ParkinsonCanadaV1, PascalFrancis, Corpus, bibRecord, 000B38

Usefulness of invasive electrophysiologic testing to stratify the risk of arrhythmic events in asymptomatic patients with Wolff-Parkinson-white pattern: Results from a large prospective long-term follow-up study. Commentary

Identifieur interne : 000B38 ( PascalFrancis/Corpus ); précédent : 000B37; suivant : 000B39

Usefulness of invasive electrophysiologic testing to stratify the risk of arrhythmic events in asymptomatic patients with Wolff-Parkinson-white pattern: Results from a large prospective long-term follow-up study. Commentary

Auteurs : Carlo Pappone ; Vincenzo Santinelli ; Salvatore Rosanio ; Gabriele Vicedomini ; Stefano Nardi ; Alessia Pappone ; Valter Tortoriello ; Francesco Manguso ; Patrizio Mazzone ; Simone Gulletta ; Giuseppe Oreto ; Ottavio Alfieri ; Derick M. Todd ; George J. Klein ; Andrew D. Krahn ; Allan C. Skanes ; Raymond Yee

Source :

Journal of the American College of Cardiology [ 0735-1097 ] ; 2003.

RBID : Pascal:03-0109954

Descripteurs français

Pascal (Inist)
- Wolff Parkinson White syndrome, Homme, Analyse risque, Electrophysiologie, Exploration, Technique, Asymptomatique, Trouble rythme cardiaque, Complication, Pronostic, Morbidité.

English descriptors

KwdEn :
- Arrhythmia, Asymptomatic, Complication, Electrophysiology, Exploration, Human, Morbidity, Prognosis, Risk analysis, Technique, Wolff Parkinson White syndrome.

Abstract

OBJECTIVES The aim of this study was to assess in a large cohort of asymptomatic subjects with Wolff-Parkinson-White (WPW) pattern the usefulness of invasive electrophysiologic testing (EPT) in predicting the occurrence of arrhythmic events over a five-year follow-up. BACKGROUND Sudden death may be the first clinical manifestation of the WPW syndrome in previously asymptomatic patients. Serial EPTs have been proposed to identify patients at risk. METHODS A total of 212 consecutive asymptomatic WPW patients were enrolled after a baseline EPT; patients were followed for five years, and 162 patients (115 noninducible and 47 inducible) patients underwent a second EPT. RESULTS After a mean follow-up of 37.7 months, 33 patients became symptomatic. Of the 115 noninducible patients, 18.2% lost anterograde accessory pathway (AP) conduction, 30% retrograde AP conduction, and only 4 (3.4%) developed symptomatic supraventricular tachycardia (SVT). Of the 47 inducible patients, 25 with sustained atrioventricular reciprocating tachycardia (AVRT) and atrial fibrillation (AF), and 4 with nonsustained AVRT and AF became symptomatic for SVT (n = 21) and AF (n = 8). They were younger, had shorter AP anterograde refractory periods, and multiple APs compared to patients who remained asymptomatic (for all comparisons, p < 0.0001). Of the eight patients with symptomatic episodes of AF and inducible sustained AF, two had a resuscitated cardiac arrest and one died suddenly; all three patients were inducible for AVRT and AF and had multiple APs. CONCLUSIONS In asymptomatic WPW subjects, EPT may be a valuable tool to stratify the risk of symptomatic and fatal arrhythmic events.

Notice en format standard (ISO 2709)

Pour connaître la documentation sur le format Inist Standard.

A01	`01`	`1`		`@0 0735-1097`
A02	`01`			`@0 JACCDI`
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A05				`@2 41`
A06				`@2 2`
A08	`01`	`1`	`ENG`	`@1 Usefulness of invasive electrophysiologic testing to stratify the risk of arrhythmic events in asymptomatic patients with Wolff-Parkinson-white pattern: Results from a large prospective long-term follow-up study. Commentary`
A11	`01`	`1`		`@1 PAPPONE (Carlo)`
A11	`02`	`1`		`@1 SANTINELLI (Vincenzo)`
A11	`03`	`1`		`@1 ROSANIO (Salvatore)`
A11	`04`	`1`		`@1 VICEDOMINI (Gabriele)`
A11	`05`	`1`		`@1 NARDI (Stefano)`
A11	`06`	`1`		`@1 PAPPONE (Alessia)`
A11	`07`	`1`		`@1 TORTORIELLO (Valter)`
A11	`08`	`1`		`@1 MANGUSO (Francesco)`
A11	`09`	`1`		`@1 MAZZONE (Patrizio)`
A11	`10`	`1`		`@1 GULLETTA (Simone)`
A11	`11`	`1`		`@1 ORETO (Giuseppe)`
A11	`12`	`1`		`@1 ALFIERI (Ottavio)`
A11	`13`	`1`		`@1 TODD (Derick M.) @9 comment.`
A11	`14`	`1`		`@1 KLEIN (George J.) @9 comment.`
A11	`15`	`1`		`@1 KRAHN (Andrew D.) @9 comment.`
A11	`16`	`1`		`@1 SKANES (Allan C.) @9 comment.`
A11	`17`	`1`		`@1 YEE (Raymond) @9 comment.`
A14	`01`			`@1 Department of Cardiology, Electrophysiology, and Cardiac Pacing Unit, San Raffaele University Hospital @2 Milan @3 ITA @Z 1 aut. @Z 2 aut. @Z 3 aut. @Z 4 aut. @Z 5 aut. @Z 6 aut. @Z 7 aut. @Z 8 aut. @Z 9 aut. @Z 10 aut. @Z 11 aut.`
A14	`02`			`@1 University of Western Ontario @2 London, Ontario @3 CAN @Z 12 aut. @Z 13 aut. @Z 14 aut. @Z 15 aut. @Z 16 aut. @Z 17 aut.`
A20				`@1 239-248`
A21				`@1 2003`
A23	`01`			`@0 ENG`
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A44				`@0 0000 @1 © 2003 INIST-CNRS. All rights reserved.`
A45				`@0 42 ref.`
A47	`01`	`1`		`@0 03-0109954`
A60				`@1 P @3 AR @3 CT`
A61				`@0 A`
A64	`01`	`1`		`@0 Journal of the American College of Cardiology`
A66	`01`			`@0 USA`
C01	`01`		`ENG`	@0 OBJECTIVES The aim of this study was to assess in a large cohort of asymptomatic subjects with Wolff-Parkinson-White (WPW) pattern the usefulness of invasive electrophysiologic testing (EPT) in predicting the occurrence of arrhythmic events over a five-year follow-up. BACKGROUND Sudden death may be the first clinical manifestation of the WPW syndrome in previously asymptomatic patients. Serial EPTs have been proposed to identify patients at risk. METHODS A total of 212 consecutive asymptomatic WPW patients were enrolled after a baseline EPT; patients were followed for five years, and 162 patients (115 noninducible and 47 inducible) patients underwent a second EPT. RESULTS After a mean follow-up of 37.7 months, 33 patients became symptomatic. Of the 115 noninducible patients, 18.2% lost anterograde accessory pathway (AP) conduction, 30% retrograde AP conduction, and only 4 (3.4%) developed symptomatic supraventricular tachycardia (SVT). Of the 47 inducible patients, 25 with sustained atrioventricular reciprocating tachycardia (AVRT) and atrial fibrillation (AF), and 4 with nonsustained AVRT and AF became symptomatic for SVT (n = 21) and AF (n = 8). They were younger, had shorter AP anterograde refractory periods, and multiple APs compared to patients who remained asymptomatic (for all comparisons, p < 0.0001). Of the eight patients with symptomatic episodes of AF and inducible sustained AF, two had a resuscitated cardiac arrest and one died suddenly; all three patients were inducible for AVRT and AF and had multiple APs. CONCLUSIONS In asymptomatic WPW subjects, EPT may be a valuable tool to stratify the risk of symptomatic and fatal arrhythmic events.
C02	`01`	`X`		`@0 002B24D01`
C03	`01`	`X`	`FRE`	`@0 Wolff Parkinson White syndrome @5 01`
C03	`01`	`X`	`ENG`	`@0 Wolff Parkinson White syndrome @5 01`
C03	`01`	`X`	`SPA`	`@0 Wolff Parkinson White síndrome @5 01`
C03	`02`	`X`	`FRE`	`@0 Homme @5 02`
C03	`02`	`X`	`ENG`	`@0 Human @5 02`
C03	`02`	`X`	`SPA`	`@0 Hombre @5 02`
C03	`03`	`X`	`FRE`	`@0 Analyse risque @5 03`
C03	`03`	`X`	`ENG`	`@0 Risk analysis @5 03`
C03	`03`	`X`	`SPA`	`@0 Análisis riesgo @5 03`
C03	`04`	`X`	`FRE`	`@0 Electrophysiologie @5 04`
C03	`04`	`X`	`ENG`	`@0 Electrophysiology @5 04`
C03	`04`	`X`	`SPA`	`@0 Electrofisiología @5 04`
C03	`05`	`X`	`FRE`	`@0 Exploration @5 05`
C03	`05`	`X`	`ENG`	`@0 Exploration @5 05`
C03	`05`	`X`	`SPA`	`@0 Exploración @5 05`
C03	`06`	`X`	`FRE`	`@0 Technique @5 06`
C03	`06`	`X`	`ENG`	`@0 Technique @5 06`
C03	`06`	`X`	`SPA`	`@0 Técnica @5 06`
C03	`07`	`X`	`FRE`	`@0 Asymptomatique @5 07`
C03	`07`	`X`	`ENG`	`@0 Asymptomatic @5 07`
C03	`07`	`X`	`SPA`	`@0 Asintomático @5 07`
C03	`08`	`X`	`FRE`	`@0 Trouble rythme cardiaque @5 08`
C03	`08`	`X`	`ENG`	`@0 Arrhythmia @5 08`
C03	`08`	`X`	`SPA`	`@0 Arritmia @5 08`
C03	`09`	`X`	`FRE`	`@0 Complication @5 09`
C03	`09`	`X`	`ENG`	`@0 Complication @5 09`
C03	`09`	`X`	`SPA`	`@0 Complicación @5 09`
C03	`10`	`X`	`FRE`	`@0 Pronostic @5 10`
C03	`10`	`X`	`ENG`	`@0 Prognosis @5 10`
C03	`10`	`X`	`SPA`	`@0 Pronóstico @5 10`
C03	`11`	`X`	`FRE`	`@0 Morbidité @5 11`
C03	`11`	`X`	`ENG`	`@0 Morbidity @5 11`
C03	`11`	`X`	`SPA`	`@0 Morbilidad @5 11`
C07	`01`	`X`	`FRE`	`@0 Appareil circulatoire pathologie @5 37`
C07	`01`	`X`	`ENG`	`@0 Cardiovascular disease @5 37`
C07	`01`	`X`	`SPA`	`@0 Aparato circulatorio patología @5 37`
C07	`02`	`X`	`FRE`	`@0 Cardiopathie @5 38`
C07	`02`	`X`	`ENG`	`@0 Heart disease @5 38`
C07	`02`	`X`	`SPA`	`@0 Cardiopatía @5 38`
C07	`03`	`X`	`FRE`	`@0 Trouble excitabilité @5 40`
C07	`03`	`X`	`ENG`	`@0 Excitability disorder @5 40`
C07	`03`	`X`	`SPA`	`@0 Trastorno excitabilidad @5 40`
C07	`04`	`X`	`FRE`	`@0 Trouble conduction @5 41`
C07	`04`	`X`	`ENG`	`@0 Conduction disorder @5 41`
C07	`04`	`X`	`SPA`	`@0 Trastorno conducción @5 41`
C07	`05`	`X`	`FRE`	`@0 Préexcitation ventriculaire syndrome @5 42`
C07	`05`	`X`	`ENG`	`@0 Preexcitation ventricular syndrome @5 42`
C07	`05`	`X`	`SPA`	`@0 Preexcitación ventricular síndrome @5 42`
N21				`@1 062`
N82				`@1 PSI`

Format Inist (serveur)

NO :	PASCAL 03-0109954 INIST
ET :	Usefulness of invasive electrophysiologic testing to stratify the risk of arrhythmic events in asymptomatic patients with Wolff-Parkinson-white pattern: Results from a large prospective long-term follow-up study. Commentary
AU :	PAPPONE (Carlo); SANTINELLI (Vincenzo); ROSANIO (Salvatore); VICEDOMINI (Gabriele); NARDI (Stefano); PAPPONE (Alessia); TORTORIELLO (Valter); MANGUSO (Francesco); MAZZONE (Patrizio); GULLETTA (Simone); ORETO (Giuseppe); ALFIERI (Ottavio); TODD (Derick M.); KLEIN (George J.); KRAHN (Andrew D.); SKANES (Allan C.); YEE (Raymond)
AF :	Department of Cardiology, Electrophysiology, and Cardiac Pacing Unit, San Raffaele University Hospital/Milan/Italie (1 aut., 2 aut., 3 aut., 4 aut., 5 aut., 6 aut., 7 aut., 8 aut., 9 aut., 10 aut., 11 aut.); University of Western Ontario/London, Ontario/Canada (12 aut., 13 aut., 14 aut., 15 aut., 16 aut., 17 aut.)
DT :	Publication en série; Article; Commentaire; Niveau analytique
SO :	Journal of the American College of Cardiology; ISSN 0735-1097; Coden JACCDI; Etats-Unis; Da. 2003; Vol. 41; No. 2; Pp. 239-248; Bibl. 42 ref.
LA :	Anglais
EA :	OBJECTIVES The aim of this study was to assess in a large cohort of asymptomatic subjects with Wolff-Parkinson-White (WPW) pattern the usefulness of invasive electrophysiologic testing (EPT) in predicting the occurrence of arrhythmic events over a five-year follow-up. BACKGROUND Sudden death may be the first clinical manifestation of the WPW syndrome in previously asymptomatic patients. Serial EPTs have been proposed to identify patients at risk. METHODS A total of 212 consecutive asymptomatic WPW patients were enrolled after a baseline EPT; patients were followed for five years, and 162 patients (115 noninducible and 47 inducible) patients underwent a second EPT. RESULTS After a mean follow-up of 37.7 months, 33 patients became symptomatic. Of the 115 noninducible patients, 18.2% lost anterograde accessory pathway (AP) conduction, 30% retrograde AP conduction, and only 4 (3.4%) developed symptomatic supraventricular tachycardia (SVT). Of the 47 inducible patients, 25 with sustained atrioventricular reciprocating tachycardia (AVRT) and atrial fibrillation (AF), and 4 with nonsustained AVRT and AF became symptomatic for SVT (n = 21) and AF (n = 8). They were younger, had shorter AP anterograde refractory periods, and multiple APs compared to patients who remained asymptomatic (for all comparisons, p < 0.0001). Of the eight patients with symptomatic episodes of AF and inducible sustained AF, two had a resuscitated cardiac arrest and one died suddenly; all three patients were inducible for AVRT and AF and had multiple APs. CONCLUSIONS In asymptomatic WPW subjects, EPT may be a valuable tool to stratify the risk of symptomatic and fatal arrhythmic events.
CC :	002B24D01
FD :	Wolff Parkinson White syndrome; Homme; Analyse risque; Electrophysiologie; Exploration; Technique; Asymptomatique; Trouble rythme cardiaque; Complication; Pronostic; Morbidité
FG :	Appareil circulatoire pathologie; Cardiopathie; Trouble excitabilité; Trouble conduction; Préexcitation ventriculaire syndrome
ED :	Wolff Parkinson White syndrome; Human; Risk analysis; Electrophysiology; Exploration; Technique; Asymptomatic; Arrhythmia; Complication; Prognosis; Morbidity
EG :	Cardiovascular disease; Heart disease; Excitability disorder; Conduction disorder; Preexcitation ventricular syndrome
SD :	Wolff Parkinson White síndrome; Hombre; Análisis riesgo; Electrofisiología; Exploración; Técnica; Asintomático; Arritmia; Complicación; Pronóstico; Morbilidad
LO :	INIST-20098.354000103689350100
ID :	03-0109954

Links to Exploration step

Pascal:03-0109954

Le document en format XML

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<author><name sortKey="Gulletta, Simone" sort="Gulletta, Simone" uniqKey="Gulletta S" first="Simone" last="Gulletta">Simone Gulletta</name>
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<author><name sortKey="Oreto, Giuseppe" sort="Oreto, Giuseppe" uniqKey="Oreto G" first="Giuseppe" last="Oreto">Giuseppe Oreto</name>
<affiliation><inist:fA14 i1="01"><s1>Department of Cardiology, Electrophysiology, and Cardiac Pacing Unit, San Raffaele University Hospital</s1>
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<author><name sortKey="Todd, Derick M" sort="Todd, Derick M" uniqKey="Todd D" first="Derick M." last="Todd">Derick M. Todd</name>
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<s2>London, Ontario</s2>
<s3>CAN</s3>
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<affiliation><inist:fA14 i1="02"><s1>University of Western Ontario</s1>
<s2>London, Ontario</s2>
<s3>CAN</s3>
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<publicationStmt><idno type="wicri:source">INIST</idno>
<idno type="inist">03-0109954</idno>
<date when="2003">2003</date>
<idno type="stanalyst">PASCAL 03-0109954 INIST</idno>
<idno type="RBID">Pascal:03-0109954</idno>
<idno type="wicri:Area/PascalFrancis/Corpus">000B38</idno>
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<sourceDesc><biblStruct><analytic><title xml:lang="en" level="a">Usefulness of invasive electrophysiologic testing to stratify the risk of arrhythmic events in asymptomatic patients with Wolff-Parkinson-white pattern: Results from a large prospective long-term follow-up study. Commentary</title>
<author><name sortKey="Pappone, Carlo" sort="Pappone, Carlo" uniqKey="Pappone C" first="Carlo" last="Pappone">Carlo Pappone</name>
<affiliation><inist:fA14 i1="01"><s1>Department of Cardiology, Electrophysiology, and Cardiac Pacing Unit, San Raffaele University Hospital</s1>
<s2>Milan</s2>
<s3>ITA</s3>
<sZ>1 aut.</sZ>
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</author>
<author><name sortKey="Santinelli, Vincenzo" sort="Santinelli, Vincenzo" uniqKey="Santinelli V" first="Vincenzo" last="Santinelli">Vincenzo Santinelli</name>
<affiliation><inist:fA14 i1="01"><s1>Department of Cardiology, Electrophysiology, and Cardiac Pacing Unit, San Raffaele University Hospital</s1>
<s2>Milan</s2>
<s3>ITA</s3>
<sZ>1 aut.</sZ>
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</affiliation>
</author>
<author><name sortKey="Rosanio, Salvatore" sort="Rosanio, Salvatore" uniqKey="Rosanio S" first="Salvatore" last="Rosanio">Salvatore Rosanio</name>
<affiliation><inist:fA14 i1="01"><s1>Department of Cardiology, Electrophysiology, and Cardiac Pacing Unit, San Raffaele University Hospital</s1>
<s2>Milan</s2>
<s3>ITA</s3>
<sZ>1 aut.</sZ>
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</author>
<author><name sortKey="Vicedomini, Gabriele" sort="Vicedomini, Gabriele" uniqKey="Vicedomini G" first="Gabriele" last="Vicedomini">Gabriele Vicedomini</name>
<affiliation><inist:fA14 i1="01"><s1>Department of Cardiology, Electrophysiology, and Cardiac Pacing Unit, San Raffaele University Hospital</s1>
<s2>Milan</s2>
<s3>ITA</s3>
<sZ>1 aut.</sZ>
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<author><name sortKey="Nardi, Stefano" sort="Nardi, Stefano" uniqKey="Nardi S" first="Stefano" last="Nardi">Stefano Nardi</name>
<affiliation><inist:fA14 i1="01"><s1>Department of Cardiology, Electrophysiology, and Cardiac Pacing Unit, San Raffaele University Hospital</s1>
<s2>Milan</s2>
<s3>ITA</s3>
<sZ>1 aut.</sZ>
<sZ>2 aut.</sZ>
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<author><name sortKey="Pappone, Alessia" sort="Pappone, Alessia" uniqKey="Pappone A" first="Alessia" last="Pappone">Alessia Pappone</name>
<affiliation><inist:fA14 i1="01"><s1>Department of Cardiology, Electrophysiology, and Cardiac Pacing Unit, San Raffaele University Hospital</s1>
<s2>Milan</s2>
<s3>ITA</s3>
<sZ>1 aut.</sZ>
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</author>
<author><name sortKey="Tortoriello, Valter" sort="Tortoriello, Valter" uniqKey="Tortoriello V" first="Valter" last="Tortoriello">Valter Tortoriello</name>
<affiliation><inist:fA14 i1="01"><s1>Department of Cardiology, Electrophysiology, and Cardiac Pacing Unit, San Raffaele University Hospital</s1>
<s2>Milan</s2>
<s3>ITA</s3>
<sZ>1 aut.</sZ>
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<author><name sortKey="Manguso, Francesco" sort="Manguso, Francesco" uniqKey="Manguso F" first="Francesco" last="Manguso">Francesco Manguso</name>
<affiliation><inist:fA14 i1="01"><s1>Department of Cardiology, Electrophysiology, and Cardiac Pacing Unit, San Raffaele University Hospital</s1>
<s2>Milan</s2>
<s3>ITA</s3>
<sZ>1 aut.</sZ>
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<author><name sortKey="Mazzone, Patrizio" sort="Mazzone, Patrizio" uniqKey="Mazzone P" first="Patrizio" last="Mazzone">Patrizio Mazzone</name>
<affiliation><inist:fA14 i1="01"><s1>Department of Cardiology, Electrophysiology, and Cardiac Pacing Unit, San Raffaele University Hospital</s1>
<s2>Milan</s2>
<s3>ITA</s3>
<sZ>1 aut.</sZ>
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</author>
<author><name sortKey="Gulletta, Simone" sort="Gulletta, Simone" uniqKey="Gulletta S" first="Simone" last="Gulletta">Simone Gulletta</name>
<affiliation><inist:fA14 i1="01"><s1>Department of Cardiology, Electrophysiology, and Cardiac Pacing Unit, San Raffaele University Hospital</s1>
<s2>Milan</s2>
<s3>ITA</s3>
<sZ>1 aut.</sZ>
<sZ>2 aut.</sZ>
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</author>
<author><name sortKey="Oreto, Giuseppe" sort="Oreto, Giuseppe" uniqKey="Oreto G" first="Giuseppe" last="Oreto">Giuseppe Oreto</name>
<affiliation><inist:fA14 i1="01"><s1>Department of Cardiology, Electrophysiology, and Cardiac Pacing Unit, San Raffaele University Hospital</s1>
<s2>Milan</s2>
<s3>ITA</s3>
<sZ>1 aut.</sZ>
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</author>
<author><name sortKey="Alfieri, Ottavio" sort="Alfieri, Ottavio" uniqKey="Alfieri O" first="Ottavio" last="Alfieri">Ottavio Alfieri</name>
<affiliation><inist:fA14 i1="02"><s1>University of Western Ontario</s1>
<s2>London, Ontario</s2>
<s3>CAN</s3>
<sZ>12 aut.</sZ>
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</author>
<author><name sortKey="Todd, Derick M" sort="Todd, Derick M" uniqKey="Todd D" first="Derick M." last="Todd">Derick M. Todd</name>
<affiliation><inist:fA14 i1="02"><s1>University of Western Ontario</s1>
<s2>London, Ontario</s2>
<s3>CAN</s3>
<sZ>12 aut.</sZ>
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<author><name sortKey="Klein, George J" sort="Klein, George J" uniqKey="Klein G" first="George J." last="Klein">George J. Klein</name>
<affiliation><inist:fA14 i1="02"><s1>University of Western Ontario</s1>
<s2>London, Ontario</s2>
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<author><name sortKey="Krahn, Andrew D" sort="Krahn, Andrew D" uniqKey="Krahn A" first="Andrew D." last="Krahn">Andrew D. Krahn</name>
<affiliation><inist:fA14 i1="02"><s1>University of Western Ontario</s1>
<s2>London, Ontario</s2>
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<author><name sortKey="Skanes, Allan C" sort="Skanes, Allan C" uniqKey="Skanes A" first="Allan C." last="Skanes">Allan C. Skanes</name>
<affiliation><inist:fA14 i1="02"><s1>University of Western Ontario</s1>
<s2>London, Ontario</s2>
<s3>CAN</s3>
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</author>
<author><name sortKey="Yee, Raymond" sort="Yee, Raymond" uniqKey="Yee R" first="Raymond" last="Yee">Raymond Yee</name>
<affiliation><inist:fA14 i1="02"><s1>University of Western Ontario</s1>
<s2>London, Ontario</s2>
<s3>CAN</s3>
<sZ>12 aut.</sZ>
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</analytic>
<series><title level="j" type="main">Journal of the American College of Cardiology</title>
<title level="j" type="abbreviated">J. Am. Coll. Cardiol.</title>
<idno type="ISSN">0735-1097</idno>
<imprint><date when="2003">2003</date>
</imprint>
</series>
</biblStruct>
</sourceDesc>
<seriesStmt><title level="j" type="main">Journal of the American College of Cardiology</title>
<title level="j" type="abbreviated">J. Am. Coll. Cardiol.</title>
<idno type="ISSN">0735-1097</idno>
</seriesStmt>
</fileDesc>
<profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Arrhythmia</term>
<term>Asymptomatic</term>
<term>Complication</term>
<term>Electrophysiology</term>
<term>Exploration</term>
<term>Human</term>
<term>Morbidity</term>
<term>Prognosis</term>
<term>Risk analysis</term>
<term>Technique</term>
<term>Wolff Parkinson White syndrome</term>
</keywords>
<keywords scheme="Pascal" xml:lang="fr"><term>Wolff Parkinson White syndrome</term>
<term>Homme</term>
<term>Analyse risque</term>
<term>Electrophysiologie</term>
<term>Exploration</term>
<term>Technique</term>
<term>Asymptomatique</term>
<term>Trouble rythme cardiaque</term>
<term>Complication</term>
<term>Pronostic</term>
<term>Morbidité</term>
</keywords>
</textClass>
</profileDesc>
</teiHeader>
<front><div type="abstract" xml:lang="en">OBJECTIVES The aim of this study was to assess in a large cohort of asymptomatic subjects with Wolff-Parkinson-White (WPW) pattern the usefulness of invasive electrophysiologic testing (EPT) in predicting the occurrence of arrhythmic events over a five-year follow-up. BACKGROUND Sudden death may be the first clinical manifestation of the WPW syndrome in previously asymptomatic patients. Serial EPTs have been proposed to identify patients at risk. METHODS A total of 212 consecutive asymptomatic WPW patients were enrolled after a baseline EPT; patients were followed for five years, and 162 patients (115 noninducible and 47 inducible) patients underwent a second EPT. RESULTS After a mean follow-up of 37.7 months, 33 patients became symptomatic. Of the 115 noninducible patients, 18.2% lost anterograde accessory pathway (AP) conduction, 30% retrograde AP conduction, and only 4 (3.4%) developed symptomatic supraventricular tachycardia (SVT). Of the 47 inducible patients, 25 with sustained atrioventricular reciprocating tachycardia (AVRT) and atrial fibrillation (AF), and 4 with nonsustained AVRT and AF became symptomatic for SVT (n = 21) and AF (n = 8). They were younger, had shorter AP anterograde refractory periods, and multiple APs compared to patients who remained asymptomatic (for all comparisons, p < 0.0001). Of the eight patients with symptomatic episodes of AF and inducible sustained AF, two had a resuscitated cardiac arrest and one died suddenly; all three patients were inducible for AVRT and AF and had multiple APs. CONCLUSIONS In asymptomatic WPW subjects, EPT may be a valuable tool to stratify the risk of symptomatic and fatal arrhythmic events.</div>
</front>
</TEI>
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</fA01>
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</fA02>
<fA03 i2="1"><s0>J. Am. Coll. Cardiol.</s0>
</fA03>
<fA05><s2>41</s2>
</fA05>
<fA06><s2>2</s2>
</fA06>
<fA08 i1="01" i2="1" l="ENG"><s1>Usefulness of invasive electrophysiologic testing to stratify the risk of arrhythmic events in asymptomatic patients with Wolff-Parkinson-white pattern: Results from a large prospective long-term follow-up study. Commentary</s1>
</fA08>
<fA11 i1="01" i2="1"><s1>PAPPONE (Carlo)</s1>
</fA11>
<fA11 i1="02" i2="1"><s1>SANTINELLI (Vincenzo)</s1>
</fA11>
<fA11 i1="03" i2="1"><s1>ROSANIO (Salvatore)</s1>
</fA11>
<fA11 i1="04" i2="1"><s1>VICEDOMINI (Gabriele)</s1>
</fA11>
<fA11 i1="05" i2="1"><s1>NARDI (Stefano)</s1>
</fA11>
<fA11 i1="06" i2="1"><s1>PAPPONE (Alessia)</s1>
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<fA11 i1="07" i2="1"><s1>TORTORIELLO (Valter)</s1>
</fA11>
<fA11 i1="08" i2="1"><s1>MANGUSO (Francesco)</s1>
</fA11>
<fA11 i1="09" i2="1"><s1>MAZZONE (Patrizio)</s1>
</fA11>
<fA11 i1="10" i2="1"><s1>GULLETTA (Simone)</s1>
</fA11>
<fA11 i1="11" i2="1"><s1>ORETO (Giuseppe)</s1>
</fA11>
<fA11 i1="12" i2="1"><s1>ALFIERI (Ottavio)</s1>
</fA11>
<fA11 i1="13" i2="1"><s1>TODD (Derick M.)</s1>
<s9>comment.</s9>
</fA11>
<fA11 i1="14" i2="1"><s1>KLEIN (George J.)</s1>
<s9>comment.</s9>
</fA11>
<fA11 i1="15" i2="1"><s1>KRAHN (Andrew D.)</s1>
<s9>comment.</s9>
</fA11>
<fA11 i1="16" i2="1"><s1>SKANES (Allan C.)</s1>
<s9>comment.</s9>
</fA11>
<fA11 i1="17" i2="1"><s1>YEE (Raymond)</s1>
<s9>comment.</s9>
</fA11>
<fA14 i1="01"><s1>Department of Cardiology, Electrophysiology, and Cardiac Pacing Unit, San Raffaele University Hospital</s1>
<s2>Milan</s2>
<s3>ITA</s3>
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</fA14>
<fA14 i1="02"><s1>University of Western Ontario</s1>
<s2>London, Ontario</s2>
<s3>CAN</s3>
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<fA20><s1>239-248</s1>
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<fA21><s1>2003</s1>
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<s5>354000103689350100</s5>
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<s1>© 2003 INIST-CNRS. All rights reserved.</s1>
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<fA64 i1="01" i2="1"><s0>Journal of the American College of Cardiology</s0>
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<fA66 i1="01"><s0>USA</s0>
</fA66>
<fC01 i1="01" l="ENG"><s0>OBJECTIVES The aim of this study was to assess in a large cohort of asymptomatic subjects with Wolff-Parkinson-White (WPW) pattern the usefulness of invasive electrophysiologic testing (EPT) in predicting the occurrence of arrhythmic events over a five-year follow-up. BACKGROUND Sudden death may be the first clinical manifestation of the WPW syndrome in previously asymptomatic patients. Serial EPTs have been proposed to identify patients at risk. METHODS A total of 212 consecutive asymptomatic WPW patients were enrolled after a baseline EPT; patients were followed for five years, and 162 patients (115 noninducible and 47 inducible) patients underwent a second EPT. RESULTS After a mean follow-up of 37.7 months, 33 patients became symptomatic. Of the 115 noninducible patients, 18.2% lost anterograde accessory pathway (AP) conduction, 30% retrograde AP conduction, and only 4 (3.4%) developed symptomatic supraventricular tachycardia (SVT). Of the 47 inducible patients, 25 with sustained atrioventricular reciprocating tachycardia (AVRT) and atrial fibrillation (AF), and 4 with nonsustained AVRT and AF became symptomatic for SVT (n = 21) and AF (n = 8). They were younger, had shorter AP anterograde refractory periods, and multiple APs compared to patients who remained asymptomatic (for all comparisons, p < 0.0001). Of the eight patients with symptomatic episodes of AF and inducible sustained AF, two had a resuscitated cardiac arrest and one died suddenly; all three patients were inducible for AVRT and AF and had multiple APs. CONCLUSIONS In asymptomatic WPW subjects, EPT may be a valuable tool to stratify the risk of symptomatic and fatal arrhythmic events.</s0>
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<fC03 i1="01" i2="X" l="FRE"><s0>Wolff Parkinson White syndrome</s0>
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<fC03 i1="01" i2="X" l="ENG"><s0>Wolff Parkinson White syndrome</s0>
<s5>01</s5>
</fC03>
<fC03 i1="01" i2="X" l="SPA"><s0>Wolff Parkinson White síndrome</s0>
<s5>01</s5>
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<s5>02</s5>
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<s5>02</s5>
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<s5>02</s5>
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<s5>03</s5>
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<s5>06</s5>
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<s5>06</s5>
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<s5>06</s5>
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<s5>07</s5>
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<s5>07</s5>
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<s5>07</s5>
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<fC03 i1="08" i2="X" l="FRE"><s0>Trouble rythme cardiaque</s0>
<s5>08</s5>
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<fC03 i1="08" i2="X" l="ENG"><s0>Arrhythmia</s0>
<s5>08</s5>
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<fC03 i1="08" i2="X" l="SPA"><s0>Arritmia</s0>
<s5>08</s5>
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<fC03 i1="09" i2="X" l="FRE"><s0>Complication</s0>
<s5>09</s5>
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<s5>09</s5>
</fC03>
<fC03 i1="09" i2="X" l="SPA"><s0>Complicación</s0>
<s5>09</s5>
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<fC03 i1="10" i2="X" l="FRE"><s0>Pronostic</s0>
<s5>10</s5>
</fC03>
<fC03 i1="10" i2="X" l="ENG"><s0>Prognosis</s0>
<s5>10</s5>
</fC03>
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<s5>10</s5>
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<s5>11</s5>
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<s5>38</s5>
</fC07>
<fC07 i1="02" i2="X" l="SPA"><s0>Cardiopatía</s0>
<s5>38</s5>
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<fC07 i1="03" i2="X" l="FRE"><s0>Trouble excitabilité</s0>
<s5>40</s5>
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<fC07 i1="03" i2="X" l="ENG"><s0>Excitability disorder</s0>
<s5>40</s5>
</fC07>
<fC07 i1="03" i2="X" l="SPA"><s0>Trastorno excitabilidad</s0>
<s5>40</s5>
</fC07>
<fC07 i1="04" i2="X" l="FRE"><s0>Trouble conduction</s0>
<s5>41</s5>
</fC07>
<fC07 i1="04" i2="X" l="ENG"><s0>Conduction disorder</s0>
<s5>41</s5>
</fC07>
<fC07 i1="04" i2="X" l="SPA"><s0>Trastorno conducción</s0>
<s5>41</s5>
</fC07>
<fC07 i1="05" i2="X" l="FRE"><s0>Préexcitation ventriculaire syndrome</s0>
<s5>42</s5>
</fC07>
<fC07 i1="05" i2="X" l="ENG"><s0>Preexcitation ventricular syndrome</s0>
<s5>42</s5>
</fC07>
<fC07 i1="05" i2="X" l="SPA"><s0>Preexcitación ventricular síndrome</s0>
<s5>42</s5>
</fC07>
<fN21><s1>062</s1>
</fN21>
<fN82><s1>PSI</s1>
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<server><NO>PASCAL 03-0109954 INIST</NO>
<ET>Usefulness of invasive electrophysiologic testing to stratify the risk of arrhythmic events in asymptomatic patients with Wolff-Parkinson-white pattern: Results from a large prospective long-term follow-up study. Commentary</ET>
<AU>PAPPONE (Carlo); SANTINELLI (Vincenzo); ROSANIO (Salvatore); VICEDOMINI (Gabriele); NARDI (Stefano); PAPPONE (Alessia); TORTORIELLO (Valter); MANGUSO (Francesco); MAZZONE (Patrizio); GULLETTA (Simone); ORETO (Giuseppe); ALFIERI (Ottavio); TODD (Derick M.); KLEIN (George J.); KRAHN (Andrew D.); SKANES (Allan C.); YEE (Raymond)</AU>
<AF>Department of Cardiology, Electrophysiology, and Cardiac Pacing Unit, San Raffaele University Hospital/Milan/Italie (1 aut., 2 aut., 3 aut., 4 aut., 5 aut., 6 aut., 7 aut., 8 aut., 9 aut., 10 aut., 11 aut.); University of Western Ontario/London, Ontario/Canada (12 aut., 13 aut., 14 aut., 15 aut., 16 aut., 17 aut.)</AF>
<DT>Publication en série; Article; Commentaire; Niveau analytique</DT>
<SO>Journal of the American College of Cardiology; ISSN 0735-1097; Coden JACCDI; Etats-Unis; Da. 2003; Vol. 41; No. 2; Pp. 239-248; Bibl. 42 ref.</SO>
<LA>Anglais</LA>
<EA>OBJECTIVES The aim of this study was to assess in a large cohort of asymptomatic subjects with Wolff-Parkinson-White (WPW) pattern the usefulness of invasive electrophysiologic testing (EPT) in predicting the occurrence of arrhythmic events over a five-year follow-up. BACKGROUND Sudden death may be the first clinical manifestation of the WPW syndrome in previously asymptomatic patients. Serial EPTs have been proposed to identify patients at risk. METHODS A total of 212 consecutive asymptomatic WPW patients were enrolled after a baseline EPT; patients were followed for five years, and 162 patients (115 noninducible and 47 inducible) patients underwent a second EPT. RESULTS After a mean follow-up of 37.7 months, 33 patients became symptomatic. Of the 115 noninducible patients, 18.2% lost anterograde accessory pathway (AP) conduction, 30% retrograde AP conduction, and only 4 (3.4%) developed symptomatic supraventricular tachycardia (SVT). Of the 47 inducible patients, 25 with sustained atrioventricular reciprocating tachycardia (AVRT) and atrial fibrillation (AF), and 4 with nonsustained AVRT and AF became symptomatic for SVT (n = 21) and AF (n = 8). They were younger, had shorter AP anterograde refractory periods, and multiple APs compared to patients who remained asymptomatic (for all comparisons, p < 0.0001). Of the eight patients with symptomatic episodes of AF and inducible sustained AF, two had a resuscitated cardiac arrest and one died suddenly; all three patients were inducible for AVRT and AF and had multiple APs. CONCLUSIONS In asymptomatic WPW subjects, EPT may be a valuable tool to stratify the risk of symptomatic and fatal arrhythmic events.</EA>
<CC>002B24D01</CC>
<FD>Wolff Parkinson White syndrome; Homme; Analyse risque; Electrophysiologie; Exploration; Technique; Asymptomatique; Trouble rythme cardiaque; Complication; Pronostic; Morbidité</FD>
<FG>Appareil circulatoire pathologie; Cardiopathie; Trouble excitabilité; Trouble conduction; Préexcitation ventriculaire syndrome</FG>
<ED>Wolff Parkinson White syndrome; Human; Risk analysis; Electrophysiology; Exploration; Technique; Asymptomatic; Arrhythmia; Complication; Prognosis; Morbidity</ED>
<EG>Cardiovascular disease; Heart disease; Excitability disorder; Conduction disorder; Preexcitation ventricular syndrome</EG>
<SD>Wolff Parkinson White síndrome; Hombre; Análisis riesgo; Electrofisiología; Exploración; Técnica; Asintomático; Arritmia; Complicación; Pronóstico; Morbilidad</SD>
<LO>INIST-20098.354000103689350100</LO>
<ID>03-0109954</ID>
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	La maladie de Parkinson au Canada (serveur d'exploration)
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La maladie de Parkinson au Canada (serveur d'exploration)

Usefulness of invasive electrophysiologic testing to stratify the risk of arrhythmic events in asymptomatic patients with Wolff-Parkinson-white pattern: Results from a large prospective long-term follow-up study. Commentary

Usefulness of invasive electrophysiologic testing to stratify the risk of arrhythmic events in asymptomatic patients with Wolff-Parkinson-white pattern: Results from a large prospective long-term follow-up study. Commentary

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