ParkinsonCanadaV1, PascalFrancis, Corpus, bibRecord, 000B33

Cortico-motor excitability of the lower limb motor representation: a comparative study in Parkinson's disease and healthy controls

Identifieur interne : 000B33 ( PascalFrancis/Corpus ); précédent : 000B32; suivant : 000B34

Cortico-motor excitability of the lower limb motor representation: a comparative study in Parkinson's disease and healthy controls

Auteurs : Francois Tremblay ; Louis E. Tremblay

Source :

Clinical neurophysiology [ 1388-2457 ] ; 2002.

RBID : Pascal:03-0199768

Descripteurs français

Pascal (Inist)
- Parkinson maladie, Excitabilité, Cortex moteur, Membre inférieur, Stimulus magnétique, Voie transcrânienne, Potentiel évoqué moteur, Muscle quadriceps, Exploration, Physiopathologie, Adulte.

English descriptors

KwdEn :
- Adult, Excitability, Exploration, Lower limb, Magnetic stimulus, Motor cortex, Motor evoked potential, Parkinson disease, Pathophysiology, Quadriceps muscle, Transcranial route.

Abstract

Objective: To compare indices of cortico-motor excitability derived from transcranial magnetic stimulation (TMS) of the lower limb motor representation in patients with Parkinson's diseases (PD) and healthy controls. Methods: The cortico-motor excitability of the lower limb motor area was studied both at rest (motor threshold, amplitude of motor evoked potentials (MEPs)) and during active contraction of the quadriceps (Quad) muscle (MEPs facilitation and silent period) in 10 PD patients (11 legs) and 11 healthy controls using single pulse TMS. Results: At rest, the motor threshold was found to be significantly lower and the amplitude of MEPs larger in patients than in controls. During active knee contraction, patients produced lower levels of MEP facilitation with respect to baseline values and the silent period was lengthened in comparison to controls. Conclusions: The present results provide further evidence from the lower limb motor area that enhanced cortico-spinal excitability is an important feature in the pathophysiology of PD.

Notice en format standard (ISO 2709)

Pour connaître la documentation sur le format Inist Standard.

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A08	`01`	`1`	`ENG`	`@1 Cortico-motor excitability of the lower limb motor representation: a comparative study in Parkinson's disease and healthy controls`
A11	`01`	`1`		`@1 TREMBLAY (Francois)`
A11	`02`	`1`		`@1 TREMBLAY (Louis E.)`
A14	`01`			`@1 Physiotherapy Program, School of Rehabilitation Sciences, Faculty of Health Sciences, University of Ottawa @2 Ottawa, Ontario, K1H 8M5 @3 CAN @Z 1 aut. @Z 2 aut.`
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A47	`01`	`1`		`@0 03-0199768`
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A61				`@0 A`
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C01	`01`		`ENG`	@0 Objective: To compare indices of cortico-motor excitability derived from transcranial magnetic stimulation (TMS) of the lower limb motor representation in patients with Parkinson's diseases (PD) and healthy controls. Methods: The cortico-motor excitability of the lower limb motor area was studied both at rest (motor threshold, amplitude of motor evoked potentials (MEPs)) and during active contraction of the quadriceps (Quad) muscle (MEPs facilitation and silent period) in 10 PD patients (11 legs) and 11 healthy controls using single pulse TMS. Results: At rest, the motor threshold was found to be significantly lower and the amplitude of MEPs larger in patients than in controls. During active knee contraction, patients produced lower levels of MEP facilitation with respect to baseline values and the silent period was lengthened in comparison to controls. Conclusions: The present results provide further evidence from the lower limb motor area that enhanced cortico-spinal excitability is an important feature in the pathophysiology of PD.
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C03	`01`	`X`	`SPA`	`@0 Parkinson enfermedad @5 01`
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C03	`04`	`X`	`SPA`	`@0 Miembro inferior @5 08`
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C03	`06`	`X`	`FRE`	`@0 Voie transcrânienne @5 11`
C03	`06`	`X`	`ENG`	`@0 Transcranial route @5 11`
C03	`06`	`X`	`SPA`	`@0 Vía transcraneana @5 11`
C03	`07`	`X`	`FRE`	`@0 Potentiel évoqué moteur @5 12`
C03	`07`	`X`	`ENG`	`@0 Motor evoked potential @5 12`
C03	`07`	`X`	`SPA`	`@0 Potencial evocado motor @5 12`
C03	`08`	`X`	`FRE`	`@0 Muscle quadriceps @5 13`
C03	`08`	`X`	`ENG`	`@0 Quadriceps muscle @5 13`
C03	`08`	`X`	`SPA`	`@0 Músculo cuadriceps @5 13`
C03	`09`	`X`	`FRE`	`@0 Exploration @5 17`
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C03	`10`	`X`	`SPA`	`@0 Fisiopatología @5 18`
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C07	`06`	`X`	`FRE`	`@0 Maladie dégénérative @5 41`
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C07	`06`	`X`	`SPA`	`@0 Enfermedad degenerativa @5 41`
C07	`07`	`X`	`FRE`	`@0 Electrodiagnostic @5 61`
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N21				`@1 118`
N82				`@1 PSI`

Format Inist (serveur)

NO :	PASCAL 03-0199768 INIST
ET :	Cortico-motor excitability of the lower limb motor representation: a comparative study in Parkinson's disease and healthy controls
AU :	TREMBLAY (Francois); TREMBLAY (Louis E.)
AF :	Physiotherapy Program, School of Rehabilitation Sciences, Faculty of Health Sciences, University of Ottawa/Ottawa, Ontario, K1H 8M5/Canada (1 aut., 2 aut.)
DT :	Publication en série; Niveau analytique
SO :	Clinical neurophysiology; ISSN 1388-2457; Irlande; Da. 2002; Vol. 113; No. 12; Pp. 2006-2012; Bibl. 18 ref.
LA :	Anglais
EA :	Objective: To compare indices of cortico-motor excitability derived from transcranial magnetic stimulation (TMS) of the lower limb motor representation in patients with Parkinson's diseases (PD) and healthy controls. Methods: The cortico-motor excitability of the lower limb motor area was studied both at rest (motor threshold, amplitude of motor evoked potentials (MEPs)) and during active contraction of the quadriceps (Quad) muscle (MEPs facilitation and silent period) in 10 PD patients (11 legs) and 11 healthy controls using single pulse TMS. Results: At rest, the motor threshold was found to be significantly lower and the amplitude of MEPs larger in patients than in controls. During active knee contraction, patients produced lower levels of MEP facilitation with respect to baseline values and the silent period was lengthened in comparison to controls. Conclusions: The present results provide further evidence from the lower limb motor area that enhanced cortico-spinal excitability is an important feature in the pathophysiology of PD.
CC :	002B17G
FD :	Parkinson maladie; Excitabilité; Cortex moteur; Membre inférieur; Stimulus magnétique; Voie transcrânienne; Potentiel évoqué moteur; Muscle quadriceps; Exploration; Physiopathologie; Adulte
FG :	Homme; Système nerveux pathologie; Système nerveux central pathologie; Encéphale pathologie; Extrapyramidal syndrome; Maladie dégénérative; Electrodiagnostic
ED :	Parkinson disease; Excitability; Motor cortex; Lower limb; Magnetic stimulus; Transcranial route; Motor evoked potential; Quadriceps muscle; Exploration; Pathophysiology; Adult
EG :	Human; Nervous system diseases; Central nervous system disease; Cerebral disorder; Extrapyramidal syndrome; Degenerative disease; Electrodiagnosis
SD :	Parkinson enfermedad; Excitabilidad; Corteza motora; Miembro inferior; Estímulo magnético; Vía transcraneana; Potencial evocado motor; Músculo cuadriceps; Exploración; Fisiopatología; Adulto
LO :	INIST-5626E.354000106970510180
ID :	03-0199768

Links to Exploration step

Pascal:03-0199768

Le document en format XML

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<front><div type="abstract" xml:lang="en">Objective: To compare indices of cortico-motor excitability derived from transcranial magnetic stimulation (TMS) of the lower limb motor representation in patients with Parkinson's diseases (PD) and healthy controls. Methods: The cortico-motor excitability of the lower limb motor area was studied both at rest (motor threshold, amplitude of motor evoked potentials (MEPs)) and during active contraction of the quadriceps (Quad) muscle (MEPs facilitation and silent period) in 10 PD patients (11 legs) and 11 healthy controls using single pulse TMS. Results: At rest, the motor threshold was found to be significantly lower and the amplitude of MEPs larger in patients than in controls. During active knee contraction, patients produced lower levels of MEP facilitation with respect to baseline values and the silent period was lengthened in comparison to controls. Conclusions: The present results provide further evidence from the lower limb motor area that enhanced cortico-spinal excitability is an important feature in the pathophysiology of PD.</div>
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<fC01 i1="01" l="ENG"><s0>Objective: To compare indices of cortico-motor excitability derived from transcranial magnetic stimulation (TMS) of the lower limb motor representation in patients with Parkinson's diseases (PD) and healthy controls. Methods: The cortico-motor excitability of the lower limb motor area was studied both at rest (motor threshold, amplitude of motor evoked potentials (MEPs)) and during active contraction of the quadriceps (Quad) muscle (MEPs facilitation and silent period) in 10 PD patients (11 legs) and 11 healthy controls using single pulse TMS. Results: At rest, the motor threshold was found to be significantly lower and the amplitude of MEPs larger in patients than in controls. During active knee contraction, patients produced lower levels of MEP facilitation with respect to baseline values and the silent period was lengthened in comparison to controls. Conclusions: The present results provide further evidence from the lower limb motor area that enhanced cortico-spinal excitability is an important feature in the pathophysiology of PD.</s0>
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<server><NO>PASCAL 03-0199768 INIST</NO>
<ET>Cortico-motor excitability of the lower limb motor representation: a comparative study in Parkinson's disease and healthy controls</ET>
<AU>TREMBLAY (Francois); TREMBLAY (Louis E.)</AU>
<AF>Physiotherapy Program, School of Rehabilitation Sciences, Faculty of Health Sciences, University of Ottawa/Ottawa, Ontario, K1H 8M5/Canada (1 aut., 2 aut.)</AF>
<DT>Publication en série; Niveau analytique</DT>
<SO>Clinical neurophysiology; ISSN 1388-2457; Irlande; Da. 2002; Vol. 113; No. 12; Pp. 2006-2012; Bibl. 18 ref.</SO>
<LA>Anglais</LA>
<EA>Objective: To compare indices of cortico-motor excitability derived from transcranial magnetic stimulation (TMS) of the lower limb motor representation in patients with Parkinson's diseases (PD) and healthy controls. Methods: The cortico-motor excitability of the lower limb motor area was studied both at rest (motor threshold, amplitude of motor evoked potentials (MEPs)) and during active contraction of the quadriceps (Quad) muscle (MEPs facilitation and silent period) in 10 PD patients (11 legs) and 11 healthy controls using single pulse TMS. Results: At rest, the motor threshold was found to be significantly lower and the amplitude of MEPs larger in patients than in controls. During active knee contraction, patients produced lower levels of MEP facilitation with respect to baseline values and the silent period was lengthened in comparison to controls. Conclusions: The present results provide further evidence from the lower limb motor area that enhanced cortico-spinal excitability is an important feature in the pathophysiology of PD.</EA>
<CC>002B17G</CC>
<FD>Parkinson maladie; Excitabilité; Cortex moteur; Membre inférieur; Stimulus magnétique; Voie transcrânienne; Potentiel évoqué moteur; Muscle quadriceps; Exploration; Physiopathologie; Adulte</FD>
<FG>Homme; Système nerveux pathologie; Système nerveux central pathologie; Encéphale pathologie; Extrapyramidal syndrome; Maladie dégénérative; Electrodiagnostic</FG>
<ED>Parkinson disease; Excitability; Motor cortex; Lower limb; Magnetic stimulus; Transcranial route; Motor evoked potential; Quadriceps muscle; Exploration; Pathophysiology; Adult</ED>
<EG>Human; Nervous system diseases; Central nervous system disease; Cerebral disorder; Extrapyramidal syndrome; Degenerative disease; Electrodiagnosis</EG>
<SD>Parkinson enfermedad; Excitabilidad; Corteza motora; Miembro inferior; Estímulo magnético; Vía transcraneana; Potencial evocado motor; Músculo cuadriceps; Exploración; Fisiopatología; Adulto</SD>
<LO>INIST-5626E.354000106970510180</LO>
<ID>03-0199768</ID>
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	La maladie de Parkinson au Canada (serveur d'exploration)
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La maladie de Parkinson au Canada (serveur d'exploration)

Cortico-motor excitability of the lower limb motor representation: a comparative study in Parkinson's disease and healthy controls

Cortico-motor excitability of the lower limb motor representation: a comparative study in Parkinson's disease and healthy controls

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