ParkinsonCanadaV1, PascalFrancis, Curation, bibRecord, 000675

NEUROTOXIC LESIONS AT THE VENTRAL MESOPONTINE JUNCTION CHANGE SLEEP TIME AND MUSCLE ACTIVITY DURING SLEEP : AN ANIMAL MODEL OF MOTOR DISORDERS IN SLEEP

Identifieur interne : 000675 ( PascalFrancis/Curation ); précédent : 000674; suivant : 000676

NEUROTOXIC LESIONS AT THE VENTRAL MESOPONTINE JUNCTION CHANGE SLEEP TIME AND MUSCLE ACTIVITY DURING SLEEP : AN ANIMAL MODEL OF MOTOR DISORDERS IN SLEEP

Auteurs : Y.-Y. Lai [États-Unis] ; K.-C. Hsieh [États-Unis] ; D. Nguyen [États-Unis] ; J. Peever [Canada] ; J. M. Siegel [États-Unis]

Source :

Neuroscience [ 0306-4522 ] ; 2008.

RBID : Pascal:08-0364351

Descripteurs français

Pascal (Inist)
- Lésion, Sommeil paradoxal, Muscle, Modèle animal, Membre inférieur, Comportement, Locus niger, Maladie de Parkinson.

English descriptors

KwdEn :
- Animal model, Behavior, Lesion, Locus niger, Lower limb, Muscle, Parkinson disease, Rapid eye movement sleep.

Abstract

There is no adequate animal model of restless legs syndrome (RLS) and periodic leg movements disorder (PLMD), disorders affecting 10% of the population. Similarly, there is no model of rapid eye movement (REM) sleep behavior disorder (RBD) that explains its symptoms and its link to Parkinsonism. We previously reported that the motor inhibitory system in the brainstem extends from the medulla to the ventral mesopontine junction (VMPJ). We now examine the effects of damage to the VMPJ in the cat. Based on the lesion sites and the changes in sleep pattern and behavior, we saw three distinct syndromes resulting from such lesions; the rostrolateral, rostromedial and caudalVMPJ syndromes. The change in sleep pattern was dependent on the lesion site, but was not significantly correlated with the number of dopaminergic neurons lost. An increase in wakefulness and a decrease in slow wave sleep (SWS) and REM sleep were seen in the rostrolateral VMPJ-lesioned animals. In contrast, the sleep pattern was not significantly changed in the rostromedial and caudal VMPJ-lesioned animals. All three groups of animals showed a significant increase in periodic and isolated leg movements in SWS and increased tonic muscle activity in REM sleep. Beyond these common symptoms, an increase in phasic motor activity in REM sleep, resembling that seen in human RBD, was found in the caudal VMPJ-lesioned animals. In contrast, the increase in motor activity in SWS in rostral VMPJ-lesioned animals is similar to that seen in human RLS/PLMD patients. The proximity of the VMPJ region to the substantia nigra suggests that the link between RLS/PLMD and Parkinsonism, as well as the progression from RBD to Parkinsonism may be mediated by the spread of damage from the regions identified here into the substantia nigra.

A01	`01`	`1`		`@0 0306-4522`
A02	`01`			`@0 NRSCDN`
A03		`1`		`@0 Neuroscience`
A05				`@2 154`
A06				`@2 2`
A08	`01`	`1`	`ENG`	`@1 NEUROTOXIC LESIONS AT THE VENTRAL MESOPONTINE JUNCTION CHANGE SLEEP TIME AND MUSCLE ACTIVITY DURING SLEEP : AN ANIMAL MODEL OF MOTOR DISORDERS IN SLEEP`
A11	`01`	`1`		`@1 LAI (Y.-Y.)`
A11	`02`	`1`		`@1 HSIEH (K.-C.)`
A11	`03`	`1`		`@1 NGUYEN (D.)`
A11	`04`	`1`		`@1 PEEVER (J.)`
A11	`05`	`1`		`@1 SIEGEL (J. M.)`
A14	`01`			`@1 Department of Psychiatry and Biobehavioral Science, Neurobiology Research (151A3), David Geffen School of Medicine, UCLA and Veterans Administration Greater Los Angeles Healthcare System Sepulveda, 16111 Plummer Street @2 North Hills, CA 91343 @3 USA @Z 1 aut. @Z 2 aut. @Z 3 aut. @Z 5 aut.`
A14	`02`			`@1 Systems Neurobiology Laboratory, Departments of Physiology and Cell and Systems Biology, University of Toronto, 25 Harbord Street @2 Toronto, ON, M5S 3G5 @3 CAN @Z 4 aut.`
A20				`@1 431-443`
A21				`@1 2008`
A23	`01`			`@0 ENG`
A43	`01`			`@1 INIST @2 17194 @5 354000196024820040`
A44				`@0 0000 @1 © 2008 INIST-CNRS. All rights reserved.`
A45				`@0 2 p.1/4`
A47	`01`	`1`		`@0 08-0364351`
A60				`@1 P`
A61				`@0 A`
A64	`01`	`1`		`@0 Neuroscience`
A66	`01`			`@0 GBR`
C01	`01`		`ENG`	@0 There is no adequate animal model of restless legs syndrome (RLS) and periodic leg movements disorder (PLMD), disorders affecting 10% of the population. Similarly, there is no model of rapid eye movement (REM) sleep behavior disorder (RBD) that explains its symptoms and its link to Parkinsonism. We previously reported that the motor inhibitory system in the brainstem extends from the medulla to the ventral mesopontine junction (VMPJ). We now examine the effects of damage to the VMPJ in the cat. Based on the lesion sites and the changes in sleep pattern and behavior, we saw three distinct syndromes resulting from such lesions; the rostrolateral, rostromedial and caudalVMPJ syndromes. The change in sleep pattern was dependent on the lesion site, but was not significantly correlated with the number of dopaminergic neurons lost. An increase in wakefulness and a decrease in slow wave sleep (SWS) and REM sleep were seen in the rostrolateral VMPJ-lesioned animals. In contrast, the sleep pattern was not significantly changed in the rostromedial and caudal VMPJ-lesioned animals. All three groups of animals showed a significant increase in periodic and isolated leg movements in SWS and increased tonic muscle activity in REM sleep. Beyond these common symptoms, an increase in phasic motor activity in REM sleep, resembling that seen in human RBD, was found in the caudal VMPJ-lesioned animals. In contrast, the increase in motor activity in SWS in rostral VMPJ-lesioned animals is similar to that seen in human RLS/PLMD patients. The proximity of the VMPJ region to the substantia nigra suggests that the link between RLS/PLMD and Parkinsonism, as well as the progression from RBD to Parkinsonism may be mediated by the spread of damage from the regions identified here into the substantia nigra.
C02	`01`	`X`		`@0 002A25K`
C02	`02`	`X`		`@0 002B17G`
C03	`01`	`X`	`FRE`	`@0 Lésion @5 01`
C03	`01`	`X`	`ENG`	`@0 Lesion @5 01`
C03	`01`	`X`	`SPA`	`@0 Lesión @5 01`
C03	`02`	`X`	`FRE`	`@0 Sommeil paradoxal @5 02`
C03	`02`	`X`	`ENG`	`@0 Rapid eye movement sleep @5 02`
C03	`02`	`X`	`SPA`	`@0 Sueño paradojal @5 02`
C03	`03`	`X`	`FRE`	`@0 Muscle @5 03`
C03	`03`	`X`	`ENG`	`@0 Muscle @5 03`
C03	`03`	`X`	`SPA`	`@0 Músculo @5 03`
C03	`04`	`X`	`FRE`	`@0 Modèle animal @5 04`
C03	`04`	`X`	`ENG`	`@0 Animal model @5 04`
C03	`04`	`X`	`SPA`	`@0 Modelo animal @5 04`
C03	`05`	`X`	`FRE`	`@0 Membre inférieur @5 05`
C03	`05`	`X`	`ENG`	`@0 Lower limb @5 05`
C03	`05`	`X`	`SPA`	`@0 Miembro inferior @5 05`
C03	`06`	`X`	`FRE`	`@0 Comportement @5 06`
C03	`06`	`X`	`ENG`	`@0 Behavior @5 06`
C03	`06`	`X`	`SPA`	`@0 Conducta @5 06`
C03	`07`	`X`	`FRE`	`@0 Locus niger @5 07`
C03	`07`	`X`	`ENG`	`@0 Locus niger @5 07`
C03	`07`	`X`	`SPA`	`@0 Locus níger @5 07`
C03	`08`	`X`	`FRE`	`@0 Maladie de Parkinson @2 NM @5 09`
C03	`08`	`X`	`ENG`	`@0 Parkinson disease @2 NM @5 09`
C03	`08`	`X`	`SPA`	`@0 Parkinson enfermedad @2 NM @5 09`
C07	`01`	`X`	`FRE`	`@0 Maladie dégénérative @5 20`
C07	`01`	`X`	`ENG`	`@0 Degenerative disease @5 20`
C07	`01`	`X`	`SPA`	`@0 Enfermedad degenerativa @5 20`
C07	`02`	`X`	`FRE`	`@0 Pathologie du système nerveux @5 21`
C07	`02`	`X`	`ENG`	`@0 Nervous system diseases @5 21`
C07	`02`	`X`	`SPA`	`@0 Sistema nervioso patología @5 21`
C07	`03`	`X`	`FRE`	`@0 Pathologie de l'encéphale @5 22`
C07	`03`	`X`	`ENG`	`@0 Cerebral disorder @5 22`
C07	`03`	`X`	`SPA`	`@0 Encéfalo patología @5 22`
C07	`04`	`X`	`FRE`	`@0 Syndrome extrapyramidal @5 23`
C07	`04`	`X`	`ENG`	`@0 Extrapyramidal syndrome @5 23`
C07	`04`	`X`	`SPA`	`@0 Extrapiramidal síndrome @5 23`
C07	`05`	`X`	`FRE`	`@0 Pathologie du système nerveux central @5 24`
C07	`05`	`X`	`ENG`	`@0 Central nervous system disease @5 24`
C07	`05`	`X`	`SPA`	`@0 Sistema nervosio central patología @5 24`
C07	`06`	`X`	`FRE`	`@0 Encéphale @5 25`
C07	`06`	`X`	`ENG`	`@0 Encephalon @5 25`
C07	`06`	`X`	`SPA`	`@0 Encéfalo @5 25`
C07	`07`	`X`	`FRE`	`@0 Système nerveux central @5 26`
C07	`07`	`X`	`ENG`	`@0 Central nervous system @5 26`
C07	`07`	`X`	`SPA`	`@0 Sistema nervioso central @5 26`
N21				`@1 231`
N44	`01`			`@1 OTO`
N82				`@1 OTO`

Links toward previous steps (curation, corpus...)

to stream PascalFrancis, to step Corpus: Pour aller vers cette notice dans l'étape Curation :000635

Links to Exploration step

Pascal:08-0364351

Le document en format XML

<record><TEI><teiHeader><fileDesc><titleStmt><title xml:lang="en" level="a">NEUROTOXIC LESIONS AT THE VENTRAL MESOPONTINE JUNCTION CHANGE SLEEP TIME AND MUSCLE ACTIVITY DURING SLEEP : AN ANIMAL MODEL OF MOTOR DISORDERS IN SLEEP</title>
<author><name sortKey="Lai, Y Y" sort="Lai, Y Y" uniqKey="Lai Y" first="Y.-Y." last="Lai">Y.-Y. Lai</name>
<affiliation wicri:level="1"><inist:fA14 i1="01"><s1>Department of Psychiatry and Biobehavioral Science, Neurobiology Research (151A3), David Geffen School of Medicine, UCLA and Veterans Administration Greater Los Angeles Healthcare System Sepulveda, 16111 Plummer Street</s1>
<s2>North Hills, CA 91343</s2>
<s3>USA</s3>
<sZ>1 aut.</sZ>
<sZ>2 aut.</sZ>
<sZ>3 aut.</sZ>
<sZ>5 aut.</sZ>
</inist:fA14>
<country>États-Unis</country>
</affiliation>
</author>
<author><name sortKey="Hsieh, K C" sort="Hsieh, K C" uniqKey="Hsieh K" first="K.-C." last="Hsieh">K.-C. Hsieh</name>
<affiliation wicri:level="1"><inist:fA14 i1="01"><s1>Department of Psychiatry and Biobehavioral Science, Neurobiology Research (151A3), David Geffen School of Medicine, UCLA and Veterans Administration Greater Los Angeles Healthcare System Sepulveda, 16111 Plummer Street</s1>
<s2>North Hills, CA 91343</s2>
<s3>USA</s3>
<sZ>1 aut.</sZ>
<sZ>2 aut.</sZ>
<sZ>3 aut.</sZ>
<sZ>5 aut.</sZ>
</inist:fA14>
<country>États-Unis</country>
</affiliation>
</author>
<author><name sortKey="Nguyen, D" sort="Nguyen, D" uniqKey="Nguyen D" first="D." last="Nguyen">D. Nguyen</name>
<affiliation wicri:level="1"><inist:fA14 i1="01"><s1>Department of Psychiatry and Biobehavioral Science, Neurobiology Research (151A3), David Geffen School of Medicine, UCLA and Veterans Administration Greater Los Angeles Healthcare System Sepulveda, 16111 Plummer Street</s1>
<s2>North Hills, CA 91343</s2>
<s3>USA</s3>
<sZ>1 aut.</sZ>
<sZ>2 aut.</sZ>
<sZ>3 aut.</sZ>
<sZ>5 aut.</sZ>
</inist:fA14>
<country>États-Unis</country>
</affiliation>
</author>
<author><name sortKey="Peever, J" sort="Peever, J" uniqKey="Peever J" first="J." last="Peever">J. Peever</name>
<affiliation wicri:level="1"><inist:fA14 i1="02"><s1>Systems Neurobiology Laboratory, Departments of Physiology and Cell and Systems Biology, University of Toronto, 25 Harbord Street</s1>
<s2>Toronto, ON, M5S 3G5</s2>
<s3>CAN</s3>
<sZ>4 aut.</sZ>
</inist:fA14>
<country>Canada</country>
</affiliation>
</author>
<author><name sortKey="Siegel, J M" sort="Siegel, J M" uniqKey="Siegel J" first="J. M." last="Siegel">J. M. Siegel</name>
<affiliation wicri:level="1"><inist:fA14 i1="01"><s1>Department of Psychiatry and Biobehavioral Science, Neurobiology Research (151A3), David Geffen School of Medicine, UCLA and Veterans Administration Greater Los Angeles Healthcare System Sepulveda, 16111 Plummer Street</s1>
<s2>North Hills, CA 91343</s2>
<s3>USA</s3>
<sZ>1 aut.</sZ>
<sZ>2 aut.</sZ>
<sZ>3 aut.</sZ>
<sZ>5 aut.</sZ>
</inist:fA14>
<country>États-Unis</country>
</affiliation>
</author>
</titleStmt>
<publicationStmt><idno type="wicri:source">INIST</idno>
<idno type="inist">08-0364351</idno>
<date when="2008">2008</date>
<idno type="stanalyst">PASCAL 08-0364351 INIST</idno>
<idno type="RBID">Pascal:08-0364351</idno>
<idno type="wicri:Area/PascalFrancis/Corpus">000635</idno>
<idno type="wicri:Area/PascalFrancis/Curation">000675</idno>
</publicationStmt>
<sourceDesc><biblStruct><analytic><title xml:lang="en" level="a">NEUROTOXIC LESIONS AT THE VENTRAL MESOPONTINE JUNCTION CHANGE SLEEP TIME AND MUSCLE ACTIVITY DURING SLEEP : AN ANIMAL MODEL OF MOTOR DISORDERS IN SLEEP</title>
<author><name sortKey="Lai, Y Y" sort="Lai, Y Y" uniqKey="Lai Y" first="Y.-Y." last="Lai">Y.-Y. Lai</name>
<affiliation wicri:level="1"><inist:fA14 i1="01"><s1>Department of Psychiatry and Biobehavioral Science, Neurobiology Research (151A3), David Geffen School of Medicine, UCLA and Veterans Administration Greater Los Angeles Healthcare System Sepulveda, 16111 Plummer Street</s1>
<s2>North Hills, CA 91343</s2>
<s3>USA</s3>
<sZ>1 aut.</sZ>
<sZ>2 aut.</sZ>
<sZ>3 aut.</sZ>
<sZ>5 aut.</sZ>
</inist:fA14>
<country>États-Unis</country>
</affiliation>
</author>
<author><name sortKey="Hsieh, K C" sort="Hsieh, K C" uniqKey="Hsieh K" first="K.-C." last="Hsieh">K.-C. Hsieh</name>
<affiliation wicri:level="1"><inist:fA14 i1="01"><s1>Department of Psychiatry and Biobehavioral Science, Neurobiology Research (151A3), David Geffen School of Medicine, UCLA and Veterans Administration Greater Los Angeles Healthcare System Sepulveda, 16111 Plummer Street</s1>
<s2>North Hills, CA 91343</s2>
<s3>USA</s3>
<sZ>1 aut.</sZ>
<sZ>2 aut.</sZ>
<sZ>3 aut.</sZ>
<sZ>5 aut.</sZ>
</inist:fA14>
<country>États-Unis</country>
</affiliation>
</author>
<author><name sortKey="Nguyen, D" sort="Nguyen, D" uniqKey="Nguyen D" first="D." last="Nguyen">D. Nguyen</name>
<affiliation wicri:level="1"><inist:fA14 i1="01"><s1>Department of Psychiatry and Biobehavioral Science, Neurobiology Research (151A3), David Geffen School of Medicine, UCLA and Veterans Administration Greater Los Angeles Healthcare System Sepulveda, 16111 Plummer Street</s1>
<s2>North Hills, CA 91343</s2>
<s3>USA</s3>
<sZ>1 aut.</sZ>
<sZ>2 aut.</sZ>
<sZ>3 aut.</sZ>
<sZ>5 aut.</sZ>
</inist:fA14>
<country>États-Unis</country>
</affiliation>
</author>
<author><name sortKey="Peever, J" sort="Peever, J" uniqKey="Peever J" first="J." last="Peever">J. Peever</name>
<affiliation wicri:level="1"><inist:fA14 i1="02"><s1>Systems Neurobiology Laboratory, Departments of Physiology and Cell and Systems Biology, University of Toronto, 25 Harbord Street</s1>
<s2>Toronto, ON, M5S 3G5</s2>
<s3>CAN</s3>
<sZ>4 aut.</sZ>
</inist:fA14>
<country>Canada</country>
</affiliation>
</author>
<author><name sortKey="Siegel, J M" sort="Siegel, J M" uniqKey="Siegel J" first="J. M." last="Siegel">J. M. Siegel</name>
<affiliation wicri:level="1"><inist:fA14 i1="01"><s1>Department of Psychiatry and Biobehavioral Science, Neurobiology Research (151A3), David Geffen School of Medicine, UCLA and Veterans Administration Greater Los Angeles Healthcare System Sepulveda, 16111 Plummer Street</s1>
<s2>North Hills, CA 91343</s2>
<s3>USA</s3>
<sZ>1 aut.</sZ>
<sZ>2 aut.</sZ>
<sZ>3 aut.</sZ>
<sZ>5 aut.</sZ>
</inist:fA14>
<country>États-Unis</country>
</affiliation>
</author>
</analytic>
<series><title level="j" type="main">Neuroscience</title>
<title level="j" type="abbreviated">Neuroscience</title>
<idno type="ISSN">0306-4522</idno>
<imprint><date when="2008">2008</date>
</imprint>
</series>
</biblStruct>
</sourceDesc>
<seriesStmt><title level="j" type="main">Neuroscience</title>
<title level="j" type="abbreviated">Neuroscience</title>
<idno type="ISSN">0306-4522</idno>
</seriesStmt>
</fileDesc>
<profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Animal model</term>
<term>Behavior</term>
<term>Lesion</term>
<term>Locus niger</term>
<term>Lower limb</term>
<term>Muscle</term>
<term>Parkinson disease</term>
<term>Rapid eye movement sleep</term>
</keywords>
<keywords scheme="Pascal" xml:lang="fr"><term>Lésion</term>
<term>Sommeil paradoxal</term>
<term>Muscle</term>
<term>Modèle animal</term>
<term>Membre inférieur</term>
<term>Comportement</term>
<term>Locus niger</term>
<term>Maladie de Parkinson</term>
</keywords>
</textClass>
</profileDesc>
</teiHeader>
<front><div type="abstract" xml:lang="en">There is no adequate animal model of restless legs syndrome (RLS) and periodic leg movements disorder (PLMD), disorders affecting 10% of the population. Similarly, there is no model of rapid eye movement (REM) sleep behavior disorder (RBD) that explains its symptoms and its link to Parkinsonism. We previously reported that the motor inhibitory system in the brainstem extends from the medulla to the ventral mesopontine junction (VMPJ). We now examine the effects of damage to the VMPJ in the cat. Based on the lesion sites and the changes in sleep pattern and behavior, we saw three distinct syndromes resulting from such lesions; the rostrolateral, rostromedial and caudalVMPJ syndromes. The change in sleep pattern was dependent on the lesion site, but was not significantly correlated with the number of dopaminergic neurons lost. An increase in wakefulness and a decrease in slow wave sleep (SWS) and REM sleep were seen in the rostrolateral VMPJ-lesioned animals. In contrast, the sleep pattern was not significantly changed in the rostromedial and caudal VMPJ-lesioned animals. All three groups of animals showed a significant increase in periodic and isolated leg movements in SWS and increased tonic muscle activity in REM sleep. Beyond these common symptoms, an increase in phasic motor activity in REM sleep, resembling that seen in human RBD, was found in the caudal VMPJ-lesioned animals. In contrast, the increase in motor activity in SWS in rostral VMPJ-lesioned animals is similar to that seen in human RLS/PLMD patients. The proximity of the VMPJ region to the substantia nigra suggests that the link between RLS/PLMD and Parkinsonism, as well as the progression from RBD to Parkinsonism may be mediated by the spread of damage from the regions identified here into the substantia nigra.</div>
</front>
</TEI>
<inist><standard h6="B"><pA><fA01 i1="01" i2="1"><s0>0306-4522</s0>
</fA01>
<fA02 i1="01"><s0>NRSCDN</s0>
</fA02>
<fA03 i2="1"><s0>Neuroscience</s0>
</fA03>
<fA05><s2>154</s2>
</fA05>
<fA06><s2>2</s2>
</fA06>
<fA08 i1="01" i2="1" l="ENG"><s1>NEUROTOXIC LESIONS AT THE VENTRAL MESOPONTINE JUNCTION CHANGE SLEEP TIME AND MUSCLE ACTIVITY DURING SLEEP : AN ANIMAL MODEL OF MOTOR DISORDERS IN SLEEP</s1>
</fA08>
<fA11 i1="01" i2="1"><s1>LAI (Y.-Y.)</s1>
</fA11>
<fA11 i1="02" i2="1"><s1>HSIEH (K.-C.)</s1>
</fA11>
<fA11 i1="03" i2="1"><s1>NGUYEN (D.)</s1>
</fA11>
<fA11 i1="04" i2="1"><s1>PEEVER (J.)</s1>
</fA11>
<fA11 i1="05" i2="1"><s1>SIEGEL (J. M.)</s1>
</fA11>
<fA14 i1="01"><s1>Department of Psychiatry and Biobehavioral Science, Neurobiology Research (151A3), David Geffen School of Medicine, UCLA and Veterans Administration Greater Los Angeles Healthcare System Sepulveda, 16111 Plummer Street</s1>
<s2>North Hills, CA 91343</s2>
<s3>USA</s3>
<sZ>1 aut.</sZ>
<sZ>2 aut.</sZ>
<sZ>3 aut.</sZ>
<sZ>5 aut.</sZ>
</fA14>
<fA14 i1="02"><s1>Systems Neurobiology Laboratory, Departments of Physiology and Cell and Systems Biology, University of Toronto, 25 Harbord Street</s1>
<s2>Toronto, ON, M5S 3G5</s2>
<s3>CAN</s3>
<sZ>4 aut.</sZ>
</fA14>
<fA20><s1>431-443</s1>
</fA20>
<fA21><s1>2008</s1>
</fA21>
<fA23 i1="01"><s0>ENG</s0>
</fA23>
<fA43 i1="01"><s1>INIST</s1>
<s2>17194</s2>
<s5>354000196024820040</s5>
</fA43>
<fA44><s0>0000</s0>
<s1>© 2008 INIST-CNRS. All rights reserved.</s1>
</fA44>
<fA45><s0>2 p.1/4</s0>
</fA45>
<fA47 i1="01" i2="1"><s0>08-0364351</s0>
</fA47>
<fA60><s1>P</s1>
</fA60>
<fA61><s0>A</s0>
</fA61>
<fA64 i1="01" i2="1"><s0>Neuroscience</s0>
</fA64>
<fA66 i1="01"><s0>GBR</s0>
</fA66>
<fC01 i1="01" l="ENG"><s0>There is no adequate animal model of restless legs syndrome (RLS) and periodic leg movements disorder (PLMD), disorders affecting 10% of the population. Similarly, there is no model of rapid eye movement (REM) sleep behavior disorder (RBD) that explains its symptoms and its link to Parkinsonism. We previously reported that the motor inhibitory system in the brainstem extends from the medulla to the ventral mesopontine junction (VMPJ). We now examine the effects of damage to the VMPJ in the cat. Based on the lesion sites and the changes in sleep pattern and behavior, we saw three distinct syndromes resulting from such lesions; the rostrolateral, rostromedial and caudalVMPJ syndromes. The change in sleep pattern was dependent on the lesion site, but was not significantly correlated with the number of dopaminergic neurons lost. An increase in wakefulness and a decrease in slow wave sleep (SWS) and REM sleep were seen in the rostrolateral VMPJ-lesioned animals. In contrast, the sleep pattern was not significantly changed in the rostromedial and caudal VMPJ-lesioned animals. All three groups of animals showed a significant increase in periodic and isolated leg movements in SWS and increased tonic muscle activity in REM sleep. Beyond these common symptoms, an increase in phasic motor activity in REM sleep, resembling that seen in human RBD, was found in the caudal VMPJ-lesioned animals. In contrast, the increase in motor activity in SWS in rostral VMPJ-lesioned animals is similar to that seen in human RLS/PLMD patients. The proximity of the VMPJ region to the substantia nigra suggests that the link between RLS/PLMD and Parkinsonism, as well as the progression from RBD to Parkinsonism may be mediated by the spread of damage from the regions identified here into the substantia nigra.</s0>
</fC01>
<fC02 i1="01" i2="X"><s0>002A25K</s0>
</fC02>
<fC02 i1="02" i2="X"><s0>002B17G</s0>
</fC02>
<fC03 i1="01" i2="X" l="FRE"><s0>Lésion</s0>
<s5>01</s5>
</fC03>
<fC03 i1="01" i2="X" l="ENG"><s0>Lesion</s0>
<s5>01</s5>
</fC03>
<fC03 i1="01" i2="X" l="SPA"><s0>Lesión</s0>
<s5>01</s5>
</fC03>
<fC03 i1="02" i2="X" l="FRE"><s0>Sommeil paradoxal</s0>
<s5>02</s5>
</fC03>
<fC03 i1="02" i2="X" l="ENG"><s0>Rapid eye movement sleep</s0>
<s5>02</s5>
</fC03>
<fC03 i1="02" i2="X" l="SPA"><s0>Sueño paradojal</s0>
<s5>02</s5>
</fC03>
<fC03 i1="03" i2="X" l="FRE"><s0>Muscle</s0>
<s5>03</s5>
</fC03>
<fC03 i1="03" i2="X" l="ENG"><s0>Muscle</s0>
<s5>03</s5>
</fC03>
<fC03 i1="03" i2="X" l="SPA"><s0>Músculo</s0>
<s5>03</s5>
</fC03>
<fC03 i1="04" i2="X" l="FRE"><s0>Modèle animal</s0>
<s5>04</s5>
</fC03>
<fC03 i1="04" i2="X" l="ENG"><s0>Animal model</s0>
<s5>04</s5>
</fC03>
<fC03 i1="04" i2="X" l="SPA"><s0>Modelo animal</s0>
<s5>04</s5>
</fC03>
<fC03 i1="05" i2="X" l="FRE"><s0>Membre inférieur</s0>
<s5>05</s5>
</fC03>
<fC03 i1="05" i2="X" l="ENG"><s0>Lower limb</s0>
<s5>05</s5>
</fC03>
<fC03 i1="05" i2="X" l="SPA"><s0>Miembro inferior</s0>
<s5>05</s5>
</fC03>
<fC03 i1="06" i2="X" l="FRE"><s0>Comportement</s0>
<s5>06</s5>
</fC03>
<fC03 i1="06" i2="X" l="ENG"><s0>Behavior</s0>
<s5>06</s5>
</fC03>
<fC03 i1="06" i2="X" l="SPA"><s0>Conducta</s0>
<s5>06</s5>
</fC03>
<fC03 i1="07" i2="X" l="FRE"><s0>Locus niger</s0>
<s5>07</s5>
</fC03>
<fC03 i1="07" i2="X" l="ENG"><s0>Locus niger</s0>
<s5>07</s5>
</fC03>
<fC03 i1="07" i2="X" l="SPA"><s0>Locus níger</s0>
<s5>07</s5>
</fC03>
<fC03 i1="08" i2="X" l="FRE"><s0>Maladie de Parkinson</s0>
<s2>NM</s2>
<s5>09</s5>
</fC03>
<fC03 i1="08" i2="X" l="ENG"><s0>Parkinson disease</s0>
<s2>NM</s2>
<s5>09</s5>
</fC03>
<fC03 i1="08" i2="X" l="SPA"><s0>Parkinson enfermedad</s0>
<s2>NM</s2>
<s5>09</s5>
</fC03>
<fC07 i1="01" i2="X" l="FRE"><s0>Maladie dégénérative</s0>
<s5>20</s5>
</fC07>
<fC07 i1="01" i2="X" l="ENG"><s0>Degenerative disease</s0>
<s5>20</s5>
</fC07>
<fC07 i1="01" i2="X" l="SPA"><s0>Enfermedad degenerativa</s0>
<s5>20</s5>
</fC07>
<fC07 i1="02" i2="X" l="FRE"><s0>Pathologie du   système nerveux</s0>
<s5>21</s5>
</fC07>
<fC07 i1="02" i2="X" l="ENG"><s0>Nervous system diseases</s0>
<s5>21</s5>
</fC07>
<fC07 i1="02" i2="X" l="SPA"><s0>Sistema nervioso patología</s0>
<s5>21</s5>
</fC07>
<fC07 i1="03" i2="X" l="FRE"><s0>Pathologie de l'encéphale</s0>
<s5>22</s5>
</fC07>
<fC07 i1="03" i2="X" l="ENG"><s0>Cerebral disorder</s0>
<s5>22</s5>
</fC07>
<fC07 i1="03" i2="X" l="SPA"><s0>Encéfalo patología</s0>
<s5>22</s5>
</fC07>
<fC07 i1="04" i2="X" l="FRE"><s0>Syndrome extrapyramidal</s0>
<s5>23</s5>
</fC07>
<fC07 i1="04" i2="X" l="ENG"><s0>Extrapyramidal syndrome</s0>
<s5>23</s5>
</fC07>
<fC07 i1="04" i2="X" l="SPA"><s0>Extrapiramidal síndrome</s0>
<s5>23</s5>
</fC07>
<fC07 i1="05" i2="X" l="FRE"><s0>Pathologie du   système nerveux central</s0>
<s5>24</s5>
</fC07>
<fC07 i1="05" i2="X" l="ENG"><s0>Central nervous system disease</s0>
<s5>24</s5>
</fC07>
<fC07 i1="05" i2="X" l="SPA"><s0>Sistema nervosio central patología</s0>
<s5>24</s5>
</fC07>
<fC07 i1="06" i2="X" l="FRE"><s0>Encéphale</s0>
<s5>25</s5>
</fC07>
<fC07 i1="06" i2="X" l="ENG"><s0>Encephalon</s0>
<s5>25</s5>
</fC07>
<fC07 i1="06" i2="X" l="SPA"><s0>Encéfalo</s0>
<s5>25</s5>
</fC07>
<fC07 i1="07" i2="X" l="FRE"><s0>Système nerveux central</s0>
<s5>26</s5>
</fC07>
<fC07 i1="07" i2="X" l="ENG"><s0>Central nervous system</s0>
<s5>26</s5>
</fC07>
<fC07 i1="07" i2="X" l="SPA"><s0>Sistema nervioso central</s0>
<s5>26</s5>
</fC07>
<fN21><s1>231</s1>
</fN21>
<fN44 i1="01"><s1>OTO</s1>
</fN44>
<fN82><s1>OTO</s1>
</fN82>
</pA>
</standard>
</inist>
</record>

Pour manipuler ce document sous Unix (Dilib)

EXPLOR_STEP=$WICRI_ROOT/Wicri/Canada/explor/ParkinsonCanadaV1/Data/PascalFrancis/Curation

HfdSelect -h $EXPLOR_STEP/biblio.hfd -nk 000675 | SxmlIndent | more

HfdSelect -h $EXPLOR_AREA/Data/PascalFrancis/Curation/biblio.hfd -nk 000675 | SxmlIndent | more

Pour mettre un lien sur cette page dans le réseau Wicri

{{Explor lien
   |wiki=    Wicri/Canada
   |area=    ParkinsonCanadaV1
   |flux=    PascalFrancis
   |étape=   Curation
   |type=    RBID
   |clé=     Pascal:08-0364351
   |texte=   NEUROTOXIC LESIONS AT THE VENTRAL MESOPONTINE JUNCTION CHANGE SLEEP TIME AND MUSCLE ACTIVITY DURING SLEEP : AN ANIMAL MODEL OF MOTOR DISORDERS IN SLEEP
}}

This area was generated with Dilib version V0.6.29.
Data generation: Thu May 4 22:20:19 2017. Site generation: Fri Dec 23 23:17:26 2022

	La maladie de Parkinson au Canada (serveur d'exploration)
	Attention, ce site est en cours de développement ! Attention, site généré par des moyens informatiques à partir de corpus bruts. Les informations ne sont donc pas validées.

La maladie de Parkinson au Canada (serveur d'exploration)

NEUROTOXIC LESIONS AT THE VENTRAL MESOPONTINE JUNCTION CHANGE SLEEP TIME AND MUSCLE ACTIVITY DURING SLEEP : AN ANIMAL MODEL OF MOTOR DISORDERS IN SLEEP

NEUROTOXIC LESIONS AT THE VENTRAL MESOPONTINE JUNCTION CHANGE SLEEP TIME AND MUSCLE ACTIVITY DURING SLEEP : AN ANIMAL MODEL OF MOTOR DISORDERS IN SLEEP

Source :

Descripteurs français

English descriptors

Abstract

Links toward previous steps (curation, corpus...)

Links to Exploration step

Le document en format XML

Pour manipuler ce document sous Unix (Dilib)

Pour mettre un lien sur cette page dans le réseau Wicri