Role of serotonin2C receptors in the control of brain dopaminergic function
Identifieur interne : 000B74 ( PascalFrancis/Corpus ); précédent : 000B73; suivant : 000B75Role of serotonin2C receptors in the control of brain dopaminergic function
Auteurs : Vincenzo Di Matteo ; Marisa Cacchio ; Camillo Di Giulio ; Ennio EspositoSource :
- Pharmacology, biochemistry and behavior [ 0091-3057 ] ; 2002.
Descripteurs français
- Pascal (Inist)
- Récepteur sérotoninergique 5-HT2C, Rat, Homme, Etat dépressif, In vitro, In vivo, Schizophrénie, Parkinson maladie, Dépendance, Article synthèse, Sérotonine, Voie dopaminergique, Encéphale, Dopamine, Antagoniste, Agoniste, Système nerveux central, Aire tegmentaire ventrale, Locus niger, Voie nigrostriatale, Neuroleptique, Psychotrope, Animal, Voie mésolimbique, Antidépresseur.
English descriptors
- KwdEn :
- 5-HT2C serotonin receptor, Agonist, Animal, Antagonist, Antidepressant agent, Brain (vertebrata), Central nervous system, Dependence, Depression, Dopamine, Dopaminergic pathway, Human, In vitro, In vivo, Locus niger, Mesolimbic pathway, Neuroleptic, Nigrostriatal pathway, Parkinson disease, Psychotropic, Rat, Review, Schizophrenia, Serotonin, Ventral tegmental area.
Abstract
There is substantial evidence that the functional status of mesocorticolimbic dopaminergic (DA) system originating in the ventral tegmental area (VTA) is under a phasic and tonic inhibitory control by the serotonergic system, which acts by stimulating serotonin2C (5-HT2C) receptor subtypes. This assertion is based upon a number of electrophysiological and biochemical data showing that 5-HT2C receptor agonists decrease, while 5-HT2C receptor antagonists enhance mesocorticolimbic DA function. On the other hand, it does not seem that 5-HT2C receptors play a relevant role in the control of nigrostriatal DA system originating in the substantia nigra pars compacta (SNc). The authors of this article review the most relevant data regarding the role of 5-HT2C receptors in the control of brain DA function and underline the importance of this subject in the search of new therapies for neuropsychiatric disorders such as depression, schizophrenia, drug addiction, and Parkinson's disease.
Notice en format standard (ISO 2709)
Pour connaître la documentation sur le format Inist Standard.
pA |
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Format Inist (serveur)
NO : | PASCAL 02-0355643 INIST |
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ET : | Role of serotonin2C receptors in the control of brain dopaminergic function |
AU : | DI MATTEO (Vincenzo); CACCHIO (Marisa); DI GIULIO (Camillo); ESPOSITO (Ennio); HIGGINS (Guy A.); FLETCHER (Paul J.) |
AF : | Istituto di Ricerche Farmacologiche "Mario Negri", Consorzio "Mario Negri" Sud/66030 Santa Maria Imbaro, Chieti/Italie (1 aut., 4 aut.); Department of Biomedical Sciences, Università "G. D'Annunzio"/Chieti/Italie (2 aut., 3 aut.); Pharma Research Basel Neuroscience, Bau 72/150, F. Hoffmann-La Roche Ltd./4070 Basel/Suisse (1 aut.); Schering-Plough Research Institute, 2015 Galloping Hill Road/Kenilworth, NJ 07033-1300/Etats-Unis (1 aut.); Centre for Addiction and Mental Health, 250 College St. Toronto/Toronto, Ontario, M5T 1R8/Canada (2 aut.); Departments of Psychiatry and Psychology, University of Toronto/Toronto, Ontario/Canada (2 aut.) |
DT : | Publication en série; Niveau analytique |
SO : | Pharmacology, biochemistry and behavior; ISSN 0091-3057; Coden PBBHAU; Etats-Unis; Da. 2002; Vol. 71; No. 4; Pp. 727-734; Bibl. 1 p.1/4 |
LA : | Anglais |
EA : | There is substantial evidence that the functional status of mesocorticolimbic dopaminergic (DA) system originating in the ventral tegmental area (VTA) is under a phasic and tonic inhibitory control by the serotonergic system, which acts by stimulating serotonin2C (5-HT2C) receptor subtypes. This assertion is based upon a number of electrophysiological and biochemical data showing that 5-HT2C receptor agonists decrease, while 5-HT2C receptor antagonists enhance mesocorticolimbic DA function. On the other hand, it does not seem that 5-HT2C receptors play a relevant role in the control of nigrostriatal DA system originating in the substantia nigra pars compacta (SNc). The authors of this article review the most relevant data regarding the role of 5-HT2C receptors in the control of brain DA function and underline the importance of this subject in the search of new therapies for neuropsychiatric disorders such as depression, schizophrenia, drug addiction, and Parkinson's disease. |
CC : | 002B02B09C; 002A04F03B |
FD : | Récepteur sérotoninergique 5-HT2C; Rat; Homme; Etat dépressif; In vitro; In vivo; Schizophrénie; Parkinson maladie; Dépendance; Article synthèse; Sérotonine; Voie dopaminergique; Encéphale; Dopamine; Antagoniste; Agoniste; Système nerveux central; Aire tegmentaire ventrale; Locus niger; Voie nigrostriatale; Neuroleptique; Psychotrope; Animal; Voie mésolimbique; Antidépresseur |
FG : | Rodentia; Mammalia; Vertebrata; Catécholamine; Trouble humeur; Psychose; Système nerveux pathologie; Système nerveux central pathologie; Encéphale pathologie; Extrapyramidal syndrome; Maladie dégénérative |
ED : | 5-HT2C serotonin receptor; Rat; Human; Depression; In vitro; In vivo; Schizophrenia; Parkinson disease; Dependence; Review; Serotonin; Dopaminergic pathway; Brain (vertebrata); Dopamine; Antagonist; Agonist; Central nervous system; Ventral tegmental area; Locus niger; Nigrostriatal pathway; Neuroleptic; Psychotropic; Animal; Mesolimbic pathway; Antidepressant agent |
EG : | Rodentia; Mammalia; Vertebrata; Catecholamine; Mood disorder; Psychosis; Nervous system diseases; Central nervous system disease; Cerebral disorder; Extrapyramidal syndrome; Degenerative disease |
SD : | Receptor serotoninérgico 5-HT2C; Rata; Hombre; Estado depresivo; In vitro; In vivo; Esquizofrenia; Parkinson enfermedad; Dependencia; Artículo síntesis; Serotonina; Vía dopaminérgica; Encéfalo; Dopamina; Antagonista; Agonista; Sistema nervioso central; Area tegmental ventral; Locus níger; Vía nigroestriatal; Neuroléptico; Psicotropo; Animal; Vía mesolímbica; Antidepresor |
LO : | INIST-16578.354000100614230190 |
ID : | 02-0355643 |
Links to Exploration step
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<front><div type="abstract" xml:lang="en">There is substantial evidence that the functional status of mesocorticolimbic dopaminergic (DA) system originating in the ventral tegmental area (VTA) is under a phasic and tonic inhibitory control by the serotonergic system, which acts by stimulating serotonin<sub>2C</sub>
(5-HT<sub>2C</sub>
) receptor subtypes. This assertion is based upon a number of electrophysiological and biochemical data showing that 5-HT<sub>2C</sub>
receptor agonists decrease, while 5-HT<sub>2C</sub>
receptor antagonists enhance mesocorticolimbic DA function. On the other hand, it does not seem that 5-HT<sub>2C</sub>
receptors play a relevant role in the control of nigrostriatal DA system originating in the substantia nigra pars compacta (SNc). The authors of this article review the most relevant data regarding the role of 5-HT<sub>2C</sub>
receptors in the control of brain DA function and underline the importance of this subject in the search of new therapies for neuropsychiatric disorders such as depression, schizophrenia, drug addiction, and Parkinson's disease.</div>
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receptor agonists decrease, while 5-HT<sub>2C</sub>
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<s5>14</s5>
</fC03>
<fC03 i1="12" i2="X" l="SPA"><s0>Vía dopaminérgica</s0>
<s5>14</s5>
</fC03>
<fC03 i1="13" i2="X" l="FRE"><s0>Encéphale</s0>
<s5>15</s5>
</fC03>
<fC03 i1="13" i2="X" l="ENG"><s0>Brain (vertebrata)</s0>
<s5>15</s5>
</fC03>
<fC03 i1="13" i2="X" l="SPA"><s0>Encéfalo</s0>
<s5>15</s5>
</fC03>
<fC03 i1="14" i2="X" l="FRE"><s0>Dopamine</s0>
<s2>NK</s2>
<s2>FR</s2>
<s5>16</s5>
</fC03>
<fC03 i1="14" i2="X" l="ENG"><s0>Dopamine</s0>
<s2>NK</s2>
<s2>FR</s2>
<s5>16</s5>
</fC03>
<fC03 i1="14" i2="X" l="SPA"><s0>Dopamina</s0>
<s2>NK</s2>
<s2>FR</s2>
<s5>16</s5>
</fC03>
<fC03 i1="15" i2="X" l="FRE"><s0>Antagoniste</s0>
<s5>17</s5>
</fC03>
<fC03 i1="15" i2="X" l="ENG"><s0>Antagonist</s0>
<s5>17</s5>
</fC03>
<fC03 i1="15" i2="X" l="SPA"><s0>Antagonista</s0>
<s5>17</s5>
</fC03>
<fC03 i1="16" i2="X" l="FRE"><s0>Agoniste</s0>
<s5>18</s5>
</fC03>
<fC03 i1="16" i2="X" l="ENG"><s0>Agonist</s0>
<s5>18</s5>
</fC03>
<fC03 i1="16" i2="X" l="SPA"><s0>Agonista</s0>
<s5>18</s5>
</fC03>
<fC03 i1="17" i2="X" l="FRE"><s0>Système nerveux central</s0>
<s5>19</s5>
</fC03>
<fC03 i1="17" i2="X" l="ENG"><s0>Central nervous system</s0>
<s5>19</s5>
</fC03>
<fC03 i1="17" i2="X" l="SPA"><s0>Sistema nervioso central</s0>
<s5>19</s5>
</fC03>
<fC03 i1="18" i2="X" l="FRE"><s0>Aire tegmentaire ventrale</s0>
<s5>20</s5>
</fC03>
<fC03 i1="18" i2="X" l="ENG"><s0>Ventral tegmental area</s0>
<s5>20</s5>
</fC03>
<fC03 i1="18" i2="X" l="SPA"><s0>Area tegmental ventral</s0>
<s5>20</s5>
</fC03>
<fC03 i1="19" i2="X" l="FRE"><s0>Locus niger</s0>
<s5>21</s5>
</fC03>
<fC03 i1="19" i2="X" l="ENG"><s0>Locus niger</s0>
<s5>21</s5>
</fC03>
<fC03 i1="19" i2="X" l="SPA"><s0>Locus níger</s0>
<s5>21</s5>
</fC03>
<fC03 i1="20" i2="X" l="FRE"><s0>Voie nigrostriatale</s0>
<s5>22</s5>
</fC03>
<fC03 i1="20" i2="X" l="ENG"><s0>Nigrostriatal pathway</s0>
<s5>22</s5>
</fC03>
<fC03 i1="20" i2="X" l="SPA"><s0>Vía nigroestriatal</s0>
<s5>22</s5>
</fC03>
<fC03 i1="21" i2="X" l="FRE"><s0>Neuroleptique</s0>
<s5>23</s5>
</fC03>
<fC03 i1="21" i2="X" l="ENG"><s0>Neuroleptic</s0>
<s5>23</s5>
</fC03>
<fC03 i1="21" i2="X" l="SPA"><s0>Neuroléptico</s0>
<s5>23</s5>
</fC03>
<fC03 i1="22" i2="X" l="FRE"><s0>Psychotrope</s0>
<s2>FX</s2>
<s5>24</s5>
</fC03>
<fC03 i1="22" i2="X" l="ENG"><s0>Psychotropic</s0>
<s2>FX</s2>
<s5>24</s5>
</fC03>
<fC03 i1="22" i2="X" l="SPA"><s0>Psicotropo</s0>
<s2>FX</s2>
<s5>24</s5>
</fC03>
<fC03 i1="23" i2="X" l="FRE"><s0>Animal</s0>
<s5>35</s5>
</fC03>
<fC03 i1="23" i2="X" l="ENG"><s0>Animal</s0>
<s5>35</s5>
</fC03>
<fC03 i1="23" i2="X" l="SPA"><s0>Animal</s0>
<s5>35</s5>
</fC03>
<fC03 i1="24" i2="X" l="FRE"><s0>Voie mésolimbique</s0>
<s5>78</s5>
</fC03>
<fC03 i1="24" i2="X" l="ENG"><s0>Mesolimbic pathway</s0>
<s5>78</s5>
</fC03>
<fC03 i1="24" i2="X" l="SPA"><s0>Vía mesolímbica</s0>
<s5>78</s5>
</fC03>
<fC03 i1="25" i2="X" l="FRE"><s0>Antidépresseur</s0>
<s5>79</s5>
</fC03>
<fC03 i1="25" i2="X" l="ENG"><s0>Antidepressant agent</s0>
<s5>79</s5>
</fC03>
<fC03 i1="25" i2="X" l="SPA"><s0>Antidepresor</s0>
<s5>79</s5>
</fC03>
<fC07 i1="01" i2="X" l="FRE"><s0>Rodentia</s0>
<s2>NS</s2>
</fC07>
<fC07 i1="01" i2="X" l="ENG"><s0>Rodentia</s0>
<s2>NS</s2>
</fC07>
<fC07 i1="01" i2="X" l="SPA"><s0>Rodentia</s0>
<s2>NS</s2>
</fC07>
<fC07 i1="02" i2="X" l="FRE"><s0>Mammalia</s0>
<s2>NS</s2>
</fC07>
<fC07 i1="02" i2="X" l="ENG"><s0>Mammalia</s0>
<s2>NS</s2>
</fC07>
<fC07 i1="02" i2="X" l="SPA"><s0>Mammalia</s0>
<s2>NS</s2>
</fC07>
<fC07 i1="03" i2="X" l="FRE"><s0>Vertebrata</s0>
<s2>NS</s2>
</fC07>
<fC07 i1="03" i2="X" l="ENG"><s0>Vertebrata</s0>
<s2>NS</s2>
</fC07>
<fC07 i1="03" i2="X" l="SPA"><s0>Vertebrata</s0>
<s2>NS</s2>
</fC07>
<fC07 i1="04" i2="X" l="FRE"><s0>Catécholamine</s0>
<s5>37</s5>
</fC07>
<fC07 i1="04" i2="X" l="ENG"><s0>Catecholamine</s0>
<s5>37</s5>
</fC07>
<fC07 i1="04" i2="X" l="SPA"><s0>Catecolamina</s0>
<s5>37</s5>
</fC07>
<fC07 i1="05" i2="X" l="FRE"><s0>Trouble humeur</s0>
<s5>45</s5>
</fC07>
<fC07 i1="05" i2="X" l="ENG"><s0>Mood disorder</s0>
<s5>45</s5>
</fC07>
<fC07 i1="05" i2="X" l="SPA"><s0>Trastorno humor</s0>
<s5>45</s5>
</fC07>
<fC07 i1="06" i2="X" l="FRE"><s0>Psychose</s0>
<s5>53</s5>
</fC07>
<fC07 i1="06" i2="X" l="ENG"><s0>Psychosis</s0>
<s5>53</s5>
</fC07>
<fC07 i1="06" i2="X" l="SPA"><s0>Psicosis</s0>
<s5>53</s5>
</fC07>
<fC07 i1="07" i2="X" l="FRE"><s0>Système nerveux pathologie</s0>
<s5>61</s5>
</fC07>
<fC07 i1="07" i2="X" l="ENG"><s0>Nervous system diseases</s0>
<s5>61</s5>
</fC07>
<fC07 i1="07" i2="X" l="SPA"><s0>Sistema nervioso patología</s0>
<s5>61</s5>
</fC07>
<fC07 i1="08" i2="X" l="FRE"><s0>Système nerveux central pathologie</s0>
<s5>62</s5>
</fC07>
<fC07 i1="08" i2="X" l="ENG"><s0>Central nervous system disease</s0>
<s5>62</s5>
</fC07>
<fC07 i1="08" i2="X" l="SPA"><s0>Sistema nervosio central patología</s0>
<s5>62</s5>
</fC07>
<fC07 i1="09" i2="X" l="FRE"><s0>Encéphale pathologie</s0>
<s5>63</s5>
</fC07>
<fC07 i1="09" i2="X" l="ENG"><s0>Cerebral disorder</s0>
<s5>63</s5>
</fC07>
<fC07 i1="09" i2="X" l="SPA"><s0>Encéfalo patología</s0>
<s5>63</s5>
</fC07>
<fC07 i1="10" i2="X" l="FRE"><s0>Extrapyramidal syndrome</s0>
<s5>64</s5>
</fC07>
<fC07 i1="10" i2="X" l="ENG"><s0>Extrapyramidal syndrome</s0>
<s5>64</s5>
</fC07>
<fC07 i1="10" i2="X" l="SPA"><s0>Extrapiramidal síndrome</s0>
<s5>64</s5>
</fC07>
<fC07 i1="11" i2="X" l="FRE"><s0>Maladie dégénérative</s0>
<s5>65</s5>
</fC07>
<fC07 i1="11" i2="X" l="ENG"><s0>Degenerative disease</s0>
<s5>65</s5>
</fC07>
<fC07 i1="11" i2="X" l="SPA"><s0>Enfermedad degenerativa</s0>
<s5>65</s5>
</fC07>
<fN21><s1>196</s1>
</fN21>
<fN82><s1>PSI</s1>
</fN82>
</pA>
</standard>
<server><NO>PASCAL 02-0355643 INIST</NO>
<ET>Role of serotonin<sub>2C</sub>
receptors in the control of brain dopaminergic function</ET>
<AU>DI MATTEO (Vincenzo); CACCHIO (Marisa); DI GIULIO (Camillo); ESPOSITO (Ennio); HIGGINS (Guy A.); FLETCHER (Paul J.)</AU>
<AF>Istituto di Ricerche Farmacologiche "Mario Negri", Consorzio "Mario Negri" Sud/66030 Santa Maria Imbaro, Chieti/Italie (1 aut., 4 aut.); Department of Biomedical Sciences, Università "G. D'Annunzio"/Chieti/Italie (2 aut., 3 aut.); Pharma Research Basel Neuroscience, Bau 72/150, F. Hoffmann-La Roche Ltd./4070 Basel/Suisse (1 aut.); Schering-Plough Research Institute, 2015 Galloping Hill Road/Kenilworth, NJ 07033-1300/Etats-Unis (1 aut.); Centre for Addiction and Mental Health, 250 College St. Toronto/Toronto, Ontario, M5T 1R8/Canada (2 aut.); Departments of Psychiatry and Psychology, University of Toronto/Toronto, Ontario/Canada (2 aut.)</AF>
<DT>Publication en série; Niveau analytique</DT>
<SO>Pharmacology, biochemistry and behavior; ISSN 0091-3057; Coden PBBHAU; Etats-Unis; Da. 2002; Vol. 71; No. 4; Pp. 727-734; Bibl. 1 p.1/4</SO>
<LA>Anglais</LA>
<EA>There is substantial evidence that the functional status of mesocorticolimbic dopaminergic (DA) system originating in the ventral tegmental area (VTA) is under a phasic and tonic inhibitory control by the serotonergic system, which acts by stimulating serotonin<sub>2C</sub>
(5-HT<sub>2C</sub>
) receptor subtypes. This assertion is based upon a number of electrophysiological and biochemical data showing that 5-HT<sub>2C</sub>
receptor agonists decrease, while 5-HT<sub>2C</sub>
receptor antagonists enhance mesocorticolimbic DA function. On the other hand, it does not seem that 5-HT<sub>2C</sub>
receptors play a relevant role in the control of nigrostriatal DA system originating in the substantia nigra pars compacta (SNc). The authors of this article review the most relevant data regarding the role of 5-HT<sub>2C</sub>
receptors in the control of brain DA function and underline the importance of this subject in the search of new therapies for neuropsychiatric disorders such as depression, schizophrenia, drug addiction, and Parkinson's disease.</EA>
<CC>002B02B09C; 002A04F03B</CC>
<FD>Récepteur sérotoninergique 5-HT2C; Rat; Homme; Etat dépressif; In vitro; In vivo; Schizophrénie; Parkinson maladie; Dépendance; Article synthèse; Sérotonine; Voie dopaminergique; Encéphale; Dopamine; Antagoniste; Agoniste; Système nerveux central; Aire tegmentaire ventrale; Locus niger; Voie nigrostriatale; Neuroleptique; Psychotrope; Animal; Voie mésolimbique; Antidépresseur</FD>
<FG>Rodentia; Mammalia; Vertebrata; Catécholamine; Trouble humeur; Psychose; Système nerveux pathologie; Système nerveux central pathologie; Encéphale pathologie; Extrapyramidal syndrome; Maladie dégénérative</FG>
<ED>5-HT2C serotonin receptor; Rat; Human; Depression; In vitro; In vivo; Schizophrenia; Parkinson disease; Dependence; Review; Serotonin; Dopaminergic pathway; Brain (vertebrata); Dopamine; Antagonist; Agonist; Central nervous system; Ventral tegmental area; Locus niger; Nigrostriatal pathway; Neuroleptic; Psychotropic; Animal; Mesolimbic pathway; Antidepressant agent</ED>
<EG>Rodentia; Mammalia; Vertebrata; Catecholamine; Mood disorder; Psychosis; Nervous system diseases; Central nervous system disease; Cerebral disorder; Extrapyramidal syndrome; Degenerative disease</EG>
<SD>Receptor serotoninérgico 5-HT2C; Rata; Hombre; Estado depresivo; In vitro; In vivo; Esquizofrenia; Parkinson enfermedad; Dependencia; Artículo síntesis; Serotonina; Vía dopaminérgica; Encéfalo; Dopamina; Antagonista; Agonista; Sistema nervioso central; Area tegmental ventral; Locus níger; Vía nigroestriatal; Neuroléptico; Psicotropo; Animal; Vía mesolímbica; Antidepresor</SD>
<LO>INIST-16578.354000100614230190</LO>
<ID>02-0355643</ID>
</server>
</inist>
</record>
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