ParkinsonCanadaV1, PascalFrancis, Curation, bibRecord, 000295

Injury and strain-dependent dopaminergic neuronal degeneration in the substantia nigra of mice after axotomy or MPTP

Identifieur interne : 000295 ( PascalFrancis/Curation ); précédent : 000294; suivant : 000296

Injury and strain-dependent dopaminergic neuronal degeneration in the substantia nigra of mice after axotomy or MPTP

Auteurs : LI LIU [Canada] ; Shu S. Hsu [Canada] ; Suneil K. Kalia [Canada] ; Andres M. Lozano [Canada]

Source :

Brain research [ 0006-8993 ] ; 2003.

RBID : Pascal:04-0115606

Descripteurs français

Pascal (Inist)
- Dégénérescence, Locus niger, Axotomie, Pyridine(1-méthyl-4-phényl-1,2,3,6-tétrahydro), Neurotoxine, Neurone dopaminergique, Mort cellulaire, Parkinson maladie, Animal, Souris.

English descriptors

KwdEn :
- Animal, Axotomy, Cell death, Degeneration, Dopaminergic neuron, Locus niger, Mouse, Neurotoxin, Parkinson disease.

Abstract

We studied the effects of axotomy or neurotoxin on the survival of substantia nigra pars compacta (SNpc) neurons in two strains of mice, FVB/N or C57BL/6. Fluoro gold (FG) was injected into both striata of the mice to retrogradely label the nigrostriatal neuronal population. Ten days later, these neurons were axotomized in the medial forebrain bundle (MFB) unilaterally or N-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP) was administered intraperitonealy for 2 days to produce bilateral degeneration. MFB transection or MPTP administration produced a progressive loss of FG-labeled and tyrosine hydroxylase immunolabeled (TH+) neurons in both strains. Relative to control, 72% of SNpc neurons died 4 weeks after axotomy in C57BL/6 mice and 50% died after axotomy in FVB/N mice. MPTP resulted in death of 80% of SNpc neurons in C57BL/6 mice but only 40% in the FVB strain 4 weeks after MPTP administration. In this more sensitive strain, MPTP cell death was associated with positive staining for terminal deoxynucleotidyl transferase-mediated dUTP nick end labeling (TUNEL) and nuclear condensation. In contrast, no TUNEL staining was detected in SNpc after MPTP in FVB/N mice. Further, while similar kinetics and extent of cell death accompanied axotomy, axotomy-induced cell death was TUNEL negative in both FVB/N and C57BL/6 mice, Double staining for TUNEL and microtubule associated protein 2 confirmed that the majority of the TUNEL positive cells were neurons. These data indicate that genetic factors and the type of lesion play an important role in determining death of dopaminergic neurons after injury.

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A02	`01`			`@0 BRREAP`
A03		`1`		`@0 Brain res.`
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A08	`01`	`1`	`ENG`	`@1 Injury and strain-dependent dopaminergic neuronal degeneration in the substantia nigra of mice after axotomy or MPTP`
A11	`01`	`1`		`@1 LI LIU`
A11	`02`	`1`		`@1 HSU (Shu S.)`
A11	`03`	`1`		`@1 KALIA (Suneil K.)`
A11	`04`	`1`		`@1 LOZANO (Andres M.)`
A14	`01`			`@1 Division of Applied and Interventional Research, Toronto Western Hospital Research Institute, University of Toronto, 399 Bathurst Street @2 Toronto ON, M5T 2S8 @3 CAN @Z 1 aut. @Z 2 aut. @Z 3 aut. @Z 4 aut.`
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A21				`@1 2003`
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A44				`@0 0000 @1 © 2004 INIST-CNRS. All rights reserved.`
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A64	`01`	`1`		`@0 Brain research`
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C01	`01`		`ENG`	@0 We studied the effects of axotomy or neurotoxin on the survival of substantia nigra pars compacta (SNpc) neurons in two strains of mice, FVB/N or C57BL/6. Fluoro gold (FG) was injected into both striata of the mice to retrogradely label the nigrostriatal neuronal population. Ten days later, these neurons were axotomized in the medial forebrain bundle (MFB) unilaterally or N-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP) was administered intraperitonealy for 2 days to produce bilateral degeneration. MFB transection or MPTP administration produced a progressive loss of FG-labeled and tyrosine hydroxylase immunolabeled (TH+) neurons in both strains. Relative to control, 72% of SNpc neurons died 4 weeks after axotomy in C57BL/6 mice and 50% died after axotomy in FVB/N mice. MPTP resulted in death of 80% of SNpc neurons in C57BL/6 mice but only 40% in the FVB strain 4 weeks after MPTP administration. In this more sensitive strain, MPTP cell death was associated with positive staining for terminal deoxynucleotidyl transferase-mediated dUTP nick end labeling (TUNEL) and nuclear condensation. In contrast, no TUNEL staining was detected in SNpc after MPTP in FVB/N mice. Further, while similar kinetics and extent of cell death accompanied axotomy, axotomy-induced cell death was TUNEL negative in both FVB/N and C57BL/6 mice, Double staining for TUNEL and microtubule associated protein 2 confirmed that the majority of the TUNEL positive cells were neurons. These data indicate that genetic factors and the type of lesion play an important role in determining death of dopaminergic neurons after injury.
C02	`01`	`X`		`@0 002B17G`
C03	`01`	`X`	`FRE`	`@0 Dégénérescence @5 01`
C03	`01`	`X`	`ENG`	`@0 Degeneration @5 01`
C03	`01`	`X`	`SPA`	`@0 Degeneración @5 01`
C03	`02`	`X`	`FRE`	`@0 Locus niger @5 02`
C03	`02`	`X`	`ENG`	`@0 Locus niger @5 02`
C03	`02`	`X`	`SPA`	`@0 Locus níger @5 02`
C03	`03`	`X`	`FRE`	`@0 Axotomie @5 03`
C03	`03`	`X`	`ENG`	`@0 Axotomy @5 03`
C03	`03`	`X`	`SPA`	`@0 Axotomía @5 03`
C03	`04`	`X`	`FRE`	`@0 Pyridine(1-méthyl-4-phényl-1,2,3,6-tétrahydro) @2 NK @2 FX @5 04 @6 Pyridine(«1»-méthyl-«4»-phényl-«1,2,3,6»-tétrahydro)`
C03	`05`	`X`	`FRE`	`@0 Neurotoxine @5 05`
C03	`05`	`X`	`ENG`	`@0 Neurotoxin @5 05`
C03	`05`	`X`	`SPA`	`@0 Neurotoxina @5 05`
C03	`06`	`X`	`FRE`	`@0 Neurone dopaminergique @5 06`
C03	`06`	`X`	`ENG`	`@0 Dopaminergic neuron @5 06`
C03	`06`	`X`	`SPA`	`@0 Neurona dopaminérgica @5 06`
C03	`07`	`X`	`FRE`	`@0 Mort cellulaire @5 07`
C03	`07`	`X`	`ENG`	`@0 Cell death @5 07`
C03	`07`	`X`	`SPA`	`@0 Muerte celular @5 07`
C03	`08`	`X`	`FRE`	`@0 Parkinson maladie @5 09`
C03	`08`	`X`	`ENG`	`@0 Parkinson disease @5 09`
C03	`08`	`X`	`SPA`	`@0 Parkinson enfermedad @5 09`
C03	`09`	`X`	`FRE`	`@0 Animal @5 14`
C03	`09`	`X`	`ENG`	`@0 Animal @5 14`
C03	`09`	`X`	`SPA`	`@0 Animal @5 14`
C03	`10`	`X`	`FRE`	`@0 Souris @5 54`
C03	`10`	`X`	`ENG`	`@0 Mouse @5 54`
C03	`10`	`X`	`SPA`	`@0 Ratón @5 54`
C07	`01`	`X`	`FRE`	`@0 Toxine`
C07	`01`	`X`	`ENG`	`@0 Toxin`
C07	`01`	`X`	`SPA`	`@0 Toxina`
C07	`02`	`X`	`FRE`	`@0 Encéphale @5 23`
C07	`02`	`X`	`ENG`	`@0 Encephalon @5 23`
C07	`02`	`X`	`SPA`	`@0 Encéfalo @5 23`
C07	`03`	`X`	`FRE`	`@0 Système nerveux central @5 24`
C07	`03`	`X`	`ENG`	`@0 Central nervous system @5 24`
C07	`03`	`X`	`SPA`	`@0 Sistema nervioso central @5 24`
C07	`04`	`X`	`FRE`	`@0 Système nerveux pathologie @5 38`
C07	`04`	`X`	`ENG`	`@0 Nervous system diseases @5 38`
C07	`04`	`X`	`SPA`	`@0 Sistema nervioso patología @5 38`
C07	`05`	`X`	`FRE`	`@0 Système nerveux central pathologie @5 39`
C07	`05`	`X`	`ENG`	`@0 Central nervous system disease @5 39`
C07	`05`	`X`	`SPA`	`@0 Sistema nervosio central patología @5 39`
C07	`06`	`X`	`FRE`	`@0 Encéphale pathologie @5 40`
C07	`06`	`X`	`ENG`	`@0 Cerebral disorder @5 40`
C07	`06`	`X`	`SPA`	`@0 Encéfalo patología @5 40`
C07	`07`	`X`	`FRE`	`@0 Extrapyramidal syndrome @5 41`
C07	`07`	`X`	`ENG`	`@0 Extrapyramidal syndrome @5 41`
C07	`07`	`X`	`SPA`	`@0 Extrapiramidal síndrome @5 41`
C07	`08`	`X`	`FRE`	`@0 Maladie dégénérative @5 42`
C07	`08`	`X`	`ENG`	`@0 Degenerative disease @5 42`
C07	`08`	`X`	`SPA`	`@0 Enfermedad degenerativa @5 42`
C07	`09`	`X`	`FRE`	`@0 Rodentia @2 NS`
C07	`09`	`X`	`ENG`	`@0 Rodentia @2 NS`
C07	`09`	`X`	`SPA`	`@0 Rodentia @2 NS`
C07	`10`	`X`	`FRE`	`@0 Mammalia @2 NS`
C07	`10`	`X`	`ENG`	`@0 Mammalia @2 NS`
C07	`10`	`X`	`SPA`	`@0 Mammalia @2 NS`
C07	`11`	`X`	`FRE`	`@0 Vertebrata @2 NS`
C07	`11`	`X`	`ENG`	`@0 Vertebrata @2 NS`
C07	`11`	`X`	`SPA`	`@0 Vertebrata @2 NS`
N21				`@1 075`

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Le document en format XML

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<front><div type="abstract" xml:lang="en">We studied the effects of axotomy or neurotoxin on the survival of substantia nigra pars compacta (SNpc) neurons in two strains of mice, FVB/N or C57BL/6. Fluoro gold (FG) was injected into both striata of the mice to retrogradely label the nigrostriatal neuronal population. Ten days later, these neurons were axotomized in the medial forebrain bundle (MFB) unilaterally or N-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP) was administered intraperitonealy for 2 days to produce bilateral degeneration. MFB transection or MPTP administration produced a progressive loss of FG-labeled and tyrosine hydroxylase immunolabeled (TH+) neurons in both strains. Relative to control, 72% of SNpc neurons died 4 weeks after axotomy in C57BL/6 mice and 50% died after axotomy in FVB/N mice. MPTP resulted in death of 80% of SNpc neurons in C57BL/6 mice but only 40% in the FVB strain 4 weeks after MPTP administration. In this more sensitive strain, MPTP cell death was associated with positive staining for terminal deoxynucleotidyl transferase-mediated dUTP nick end labeling (TUNEL) and nuclear condensation. In contrast, no TUNEL staining was detected in SNpc after MPTP in FVB/N mice. Further, while similar kinetics and extent of cell death accompanied axotomy, axotomy-induced cell death was TUNEL negative in both FVB/N and C57BL/6 mice, Double staining for TUNEL and microtubule associated protein 2 confirmed that the majority of the TUNEL positive cells were neurons. These data indicate that genetic factors and the type of lesion play an important role in determining death of dopaminergic neurons after injury.</div>
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<fC01 i1="01" l="ENG"><s0>We studied the effects of axotomy or neurotoxin on the survival of substantia nigra pars compacta (SNpc) neurons in two strains of mice, FVB/N or C57BL/6. Fluoro gold (FG) was injected into both striata of the mice to retrogradely label the nigrostriatal neuronal population. Ten days later, these neurons were axotomized in the medial forebrain bundle (MFB) unilaterally or N-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP) was administered intraperitonealy for 2 days to produce bilateral degeneration. MFB transection or MPTP administration produced a progressive loss of FG-labeled and tyrosine hydroxylase immunolabeled (TH+) neurons in both strains. Relative to control, 72% of SNpc neurons died 4 weeks after axotomy in C57BL/6 mice and 50% died after axotomy in FVB/N mice. MPTP resulted in death of 80% of SNpc neurons in C57BL/6 mice but only 40% in the FVB strain 4 weeks after MPTP administration. In this more sensitive strain, MPTP cell death was associated with positive staining for terminal deoxynucleotidyl transferase-mediated dUTP nick end labeling (TUNEL) and nuclear condensation. In contrast, no TUNEL staining was detected in SNpc after MPTP in FVB/N mice. Further, while similar kinetics and extent of cell death accompanied axotomy, axotomy-induced cell death was TUNEL negative in both FVB/N and C57BL/6 mice, Double staining for TUNEL and microtubule associated protein 2 confirmed that the majority of the TUNEL positive cells were neurons. These data indicate that genetic factors and the type of lesion play an important role in determining death of dopaminergic neurons after injury.</s0>
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<s5>03</s5>
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<fC03 i1="03" i2="X" l="ENG"><s0>Axotomy</s0>
<s5>03</s5>
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<fC03 i1="03" i2="X" l="SPA"><s0>Axotomía</s0>
<s5>03</s5>
</fC03>
<fC03 i1="04" i2="X" l="FRE"><s0>Pyridine(1-méthyl-4-phényl-1,2,3,6-tétrahydro)</s0>
<s2>NK</s2>
<s2>FX</s2>
<s5>04</s5>
<s6>Pyridine(«1»-méthyl-«4»-phényl-«1,2,3,6»-tétrahydro)</s6>
</fC03>
<fC03 i1="05" i2="X" l="FRE"><s0>Neurotoxine</s0>
<s5>05</s5>
</fC03>
<fC03 i1="05" i2="X" l="ENG"><s0>Neurotoxin</s0>
<s5>05</s5>
</fC03>
<fC03 i1="05" i2="X" l="SPA"><s0>Neurotoxina</s0>
<s5>05</s5>
</fC03>
<fC03 i1="06" i2="X" l="FRE"><s0>Neurone dopaminergique</s0>
<s5>06</s5>
</fC03>
<fC03 i1="06" i2="X" l="ENG"><s0>Dopaminergic neuron</s0>
<s5>06</s5>
</fC03>
<fC03 i1="06" i2="X" l="SPA"><s0>Neurona dopaminérgica</s0>
<s5>06</s5>
</fC03>
<fC03 i1="07" i2="X" l="FRE"><s0>Mort cellulaire</s0>
<s5>07</s5>
</fC03>
<fC03 i1="07" i2="X" l="ENG"><s0>Cell death</s0>
<s5>07</s5>
</fC03>
<fC03 i1="07" i2="X" l="SPA"><s0>Muerte celular</s0>
<s5>07</s5>
</fC03>
<fC03 i1="08" i2="X" l="FRE"><s0>Parkinson maladie</s0>
<s5>09</s5>
</fC03>
<fC03 i1="08" i2="X" l="ENG"><s0>Parkinson disease</s0>
<s5>09</s5>
</fC03>
<fC03 i1="08" i2="X" l="SPA"><s0>Parkinson enfermedad</s0>
<s5>09</s5>
</fC03>
<fC03 i1="09" i2="X" l="FRE"><s0>Animal</s0>
<s5>14</s5>
</fC03>
<fC03 i1="09" i2="X" l="ENG"><s0>Animal</s0>
<s5>14</s5>
</fC03>
<fC03 i1="09" i2="X" l="SPA"><s0>Animal</s0>
<s5>14</s5>
</fC03>
<fC03 i1="10" i2="X" l="FRE"><s0>Souris</s0>
<s5>54</s5>
</fC03>
<fC03 i1="10" i2="X" l="ENG"><s0>Mouse</s0>
<s5>54</s5>
</fC03>
<fC03 i1="10" i2="X" l="SPA"><s0>Ratón</s0>
<s5>54</s5>
</fC03>
<fC07 i1="01" i2="X" l="FRE"><s0>Toxine</s0>
</fC07>
<fC07 i1="01" i2="X" l="ENG"><s0>Toxin</s0>
</fC07>
<fC07 i1="01" i2="X" l="SPA"><s0>Toxina</s0>
</fC07>
<fC07 i1="02" i2="X" l="FRE"><s0>Encéphale</s0>
<s5>23</s5>
</fC07>
<fC07 i1="02" i2="X" l="ENG"><s0>Encephalon</s0>
<s5>23</s5>
</fC07>
<fC07 i1="02" i2="X" l="SPA"><s0>Encéfalo</s0>
<s5>23</s5>
</fC07>
<fC07 i1="03" i2="X" l="FRE"><s0>Système nerveux central</s0>
<s5>24</s5>
</fC07>
<fC07 i1="03" i2="X" l="ENG"><s0>Central nervous system</s0>
<s5>24</s5>
</fC07>
<fC07 i1="03" i2="X" l="SPA"><s0>Sistema nervioso central</s0>
<s5>24</s5>
</fC07>
<fC07 i1="04" i2="X" l="FRE"><s0>Système nerveux pathologie</s0>
<s5>38</s5>
</fC07>
<fC07 i1="04" i2="X" l="ENG"><s0>Nervous system diseases</s0>
<s5>38</s5>
</fC07>
<fC07 i1="04" i2="X" l="SPA"><s0>Sistema nervioso patología</s0>
<s5>38</s5>
</fC07>
<fC07 i1="05" i2="X" l="FRE"><s0>Système nerveux central pathologie</s0>
<s5>39</s5>
</fC07>
<fC07 i1="05" i2="X" l="ENG"><s0>Central nervous system disease</s0>
<s5>39</s5>
</fC07>
<fC07 i1="05" i2="X" l="SPA"><s0>Sistema nervosio central patología</s0>
<s5>39</s5>
</fC07>
<fC07 i1="06" i2="X" l="FRE"><s0>Encéphale pathologie</s0>
<s5>40</s5>
</fC07>
<fC07 i1="06" i2="X" l="ENG"><s0>Cerebral disorder</s0>
<s5>40</s5>
</fC07>
<fC07 i1="06" i2="X" l="SPA"><s0>Encéfalo patología</s0>
<s5>40</s5>
</fC07>
<fC07 i1="07" i2="X" l="FRE"><s0>Extrapyramidal syndrome</s0>
<s5>41</s5>
</fC07>
<fC07 i1="07" i2="X" l="ENG"><s0>Extrapyramidal syndrome</s0>
<s5>41</s5>
</fC07>
<fC07 i1="07" i2="X" l="SPA"><s0>Extrapiramidal síndrome</s0>
<s5>41</s5>
</fC07>
<fC07 i1="08" i2="X" l="FRE"><s0>Maladie dégénérative</s0>
<s5>42</s5>
</fC07>
<fC07 i1="08" i2="X" l="ENG"><s0>Degenerative disease</s0>
<s5>42</s5>
</fC07>
<fC07 i1="08" i2="X" l="SPA"><s0>Enfermedad degenerativa</s0>
<s5>42</s5>
</fC07>
<fC07 i1="09" i2="X" l="FRE"><s0>Rodentia</s0>
<s2>NS</s2>
</fC07>
<fC07 i1="09" i2="X" l="ENG"><s0>Rodentia</s0>
<s2>NS</s2>
</fC07>
<fC07 i1="09" i2="X" l="SPA"><s0>Rodentia</s0>
<s2>NS</s2>
</fC07>
<fC07 i1="10" i2="X" l="FRE"><s0>Mammalia</s0>
<s2>NS</s2>
</fC07>
<fC07 i1="10" i2="X" l="ENG"><s0>Mammalia</s0>
<s2>NS</s2>
</fC07>
<fC07 i1="10" i2="X" l="SPA"><s0>Mammalia</s0>
<s2>NS</s2>
</fC07>
<fC07 i1="11" i2="X" l="FRE"><s0>Vertebrata</s0>
<s2>NS</s2>
</fC07>
<fC07 i1="11" i2="X" l="ENG"><s0>Vertebrata</s0>
<s2>NS</s2>
</fC07>
<fC07 i1="11" i2="X" l="SPA"><s0>Vertebrata</s0>
<s2>NS</s2>
</fC07>
<fN21><s1>075</s1>
</fN21>
</pA>
</standard>
</inist>
</record>

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	La maladie de Parkinson au Canada (serveur d'exploration)
	Attention, ce site est en cours de développement ! Attention, site généré par des moyens informatiques à partir de corpus bruts. Les informations ne sont donc pas validées.

La maladie de Parkinson au Canada (serveur d'exploration)

Injury and strain-dependent dopaminergic neuronal degeneration in the substantia nigra of mice after axotomy or MPTP

Injury and strain-dependent dopaminergic neuronal degeneration in the substantia nigra of mice after axotomy or MPTP

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