ParkinsonCanadaV1, PascalFrancis, Curation, bibRecord, 000327

Susceptibility to leprosy is associated with PARK2 and PACRG

Identifieur interne : 000327 ( PascalFrancis/Curation ); précédent : 000326; suivant : 000328

Susceptibility to leprosy is associated with PARK2 and PACRG

Auteurs : Marcelo T. Mira [Canada, Brésil, France, Viêt Nam, Pays-Bas] ; Alexandre Alcaïs ; NGUYEN VAN THUC ; Milton O. Moraes ; Celestino Di Flumeri ; VU HONG THAI ; MAL CHI PHUONG ; NGUYEN THU HUONG ; NGUYEN NGOC BA ; PHAM XUAN KHOA ; Euzenir N. Sarno ; Andrea Alter ; Alexandre Montpetit ; Marla E. Moraes ; José R. Moraes ; Carole Dore ; Caroline J. Dallant ; Pierre Lepage ; Andrel Verner ; Esther Van De Vosse ; Thomas J. Hudson ; Laurent Abel ; Erwin Schurr

Source :

Nature : (London) [ 0028-0836 ] ; 2004.

RBID : Pascal:04-0337837

Descripteurs français

Pascal (Inist)
- Lèpre, Prédisposition, Homme, Gène.
Wicri :
- topic : Homme.

English descriptors

KwdEn :
- Gene, Human, Leprosy, Predisposition.

Abstract

Leprosy is caused by Mycobacterium leprae and affects about 700,000 individuals each year'. It has long been thought that leprosy has a strong genetic component², and recently we mapped a leprosy susceptibility locus to chromosome 6 region q25-q26 (ref. 3). Here we investigate this region further by using a systematic association scan of the chromosomal interval most likely to harbour this leprosy susceptibility locus. In 197 Vietnamese families we found a significant association between leprosy I and 17 markers located in a block of approx. 80 kilobases overlapping the 5' regulatory region shared by the Parkinson's disease gene PARK2 and the co-regulated gene PACRG. Possession of as few as two of the 17 risk alleles was highly predictive of leprosy. This was confirmed in a sample of 975 unrelated leprosy cases and controls from Brazil in whom the same alleles were strongly associated with leprosy. Variants in the regulatory region shared by PARK2 and PACRG therefore act as common risk factors for leprosy.

A01	`01`	`1`		`@0 0028-0836`
A02	`01`			`@0 NATUAS`
A03		`1`		`@0 Nature : (Lond.)`
A05				`@2 427`
A06				`@2 6975`
A08	`01`	`1`	`ENG`	`@1 Susceptibility to leprosy is associated with PARK2 and PACRG`
A11	`01`	`1`		`@1 MIRA (Marcelo T.)`
A11	`02`	`1`		`@1 ALCAÏS (Alexandre)`
A11	`03`	`1`		`@1 NGUYEN VAN THUC`
A11	`04`	`1`		`@1 MORAES (Milton O.)`
A11	`05`	`1`		`@1 DI FLUMERI (Celestino)`
A11	`06`	`1`		`@1 VU HONG THAI`
A11	`07`	`1`		`@1 MAL CHI PHUONG`
A11	`08`	`1`		`@1 NGUYEN THU HUONG`
A11	`09`	`1`		`@1 NGUYEN NGOC BA`
A11	`10`	`1`		`@1 PHAM XUAN KHOA`
A11	`11`	`1`		`@1 SARNO (Euzenir N.)`
A11	`12`	`1`		`@1 ALTER (Andrea)`
A11	`13`	`1`		`@1 MONTPETIT (Alexandre)`
A11	`14`	`1`		`@1 MORAES (Marla E.)`
A11	`15`	`1`		`@1 MORAES (José R.)`
A11	`16`	`1`		`@1 DORE (Carole)`
A11	`17`	`1`		`@1 DALLANT (Caroline J.)`
A11	`18`	`1`		`@1 LEPAGE (Pierre)`
A11	`19`	`1`		`@1 VERNER (Andrel)`
A11	`20`	`1`		`@1 VAN DE VOSSE (Esther)`
A11	`21`	`1`		`@1 HUDSON (Thomas J.)`
A11	`22`	`1`		`@1 ABEL (Laurent)`
A11	`23`	`1`		`@1 SCHURR (Erwin)`
A14	`01`			`@1 McGill Centre for the Study of Host Résistance and Departments of Human Genetics, Medicine and Biochemistry, McGill University, 1650 Cedar Avenue @2 Montreal, PQ H3G 1A4 @3 CAN`
A14	`02`			`@1 Centro de Ciências Biológicas e da Saúde, Pontificia Universidade Católica do Paraná. Rua Imaculada Conceição, 1155 @2 CEP 80215-901, Curitiba, Paraná @3 BRA`
A14	`03`			`@1 Laboratoire de Génétique Humaine des Maladies Infectieuses, INSERM U.550, Faculté de Médecine Necker, Université de Paris René Descartes, 156 rue de Vaugirard @2 75015 Paris @3 FRA`
A14	`04`			`@1 Hospital for Dermato-Venereology, Nguyen Thong Street, District 3, Ho Chi Minh City @3 VNM`
A14	`05`			`@1 Leprosy Laboratory, Tropical Medicine Department Oswaldo Cruz Institute, FIOCRUZ 20221-903 Rio de Janeiro @3 BRA`
A14	`06`			`@1 McGill University and Genome Québec Innovation Centre, 740 Docteur Penfield @2 Montreal, PQ H3A 1A4 @3 CAN`
A14	`07`			`@1 Laboratório de Imunogénetica, Instituto Nacional do Cancer, Ministério da @2 Saúde, 20230-130 Rio de Janeiro, RJ @3 BRA`
A14	`08`			`@1 Department of Infections Diseases & Department of Immunohematology and Blood Transfusion, Leiden University Médical Center, Building 1, Albinusdreef 2 @2 2333 ZA Leiden @3 NLD`
A20				`@1 636-640`
A21				`@1 2004`
A23	`01`			`@0 ENG`
A43	`01`			`@1 INIST @2 142 @5 354000110106500220`
A44				`@0 0000 @1 © 2004 INIST-CNRS. All rights reserved.`
A45				`@0 18`
A47	`01`	`1`		`@0 04-0337837`
A60				`@1 P @3 LT`
A61				`@0 A`
A64	`01`	`1`		`@0 Nature : (London)`
A66	`01`			`@0 GBR`
C01	`01`		`ENG`	@0 Leprosy is caused by Mycobacterium leprae and affects about 700,000 individuals each year'. It has long been thought that leprosy has a strong genetic component², and recently we mapped a leprosy susceptibility locus to chromosome 6 region q25-q26 (ref. 3). Here we investigate this region further by using a systematic association scan of the chromosomal interval most likely to harbour this leprosy susceptibility locus. In 197 Vietnamese families we found a significant association between leprosy I and 17 markers located in a block of approx. 80 kilobases overlapping the 5' regulatory region shared by the Parkinson's disease gene PARK2 and the co-regulated gene PACRG. Possession of as few as two of the 17 risk alleles was highly predictive of leprosy. This was confirmed in a sample of 975 unrelated leprosy cases and controls from Brazil in whom the same alleles were strongly associated with leprosy. Variants in the regulatory region shared by PARK2 and PACRG therefore act as common risk factors for leprosy.
C02	`01`	`X`		`@0 002B05A03`
C03	`01`	`X`	`FRE`	`@0 Lèpre @2 NM @5 01`
C03	`01`	`X`	`ENG`	`@0 Leprosy @2 NM @5 01`
C03	`01`	`X`	`SPA`	`@0 Lepra @2 NM @5 01`
C03	`02`	`X`	`FRE`	`@0 Prédisposition @5 02`
C03	`02`	`X`	`ENG`	`@0 Predisposition @5 02`
C03	`02`	`X`	`SPA`	`@0 Predisposición @5 02`
C03	`03`	`X`	`FRE`	`@0 Homme @5 03`
C03	`03`	`X`	`ENG`	`@0 Human @5 03`
C03	`03`	`X`	`SPA`	`@0 Hombre @5 03`
C03	`04`	`X`	`FRE`	`@0 Gène @5 04`
C03	`04`	`X`	`ENG`	`@0 Gene @5 04`
C03	`04`	`X`	`SPA`	`@0 Gen @5 04`
C07	`01`	`X`	`FRE`	`@0 Mycobactériose @2 NM`
C07	`01`	`X`	`ENG`	`@0 Mycobacterial infection @2 NM`
C07	`01`	`X`	`SPA`	`@0 Micobacteriosis @2 NM`
C07	`02`	`X`	`FRE`	`@0 Bactériose @2 NM`
C07	`02`	`X`	`ENG`	`@0 Bacteriosis @2 NM`
C07	`02`	`X`	`SPA`	`@0 Bacteriosis @2 NM`
C07	`03`	`X`	`FRE`	`@0 Infection @2 NM`
C07	`03`	`X`	`ENG`	`@0 Infection @2 NM`
C07	`03`	`X`	`SPA`	`@0 Infección @2 NM`
C07	`04`	`X`	`FRE`	`@0 Peau pathologie @5 37`
C07	`04`	`X`	`ENG`	`@0 Skin disease @5 37`
C07	`04`	`X`	`SPA`	`@0 Piel patología @5 37`
N21				`@1 201`
N44	`01`			`@1 PSI`
N82				`@1 PSI`

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Pascal:04-0337837

Le document en format XML

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<author><name sortKey="Nguyen Ngoc Ba" sort="Nguyen Ngoc Ba" uniqKey="Nguyen Ngoc Ba" last="Nguyen Ngoc Ba">NGUYEN NGOC BA</name>
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<author><name sortKey="Pham Xuan Khoa" sort="Pham Xuan Khoa" uniqKey="Pham Xuan Khoa" last="Pham Xuan Khoa">PHAM XUAN KHOA</name>
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<author><name sortKey="Moraes, Marla E" sort="Moraes, Marla E" uniqKey="Moraes M" first="Marla E." last="Moraes">Marla E. Moraes</name>
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<author><name sortKey="Hudson, Thomas J" sort="Hudson, Thomas J" uniqKey="Hudson T" first="Thomas J." last="Hudson">Thomas J. Hudson</name>
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<affiliation wicri:level="1"><inist:fA14 i1="01"><s1>McGill Centre for the Study of Host Résistance and Departments of Human Genetics, Medicine and Biochemistry, McGill University, 1650 Cedar Avenue</s1>
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<s2>CEP 80215-901, Curitiba, Paraná</s2>
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<affiliation wicri:level="1"><inist:fA14 i1="03"><s1>Laboratoire de Génétique Humaine des Maladies Infectieuses, INSERM U.550, Faculté de Médecine Necker, Université de Paris René Descartes, 156 rue de Vaugirard</s1>
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<country>Brésil</country>
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<affiliation wicri:level="1"><inist:fA14 i1="08"><s1>Department of Infections Diseases & Department of Immunohematology and Blood Transfusion, Leiden University Médical Center, Building 1, Albinusdreef 2</s1>
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<author><name sortKey="Alcais, Alexandre" sort="Alcais, Alexandre" uniqKey="Alcais A" first="Alexandre" last="Alcaïs">Alexandre Alcaïs</name>
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<author><name sortKey="Nguyen Van Thuc" sort="Nguyen Van Thuc" uniqKey="Nguyen Van Thuc" last="Nguyen Van Thuc">NGUYEN VAN THUC</name>
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<author><name sortKey="Moraes, Milton O" sort="Moraes, Milton O" uniqKey="Moraes M" first="Milton O." last="Moraes">Milton O. Moraes</name>
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<author><name sortKey="Di Flumeri, Celestino" sort="Di Flumeri, Celestino" uniqKey="Di Flumeri C" first="Celestino" last="Di Flumeri">Celestino Di Flumeri</name>
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<author><name sortKey="Vu Hong Thai" sort="Vu Hong Thai" uniqKey="Vu Hong Thai" last="Vu Hong Thai">VU HONG THAI</name>
</author>
<author><name sortKey="Mal Chi Phuong" sort="Mal Chi Phuong" uniqKey="Mal Chi Phuong" last="Mal Chi Phuong">MAL CHI PHUONG</name>
</author>
<author><name sortKey="Nguyen Thu Huong" sort="Nguyen Thu Huong" uniqKey="Nguyen Thu Huong" last="Nguyen Thu Huong">NGUYEN THU HUONG</name>
</author>
<author><name sortKey="Nguyen Ngoc Ba" sort="Nguyen Ngoc Ba" uniqKey="Nguyen Ngoc Ba" last="Nguyen Ngoc Ba">NGUYEN NGOC BA</name>
</author>
<author><name sortKey="Pham Xuan Khoa" sort="Pham Xuan Khoa" uniqKey="Pham Xuan Khoa" last="Pham Xuan Khoa">PHAM XUAN KHOA</name>
</author>
<author><name sortKey="Sarno, Euzenir N" sort="Sarno, Euzenir N" uniqKey="Sarno E" first="Euzenir N." last="Sarno">Euzenir N. Sarno</name>
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<author><name sortKey="Alter, Andrea" sort="Alter, Andrea" uniqKey="Alter A" first="Andrea" last="Alter">Andrea Alter</name>
</author>
<author><name sortKey="Montpetit, Alexandre" sort="Montpetit, Alexandre" uniqKey="Montpetit A" first="Alexandre" last="Montpetit">Alexandre Montpetit</name>
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<author><name sortKey="Moraes, Marla E" sort="Moraes, Marla E" uniqKey="Moraes M" first="Marla E." last="Moraes">Marla E. Moraes</name>
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<author><name sortKey="Moraes, Jose R" sort="Moraes, Jose R" uniqKey="Moraes J" first="José R." last="Moraes">José R. Moraes</name>
</author>
<author><name sortKey="Dore, Carole" sort="Dore, Carole" uniqKey="Dore C" first="Carole" last="Dore">Carole Dore</name>
</author>
<author><name sortKey="Dallant, Caroline J" sort="Dallant, Caroline J" uniqKey="Dallant C" first="Caroline J." last="Dallant">Caroline J. Dallant</name>
</author>
<author><name sortKey="Lepage, Pierre" sort="Lepage, Pierre" uniqKey="Lepage P" first="Pierre" last="Lepage">Pierre Lepage</name>
</author>
<author><name sortKey="Verner, Andrel" sort="Verner, Andrel" uniqKey="Verner A" first="Andrel" last="Verner">Andrel Verner</name>
</author>
<author><name sortKey="Van De Vosse, Esther" sort="Van De Vosse, Esther" uniqKey="Van De Vosse E" first="Esther" last="Van De Vosse">Esther Van De Vosse</name>
</author>
<author><name sortKey="Hudson, Thomas J" sort="Hudson, Thomas J" uniqKey="Hudson T" first="Thomas J." last="Hudson">Thomas J. Hudson</name>
</author>
<author><name sortKey="Abel, Laurent" sort="Abel, Laurent" uniqKey="Abel L" first="Laurent" last="Abel">Laurent Abel</name>
</author>
<author><name sortKey="Schurr, Erwin" sort="Schurr, Erwin" uniqKey="Schurr E" first="Erwin" last="Schurr">Erwin Schurr</name>
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</analytic>
<series><title level="j" type="main">Nature : (London)</title>
<title level="j" type="abbreviated">Nature : (Lond.)</title>
<idno type="ISSN">0028-0836</idno>
<imprint><date when="2004">2004</date>
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<title level="j" type="abbreviated">Nature : (Lond.)</title>
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<profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Gene</term>
<term>Human</term>
<term>Leprosy</term>
<term>Predisposition</term>
</keywords>
<keywords scheme="Pascal" xml:lang="fr"><term>Lèpre</term>
<term>Prédisposition</term>
<term>Homme</term>
<term>Gène</term>
</keywords>
<keywords scheme="Wicri" type="topic" xml:lang="fr"><term>Homme</term>
</keywords>
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<front><div type="abstract" xml:lang="en">Leprosy is caused by Mycobacterium leprae and affects about 700,000 individuals each year'. It has long been thought that leprosy has a strong genetic component<sup>2</sup>
, and recently we mapped a leprosy susceptibility locus to chromosome 6 region q25-q26 (ref. 3). Here we investigate this region further by using a systematic association scan of the chromosomal interval most likely to harbour this leprosy susceptibility locus. In 197 Vietnamese families we found a significant association between leprosy I and 17 markers located in a block of approx. 80 kilobases overlapping the 5' regulatory region shared by the Parkinson's disease gene PARK2 and the co-regulated gene PACRG. Possession of as few as two of the 17 risk alleles was highly predictive of leprosy. This was confirmed in a sample of 975 unrelated leprosy cases and controls from Brazil in whom the same alleles were strongly associated with leprosy. Variants in the regulatory region shared by PARK2 and PACRG therefore act as common risk factors for leprosy.</div>
</front>
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<inist><standard h6="B"><pA><fA01 i1="01" i2="1"><s0>0028-0836</s0>
</fA01>
<fA02 i1="01"><s0>NATUAS</s0>
</fA02>
<fA03 i2="1"><s0>Nature : (Lond.)</s0>
</fA03>
<fA05><s2>427</s2>
</fA05>
<fA06><s2>6975</s2>
</fA06>
<fA08 i1="01" i2="1" l="ENG"><s1>Susceptibility to leprosy is associated with PARK2 and PACRG</s1>
</fA08>
<fA11 i1="01" i2="1"><s1>MIRA (Marcelo T.)</s1>
</fA11>
<fA11 i1="02" i2="1"><s1>ALCAÏS (Alexandre)</s1>
</fA11>
<fA11 i1="03" i2="1"><s1>NGUYEN VAN THUC</s1>
</fA11>
<fA11 i1="04" i2="1"><s1>MORAES (Milton O.)</s1>
</fA11>
<fA11 i1="05" i2="1"><s1>DI FLUMERI (Celestino)</s1>
</fA11>
<fA11 i1="06" i2="1"><s1>VU HONG THAI</s1>
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<fA11 i1="07" i2="1"><s1>MAL CHI PHUONG</s1>
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<fA11 i1="08" i2="1"><s1>NGUYEN THU HUONG</s1>
</fA11>
<fA11 i1="09" i2="1"><s1>NGUYEN NGOC BA</s1>
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<fA11 i1="10" i2="1"><s1>PHAM XUAN KHOA</s1>
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<fA11 i1="11" i2="1"><s1>SARNO (Euzenir N.)</s1>
</fA11>
<fA11 i1="12" i2="1"><s1>ALTER (Andrea)</s1>
</fA11>
<fA11 i1="13" i2="1"><s1>MONTPETIT (Alexandre)</s1>
</fA11>
<fA11 i1="14" i2="1"><s1>MORAES (Marla E.)</s1>
</fA11>
<fA11 i1="15" i2="1"><s1>MORAES (José R.)</s1>
</fA11>
<fA11 i1="16" i2="1"><s1>DORE (Carole)</s1>
</fA11>
<fA11 i1="17" i2="1"><s1>DALLANT (Caroline J.)</s1>
</fA11>
<fA11 i1="18" i2="1"><s1>LEPAGE (Pierre)</s1>
</fA11>
<fA11 i1="19" i2="1"><s1>VERNER (Andrel)</s1>
</fA11>
<fA11 i1="20" i2="1"><s1>VAN DE VOSSE (Esther)</s1>
</fA11>
<fA11 i1="21" i2="1"><s1>HUDSON (Thomas J.)</s1>
</fA11>
<fA11 i1="22" i2="1"><s1>ABEL (Laurent)</s1>
</fA11>
<fA11 i1="23" i2="1"><s1>SCHURR (Erwin)</s1>
</fA11>
<fA14 i1="01"><s1>McGill Centre for the Study of Host Résistance and Departments of Human Genetics, Medicine and Biochemistry, McGill University, 1650 Cedar Avenue</s1>
<s2>Montreal, PQ H3G 1A4</s2>
<s3>CAN</s3>
</fA14>
<fA14 i1="02"><s1>Centro de Ciências Biológicas e da Saúde, Pontificia Universidade Católica do Paraná. Rua Imaculada Conceição, 1155</s1>
<s2>CEP 80215-901, Curitiba, Paraná</s2>
<s3>BRA</s3>
</fA14>
<fA14 i1="03"><s1>Laboratoire de Génétique Humaine des Maladies Infectieuses, INSERM U.550, Faculté de Médecine Necker, Université de Paris René Descartes, 156 rue de Vaugirard</s1>
<s2>75015 Paris</s2>
<s3>FRA</s3>
</fA14>
<fA14 i1="04"><s1>Hospital for Dermato-Venereology, Nguyen Thong Street, District 3, Ho Chi Minh City</s1>
<s3>VNM</s3>
</fA14>
<fA14 i1="05"><s1>Leprosy Laboratory, Tropical Medicine Department Oswaldo Cruz Institute, FIOCRUZ 20221-903 Rio de Janeiro</s1>
<s3>BRA</s3>
</fA14>
<fA14 i1="06"><s1>McGill University and Genome Québec Innovation Centre, 740 Docteur Penfield</s1>
<s2>Montreal, PQ H3A 1A4</s2>
<s3>CAN</s3>
</fA14>
<fA14 i1="07"><s1>Laboratório de Imunogénetica, Instituto Nacional do Cancer, Ministério da</s1>
<s2>Saúde, 20230-130 Rio de Janeiro, RJ</s2>
<s3>BRA</s3>
</fA14>
<fA14 i1="08"><s1>Department of Infections Diseases & Department of Immunohematology and Blood Transfusion, Leiden University Médical Center, Building 1, Albinusdreef 2</s1>
<s2>2333 ZA Leiden</s2>
<s3>NLD</s3>
</fA14>
<fA20><s1>636-640</s1>
</fA20>
<fA21><s1>2004</s1>
</fA21>
<fA23 i1="01"><s0>ENG</s0>
</fA23>
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<s1>© 2004 INIST-CNRS. All rights reserved.</s1>
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<fA45><s0>18</s0>
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<fA47 i1="01" i2="1"><s0>04-0337837</s0>
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<fA60><s1>P</s1>
<s3>LT</s3>
</fA60>
<fA61><s0>A</s0>
</fA61>
<fA64 i1="01" i2="1"><s0>Nature : (London)</s0>
</fA64>
<fA66 i1="01"><s0>GBR</s0>
</fA66>
<fC01 i1="01" l="ENG"><s0>Leprosy is caused by Mycobacterium leprae and affects about 700,000 individuals each year'. It has long been thought that leprosy has a strong genetic component<sup>2</sup>
, and recently we mapped a leprosy susceptibility locus to chromosome 6 region q25-q26 (ref. 3). Here we investigate this region further by using a systematic association scan of the chromosomal interval most likely to harbour this leprosy susceptibility locus. In 197 Vietnamese families we found a significant association between leprosy I and 17 markers located in a block of approx. 80 kilobases overlapping the 5' regulatory region shared by the Parkinson's disease gene PARK2 and the co-regulated gene PACRG. Possession of as few as two of the 17 risk alleles was highly predictive of leprosy. This was confirmed in a sample of 975 unrelated leprosy cases and controls from Brazil in whom the same alleles were strongly associated with leprosy. Variants in the regulatory region shared by PARK2 and PACRG therefore act as common risk factors for leprosy.</s0>
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<fC02 i1="01" i2="X"><s0>002B05A03</s0>
</fC02>
<fC03 i1="01" i2="X" l="FRE"><s0>Lèpre</s0>
<s2>NM</s2>
<s5>01</s5>
</fC03>
<fC03 i1="01" i2="X" l="ENG"><s0>Leprosy</s0>
<s2>NM</s2>
<s5>01</s5>
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<fC03 i1="01" i2="X" l="SPA"><s0>Lepra</s0>
<s2>NM</s2>
<s5>01</s5>
</fC03>
<fC03 i1="02" i2="X" l="FRE"><s0>Prédisposition</s0>
<s5>02</s5>
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<fC03 i1="02" i2="X" l="ENG"><s0>Predisposition</s0>
<s5>02</s5>
</fC03>
<fC03 i1="02" i2="X" l="SPA"><s0>Predisposición</s0>
<s5>02</s5>
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<fC03 i1="03" i2="X" l="FRE"><s0>Homme</s0>
<s5>03</s5>
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<fC03 i1="03" i2="X" l="ENG"><s0>Human</s0>
<s5>03</s5>
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<fC03 i1="03" i2="X" l="SPA"><s0>Hombre</s0>
<s5>03</s5>
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<s5>04</s5>
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<fC03 i1="04" i2="X" l="ENG"><s0>Gene</s0>
<s5>04</s5>
</fC03>
<fC03 i1="04" i2="X" l="SPA"><s0>Gen</s0>
<s5>04</s5>
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<fC07 i1="01" i2="X" l="FRE"><s0>Mycobactériose</s0>
<s2>NM</s2>
</fC07>
<fC07 i1="01" i2="X" l="ENG"><s0>Mycobacterial infection</s0>
<s2>NM</s2>
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<fC07 i1="01" i2="X" l="SPA"><s0>Micobacteriosis</s0>
<s2>NM</s2>
</fC07>
<fC07 i1="02" i2="X" l="FRE"><s0>Bactériose</s0>
<s2>NM</s2>
</fC07>
<fC07 i1="02" i2="X" l="ENG"><s0>Bacteriosis</s0>
<s2>NM</s2>
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<fC07 i1="02" i2="X" l="SPA"><s0>Bacteriosis</s0>
<s2>NM</s2>
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<fC07 i1="03" i2="X" l="FRE"><s0>Infection</s0>
<s2>NM</s2>
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<fC07 i1="03" i2="X" l="ENG"><s0>Infection</s0>
<s2>NM</s2>
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<fC07 i1="03" i2="X" l="SPA"><s0>Infección</s0>
<s2>NM</s2>
</fC07>
<fC07 i1="04" i2="X" l="FRE"><s0>Peau pathologie</s0>
<s5>37</s5>
</fC07>
<fC07 i1="04" i2="X" l="ENG"><s0>Skin disease</s0>
<s5>37</s5>
</fC07>
<fC07 i1="04" i2="X" l="SPA"><s0>Piel patología</s0>
<s5>37</s5>
</fC07>
<fN21><s1>201</s1>
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	La maladie de Parkinson au Canada (serveur d'exploration)
	Attention, ce site est en cours de développement ! Attention, site généré par des moyens informatiques à partir de corpus bruts. Les informations ne sont donc pas validées.

La maladie de Parkinson au Canada (serveur d'exploration)

Susceptibility to leprosy is associated with PARK2 and PACRG

Susceptibility to leprosy is associated with PARK2 and PACRG

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