ParkinsonCanadaV1, PascalFrancis, Corpus, bibRecord, 000D00

Sex differences in catalepsy : evidence for hormone-dependent postural mechanisms in haloperidol-treated rats

Identifieur interne : 000D00 ( PascalFrancis/Corpus ); précédent : 000C99; suivant : 000D01

Sex differences in catalepsy : evidence for hormone-dependent postural mechanisms in haloperidol-treated rats

Auteurs : E. F. Field ; I. Q. Whishaw ; S. M. Pellis

Source :

Behavioural brain research [ 0166-4328 ] ; 2000.

RBID : Pascal:00-0266275

Descripteurs français

Pascal (Inist)
- Catalepsie, Modèle animal, Parkinson maladie, Récepteur dopaminergique, Antagoniste, Hormone stéroïde sexuelle, Castration, Ovariectomie, Animal, Rat, Sexe, Posture.

English descriptors

KwdEn :
- Animal, Animal model, Antagonist, Castration, Catalepsy, Dopamine receptor, Ovariectomy, Parkinson disease, Posture, Rat, Sex, Sex steroid hormone.

Abstract

Catalepsy, a symptom of Parkinson's disease and related disorders can be produced in rats and other laboratory animals by the blockade of nigrostriatal dopamine using dopaminergic antagonists such as haloperidol. When haloperidol-induced cataleptic rats are placed facing downward on an inclined plane, they will brace against the resulting downward force by pushing backwards, and if they lose postural stability, or their position on the inclined plane, they will jump forward. Females, however, jump from the inclined plane at a significantly lower angle than do males. Frame-by-frame analysis of the jumping sequences revealed that females and males use a different combination of postural adjustments to maintain their position on the inclined plane prior to jumping. Furthermore, gonadal hormone manipulations at birth and in adulthood reveal that these sex differences in postural adjustments are dependent on the organizational effects of gonadal hormones in the perinatal period. These results provide evidence for sex differences in postural support mechanisms and suggest that the sex of subjects, or their hormonal state, must be considered when studying the behavioral aspects of neurological disorders such as Parkinson's disease which include a postural component.

Notice en format standard (ISO 2709)

Pour connaître la documentation sur le format Inist Standard.

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A02	`01`			`@0 BBREDI`
A03		`1`		`@0 Behav. brain res.`
A05				`@2 109`
A06				`@2 2`
A08	`01`	`1`	`ENG`	`@1 Sex differences in catalepsy : evidence for hormone-dependent postural mechanisms in haloperidol-treated rats`
A11	`01`	`1`		`@1 FIELD (E. F.)`
A11	`02`	`1`		`@1 WHISHAW (I. Q.)`
A11	`03`	`1`		`@1 PELLIS (S. M.)`
A14	`01`			`@1 Department of Psychology and Neuroscience, University of Lethbridge @2 Lethbridge, Alta, T1K 3M4 @3 CAN @Z 1 aut. @Z 2 aut. @Z 3 aut.`
A20				`@1 207-212`
A21				`@1 2000`
A23	`01`			`@0 ENG`
A43	`01`			`@1 INIST @2 18271 @5 354000087104780060`
A44				`@0 0000 @1 © 2000 INIST-CNRS. All rights reserved.`
A45				`@0 36 ref.`
A47	`01`	`1`		`@0 00-0266275`
A60				`@1 P`
A61				`@0 A`
A64	`01`	`1`		`@0 Behavioural brain research`
A66	`01`			`@0 IRL`
C01	`01`		`ENG`	@0 Catalepsy, a symptom of Parkinson's disease and related disorders can be produced in rats and other laboratory animals by the blockade of nigrostriatal dopamine using dopaminergic antagonists such as haloperidol. When haloperidol-induced cataleptic rats are placed facing downward on an inclined plane, they will brace against the resulting downward force by pushing backwards, and if they lose postural stability, or their position on the inclined plane, they will jump forward. Females, however, jump from the inclined plane at a significantly lower angle than do males. Frame-by-frame analysis of the jumping sequences revealed that females and males use a different combination of postural adjustments to maintain their position on the inclined plane prior to jumping. Furthermore, gonadal hormone manipulations at birth and in adulthood reveal that these sex differences in postural adjustments are dependent on the organizational effects of gonadal hormones in the perinatal period. These results provide evidence for sex differences in postural support mechanisms and suggest that the sex of subjects, or their hormonal state, must be considered when studying the behavioral aspects of neurological disorders such as Parkinson's disease which include a postural component.
C02	`01`	`X`		`@0 002A26C03`
C03	`01`	`X`	`FRE`	`@0 Catalepsie @5 01`
C03	`01`	`X`	`ENG`	`@0 Catalepsy @5 01`
C03	`01`	`X`	`SPA`	`@0 Catalepsia @5 01`
C03	`02`	`X`	`FRE`	`@0 Modèle animal @5 02`
C03	`02`	`X`	`ENG`	`@0 Animal model @5 02`
C03	`02`	`X`	`SPA`	`@0 Modelo animal @5 02`
C03	`03`	`X`	`FRE`	`@0 Parkinson maladie @5 03`
C03	`03`	`X`	`ENG`	`@0 Parkinson disease @5 03`
C03	`03`	`X`	`SPA`	`@0 Parkinson enfermedad @5 03`
C03	`04`	`X`	`FRE`	`@0 Récepteur dopaminergique @5 04`
C03	`04`	`X`	`ENG`	`@0 Dopamine receptor @5 04`
C03	`04`	`X`	`SPA`	`@0 Receptor dopaminérgico @5 04`
C03	`05`	`X`	`FRE`	`@0 Antagoniste @5 05`
C03	`05`	`X`	`ENG`	`@0 Antagonist @5 05`
C03	`05`	`X`	`SPA`	`@0 Antagonista @5 05`
C03	`06`	`X`	`FRE`	`@0 Hormone stéroïde sexuelle @5 06`
C03	`06`	`X`	`ENG`	`@0 Sex steroid hormone @5 06`
C03	`06`	`X`	`SPA`	`@0 Hormona esteroide sexual @5 06`
C03	`07`	`X`	`FRE`	`@0 Castration @5 07`
C03	`07`	`X`	`ENG`	`@0 Castration @5 07`
C03	`07`	`X`	`SPA`	`@0 Castración @5 07`
C03	`08`	`X`	`FRE`	`@0 Ovariectomie @5 08`
C03	`08`	`X`	`ENG`	`@0 Ovariectomy @5 08`
C03	`08`	`X`	`SPA`	`@0 Ovariectomía @5 08`
C03	`09`	`X`	`FRE`	`@0 Animal @5 54`
C03	`09`	`X`	`ENG`	`@0 Animal @5 54`
C03	`09`	`X`	`SPA`	`@0 Animal @5 54`
C03	`10`	`X`	`FRE`	`@0 Rat @5 55`
C03	`10`	`X`	`ENG`	`@0 Rat @5 55`
C03	`10`	`X`	`SPA`	`@0 Rata @5 55`
C03	`11`	`X`	`FRE`	`@0 Sexe @5 57`
C03	`11`	`X`	`ENG`	`@0 Sex @5 57`
C03	`11`	`X`	`SPA`	`@0 Sexo @5 57`
C03	`12`	`X`	`FRE`	`@0 Posture @5 60`
C03	`12`	`X`	`ENG`	`@0 Posture @5 60`
C03	`12`	`X`	`SPA`	`@0 Postura @5 60`
C07	`01`	`X`	`FRE`	`@0 Rodentia @2 NS`
C07	`01`	`X`	`ENG`	`@0 Rodentia @2 NS`
C07	`01`	`X`	`SPA`	`@0 Rodentia @2 NS`
C07	`02`	`X`	`FRE`	`@0 Mammalia @2 NS`
C07	`02`	`X`	`ENG`	`@0 Mammalia @2 NS`
C07	`02`	`X`	`SPA`	`@0 Mammalia @2 NS`
C07	`03`	`X`	`FRE`	`@0 Vertebrata @2 NS`
C07	`03`	`X`	`ENG`	`@0 Vertebrata @2 NS`
C07	`03`	`X`	`SPA`	`@0 Vertebrata @2 NS`
N21				`@1 178`

Format Inist (serveur)

NO :	PASCAL 00-0266275 INIST
ET :	Sex differences in catalepsy : evidence for hormone-dependent postural mechanisms in haloperidol-treated rats
AU :	FIELD (E. F.); WHISHAW (I. Q.); PELLIS (S. M.)
AF :	Department of Psychology and Neuroscience, University of Lethbridge/Lethbridge, Alta, T1K 3M4/Canada (1 aut., 2 aut., 3 aut.)
DT :	Publication en série; Niveau analytique
SO :	Behavioural brain research; ISSN 0166-4328; Coden BBREDI; Irlande; Da. 2000; Vol. 109; No. 2; Pp. 207-212; Bibl. 36 ref.
LA :	Anglais
EA :	Catalepsy, a symptom of Parkinson's disease and related disorders can be produced in rats and other laboratory animals by the blockade of nigrostriatal dopamine using dopaminergic antagonists such as haloperidol. When haloperidol-induced cataleptic rats are placed facing downward on an inclined plane, they will brace against the resulting downward force by pushing backwards, and if they lose postural stability, or their position on the inclined plane, they will jump forward. Females, however, jump from the inclined plane at a significantly lower angle than do males. Frame-by-frame analysis of the jumping sequences revealed that females and males use a different combination of postural adjustments to maintain their position on the inclined plane prior to jumping. Furthermore, gonadal hormone manipulations at birth and in adulthood reveal that these sex differences in postural adjustments are dependent on the organizational effects of gonadal hormones in the perinatal period. These results provide evidence for sex differences in postural support mechanisms and suggest that the sex of subjects, or their hormonal state, must be considered when studying the behavioral aspects of neurological disorders such as Parkinson's disease which include a postural component.
CC :	002A26C03
FD :	Catalepsie; Modèle animal; Parkinson maladie; Récepteur dopaminergique; Antagoniste; Hormone stéroïde sexuelle; Castration; Ovariectomie; Animal; Rat; Sexe; Posture
FG :	Rodentia; Mammalia; Vertebrata
ED :	Catalepsy; Animal model; Parkinson disease; Dopamine receptor; Antagonist; Sex steroid hormone; Castration; Ovariectomy; Animal; Rat; Sex; Posture
EG :	Rodentia; Mammalia; Vertebrata
SD :	Catalepsia; Modelo animal; Parkinson enfermedad; Receptor dopaminérgico; Antagonista; Hormona esteroide sexual; Castración; Ovariectomía; Animal; Rata; Sexo; Postura
LO :	INIST-18271.354000087104780060
ID :	00-0266275

Links to Exploration step

Pascal:00-0266275

Le document en format XML

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<front><div type="abstract" xml:lang="en">Catalepsy, a symptom of Parkinson's disease and related disorders can be produced in rats and other laboratory animals by the blockade of nigrostriatal dopamine using dopaminergic antagonists such as haloperidol. When haloperidol-induced cataleptic rats are placed facing downward on an inclined plane, they will brace against the resulting downward force by pushing backwards, and if they lose postural stability, or their position on the inclined plane, they will jump forward. Females, however, jump from the inclined plane at a significantly lower angle than do males. Frame-by-frame analysis of the jumping sequences revealed that females and males use a different combination of postural adjustments to maintain their position on the inclined plane prior to jumping. Furthermore, gonadal hormone manipulations at birth and in adulthood reveal that these sex differences in postural adjustments are dependent on the organizational effects of gonadal hormones in the perinatal period. These results provide evidence for sex differences in postural support mechanisms and suggest that the sex of subjects, or their hormonal state, must be considered when studying the behavioral aspects of neurological disorders such as Parkinson's disease which include a postural component.</div>
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<server><NO>PASCAL 00-0266275 INIST</NO>
<ET>Sex differences in catalepsy : evidence for hormone-dependent postural mechanisms in haloperidol-treated rats</ET>
<AU>FIELD (E. F.); WHISHAW (I. Q.); PELLIS (S. M.)</AU>
<AF>Department of Psychology and Neuroscience, University of Lethbridge/Lethbridge, Alta, T1K 3M4/Canada (1 aut., 2 aut., 3 aut.)</AF>
<DT>Publication en série; Niveau analytique</DT>
<SO>Behavioural brain research; ISSN 0166-4328; Coden BBREDI; Irlande; Da. 2000; Vol. 109; No. 2; Pp. 207-212; Bibl. 36 ref.</SO>
<LA>Anglais</LA>
<EA>Catalepsy, a symptom of Parkinson's disease and related disorders can be produced in rats and other laboratory animals by the blockade of nigrostriatal dopamine using dopaminergic antagonists such as haloperidol. When haloperidol-induced cataleptic rats are placed facing downward on an inclined plane, they will brace against the resulting downward force by pushing backwards, and if they lose postural stability, or their position on the inclined plane, they will jump forward. Females, however, jump from the inclined plane at a significantly lower angle than do males. Frame-by-frame analysis of the jumping sequences revealed that females and males use a different combination of postural adjustments to maintain their position on the inclined plane prior to jumping. Furthermore, gonadal hormone manipulations at birth and in adulthood reveal that these sex differences in postural adjustments are dependent on the organizational effects of gonadal hormones in the perinatal period. These results provide evidence for sex differences in postural support mechanisms and suggest that the sex of subjects, or their hormonal state, must be considered when studying the behavioral aspects of neurological disorders such as Parkinson's disease which include a postural component.</EA>
<CC>002A26C03</CC>
<FD>Catalepsie; Modèle animal; Parkinson maladie; Récepteur dopaminergique; Antagoniste; Hormone stéroïde sexuelle; Castration; Ovariectomie; Animal; Rat; Sexe; Posture</FD>
<FG>Rodentia; Mammalia; Vertebrata</FG>
<ED>Catalepsy; Animal model; Parkinson disease; Dopamine receptor; Antagonist; Sex steroid hormone; Castration; Ovariectomy; Animal; Rat; Sex; Posture</ED>
<EG>Rodentia; Mammalia; Vertebrata</EG>
<SD>Catalepsia; Modelo animal; Parkinson enfermedad; Receptor dopaminérgico; Antagonista; Hormona esteroide sexual; Castración; Ovariectomía; Animal; Rata; Sexo; Postura</SD>
<LO>INIST-18271.354000087104780060</LO>
<ID>00-0266275</ID>
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	La maladie de Parkinson au Canada (serveur d'exploration)
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La maladie de Parkinson au Canada (serveur d'exploration)

Sex differences in catalepsy : evidence for hormone-dependent postural mechanisms in haloperidol-treated rats

Sex differences in catalepsy : evidence for hormone-dependent postural mechanisms in haloperidol-treated rats

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