ParkinsonCanadaV1, PascalFrancis, Curation, bibRecord, 000050

Long term outcome of unilateral pallidotomy : Follow up of 15 patients for 3 years

Identifieur interne : 000050 ( PascalFrancis/Curation ); précédent : 000049; suivant : 000051

Long term outcome of unilateral pallidotomy : Follow up of 15 patients for 3 years

Auteurs : P. K. Pal [Canada] ; A. Samii [Canada] ; A. Kishore [Canada] ; M. Schulzer [Canada] ; E. Mak [Canada] ; S. Yardley [Canada] ; I. M. Turnbull [Canada] ; D. B. Calne [Canada]

Source :

Journal of neurology, neurosurgery and psychiatry [ 0022-3050 ] ; 2000.

RBID : Pascal:00-0430182

Descripteurs français

Pascal (Inist)
- Parkinson maladie, Chirurgie stéréotaxique, Pallidum, Long terme, Traitement, Evolution, Homme, Unilatéral, Efficacité traitement.
Wicri :
- topic : Homme.

English descriptors

KwdEn :
- Evolution, Human, Long term, Pallidum, Parkinson disease, Stereotaxic surgery, Treatment, Treatment efficiency, Unilateral.

Abstract

Objectives-With the advent of new antiparkinsonian drug therapy and promising results from subthalamic and pallidal stimulation, this study evaluated the long term efficacy of unilateral pallidotomy, a technique which has gained popularity over the past decade for the management of advanced Parkinson's disease. Methods-The 15 patients reported here are part of the original cohort of 24 patients who underwent posteroventral pallidotomy for motor fluctuations and disabling dyskinesias 3 years ago as part of a prospective study. Evaluation scales included the unified Parkinson's disease rating scale, the Goetz dyskinesia scale, and the Purdue pegboard test. Results-When compared with the prepallidotomy scores, the reduction in the limb dyskinesias and off state tremor scores persisted on the side contralateral to pallidotomy at the end of 3 years (dyskinesias were reduced by 64% (p<0.01) and tremor by 63% (p<0.05). Other measures tended to deteriorate. The dosage of antiparkinsonian medications did not change significantly from 3 months prepallidotomy to 3 years postpallidotomy. Conclusions-Although unilateral pallidotomy is useful in controlling the contralateral dyskinesias and tremor 3 years after surgery, all other early benefits disappear and activities of daily living continue to worsen.

A01	`01`	`1`		`@0 0022-3050`
A02	`01`			`@0 JNNPAU`
A03		`1`		`@0 J. neurol. neurosurg. psychiatry`
A05				`@2 69`
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A08	`01`	`1`	`ENG`	`@1 Long term outcome of unilateral pallidotomy : Follow up of 15 patients for 3 years`
A11	`01`	`1`		`@1 PAL (P. K.)`
A11	`02`	`1`		`@1 SAMII (A.)`
A11	`03`	`1`		`@1 KISHORE (A.)`
A11	`04`	`1`		`@1 SCHULZER (M.)`
A11	`05`	`1`		`@1 MAK (E.)`
A11	`06`	`1`		`@1 YARDLEY (S.)`
A11	`07`	`1`		`@1 TURNBULL (I. M.)`
A11	`08`	`1`		`@1 CALNE (D. B.)`
A14	`01`			`@1 Neurodegenerative Disorders Centre, M 36 Purdy Pavilion, Vancouver Hospital and Health Sciences Centre, 2221 Wesbrook Mall @2 Vancouver, BC, V6T 2B5 @3 CAN @Z 1 aut. @Z 2 aut. @Z 3 aut. @Z 4 aut. @Z 5 aut. @Z 6 aut. @Z 7 aut. @Z 8 aut.`
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A21				`@1 2000`
A23	`01`			`@0 ENG`
A43	`01`			`@1 INIST @2 6015 @5 354000091463910110`
A44				`@0 0000 @1 © 2000 INIST-CNRS. All rights reserved.`
A45				`@0 41 ref.`
A47	`01`	`1`		`@0 00-0430182`
A60				`@1 P`
A61				`@0 A`
A64	`01`	`1`		`@0 Journal of neurology, neurosurgery and psychiatry`
A66	`01`			`@0 GBR`
C01	`01`		`ENG`	@0 Objectives-With the advent of new antiparkinsonian drug therapy and promising results from subthalamic and pallidal stimulation, this study evaluated the long term efficacy of unilateral pallidotomy, a technique which has gained popularity over the past decade for the management of advanced Parkinson's disease. Methods-The 15 patients reported here are part of the original cohort of 24 patients who underwent posteroventral pallidotomy for motor fluctuations and disabling dyskinesias 3 years ago as part of a prospective study. Evaluation scales included the unified Parkinson's disease rating scale, the Goetz dyskinesia scale, and the Purdue pegboard test. Results-When compared with the prepallidotomy scores, the reduction in the limb dyskinesias and off state tremor scores persisted on the side contralateral to pallidotomy at the end of 3 years (dyskinesias were reduced by 64% (p<0.01) and tremor by 63% (p<0.05). Other measures tended to deteriorate. The dosage of antiparkinsonian medications did not change significantly from 3 months prepallidotomy to 3 years postpallidotomy. Conclusions-Although unilateral pallidotomy is useful in controlling the contralateral dyskinesias and tremor 3 years after surgery, all other early benefits disappear and activities of daily living continue to worsen.
C02	`01`	`X`		`@0 002B17G`
C03	`01`	`X`	`FRE`	`@0 Parkinson maladie @5 01`
C03	`01`	`X`	`ENG`	`@0 Parkinson disease @5 01`
C03	`01`	`X`	`SPA`	`@0 Parkinson enfermedad @5 01`
C03	`02`	`X`	`FRE`	`@0 Chirurgie stéréotaxique @5 04`
C03	`02`	`X`	`ENG`	`@0 Stereotaxic surgery @5 04`
C03	`02`	`X`	`SPA`	`@0 Cirugía estereotáxica @5 04`
C03	`03`	`X`	`FRE`	`@0 Pallidum @5 07`
C03	`03`	`X`	`ENG`	`@0 Pallidum @5 07`
C03	`03`	`X`	`SPA`	`@0 Pallidum @5 07`
C03	`04`	`X`	`FRE`	`@0 Long terme @5 16`
C03	`04`	`X`	`ENG`	`@0 Long term @5 16`
C03	`04`	`X`	`SPA`	`@0 Largo plazo @5 16`
C03	`05`	`X`	`FRE`	`@0 Traitement @5 17`
C03	`05`	`X`	`ENG`	`@0 Treatment @5 17`
C03	`05`	`X`	`SPA`	`@0 Tratamiento @5 17`
C03	`06`	`X`	`FRE`	`@0 Evolution @5 18`
C03	`06`	`X`	`ENG`	`@0 Evolution @5 18`
C03	`06`	`X`	`SPA`	`@0 Evolución @5 18`
C03	`07`	`X`	`FRE`	`@0 Homme @5 20`
C03	`07`	`X`	`ENG`	`@0 Human @5 20`
C03	`07`	`X`	`SPA`	`@0 Hombre @5 20`
C03	`08`	`X`	`FRE`	`@0 Unilatéral @5 23`
C03	`08`	`X`	`ENG`	`@0 Unilateral @5 23`
C03	`08`	`X`	`SPA`	`@0 Unilateral @5 23`
C03	`09`	`X`	`FRE`	`@0 Efficacité traitement @5 24`
C03	`09`	`X`	`ENG`	`@0 Treatment efficiency @5 24`
C03	`09`	`X`	`SPA`	`@0 Eficacia tratamiento @5 24`
C07	`01`	`X`	`FRE`	`@0 Système nerveux pathologie @5 37`
C07	`01`	`X`	`ENG`	`@0 Nervous system diseases @5 37`
C07	`01`	`X`	`SPA`	`@0 Sistema nervioso patología @5 37`
C07	`02`	`X`	`FRE`	`@0 Système nerveux central pathologie @5 38`
C07	`02`	`X`	`ENG`	`@0 Central nervous system disease @5 38`
C07	`02`	`X`	`SPA`	`@0 Sistema nervosio central patología @5 38`
C07	`03`	`X`	`FRE`	`@0 Encéphale pathologie @5 39`
C07	`03`	`X`	`ENG`	`@0 Cerebral disorder @5 39`
C07	`03`	`X`	`SPA`	`@0 Encéfalo patología @5 39`
C07	`04`	`X`	`FRE`	`@0 Extrapyramidal syndrome @5 40`
C07	`04`	`X`	`ENG`	`@0 Extrapyramidal syndrome @5 40`
C07	`04`	`X`	`SPA`	`@0 Extrapiramidal síndrome @5 40`
C07	`05`	`X`	`FRE`	`@0 Maladie dégénérative @5 41`
C07	`05`	`X`	`ENG`	`@0 Degenerative disease @5 41`
C07	`05`	`X`	`SPA`	`@0 Enfermedad degenerativa @5 41`
C07	`06`	`X`	`FRE`	`@0 Chirurgie @5 45`
C07	`06`	`X`	`ENG`	`@0 Surgery @5 45`
C07	`06`	`X`	`SPA`	`@0 Cirugía @5 45`
N21				`@1 290`

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Le document en format XML

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<author><name sortKey="Yardley, S" sort="Yardley, S" uniqKey="Yardley S" first="S." last="Yardley">S. Yardley</name>
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<author><name sortKey="Turnbull, I M" sort="Turnbull, I M" uniqKey="Turnbull I" first="I. M." last="Turnbull">I. M. Turnbull</name>
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<series><title level="j" type="main">Journal of neurology, neurosurgery and psychiatry</title>
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<profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Evolution</term>
<term>Human</term>
<term>Long term</term>
<term>Pallidum</term>
<term>Parkinson disease</term>
<term>Stereotaxic surgery</term>
<term>Treatment</term>
<term>Treatment efficiency</term>
<term>Unilateral</term>
</keywords>
<keywords scheme="Pascal" xml:lang="fr"><term>Parkinson maladie</term>
<term>Chirurgie stéréotaxique</term>
<term>Pallidum</term>
<term>Long terme</term>
<term>Traitement</term>
<term>Evolution</term>
<term>Homme</term>
<term>Unilatéral</term>
<term>Efficacité traitement</term>
</keywords>
<keywords scheme="Wicri" type="topic" xml:lang="fr"><term>Homme</term>
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<front><div type="abstract" xml:lang="en">Objectives-With the advent of new antiparkinsonian drug therapy and promising results from subthalamic and pallidal stimulation, this study evaluated the long term efficacy of unilateral pallidotomy, a technique which has gained popularity over the past decade for the management of advanced Parkinson's disease. Methods-The 15 patients reported here are part of the original cohort of 24 patients who underwent posteroventral pallidotomy for motor fluctuations and disabling dyskinesias 3 years ago as part of a prospective study. Evaluation scales included the unified Parkinson's disease rating scale, the Goetz dyskinesia scale, and the Purdue pegboard test. Results-When compared with the prepallidotomy scores, the reduction in the limb dyskinesias and off state tremor scores persisted on the side contralateral to pallidotomy at the end of 3 years (dyskinesias were reduced by 64% (p<0.01) and tremor by 63% (p<0.05). Other measures tended to deteriorate. The dosage of antiparkinsonian medications did not change significantly from 3 months prepallidotomy to 3 years postpallidotomy. Conclusions-Although unilateral pallidotomy is useful in controlling the contralateral dyskinesias and tremor 3 years after surgery, all other early benefits disappear and activities of daily living continue to worsen.</div>
</front>
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<inist><standard h6="B"><pA><fA01 i1="01" i2="1"><s0>0022-3050</s0>
</fA01>
<fA02 i1="01"><s0>JNNPAU</s0>
</fA02>
<fA03 i2="1"><s0>J. neurol. neurosurg. psychiatry</s0>
</fA03>
<fA05><s2>69</s2>
</fA05>
<fA06><s2>3</s2>
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<fA08 i1="01" i2="1" l="ENG"><s1>Long term outcome of unilateral pallidotomy : Follow up of 15 patients for 3 years</s1>
</fA08>
<fA11 i1="01" i2="1"><s1>PAL (P. K.)</s1>
</fA11>
<fA11 i1="02" i2="1"><s1>SAMII (A.)</s1>
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<fA11 i1="03" i2="1"><s1>KISHORE (A.)</s1>
</fA11>
<fA11 i1="04" i2="1"><s1>SCHULZER (M.)</s1>
</fA11>
<fA11 i1="05" i2="1"><s1>MAK (E.)</s1>
</fA11>
<fA11 i1="06" i2="1"><s1>YARDLEY (S.)</s1>
</fA11>
<fA11 i1="07" i2="1"><s1>TURNBULL (I. M.)</s1>
</fA11>
<fA11 i1="08" i2="1"><s1>CALNE (D. B.)</s1>
</fA11>
<fA14 i1="01"><s1>Neurodegenerative Disorders Centre, M 36 Purdy Pavilion, Vancouver Hospital and Health Sciences Centre, 2221 Wesbrook Mall</s1>
<s2>Vancouver, BC, V6T 2B5</s2>
<s3>CAN</s3>
<sZ>1 aut.</sZ>
<sZ>2 aut.</sZ>
<sZ>3 aut.</sZ>
<sZ>4 aut.</sZ>
<sZ>5 aut.</sZ>
<sZ>6 aut.</sZ>
<sZ>7 aut.</sZ>
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<fA20><s1>337-344</s1>
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<fA21><s1>2000</s1>
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<fA45><s0>41 ref.</s0>
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<fA47 i1="01" i2="1"><s0>00-0430182</s0>
</fA47>
<fA60><s1>P</s1>
</fA60>
<fA61><s0>A</s0>
</fA61>
<fA64 i1="01" i2="1"><s0>Journal of neurology, neurosurgery and psychiatry</s0>
</fA64>
<fA66 i1="01"><s0>GBR</s0>
</fA66>
<fC01 i1="01" l="ENG"><s0>Objectives-With the advent of new antiparkinsonian drug therapy and promising results from subthalamic and pallidal stimulation, this study evaluated the long term efficacy of unilateral pallidotomy, a technique which has gained popularity over the past decade for the management of advanced Parkinson's disease. Methods-The 15 patients reported here are part of the original cohort of 24 patients who underwent posteroventral pallidotomy for motor fluctuations and disabling dyskinesias 3 years ago as part of a prospective study. Evaluation scales included the unified Parkinson's disease rating scale, the Goetz dyskinesia scale, and the Purdue pegboard test. Results-When compared with the prepallidotomy scores, the reduction in the limb dyskinesias and off state tremor scores persisted on the side contralateral to pallidotomy at the end of 3 years (dyskinesias were reduced by 64% (p<0.01) and tremor by 63% (p<0.05). Other measures tended to deteriorate. The dosage of antiparkinsonian medications did not change significantly from 3 months prepallidotomy to 3 years postpallidotomy. Conclusions-Although unilateral pallidotomy is useful in controlling the contralateral dyskinesias and tremor 3 years after surgery, all other early benefits disappear and activities of daily living continue to worsen.</s0>
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<fC02 i1="01" i2="X"><s0>002B17G</s0>
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<fC03 i1="01" i2="X" l="FRE"><s0>Parkinson maladie</s0>
<s5>01</s5>
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<fC03 i1="01" i2="X" l="ENG"><s0>Parkinson disease</s0>
<s5>01</s5>
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<fC03 i1="01" i2="X" l="SPA"><s0>Parkinson enfermedad</s0>
<s5>01</s5>
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<s5>04</s5>
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<fC03 i1="02" i2="X" l="SPA"><s0>Cirugía estereotáxica</s0>
<s5>04</s5>
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<fC03 i1="03" i2="X" l="ENG"><s0>Pallidum</s0>
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<fC03 i1="03" i2="X" l="SPA"><s0>Pallidum</s0>
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<fC03 i1="04" i2="X" l="FRE"><s0>Long terme</s0>
<s5>16</s5>
</fC03>
<fC03 i1="04" i2="X" l="ENG"><s0>Long term</s0>
<s5>16</s5>
</fC03>
<fC03 i1="04" i2="X" l="SPA"><s0>Largo plazo</s0>
<s5>16</s5>
</fC03>
<fC03 i1="05" i2="X" l="FRE"><s0>Traitement</s0>
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<s5>20</s5>
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<fC03 i1="07" i2="X" l="ENG"><s0>Human</s0>
<s5>20</s5>
</fC03>
<fC03 i1="07" i2="X" l="SPA"><s0>Hombre</s0>
<s5>20</s5>
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<fC03 i1="08" i2="X" l="FRE"><s0>Unilatéral</s0>
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</fC03>
<fC03 i1="08" i2="X" l="ENG"><s0>Unilateral</s0>
<s5>23</s5>
</fC03>
<fC03 i1="08" i2="X" l="SPA"><s0>Unilateral</s0>
<s5>23</s5>
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<fC03 i1="09" i2="X" l="FRE"><s0>Efficacité traitement</s0>
<s5>24</s5>
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<fC03 i1="09" i2="X" l="ENG"><s0>Treatment efficiency</s0>
<s5>24</s5>
</fC03>
<fC03 i1="09" i2="X" l="SPA"><s0>Eficacia tratamiento</s0>
<s5>24</s5>
</fC03>
<fC07 i1="01" i2="X" l="FRE"><s0>Système nerveux pathologie</s0>
<s5>37</s5>
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<fC07 i1="01" i2="X" l="ENG"><s0>Nervous system diseases</s0>
<s5>37</s5>
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<s5>37</s5>
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<fC07 i1="02" i2="X" l="FRE"><s0>Système nerveux central pathologie</s0>
<s5>38</s5>
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<fC07 i1="02" i2="X" l="ENG"><s0>Central nervous system disease</s0>
<s5>38</s5>
</fC07>
<fC07 i1="02" i2="X" l="SPA"><s0>Sistema nervosio central patología</s0>
<s5>38</s5>
</fC07>
<fC07 i1="03" i2="X" l="FRE"><s0>Encéphale pathologie</s0>
<s5>39</s5>
</fC07>
<fC07 i1="03" i2="X" l="ENG"><s0>Cerebral disorder</s0>
<s5>39</s5>
</fC07>
<fC07 i1="03" i2="X" l="SPA"><s0>Encéfalo patología</s0>
<s5>39</s5>
</fC07>
<fC07 i1="04" i2="X" l="FRE"><s0>Extrapyramidal syndrome</s0>
<s5>40</s5>
</fC07>
<fC07 i1="04" i2="X" l="ENG"><s0>Extrapyramidal syndrome</s0>
<s5>40</s5>
</fC07>
<fC07 i1="04" i2="X" l="SPA"><s0>Extrapiramidal síndrome</s0>
<s5>40</s5>
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<fC07 i1="05" i2="X" l="FRE"><s0>Maladie dégénérative</s0>
<s5>41</s5>
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<fC07 i1="05" i2="X" l="ENG"><s0>Degenerative disease</s0>
<s5>41</s5>
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<fC07 i1="05" i2="X" l="SPA"><s0>Enfermedad degenerativa</s0>
<s5>41</s5>
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<fC07 i1="06" i2="X" l="FRE"><s0>Chirurgie</s0>
<s5>45</s5>
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<fC07 i1="06" i2="X" l="ENG"><s0>Surgery</s0>
<s5>45</s5>
</fC07>
<fC07 i1="06" i2="X" l="SPA"><s0>Cirugía</s0>
<s5>45</s5>
</fC07>
<fN21><s1>290</s1>
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</pA>
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	La maladie de Parkinson au Canada (serveur d'exploration)
	Attention, ce site est en cours de développement ! Attention, site généré par des moyens informatiques à partir de corpus bruts. Les informations ne sont donc pas validées.

La maladie de Parkinson au Canada (serveur d'exploration)

Long term outcome of unilateral pallidotomy : Follow up of 15 patients for 3 years

Long term outcome of unilateral pallidotomy : Follow up of 15 patients for 3 years

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