ParkinsonCanadaV1, PascalFrancis, Corpus, bibRecord, 000897

Identification of motor and nonmotor wearing-off in Parkinson's disease : Comparison of a patient questionnaire versus a clinician assessment

Identifieur interne : 000897 ( PascalFrancis/Corpus ); précédent : 000896; suivant : 000898

Identification of motor and nonmotor wearing-off in Parkinson's disease : Comparison of a patient questionnaire versus a clinician assessment

Auteurs : Mark Stacy ; Annette Bowron ; Mark Guttman ; Robert Hauser ; Kim Hughes ; Jan Petter Larsen ; Peter Lewitt ; Wolfgang Oertel ; Niall Quinn ; Kapil Sethi ; Fabrizio Stocchi

Source :

Movement disorders [ 0885-3185 ] ; 2005.

RBID : Pascal:05-0363945

Descripteurs français

Pascal (Inist)
- Système nerveux pathologie, Parkinson maladie, Etude comparative, Homme, Questionnaire, Fluctuation.

English descriptors

KwdEn :
- Comparative study, Fluctuations, Human, Nervous system diseases, Parkinson disease, Questionnaire.

Abstract

This study compares the sensitivity of a Patient Questionnaire versus information gathered by clinicians at a routine clinic visit in recognizing symptoms of wearing-off in early Parkinson's disease (PD). This Patient Questionnaire, containing 32 items representing a wide spectrum of motor and nonmotor wearing-off symptoms, was administered to subjects attending two PD clinics. The Patient Questionnaire results were compared to the information gathered by the clinician from the Unified Parkinson's Disease Rating Scale (UPDRS) Part IV, Question 36 and from a specific Clinical Assessment Question regarding loss of medication efficacy, wearing-off, sleepiness, dyskinesias, psychiatric complications, morning akinesia, other dopaminergic side effects, or none of the above. Examiners were blinded to study hypothesis and survey contents. Three hundred consecutive subjects with PD of <5 years duration were evaluated; the mean subject age was 72 ± 9.6 years and 60.2% were men. Subjects reporting wearing-off were significantly younger (69.9 vs. 74.7 years) and differed regarding duration of PD symptoms (3.7 vs. 3.1 years). Wearing-off was found in 181 subjects (62.6%) by one or more of the three measures. The most sensitive tool was the Patient Questionnaire, with 165 subjects (57.1%) indicating symptoms of wearing-off. Question 36 of the UPDRS was positive in 127 subjects (43.9%), and the Clinical Assessment Question identified 85 subjects (29.4%) as experiencing wearing-off. All of these results were found to differ significantly. The mean number of wearing-off symptoms reported by the 165 subjects indicating wearing-off on the clinical survey was 6.25, with tremor being the most common motor feature and tiredness the most common nonmotor feature.

Notice en format standard (ISO 2709)

Pour connaître la documentation sur le format Inist Standard.

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A11	`07`	`1`		`@1 LEWITT (Peter)`
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A14	`05`			`@1 The Planning Shop International @2 London @3 GBR @Z 5 aut.`
A14	`06`			`@1 Central Hospital of Rogaland @2 Slavanger @3 NOR @Z 6 aut.`
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C01	`01`		`ENG`	@0 This study compares the sensitivity of a Patient Questionnaire versus information gathered by clinicians at a routine clinic visit in recognizing symptoms of wearing-off in early Parkinson's disease (PD). This Patient Questionnaire, containing 32 items representing a wide spectrum of motor and nonmotor wearing-off symptoms, was administered to subjects attending two PD clinics. The Patient Questionnaire results were compared to the information gathered by the clinician from the Unified Parkinson's Disease Rating Scale (UPDRS) Part IV, Question 36 and from a specific Clinical Assessment Question regarding loss of medication efficacy, wearing-off, sleepiness, dyskinesias, psychiatric complications, morning akinesia, other dopaminergic side effects, or none of the above. Examiners were blinded to study hypothesis and survey contents. Three hundred consecutive subjects with PD of <5 years duration were evaluated; the mean subject age was 72 ± 9.6 years and 60.2% were men. Subjects reporting wearing-off were significantly younger (69.9 vs. 74.7 years) and differed regarding duration of PD symptoms (3.7 vs. 3.1 years). Wearing-off was found in 181 subjects (62.6%) by one or more of the three measures. The most sensitive tool was the Patient Questionnaire, with 165 subjects (57.1%) indicating symptoms of wearing-off. Question 36 of the UPDRS was positive in 127 subjects (43.9%), and the Clinical Assessment Question identified 85 subjects (29.4%) as experiencing wearing-off. All of these results were found to differ significantly. The mean number of wearing-off symptoms reported by the 165 subjects indicating wearing-off on the clinical survey was 6.25, with tremor being the most common motor feature and tiredness the most common nonmotor feature.
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Format Inist (serveur)

NO :	PASCAL 05-0363945 INIST
ET :	Identification of motor and nonmotor wearing-off in Parkinson's disease : Comparison of a patient questionnaire versus a clinician assessment
AU :	STACY (Mark); BOWRON (Annette); GUTTMAN (Mark); HAUSER (Robert); HUGHES (Kim); LARSEN (Jan Petter); LEWITT (Peter); OERTEL (Wolfgang); QUINN (Niall); SETHI (Kapil); STOCCHI (Fabrizio)
AF :	Duke University Medical Center/Durham, North Carolina/Etats-Unis (1 aut.); North Tyneside General Hospital/North Shields/Royaume-Uni (2 aut.); University of Toronto, Division of Neurology/Toronto/Canada (3 aut.); University of South Florida College of Medicine/Tampa, Florida/Etats-Unis (4 aut.); The Planning Shop International/London/Royaume-Uni (5 aut.); Central Hospital of Rogaland/Slavanger/Norvège (6 aut.); Wayne State University School of Medicine/Detroit, Michigan/Etats-Unis (7 aut.); Center of Nervous Diseases, Philipps-University/Marburg/Allemagne (8 aut.); Institute of Neurology/London/Royaume-Uni (9 aut.); Medical College of Georgia/Augusta, Georgia/Etats-Unis (10 aut.); Institute of Neurology, IRCCS NEUROMED/Pozzilli/Italie (11 aut.)
DT :	Publication en série; Niveau analytique
SO :	Movement disorders; ISSN 0885-3185; Etats-Unis; Da. 2005; Vol. 20; No. 6; Pp. 726-733; Bibl. 17 ref.
LA :	Anglais
EA :	This study compares the sensitivity of a Patient Questionnaire versus information gathered by clinicians at a routine clinic visit in recognizing symptoms of wearing-off in early Parkinson's disease (PD). This Patient Questionnaire, containing 32 items representing a wide spectrum of motor and nonmotor wearing-off symptoms, was administered to subjects attending two PD clinics. The Patient Questionnaire results were compared to the information gathered by the clinician from the Unified Parkinson's Disease Rating Scale (UPDRS) Part IV, Question 36 and from a specific Clinical Assessment Question regarding loss of medication efficacy, wearing-off, sleepiness, dyskinesias, psychiatric complications, morning akinesia, other dopaminergic side effects, or none of the above. Examiners were blinded to study hypothesis and survey contents. Three hundred consecutive subjects with PD of <5 years duration were evaluated; the mean subject age was 72 ± 9.6 years and 60.2% were men. Subjects reporting wearing-off were significantly younger (69.9 vs. 74.7 years) and differed regarding duration of PD symptoms (3.7 vs. 3.1 years). Wearing-off was found in 181 subjects (62.6%) by one or more of the three measures. The most sensitive tool was the Patient Questionnaire, with 165 subjects (57.1%) indicating symptoms of wearing-off. Question 36 of the UPDRS was positive in 127 subjects (43.9%), and the Clinical Assessment Question identified 85 subjects (29.4%) as experiencing wearing-off. All of these results were found to differ significantly. The mean number of wearing-off symptoms reported by the 165 subjects indicating wearing-off on the clinical survey was 6.25, with tremor being the most common motor feature and tiredness the most common nonmotor feature.
CC :	002B17; 002B17G; 002B17F
FD :	Système nerveux pathologie; Parkinson maladie; Etude comparative; Homme; Questionnaire; Fluctuation
FG :	Encéphale pathologie; Extrapyramidal syndrome; Maladie dégénérative; Système nerveux central pathologie
ED :	Nervous system diseases; Parkinson disease; Comparative study; Human; Questionnaire; Fluctuations
EG :	Cerebral disorder; Extrapyramidal syndrome; Degenerative disease; Central nervous system disease
SD :	Sistema nervioso patología; Parkinson enfermedad; Estudio comparativo; Hombre; Cuestionario; Fluctuación
LO :	INIST-20953.354000138604660100
ID :	05-0363945

Links to Exploration step

Pascal:05-0363945

Le document en format XML

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<author><name sortKey="Stocchi, Fabrizio" sort="Stocchi, Fabrizio" uniqKey="Stocchi F" first="Fabrizio" last="Stocchi">Fabrizio Stocchi</name>
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<sourceDesc><biblStruct><analytic><title xml:lang="en" level="a">Identification of motor and nonmotor wearing-off in Parkinson's disease : Comparison of a patient questionnaire versus a clinician assessment</title>
<author><name sortKey="Stacy, Mark" sort="Stacy, Mark" uniqKey="Stacy M" first="Mark" last="Stacy">Mark Stacy</name>
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<author><name sortKey="Oertel, Wolfgang" sort="Oertel, Wolfgang" uniqKey="Oertel W" first="Wolfgang" last="Oertel">Wolfgang Oertel</name>
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<author><name sortKey="Quinn, Niall" sort="Quinn, Niall" uniqKey="Quinn N" first="Niall" last="Quinn">Niall Quinn</name>
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<author><name sortKey="Sethi, Kapil" sort="Sethi, Kapil" uniqKey="Sethi K" first="Kapil" last="Sethi">Kapil Sethi</name>
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<author><name sortKey="Stocchi, Fabrizio" sort="Stocchi, Fabrizio" uniqKey="Stocchi F" first="Fabrizio" last="Stocchi">Fabrizio Stocchi</name>
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<series><title level="j" type="main">Movement disorders</title>
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<front><div type="abstract" xml:lang="en">This study compares the sensitivity of a Patient Questionnaire versus information gathered by clinicians at a routine clinic visit in recognizing symptoms of wearing-off in early Parkinson's disease (PD). This Patient Questionnaire, containing 32 items representing a wide spectrum of motor and nonmotor wearing-off symptoms, was administered to subjects attending two PD clinics. The Patient Questionnaire results were compared to the information gathered by the clinician from the Unified Parkinson's Disease Rating Scale (UPDRS) Part IV, Question 36 and from a specific Clinical Assessment Question regarding loss of medication efficacy, wearing-off, sleepiness, dyskinesias, psychiatric complications, morning akinesia, other dopaminergic side effects, or none of the above. Examiners were blinded to study hypothesis and survey contents. Three hundred consecutive subjects with PD of <5 years duration were evaluated; the mean subject age was 72 ± 9.6 years and 60.2% were men. Subjects reporting wearing-off were significantly younger (69.9 vs. 74.7 years) and differed regarding duration of PD symptoms (3.7 vs. 3.1 years). Wearing-off was found in 181 subjects (62.6%) by one or more of the three measures. The most sensitive tool was the Patient Questionnaire, with 165 subjects (57.1%) indicating symptoms of wearing-off. Question 36 of the UPDRS was positive in 127 subjects (43.9%), and the Clinical Assessment Question identified 85 subjects (29.4%) as experiencing wearing-off. All of these results were found to differ significantly. The mean number of wearing-off symptoms reported by the 165 subjects indicating wearing-off on the clinical survey was 6.25, with tremor being the most common motor feature and tiredness the most common nonmotor feature.</div>
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<fA08 i1="01" i2="1" l="ENG"><s1>Identification of motor and nonmotor wearing-off in Parkinson's disease : Comparison of a patient questionnaire versus a clinician assessment</s1>
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<fA11 i1="01" i2="1"><s1>STACY (Mark)</s1>
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<fA11 i1="02" i2="1"><s1>BOWRON (Annette)</s1>
</fA11>
<fA11 i1="03" i2="1"><s1>GUTTMAN (Mark)</s1>
</fA11>
<fA11 i1="04" i2="1"><s1>HAUSER (Robert)</s1>
</fA11>
<fA11 i1="05" i2="1"><s1>HUGHES (Kim)</s1>
</fA11>
<fA11 i1="06" i2="1"><s1>LARSEN (Jan Petter)</s1>
</fA11>
<fA11 i1="07" i2="1"><s1>LEWITT (Peter)</s1>
</fA11>
<fA11 i1="08" i2="1"><s1>OERTEL (Wolfgang)</s1>
</fA11>
<fA11 i1="09" i2="1"><s1>QUINN (Niall)</s1>
</fA11>
<fA11 i1="10" i2="1"><s1>SETHI (Kapil)</s1>
</fA11>
<fA11 i1="11" i2="1"><s1>STOCCHI (Fabrizio)</s1>
</fA11>
<fA14 i1="01"><s1>Duke University Medical Center</s1>
<s2>Durham, North Carolina</s2>
<s3>USA</s3>
<sZ>1 aut.</sZ>
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<fA14 i1="02"><s1>North Tyneside General Hospital</s1>
<s2>North Shields</s2>
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<sZ>2 aut.</sZ>
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<fA14 i1="03"><s1>University of Toronto, Division of Neurology</s1>
<s2>Toronto</s2>
<s3>CAN</s3>
<sZ>3 aut.</sZ>
</fA14>
<fA14 i1="04"><s1>University of South Florida College of Medicine</s1>
<s2>Tampa, Florida</s2>
<s3>USA</s3>
<sZ>4 aut.</sZ>
</fA14>
<fA14 i1="05"><s1>The Planning Shop International</s1>
<s2>London</s2>
<s3>GBR</s3>
<sZ>5 aut.</sZ>
</fA14>
<fA14 i1="06"><s1>Central Hospital of Rogaland</s1>
<s2>Slavanger</s2>
<s3>NOR</s3>
<sZ>6 aut.</sZ>
</fA14>
<fA14 i1="07"><s1>Wayne State University School of Medicine</s1>
<s2>Detroit, Michigan</s2>
<s3>USA</s3>
<sZ>7 aut.</sZ>
</fA14>
<fA14 i1="08"><s1>Center of Nervous Diseases, Philipps-University</s1>
<s2>Marburg</s2>
<s3>DEU</s3>
<sZ>8 aut.</sZ>
</fA14>
<fA14 i1="09"><s1>Institute of Neurology</s1>
<s2>London</s2>
<s3>GBR</s3>
<sZ>9 aut.</sZ>
</fA14>
<fA14 i1="10"><s1>Medical College of Georgia</s1>
<s2>Augusta, Georgia</s2>
<s3>USA</s3>
<sZ>10 aut.</sZ>
</fA14>
<fA14 i1="11"><s1>Institute of Neurology, IRCCS NEUROMED</s1>
<s2>Pozzilli</s2>
<s3>ITA</s3>
<sZ>11 aut.</sZ>
</fA14>
<fA20><s1>726-733</s1>
</fA20>
<fA21><s1>2005</s1>
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<fC01 i1="01" l="ENG"><s0>This study compares the sensitivity of a Patient Questionnaire versus information gathered by clinicians at a routine clinic visit in recognizing symptoms of wearing-off in early Parkinson's disease (PD). This Patient Questionnaire, containing 32 items representing a wide spectrum of motor and nonmotor wearing-off symptoms, was administered to subjects attending two PD clinics. The Patient Questionnaire results were compared to the information gathered by the clinician from the Unified Parkinson's Disease Rating Scale (UPDRS) Part IV, Question 36 and from a specific Clinical Assessment Question regarding loss of medication efficacy, wearing-off, sleepiness, dyskinesias, psychiatric complications, morning akinesia, other dopaminergic side effects, or none of the above. Examiners were blinded to study hypothesis and survey contents. Three hundred consecutive subjects with PD of <5 years duration were evaluated; the mean subject age was 72 ± 9.6 years and 60.2% were men. Subjects reporting wearing-off were significantly younger (69.9 vs. 74.7 years) and differed regarding duration of PD symptoms (3.7 vs. 3.1 years). Wearing-off was found in 181 subjects (62.6%) by one or more of the three measures. The most sensitive tool was the Patient Questionnaire, with 165 subjects (57.1%) indicating symptoms of wearing-off. Question 36 of the UPDRS was positive in 127 subjects (43.9%), and the Clinical Assessment Question identified 85 subjects (29.4%) as experiencing wearing-off. All of these results were found to differ significantly. The mean number of wearing-off symptoms reported by the 165 subjects indicating wearing-off on the clinical survey was 6.25, with tremor being the most common motor feature and tiredness the most common nonmotor feature.</s0>
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<s5>38</s5>
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<s5>38</s5>
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<s5>38</s5>
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<s5>39</s5>
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<s5>39</s5>
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<s5>39</s5>
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<ET>Identification of motor and nonmotor wearing-off in Parkinson's disease : Comparison of a patient questionnaire versus a clinician assessment</ET>
<AU>STACY (Mark); BOWRON (Annette); GUTTMAN (Mark); HAUSER (Robert); HUGHES (Kim); LARSEN (Jan Petter); LEWITT (Peter); OERTEL (Wolfgang); QUINN (Niall); SETHI (Kapil); STOCCHI (Fabrizio)</AU>
<AF>Duke University Medical Center/Durham, North Carolina/Etats-Unis (1 aut.); North Tyneside General Hospital/North Shields/Royaume-Uni (2 aut.); University of Toronto, Division of Neurology/Toronto/Canada (3 aut.); University of South Florida College of Medicine/Tampa, Florida/Etats-Unis (4 aut.); The Planning Shop International/London/Royaume-Uni (5 aut.); Central Hospital of Rogaland/Slavanger/Norvège (6 aut.); Wayne State University School of Medicine/Detroit, Michigan/Etats-Unis (7 aut.); Center of Nervous Diseases, Philipps-University/Marburg/Allemagne (8 aut.); Institute of Neurology/London/Royaume-Uni (9 aut.); Medical College of Georgia/Augusta, Georgia/Etats-Unis (10 aut.); Institute of Neurology, IRCCS NEUROMED/Pozzilli/Italie (11 aut.)</AF>
<DT>Publication en série; Niveau analytique</DT>
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<EA>This study compares the sensitivity of a Patient Questionnaire versus information gathered by clinicians at a routine clinic visit in recognizing symptoms of wearing-off in early Parkinson's disease (PD). This Patient Questionnaire, containing 32 items representing a wide spectrum of motor and nonmotor wearing-off symptoms, was administered to subjects attending two PD clinics. The Patient Questionnaire results were compared to the information gathered by the clinician from the Unified Parkinson's Disease Rating Scale (UPDRS) Part IV, Question 36 and from a specific Clinical Assessment Question regarding loss of medication efficacy, wearing-off, sleepiness, dyskinesias, psychiatric complications, morning akinesia, other dopaminergic side effects, or none of the above. Examiners were blinded to study hypothesis and survey contents. Three hundred consecutive subjects with PD of <5 years duration were evaluated; the mean subject age was 72 ± 9.6 years and 60.2% were men. Subjects reporting wearing-off were significantly younger (69.9 vs. 74.7 years) and differed regarding duration of PD symptoms (3.7 vs. 3.1 years). Wearing-off was found in 181 subjects (62.6%) by one or more of the three measures. The most sensitive tool was the Patient Questionnaire, with 165 subjects (57.1%) indicating symptoms of wearing-off. Question 36 of the UPDRS was positive in 127 subjects (43.9%), and the Clinical Assessment Question identified 85 subjects (29.4%) as experiencing wearing-off. All of these results were found to differ significantly. The mean number of wearing-off symptoms reported by the 165 subjects indicating wearing-off on the clinical survey was 6.25, with tremor being the most common motor feature and tiredness the most common nonmotor feature.</EA>
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	La maladie de Parkinson au Canada (serveur d'exploration)
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La maladie de Parkinson au Canada (serveur d'exploration)

Identification of motor and nonmotor wearing-off in Parkinson's disease : Comparison of a patient questionnaire versus a clinician assessment

Identification of motor and nonmotor wearing-off in Parkinson's disease : Comparison of a patient questionnaire versus a clinician assessment

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