation wicri:level="1"><inist:fA14 i1="01"><s1>Department of Chemical Engineering, University of Waterloo</s1><s2>Ontario, N2L3G1</s2><s3>CAN</s3><sZ>1 aut.</sZ><sZ>2 aut.</sZ><sZ>4 aut.</sZ></inist:fA14><country>Canada</country></affiliation></author><author><name sortKey="Ibrahim, G" sort="Ibrahim, G" uniqKey="Ibrahim G" first="G." last="Ibrahim">G. Ibrahim</name><affiliation wicri:level="1"><inist:fA14 i1="02"><s1>Basic Engineering Sciences Department, Faculty of Engineering, Menufia University</s1><s3>EGY</s3><sZ>3 aut.</sZ></inist:fA14><country>Égypte</country></affiliation></author><author><name sortKey="Chen, P" sort="Chen, P" uniqKey="Chen P" first="P." last="Chen">P. Chen</name><affiliation wicri:level="1"><inist:fA14 i1="01"><s1>Department of Chemical Engineering, University of Waterloo</s1><s2>Ontario, N2L3G1</s2><s3>CAN</s3><sZ>1 aut.</sZ><sZ>2 aut.</sZ><sZ>4 aut.</sZ></inist:fA14><country>Canada</country></affiliation></author><author><name sortKey="Elnashaie, S S E H" sort="Elnashaie, S S E H" uniqKey="Elnashaie S" first="S. S. E. H." last="Elnashaie">S. S. E. H. Elnashaie</name><affiliation wicri:level="1"><inist:fA14 i1="03"><s1>Dean of the College of Engineering Sciences and College of Information Technology, Sinai University, Almasaeed</s1><s2>Alarish, North Sinai</s2><s3>EGY</s3><sZ>5 aut.</sZ></inist:fA14><country>Égypte</country></affiliation></author></analytic><series><title level="j" type="main">Chemical engineering science</title><title level="j" type="abbreviated">Chem. eng. sci.</title><idno type="ISSN">0009-2509</idno><imprint><date when="2009">2009</date></imprint></series></biblStruct></sourceDesc><seriesStmt><title level="j" type="main">Chemical engineering science</title><title level="j" type="abbreviated">Chem. eng. sci.</title><idno type="ISSN">0009-2509</idno></seriesStmt></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Bifurcation</term><term>Chaos</term><term>Modeling</term><term>Uptake</term></keywords><keywords scheme="Pascal" xml:lang="fr"><term>Bifurcation</term><term>Modélisation</term><term>Captation</term><term>Chaos</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">In this work a novel two-enzyme-two-compartment model is developed in order to explore the dynamics, bifurcation, and chaotic characteristics of the acetylcholine neurocycle. The model takes into consideration the physiological events of the choline uptake into the presynaptic neuron and choline release in the postsynaptic neuron. The effects of feed choline concentrations, feed acetate concentrations as bifurcation parameters are studied. It was found that feed choline concentrations play an important role and have a direct effect on the acetylcholine neurocycle through a certain important range of parameters. The feed acetate concentrations have less effect. A detailed bifurcation analysis over a wide range of parameters is carried out in order to uncover some important features of the system, such as static bifurcation, dynamic bifurcation and chaotic behavior. These findings are related to the real phenomena occurring in the neurons, like periodic stimulation of neural cells and non-regular functioning of acetylcholine receptors. The results are compared to the results of physiological experiments and other published models. As there is strong evidence that cholinergic brain diseases like Alzheimer's disease and Parkinson's disease are related to the concentration of acetylcholine, the present findings are useful for uncovering some of the characteristics of these diseases and encouraging more well-directed physiological research coupled to useful mathematical modeling. It is concluded from the results in this paper that feed choline is more important factor than feed acetate in ACh processes.</div></front></TEI><inist><standard h6="B"><pA><fA01 i1="01" i2="1"><s0>0009-2509</s0></fA01><fA02 i1="01"><s0>CESCAC</s0></fA02><fA03 i2="1"><s0>Chem. eng. sci.</s0></fA03><fA05><s2>64</s2></fA05><fA06><s2>9</s2></fA06><fA08 i1="01" i2="1" l="ENG"><s1>Effect of choline and acetate substrates on bifurcation and chaotic behavior of acetylcholine neurocycle and Alzheimer's and Parkinson's diseases</s1></fA08><fA11 i1="01" i2="1"><s1>MUSTAFA (I. H.)</s1></fA11><fA11 i1="02" i2="1"><s1>ELKAMEL (A.)</s1></fA11><fA11 i1="03" i2="1"><s1>IBRAHIM (G.)</s1></fA11><fA11 i1="04" i2="1"><s1>CHEN (P.)</s1></fA11><fA11 i1="05" i2="1"><s1>ELNASHAIE (S. S. E. H.)</s1></fA11><fA14 i1="01"><s1>Department of Chemical Engineering, University of Waterloo</s1><s2>Ontario, N2L3G1</s2><s3>CAN</s3><sZ>1 aut.</sZ><sZ>2 aut.</sZ><sZ>4 aut.</sZ></fA14><fA14 i1="02"><s1>Basic Engineering Sciences Department, Faculty of Engineering, Menufia University</s1><s3>EGY</s3><sZ>3 aut.</sZ></fA14><fA14 i1="03"><s1>Dean of the College of Engineering Sciences and College of Information Technology, Sinai University, Almasaeed</s1><s2>Alarish, North Sinai</s2><s3>EGY</s3><sZ>5 aut.</sZ></fA14><fA20><s1>2096-2112</s1></fA20><fA21><s1>2009</s1></fA21><fA23 i1="01"><s0>ENG</s0></fA23><fA43 i1="01"><s1>INIST</s1><s2>7538</s2><s5>354000186024260210</s5></fA43><fA44><s0>0000</s0><s1>© 2009 INIST-CNRS. All rights reserved.</s1></fA44><fA45><s0>1 p.1/2</s0></fA45><fA47 i1="01" i2="1"><s0>09-0204928</s0></fA47><fA60><s1>P</s1></fA60><fA61><s0>A</s0></fA61><fA64 i1="01" i2="1"><s0>Chemical engineering science</s0></fA64><fA66 i1="01"><s0>GBR</s0></fA66><fC01 i1="01" l="ENG"><s0>In this work a novel two-enzyme-two-compartment model is developed in order to explore the dynamics, bifurcation, and chaotic characteristics of the acetylcholine neurocycle. The model takes into consideration the physiological events of the choline uptake into the presynaptic neuron and choline release in the postsynaptic neuron. The effects of feed choline concentrations, feed acetate concentrations as bifurcation parameters are studied. It was found that feed choline concentrations play an important role and have a direct effect on the acetylcholine neurocycle through a certain important range of parameters. The feed acetate concentrations have less effect. A detailed bifurcation analysis over a wide range of parameters is carried out in order to uncover some important features of the system, such as static bifurcation, dynamic bifurcation and chaotic behavior. These findings are related to the real phenomena occurring in the neurons, like periodic stimulation of neural cells and non-regular functioning of acetylcholine receptors. The results are compared to the results of physiological experiments and other published models. As there is strong evidence that cholinergic brain diseases like Alzheimer's disease and Parkinson's disease are related to the concentration of acetylcholine, the present findings are useful for uncovering some of the characteristics of these diseases and encouraging more well-directed physiological research coupled to useful mathematical modeling. It is concluded from the results in this paper that feed choline is more important factor than feed acetate in ACh processes.</s0></fC01><fC02 i1="01" i2="X"><s0>001D07</s0></fC02><fC03 i1="01" i2="X" l="FRE"><s0>Bifurcation</s0><s5>01</s5></fC03><fC03 i1="01" i2="X" l="ENG"><s0>Bifurcation</s0><s5>01</s5></fC03><fC03 i1="01" i2="X" l="SPA"><s0>Bifurcación</s0><s5>01</s5></fC03><fC03 i1="02" i2="X" l="FRE"><s0>Modélisation</s0><s5>02</s5></fC03><fC03 i1="02" i2="X" l="ENG"><s0>Modeling</s0><s5>02</s5></fC03><fC03 i1="02" i2="X" l="SPA"><s0>Modelización</s0><s5>02</s5></fC03><fC03 i1="03" i2="X" l="FRE"><s0>Captation</s0><s5>03</s5></fC03><fC03 i1="03" i2="X" l="ENG"><s0>Uptake</s0><s5>03</s5></fC03><fC03 i1="03" i2="X" l="SPA"><s0>Captación</s0><s5>03</s5></fC03><fC03 i1="04" i2="X" l="FRE"><s0>Chaos</s0><s5>04</s5></fC03><fC03 i1="04" i2="X" l="ENG"><s0>Chaos</s0><s5>04</s5></fC03><fC03 i1="04" i2="X" l="SPA"><s0>Caos</s0><s5>04</s5></fC03><fN21><s1>152</s1></fN21><fN44 i1="01"><s1>OTO</s1></fN44><fN82><s1>OTO</s1></fN82></pA></standard></inist></record>Pour manipuler ce document sous Unix (Dilib)
EXPLOR_STEP=$WICRI_ROOT/Wicri/Canada/explor/ParkinsonCanadaV1/Data/PascalFrancis/Curation
HfdSelect -h $EXPLOR_STEP/biblio.hfd -nk 000740 | SxmlIndent | more
Ou
HfdSelect -h $EXPLOR_AREA/Data/PascalFrancis/Curation/biblio.hfd -nk 000740 | SxmlIndent | more
Pour mettre un lien sur cette page dans le réseau Wicri
{{Explor lien
|wiki= Wicri/Canada
|area= ParkinsonCanadaV1
|flux= PascalFrancis
|étape= Curation
|type= RBID
|clé= Pascal:09-0204928
|texte= Effect of choline and acetate substrates on bifurcation and chaotic behavior of acetylcholine neurocycle and Alzheimer's and Parkinson's diseases
}}
| This area was generated with Dilib version V0.6.29. |  |