ParkinsonCanadaV1, PascalFrancis, Corpus, bibRecord, 000C48

eep brain stimulation of the globus pallidus pars interna in advanced Parkinson's disease

Identifieur interne : 000C48 ( PascalFrancis/Corpus ); précédent : 000C47; suivant : 000C49

eep brain stimulation of the globus pallidus pars interna in advanced Parkinson's disease

Auteurs : R. Kumar ; A. E. Lang ; M. C. Rodriguez-Oroz ; A. M. Lozano ; P. Limousin ; P. Pollak ; A. L. Benabid ; J. Guridi ; E. Ramos ; C. Van Der Linden ; A. Vandewalle ; J. Caemaert ; E. Lannoo ; D. Van Den Abbeele ; G. Vingerhoets ; M. Wolters ; J. A. Obeso

Source :

Neurology [ 0028-3878 ] ; 2000.

RBID : Pascal:01-0106279

Descripteurs français

Pascal (Inist)
- Parkinson maladie, Stimulation instrumentale, Encéphale, Pallidum, Traitement, Homme.

English descriptors

KwdEn :
- Brain (vertebrata), Human, Instrumental stimulation, Pallidum, Parkinson disease, Treatment.

Abstract

Article abstract-Pallidotomy is now widely performed for the treatment of advanced Parkinson's disease (PD). Preliminary reports of the effect of globus pallidus pars interna deep brain stimulation (GPi DBS) have also been promising. We have analyzed a cohort of 22 consecutive patients enrolled in a multicenter study. Surgery was bilateral in 17 and unilateral in five patients. At 6-month follow-up, the bilaterally GPi-implanted patients demonstrated a marked improvement when examined after drug withdrawal ("off") and under optimal medication ("on") using the Unified Parkinson's Disease Rating Scale (UPDRS). The benefit induced by the stimulation in the "off" medication condition in the total motor score was 31% and in the activities of daily living (ADL) scores was 39%. During the "on" medication period, the reduction in the total "on" dyskinesias score was 66% and in the ADL score was 32%. A similar pattern of improvement was seen in the group of patients with unilateral GPi stimulation, although a second cohort of 12 patients not included in the multicenter study showed greater improvements in "on" motor functioning. Although the effect of DBS is predominantly reversible, electrode insertion alone resulted in measurable clinical effects in the absence of stimulation. Thus, at 6-month follow-up, the benefit observed without stimulation was up to 44% in the "on" dyskinesias score and 29% in timed tapping scores undertaken in the "off" medication state. Complications among 34 patients from all centers included perioperative infection (n=3), hardware fracture (n=2), and premature battery failure (n=3). These results show a positive antiparkinsonian effect of pallidal DBS. No specific complications were observed with bilateral procedures. s disease.

Notice en format standard (ISO 2709)

Pour connaître la documentation sur le format Inist Standard.

A01	`01`	`1`		`@0 0028-3878`
A02	`01`			`@0 NEURAI`
A03		`1`		`@0 Neurology`
A05				`@2 55`
A06				`@2 12 @3 SUP6`
A08	`01`	`1`	`ENG`	`@1 eep brain stimulation of the globus pallidus pars interna in advanced Parkinson's disease`
A09	`01`	`1`	`ENG`	`@1 Deep Brain Stimulation for Parkinson's Disease and Tremor`
A11	`01`	`1`		`@1 KUMAR (R.)`
A11	`02`	`1`		`@1 LANG (A. E.)`
A11	`03`	`1`		`@1 RODRIGUEZ-OROZ (M. C.)`
A11	`04`	`1`		`@1 LOZANO (A. M.)`
A11	`05`	`1`		`@1 LIMOUSIN (P.)`
A11	`06`	`1`		`@1 POLLAK (P.)`
A11	`07`	`1`		`@1 BENABID (A. L.)`
A11	`08`	`1`		`@1 GURIDI (J.)`
A11	`09`	`1`		`@1 RAMOS (E.)`
A11	`10`	`1`		`@1 VAN DER LINDEN (C.)`
A11	`11`	`1`		`@1 VANDEWALLE (A.)`
A11	`12`	`1`		`@1 CAEMAERT (J.)`
A11	`13`	`1`		`@1 LANNOO (E.)`
A11	`14`	`1`		`@1 VAN DEN ABBEELE (D.)`
A11	`15`	`1`		`@1 VINGERHOETS (G.)`
A11	`16`	`1`		`@1 WOLTERS (M.)`
A11	`17`	`1`		`@1 OBESO (J. A.)`
A12	`01`	`1`		`@1 OBESO (J. A.) @9 ed.`
A12	`02`	`1`		`@1 BENABID (A.) @9 ed.`
A12	`03`	`1`		`@1 KOLLER (W.) @9 ed.`
A14	`01`			`@1 Division of Neurology and Neurosurgery, University of Toronto Medical School Toronto @2 Ontario @3 CAN @Z 1 aut. @Z 2 aut. @Z 4 aut.`
A14	`02`			`@1 Department of Neurology, Neuroscience Center, Clinica Universitaria and Medical School, University Navarra @2 Pamplona @3 ESP @Z 3 aut. @Z 17 aut.`
A14	`03`			`@1 Service of Neurosurgery and Neurology, CHRV @2 Grenoble @3 FRA @Z 5 aut. @Z 6 aut. @Z 7 aut.`
A14	`04`			`@1 Clinica Quiron @2 San Sebastian @3 ESP @Z 8 aut. @Z 9 aut.`
A14	`05`			`@1 Departments of Neurosurgery and Neurology, University Hospital Ghent @2 Ghent @3 BEL @Z 10 aut. @Z 11 aut. @Z 12 aut. @Z 13 aut. @Z 14 aut. @Z 15 aut. @Z 16 aut.`
A15	`01`			`@1 Department of Neurology and Neurosurgery, Neuroscience Program, Clinica Universitaria and Medical School, University of Navarra @2 Pamplona @3 ESP @Z 1 aut.`
A15	`02`			`@1 University of Miami Medical Center, Department of Neurology @2 Miami, Florida @3 USA @Z 3 aut.`
A20				`@2 S34-S39`
A21				`@1 2000`
A23	`01`			`@0 ENG`
A43	`01`			`@1 INIST @2 6345 @5 354000093591920070`
A44				`@0 0000 @1 © 2001 INIST-CNRS. All rights reserved.`
A45				`@0 32 ref.`
A47	`01`	`1`		`@0 01-0106279`
A60				`@1 P @2 C`
A61				`@0 A`
A64	`01`	`1`		`@0 Neurology`
A66	`01`			`@0 USA`
C01	`01`		`ENG`	@0 Article abstract-Pallidotomy is now widely performed for the treatment of advanced Parkinson's disease (PD). Preliminary reports of the effect of globus pallidus pars interna deep brain stimulation (GPi DBS) have also been promising. We have analyzed a cohort of 22 consecutive patients enrolled in a multicenter study. Surgery was bilateral in 17 and unilateral in five patients. At 6-month follow-up, the bilaterally GPi-implanted patients demonstrated a marked improvement when examined after drug withdrawal ("off") and under optimal medication ("on") using the Unified Parkinson's Disease Rating Scale (UPDRS). The benefit induced by the stimulation in the "off" medication condition in the total motor score was 31% and in the activities of daily living (ADL) scores was 39%. During the "on" medication period, the reduction in the total "on" dyskinesias score was 66% and in the ADL score was 32%. A similar pattern of improvement was seen in the group of patients with unilateral GPi stimulation, although a second cohort of 12 patients not included in the multicenter study showed greater improvements in "on" motor functioning. Although the effect of DBS is predominantly reversible, electrode insertion alone resulted in measurable clinical effects in the absence of stimulation. Thus, at 6-month follow-up, the benefit observed without stimulation was up to 44% in the "on" dyskinesias score and 29% in timed tapping scores undertaken in the "off" medication state. Complications among 34 patients from all centers included perioperative infection (n=3), hardware fracture (n=2), and premature battery failure (n=3). These results show a positive antiparkinsonian effect of pallidal DBS. No specific complications were observed with bilateral procedures. s disease.
C02	`01`	`X`		`@0 002B17G`
C03	`01`	`X`	`FRE`	`@0 Parkinson maladie @5 01`
C03	`01`	`X`	`ENG`	`@0 Parkinson disease @5 01`
C03	`01`	`X`	`SPA`	`@0 Parkinson enfermedad @5 01`
C03	`02`	`X`	`FRE`	`@0 Stimulation instrumentale @5 04`
C03	`02`	`X`	`ENG`	`@0 Instrumental stimulation @5 04`
C03	`02`	`X`	`SPA`	`@0 Estimulación instrumental @5 04`
C03	`03`	`X`	`FRE`	`@0 Encéphale @5 05`
C03	`03`	`X`	`ENG`	`@0 Brain (vertebrata) @5 05`
C03	`03`	`X`	`SPA`	`@0 Encéfalo @5 05`
C03	`04`	`X`	`FRE`	`@0 Pallidum @5 07`
C03	`04`	`X`	`ENG`	`@0 Pallidum @5 07`
C03	`04`	`X`	`SPA`	`@0 Pallidum @5 07`
C03	`05`	`X`	`FRE`	`@0 Traitement @5 17`
C03	`05`	`X`	`ENG`	`@0 Treatment @5 17`
C03	`05`	`X`	`SPA`	`@0 Tratamiento @5 17`
C03	`06`	`X`	`FRE`	`@0 Homme @5 20`
C03	`06`	`X`	`ENG`	`@0 Human @5 20`
C03	`06`	`X`	`SPA`	`@0 Hombre @5 20`
C07	`01`	`X`	`FRE`	`@0 Système nerveux pathologie @5 37`
C07	`01`	`X`	`ENG`	`@0 Nervous system diseases @5 37`
C07	`01`	`X`	`SPA`	`@0 Sistema nervioso patología @5 37`
C07	`02`	`X`	`FRE`	`@0 Système nerveux central pathologie @5 38`
C07	`02`	`X`	`ENG`	`@0 Central nervous system disease @5 38`
C07	`02`	`X`	`SPA`	`@0 Sistema nervosio central patología @5 38`
C07	`03`	`X`	`FRE`	`@0 Encéphale pathologie @5 39`
C07	`03`	`X`	`ENG`	`@0 Cerebral disorder @5 39`
C07	`03`	`X`	`SPA`	`@0 Encéfalo patología @5 39`
C07	`04`	`X`	`FRE`	`@0 Extrapyramidal syndrome @5 40`
C07	`04`	`X`	`ENG`	`@0 Extrapyramidal syndrome @5 40`
C07	`04`	`X`	`SPA`	`@0 Extrapiramidal síndrome @5 40`
C07	`05`	`X`	`FRE`	`@0 Maladie dégénérative @5 41`
C07	`05`	`X`	`ENG`	`@0 Degenerative disease @5 41`
C07	`05`	`X`	`SPA`	`@0 Enfermedad degenerativa @5 41`
C07	`06`	`X`	`FRE`	`@0 Traitement instrumental @5 45`
C07	`06`	`X`	`ENG`	`@0 Instrumentation therapy @5 45`
C07	`06`	`X`	`SPA`	`@0 Tratamiento instrumental @5 45`
N21				`@1 071`

A30	`01`	`1`	`ENG`	`@1 DBS Deep Brain Stimulation. Meeting @3 Miami, Florida USA @4 1997-02`

Format Inist (serveur)

NO :	PASCAL 01-0106279 INIST
ET :	eep brain stimulation of the globus pallidus pars interna in advanced Parkinson's disease
AU :	KUMAR (R.); LANG (A. E.); RODRIGUEZ-OROZ (M. C.); LOZANO (A. M.); LIMOUSIN (P.); POLLAK (P.); BENABID (A. L.); GURIDI (J.); RAMOS (E.); VAN DER LINDEN (C.); VANDEWALLE (A.); CAEMAERT (J.); LANNOO (E.); VAN DEN ABBEELE (D.); VINGERHOETS (G.); WOLTERS (M.); OBESO (J. A.); OBESO (J. A.); BENABID (A.); KOLLER (W.)
AF :	Division of Neurology and Neurosurgery, University of Toronto Medical School Toronto/Ontario/Canada (1 aut., 2 aut., 4 aut.); Department of Neurology, Neuroscience Center, Clinica Universitaria and Medical School, University Navarra/Pamplona/Espagne (3 aut., 17 aut.); Service of Neurosurgery and Neurology, CHRV/Grenoble/France (5 aut., 6 aut., 7 aut.); Clinica Quiron/San Sebastian/Espagne (8 aut., 9 aut.); Departments of Neurosurgery and Neurology, University Hospital Ghent/Ghent/Belgique (10 aut., 11 aut., 12 aut., 13 aut., 14 aut., 15 aut., 16 aut.); Department of Neurology and Neurosurgery, Neuroscience Program, Clinica Universitaria and Medical School, University of Navarra/Pamplona/Espagne (1 aut.); University of Miami Medical Center, Department of Neurology/Miami, Florida/Etats-Unis (3 aut.)
DT :	Publication en série; Congrès; Niveau analytique
SO :	Neurology; ISSN 0028-3878; Coden NEURAI; Etats-Unis; Da. 2000; Vol. 55; No. 12 SUP6; S34-S39; Bibl. 32 ref.
LA :	Anglais
EA :	Article abstract-Pallidotomy is now widely performed for the treatment of advanced Parkinson's disease (PD). Preliminary reports of the effect of globus pallidus pars interna deep brain stimulation (GPi DBS) have also been promising. We have analyzed a cohort of 22 consecutive patients enrolled in a multicenter study. Surgery was bilateral in 17 and unilateral in five patients. At 6-month follow-up, the bilaterally GPi-implanted patients demonstrated a marked improvement when examined after drug withdrawal ("off") and under optimal medication ("on") using the Unified Parkinson's Disease Rating Scale (UPDRS). The benefit induced by the stimulation in the "off" medication condition in the total motor score was 31% and in the activities of daily living (ADL) scores was 39%. During the "on" medication period, the reduction in the total "on" dyskinesias score was 66% and in the ADL score was 32%. A similar pattern of improvement was seen in the group of patients with unilateral GPi stimulation, although a second cohort of 12 patients not included in the multicenter study showed greater improvements in "on" motor functioning. Although the effect of DBS is predominantly reversible, electrode insertion alone resulted in measurable clinical effects in the absence of stimulation. Thus, at 6-month follow-up, the benefit observed without stimulation was up to 44% in the "on" dyskinesias score and 29% in timed tapping scores undertaken in the "off" medication state. Complications among 34 patients from all centers included perioperative infection (n=3), hardware fracture (n=2), and premature battery failure (n=3). These results show a positive antiparkinsonian effect of pallidal DBS. No specific complications were observed with bilateral procedures. s disease.
CC :	002B17G
FD :	Parkinson maladie; Stimulation instrumentale; Encéphale; Pallidum; Traitement; Homme
FG :	Système nerveux pathologie; Système nerveux central pathologie; Encéphale pathologie; Extrapyramidal syndrome; Maladie dégénérative; Traitement instrumental
ED :	Parkinson disease; Instrumental stimulation; Brain (vertebrata); Pallidum; Treatment; Human
EG :	Nervous system diseases; Central nervous system disease; Cerebral disorder; Extrapyramidal syndrome; Degenerative disease; Instrumentation therapy
SD :	Parkinson enfermedad; Estimulación instrumental; Encéfalo; Pallidum; Tratamiento; Hombre
LO :	INIST-6345.354000093591920070
ID :	01-0106279

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Pascal:01-0106279

Le document en format XML

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<sourceDesc><biblStruct><analytic><title xml:lang="en" level="a">eep brain stimulation of the globus pallidus pars interna in advanced Parkinson's disease</title>
<author><name sortKey="Kumar, R" sort="Kumar, R" uniqKey="Kumar R" first="R." last="Kumar">R. Kumar</name>
<affiliation><inist:fA14 i1="01"><s1>Division of Neurology and Neurosurgery, University of Toronto Medical School Toronto</s1>
<s2>Ontario</s2>
<s3>CAN</s3>
<sZ>1 aut.</sZ>
<sZ>2 aut.</sZ>
<sZ>4 aut.</sZ>
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<series><title level="j" type="main">Neurology</title>
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<front><div type="abstract" xml:lang="en">Article abstract-Pallidotomy is now widely performed for the treatment of advanced Parkinson's disease (PD). Preliminary reports of the effect of globus pallidus pars interna deep brain stimulation (GPi DBS) have also been promising. We have analyzed a cohort of 22 consecutive patients enrolled in a multicenter study. Surgery was bilateral in 17 and unilateral in five patients. At 6-month follow-up, the bilaterally GPi-implanted patients demonstrated a marked improvement when examined after drug withdrawal ("off") and under optimal medication ("on") using the Unified Parkinson's Disease Rating Scale (UPDRS). The benefit induced by the stimulation in the "off" medication condition in the total motor score was 31% and in the activities of daily living (ADL) scores was 39%. During the "on" medication period, the reduction in the total "on" dyskinesias score was 66% and in the ADL score was 32%. A similar pattern of improvement was seen in the group of patients with unilateral GPi stimulation, although a second cohort of 12 patients not included in the multicenter study showed greater improvements in "on" motor functioning. Although the effect of DBS is predominantly reversible, electrode insertion alone resulted in measurable clinical effects in the absence of stimulation. Thus, at 6-month follow-up, the benefit observed without stimulation was up to 44% in the "on" dyskinesias score and 29% in timed tapping scores undertaken in the "off" medication state. Complications among 34 patients from all centers included perioperative infection (n=3), hardware fracture (n=2), and premature battery failure (n=3). These results show a positive antiparkinsonian effect of pallidal DBS. No specific complications were observed with bilateral procedures. s disease.</div>
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<fA08 i1="01" i2="1" l="ENG"><s1>eep brain stimulation of the globus pallidus pars interna in advanced Parkinson's disease</s1>
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<fA14 i1="01"><s1>Division of Neurology and Neurosurgery, University of Toronto Medical School Toronto</s1>
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<pR><fA30 i1="01" i2="1" l="ENG"><s1>DBS Deep Brain Stimulation. Meeting</s1>
<s3>Miami, Florida USA</s3>
<s4>1997-02</s4>
</fA30>
</pR>
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<server><NO>PASCAL 01-0106279 INIST</NO>
<ET>eep brain stimulation of the globus pallidus pars interna in advanced Parkinson's disease</ET>
<AU>KUMAR (R.); LANG (A. E.); RODRIGUEZ-OROZ (M. C.); LOZANO (A. M.); LIMOUSIN (P.); POLLAK (P.); BENABID (A. L.); GURIDI (J.); RAMOS (E.); VAN DER LINDEN (C.); VANDEWALLE (A.); CAEMAERT (J.); LANNOO (E.); VAN DEN ABBEELE (D.); VINGERHOETS (G.); WOLTERS (M.); OBESO (J. A.); OBESO (J. A.); BENABID (A.); KOLLER (W.)</AU>
<AF>Division of Neurology and Neurosurgery, University of Toronto Medical School Toronto/Ontario/Canada (1 aut., 2 aut., 4 aut.); Department of Neurology, Neuroscience Center, Clinica Universitaria and Medical School, University Navarra/Pamplona/Espagne (3 aut., 17 aut.); Service of Neurosurgery and Neurology, CHRV/Grenoble/France (5 aut., 6 aut., 7 aut.); Clinica Quiron/San Sebastian/Espagne (8 aut., 9 aut.); Departments of Neurosurgery and Neurology, University Hospital Ghent/Ghent/Belgique (10 aut., 11 aut., 12 aut., 13 aut., 14 aut., 15 aut., 16 aut.); Department of Neurology and Neurosurgery, Neuroscience Program, Clinica Universitaria and Medical School, University of Navarra/Pamplona/Espagne (1 aut.); University of Miami Medical Center, Department of Neurology/Miami, Florida/Etats-Unis (3 aut.)</AF>
<DT>Publication en série; Congrès; Niveau analytique</DT>
<SO>Neurology; ISSN 0028-3878; Coden NEURAI; Etats-Unis; Da. 2000; Vol. 55; No. 12 SUP6; S34-S39; Bibl. 32 ref.</SO>
<LA>Anglais</LA>
<EA>Article abstract-Pallidotomy is now widely performed for the treatment of advanced Parkinson's disease (PD). Preliminary reports of the effect of globus pallidus pars interna deep brain stimulation (GPi DBS) have also been promising. We have analyzed a cohort of 22 consecutive patients enrolled in a multicenter study. Surgery was bilateral in 17 and unilateral in five patients. At 6-month follow-up, the bilaterally GPi-implanted patients demonstrated a marked improvement when examined after drug withdrawal ("off") and under optimal medication ("on") using the Unified Parkinson's Disease Rating Scale (UPDRS). The benefit induced by the stimulation in the "off" medication condition in the total motor score was 31% and in the activities of daily living (ADL) scores was 39%. During the "on" medication period, the reduction in the total "on" dyskinesias score was 66% and in the ADL score was 32%. A similar pattern of improvement was seen in the group of patients with unilateral GPi stimulation, although a second cohort of 12 patients not included in the multicenter study showed greater improvements in "on" motor functioning. Although the effect of DBS is predominantly reversible, electrode insertion alone resulted in measurable clinical effects in the absence of stimulation. Thus, at 6-month follow-up, the benefit observed without stimulation was up to 44% in the "on" dyskinesias score and 29% in timed tapping scores undertaken in the "off" medication state. Complications among 34 patients from all centers included perioperative infection (n=3), hardware fracture (n=2), and premature battery failure (n=3). These results show a positive antiparkinsonian effect of pallidal DBS. No specific complications were observed with bilateral procedures. s disease.</EA>
<CC>002B17G</CC>
<FD>Parkinson maladie; Stimulation instrumentale; Encéphale; Pallidum; Traitement; Homme</FD>
<FG>Système nerveux pathologie; Système nerveux central pathologie; Encéphale pathologie; Extrapyramidal syndrome; Maladie dégénérative; Traitement instrumental</FG>
<ED>Parkinson disease; Instrumental stimulation; Brain (vertebrata); Pallidum; Treatment; Human</ED>
<EG>Nervous system diseases; Central nervous system disease; Cerebral disorder; Extrapyramidal syndrome; Degenerative disease; Instrumentation therapy</EG>
<SD>Parkinson enfermedad; Estimulación instrumental; Encéfalo; Pallidum; Tratamiento; Hombre</SD>
<LO>INIST-6345.354000093591920070</LO>
<ID>01-0106279</ID>
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La maladie de Parkinson au Canada (serveur d'exploration)

eep brain stimulation of the globus pallidus pars interna in advanced Parkinson's disease

eep brain stimulation of the globus pallidus pars interna in advanced Parkinson's disease

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