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Xenotransplantation of microencapsulated bovine chromaffin cells into hemiparkinsonian monkeys

Identifieur interne : 000048 ( PascalFrancis/Curation ); précédent : 000047; suivant : 000049

Xenotransplantation of microencapsulated bovine chromaffin cells into hemiparkinsonian monkeys

Auteurs : Y. L. Xue [République populaire de Chine] ; Z. F. Wang [République populaire de Chine] ; D. G. Zhong [République populaire de Chine] ; X. Cui [République populaire de Chine] ; X. J. Li [République populaire de Chine] ; X. J. Ma [République populaire de Chine] ; L. N. Wang [République populaire de Chine] ; K. Zhu [République populaire de Chine] ; A. M. Sun [Canada]

Source :

RBID : Pascal:00-0415725

Descripteurs français

English descriptors

Abstract

This study examines the effects of xenografts of microencapsulated bovine chromaffin cells (BCCs) on the rotational behavior of hemiparkinsonian monkey recipients. In addition, it determines the content of monoamine neurotransmitters and their major metabolites in the neostriatum in hemiparkinsonian monkeys. The hemiparkinsonian model in monkeys was induced by a unilateral intracarotid injection of methyl-phenyl-tetrahydropyridine (MPTP). Unencapsulated BCCs, BCCs microencapsulated in alginate-polylysine-alginate (ALA) membranes as well as empty microencapsules were grafted into the neostriatum of the hemiparkinsonian monkeys. Following the transplantation the hemiparkinsonian symptoms subsided and the number of rotations induced by apomorphine decreased for up to nine months in the group of recipients grafted with microencapsulated BCCs, while only a temporary improvement (one month) was detected in the recipients of the unencapsulated BCCs. No change was observed in the recipients of empty microencapsules. Dopamine and its metabolites were found considerably depleted in the MPTP-lesioned side versus the unlesioned side of the neostriatum in the hemiparkinsonian monkeys(P<0.05).
pA  
A01 01  1    @0 1073-1199
A02 01      @0 ABSBE4
A03   1    @0 Artif. cells blood substit. immobil. biotechnol.
A05       @2 28
A06       @2 4
A08 01  1  ENG  @1 Xenotransplantation of microencapsulated bovine chromaffin cells into hemiparkinsonian monkeys
A11 01  1    @1 XUE (Y. L.)
A11 02  1    @1 WANG (Z. F.)
A11 03  1    @1 ZHONG (D. G.)
A11 04  1    @1 CUI (X.)
A11 05  1    @1 LI (X. J.)
A11 06  1    @1 MA (X. J.)
A11 07  1    @1 WANG (L. N.)
A11 08  1    @1 ZHU (K.)
A11 09  1    @1 SUN (A. M.)
A14 01      @1 Institute of Basic Medical Sciences, PLA General Hospital @2 Beijing 100853 @3 CHN @Z 1 aut. @Z 2 aut. @Z 3 aut. @Z 4 aut. @Z 5 aut.
A14 02      @1 Dalian Institute of Chemistry and Physics, The Chinese Academy of Sciences @2 Dalian 116033 @3 CHN @Z 6 aut.
A14 03      @1 Institute of Neurological Diseases, PLA General Hospital @2 Beijing 100853 @3 CHN @Z 7 aut. @Z 8 aut.
A14 04      @1 Department of Physiology, Faculty of Medicine, University of Toronto, 1 King's College Circle @2 Toronto, Ontario, M5S 2A8 @3 CAN @Z 9 aut.
A20       @1 337-345
A21       @1 2000
A23 01      @0 ENG
A43 01      @1 INIST @2 16706 @5 354000090149040050
A44       @0 0000 @1 © 2000 INIST-CNRS. All rights reserved.
A45       @0 9 ref.
A47 01  1    @0 00-0415725
A60       @1 P
A61       @0 A
A64 01  1    @0 Artificial cells, blood substitutes, and immobilization biotechnology
A66 01      @0 USA
C01 01    ENG  @0 This study examines the effects of xenografts of microencapsulated bovine chromaffin cells (BCCs) on the rotational behavior of hemiparkinsonian monkey recipients. In addition, it determines the content of monoamine neurotransmitters and their major metabolites in the neostriatum in hemiparkinsonian monkeys. The hemiparkinsonian model in monkeys was induced by a unilateral intracarotid injection of methyl-phenyl-tetrahydropyridine (MPTP). Unencapsulated BCCs, BCCs microencapsulated in alginate-polylysine-alginate (ALA) membranes as well as empty microencapsules were grafted into the neostriatum of the hemiparkinsonian monkeys. Following the transplantation the hemiparkinsonian symptoms subsided and the number of rotations induced by apomorphine decreased for up to nine months in the group of recipients grafted with microencapsulated BCCs, while only a temporary improvement (one month) was detected in the recipients of the unencapsulated BCCs. No change was observed in the recipients of empty microencapsules. Dopamine and its metabolites were found considerably depleted in the MPTP-lesioned side versus the unlesioned side of the neostriatum in the hemiparkinsonian monkeys(P<0.05).
C02 01  X    @0 002B25J01
C03 01  X  FRE  @0 Parkinson maladie @5 01
C03 01  X  ENG  @0 Parkinson disease @5 01
C03 01  X  SPA  @0 Parkinson enfermedad @5 01
C03 02  X  FRE  @0 Traitement @5 02
C03 02  X  ENG  @0 Treatment @5 02
C03 02  X  SPA  @0 Tratamiento @5 02
C03 03  X  FRE  @0 Implant @5 03
C03 03  X  ENG  @0 Implant @5 03
C03 03  X  SPA  @0 Implante @5 03
C03 04  X  FRE  @0 Microcapsule @5 04
C03 04  X  ENG  @0 Microcapsule @5 04
C03 04  X  SPA  @0 Microcápsula @5 04
C03 05  X  FRE  @0 Cellule chromaffine @5 05
C03 05  X  ENG  @0 Chromaffin cell @5 05
C03 05  X  SPA  @0 Célula cromafín @5 05
C03 06  X  FRE  @0 Encéphale @5 06
C03 06  X  ENG  @0 Brain (vertebrata) @5 06
C03 06  X  SPA  @0 Encéfalo @5 06
C03 07  X  FRE  @0 Hétérogreffe @5 07
C03 07  X  ENG  @0 Heterograft @5 07
C03 07  X  SPA  @0 Heteroinjerto @5 07
C03 08  X  FRE  @0 Corps strié @5 08
C03 08  X  ENG  @0 Corpus striatum @5 08
C03 08  X  SPA  @0 Cuerpo estriado @5 08
C03 09  X  FRE  @0 Origine animale @5 09
C03 09  X  ENG  @0 Animal origin @5 09
C03 09  X  SPA  @0 Origen animal @5 09
C03 10  X  FRE  @0 Bovin @5 10
C03 10  X  ENG  @0 Bovine @5 10
C03 10  X  SPA  @0 Bovino @5 10
C03 11  X  FRE  @0 Microdialyse @5 11
C03 11  X  ENG  @0 Microdialysis @5 11
C03 11  X  SPA  @0 Microdiálisis @5 11
C03 12  X  FRE  @0 Chromatographie HPLC @5 12
C03 12  X  ENG  @0 HPLC chromatography @5 12
C03 12  X  SPA  @0 Cromatografía HPLC @5 12
C03 13  X  FRE  @0 Etude expérimentale @5 17
C03 13  X  ENG  @0 Experimental study @5 17
C03 13  X  SPA  @0 Estudio experimental @5 17
C03 14  X  FRE  @0 Animal @5 18
C03 14  X  ENG  @0 Animal @5 18
C03 14  X  SPA  @0 Animal @5 18
C03 15  X  FRE  @0 Singe @5 19
C03 15  X  ENG  @0 Monkey @5 19
C03 15  X  SPA  @0 Mono @5 19
C03 16  X  FRE  @0 Néostriatum @4 INC @5 86
C03 17  X  FRE  @0 Thérapie cellulaire @4 CD @5 97
C03 17  X  ENG  @0 Cell therapy @4 CD @5 97
C07 01  X  FRE  @0 Artiodactyla @2 NS
C07 01  X  ENG  @0 Artiodactyla @2 NS
C07 01  X  SPA  @0 Artiodactyla @2 NS
C07 02  X  FRE  @0 Ungulata @2 NS
C07 02  X  ENG  @0 Ungulata @2 NS
C07 02  X  SPA  @0 Ungulata @2 NS
C07 03  X  FRE  @0 Mammalia @2 NS
C07 03  X  ENG  @0 Mammalia @2 NS
C07 03  X  SPA  @0 Mammalia @2 NS
C07 04  X  FRE  @0 Vertebrata @2 NS
C07 04  X  ENG  @0 Vertebrata @2 NS
C07 04  X  SPA  @0 Vertebrata @2 NS
C07 05  X  FRE  @0 Primates @2 NS
C07 05  X  ENG  @0 Primates @2 NS
C07 05  X  SPA  @0 Primates @2 NS
C07 06  X  FRE  @0 Système nerveux pathologie @5 37
C07 06  X  ENG  @0 Nervous system diseases @5 37
C07 06  X  SPA  @0 Sistema nervioso patología @5 37
C07 07  X  FRE  @0 Système nerveux central pathologie @5 38
C07 07  X  ENG  @0 Central nervous system disease @5 38
C07 07  X  SPA  @0 Sistema nervosio central patología @5 38
C07 08  X  FRE  @0 Encéphale pathologie @5 39
C07 08  X  ENG  @0 Cerebral disorder @5 39
C07 08  X  SPA  @0 Encéfalo patología @5 39
C07 09  X  FRE  @0 Extrapyramidal syndrome @5 40
C07 09  X  ENG  @0 Extrapyramidal syndrome @5 40
C07 09  X  SPA  @0 Extrapiramidal síndrome @5 40
C07 10  X  FRE  @0 Maladie dégénérative @5 41
C07 10  X  ENG  @0 Degenerative disease @5 41
C07 10  X  SPA  @0 Enfermedad degenerativa @5 41
C07 11  X  FRE  @0 Greffe @5 53
C07 11  X  ENG  @0 Graft @5 53
C07 11  X  SPA  @0 Injerto @5 53
N21       @1 276

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Pascal:00-0415725

Le document en format XML

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<term>Chromaffin cell</term>
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<term>Traitement</term>
<term>Implant</term>
<term>Microcapsule</term>
<term>Cellule chromaffine</term>
<term>Encéphale</term>
<term>Hétérogreffe</term>
<term>Corps strié</term>
<term>Origine animale</term>
<term>Bovin</term>
<term>Microdialyse</term>
<term>Chromatographie HPLC</term>
<term>Etude expérimentale</term>
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</textClass>
</profileDesc>
</teiHeader>
<front>
<div type="abstract" xml:lang="en">This study examines the effects of xenografts of microencapsulated bovine chromaffin cells (BCCs) on the rotational behavior of hemiparkinsonian monkey recipients. In addition, it determines the content of monoamine neurotransmitters and their major metabolites in the neostriatum in hemiparkinsonian monkeys. The hemiparkinsonian model in monkeys was induced by a unilateral intracarotid injection of methyl-phenyl-tetrahydropyridine (MPTP). Unencapsulated BCCs, BCCs microencapsulated in alginate-polylysine-alginate (ALA) membranes as well as empty microencapsules were grafted into the neostriatum of the hemiparkinsonian monkeys. Following the transplantation the hemiparkinsonian symptoms subsided and the number of rotations induced by apomorphine decreased for up to nine months in the group of recipients grafted with microencapsulated BCCs, while only a temporary improvement (one month) was detected in the recipients of the unencapsulated BCCs. No change was observed in the recipients of empty microencapsules. Dopamine and its metabolites were found considerably depleted in the MPTP-lesioned side versus the unlesioned side of the neostriatum in the hemiparkinsonian monkeys(P<0.05).</div>
</front>
</TEI>
<inist>
<standard h6="B">
<pA>
<fA01 i1="01" i2="1">
<s0>1073-1199</s0>
</fA01>
<fA02 i1="01">
<s0>ABSBE4</s0>
</fA02>
<fA03 i2="1">
<s0>Artif. cells blood substit. immobil. biotechnol.</s0>
</fA03>
<fA05>
<s2>28</s2>
</fA05>
<fA06>
<s2>4</s2>
</fA06>
<fA08 i1="01" i2="1" l="ENG">
<s1>Xenotransplantation of microencapsulated bovine chromaffin cells into hemiparkinsonian monkeys</s1>
</fA08>
<fA11 i1="01" i2="1">
<s1>XUE (Y. L.)</s1>
</fA11>
<fA11 i1="02" i2="1">
<s1>WANG (Z. F.)</s1>
</fA11>
<fA11 i1="03" i2="1">
<s1>ZHONG (D. G.)</s1>
</fA11>
<fA11 i1="04" i2="1">
<s1>CUI (X.)</s1>
</fA11>
<fA11 i1="05" i2="1">
<s1>LI (X. J.)</s1>
</fA11>
<fA11 i1="06" i2="1">
<s1>MA (X. J.)</s1>
</fA11>
<fA11 i1="07" i2="1">
<s1>WANG (L. N.)</s1>
</fA11>
<fA11 i1="08" i2="1">
<s1>ZHU (K.)</s1>
</fA11>
<fA11 i1="09" i2="1">
<s1>SUN (A. M.)</s1>
</fA11>
<fA14 i1="01">
<s1>Institute of Basic Medical Sciences, PLA General Hospital</s1>
<s2>Beijing 100853</s2>
<s3>CHN</s3>
<sZ>1 aut.</sZ>
<sZ>2 aut.</sZ>
<sZ>3 aut.</sZ>
<sZ>4 aut.</sZ>
<sZ>5 aut.</sZ>
</fA14>
<fA14 i1="02">
<s1>Dalian Institute of Chemistry and Physics, The Chinese Academy of Sciences</s1>
<s2>Dalian 116033</s2>
<s3>CHN</s3>
<sZ>6 aut.</sZ>
</fA14>
<fA14 i1="03">
<s1>Institute of Neurological Diseases, PLA General Hospital</s1>
<s2>Beijing 100853</s2>
<s3>CHN</s3>
<sZ>7 aut.</sZ>
<sZ>8 aut.</sZ>
</fA14>
<fA14 i1="04">
<s1>Department of Physiology, Faculty of Medicine, University of Toronto, 1 King's College Circle</s1>
<s2>Toronto, Ontario, M5S 2A8</s2>
<s3>CAN</s3>
<sZ>9 aut.</sZ>
</fA14>
<fA20>
<s1>337-345</s1>
</fA20>
<fA21>
<s1>2000</s1>
</fA21>
<fA23 i1="01">
<s0>ENG</s0>
</fA23>
<fA43 i1="01">
<s1>INIST</s1>
<s2>16706</s2>
<s5>354000090149040050</s5>
</fA43>
<fA44>
<s0>0000</s0>
<s1>© 2000 INIST-CNRS. All rights reserved.</s1>
</fA44>
<fA45>
<s0>9 ref.</s0>
</fA45>
<fA47 i1="01" i2="1">
<s0>00-0415725</s0>
</fA47>
<fA60>
<s1>P</s1>
</fA60>
<fA61>
<s0>A</s0>
</fA61>
<fA64 i1="01" i2="1">
<s0>Artificial cells, blood substitutes, and immobilization biotechnology</s0>
</fA64>
<fA66 i1="01">
<s0>USA</s0>
</fA66>
<fC01 i1="01" l="ENG">
<s0>This study examines the effects of xenografts of microencapsulated bovine chromaffin cells (BCCs) on the rotational behavior of hemiparkinsonian monkey recipients. In addition, it determines the content of monoamine neurotransmitters and their major metabolites in the neostriatum in hemiparkinsonian monkeys. The hemiparkinsonian model in monkeys was induced by a unilateral intracarotid injection of methyl-phenyl-tetrahydropyridine (MPTP). Unencapsulated BCCs, BCCs microencapsulated in alginate-polylysine-alginate (ALA) membranes as well as empty microencapsules were grafted into the neostriatum of the hemiparkinsonian monkeys. Following the transplantation the hemiparkinsonian symptoms subsided and the number of rotations induced by apomorphine decreased for up to nine months in the group of recipients grafted with microencapsulated BCCs, while only a temporary improvement (one month) was detected in the recipients of the unencapsulated BCCs. No change was observed in the recipients of empty microencapsules. Dopamine and its metabolites were found considerably depleted in the MPTP-lesioned side versus the unlesioned side of the neostriatum in the hemiparkinsonian monkeys(P<0.05).</s0>
</fC01>
<fC02 i1="01" i2="X">
<s0>002B25J01</s0>
</fC02>
<fC03 i1="01" i2="X" l="FRE">
<s0>Parkinson maladie</s0>
<s5>01</s5>
</fC03>
<fC03 i1="01" i2="X" l="ENG">
<s0>Parkinson disease</s0>
<s5>01</s5>
</fC03>
<fC03 i1="01" i2="X" l="SPA">
<s0>Parkinson enfermedad</s0>
<s5>01</s5>
</fC03>
<fC03 i1="02" i2="X" l="FRE">
<s0>Traitement</s0>
<s5>02</s5>
</fC03>
<fC03 i1="02" i2="X" l="ENG">
<s0>Treatment</s0>
<s5>02</s5>
</fC03>
<fC03 i1="02" i2="X" l="SPA">
<s0>Tratamiento</s0>
<s5>02</s5>
</fC03>
<fC03 i1="03" i2="X" l="FRE">
<s0>Implant</s0>
<s5>03</s5>
</fC03>
<fC03 i1="03" i2="X" l="ENG">
<s0>Implant</s0>
<s5>03</s5>
</fC03>
<fC03 i1="03" i2="X" l="SPA">
<s0>Implante</s0>
<s5>03</s5>
</fC03>
<fC03 i1="04" i2="X" l="FRE">
<s0>Microcapsule</s0>
<s5>04</s5>
</fC03>
<fC03 i1="04" i2="X" l="ENG">
<s0>Microcapsule</s0>
<s5>04</s5>
</fC03>
<fC03 i1="04" i2="X" l="SPA">
<s0>Microcápsula</s0>
<s5>04</s5>
</fC03>
<fC03 i1="05" i2="X" l="FRE">
<s0>Cellule chromaffine</s0>
<s5>05</s5>
</fC03>
<fC03 i1="05" i2="X" l="ENG">
<s0>Chromaffin cell</s0>
<s5>05</s5>
</fC03>
<fC03 i1="05" i2="X" l="SPA">
<s0>Célula cromafín</s0>
<s5>05</s5>
</fC03>
<fC03 i1="06" i2="X" l="FRE">
<s0>Encéphale</s0>
<s5>06</s5>
</fC03>
<fC03 i1="06" i2="X" l="ENG">
<s0>Brain (vertebrata)</s0>
<s5>06</s5>
</fC03>
<fC03 i1="06" i2="X" l="SPA">
<s0>Encéfalo</s0>
<s5>06</s5>
</fC03>
<fC03 i1="07" i2="X" l="FRE">
<s0>Hétérogreffe</s0>
<s5>07</s5>
</fC03>
<fC03 i1="07" i2="X" l="ENG">
<s0>Heterograft</s0>
<s5>07</s5>
</fC03>
<fC03 i1="07" i2="X" l="SPA">
<s0>Heteroinjerto</s0>
<s5>07</s5>
</fC03>
<fC03 i1="08" i2="X" l="FRE">
<s0>Corps strié</s0>
<s5>08</s5>
</fC03>
<fC03 i1="08" i2="X" l="ENG">
<s0>Corpus striatum</s0>
<s5>08</s5>
</fC03>
<fC03 i1="08" i2="X" l="SPA">
<s0>Cuerpo estriado</s0>
<s5>08</s5>
</fC03>
<fC03 i1="09" i2="X" l="FRE">
<s0>Origine animale</s0>
<s5>09</s5>
</fC03>
<fC03 i1="09" i2="X" l="ENG">
<s0>Animal origin</s0>
<s5>09</s5>
</fC03>
<fC03 i1="09" i2="X" l="SPA">
<s0>Origen animal</s0>
<s5>09</s5>
</fC03>
<fC03 i1="10" i2="X" l="FRE">
<s0>Bovin</s0>
<s5>10</s5>
</fC03>
<fC03 i1="10" i2="X" l="ENG">
<s0>Bovine</s0>
<s5>10</s5>
</fC03>
<fC03 i1="10" i2="X" l="SPA">
<s0>Bovino</s0>
<s5>10</s5>
</fC03>
<fC03 i1="11" i2="X" l="FRE">
<s0>Microdialyse</s0>
<s5>11</s5>
</fC03>
<fC03 i1="11" i2="X" l="ENG">
<s0>Microdialysis</s0>
<s5>11</s5>
</fC03>
<fC03 i1="11" i2="X" l="SPA">
<s0>Microdiálisis</s0>
<s5>11</s5>
</fC03>
<fC03 i1="12" i2="X" l="FRE">
<s0>Chromatographie HPLC</s0>
<s5>12</s5>
</fC03>
<fC03 i1="12" i2="X" l="ENG">
<s0>HPLC chromatography</s0>
<s5>12</s5>
</fC03>
<fC03 i1="12" i2="X" l="SPA">
<s0>Cromatografía HPLC</s0>
<s5>12</s5>
</fC03>
<fC03 i1="13" i2="X" l="FRE">
<s0>Etude expérimentale</s0>
<s5>17</s5>
</fC03>
<fC03 i1="13" i2="X" l="ENG">
<s0>Experimental study</s0>
<s5>17</s5>
</fC03>
<fC03 i1="13" i2="X" l="SPA">
<s0>Estudio experimental</s0>
<s5>17</s5>
</fC03>
<fC03 i1="14" i2="X" l="FRE">
<s0>Animal</s0>
<s5>18</s5>
</fC03>
<fC03 i1="14" i2="X" l="ENG">
<s0>Animal</s0>
<s5>18</s5>
</fC03>
<fC03 i1="14" i2="X" l="SPA">
<s0>Animal</s0>
<s5>18</s5>
</fC03>
<fC03 i1="15" i2="X" l="FRE">
<s0>Singe</s0>
<s5>19</s5>
</fC03>
<fC03 i1="15" i2="X" l="ENG">
<s0>Monkey</s0>
<s5>19</s5>
</fC03>
<fC03 i1="15" i2="X" l="SPA">
<s0>Mono</s0>
<s5>19</s5>
</fC03>
<fC03 i1="16" i2="X" l="FRE">
<s0>Néostriatum</s0>
<s4>INC</s4>
<s5>86</s5>
</fC03>
<fC03 i1="17" i2="X" l="FRE">
<s0>Thérapie cellulaire</s0>
<s4>CD</s4>
<s5>97</s5>
</fC03>
<fC03 i1="17" i2="X" l="ENG">
<s0>Cell therapy</s0>
<s4>CD</s4>
<s5>97</s5>
</fC03>
<fC07 i1="01" i2="X" l="FRE">
<s0>Artiodactyla</s0>
<s2>NS</s2>
</fC07>
<fC07 i1="01" i2="X" l="ENG">
<s0>Artiodactyla</s0>
<s2>NS</s2>
</fC07>
<fC07 i1="01" i2="X" l="SPA">
<s0>Artiodactyla</s0>
<s2>NS</s2>
</fC07>
<fC07 i1="02" i2="X" l="FRE">
<s0>Ungulata</s0>
<s2>NS</s2>
</fC07>
<fC07 i1="02" i2="X" l="ENG">
<s0>Ungulata</s0>
<s2>NS</s2>
</fC07>
<fC07 i1="02" i2="X" l="SPA">
<s0>Ungulata</s0>
<s2>NS</s2>
</fC07>
<fC07 i1="03" i2="X" l="FRE">
<s0>Mammalia</s0>
<s2>NS</s2>
</fC07>
<fC07 i1="03" i2="X" l="ENG">
<s0>Mammalia</s0>
<s2>NS</s2>
</fC07>
<fC07 i1="03" i2="X" l="SPA">
<s0>Mammalia</s0>
<s2>NS</s2>
</fC07>
<fC07 i1="04" i2="X" l="FRE">
<s0>Vertebrata</s0>
<s2>NS</s2>
</fC07>
<fC07 i1="04" i2="X" l="ENG">
<s0>Vertebrata</s0>
<s2>NS</s2>
</fC07>
<fC07 i1="04" i2="X" l="SPA">
<s0>Vertebrata</s0>
<s2>NS</s2>
</fC07>
<fC07 i1="05" i2="X" l="FRE">
<s0>Primates</s0>
<s2>NS</s2>
</fC07>
<fC07 i1="05" i2="X" l="ENG">
<s0>Primates</s0>
<s2>NS</s2>
</fC07>
<fC07 i1="05" i2="X" l="SPA">
<s0>Primates</s0>
<s2>NS</s2>
</fC07>
<fC07 i1="06" i2="X" l="FRE">
<s0>Système nerveux pathologie</s0>
<s5>37</s5>
</fC07>
<fC07 i1="06" i2="X" l="ENG">
<s0>Nervous system diseases</s0>
<s5>37</s5>
</fC07>
<fC07 i1="06" i2="X" l="SPA">
<s0>Sistema nervioso patología</s0>
<s5>37</s5>
</fC07>
<fC07 i1="07" i2="X" l="FRE">
<s0>Système nerveux central pathologie</s0>
<s5>38</s5>
</fC07>
<fC07 i1="07" i2="X" l="ENG">
<s0>Central nervous system disease</s0>
<s5>38</s5>
</fC07>
<fC07 i1="07" i2="X" l="SPA">
<s0>Sistema nervosio central patología</s0>
<s5>38</s5>
</fC07>
<fC07 i1="08" i2="X" l="FRE">
<s0>Encéphale pathologie</s0>
<s5>39</s5>
</fC07>
<fC07 i1="08" i2="X" l="ENG">
<s0>Cerebral disorder</s0>
<s5>39</s5>
</fC07>
<fC07 i1="08" i2="X" l="SPA">
<s0>Encéfalo patología</s0>
<s5>39</s5>
</fC07>
<fC07 i1="09" i2="X" l="FRE">
<s0>Extrapyramidal syndrome</s0>
<s5>40</s5>
</fC07>
<fC07 i1="09" i2="X" l="ENG">
<s0>Extrapyramidal syndrome</s0>
<s5>40</s5>
</fC07>
<fC07 i1="09" i2="X" l="SPA">
<s0>Extrapiramidal síndrome</s0>
<s5>40</s5>
</fC07>
<fC07 i1="10" i2="X" l="FRE">
<s0>Maladie dégénérative</s0>
<s5>41</s5>
</fC07>
<fC07 i1="10" i2="X" l="ENG">
<s0>Degenerative disease</s0>
<s5>41</s5>
</fC07>
<fC07 i1="10" i2="X" l="SPA">
<s0>Enfermedad degenerativa</s0>
<s5>41</s5>
</fC07>
<fC07 i1="11" i2="X" l="FRE">
<s0>Greffe</s0>
<s5>53</s5>
</fC07>
<fC07 i1="11" i2="X" l="ENG">
<s0>Graft</s0>
<s5>53</s5>
</fC07>
<fC07 i1="11" i2="X" l="SPA">
<s0>Injerto</s0>
<s5>53</s5>
</fC07>
<fN21>
<s1>276</s1>
</fN21>
</pA>
</standard>
</inist>
</record>

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