Subthalamic nucleus stimulation induces deficits in decoding emotional facial expressions in Parkinson's disease
Identifieur interne : 000334 ( PascalFrancis/Curation ); précédent : 000333; suivant : 000335Subthalamic nucleus stimulation induces deficits in decoding emotional facial expressions in Parkinson's disease
Auteurs : K. Dujardin [France] ; S. Blairy [Belgique] ; L. Defebvre [France] ; P. Krystkowiak [France] ; U. Hess [Canada] ; S. Blond [France] ; A. Destee [France]Source :
- Journal of neurology, neurosurgery and psychiatry [ 0022-3050 ] ; 2004.
Descripteurs français
- Pascal (Inist)
English descriptors
Abstract
Background: Bilateral subthalamic nucleus (STN) stimulation is recognised as a treatment for parkinsonian patients with severe levodopa related motor complications. Although adverse effects are infrequent, some behavioural disturbances have been reported. Objective: To investigate the consequences of STN stimulation on emotional information processing in Parkinson's disease by assessing the performance of an emotional facial expression (EFE) decoding task in a group of patients before and after surgery. Methods: 12 non-demented patients with Parkinson's disease were studied. They were assessed one month before surgery and three months after. Their ability to decode EFEs was assessed using a standardised quantitative task. Overall cognitive function, executive function, visuospatial perception, depression, and anxiety were also measured. Twelve healthy controls were matched for age, sex, and duration of education. Results: Before surgery, the patients showed no impairment in EFE decoding compared with the controls. Their overall cognitive status was preserved but they had a moderate dysexecutive syndrome. Three months after surgery, they had significant impairment of EFE decoding. This was not related to their overall cognitive status or to depression/anxiety scores. Visuospatial perception was not impaired. There was no change in the extent of the dysexecutive syndrome except for a reduction in phonemic word fluency. Conclusions: Bilateral STN stimulation disturbs negative emotional information processing in Parkinson's disease. The impairment appears specific and unrelated to certain secondary variables. This behavioural complication of STN may have implications for the patient's social life.
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Blairy</name><affiliation wicri:level="1"><inist:fA14 i1="03"><s1>Psychiatry Department, Brugmann University Hospital</s1><s2>Brussels</s2><s3>BEL</s3><sZ>2 aut.</sZ></inist:fA14><country>Belgique</country></affiliation></author><author><name sortKey="Defebvre, L" sort="Defebvre, L" uniqKey="Defebvre L" first="L." last="Defebvre">L. Defebvre</name><affiliation wicri:level="1"><inist:fA14 i1="01"><s1>Neurology and Movement Disorders Unit, EA2683, University of Lille</s1><s2>Lille</s2><s3>FRA</s3><sZ>1 aut.</sZ><sZ>3 aut.</sZ><sZ>4 aut.</sZ><sZ>7 aut.</sZ></inist:fA14><country>France</country></affiliation><affiliation wicri:level="1"><inist:fA14 i1="02"><s1>University Hospital</s1><s2>Lille</s2><s3>FRA</s3><sZ>1 aut.</sZ><sZ>3 aut.</sZ><sZ>4 aut.</sZ><sZ>7 aut.</sZ></inist:fA14><country>France</country></affiliation></author><author><name sortKey="Krystkowiak, P" sort="Krystkowiak, P" uniqKey="Krystkowiak P" first="P." last="Krystkowiak">P. Krystkowiak</name><affiliation wicri:level="1"><inist:fA14 i1="01"><s1>Neurology and Movement Disorders Unit, EA2683, University of Lille</s1><s2>Lille</s2><s3>FRA</s3><sZ>1 aut.</sZ><sZ>3 aut.</sZ><sZ>4 aut.</sZ><sZ>7 aut.</sZ></inist:fA14><country>France</country></affiliation><affiliation wicri:level="1"><inist:fA14 i1="02"><s1>University Hospital</s1><s2>Lille</s2><s3>FRA</s3><sZ>1 aut.</sZ><sZ>3 aut.</sZ><sZ>4 aut.</sZ><sZ>7 aut.</sZ></inist:fA14><country>France</country></affiliation></author><author><name sortKey="Hess, U" sort="Hess, U" uniqKey="Hess U" first="U." last="Hess">U. Hess</name><affiliation wicri:level="1"><inist:fA14 i1="04"><s1>Psychology Department, University of Quebec at Montreal</s1><s2>Montreal</s2><s3>CAN</s3><sZ>5 aut.</sZ></inist:fA14><country>Canada</country></affiliation></author><author><name sortKey="Blond, S" sort="Blond, S" uniqKey="Blond S" first="S." last="Blond">S. Blond</name><affiliation wicri:level="1"><inist:fA14 i1="05"><s1>Neurosurgery Department, EA2683, University of Lille 2 and Lille University Hospital</s1><s2>Lille</s2><s3>FRA</s3><sZ>6 aut.</sZ></inist:fA14><country>France</country></affiliation></author><author><name sortKey="Destee, A" sort="Destee, A" uniqKey="Destee A" first="A." last="Destee">A. Destee</name><affiliation wicri:level="1"><inist:fA14 i1="01"><s1>Neurology and Movement Disorders Unit, EA2683, University of Lille</s1><s2>Lille</s2><s3>FRA</s3><sZ>1 aut.</sZ><sZ>3 aut.</sZ><sZ>4 aut.</sZ><sZ>7 aut.</sZ></inist:fA14><country>France</country></affiliation><affiliation wicri:level="1"><inist:fA14 i1="02"><s1>University Hospital</s1><s2>Lille</s2><s3>FRA</s3><sZ>1 aut.</sZ><sZ>3 aut.</sZ><sZ>4 aut.</sZ><sZ>7 aut.</sZ></inist:fA14><country>France</country></affiliation></author></titleStmt><publicationStmt><idno type="wicri:source">INIST</idno><idno type="inist">04-0363325</idno><date when="2004">2004</date><idno type="stanalyst">PASCAL 04-0363325 INIST</idno><idno type="RBID">Pascal:04-0363325</idno><idno type="wicri:Area/PascalFrancis/Corpus">000989</idno><idno type="wicri:Area/PascalFrancis/Curation">000334</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en" level="a">Subthalamic nucleus stimulation induces deficits in decoding emotional facial expressions in Parkinson's disease</title><author><name sortKey="Dujardin, K" sort="Dujardin, K" uniqKey="Dujardin K" first="K." last="Dujardin">K. Dujardin</name><affiliation wicri:level="1"><inist:fA14 i1="01"><s1>Neurology and Movement Disorders Unit, EA2683, University of Lille</s1><s2>Lille</s2><s3>FRA</s3><sZ>1 aut.</sZ><sZ>3 aut.</sZ><sZ>4 aut.</sZ><sZ>7 aut.</sZ></inist:fA14><country>France</country></affiliation><affiliation wicri:level="1"><inist:fA14 i1="02"><s1>University Hospital</s1><s2>Lille</s2><s3>FRA</s3><sZ>1 aut.</sZ><sZ>3 aut.</sZ><sZ>4 aut.</sZ><sZ>7 aut.</sZ></inist:fA14><country>France</country></affiliation></author><author><name sortKey="Blairy, S" sort="Blairy, S" uniqKey="Blairy S" first="S." last="Blairy">S. Blairy</name><affiliation wicri:level="1"><inist:fA14 i1="03"><s1>Psychiatry Department, Brugmann University Hospital</s1><s2>Brussels</s2><s3>BEL</s3><sZ>2 aut.</sZ></inist:fA14><country>Belgique</country></affiliation></author><author><name sortKey="Defebvre, L" sort="Defebvre, L" uniqKey="Defebvre L" first="L." last="Defebvre">L. Defebvre</name><affiliation wicri:level="1"><inist:fA14 i1="01"><s1>Neurology and Movement Disorders Unit, EA2683, University of Lille</s1><s2>Lille</s2><s3>FRA</s3><sZ>1 aut.</sZ><sZ>3 aut.</sZ><sZ>4 aut.</sZ><sZ>7 aut.</sZ></inist:fA14><country>France</country></affiliation><affiliation wicri:level="1"><inist:fA14 i1="02"><s1>University Hospital</s1><s2>Lille</s2><s3>FRA</s3><sZ>1 aut.</sZ><sZ>3 aut.</sZ><sZ>4 aut.</sZ><sZ>7 aut.</sZ></inist:fA14><country>France</country></affiliation></author><author><name sortKey="Krystkowiak, P" sort="Krystkowiak, P" uniqKey="Krystkowiak P" first="P." last="Krystkowiak">P. Krystkowiak</name><affiliation wicri:level="1"><inist:fA14 i1="01"><s1>Neurology and Movement Disorders Unit, EA2683, University of Lille</s1><s2>Lille</s2><s3>FRA</s3><sZ>1 aut.</sZ><sZ>3 aut.</sZ><sZ>4 aut.</sZ><sZ>7 aut.</sZ></inist:fA14><country>France</country></affiliation><affiliation wicri:level="1"><inist:fA14 i1="02"><s1>University Hospital</s1><s2>Lille</s2><s3>FRA</s3><sZ>1 aut.</sZ><sZ>3 aut.</sZ><sZ>4 aut.</sZ><sZ>7 aut.</sZ></inist:fA14><country>France</country></affiliation></author><author><name sortKey="Hess, U" sort="Hess, U" uniqKey="Hess U" first="U." last="Hess">U. Hess</name><affiliation wicri:level="1"><inist:fA14 i1="04"><s1>Psychology Department, University of Quebec at Montreal</s1><s2>Montreal</s2><s3>CAN</s3><sZ>5 aut.</sZ></inist:fA14><country>Canada</country></affiliation></author><author><name sortKey="Blond, S" sort="Blond, S" uniqKey="Blond S" first="S." last="Blond">S. Blond</name><affiliation wicri:level="1"><inist:fA14 i1="05"><s1>Neurosurgery Department, EA2683, University of Lille 2 and Lille University Hospital</s1><s2>Lille</s2><s3>FRA</s3><sZ>6 aut.</sZ></inist:fA14><country>France</country></affiliation></author><author><name sortKey="Destee, A" sort="Destee, A" uniqKey="Destee A" first="A." last="Destee">A. Destee</name><affiliation wicri:level="1"><inist:fA14 i1="01"><s1>Neurology and Movement Disorders Unit, EA2683, University of Lille</s1><s2>Lille</s2><s3>FRA</s3><sZ>1 aut.</sZ><sZ>3 aut.</sZ><sZ>4 aut.</sZ><sZ>7 aut.</sZ></inist:fA14><country>France</country></affiliation><affiliation wicri:level="1"><inist:fA14 i1="02"><s1>University Hospital</s1><s2>Lille</s2><s3>FRA</s3><sZ>1 aut.</sZ><sZ>3 aut.</sZ><sZ>4 aut.</sZ><sZ>7 aut.</sZ></inist:fA14><country>France</country></affiliation></author></analytic><series><title level="j" type="main">Journal of neurology, neurosurgery and psychiatry</title><title level="j" type="abbreviated">J. neurol. neurosurg. psychiatry</title><idno type="ISSN">0022-3050</idno><imprint><date when="2004">2004</date></imprint></series></biblStruct></sourceDesc><seriesStmt><title level="j" type="main">Journal of neurology, neurosurgery and psychiatry</title><title level="j" type="abbreviated">J. neurol. neurosurg. psychiatry</title><idno type="ISSN">0022-3050</idno></seriesStmt></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Facial expression</term><term>Nervous system diseases</term><term>Parkinson disease</term><term>Subthalamic nucleus</term></keywords><keywords scheme="Pascal" xml:lang="fr"><term>Parkinson maladie</term><term>Noyau sousthalamique</term><term>Mimique</term><term>Système nerveux pathologie</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">Background: Bilateral subthalamic nucleus (STN) stimulation is recognised as a treatment for parkinsonian patients with severe levodopa related motor complications. Although adverse effects are infrequent, some behavioural disturbances have been reported. Objective: To investigate the consequences of STN stimulation on emotional information processing in Parkinson's disease by assessing the performance of an emotional facial expression (EFE) decoding task in a group of patients before and after surgery. Methods: 12 non-demented patients with Parkinson's disease were studied. They were assessed one month before surgery and three months after. Their ability to decode EFEs was assessed using a standardised quantitative task. Overall cognitive function, executive function, visuospatial perception, depression, and anxiety were also measured. Twelve healthy controls were matched for age, sex, and duration of education. Results: Before surgery, the patients showed no impairment in EFE decoding compared with the controls. Their overall cognitive status was preserved but they had a moderate dysexecutive syndrome. Three months after surgery, they had significant impairment of EFE decoding. This was not related to their overall cognitive status or to depression/anxiety scores. Visuospatial perception was not impaired. There was no change in the extent of the dysexecutive syndrome except for a reduction in phonemic word fluency. Conclusions: Bilateral STN stimulation disturbs negative emotional information processing in Parkinson's disease. The impairment appears specific and unrelated to certain secondary variables. This behavioural complication of STN may have implications for the patient's social life.</div></front></TEI><inist><standard h6="B"><pA><fA01 i1="01" i2="1"><s0>0022-3050</s0></fA01><fA02 i1="01"><s0>JNNPAU</s0></fA02><fA03 i2="1"><s0>J. neurol. neurosurg. psychiatry</s0></fA03><fA05><s2>75</s2></fA05><fA06><s2>2</s2></fA06><fA08 i1="01" i2="1" l="ENG"><s1>Subthalamic nucleus stimulation induces deficits in decoding emotional facial expressions in Parkinson's disease</s1></fA08><fA11 i1="01" i2="1"><s1>DUJARDIN (K.)</s1></fA11><fA11 i1="02" i2="1"><s1>BLAIRY (S.)</s1></fA11><fA11 i1="03" i2="1"><s1>DEFEBVRE (L.)</s1></fA11><fA11 i1="04" i2="1"><s1>KRYSTKOWIAK (P.)</s1></fA11><fA11 i1="05" i2="1"><s1>HESS (U.)</s1></fA11><fA11 i1="06" i2="1"><s1>BLOND (S.)</s1></fA11><fA11 i1="07" i2="1"><s1>DESTEE (A.)</s1></fA11><fA14 i1="01"><s1>Neurology and Movement Disorders Unit, EA2683, University of Lille</s1><s2>Lille</s2><s3>FRA</s3><sZ>1 aut.</sZ><sZ>3 aut.</sZ><sZ>4 aut.</sZ><sZ>7 aut.</sZ></fA14><fA14 i1="02"><s1>University Hospital</s1><s2>Lille</s2><s3>FRA</s3><sZ>1 aut.</sZ><sZ>3 aut.</sZ><sZ>4 aut.</sZ><sZ>7 aut.</sZ></fA14><fA14 i1="03"><s1>Psychiatry Department, Brugmann University Hospital</s1><s2>Brussels</s2><s3>BEL</s3><sZ>2 aut.</sZ></fA14><fA14 i1="04"><s1>Psychology Department, University of Quebec at Montreal</s1><s2>Montreal</s2><s3>CAN</s3><sZ>5 aut.</sZ></fA14><fA14 i1="05"><s1>Neurosurgery Department, EA2683, University of Lille 2 and Lille University Hospital</s1><s2>Lille</s2><s3>FRA</s3><sZ>6 aut.</sZ></fA14><fA20><s1>202-208</s1></fA20><fA21><s1>2004</s1></fA21><fA23 i1="01"><s0>ENG</s0></fA23><fA43 i1="01"><s1>INIST</s1><s2>6015</s2><s5>354000114996220070</s5></fA43><fA44><s0>0000</s0><s1>© 2004 INIST-CNRS. All rights reserved.</s1></fA44><fA45><s0>49 ref.</s0></fA45><fA47 i1="01" i2="1"><s0>04-0363325</s0></fA47><fA60><s1>P</s1></fA60><fA61><s0>A</s0></fA61><fA64 i1="01" i2="1"><s0>Journal of neurology, neurosurgery and psychiatry</s0></fA64><fA66 i1="01"><s0>GBR</s0></fA66><fC01 i1="01" l="ENG"><s0>Background: Bilateral subthalamic nucleus (STN) stimulation is recognised as a treatment for parkinsonian patients with severe levodopa related motor complications. Although adverse effects are infrequent, some behavioural disturbances have been reported. Objective: To investigate the consequences of STN stimulation on emotional information processing in Parkinson's disease by assessing the performance of an emotional facial expression (EFE) decoding task in a group of patients before and after surgery. Methods: 12 non-demented patients with Parkinson's disease were studied. They were assessed one month before surgery and three months after. Their ability to decode EFEs was assessed using a standardised quantitative task. Overall cognitive function, executive function, visuospatial perception, depression, and anxiety were also measured. Twelve healthy controls were matched for age, sex, and duration of education. Results: Before surgery, the patients showed no impairment in EFE decoding compared with the controls. Their overall cognitive status was preserved but they had a moderate dysexecutive syndrome. Three months after surgery, they had significant impairment of EFE decoding. This was not related to their overall cognitive status or to depression/anxiety scores. Visuospatial perception was not impaired. There was no change in the extent of the dysexecutive syndrome except for a reduction in phonemic word fluency. Conclusions: Bilateral STN stimulation disturbs negative emotional information processing in Parkinson's disease. The impairment appears specific and unrelated to certain secondary variables. 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