Manganese, monoamine metabolite levels at birth, and child psychomotor development
Identifieur interne : 000275 ( PascalFrancis/Curation ); précédent : 000274; suivant : 000276Manganese, monoamine metabolite levels at birth, and child psychomotor development
Auteurs : Larissa Takser [France] ; Donna Mergler [Canada] ; Georgette Hellier [France] ; Josiane Sahuquillo [France] ; Guy Huel [France]Source :
- Neurotoxicology : (Park Forest South) [ 0161-813X ] ; 2003.
Descripteurs français
- Pascal (Inist)
- Wicri :
- topic : Manganèse, Métal lourd, Homme, Enfant.
English descriptors
- KwdEn :
Abstract
Several studies have demonstrated neurobehavioral impairment related to manganese (Mn) exposure in the workplace. Exposure to high doses of manganese is associated with irreversible neurodegenerative disorders resembling idiopathic Parkinson disease. Although there is a risk of Mn accumulation in the foetus during pregnancy, little information exists about developmental effects of environmental low-level exposure in human. For this reason, we conducted a prospective epidemiological study in 247 healthy pregnant women and their babies to determine the long-term effect of in utero Mn levels on child's psychomotor development. Concurrently, we examined the relationship between Mn tissue levels at delivery and foetal plasma monoamine metabolites. Of the newborns, 195 were examined at 9 months, 126 at 3 years and 100 at 6 years. At 9 months, the Brunet-Lézine scales were administered. The McCarthy scales of children's abilities were used at 3 and 6 years. After adjustment for potential confounding co-factors (child's gender, mother's educational level), negative relationships were observed between cord blood Mn levels and several psychomotor sub-scales at age of 3 years: attention (partial r = -0.33, P < 0.001), non-verbal memory (partial r = -0.28, P < 0.01 ), and hand skills (partial r = -0.22, P < 0.05), No significant relationships were observed between Mn measures at birth and the general psychomotor indices, Brunet-Lézine developmental quotient (DQ) at 9 months or McCarthy general cognitive index (GCI) at 3 and 6 years. Maternal blood Mn levels were negatively associated with foetal plasma HVA and 5-HIAA concentrations (adjusted for labour duration, child's gender, and smoking during pregnancy), but the adjustment for monoamine levels at birth did not change the association between the Mn levels and the psychomotor scores. These results suggest that environmental Mn exposure in utero could affect early psychomotor development.
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aut.</sZ></inist:fA14><country>Canada</country></affiliation></author><author><name sortKey="Hellier, Georgette" sort="Hellier, Georgette" uniqKey="Hellier G" first="Georgette" last="Hellier">Georgette Hellier</name><affiliation wicri:level="1"><inist:fA14 i1="01"><s1>Institut National de la Santé et de la Recherche Médicale (INSERM-U472), Recherche en Épidemiologie et en Biostatistique, 16 Avenue Paul-Vaillant Couturier</s1><s2>94807 Villejuif</s2><s3>FRA</s3><sZ>1 aut.</sZ><sZ>3 aut.</sZ><sZ>4 aut.</sZ><sZ>5 aut.</sZ></inist:fA14><country>France</country></affiliation></author><author><name sortKey="Sahuquillo, Josiane" sort="Sahuquillo, Josiane" uniqKey="Sahuquillo J" first="Josiane" last="Sahuquillo">Josiane Sahuquillo</name><affiliation wicri:level="1"><inist:fA14 i1="01"><s1>Institut National de la Santé et de la Recherche Médicale (INSERM-U472), Recherche en Épidemiologie et en Biostatistique, 16 Avenue Paul-Vaillant Couturier</s1><s2>94807 Villejuif</s2><s3>FRA</s3><sZ>1 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xml:lang="en" level="a">Manganese, monoamine metabolite levels at birth, and child psychomotor development</title><author><name sortKey="Takser, Larissa" sort="Takser, Larissa" uniqKey="Takser L" first="Larissa" last="Takser">Larissa Takser</name><affiliation wicri:level="1"><inist:fA14 i1="01"><s1>Institut National de la Santé et de la Recherche Médicale (INSERM-U472), Recherche en Épidemiologie et en Biostatistique, 16 Avenue Paul-Vaillant Couturier</s1><s2>94807 Villejuif</s2><s3>FRA</s3><sZ>1 aut.</sZ><sZ>3 aut.</sZ><sZ>4 aut.</sZ><sZ>5 aut.</sZ></inist:fA14><country>France</country></affiliation></author><author><name sortKey="Mergler, Donna" sort="Mergler, Donna" uniqKey="Mergler D" first="Donna" last="Mergler">Donna Mergler</name><affiliation wicri:level="1"><inist:fA14 i1="02"><s1>CINBIOSE, Université du Québec à Montréal</s1><s2>Montréal, Que.</s2><s3>CAN</s3><sZ>2 aut.</sZ></inist:fA14><country>Canada</country></affiliation></author><author><name sortKey="Hellier, Georgette" sort="Hellier, Georgette" uniqKey="Hellier G" first="Georgette" last="Hellier">Georgette Hellier</name><affiliation wicri:level="1"><inist:fA14 i1="01"><s1>Institut National de la Santé et de la Recherche Médicale (INSERM-U472), Recherche en Épidemiologie et en Biostatistique, 16 Avenue Paul-Vaillant Couturier</s1><s2>94807 Villejuif</s2><s3>FRA</s3><sZ>1 aut.</sZ><sZ>3 aut.</sZ><sZ>4 aut.</sZ><sZ>5 aut.</sZ></inist:fA14><country>France</country></affiliation></author><author><name sortKey="Sahuquillo, Josiane" sort="Sahuquillo, Josiane" uniqKey="Sahuquillo J" first="Josiane" last="Sahuquillo">Josiane Sahuquillo</name><affiliation wicri:level="1"><inist:fA14 i1="01"><s1>Institut National de la Santé et de la Recherche Médicale (INSERM-U472), Recherche en Épidemiologie et en Biostatistique, 16 Avenue Paul-Vaillant Couturier</s1><s2>94807 Villejuif</s2><s3>FRA</s3><sZ>1 aut.</sZ><sZ>3 aut.</sZ><sZ>4 aut.</sZ><sZ>5 aut.</sZ></inist:fA14><country>France</country></affiliation></author><author><name sortKey="Huel, Guy" sort="Huel, Guy" uniqKey="Huel G" first="Guy" last="Huel">Guy Huel</name><affiliation wicri:level="1"><inist:fA14 i1="01"><s1>Institut National de la Santé et de la Recherche Médicale (INSERM-U472), Recherche en Épidemiologie et en Biostatistique, 16 Avenue Paul-Vaillant Couturier</s1><s2>94807 Villejuif</s2><s3>FRA</s3><sZ>1 aut.</sZ><sZ>3 aut.</sZ><sZ>4 aut.</sZ><sZ>5 aut.</sZ></inist:fA14><country>France</country></affiliation></author></analytic><series><title level="j" type="main">Neurotoxicology : (Park Forest South)</title><title level="j" type="abbreviated">Neurotoxicology : (Park Forest South)</title><idno type="ISSN">0161-813X</idno><imprint><date when="2003">2003</date></imprint></series></biblStruct></sourceDesc><seriesStmt><title level="j" type="main">Neurotoxicology : (Park Forest South)</title><title level="j" type="abbreviated">Neurotoxicology : (Park Forest South)</title><idno type="ISSN">0161-813X</idno></seriesStmt></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Child</term><term>Dopamine</term><term>Heavy metal</term><term>Human</term><term>Low dose</term><term>Manganese</term><term>Pregnancy</term><term>Progeny</term><term>Psychomotor development</term><term>Serotonin</term><term>Toxicity</term></keywords><keywords scheme="Pascal" xml:lang="fr"><term>Manganèse</term><term>Métal lourd</term><term>Toxicité</term><term>Dose faible</term><term>Gestation</term><term>Descendance</term><term>Homme</term><term>Développement psychomoteur</term><term>Enfant</term><term>Dopamine</term><term>Sérotonine</term></keywords><keywords scheme="Wicri" type="topic" xml:lang="fr"><term>Manganèse</term><term>Métal lourd</term><term>Homme</term><term>Enfant</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">Several studies have demonstrated neurobehavioral impairment related to manganese (Mn) exposure in the workplace. Exposure to high doses of manganese is associated with irreversible neurodegenerative disorders resembling idiopathic Parkinson disease. Although there is a risk of Mn accumulation in the foetus during pregnancy, little information exists about developmental effects of environmental low-level exposure in human. For this reason, we conducted a prospective epidemiological study in 247 healthy pregnant women and their babies to determine the long-term effect of in utero Mn levels on child's psychomotor development. Concurrently, we examined the relationship between Mn tissue levels at delivery and foetal plasma monoamine metabolites. Of the newborns, 195 were examined at 9 months, 126 at 3 years and 100 at 6 years. At 9 months, the Brunet-Lézine scales were administered. The McCarthy scales of children's abilities were used at 3 and 6 years. After adjustment for potential confounding co-factors (child's gender, mother's educational level), negative relationships were observed between cord blood Mn levels and several psychomotor sub-scales at age of 3 years: attention (partial r = -0.33, P < 0.001), non-verbal memory (partial r = -0.28, P < 0.01 ), and hand skills (partial r = -0.22, P < 0.05), No significant relationships were observed between Mn measures at birth and the general psychomotor indices, Brunet-Lézine developmental quotient (DQ) at 9 months or McCarthy general cognitive index (GCI) at 3 and 6 years. Maternal blood Mn levels were negatively associated with foetal plasma HVA and 5-HIAA concentrations (adjusted for labour duration, child's gender, and smoking during pregnancy), but the adjustment for monoamine levels at birth did not change the association between the Mn levels and the psychomotor scores. These results suggest that environmental Mn exposure in utero could affect early psychomotor development.</div></front></TEI><inist><standard h6="B"><pA><fA01 i1="01" i2="1"><s0>0161-813X</s0></fA01><fA03 i2="1"><s0>Neurotoxicology : (Park Forest South)</s0></fA03><fA05><s2>24</s2></fA05><fA06><s2>4-5</s2></fA06><fA08 i1="01" i2="1" l="ENG"><s1>Manganese, monoamine metabolite levels at birth, and child psychomotor development</s1></fA08><fA11 i1="01" i2="1"><s1>TAKSER (Larissa)</s1></fA11><fA11 i1="02" i2="1"><s1>MERGLER (Donna)</s1></fA11><fA11 i1="03" i2="1"><s1>HELLIER (Georgette)</s1></fA11><fA11 i1="04" i2="1"><s1>SAHUQUILLO (Josiane)</s1></fA11><fA11 i1="05" i2="1"><s1>HUEL (Guy)</s1></fA11><fA14 i1="01"><s1>Institut National de la Santé et de la Recherche Médicale (INSERM-U472), Recherche en Épidemiologie et en Biostatistique, 16 Avenue Paul-Vaillant Couturier</s1><s2>94807 Villejuif</s2><s3>FRA</s3><sZ>1 aut.</sZ><sZ>3 aut.</sZ><sZ>4 aut.</sZ><sZ>5 aut.</sZ></fA14><fA14 i1="02"><s1>CINBIOSE, Université du Québec à Montréal</s1><s2>Montréal, Que.</s2><s3>CAN</s3><sZ>2 aut.</sZ></fA14><fA20><s1>667-674</s1></fA20><fA21><s1>2003</s1></fA21><fA23 i1="01"><s0>ENG</s0></fA23><fA43 i1="01"><s1>INIST</s1><s2>18397</s2><s5>354000112711200200</s5></fA43><fA44><s0>0000</s0><s1>© 2003 INIST-CNRS. All rights reserved.</s1></fA44><fA45><s0>1 p.1/4</s0></fA45><fA47 i1="01" i2="1"><s0>03-0433727</s0></fA47><fA60><s1>P</s1></fA60><fA61><s0>A</s0></fA61><fA64 i1="01" i2="1"><s0>Neurotoxicology : (Park Forest South)</s0></fA64><fA66 i1="01"><s0>USA</s0></fA66><fC01 i1="01" l="ENG"><s0>Several studies have demonstrated neurobehavioral impairment related to manganese (Mn) exposure in the workplace. Exposure to high doses of manganese is associated with irreversible neurodegenerative disorders resembling idiopathic Parkinson disease. Although there is a risk of Mn accumulation in the foetus during pregnancy, little information exists about developmental effects of environmental low-level exposure in human. For this reason, we conducted a prospective epidemiological study in 247 healthy pregnant women and their babies to determine the long-term effect of in utero Mn levels on child's psychomotor development. Concurrently, we examined the relationship between Mn tissue levels at delivery and foetal plasma monoamine metabolites. Of the newborns, 195 were examined at 9 months, 126 at 3 years and 100 at 6 years. At 9 months, the Brunet-Lézine scales were administered. The McCarthy scales of children's abilities were used at 3 and 6 years. After adjustment for potential confounding co-factors (child's gender, mother's educational level), negative relationships were observed between cord blood Mn levels and several psychomotor sub-scales at age of 3 years: attention (partial r = -0.33, P < 0.001), non-verbal memory (partial r = -0.28, P < 0.01 ), and hand skills (partial r = -0.22, P < 0.05), No significant relationships were observed between Mn measures at birth and the general psychomotor indices, Brunet-Lézine developmental quotient (DQ) at 9 months or McCarthy general cognitive index (GCI) at 3 and 6 years. Maternal blood Mn levels were negatively associated with foetal plasma HVA and 5-HIAA concentrations (adjusted for labour duration, child's gender, and smoking during pregnancy), but the adjustment for monoamine levels at birth did not change the association between the Mn levels and the psychomotor scores. 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