Epidemiologic study of 203 sibling pairs with Parkinson's disease: The GenePD study
Identifieur interne : 000C04 ( PascalFrancis/Corpus ); précédent : 000C03; suivant : 000C05Epidemiologic study of 203 sibling pairs with Parkinson's disease: The GenePD study
Auteurs : N. E. Maher ; L. I. Golbe ; A. M. Lazzarini ; M. H. Mark ; L. J. Currie ; G. F. Wooten ; M. Saint-Hilaire ; J. B. Wilk ; J. Volcjak ; J. E. Maher ; R. G. Feldman ; M. Guttman ; M. Lew ; S. Schuman ; O. Suchowersky ; A. L. Lafontaine ; N. Labelle ; P. Vieregge ; P. P. Pramstaller ; C. Klein ; J. Hubble ; C. Reider ; J. Growdon ; R. Watts ; E. Montgomery ; K. Baker ; C. Singer ; M. Stacy ; R. H. MyersSource :
- Neurology [ 0028-3878 ] ; 2002.
Descripteurs français
- Pascal (Inist)
English descriptors
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Abstract
Objective: To examine patterns of familial aggregation and factors influencing onset age in a sample of siblings with PD. Methods: Sibling pairs (n = 203) with PD were collected as part of the GenePD study. Standardized family history, medical history, and risk factor data were collected and analyzed. Results: The mean age at onset was 61.4 years and did not differ according to sex, exposure to coffee, alcohol, or pesticides. Head trauma was associated with younger onset (p = 0.03) and multivitamin use with later onset (p = 0.007). Age at onset correlation between sibling pairs was significant (r = 0.56, p = 0.001) and was larger than the correlation in year of onset (r = 0.29). The mean difference in onset age between siblings was 8.7 years (range, 0 to 30 years). Female sex was associated with increased frequency of relatives with PD. The frequency of affected parents (7.0%) and siblings (5.1%) was increased when compared with frequency in spouses (2.0%). Conclusions: The greater similarity for age at onset than for year of onset in sibling pairs with PD, together with increased risk for biological relatives over spouses of cases, supports a genetic component for PD. Risk to siblings in this series is increased over that seen in random series of PD cases; however, patients in this sample have similar ages at onset and sex distribution as seen for PD generally. These analyses suggest that factors influencing penetrance are critical to the understanding of this disease.
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| NO : | PASCAL 02-0118878 INIST |
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| ET : | Epidemiologic study of 203 sibling pairs with Parkinson's disease: The GenePD study |
| AU : | MAHER (N. E.); GOLBE (L. I.); LAZZARINI (A. M.); MARK (M. H.); CURRIE (L. J.); WOOTEN (G. F.); SAINT-HILAIRE (M.); WILK (J. B.); VOLCJAK (J.); MAHER (J. E.); FELDMAN (R. G.); GUTTMAN (M.); LEW (M.); SCHUMAN (S.); SUCHOWERSKY (O.); LAFONTAINE (A. L.); LABELLE (N.); VIEREGGE (P.); PRAMSTALLER (P. P.); KLEIN (C.); HUBBLE (J.); REIDER (C.); GROWDON (J.); WATTS (R.); MONTGOMERY (E.); BAKER (K.); SINGER (C.); STACY (M.); MYERS (R. H.) |
| AF : | Department of Neurology, Boston University School of Medicine/MA/Etats-Unis; Department of Neurology, University of Medicine and Dentistry of New Jersey-Robert Wood Johnson Medical School/New Brunswick/Etats-Unis; Department of Neurology, University of Virginia Health System/Charlottesville/Etats-Unis; Division of Neurology, Department of Medicine, University of Toronto/Ontario/Canada; Department of Neurology, University of Southern California/Los Angeles/Etats-Unis; Departments of Clinical Neurosciences and Medical Genetics, University of Calgary/Alberta/Canada; Department of Neurology, Medical University of Lübeck/Allemagne; Department of Neurology, General Regional Hospital Bolzano/Italie; Department of Neurology, Ohio State University/Columbus/Etats-Unis; Department of Neurology Massachusetts General Hospital, Harvard Medical School/Boston/Etats-Unis; Department of Neurology, Emory University/Atlanta, GA/Etats-Unis; Departments of Neurology and Neuroscience, Cleveland Clinic Foundation/OH/Etats-Unis; Department of Neurology, University of Miami/FL/Etats-Unis; Department of Neurology, Barrow Clinic/Phoenix, AZ/Etats-Unis |
| DT : | Publication en série; Niveau analytique |
| SO : | Neurology; ISSN 0028-3878; Coden NEURAI; Etats-Unis; Da. 2002; Vol. 58; No. 1; Pp. 79-84; Bibl. 54 ref. |
| LA : | Anglais |
| EA : | Objective: To examine patterns of familial aggregation and factors influencing onset age in a sample of siblings with PD. Methods: Sibling pairs (n = 203) with PD were collected as part of the GenePD study. Standardized family history, medical history, and risk factor data were collected and analyzed. Results: The mean age at onset was 61.4 years and did not differ according to sex, exposure to coffee, alcohol, or pesticides. Head trauma was associated with younger onset (p = 0.03) and multivitamin use with later onset (p = 0.007). Age at onset correlation between sibling pairs was significant (r = 0.56, p = 0.001) and was larger than the correlation in year of onset (r = 0.29). The mean difference in onset age between siblings was 8.7 years (range, 0 to 30 years). Female sex was associated with increased frequency of relatives with PD. The frequency of affected parents (7.0%) and siblings (5.1%) was increased when compared with frequency in spouses (2.0%). Conclusions: The greater similarity for age at onset than for year of onset in sibling pairs with PD, together with increased risk for biological relatives over spouses of cases, supports a genetic component for PD. Risk to siblings in this series is increased over that seen in random series of PD cases; however, patients in this sample have similar ages at onset and sex distribution as seen for PD generally. These analyses suggest that factors influencing penetrance are critical to the understanding of this disease. |
| CC : | 002B17G |
| FD : | Parkinson maladie; Age apparition; Agrégation; Phénotype; Déterminisme génétique; Epidémiologie; Fratrie; Facteur risque; Homme |
| FG : | Système nerveux pathologie; Système nerveux central pathologie; Encéphale pathologie; Extrapyramidal syndrome; Maladie dégénérative; Maladie héréditaire |
| ED : | Parkinson disease; Age of onset; Aggregation; Phenotype; Genetic determinism; Epidemiology; Sibling; Risk factor; Human |
| EG : | Nervous system diseases; Central nervous system disease; Cerebral disorder; Extrapyramidal syndrome; Degenerative disease; Genetic disease |
| SD : | Parkinson enfermedad; Edad aparición; Agregación; Fenotipo; Determinismo genético; Epidemiología; Hermandad; Factor riesgo; Hombre |
| LO : | INIST-6345.354000094698500120 |
| ID : | 02-0118878 |
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Growdon</name></author><author><name sortKey="Watts, R" sort="Watts, R" uniqKey="Watts R" first="R." last="Watts">R. Watts</name></author><author><name sortKey="Montgomery, E" sort="Montgomery, E" uniqKey="Montgomery E" first="E." last="Montgomery">E. Montgomery</name></author><author><name sortKey="Baker, K" sort="Baker, K" uniqKey="Baker K" first="K." last="Baker">K. Baker</name></author><author><name sortKey="Singer, C" sort="Singer, C" uniqKey="Singer C" first="C." last="Singer">C. Singer</name></author><author><name sortKey="Stacy, M" sort="Stacy, M" uniqKey="Stacy M" first="M." last="Stacy">M. Stacy</name></author><author><name sortKey="Myers, R H" sort="Myers, R H" uniqKey="Myers R" first="R. H." last="Myers">R. H. Myers</name></author></titleStmt><publicationStmt><idno type="wicri:source">INIST</idno><idno type="inist">02-0118878</idno><date when="2002">2002</date><idno type="stanalyst">PASCAL 02-0118878 INIST</idno><idno type="RBID">Pascal:02-0118878</idno><idno type="wicri:Area/PascalFrancis/Corpus">000C04</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en" level="a">Epidemiologic study of 203 sibling pairs with Parkinson's disease: The GenePD study</title><author><name sortKey="Maher, N E" sort="Maher, N E" uniqKey="Maher N" first="N. E." last="Maher">N. E. Maher</name><affiliation><inist:fA14 i1="01"><s1>Department of Neurology, Boston University School of Medicine</s1><s2>MA</s2><s3>USA</s3></inist:fA14></affiliation><affiliation><inist:fA14 i1="02"><s1>Department of Neurology, University of Medicine and Dentistry of New Jersey-Robert Wood Johnson Medical School</s1><s2>New Brunswick</s2><s3>USA</s3></inist:fA14></affiliation><affiliation><inist:fA14 i1="03"><s1>Department of Neurology, University of Virginia Health System</s1><s2>Charlottesville</s2><s3>USA</s3></inist:fA14></affiliation><affiliation><inist:fA14 i1="04"><s1>Division of Neurology, Department of Medicine, University of Toronto</s1><s2>Ontario</s2><s3>CAN</s3></inist:fA14></affiliation><affiliation><inist:fA14 i1="05"><s1>Department of Neurology, University of Southern California</s1><s2>Los Angeles</s2><s3>USA</s3></inist:fA14></affiliation><affiliation><inist:fA14 i1="06"><s1>Departments of Clinical Neurosciences and Medical Genetics, University of Calgary</s1><s2>Alberta</s2><s3>CAN</s3></inist:fA14></affiliation><affiliation><inist:fA14 i1="07"><s1>Department of Neurology, Medical University of Lübeck</s1><s3>DEU</s3></inist:fA14></affiliation><affiliation><inist:fA14 i1="08"><s1>Department of Neurology, General Regional Hospital Bolzano</s1><s3>ITA</s3></inist:fA14></affiliation><affiliation><inist:fA14 i1="09"><s1>Department of Neurology, Ohio State University</s1><s2>Columbus</s2><s3>USA</s3></inist:fA14></affiliation><affiliation><inist:fA14 i1="10"><s1>Department of Neurology Massachusetts General Hospital, Harvard Medical School</s1><s2>Boston</s2><s3>USA</s3></inist:fA14></affiliation><affiliation><inist:fA14 i1="11"><s1>Department of Neurology, Emory University</s1><s2>Atlanta, GA</s2><s3>USA</s3></inist:fA14></affiliation><affiliation><inist:fA14 i1="12"><s1>Departments of Neurology and Neuroscience, Cleveland Clinic Foundation</s1><s2>OH</s2><s3>USA</s3></inist:fA14></affiliation><affiliation><inist:fA14 i1="13"><s1>Department of Neurology, University of Miami</s1><s2>FL</s2><s3>USA</s3></inist:fA14></affiliation><affiliation><inist:fA14 i1="14"><s1>Department of Neurology, Barrow Clinic</s1><s2>Phoenix, AZ</s2><s3>USA</s3></inist:fA14></affiliation></author><author><name sortKey="Golbe, L I" sort="Golbe, L I" uniqKey="Golbe L" first="L. I." last="Golbe">L. I. Golbe</name></author><author><name sortKey="Lazzarini, A M" sort="Lazzarini, A M" uniqKey="Lazzarini A" first="A. M." last="Lazzarini">A. M. Lazzarini</name></author><author><name sortKey="Mark, M H" sort="Mark, M H" uniqKey="Mark M" first="M. H." last="Mark">M. H. Mark</name></author><author><name sortKey="Currie, L J" sort="Currie, L J" uniqKey="Currie L" first="L. J." last="Currie">L. J. Currie</name></author><author><name sortKey="Wooten, G F" sort="Wooten, G F" uniqKey="Wooten G" first="G. F." last="Wooten">G. F. Wooten</name></author><author><name sortKey="Saint Hilaire, M" sort="Saint Hilaire, M" uniqKey="Saint Hilaire M" first="M." last="Saint-Hilaire">M. Saint-Hilaire</name></author><author><name sortKey="Wilk, J B" sort="Wilk, J B" uniqKey="Wilk J" first="J. B." last="Wilk">J. B. Wilk</name></author><author><name sortKey="Volcjak, J" sort="Volcjak, J" uniqKey="Volcjak J" first="J." last="Volcjak">J. Volcjak</name></author><author><name sortKey="Maher, J E" sort="Maher, J E" uniqKey="Maher J" first="J. E." last="Maher">J. E. Maher</name></author><author><name sortKey="Feldman, R G" sort="Feldman, R G" uniqKey="Feldman R" first="R. G." last="Feldman">R. G. Feldman</name></author><author><name sortKey="Guttman, M" sort="Guttman, M" uniqKey="Guttman M" first="M." last="Guttman">M. Guttman</name></author><author><name sortKey="Lew, M" sort="Lew, M" uniqKey="Lew M" first="M." last="Lew">M. Lew</name></author><author><name sortKey="Schuman, S" sort="Schuman, S" uniqKey="Schuman S" first="S." last="Schuman">S. Schuman</name></author><author><name sortKey="Suchowersky, O" sort="Suchowersky, O" uniqKey="Suchowersky O" first="O." last="Suchowersky">O. Suchowersky</name></author><author><name sortKey="Lafontaine, A L" sort="Lafontaine, A L" uniqKey="Lafontaine A" first="A. L." last="Lafontaine">A. L. Lafontaine</name></author><author><name sortKey="Labelle, N" sort="Labelle, N" uniqKey="Labelle N" first="N." last="Labelle">N. Labelle</name></author><author><name sortKey="Vieregge, P" sort="Vieregge, P" uniqKey="Vieregge P" first="P." last="Vieregge">P. Vieregge</name></author><author><name sortKey="Pramstaller, P P" sort="Pramstaller, P P" uniqKey="Pramstaller P" first="P. P." last="Pramstaller">P. P. Pramstaller</name></author><author><name sortKey="Klein, C" sort="Klein, C" uniqKey="Klein C" first="C." last="Klein">C. Klein</name></author><author><name sortKey="Hubble, J" sort="Hubble, J" uniqKey="Hubble J" first="J." last="Hubble">J. Hubble</name></author><author><name sortKey="Reider, C" sort="Reider, C" uniqKey="Reider C" first="C." last="Reider">C. Reider</name></author><author><name sortKey="Growdon, J" sort="Growdon, J" uniqKey="Growdon J" first="J." last="Growdon">J. Growdon</name></author><author><name sortKey="Watts, R" sort="Watts, R" uniqKey="Watts R" first="R." last="Watts">R. Watts</name></author><author><name sortKey="Montgomery, E" sort="Montgomery, E" uniqKey="Montgomery E" first="E." last="Montgomery">E. Montgomery</name></author><author><name sortKey="Baker, K" sort="Baker, K" uniqKey="Baker K" first="K." last="Baker">K. Baker</name></author><author><name sortKey="Singer, C" sort="Singer, C" uniqKey="Singer C" first="C." last="Singer">C. Singer</name></author><author><name sortKey="Stacy, M" sort="Stacy, M" uniqKey="Stacy M" first="M." last="Stacy">M. Stacy</name></author><author><name sortKey="Myers, R H" sort="Myers, R H" uniqKey="Myers R" first="R. H." last="Myers">R. H. Myers</name></author></analytic><series><title level="j" type="main">Neurology</title><title level="j" type="abbreviated">Neurology</title><idno type="ISSN">0028-3878</idno><imprint><date when="2002">2002</date></imprint></series></biblStruct></sourceDesc><seriesStmt><title level="j" type="main">Neurology</title><title level="j" type="abbreviated">Neurology</title><idno type="ISSN">0028-3878</idno></seriesStmt></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Age of onset</term><term>Aggregation</term><term>Epidemiology</term><term>Genetic determinism</term><term>Human</term><term>Parkinson disease</term><term>Phenotype</term><term>Risk factor</term><term>Sibling</term></keywords><keywords scheme="Pascal" xml:lang="fr"><term>Parkinson maladie</term><term>Age apparition</term><term>Agrégation</term><term>Phénotype</term><term>Déterminisme génétique</term><term>Epidémiologie</term><term>Fratrie</term><term>Facteur risque</term><term>Homme</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">Objective: To examine patterns of familial aggregation and factors influencing onset age in a sample of siblings with PD. Methods: Sibling pairs (n = 203) with PD were collected as part of the GenePD study. Standardized family history, medical history, and risk factor data were collected and analyzed. Results: The mean age at onset was 61.4 years and did not differ according to sex, exposure to coffee, alcohol, or pesticides. Head trauma was associated with younger onset (p = 0.03) and multivitamin use with later onset (p = 0.007). Age at onset correlation between sibling pairs was significant (r = 0.56, p = 0.001) and was larger than the correlation in year of onset (r = 0.29). The mean difference in onset age between siblings was 8.7 years (range, 0 to 30 years). Female sex was associated with increased frequency of relatives with PD. The frequency of affected parents (7.0%) and siblings (5.1%) was increased when compared with frequency in spouses (2.0%). Conclusions: The greater similarity for age at onset than for year of onset in sibling pairs with PD, together with increased risk for biological relatives over spouses of cases, supports a genetic component for PD. Risk to siblings in this series is increased over that seen in random series of PD cases; however, patients in this sample have similar ages at onset and sex distribution as seen for PD generally. These analyses suggest that factors influencing penetrance are critical to the understanding of this disease.</div></front></TEI><inist><standard h6="B"><pA><fA01 i1="01" i2="1"><s0>0028-3878</s0></fA01><fA02 i1="01"><s0>NEURAI</s0></fA02><fA03 i2="1"><s0>Neurology</s0></fA03><fA05><s2>58</s2></fA05><fA06><s2>1</s2></fA06><fA08 i1="01" i2="1" l="ENG"><s1>Epidemiologic study of 203 sibling pairs with Parkinson's disease: The GenePD study</s1></fA08><fA11 i1="01" i2="1"><s1>MAHER (N. E.)</s1></fA11><fA11 i1="02" i2="1"><s1>GOLBE (L. I.)</s1></fA11><fA11 i1="03" i2="1"><s1>LAZZARINI (A. M.)</s1></fA11><fA11 i1="04" i2="1"><s1>MARK (M. H.)</s1></fA11><fA11 i1="05" i2="1"><s1>CURRIE (L. J.)</s1></fA11><fA11 i1="06" i2="1"><s1>WOOTEN (G. F.)</s1></fA11><fA11 i1="07" i2="1"><s1>SAINT-HILAIRE (M.)</s1></fA11><fA11 i1="08" i2="1"><s1>WILK (J. B.)</s1></fA11><fA11 i1="09" i2="1"><s1>VOLCJAK (J.)</s1></fA11><fA11 i1="10" i2="1"><s1>MAHER (J. E.)</s1></fA11><fA11 i1="11" i2="1"><s1>FELDMAN (R. G.)</s1></fA11><fA11 i1="12" i2="1"><s1>GUTTMAN (M.)</s1></fA11><fA11 i1="13" i2="1"><s1>LEW (M.)</s1></fA11><fA11 i1="14" i2="1"><s1>SCHUMAN (S.)</s1></fA11><fA11 i1="15" i2="1"><s1>SUCHOWERSKY (O.)</s1></fA11><fA11 i1="16" i2="1"><s1>LAFONTAINE (A. L.)</s1></fA11><fA11 i1="17" i2="1"><s1>LABELLE (N.)</s1></fA11><fA11 i1="18" i2="1"><s1>VIEREGGE (P.)</s1></fA11><fA11 i1="19" i2="1"><s1>PRAMSTALLER (P. P.)</s1></fA11><fA11 i1="20" i2="1"><s1>KLEIN (C.)</s1></fA11><fA11 i1="21" i2="1"><s1>HUBBLE (J.)</s1></fA11><fA11 i1="22" i2="1"><s1>REIDER (C.)</s1></fA11><fA11 i1="23" i2="1"><s1>GROWDON (J.)</s1></fA11><fA11 i1="24" i2="1"><s1>WATTS (R.)</s1></fA11><fA11 i1="25" i2="1"><s1>MONTGOMERY (E.)</s1></fA11><fA11 i1="26" i2="1"><s1>BAKER (K.)</s1></fA11><fA11 i1="27" i2="1"><s1>SINGER (C.)</s1></fA11><fA11 i1="28" i2="1"><s1>STACY (M.)</s1></fA11><fA11 i1="29" i2="1"><s1>MYERS (R. H.)</s1></fA11><fA14 i1="01"><s1>Department of Neurology, Boston University School of Medicine</s1><s2>MA</s2><s3>USA</s3></fA14><fA14 i1="02"><s1>Department of Neurology, University of Medicine and Dentistry of New Jersey-Robert Wood Johnson Medical School</s1><s2>New Brunswick</s2><s3>USA</s3></fA14><fA14 i1="03"><s1>Department of Neurology, University of Virginia Health System</s1><s2>Charlottesville</s2><s3>USA</s3></fA14><fA14 i1="04"><s1>Division of Neurology, Department of Medicine, University of Toronto</s1><s2>Ontario</s2><s3>CAN</s3></fA14><fA14 i1="05"><s1>Department of Neurology, University of Southern California</s1><s2>Los Angeles</s2><s3>USA</s3></fA14><fA14 i1="06"><s1>Departments of Clinical Neurosciences and Medical Genetics, University of Calgary</s1><s2>Alberta</s2><s3>CAN</s3></fA14><fA14 i1="07"><s1>Department of Neurology, Medical University of Lübeck</s1><s3>DEU</s3></fA14><fA14 i1="08"><s1>Department of Neurology, General Regional Hospital Bolzano</s1><s3>ITA</s3></fA14><fA14 i1="09"><s1>Department of Neurology, Ohio State University</s1><s2>Columbus</s2><s3>USA</s3></fA14><fA14 i1="10"><s1>Department of Neurology Massachusetts General Hospital, Harvard Medical School</s1><s2>Boston</s2><s3>USA</s3></fA14><fA14 i1="11"><s1>Department of Neurology, Emory University</s1><s2>Atlanta, GA</s2><s3>USA</s3></fA14><fA14 i1="12"><s1>Departments of Neurology and Neuroscience, Cleveland Clinic Foundation</s1><s2>OH</s2><s3>USA</s3></fA14><fA14 i1="13"><s1>Department of Neurology, University of Miami</s1><s2>FL</s2><s3>USA</s3></fA14><fA14 i1="14"><s1>Department of Neurology, Barrow Clinic</s1><s2>Phoenix, AZ</s2><s3>USA</s3></fA14><fA20><s1>79-84</s1></fA20><fA21><s1>2002</s1></fA21><fA23 i1="01"><s0>ENG</s0></fA23><fA43 i1="01"><s1>INIST</s1><s2>6345</s2><s5>354000094698500120</s5></fA43><fA44><s0>0000</s0><s1>© 2002 INIST-CNRS. All rights reserved.</s1></fA44><fA45><s0>54 ref.</s0></fA45><fA47 i1="01" i2="1"><s0>02-0118878</s0></fA47><fA60><s1>P</s1></fA60><fA61><s0>A</s0></fA61><fA64 i1="01" i2="1"><s0>Neurology</s0></fA64><fA66 i1="01"><s0>USA</s0></fA66><fC01 i1="01" l="ENG"><s0>Objective: To examine patterns of familial aggregation and factors influencing onset age in a sample of siblings with PD. Methods: Sibling pairs (n = 203) with PD were collected as part of the GenePD study. Standardized family history, medical history, and risk factor data were collected and analyzed. Results: The mean age at onset was 61.4 years and did not differ according to sex, exposure to coffee, alcohol, or pesticides. Head trauma was associated with younger onset (p = 0.03) and multivitamin use with later onset (p = 0.007). Age at onset correlation between sibling pairs was significant (r = 0.56, p = 0.001) and was larger than the correlation in year of onset (r = 0.29). The mean difference in onset age between siblings was 8.7 years (range, 0 to 30 years). Female sex was associated with increased frequency of relatives with PD. The frequency of affected parents (7.0%) and siblings (5.1%) was increased when compared with frequency in spouses (2.0%). Conclusions: The greater similarity for age at onset than for year of onset in sibling pairs with PD, together with increased risk for biological relatives over spouses of cases, supports a genetic component for PD. Risk to siblings in this series is increased over that seen in random series of PD cases; however, patients in this sample have similar ages at onset and sex distribution as seen for PD generally. These analyses suggest that factors influencing penetrance are critical to the understanding of this disease.</s0></fC01><fC02 i1="01" i2="X"><s0>002B17G</s0></fC02><fC03 i1="01" i2="X" l="FRE"><s0>Parkinson maladie</s0><s5>01</s5></fC03><fC03 i1="01" i2="X" l="ENG"><s0>Parkinson disease</s0><s5>01</s5></fC03><fC03 i1="01" i2="X" l="SPA"><s0>Parkinson enfermedad</s0><s5>01</s5></fC03><fC03 i1="02" i2="X" l="FRE"><s0>Age apparition</s0><s5>04</s5></fC03><fC03 i1="02" i2="X" l="ENG"><s0>Age of onset</s0><s5>04</s5></fC03><fC03 i1="02" i2="X" l="SPA"><s0>Edad aparición</s0><s5>04</s5></fC03><fC03 i1="03" i2="X" l="FRE"><s0>Agrégation</s0><s5>07</s5></fC03><fC03 i1="03" i2="X" l="ENG"><s0>Aggregation</s0><s5>07</s5></fC03><fC03 i1="03" i2="X" l="SPA"><s0>Agregación</s0><s5>07</s5></fC03><fC03 i1="04" i2="X" l="FRE"><s0>Phénotype</s0><s5>10</s5></fC03><fC03 i1="04" i2="X" l="ENG"><s0>Phenotype</s0><s5>10</s5></fC03><fC03 i1="04" i2="X" l="SPA"><s0>Fenotipo</s0><s5>10</s5></fC03><fC03 i1="05" i2="X" l="FRE"><s0>Déterminisme génétique</s0><s5>16</s5></fC03><fC03 i1="05" i2="X" l="ENG"><s0>Genetic determinism</s0><s5>16</s5></fC03><fC03 i1="05" i2="X" l="SPA"><s0>Determinismo genético</s0><s5>16</s5></fC03><fC03 i1="06" i2="X" l="FRE"><s0>Epidémiologie</s0><s5>17</s5></fC03><fC03 i1="06" i2="X" l="ENG"><s0>Epidemiology</s0><s5>17</s5></fC03><fC03 i1="06" i2="X" l="SPA"><s0>Epidemiología</s0><s5>17</s5></fC03><fC03 i1="07" i2="X" l="FRE"><s0>Fratrie</s0><s5>18</s5></fC03><fC03 i1="07" i2="X" l="ENG"><s0>Sibling</s0><s5>18</s5></fC03><fC03 i1="07" i2="X" l="SPA"><s0>Hermandad</s0><s5>18</s5></fC03><fC03 i1="08" i2="X" l="FRE"><s0>Facteur risque</s0><s5>19</s5></fC03><fC03 i1="08" i2="X" l="ENG"><s0>Risk factor</s0><s5>19</s5></fC03><fC03 i1="08" i2="X" l="SPA"><s0>Factor riesgo</s0><s5>19</s5></fC03><fC03 i1="09" i2="X" l="FRE"><s0>Homme</s0><s5>20</s5></fC03><fC03 i1="09" i2="X" l="ENG"><s0>Human</s0><s5>20</s5></fC03><fC03 i1="09" i2="X" l="SPA"><s0>Hombre</s0><s5>20</s5></fC03><fC07 i1="01" i2="X" l="FRE"><s0>Système nerveux pathologie</s0><s5>37</s5></fC07><fC07 i1="01" i2="X" l="ENG"><s0>Nervous system diseases</s0><s5>37</s5></fC07><fC07 i1="01" i2="X" l="SPA"><s0>Sistema nervioso patología</s0><s5>37</s5></fC07><fC07 i1="02" i2="X" l="FRE"><s0>Système nerveux central pathologie</s0><s5>38</s5></fC07><fC07 i1="02" i2="X" l="ENG"><s0>Central nervous system disease</s0><s5>38</s5></fC07><fC07 i1="02" i2="X" l="SPA"><s0>Sistema nervosio central patología</s0><s5>38</s5></fC07><fC07 i1="03" i2="X" l="FRE"><s0>Encéphale pathologie</s0><s5>39</s5></fC07><fC07 i1="03" i2="X" l="ENG"><s0>Cerebral disorder</s0><s5>39</s5></fC07><fC07 i1="03" i2="X" l="SPA"><s0>Encéfalo patología</s0><s5>39</s5></fC07><fC07 i1="04" i2="X" l="FRE"><s0>Extrapyramidal syndrome</s0><s5>40</s5></fC07><fC07 i1="04" i2="X" l="ENG"><s0>Extrapyramidal syndrome</s0><s5>40</s5></fC07><fC07 i1="04" i2="X" l="SPA"><s0>Extrapiramidal síndrome</s0><s5>40</s5></fC07><fC07 i1="05" i2="X" l="FRE"><s0>Maladie dégénérative</s0><s5>41</s5></fC07><fC07 i1="05" i2="X" l="ENG"><s0>Degenerative disease</s0><s5>41</s5></fC07><fC07 i1="05" i2="X" l="SPA"><s0>Enfermedad degenerativa</s0><s5>41</s5></fC07><fC07 i1="06" i2="X" l="FRE"><s0>Maladie héréditaire</s0><s5>42</s5></fC07><fC07 i1="06" i2="X" l="ENG"><s0>Genetic disease</s0><s5>42</s5></fC07><fC07 i1="06" i2="X" l="SPA"><s0>Enfermedad hereditaria</s0><s5>42</s5></fC07><fN21><s1>063</s1></fN21><fN82><s1>PSI</s1></fN82></pA></standard><server><NO>PASCAL 02-0118878 INIST</NO><ET>Epidemiologic study of 203 sibling pairs with Parkinson's disease: The GenePD study</ET><AU>MAHER (N. E.); GOLBE (L. I.); LAZZARINI (A. M.); MARK (M. H.); CURRIE (L. J.); WOOTEN (G. F.); SAINT-HILAIRE (M.); WILK (J. B.); VOLCJAK (J.); MAHER (J. E.); FELDMAN (R. G.); GUTTMAN (M.); LEW (M.); SCHUMAN (S.); SUCHOWERSKY (O.); LAFONTAINE (A. L.); LABELLE (N.); VIEREGGE (P.); PRAMSTALLER (P. P.); KLEIN (C.); HUBBLE (J.); REIDER (C.); GROWDON (J.); WATTS (R.); MONTGOMERY (E.); BAKER (K.); SINGER (C.); STACY (M.); MYERS (R. H.)</AU><AF>Department of Neurology, Boston University School of Medicine/MA/Etats-Unis; Department of Neurology, University of Medicine and Dentistry of New Jersey-Robert Wood Johnson Medical School/New Brunswick/Etats-Unis; Department of Neurology, University of Virginia Health System/Charlottesville/Etats-Unis; Division of Neurology, Department of Medicine, University of Toronto/Ontario/Canada; Department of Neurology, University of Southern California/Los Angeles/Etats-Unis; Departments of Clinical Neurosciences and Medical Genetics, University of Calgary/Alberta/Canada; Department of Neurology, Medical University of Lübeck/Allemagne; Department of Neurology, General Regional Hospital Bolzano/Italie; Department of Neurology, Ohio State University/Columbus/Etats-Unis; Department of Neurology Massachusetts General Hospital, Harvard Medical School/Boston/Etats-Unis; Department of Neurology, Emory University/Atlanta, GA/Etats-Unis; Departments of Neurology and Neuroscience, Cleveland Clinic Foundation/OH/Etats-Unis; Department of Neurology, University of Miami/FL/Etats-Unis; Department of Neurology, Barrow Clinic/Phoenix, AZ/Etats-Unis</AF><DT>Publication en série; Niveau analytique</DT><SO>Neurology; ISSN 0028-3878; Coden NEURAI; Etats-Unis; Da. 2002; Vol. 58; No. 1; Pp. 79-84; Bibl. 54 ref.</SO><LA>Anglais</LA><EA>Objective: To examine patterns of familial aggregation and factors influencing onset age in a sample of siblings with PD. Methods: Sibling pairs (n = 203) with PD were collected as part of the GenePD study. Standardized family history, medical history, and risk factor data were collected and analyzed. Results: The mean age at onset was 61.4 years and did not differ according to sex, exposure to coffee, alcohol, or pesticides. Head trauma was associated with younger onset (p = 0.03) and multivitamin use with later onset (p = 0.007). Age at onset correlation between sibling pairs was significant (r = 0.56, p = 0.001) and was larger than the correlation in year of onset (r = 0.29). The mean difference in onset age between siblings was 8.7 years (range, 0 to 30 years). Female sex was associated with increased frequency of relatives with PD. The frequency of affected parents (7.0%) and siblings (5.1%) was increased when compared with frequency in spouses (2.0%). Conclusions: The greater similarity for age at onset than for year of onset in sibling pairs with PD, together with increased risk for biological relatives over spouses of cases, supports a genetic component for PD. Risk to siblings in this series is increased over that seen in random series of PD cases; however, patients in this sample have similar ages at onset and sex distribution as seen for PD generally. These analyses suggest that factors influencing penetrance are critical to the understanding of this disease.</EA><CC>002B17G</CC><FD>Parkinson maladie; Age apparition; Agrégation; Phénotype; Déterminisme génétique; Epidémiologie; Fratrie; Facteur risque; Homme</FD><FG>Système nerveux pathologie; Système nerveux central pathologie; Encéphale pathologie; Extrapyramidal syndrome; Maladie dégénérative; Maladie héréditaire</FG><ED>Parkinson disease; Age of onset; Aggregation; Phenotype; Genetic determinism; Epidemiology; Sibling; Risk factor; Human</ED><EG>Nervous system diseases; Central nervous system disease; Cerebral disorder; Extrapyramidal syndrome; Degenerative disease; Genetic disease</EG><SD>Parkinson enfermedad; Edad aparición; Agregación; Fenotipo; Determinismo genético; Epidemiología; Hermandad; Factor riesgo; Hombre</SD><LO>INIST-6345.354000094698500120</LO><ID>02-0118878</ID></server></inist></record>Pour manipuler ce document sous Unix (Dilib)
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