ParkinsonCanadaV1, PascalFrancis, Curation, bibRecord, 000315

Quality of life in early Parkinson's disease: Impact of dyskinesias and motor fluctuations

Identifieur interne : 000315 ( PascalFrancis/Curation ); précédent : 000314; suivant : 000316

Quality of life in early Parkinson's disease: Impact of dyskinesias and motor fluctuations

Auteurs : Connie Marras [Canada] ; Anthony Lang [Canada] ; Murray Krahn [Canada] ; George Tomlinson [Canada] ; Gary Naglie [Canada]

Source :

Movement disorders [ 0885-3185 ] ; 2004.

RBID : Pascal:04-0232991

Descripteurs français

Pascal (Inist)
- Parkinson maladie, Qualité vie, Fluctuation, Dyskinésie, Système nerveux pathologie.

English descriptors

KwdEn :
- Dyskinesia, Fluctuations, Nervous system diseases, Parkinson disease, Quality of life.

Abstract

The impact of dyskinesias and motor fluctuations on quality of life (QOL) at various stages in the course of Parkinsons disease (PD) is not well understood. In 301 subjects with early PD enrolled in a clinical trial (CALM-PD), we quantified the impact of motor complications on QOL and investigated how this changes over time. We also compared QOL related to demographic and treatment characteristics. The presence of dyskinesias was associated with visual analogue scale (VAS) scores 3.0 of 100 points higher (better) than those without dyskinesias in years I to 2, even when adjusting for Unified Parkinson's Disease Rating Scale (UPDRS) motor scores. The positive association between dyskinesias and QOL scores was more marked in older patients. In years 3 to 4, dyskinesias no longer had a significant relationship with QOL. Younger subjects had higher VAS scores. Gender, motor fluctuations, and treatment regimen had no significant association with QOL, although a trend was found toward a small negative effect of motor fluctuations on QOL. We conclude that motor complications that occur within the first 4 years of treatment of PD do not have a significant negative effect on quality of life as measured by a visual analogue scale for most patients.

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A08	`01`	`1`	`ENG`	`@1 Quality of life in early Parkinson's disease: Impact of dyskinesias and motor fluctuations`
A11	`01`	`1`		`@1 MARRAS (Connie)`
A11	`02`	`1`		`@1 LANG (Anthony)`
A11	`03`	`1`		`@1 KRAHN (Murray)`
A11	`04`	`1`		`@1 TOMLINSON (George)`
A11	`05`	`1`		`@1 NAGLIE (Gary)`
A14	`01`			`@1 Division of Neurology, Toronto Western Hospital, University Health Network, University of Toronto @2 Toronto, Ontario @3 CAN @Z 1 aut. @Z 2 aut.`
A14	`02`			`@1 Division of Clinical Decision Making and Health Care Research, Toronto General Research Institute, Toronto General Hospital, University Health Network @2 Toronto, Ontario @3 CAN @Z 3 aut. @Z 5 aut.`
A14	`03`			`@1 Division of General Internal Medicine, University Health Network @2 Toronto, Ontario @3 CAN @Z 3 aut. @Z 5 aut.`
A14	`04`			`@1 Departments of Medicine and Health Policy, Management and Evaluation, University of Toronto @2 Toronto, Ontario @3 CAN @Z 3 aut.`
A14	`05`			`@1 Department of Radiology, University Health Network and Department of Biostatistics, University of Toronto @2 Toronto, Ontario @3 CAN @Z 4 aut.`
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A44				`@0 0000 @1 © 2004 INIST-CNRS. All rights reserved.`
A45				`@0 15 ref.`
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C01	`01`		`ENG`	@0 The impact of dyskinesias and motor fluctuations on quality of life (QOL) at various stages in the course of Parkinsons disease (PD) is not well understood. In 301 subjects with early PD enrolled in a clinical trial (CALM-PD), we quantified the impact of motor complications on QOL and investigated how this changes over time. We also compared QOL related to demographic and treatment characteristics. The presence of dyskinesias was associated with visual analogue scale (VAS) scores 3.0 of 100 points higher (better) than those without dyskinesias in years I to 2, even when adjusting for Unified Parkinson's Disease Rating Scale (UPDRS) motor scores. The positive association between dyskinesias and QOL scores was more marked in older patients. In years 3 to 4, dyskinesias no longer had a significant relationship with QOL. Younger subjects had higher VAS scores. Gender, motor fluctuations, and treatment regimen had no significant association with QOL, although a trend was found toward a small negative effect of motor fluctuations on QOL. We conclude that motor complications that occur within the first 4 years of treatment of PD do not have a significant negative effect on quality of life as measured by a visual analogue scale for most patients.
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C03	`02`	`X`	`FRE`	`@0 Qualité vie @5 02`
C03	`02`	`X`	`ENG`	`@0 Quality of life @5 02`
C03	`02`	`X`	`SPA`	`@0 Calidad vida @5 02`
C03	`03`	`X`	`FRE`	`@0 Fluctuation @5 03`
C03	`03`	`X`	`ENG`	`@0 Fluctuations @5 03`
C03	`03`	`X`	`SPA`	`@0 Fluctuación @5 03`
C03	`04`	`X`	`FRE`	`@0 Dyskinésie @5 04`
C03	`04`	`X`	`ENG`	`@0 Dyskinesia @5 04`
C03	`04`	`X`	`SPA`	`@0 Disquinesia @5 04`
C03	`05`	`X`	`FRE`	`@0 Système nerveux pathologie @5 07`
C03	`05`	`X`	`ENG`	`@0 Nervous system diseases @5 07`
C03	`05`	`X`	`SPA`	`@0 Sistema nervioso patología @5 07`
C07	`01`	`X`	`FRE`	`@0 Encéphale pathologie @5 37`
C07	`01`	`X`	`ENG`	`@0 Cerebral disorder @5 37`
C07	`01`	`X`	`SPA`	`@0 Encéfalo patología @5 37`
C07	`02`	`X`	`FRE`	`@0 Extrapyramidal syndrome @5 38`
C07	`02`	`X`	`ENG`	`@0 Extrapyramidal syndrome @5 38`
C07	`02`	`X`	`SPA`	`@0 Extrapiramidal síndrome @5 38`
C07	`03`	`X`	`FRE`	`@0 Maladie dégénérative @5 39`
C07	`03`	`X`	`ENG`	`@0 Degenerative disease @5 39`
C07	`03`	`X`	`SPA`	`@0 Enfermedad degenerativa @5 39`
C07	`04`	`X`	`FRE`	`@0 Système nerveux central pathologie @5 40`
C07	`04`	`X`	`ENG`	`@0 Central nervous system disease @5 40`
C07	`04`	`X`	`SPA`	`@0 Sistema nervosio central patología @5 40`
C07	`05`	`X`	`FRE`	`@0 Mouvement involontaire @5 41`
C07	`05`	`X`	`ENG`	`@0 Involuntary movement @5 41`
C07	`05`	`X`	`SPA`	`@0 Movimiento involuntario @5 41`
C07	`06`	`X`	`FRE`	`@0 Trouble neurologique @5 42`
C07	`06`	`X`	`ENG`	`@0 Neurological disorder @5 42`
C07	`06`	`X`	`SPA`	`@0 Trastorno neurológico @5 42`
N21				`@1 152`
N82				`@1 OTO`

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Le document en format XML

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<front><div type="abstract" xml:lang="en">The impact of dyskinesias and motor fluctuations on quality of life (QOL) at various stages in the course of Parkinsons disease (PD) is not well understood. In 301 subjects with early PD enrolled in a clinical trial (CALM-PD), we quantified the impact of motor complications on QOL and investigated how this changes over time. We also compared QOL related to demographic and treatment characteristics. The presence of dyskinesias was associated with visual analogue scale (VAS) scores 3.0 of 100 points higher (better) than those without dyskinesias in years I to 2, even when adjusting for Unified Parkinson's Disease Rating Scale (UPDRS) motor scores. The positive association between dyskinesias and QOL scores was more marked in older patients. In years 3 to 4, dyskinesias no longer had a significant relationship with QOL. Younger subjects had higher VAS scores. Gender, motor fluctuations, and treatment regimen had no significant association with QOL, although a trend was found toward a small negative effect of motor fluctuations on QOL. We conclude that motor complications that occur within the first 4 years of treatment of PD do not have a significant negative effect on quality of life as measured by a visual analogue scale for most patients.</div>
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<fC01 i1="01" l="ENG"><s0>The impact of dyskinesias and motor fluctuations on quality of life (QOL) at various stages in the course of Parkinsons disease (PD) is not well understood. In 301 subjects with early PD enrolled in a clinical trial (CALM-PD), we quantified the impact of motor complications on QOL and investigated how this changes over time. We also compared QOL related to demographic and treatment characteristics. The presence of dyskinesias was associated with visual analogue scale (VAS) scores 3.0 of 100 points higher (better) than those without dyskinesias in years I to 2, even when adjusting for Unified Parkinson's Disease Rating Scale (UPDRS) motor scores. The positive association between dyskinesias and QOL scores was more marked in older patients. In years 3 to 4, dyskinesias no longer had a significant relationship with QOL. Younger subjects had higher VAS scores. Gender, motor fluctuations, and treatment regimen had no significant association with QOL, although a trend was found toward a small negative effect of motor fluctuations on QOL. We conclude that motor complications that occur within the first 4 years of treatment of PD do not have a significant negative effect on quality of life as measured by a visual analogue scale for most patients.</s0>
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<s5>04</s5>
</fC03>
<fC03 i1="04" i2="X" l="ENG"><s0>Dyskinesia</s0>
<s5>04</s5>
</fC03>
<fC03 i1="04" i2="X" l="SPA"><s0>Disquinesia</s0>
<s5>04</s5>
</fC03>
<fC03 i1="05" i2="X" l="FRE"><s0>Système nerveux pathologie</s0>
<s5>07</s5>
</fC03>
<fC03 i1="05" i2="X" l="ENG"><s0>Nervous system diseases</s0>
<s5>07</s5>
</fC03>
<fC03 i1="05" i2="X" l="SPA"><s0>Sistema nervioso patología</s0>
<s5>07</s5>
</fC03>
<fC07 i1="01" i2="X" l="FRE"><s0>Encéphale pathologie</s0>
<s5>37</s5>
</fC07>
<fC07 i1="01" i2="X" l="ENG"><s0>Cerebral disorder</s0>
<s5>37</s5>
</fC07>
<fC07 i1="01" i2="X" l="SPA"><s0>Encéfalo patología</s0>
<s5>37</s5>
</fC07>
<fC07 i1="02" i2="X" l="FRE"><s0>Extrapyramidal syndrome</s0>
<s5>38</s5>
</fC07>
<fC07 i1="02" i2="X" l="ENG"><s0>Extrapyramidal syndrome</s0>
<s5>38</s5>
</fC07>
<fC07 i1="02" i2="X" l="SPA"><s0>Extrapiramidal síndrome</s0>
<s5>38</s5>
</fC07>
<fC07 i1="03" i2="X" l="FRE"><s0>Maladie dégénérative</s0>
<s5>39</s5>
</fC07>
<fC07 i1="03" i2="X" l="ENG"><s0>Degenerative disease</s0>
<s5>39</s5>
</fC07>
<fC07 i1="03" i2="X" l="SPA"><s0>Enfermedad degenerativa</s0>
<s5>39</s5>
</fC07>
<fC07 i1="04" i2="X" l="FRE"><s0>Système nerveux central pathologie</s0>
<s5>40</s5>
</fC07>
<fC07 i1="04" i2="X" l="ENG"><s0>Central nervous system disease</s0>
<s5>40</s5>
</fC07>
<fC07 i1="04" i2="X" l="SPA"><s0>Sistema nervosio central patología</s0>
<s5>40</s5>
</fC07>
<fC07 i1="05" i2="X" l="FRE"><s0>Mouvement involontaire</s0>
<s5>41</s5>
</fC07>
<fC07 i1="05" i2="X" l="ENG"><s0>Involuntary movement</s0>
<s5>41</s5>
</fC07>
<fC07 i1="05" i2="X" l="SPA"><s0>Movimiento involuntario</s0>
<s5>41</s5>
</fC07>
<fC07 i1="06" i2="X" l="FRE"><s0>Trouble neurologique</s0>
<s5>42</s5>
</fC07>
<fC07 i1="06" i2="X" l="ENG"><s0>Neurological disorder</s0>
<s5>42</s5>
</fC07>
<fC07 i1="06" i2="X" l="SPA"><s0>Trastorno neurológico</s0>
<s5>42</s5>
</fC07>
<fN21><s1>152</s1>
</fN21>
<fN82><s1>OTO</s1>
</fN82>
</pA>
</standard>
</inist>
</record>

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	La maladie de Parkinson au Canada (serveur d'exploration)
	Attention, ce site est en cours de développement ! Attention, site généré par des moyens informatiques à partir de corpus bruts. Les informations ne sont donc pas validées.

La maladie de Parkinson au Canada (serveur d'exploration)

Quality of life in early Parkinson's disease: Impact of dyskinesias and motor fluctuations

Quality of life in early Parkinson's disease: Impact of dyskinesias and motor fluctuations

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